Nahta R, Yu D, Hung MC, Hortobagyi GN, Esteva FJ: Mechanisms of Disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol. 2006, 3: 269-280. 10.1038/ncponc0509.
Kleinberg DL, Wood TL, Furth PA, Lee AV: Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions. Endocr Rev. 2009, 30: 51-74.
Arteaga C, Kitten K, Coronado E: Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice. J Clin Invest. 1989, 84: 1418-1423. 10.1172/JCI114315.
Burtrum D, Zhu Z, Lu D, Anderson DM, Prewett M, Pereira DS, et al: A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo. Cancer Res. 2003, 63: 8912-8921.
Chernicky CL, Yi L, Tan H, Gan SU, Ilan J: Treatment of human breast cancer cells with antisense RNA to the type I insulin-like growth factor receptor inhibits cell growth, suppresses tumorigenesis, alters the metastatic potential, and prolongs survival in vivo. Cancer Gene Ther. 2000, 7: 384-395. 10.1038/sj.cgt.7700126.
Chernicky CL, Tan H, Yi L, Loret dM, Ilan J: Treatment of murine breast cancer cells with antisense RNA to the type I insulin-like growth factor receptor decreases the level of plasminogen activator transcripts, inhibits cell growth in vitro, and reduces tumorigenesis in vivo. Mol Pathol. 2002, 55: 102-109. 10.1136/mp.55.2.102.
Salatino M, Schillaci R, Proietti CJ, Carnevale R, Frahm I, Molinolo AA, et al: Inhibition of in vivo breast cancer growth by antisense oligodeoxynucleotides to type I insulin-like growth factor receptor mRNA involves inactivation of ErbBs, PI-3 K/Akt and p42/p44 MAPK signaling pathways but not modulation of progesterone receptor activity. Oncogene. 2004, 23: 5161-5174. 10.1038/sj.onc.1207659.
Law JH, Habibi G, Hu K, Masoudi H, Wang MY, Stratford AL, et al: Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival. Cancer Res. 2008, 68: 10238-10246. 10.1158/0008-5472.CAN-08-2755.
Gualberto A, Pollak M: Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions. Oncogene. 2009, 28: 3009-3021. 10.1038/onc.2009.172.
Weroha SJ, Haluska P: IGF-1 receptor inhibitors in clinical trials--early lessons. J Mammary Gland Biol Neoplasia. 2008, 13: 471-483. 10.1007/s10911-008-9104-6.
Byron SA, Yee D: Potential therapeutic strategies to interrupt insulin-like growth factor signaling in breast cancer. Semin Oncol. 2003, 30: 125-132.
Jones RA, Campbell CI, Gunther EJ, Chodosh LA, Petrik JJ, Khokha R, et al: Transgenic overexpression of IGF-IR disrupts mammary ductal morphogenesis and induces tumor formation. Oncogene. 2007, 26: 1636-1644. 10.1038/sj.onc.1209955.
Jones RA, Campbell CI, Wood GA, Petrik JJ, Moorehead RA: Reversibility and recurrence of IGF-IR-induced mammary tumors. Oncogene. 2008, 13: 407-413.
Franks SE, Campbell CI, Barnett EF, Siwicky MD, Livingstone J, Cory S, et al: Transgenic IGF-IR overexpression induces mammary tumors with basal-like characteristics while IGF-IR independent mammary tumors express a claudin-low gene signature. Oncogene. 2011
Alvarez RH, Kantarjian HM, Cortes JE: Biology of platelet-derived growth factor and its involvement in disease. Mayo Clin Proc. 2006, 81: 1241-1257. 10.4065/81.9.1241.
Fredriksson L, Li H, Eriksson U: The PDGF family: four gene products form five dimeric isoforms. Cytokine Growth Factor Rev. 2004, 15: 197-204. 10.1016/j.cytogfr.2004.03.007.
Betsholtz C: Biology of platelet-derived growth factors in development. Birth Defects Res C Embryo Today. 2003, 69: 272-285. 10.1002/bdrc.10030.
Yu J, Ustach C, Kim HR: Platelet-derived growth factor signaling and human cancer. J Biochem Mol Biol. 2003, 36: 49-59. 10.5483/BMBRep.2003.36.1.049.
Bhardwaj B, Klassen J, Cossette N, Sterns E, Tuck A, Deeley R, et al: Localization of platelet-derived growth factor beta receptor expression in the periepithelial stroma of human breast carcinoma. Clin Cancer Res. 1996, 2: 773-782.
Coltrera MD, Wang J, Porter PL, Gown AM: Expression of platelet-derived growth factor B-chain and the platelet-derived growth factor receptor beta subunit in human breast tissue and breast carcinoma. Cancer Res. 1995, 55: 2703-2708.
Carvalho I, Milanezi F, Martins A, Reis RM, Schmitt F: Overexpression of platelet-derived growth factor receptor alpha in breast cancer is associated with tumour progression. Breast Cancer Res. 2005, 7: R788-R795. 10.1186/bcr1304.
Jechlinger M, Sommer A, Moriggl R, Seither P, Kraut N, Capodiecci P, et al: Autocrine PDGFR signaling promotes mammary cancer metastasis. J Clin Invest. 2006, 116: 1561-1570. 10.1172/JCI24652.
Paulsson Y, Hammacher A, Heldin CH, Westermark B: Possible positive autocrine feedback in the prereplicative phase of human fibroblasts. Nature. 1987, 328: 715-717. 10.1038/328715a0.
Jones RA, Campbell CI, Petrik JJ, Moorehead RA: Characterization of a novel primary mammary tumor cell line reveals that cyclin D1 is regulated by the type I insulin-like growth factor receptor. Mol Cancer Res. 2008, 6: 819-828. 10.1158/1541-7786.MCR-07-2157.
