Antoniou AC, Gayther SA, Stratton JF, Ponder BA, Easton DF: Risk models for familial ovarian and breast cancer. Genet Epidemiol. 2000, 18 (2): 173-190. 10.1002/(SICI)1098-2272(200002)18:2<173::AID-GEPI6>3.0.CO;2-R.
Article
CAS
PubMed
Google Scholar
Ford D, Easton DF, Bishop DT, Narod SA, Goldgar DE: Risks of cancer in BRCA1-mutation carriers. Breast Cancer Linkage Consortium. Lancet. 1994, 343 (8899): 692-695. 10.1016/S0140-6736(94)91578-4.
Article
CAS
PubMed
Google Scholar
Ford D, Easton DF, Stratton M, Narod S, Goldgar D, Devilee P, Bishop DT, Weber B, Lenoir G, Chang-Claude J, Sobol H, Teare MD, Struewing J, Arason A, Scherneck S, Peto J, Rebbeck TR, Tonin P, Neuhausen S, Barkardottir R, Eyfjord J, Lynch H, Ponder BAJ, Gayther SA, Birch JM, Lindblom A, Stoppa-Lyonnet D, Bignon Y, Borg A, Hamann U, et al: Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium. Am J Hum Genet. 1998, 62 (3): 676-689. 10.1086/301749.
Article
CAS
PubMed
PubMed Central
Google Scholar
Satagopan JM, Offit K, Foulkes W, Robson ME, Wacholder S, Eng CM, Karp SE, Begg CB: The lifetime risks of breast cancer in Ashkenazi Jewish carriers of BRCA1 and BRCA2 mutations. Cancer Epidemiol Biomarkers Prev. 2001, 10 (5): 467-473.
CAS
PubMed
Google Scholar
Struewing JP, Hartge P, Wacholder S, Baker SM, Berlin M, McAdams M, Timmerman MM, Brody LC, Tucker MA: The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews. N Engl J Med. 1997, 336 (20): 1401-1408. 10.1056/NEJM199705153362001.
Article
CAS
PubMed
Google Scholar
Rosen EM, Fan S, Pestell RG, Goldberg ID: BRCA1 gene in breast cancer. J Cell Physiol. 2003, 196 (1): 19-41. 10.1002/jcp.10257.
Article
CAS
PubMed
Google Scholar
Futreal PA, Liu Q, Shattuck-Eidens D, Cochran C, Harshman K, Tavtigian S, Bennett LM, Haugen-Strano A, Swensen J, Miki Y, Eddington K, McClure M, Frye C, Weaver-Feldhaus J, Ding W, Gholami Z, Söderkvist P, Terry L, Jhanwar S, Berchuck A, Iglehart JD, Marks J, Ballinger DG, Barrett JC, Skolnick MH, Kamb A, Wiseman RW: BRCA1 mutations in primary breast and ovarian carcinomas. Science. 1994, 266 (5182): 120-122. 10.1126/science.7939630.
Article
CAS
PubMed
Google Scholar
Lancaster JM, Wooster R, Mangion J, Phelan CM, Cochran C, Gumbs C, Seal S, Barfoot R, Collins N, Bignell G, Patel S, Hamoudi R, Larsson C, Wiseman RW, Berchuck A, Iglehart JD, Marks JR, Ashworth A, Stratton MR, Futreal PA: BRCA2 mutations in primary breast and ovarian cancers. Nat Genet. 1996, 13 (2): 238-240. 10.1038/ng0696-238.
Article
CAS
PubMed
Google Scholar
Wei M, Grushko TA, Dignam J, Hagos F, Nanda R, Sveen L, Xu J, Fackenthal J, Tretiakova M, Das S, Olopade OI: BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy. Cancer Res. 2005, 65 (23): 10692-10699. 10.1158/0008-5472.CAN-05-1277.
Article
CAS
PubMed
Google Scholar
Butcher DT, Rodenhiser DI: Epigenetic inactivation of BRCA1 is associated with aberrant expression of CTCF and DNA methyltransferase (DNMT3B) in some sporadic breast tumours. Eur J Cancer. 2007, 43 (1): 210-219. 10.1016/j.ejca.2006.09.002.
