Qian KC, Wang L, Hickey ER, Studts J, Barringer K, Peng C, Kronkaitis A, Li J, White A, Mische S, Farmer B: Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase. J Biol Chem. 2005, 280 (7): 6130-6137. 10.1074/jbc.M409123200.
Article
CAS
PubMed
Google Scholar
Mochizuki T, Kitanaka C, Noguchi K, Muramatsu T, Asai A, Kuchino Y: Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway. J Biol Chem. 1999, 274 (26): 18659-18666. 10.1074/jbc.274.26.18659.
Article
CAS
PubMed
Google Scholar
Wang Z, Bhattacharya N, Mixter PF, Wei W, Sedivy J, Magnuson NS: Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase. Biochim Biophys Acta. 2002, 1593 (1): 45-55. 10.1016/S0167-4889(02)00347-6.
Article
CAS
PubMed
Google Scholar
Bachmann M, Hennemann H, Xing PX, Hoffmann I, Moroy T: The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint. J Biol Chem. 2004, 279 (46): 48319-48328. 10.1074/jbc.M404440200.
Article
CAS
PubMed
Google Scholar
Morishita D, Katayama R, Sekimizu K, Tsuruo T, Fujita N: Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. Cancer Res. 2008, 68 (13): 5076-5085. 10.1158/0008-5472.CAN-08-0634.
Article
CAS
PubMed
Google Scholar
Bhattacharya N, Wang Z, Davitt C, McKenzie IF, Xing PX, Magnuson NS: Pim-1 associates with protein complexes necessary for mitosis. Chromosoma. 2002, 111 (2): 80-95. 10.1007/s00412-002-0192-6.
Article
CAS
PubMed
Google Scholar
Aho TL, Sandholm J, Peltola KJ, Mankonen HP, Lilly M, Koskinen PJ: Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site. FEBS Lett. 2004, 571 (1-3): 43-49. 10.1016/j.febslet.2004.06.050.
Article
CAS
PubMed
Google Scholar
Gu JJ, Wang Z, Reeves R, Magnuson NS: PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis. Oncogene. 2009, 28: 4261-4271. 10.1038/onc.2009.276.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shah N, Pang B, Yeoh KG, Thorn S, Chen CS, Lilly MB, Salto-Tellez M: Potential roles for the PIM1 kinase in human cancer - a molecular and therapeutic appraisal. Eur J Cancer. 2008, 44 (15): 2144-2151. 10.1016/j.ejca.2008.06.044.
Article
CAS
PubMed
Google Scholar
Akasaka H, Akasaka T, Kurata M, Ueda C, Shimizu A, Uchiyama T, Ohno H: Molecular anatomy of BCL6 translocations revealed by long-distance polymerase chain reaction-based assays. Cancer Res. 2000, 60 (9): 2335-2341.
CAS
PubMed
Google Scholar
Sivertsen EA, Galteland E, Mu D, Holte H, Meza-Zepeda L, Myklebost O, Patzke S, Smeland EB, Stokke T: Gain of chromosome 6p is an infrequent cause of increased PIM1 expression in B-cell non-Hodgkin's lymphomas. Leukemia. 2006, 20 (3): 539-542. 10.1038/sj.leu.2404094.
Article
CAS
PubMed
Google Scholar
Pasqualucci L, Neumeister P, Goossens T, Nanjangud G, Chaganti RS, Kuppers R, Dalla-Favera R: Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature. 2001, 412 (6844): 341-346. 10.1038/35085588.
Article
CAS
PubMed
Google Scholar
Gaidano G, Pasqualucci L, Capello D, Berra E, Deambrogi C, Rossi D, Maria Larocca L, Gloghini A, Carbone A, Dalla-Favera R: Aberrant somatic hypermutation in multiple subtypes of AIDS-associated non-Hodgkin lymphoma. Blood. 2003, 102 (5): 1833-1841. 10.1182/blood-2002-11-3606.
Article
CAS
PubMed
Google Scholar
Libra M, Capello D, Gloghini A, Laura P, Berra E, Cerri M, Gasparotto D, Franca S, De Re V, Gaidano G, Carbone A: Analysis of aberrant somatic hypermutation (SHM) in non-Hodgkin's lymphomas of patients with chronic HCV infection. J Pathol. 2005, 206 (1): 87-91. 10.1002/path.1754.
Article
CAS
PubMed
Google Scholar
Montesinos-Rongen M, Van Roost D, Schaller C, Wiestler OD, Deckert M: Primary diffuse large B-cell lymphomas of the central nervous system are targeted by aberrant somatic hypermutation. Blood. 2004, 103 (5): 1869-1875. 10.1182/blood-2003-05-1465.
