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Figure 1 | BMC Cancer

Figure 1

From: Mammary tumors that become independent of the type I insulin-like growth factor receptor express elevated levels of platelet-derived growth factor receptors

Figure 1

IGF-IR independence is associated with upregulation of PDGFRs. Spindle recurrent tumors, formed after doxycycline withdrawal from MTB-IGFIR mice harbouring tumors and subsequent tumor regression, were compared to primary mammary tumors in which the IGF-IR transgene was expressed. Western blotting revealed an upregulation in PDGFRα and PDGFRβ in spindle recurrent tumors (a). For the western blots, β-actin served as a loading control. Immunohistochemistry was also used to examine PDGFR expression in two different primary mammary tumors (b-e) and in two different IGF-IR independent recurrent tumors (f-i). Scale bar = 100 μm.

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BMC Cancer

ISSN: 1471-2407

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