Jaffe N: Adjuvant chemotherapy in osteosarcoma: An odyssey of rejection and vindication. Pediatric and Adolescent Osteosarcoma, Cancer Treatment and Research. Edited by: Jaffe N, Bielack SS, Bruland OS. 2009, New York: Springer, 152:
Google Scholar
Dernell WS, Ehrhart NP, Straw RC, Vail DM: Tumors of the Skeletal System. Withrow and MacEwen's Small Animal Clinical Oncology. 2007, St. Louis: Saunders Elsevier, 540-567. full_text. 4
Chapter
Google Scholar
Bacon NJ, Ehrhart NP, Dernell WS, Lafferty M, Withrow SJ: Use of alternating administration of carboplatin and doxorubicin in dogs with microscopic metastases after amputation for appendicular osteosarcoma: 50 cases (1999-2006). JAVMA. 2008, 232 (10): 1504-1510.
Article
CAS
PubMed
Google Scholar
Chun R, Kurzman ID, Couto CG, Klausner J, Henry C, MacEwen EG: Cisplatin and doxorubicin combination chemotherapy for the treatment of canine osteosarcoma: a pilot study. Journal of Veterinary Internal Medicine. 2000, 14 (5): 495-498. 10.1111/j.1939-1676.2000.tb02265.x.
Article
CAS
PubMed
Google Scholar
Mauldin GN, Matus RE, Withrow SJ, Patnaik AK: Canine osteosarcoma: Treatment by amputation versus amputation and adjuvant chemotherapy using doxorubicin and cisplatin. Journal of Veterinary Internal Medicine. 1988, 2 (4): 177-180. 10.1111/j.1939-1676.1988.tb00313.x.
Article
CAS
PubMed
Google Scholar
Shapiro W, Fossum T, Kitchell B, Couto C, Theilen G: Use of cisplatin for treatment of appendicular osteosarcoma in dogs. JAVMA. 1988, 192 (4): 507-511.
CAS
PubMed
Google Scholar
Spodnick GJ, Berg J, Rand WM, Schelling SH, Couto G, Harvey HJ, Henderson RA, MacEwen G, Mauldin N, McCaw DL: Prognosis for dogs with appendicular osteosarcoma treated by amputation alone: 162 cases (1978-1988). JAVMA. 1992, 200 (7): 995-999.
CAS
PubMed
Google Scholar
Mueller F, Fuchs B, Kaser-Hotz B: Comparative biology of human and canine osteosarcoma. Anticancer Research. 2007, 27 (1A): 155-164.
CAS
PubMed
Google Scholar
Thomas R, Wang H, Tsai P, Langford C, Fosmire S, Jubala C, Getzy D, Cutter G, Modiano J, Breen M: Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma. Chromosome Research. 2009, 17 (3): 365-377. 10.1007/s10577-009-9028-z.
Article
CAS
PubMed
PubMed Central
Google Scholar
Paoloni M, Davis S, Lana S, Withrow S, Sangiorgi L, Picci P, Hewitt S, Triche T, Meltzer P, Khanna C: Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression. BMC Genomics. 2009, 10 (1): 625-10.1186/1471-2164-10-625.
Article
PubMed
PubMed Central
Google Scholar
Sutter NB, Ostrander EA: Dog star rising: the canine genetic system. Nature Reviews Genetics. 2004, 5 (12): 900-910. 10.1038/nrg1492.
Article
CAS
PubMed
Google Scholar
Fidler IJ: The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nature Reviews Cancer. 2003, 3 (6): 453-458. 10.1038/nrc1098.
Article
CAS
PubMed
Google Scholar
Van'tVeer LJ, Weigelt B: Road map to metastasis. Nature Medicine. 2003, 9 (8): 999-1000. 10.1038/nm0803-999b.
Article
Google Scholar
van de Vijver MJ, He YD, van 't Veer LJ, Dai H, Hart AAM, Voskuil DW, Schreiber GJ, Peterse JL, Roberts C, Marton MJ, Parrish M, Atsma D, Witteveen A, Glas A, Delahaye L, van der Velde T, Bartelink H, Rodenhuis S, Rutgers ET, Friend SH, Bernards R: A gene-expression signature as a predictor of survival in breast cancer. New England Journal of Medicine. 2002, 347 (25): 1999-2009. 10.1056/NEJMoa021967.