Article
CAS
PubMed
Google Scholar
Xu CF, Brown MA, Nicolai H, Chambers JA, Griffiths BL, Solomon E: Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene. Hum Mol Genet. 1997, 6 (7): 1057-1062. 10.1093/hmg/6.7.1057.
Article
CAS
PubMed
Google Scholar
Suen TC, Goss PE: Transcription of BRCA1 is dependent on the formation of a specific protein-DNA complex on the minimal BRCA1 Bi-directional promoter. J Biol Chem. 1999, 274 (44): 31297-31304. 10.1074/jbc.274.44.31297.
Article
CAS
PubMed
Google Scholar
Thakur S, Croce CM: Positive regulation of the BRCA1 promoter. J Biol Chem. 1999, 274 (13): 8837-8843. 10.1074/jbc.274.13.8837.
Article
CAS
PubMed
Google Scholar
Thakur S, Nakamura T, Calin G, Russo A, Tamburrino JF, Shimizu M, Baldassarre G, Battista S, Fusco A, Wassell RP, Dubois G, Alder H, Croce CM: Regulation of BRCA1 transcription by specific single-stranded DNA binding factors. Mol Cell Biol. 2003, 23 (11): 3774-3787. 10.1128/MCB.23.11.3774-3787.2003.
Article
CAS
PubMed
PubMed Central
Google Scholar
Atlas E, Stramwasser M, Whiskin K, Mueller CR: GA-binding protein alpha/beta is a critical regulator of the BRCA1 promoter. Oncogene. 2000, 19 (15): 1933-1940. 10.1038/sj.onc.1203516.
Article
CAS
PubMed
Google Scholar
Atlas E, Stramwasser M, Mueller CR: A CREB site in the BRCA1 proximal promoter acts as a constitutive transcriptional element. Oncogene. 2001, 20 (48): 7110-7114. 10.1038/sj.onc.1204890.
Article
CAS
PubMed
Google Scholar
Mancini DN, Rodenhiser DI, Ainsworth PJ, O'Malley FP, Singh SM, Xing W, Archer TK: CpG methylation within the 5' regulatory region of the BRCA1 gene is tumor specific and includes a putative CREB binding site. Oncogene. 1998, 16 (9): 1161-1169. 10.1038/sj.onc.1201630.
Article
CAS
PubMed
Google Scholar
Bindra RS, Gibson SL, Meng A, Westermark U, Jasin M, Pierce AJ, Bristow RG, Classon MK, Glazer PM: Hypoxia-induced down-regulation of BRCA1 expression by E2Fs. Cancer Res. 2005, 65 (24): 11597-11604. 10.1158/0008-5472.CAN-05-2119.
Article
CAS
PubMed
Google Scholar
Bindra RS, Glazer PM: Basal repression of BRCA1 by multiple E2Fs and pocket proteins at adjacent E2F sites. Cancer Biol Ther. 2006, 5 (10): 1400-1407. 10.4161/cbt.5.10.3454.
Article
CAS
PubMed
Google Scholar
De Siervi A, De Luca P, Byun JS, Di LJ, Fufa T, Haggerty CM, Vazquez E, Moiola C, Longo DL, Gardner K: Transcriptional autoregulation by BRCA1. Cancer Res. 70 (2): 532-542.
Rauch T, Zhong X, Pfeifer GP, Xu X: 53BP1 is a positive regulator of the BRCA1 promoter. Cell Cycle. 2005, 4 (8): 1078-1083.
Article
CAS
PubMed
Google Scholar
Jeffy BD, Hockings JK, Kemp MQ, Morgan SS, Hager JA, Beliakoff J, Whitesell LJ, Bowden GT, Romagnolo DF: An estrogen receptor-alpha/p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors: repressive effects of p53 on BRCA-1 transcription. Neoplasia. 2005, 7 (9): 873-882. 10.1593/neo.05256.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hockings JK, Thorne PA, Kemp MQ, Morgan SS, Selmin O, Romagnolo DF: The ligand status of the aromatic hydrocarbon receptor modulates transcriptional activation of BRCA-1 promoter by estrogen. Cancer Res. 2006, 66 (4): 2224-2232. 10.1158/0008-5472.CAN-05-1619.
