Table 1 Expression of PDGFR transcripts after suppression of IGF-IR levels
RM11A cell line (in vitro) | IGF-IR | PDGFRα | PDGFRβ |
|---|---|---|---|
with doxycycline | 1.000 ± 0.000 | 1.000 ± 0.000 | 1.000 ± 0.000 |
without doxycycline | 0.042 ± 0.024 | 1.608 ± 1.087 | 2.953 ± 0.534 |
MTB-IGFIR transgenic (in vivo) | |||
Control | 1.000 ± 0.223 | 1.000 ± 0.392 | 1.000 ± 0.210 |
24 h doxycycline withdrawal | 0.010 ± 0.006 | 3.113 ± 1.620 | 3.193 ± 0.948 |
48 h doxycycline withdrawal | 0.004 ± 0.002 | 7.527 ± 2.475* | 2.917 ± 0.818 |