Article
CAS
PubMed
Google Scholar
Collins I, Workman P: New approaches to molecular cancer therapeutics. Nature Chemical Biology. 2006, 2 (12): 689-700. 10.1038/nchembio840.
Article
CAS
PubMed
Google Scholar
Varmus H: The New Era in Cancer Research. Science. 2006, 312 (5777): 1162-1165. 10.1126/science.1126758.
Article
CAS
PubMed
Google Scholar
Jeys L, Grimer R, Carter S, Tillman R, Abudu A: Post operative infection and increased survival in osteosarcoma patients: are they associated?. Annals of Surgical Oncology. 2007, 14 (10): 2887-2895. 10.1245/s10434-007-9483-8.
Article
CAS
PubMed
Google Scholar
Lascelles B, Dernell W, Correa M, Lafferty M, Devitt C, Kuntz C, Straw R, Withrow S: Improved survival associated with postoperative wound infection in dogs treated with limb-salvage surgery for osteosarcoma. Annals of Surgical Oncology. 2005, 12 (12): 1073-1083. 10.1245/ASO.2005.01.011.
Article
PubMed
Google Scholar
Affymetrix: Guide to Probe Logarithmic Intensity Error (PLIER) Estimation. 2005
Google Scholar
Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, Speed TP: Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 2003, 4 (2): 249-264. 10.1093/biostatistics/4.2.249.
Article
PubMed
Google Scholar
Weinstein JN, Myers TG, O'Connor PM, Friend SH AJF, Kohn KW, Fojo T, Bates SE, Rubinstein LV, Anderson NL, Buolamwini JK, Osdol WWv, Monks AP, Scudiero DA, Sausville EA, Zaharevitz DW, Bunow B, Viswanadhan VN, Johnson GS, Wittes RE, Paull KD: An information-intensive approach to the molecular pharmacology of cancer. Science. 1997, 275 (5298): 343-349. 10.1126/science.275.5298.343.
Article
CAS
PubMed
Google Scholar
Karolchik D, Baertsch R, Diekhans M, Furey TS, Hinrichs A, Lu YT, Roskin KM, Schwartz M, Sugnet CW, Thomas DJ, Weber RJ, Haussler D, Kent WJ: The UCSC Genome Browser Database. Nucl Acids Res. 2003, 31 (1): 51-54. 10.1093/nar/gkg129.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kent WJ: BLAT---The BLAST-Like Alignment Tool. Genome Research. 2002, 12 (4): 656-664.
Article
CAS
PubMed
PubMed Central
Google Scholar
Thomson SAM, Kennerly E, Olby N, Mickelson JR, Hoffmann DE, Dickinson PJ, Gibson G, Breen M: Microarray analysis of differentially expressed genes of primary tumors in the canine central nervous system. Veterinary Pathology. 2005, 42: 550-558. 10.1354/vp.42-5-550.
Article
CAS
PubMed
Google Scholar
Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCt method. Methods. 2001, 25 (4): 402-408. 10.1006/meth.2001.1262.
Article
CAS
PubMed
Google Scholar
Pfaffl MW: A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Research. 2001, 29 (9): e45-10.1093/nar/29.9.e45.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pfaffl MW, Horgan GW, Dempfle L: Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Research. 2002, 30 (9): e36-10.1093/nar/30.9.e36.
Article
PubMed
PubMed Central
Google Scholar
Ptitsyn A, Weil M, Thamm D: Systems biology approach to identification of biomarkers for metastatic progression in cancer. BMC Bioinformatics. 2008, 9 (Suppl 9): S8-10.1186/1471-2105-9-S9-S8.
Article
PubMed
PubMed Central
Google Scholar
Patel S, Lyons-Weiler J: caGEDA: a web application for the integrated analysis of global gene expression patterns in cancer. Applied Bioinformatics. 2004, 3 (1): 49-62. 10.2165/00822942-200403010-00007.