Linnerth NM, Baldwin M, Campbell C, Brown M, McGowan H, Moorehead RA: IGF-II induces CREB phosphorylation and cell survival in human lung cancer cells. Oncogene. 2005
Salvioli S, Ardizzoni A, Franceschi C, Cossarizza A: JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis. FEBS Lett. 1997, 411: 77-82. 10.1016/S0014-5793(97)00669-8.
Huang F, Hurlburt W, Greer A, Reeves KA, Hillerman S, Chang H, et al: Differential mechanisms of acquired resistance to insulin-like growth factor-i receptor antibody therapy or to a small-molecule inhibitor, BMS-754807, in a human rhabdomyosarcoma model. Cancer Res. 2010, 70: 7221-7231. 10.1158/0008-5472.CAN-10-0391.
Tarn C, Rink L, Merkel E, Flieder D, Pathak H, Koumbi D, et al: Insulin-like growth factor 1 receptor is a potential therapeutic target for gastrointestinal stromal tumors. Proc Natl Acad Sci USA. 2008, 105: 8387-8392. 10.1073/pnas.0803383105.
Siegbahn A, Hammacher A, Westermark B, Heldin CH: Differential effects of the various isoforms of platelet-derived growth factor on chemotaxis of fibroblasts, monocytes, and granulocytes. J Clin Invest. 1990, 85: 916-920. 10.1172/JCI114519.
Vassbotn FS, Ostman A, Siegbahn A, Holmsen H, Heldin CH: Neomycin is a platelet-derived growth factor (PDGF) antagonist that allows discrimination of PDGF alpha- and beta-receptor signals in cells expressing both receptor types. J Biol Chem. 1992, 267: 15635-15641.
Wennstrom S, Siegbahn A, Yokote K, Arvidsson AK, Heldin CH, Mori S, et al: Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase. Oncogene. 1994, 9: 651-660.
Ahmad A, Wang Z, Kong D, Ali R, Ali S, Banerjee S, et al: Platelet-derived growth factor-D contributes to aggressiveness of breast cancer cells by up-regulating Notch and NF-kappaB signaling pathways. Breast Cancer Res Treat. 2011, 126: 15-25. 10.1007/s10549-010-0883-2.
Kang DW, Min dS: Platelet derived growth factor increases phospholipase D1 but not phospholipase D2 expression via NFkappaB signaling pathway and enhances invasion of breast cancer cells. Cancer Lett. 2010, 294: 125-133. 10.1016/j.canlet.2010.01.031.
Ostman A: PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma. Cytokine Growth Factor Rev. 2004, 15: 275-286. 10.1016/j.cytogfr.2004.03.002.
Ostman A, Heldin CH: PDGF receptors as targets in tumor treatment. Adv Cancer Res. 2007, 97: 247-274.
Faraone D, Aguzzi MS, Toietta G, Facchiano AM, Facchiano F, Magenta A, et al: Platelet-derived growth factor-receptor alpha strongly inhibits melanoma growth in vitro and in vivo. Neoplasia. 2009, 11: 732-742.
McCarty MF, Somcio RJ, Stoeltzing O, Wey J, Fan F, Liu W, et al: Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content. J Clin Invest. 2007, 117: 2114-2122. 10.1172/JCI31334.
Rosenkranz S, Kazlauskas A: Evidence for distinct signaling properties and biological responses induced by the PDGF receptor alpha and beta subtypes. Growth Factors. 1999, 16: 201-216. 10.3109/08977199909002130.
Brazil DP, Hemmings BA: Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem Sci. 2001, 26: 657-664. 10.1016/S0968-0004(01)01958-2.
Manning BD, Cantley LC: AKT/PKB signaling: navigating downstream. Cell. 2007, 129: 1261-1274. 10.1016/j.cell.2007.06.009.
Toker A, Yoeli-Lerner M: Akt signaling and cancer: surviving but not moving on. Cancer Res. 2006, 66: 3963-3966. 10.1158/0008-5472.CAN-06-0743.
Huang F, Greer A, Hurlburt W, Han X, Hafezi R, Wittenberg GM, et al: The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors. Cancer Res. 2009, 69: 161-170. 10.1158/0008-5472.CAN-08-0835.
Hou X, Huang F, Carboni JM, Flatten K, Asmann YW, Ten EC, et al: Drug efflux by breast cancer resistance protein is a mechanism of resistance to the benzimidazole insulin-like growth factor receptor/insulin receptor inhibitor, BMS-536924. Mol Cancer Ther. 2011, 10: 117-125. 10.1158/1535-7163.MCT-10-0438.
Abraham J, Prajapati SI, Nishijo K, Schaffer BS, Taniguchi E, Kilcoyne A, et al: Evasion mechanisms to Igf1r inhibition in rhabdomyosarcoma. Mol Cancer Ther. 2011, 10: 697-707. 10.1158/1535-7163.MCT-10-0695.
Campbell CI, Thompson DE, Siwicky MD, Moorehead RA: Murine mammary tumor cells with a claudin-low genotype. Cancer Cell International. 2011, 11: 28-10.1186/1475-2867-11-28.
Herschkowitz JI, Simin K, Weigman VJ, Mikaelian I, Usary J, Hu Z, et al: Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol. 2007, 8: R76-10.1186/gb-2007-8-5-r76.
Prat A, Parker JS, Karginova O, Fan C, Livasy C, Herschkowitz JI, et al: Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer. Breast Cancer Res. 2010, 12: R68-10.1186/bcr2635.