Table 1 Creation of two groups of potential inhibitors of CSN-associated kinases. The structures found in the database by 3D and 2D screening were divided into two groups (curcumin-group and emodin-group) depending on the lead structures curcumin or emodin. The analysis of the 2D structures abet the division into the two groups. The double line marks the threshold, which normally limits the hits (2D similarity <85%).