Bech-Otschir D, Kapelari B, Dubiel W: The COP9 signalosome: Its Possible Role in the Ubiquitin System. Wiley-VCH Verlag GmbH & Co KGaA: Weinheim. 2005
Google Scholar
Uhle S, Medalia O, Waldron R, Dumdey R, Henklein P, Bech-Otschir D, Huang X, Berse M, Sperling J, Schade R, Dubiel W: Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. Embo J. 2003, 22: 1302-1312. 10.1093/emboj/cdg127.
Article
CAS
PubMed
PubMed Central
Google Scholar
Marklund U, Lightfoot K, Cantrell D: Intracellular location and cell context-dependent function of protein kinase D. Immunity. 2003, 19: 491-501. 10.1016/S1074-7613(03)00260-7.
Article
CAS
PubMed
Google Scholar
Rykx A, De Kimpe L, Mikhalap S, Vantus T, Seufferlein T, Vandenheede JR, Van Lint J: Protein kinase D: a family affair. FEBS Lett. 2003, 546: 81-86. 10.1016/S0014-5793(03)00487-3.
Article
CAS
PubMed
Google Scholar
Bech-Otschir D, Seeger M, Dubiel W: The COP9 signalosome: at the interface between signal transduction and ubiquitin-dependent proteolysis. J Cell Sci. 2002, 115: 467-473.
CAS
PubMed
Google Scholar
Bech-Otschir D, Kraft R, Huang X, Henklein P, Kapelari B, Pollmann C, Dubiel W: COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. Embo J. 2001, 20: 1630-1639. 10.1093/emboj/20.7.1630.
Article
CAS
PubMed
PubMed Central
Google Scholar
Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W: A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. Faseb J. 1998, 12: 469-478.
CAS
PubMed
Google Scholar
Naumann M, Bech-Otschir D, Huang X, Ferrell K, Dubiel W: COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK. J Biol Chem. 1999, 274: 35297-35300. 10.1074/jbc.274.50.35297.
Article
CAS
PubMed
Google Scholar
Slee EA, O'Connor DJ, Lu X: To die or not to die: how does p53 decide?. Oncogene. 2004, 23: 2809-2818. 10.1038/sj.onc.1207516.
Article
CAS
PubMed
Google Scholar
Vogelstein B, Lane D, Levine AJ: Surfing the p53 network. Nature. 2000, 408: 307-310. 10.1038/35042675.
Article
CAS
PubMed
Google Scholar
Shaulian E, Karin M: AP-1 as a regulator of cell life and death. Nat Cell Biol. 2002, 4: E131-6. 10.1038/ncb0502-e131.
Article
CAS
PubMed
Google Scholar
Pollmann C, Huang X, Mall J, Bech-Otschir D, Naumann M, Dubiel W: The constitutive photomorphogenesis 9 signalosome directs vascular endothelial growth factor production in tumor cells. Cancer Res. 2001, 61: 8416-8421.
CAS
PubMed
Google Scholar
Henke W, Ferrell K, Bech-Otschir D, Seeger M, Schade R, Jungblut P, Naumann M, Dubiel W: Comparison of human COP9 signalsome and 26S proteasome lid'. Mol Biol Rep. 1999, 26: 29-34. 10.1023/A:1006991419464.
Article
CAS
PubMed
Google Scholar
Moos PJ, Edes K, Mullally JE, Fitzpatrick FA: Curcumin impairs tumor suppressor p53 function in colon cancer cells. Carcinogenesis. 2004, 25: 1611-1617. 10.1093/carcin/bgh163.
Article
CAS
PubMed
Google Scholar
Arbiser JL, Klauber N, Rohan R, van Leeuwen R, Huang MT, Fisher C, Flynn E, Byers HR: Curcumin is an in vivo inhibitor of angiogenesis. Mol Med. 1998, 4: 376-383.
CAS
PubMed
PubMed Central
Google Scholar
Thimm M, Goede A, Hougardy S, Preissner R: Comparison of 2D similarity and 3D superposition. Application to searching a conformational drug database. J Chem Inf Comput Sci. 2004, 44: 1816-1822. 10.1021/ci049920h.
Article
CAS
PubMed
Google Scholar
Chen X, Reynolds CH: Performance of similarity measures in 2D fragment-based similarity searching: comparison of structural descriptors and similarity coefficients. J Chem Inf Comput Sci. 2002, 42: 1407-1414. 10.1021/ci025531g.
Article
CAS
PubMed
Google Scholar
Lipinski CA: Drug-like properties and the causes of poor solubility and poor permeability. J Pharmacol Toxicol Methods. 2000, 44: 235-249. 10.1016/S1056-8719(00)00107-6.
Article
CAS
PubMed
Google Scholar
http://www.accelrys.com/dstudio: Discovery Studio, Accelrys: http://www.accelrys.com/dstudio. Discovery Studio Accelrys.
Snyder RD, Pearl GS, Mandakas G, Choy WN, Goodsaid F, Rosenblum IY: Assessment of the sensitivity of the computational programs DEREK, TOPKAT, and MCASE in the prediction of the genotoxicity of pharmaceutical molecules. Environ Mol Mutagen. 2004, 43: 143-158. 10.1002/em.20013.
Article
CAS
PubMed
Google Scholar
Liu R, Hsieh CY, Lam KS: New approaches in identifying drugs to inactivate oncogene products. Semin Cancer Biol. 2004, 14: 13-21. 10.1016/j.semcancer.2003.11.003.