Article
CAS
PubMed
Google Scholar
Dennis G, Sherman B, Hosack D, Yang J, Gao W, Lane HC, Lempicki R: DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biology. 2003, 4 (5): P3-10.1186/gb-2003-4-5-p3.
Article
PubMed
Google Scholar
Huang DW, Sherman BT, Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protocols. 2008, 4 (1): 44-57. 10.1038/nprot.2008.211.
Article
Google Scholar
Witten I, Frank E: Data Mining: Practical machine learning tools and techniques. 2005, San Francisco: Morgan Kaufmann, 2
Google Scholar
Depeursinge A, Iavindrasana J, Hidki A, Cohen G, Geissbuhler A, Platon A, Poletti P, Müller H: Comparative performance analysis of state-of-the-art classification algorithms applied to lung tissue categorization. Journal of Digital Imaging. 2008,
Google Scholar
Lemm I, Ross J: Regulation of c-myc mRNA decay by translational pausing in a coding region instability determinant. Molecular and Cellular Biology. 2002, 22 (12): 3959-3969. 10.1128/MCB.22.12.3959-3969.2002.
Article
CAS
PubMed
PubMed Central
Google Scholar
Noubissi FK, Elcheva I, Bhatia N, Shakoori A, Ougolkov A, Liu J, Minamoto T, Ross J, Fuchs SY, Spiegelman VS: CRD-BP mediates stabilization of [beta]TrCP1 and c-myc mRNA in response to [beta]-catenin signalling. Nature. 2006, 441 (7095): 898-901. 10.1038/nature04839.
Article
CAS
PubMed
Google Scholar
Vikesaa J, Hansen TVO, Jønson L, Borup R, Wewer UM, Christiansen J, Nielsen FC: RNA-binding IMPs promote cell adhesion and invadopodia formation. The EMBO Journal. 2006, 25 (7): 1456-1468. 10.1038/sj.emboj.7601039.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC: A family of Insulin-Like Growth Factor II mRNA-binding proteins represses translation in late development. Molecular and Cellular Biology. 1999, 19 (2): 1262-1270.
Article
CAS
PubMed
PubMed Central
Google Scholar
Huttelmaier S, Zenklusen D, Lederer M, Dictenberg J, Lorenz M, Meng X, Bassell GJ, Condeelis J, Singer RH: Spatial regulation of [beta]-actin translation by Src-dependent phosphorylation of ZBP1. Nature. 2005, 438 (7067): 512-515. 10.1038/nature04115.
Article
PubMed
Google Scholar
Kobel M, Weidensdorfer D, Reinke C, Lederer M, Schmitt WD, Zeng K, Thomssen C, Hauptmann S, Huttelmaier S: Expression of the RNA-binding protein IMP1 correlates with poor prognosis in ovarian carcinoma. Oncogene. 2007, 26 (54): 7584-7589. 10.1038/sj.onc.1210563.
Article
CAS
PubMed
Google Scholar
Dimitriadis E, Trangas T, Milatos S, Foukas PG, Gioulbasanis I, Courtis N, Nielsen FC, Pandis N, Dafni U, Bardi G, Ioannidis P: Expression of oncofetal RNA-binding protein CRD-BP/IMP1 predicts clinical outcome in colon cancer. International Journal of Cancer. 2007, 121 (3): 486-494. 10.1002/ijc.22716.
Article
CAS
PubMed
Google Scholar
Yang Y, Tian X, Xie X, Zhuang Y, Wu W, Wang W: Expression and regulation of hedgehog signaling pathway in pancreatic cancer. Langenbeck's Archives of Surgery. 2009,
Google Scholar
Minuto F, Palermo C, Arvigo M, Barreca AM: The IGF system and bone. Journal of Endocrinological Investigation. 2005, 28 (8 Suppl): 8-10.
CAS
PubMed
Google Scholar
Voehringer DW, Hirschberg DL, Xiao J, Lu Q, Roederer M, Lock CB, Herzenberg LA, Steinman L, Herzenberg LA: Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis. Proceedings of the National Academy of Sciences. 2000, 97 (6): 2680-2685. 10.1073/pnas.97.6.2680.