Article
CAS
PubMed
Google Scholar
van Lohuizen M, Verbeek S, Krimpenfort P, Domen J, Saris C, Radaszkiewicz T, Berns A: Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors. Cell. 1989, 56 (4): 673-682. 10.1016/0092-8674(89)90589-8.
Article
CAS
PubMed
Google Scholar
Breuer M, Slebos R, Verbeek S, van Lohuizen M, Wientjens E, Berns A: Very high frequency of lymphoma induction by a chemical carcinogen in pim-1 transgenic mice. Nature. 1989, 340 (6228): 61-63. 10.1038/340061a0.
Article
CAS
PubMed
Google Scholar
Moroy T, Verbeek S, Ma A, Achacoso P, Berns A, Alt F: E mu N- and E mu L-myc cooperate with E mu pim-1 to generate lymphoid tumors at high frequency in double-transgenic mice. Oncogene. 1991, 6 (11): 1941-1948.
CAS
PubMed
Google Scholar
Dhanasekaran SM, Barrette TR, Ghosh D, Shah R, Varambally S, Kurachi K, Pienta KJ, Rubin MA, Chinnaiyan AM: Delineation of prognostic biomarkers in prostate cancer. Nature. 2001, 412 (6849): 822-826. 10.1038/35090585.
Article
CAS
PubMed
Google Scholar
Ellwood-Yen K, Graeber TG, Wongvipat J, Iruela-Arispe ML, Zhang J, Matusik R, Thomas GV, Sawyers CL: Myc-driven murine prostate cancer shares molecular features with human prostate tumors. Cancer Cell. 2003, 4 (3): 223-238. 10.1016/S1535-6108(03)00197-1.
Article
CAS
PubMed
Google Scholar
Chen WW, Chan DC, Donald C, Lilly MB, Kraft AS: Pim family kinases enhance tumor growth of prostate cancer cells. Mol Cancer Res. 2005, 3 (8): 443-451. 10.1158/1541-7786.MCR-05-0007.
Article
CAS
PubMed
Google Scholar
Roh M, Song C, Kim J, Abdulkadir SA: Chromosomal instability induced by Pim-1 is passage-dependent and associated with dysregulation of cyclin B1. J Biol Chem. 2005, 280 (49): 40568-40577. 10.1074/jbc.M509369200.
Article
CAS
PubMed
Google Scholar
Kim J, Eltoum IE, Roh M, Wang J, Abdulkadir SA: Interactions between cells with distinct mutations in c-MYC and Pten in prostate cancer. PLoS Genet. 2009, 5 (7): e1000542-10.1371/journal.pgen.1000542.
Article
PubMed
PubMed Central
Google Scholar
Roh M, Gary B, Song C, Said-Al-Naief N, Tousson A, Kraft A, Eltoum IE, Abdulkadir SA: Overexpression of the oncogenic kinase Pim-1 leads to genomic instability. Cancer Res. 2003, 63 (23): 8079-8084.
CAS
PubMed
Google Scholar
Roh M, Franco OE, Hayward SW, van der Meer R, Abdulkadir SA: A role for polyploidy in the tumorigenicity of Pim-1-expressing human prostate and mammary epithelial cells. PLoS One. 2008, 3 (7): e2572-10.1371/journal.pone.0002572.
Article
PubMed
PubMed Central
Google Scholar
Carlsson G, Gullberg B, Hafstrom L: Estimation of liver tumor volume using different formulas - an experimental study in rats. J Cancer Res Clin Oncol. 1983, 105 (1): 20-23. 10.1007/BF00391826.
Article
CAS
PubMed
Google Scholar
Cameron IL, Ord VA: Parenteral level of glucose intake on glucose homeostasis, tumor growth, gluconeogenesis, and body composition in normal and tumor-bearing rats. Cancer Res. 1983, 43 (11): 5228-5234.
CAS
PubMed
Google Scholar
Abdulkadir SA, Qu Z, Garabedian E, Song SK, Peters TJ, Svaren J, Carbone JM, Naughton CK, Catalona WJ, Ackerman JJ, Gordon JI, Humphrey PA, Milbrandt J: Impaired prostate tumorigenesis in Egr1-deficient mice. Nat Med. 2001, 7 (1): 101-107. 10.1038/83231.
Article
CAS
PubMed
Google Scholar
Bello D, Webber MM, Kleinman HK, Wartinger DD, Rhim JS: Androgen responsive adult human prostatic epithelial cell lines immortalized by human papillomavirus 18. Carcinogenesis. 1997, 18 (6): 1215-1223. 10.1093/carcin/18.6.1215.
Article
CAS
PubMed
Google Scholar
Horoszewicz JS, Leong SS, Chu TM, Wajsman ZL, Friedman M, Papsidero L, Kim U, Chai LS, Kakati S, Arya SK, Sandberg AA: The LNCaP cell line--a new model for studies on human prostatic carcinoma. Prog Clin Biol Res. 1980, 37: 115-132.