Article
PubMed
Google Scholar
Hoppe-Seyler F, Butz K: Repression of endogenous p53 transactivation function in HeLa cervical carcinoma cells by human papillomavirus type 16 E6, human mdm-2, and mutant p53. J Virol. 1993, 67: 3111-3117.
CAS
PubMed
PubMed Central
Google Scholar
Wesierska-Gadek J, Schloffer D, Kotala V, Horky M: Escape of p53 protein from E6-mediated degradation in HeLa cells after cisplatin therapy. Int J Cancer. 2002, 101: 128-136. 10.1002/ijc.10580.
Article
CAS
PubMed
Google Scholar
Athanassiou M, Hu Y, Jing L, Houle B, Zarbl H, Mikheev AM: Stabilization and reactivation of the p53 tumor suppressor protein in nontumorigenic revertants of HeLa cervical cancer cells. Cell Growth Differ. 1999, 10: 729-737.
CAS
PubMed
Google Scholar
Elledge RM, Lock-Lim S, Allred DC, Hilsenbeck SG, Cordner L: p53 mutation and tamoxifen resistance in breast cancer. Clin Cancer Res. 1995, 1: 1203-1208.
CAS
PubMed
Google Scholar
Choudhuri T, Pal S, Agwarwal ML, Das T, Sa G: Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction. FEBS Lett. 2002, 512: 334-340. 10.1016/S0014-5793(02)02292-5.
Article
CAS
PubMed
Google Scholar
Kast WM, Offringa R, Peters PJ, Voordouw AC, Meloen RH, van der Eb AJ, Melief CJ: Eradication of adenovirus E1-induced tumors by E1A-specific cytotoxic T lymphocytes. Cell. 1989, 59: 603-614. 10.1016/0092-8674(89)90006-8.
Article
CAS
PubMed
Google Scholar
Shieh DE, Chen YY, Yen MH, Chiang LC, Lin CC: Emodin-induced apoptosis through p53-dependent pathway in human hepatoma cells. Life Sci. 2004, 74: 2279-2290. 10.1016/j.lfs.2003.09.060.
Article
CAS
PubMed
Google Scholar
Liontas A, Yeger H: Curcumin and resveratrol induce apoptosis and nuclear translocation and activation of p53 in human neuroblastoma. Anticancer Res. 2004, 24: 987-998.
CAS
PubMed
Google Scholar
Youssef KM, El-Sherbeny MA: Synthesis and antitumor activity of some curcumin analogs. Arch Pharm (Weinheim). 2005, 338: 181-189. 10.1002/ardp.200400939.
Article
CAS
Google Scholar
Adams BK, Cai J, Armstrong J, Herold M, Lu YJ, Sun A, Snyder JP, Liotta DC, Jones DP, Shoji M: EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism. Anticancer Drugs. 2005, 16: 263-275. 10.1097/00001813-200503000-00005.
Article
CAS
PubMed
Google Scholar
Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C: A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods. 1995, 184: 39-51. 10.1016/0022-1759(95)00072-I.
Article
CAS
PubMed
Google Scholar
Jenkins JL, Kao RY, Shapiro R: Virtual screening to enrich hit lists from high-throughput screening: a case study on small-molecule inhibitors of angiogenin. Proteins. 2003, 50: 81-93. 10.1002/prot.10270.
Article
CAS
PubMed
Google Scholar
Stahura FL, Bajorath J: Virtual screening methods that complement HTS. Comb Chem High Throughput Screen. 2004, 7: 259-269.
Article
CAS
PubMed
Google Scholar
Graham DL, Bevan N, Lowe PN, Palmer M, Rees S: Application of beta-galactosidase enzyme complementation technology as a high throughput screening format for antagonists of the epidermal growth factor receptor. J Biomol Screen. 2001, 6: 401-411.
CAS
PubMed
Google Scholar
Yim H, Lee YH, Lee CH, Lee SK: Emodin, an anthraquinone derivative isolated from the rhizomes of Rheum palmatum, selectively inhibits the activity of casein kinase II as a competitive inhibitor. Planta Med. 1999, 65: 9-13. 10.1055/s-1999-13953.
Article
CAS
PubMed
Google Scholar
Sarno S, Moro S, Meggio F, Zagotto G, Dal Ben D, Ghisellini P, Battistutta R, Zanotti G, Pinna LA: Toward the rational design of protein kinase casein kinase-2 inhibitors. Pharmacol Ther. 2002, 93: 159-168. 10.1016/S0163-7258(02)00185-7.
Article
CAS
PubMed
Google Scholar
Huang MT, Lou YR, Ma W, Newmark HL, Reuhl KR, Conney AH: Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice. Cancer Res. 1994, 54: 5841-5847.
CAS
PubMed
Google Scholar
Bai X, Cerimele F, Ushio-Fukai M, Waqas M, Campbell PM, Govindarajan B, Der CJ, Battle T, Frank DA, Ye K, Murad E, Dubiel W, Soff G, Arbiser JL: Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J Biol Chem. 2003, 278: 35501-35507. 10.1074/jbc.M302967200.
Article
CAS
PubMed
Google Scholar
Li L, Aggarwal BB, Shishodia S, Abbruzzese J, Kurzrock R: Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis. Cancer. 2004, 101: 2351-2362. 10.1002/cncr.20605.
Article
CAS
PubMed
Google Scholar