Article
CAS
PubMed
Google Scholar
Wardrop SL, Brown MA: Identification of two evolutionarily conserved and functional regulatory elements in intron 2 of the human BRCA1 gene. Genomics. 2005, 86 (3): 316-328. 10.1016/j.ygeno.2005.05.006.
Article
CAS
PubMed
Google Scholar
Dang CV, O'Donnell KA, Zeller KI, Nguyen T, Osthus RC, Li F: The c-Myc target gene network. Semin Cancer Biol. 2006, 16 (4): 253-264. 10.1016/j.semcancer.2006.07.014.
Article
CAS
PubMed
Google Scholar
Solomon DL, Amati B, Land H: Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers. Nucleic Acids Res. 1993, 21 (23): 5372-5376. 10.1093/nar/21.23.5372.
Article
CAS
PubMed
PubMed Central
Google Scholar
Menssen A, Hermeking H: Characterization of the c-MYC-regulated transcriptome by SAGE: identification and analysis of c-MYC target genes. Proc Natl Acad Sci USA. 2002, 99 (9): 6274-6279. 10.1073/pnas.082005599.
Article
CAS
PubMed
PubMed Central
Google Scholar
Esteller M: Epigenetic lesions causing genetic lesions in human cancer: promoter hypermethylation of DNA repair genes. Eur J Cancer. 2000, 36 (18): 2294-2300. 10.1016/S0959-8049(00)00303-8.
Article
CAS
PubMed
Google Scholar
Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001, 25 (4): 402-408. 10.1006/meth.2001.1262.
Article
CAS
PubMed
Google Scholar
Weng L, Zhu C, Xu J, Du W: Critical role of active repression by E2F and Rb proteins in endoreplication during Drosophila development. Embo J. 2003, 22 (15): 3865-3875. 10.1093/emboj/cdg373.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pierce AJ, Jasin M: Measuring recombination proficiency in mouse embryonic stem cells. Methods Mol Biol. 2005, 291: 373-384.
CAS
PubMed
Google Scholar
Sy SM, Huen MS, Zhu Y, Chen J: PALB2 regulates recombinational repair through chromatin association and oligomerization. J Biol Chem. 2009, 284 (27): 18302-18310. 10.1074/jbc.M109.016717.
Article
CAS
PubMed
PubMed Central
Google Scholar
Xu J, Huo D, Chen Y, Nwachukwu C, Collins C, Rowell J, Slamon DJ, Olopade OI: CpG island methylation affects accessibility of the proximal BRCA1 promoter to transcription factors. Breast Cancer Res Treat. 2009
Google Scholar
Scully R, Ganesan S, Vlasakova K, Chen J, Socolovsky M, Livingston DM: Genetic analysis of BRCA1 function in a defined tumor cell line. Mol Cell. 1999, 4 (6): 1093-1099. 10.1016/S1097-2765(00)80238-5.
Article
CAS
PubMed
Google Scholar
Fernandez PC, Frank SR, Wang L, Schroeder M, Liu S, Greene J, Cocito A, Amati B: Genomic targets of the human c-Myc protein. Genes Dev. 2003, 17 (9): 1115-1129. 10.1101/gad.1067003.
Article
CAS
PubMed
PubMed Central
Google Scholar
Patel JH, Loboda AP, Showe MK, Showe LC, McMahon SB: Analysis of genomic targets reveals complex functions of MYC. Nat Rev Cancer. 2004, 4 (7): 562-568. 10.1038/nrc1393.
Article
CAS
PubMed
Google Scholar
Cappellen D, Schlange T, Bauer M, Maurer F, Hynes NE: Novel c-MYC target genes mediate differential effects on cell proliferation and migration. EMBO Rep. 2007, 8 (1): 70-76. 10.1038/sj.embor.7400849.
Article
CAS
PubMed
Google Scholar
Benassi B, Fanciulli M, Fiorentino F, Porrello A, Chiorino G, Loda M, Zupi G, Biroccio A: c-Myc phosphorylation is required for cellular response to oxidative stress. Mol Cell. 2006, 21 (4): 509-519. 10.1016/j.molcel.2006.01.009.
Article
CAS
PubMed
Google Scholar
Koshiji M, Kageyama Y, Pete EA, Horikawa I, Barrett JC, Huang LE: HIF-1alpha induces cell cycle arrest by functionally counteracting Myc. Embo J. 2004, 23 (9): 1949-1956. 10.1038/sj.emboj.7600196.