CAS
PubMed
Google Scholar
Horoszewicz JS, Leong SS, Kawinski E, Karr JP, Rosenthal H, Chu TM, Mirand EA, Murphy GP: LNCaP model of human prostatic carcinoma. Cancer Res. 1983, 43 (4): 1809-1818.
CAS
PubMed
Google Scholar
Mickey DD, Stone KR, Wunderli H, Mickey GH, Vollmer RT, Paulson DF: Heterotransplantation of a human prostatic adenocarcinoma cell line in nude mice. Cancer Res. 1977, 37 (11): 4049-4058.
CAS
PubMed
Google Scholar
Stone KR, Mickey DD, Wunderli H, Mickey GH, Paulson DF: Isolation of a human prostate carcinoma cell line (DU 145). Int J Cancer. 1978, 21 (3): 274-281. 10.1002/ijc.2910210305.
Article
CAS
PubMed
Google Scholar
Mickey DD, Stone KR, Wunderli H, Mickey GH, Paulson DF: Characterization of a human prostate adenocarcinoma cell line (DU 145) as a monolayer culture and as a solid tumor in athymic mice. Prog Clin Biol Res. 1980, 37: 67-84.
CAS
PubMed
Google Scholar
Thompson J, Peltola KJ, Koskinen PJ, Janne OA, Palvimo JJ: Attenuation of androgen receptor-dependent transcription by the serine/threonine kinase Pim-1. Lab Invest. 2003, 83 (9): 1301-1309. 10.1097/01.LAB.0000087585.03162.A3.
Article
CAS
PubMed
Google Scholar
Kim O, Jiang T, Xie Y, Guo Z, Chen H, Qiu Y: Synergism of cytoplasmic kinases in IL6-induced ligand-independent activation of androgen receptor in prostate cancer cells. Oncogene. 2004, 23 (10): 1838-1844. 10.1038/sj.onc.1207304.
Article
CAS
PubMed
Google Scholar
Zhang Y, Wang Z, Li X, Magnuson NS: Pim kinase-dependent inhibition of c-Myc degradation. Oncogene. 2008, 27 (35): 4809-4819. 10.1038/onc.2008.123.
Article
CAS
PubMed
Google Scholar
Zippo A, De Robertis A, Serafini R, Oliviero S: PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation. Nat Cell Biol. 2007, 9 (8): 932-944. 10.1038/ncb1618.
Article
CAS
PubMed
Google Scholar
Yin X, Giap C, Lazo JS, Prochownik EV: Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene. 2003, 22 (40): 6151-6159. 10.1038/sj.onc.1206641.
Article
CAS
PubMed
Google Scholar
Huang MJ, Cheng YC, Liu CR, Lin S, Liu HE: A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia. Exp Hematol. 2006, 34 (11): 1480-1489. 10.1016/j.exphem.2006.06.019.
Article
CAS
PubMed
Google Scholar
Lin CP, Liu JD, Chow JM, Liu CR, Liu HE: Small-molecule c-Myc inhibitor, 10058-F4, inhibits proliferation, downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells. Anticancer Drugs. 2007, 18 (2): 161-170. 10.1097/CAD.0b013e3280109424.
Article
CAS
PubMed
Google Scholar
Valdman A, Fang X, Pang ST, Ekman P, Egevad L: Pim-1 expression in prostatic intraepithelial neoplasia and human prostate cancer. Prostate. 2004, 60 (4): 367-371. 10.1002/pros.20064.
Article
CAS
PubMed
Google Scholar
Cibull TL, Jones TD, Li L, Eble JN, Ann Baldridge L, Malott SR, Luo Y, Cheng L: Overexpression of Pim-1 during progression of prostatic adenocarcinoma. J Clin Pathol. 2006, 59 (3): 285-288. 10.1136/jcp.2005.027672.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang J, Kim J, Roh M, Franco OE, Hayward SW, Wills ML, Abdulkadir SA: Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma. Oncogene. 2010, 29 (17): 2477-2487. 10.1038/onc.2010.10.
Article
CAS
PubMed
PubMed Central
Google Scholar
Guo J, Parise RA, Joseph E, Egorin MJ, Lazo JS, Prochownik EV, Eiseman JL: Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice. Cancer Chemother Pharmacol. 2009, 63 (4): 615-625. 10.1007/s00280-008-0774-y.
Article
CAS
PubMed
Google Scholar
Wang H, Hammoudeh DI, Follis AV, Reese BE, Lazo JS, Metallo SJ, Prochownik EV: Improved low molecular weight Myc-Max inhibitors. Mol Cancer Ther. 2007, 6 (9): 2399-2408. 10.1158/1535-7163.MCT-07-0005.
Article
CAS
PubMed
Google Scholar