Figure 3
From: c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells
A diagram of BRCA1 promoter region and the alignment of regions spanning putative E boxes in the BRCA1 distal promoter. (A) The diagram is an illustration only representing E boxes in BRCA1 gene distal promoter and is not to scale. Positions of putative E boxes are marked by boxes with vertical lines, and regions of BRCA1 exon 1a and 1b (partial) are marked by filled boxes. The locations are relative to the transcription start site of exon 1a as +1. (B) Nucleotides that are conserved between two of the E boxes (bold and italic) are shown as the deduced consensus sequence listed below, while variable nucleotides are marked with asterisks: *.