Article
CAS
Google Scholar
Bigl M, Jandrig B, Horn L-C, Eschrich K: Aberrant methylation of human L- and M-fructose 1,6-bisphosphatase genes in cancer. Biochemical and Biophysical Research Communications. 2008, 377 (2): 720-724. 10.1016/j.bbrc.2008.10.045.
Article
CAS
PubMed
Google Scholar
Lyon RC, Johnston SM, Panopoulos A, Alzeer S, McGarvie G, Ellis EM: Enzymes involved in the metabolism of [gamma]-hydroxybutyrate in SH-SY5Y cells: Identification of an iron-dependent alcohol dehydrogenase ADHFe1. Chemico-Biological Interactions. 2009, 178 (1-3): 283-287. 10.1016/j.cbi.2008.10.025.
Article
CAS
PubMed
Google Scholar
Kobayashi S, Fukuhara A, Taguchi T, Matsuda M, Tochino Y, Otsuki M, Shimomura I: Identification of a new secretory factor, CCDC3/Favine, in adipocytes and endothelial cells. Biochemical and Biophysical Research Communications. 2010, 392 (1): 29-35. 10.1016/j.bbrc.2009.12.142.
Article
CAS
PubMed
Google Scholar
Bruheim S, Xi Y, Ju J, Fodstad O: Gene expression profiles classify human osteosarcoma xenografts according to sensitivity to doxorubicin, cisplatin, and ifosfamide. Clinical Cancer Research. 2009, 15 (23): 7161-7169. 10.1158/1078-0432.CCR-08-2816.
Article
CAS
PubMed
Google Scholar
Chionia A-M, Brackenburyb WJ, Calhounb JD, Isomb LL, Djamgoza MBA: A novel adhesion molecule in human breast cancer cells: Voltage-gated Na+ channel β1 subunit. The International Journal of Biochemistry & Cell Biology. 2009, 41 (5): 1216-1227.
Article
Google Scholar
Yao L, Zhang J, Liu X: NDRG2: a Myc-repressed gene involved in cancer and cell stress. Acta Biochimica et Biophysica Sinica. 2008, 40 (7): 625-635. 10.1111/j.1745-7270.2008.00434.x.
Article
CAS
PubMed
Google Scholar
Squire J, Pei J, Marrano P, Beheshti B, Bayani J, Lim G, Moldovan L, Zielenska M: High-resolution mapping of amplifications and deletions in pediatric osteosarcoma by use of CGH analysis of cDNA microarrays. Genes Chromosomes Cancer. 2003, 38 (3): 215-225. 10.1002/gcc.10273.
Article
CAS
PubMed
Google Scholar
Tepel M, Roerig P, Wolter M, Gutmann DH, Perry A, Reifenberger G, Riemenschneider MJ: Frequent promoter hypermethylation and transcriptional downregulation of the NDRG2 gene at 14q11.2 in primary glioblastoma. International Journal of Cancer. 2008, 123 (9): 2080-2086. 10.1002/ijc.23705.
Article
CAS
PubMed
Google Scholar
Kim YJ, Yoon SY, Kim J-T, Choi SC, Lim J-S, Kim JH, Song EY, Lee HG, Choi I, Kim JW: NDRG2 suppresses cell proliferation through down-regulation of AP-1 activity in human colon carcinoma cells. International Journal of Cancer. 2009, 124 (1): 7-15. 10.1002/ijc.23945.
Article
CAS
PubMed
Google Scholar
Kim A, Kim M-J, Yang Y, Kim JW, Yeom YI, Lim J-S: Suppression of NF-{kappa}B activity by NDRG2 expression attenuates the invasive potential of highly malignant tumor cells. Carcinogenesis. 2009,
Google Scholar
Liu N, Wang L, Li X, Yang Q, Liu X, Zhang J, Zhang J, Wu Y, Ji S, Zhang Y, Yang A, Han H, Yao L: N-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosis. Nucleic Acids Research. 2008, 36 (16): 5335-5349. 10.1093/nar/gkn504.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kim Y-J, Yoon SY, Kim J-T, Song EY, Lee HG, Son HJ, Kim SY, Cho D, Choi I, Kim JH, Kim JW: NDRG2 expression decreases with tumor stages and regulates TCF/{beta}-catenin signaling in human colon carcinoma. Carcinogenesis. 2009, 30 (4): 598-605. 10.1093/carcin/bgp047.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang X-Y, Pfeiffer HK, Nissim I, Daikhin E, Yudkoff M, McMahon SB, Thompson CB: Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proceedings of the National Academy of Sciences. 2008, 105 (48): 18782-18787. 10.1073/pnas.0810199105.