Article
CAS
PubMed
PubMed Central
Google Scholar
Reisman D, Elkind NB, Roy B, Beamon J, Rotter V: c-Myc trans-activates the p53 promoter through a required downstream CACGTG motif. Cell Growth Differ. 1993, 4 (2): 57-65.
CAS
PubMed
Google Scholar
Ho JS, Ma W, Mao DY, Benchimol S: p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrest. Mol Cell Biol. 2005, 25 (17): 7423-7431. 10.1128/MCB.25.17.7423-7431.2005.
Article
CAS
PubMed
PubMed Central
Google Scholar
Angeloni SV, Martin MB, Garcia-Morales P, Castro-Galache MD, Ferragut JA, Saceda M: Regulation of estrogen receptor-alpha expression by the tumor suppressor gene p53 in MCF-7 cells. J Endocrinol. 2004, 180 (3): 497-504. 10.1677/joe.0.1800497.
Article
CAS
PubMed
Google Scholar
Dubik D, Dembinski TC, Shiu RP: Stimulation of c-myc oncogene expression associated with estrogen-induced proliferation of human breast cancer cells. Cancer Res. 1987, 47 (24 Pt 1): 6517-6521.
CAS
PubMed
Google Scholar
Park KJ, Krishnan V, O'Malley BW, Yamamoto Y, Gaynor RB: Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation. Mol Cell. 2005, 18 (1): 71-82. 10.1016/j.molcel.2005.03.006.
Article
CAS
PubMed
Google Scholar
Qin C, Nguyen T, Stewart J, Samudio I, Burghardt R, Safe S: Estrogen up-regulation of p53 gene expression in MCF-7 breast cancer cells is mediated by calmodulin kinase IV-dependent activation of a nuclear factor kappaB/CCAAT-binding transcription factor-1 complex. Mol Endocrinol. 2002, 16 (8): 1793-1809. 10.1210/me.2002-0006.
Article
CAS
PubMed
Google Scholar
Deng CX: BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution. Nucleic Acids Res. 2006, 34 (5): 1416-1426. 10.1093/nar/gkl010.
Article
CAS
PubMed
PubMed Central
Google Scholar
Grushko TA, Dignam JJ, Das S, Blackwood AM, Perou CM, Ridderstrale KK, Anderson KN, Wei MJ, Adams AJ, Hagos FG, Sveen L, Lynch HT, Weber BL, Olopade OI: MYC is amplified in BRCA1-associated breast cancers. Clin Cancer Res. 2004, 10 (2): 499-507. 10.1158/1078-0432.CCR-0976-03.
Article
CAS
PubMed
Google Scholar
Brenner C, Deplus R, Didelot C, Loriot A, Vire E, De Smet C, Gutierrez A, Danovi D, Bernard D, Boon T, Pelicci PG, Amati B, Kouzarides T, de Launoit Y, Di Croce L, Fuks F: Myc represses transcription through recruitment of DNA methyltransferase corepressor. Embo J. 2005, 24 (2): 336-346. 10.1038/sj.emboj.7600509.
Article
CAS
PubMed
Google Scholar
Ostler KR, Davis EM, Payne SL, Gosalia BB, Exposito-Cespedes J, Le Beau MM, Godley LA: Cancer cells express aberrant DNMT3B transcripts encoding truncated proteins. Oncogene. 2007, 26 (38): 5553-5563. 10.1038/sj.onc.1210351.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lin JC, Jeong S, Liang G, Takai D, Fatemi M, Tsai YC, Egger G, Gal-Yam EN, Jones PA: Role of nucleosomal occupancy in the epigenetic silencing of the MLH1 CpG island. Cancer Cell. 2007, 12 (5): 432-444. 10.1016/j.ccr.2007.10.014.
Article
CAS
PubMed
PubMed Central
Google Scholar
Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, Magri E, Pedriali M, Fabbri M, Campiglio M, Menard S, Palazzo JP, Rosenberg A, Musiani P, Volinia S, Nenci I, Calin GA, Querzoli P, Negrini M, Croce CM: MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 2005, 65 (16): 7065-7070. 10.1158/0008-5472.CAN-05-1783.
Article
CAS
PubMed
Google Scholar