Article
CAS
Google Scholar
Naviglio S, Caraglia M, Abbruzzese A, Chiosi E, Gesto DD, Marra M, Romano M, Sorrentino A, Sorvillo L, Spina A, Illiano G: Protein kinase A as a biological target in cancer therapy. Expert Opinion on Therapeutic Targets. 2009, 13 (1): 83-92. 10.1517/14728220802602349.
Article
CAS
PubMed
Google Scholar
Day TF, Yang Y: Wnt and hedgehog signaling pathways in bone development. The Journal of Bone and Joint Surgery. 2008, 90 (Suppl 1): 19-24. 10.2106/JBJS.G.01174.
Article
PubMed
Google Scholar
Katoh Y, Katoh M: Comparative genomics on HHIP family orthologs. International Journal of Molecular Medicine. 2006, 17 (2): 391-395.
CAS
PubMed
Google Scholar
Tojo M, Kiyosawa H, Iwatsuki K, Kaneko F: Expression of a sonic hedgehog signal transducer, hedgehog-interacting protein, by human basal cell carcinoma. British Journal of Dermatology. 2002, 146 (1): 69-73. 10.1046/j.1365-2133.2002.04583.x.
Article
CAS
PubMed
Google Scholar
Olsen C, Hsu P-P, Glienke J, Rubanyi G, Brooks A: Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors. BMC Cancer. 2004, 4 (1): 43-53. 10.1186/1471-2407-4-43.
Article
PubMed
PubMed Central
Google Scholar
Man T-K, Chintagumpala M, Visvanathan J, Shen J, Perlaky L, Hicks J, Johnson M, Davino N, Murray J, Helman L, Meyer W, Triche T, Wong K-K, Lau CC: Expression profiles of osteosarcoma that can predict response to chemotherapy. Cancer Research. 2005, 65 (18): 8142-8150. 10.1158/0008-5472.CAN-05-0985.
Article
CAS
PubMed
Google Scholar
Mintz MB, Sowers R, Brown KM, Hilmer SC, Mazza B, Huvos AG, Meyers PA, LaFleur B, McDonough WS, Henry MM, Ramsey KE, Antonescu CR, Chen W, Healey JH, Daluski A, Berens ME, MacDonald TJ, Gorlick R, Stephan DA: An expression signature classifies chemotherapy-resistant pediatric osteosarcoma. Cancer Research. 2005, 65 (5): 1748-1754. 10.1158/0008-5472.CAN-04-2463.
Article
CAS
PubMed
Google Scholar
Ochi K, Daigo Y, Katagiri T, Nagayama S, Tsunoda T, Myoui A, Naka N, Araki N, Kudawara I, Ieguchi M, Toyama Y, Toguchida J, Yoshikawa H, Nakamura Y: Prediction of response to neoadjuvant chemotherapy for osteosarcoma by gene-expression profiles. International Journal of Oncology. 2004, 24 (3): 647-655.
CAS
PubMed
Google Scholar
Walters DK, Steinmann P, Langsam B, Schmutz S, Born W, Fuchs B: Identification of potential chemoresistance genes in osteosarcoma. Anticancer Research. 2008, 28 (2A): 673-680.
CAS
PubMed
Google Scholar
Selvarajah GT, Kirpensteijn J, Wolferen MEv, Rao NA, Fieten H, Mol JA: Gene expression profiling of canine osteosarcoma reveals genes associated with short and long survival times. Molecular Cancer. 2009, 8: 72-90. 10.1186/1476-4598-8-72.
Article
PubMed
PubMed Central
Google Scholar