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  1. Our previous study reported that recombinant human epidermal growth factor (rhEGF)-triggered EGFR internalization promoted radioresistance. Here, we aimed to evaluate the effect of rhEGF on the skin protection...

    Authors: Shuai Liu, Yun-Long Wang, Shu-Ting Shi, Guang-Dong Zeng, Yi-Wen Song, Xiao-Dong Zhang, Jian Zheng, Xin-Juan Fan and Yan-Ping Liu
    Citation: BMC Cancer 2022 22:1140
  2. Triple negative breast cancer (TNBC) is clinically aggressive breast cancer with a poor prognosis. Approximately 20% of TNBC has been found to express programmed death ligand 1 (PD-L1), making it a potential t...

    Authors: K. Sharmni Vishnu, Thin Thin Win, Saint Nway Aye and Arun Kumar Basavaraj
    Citation: BMC Cancer 2022 22:1139
  3. Radical nephrectomy (RN) is the standard treatment for localized renal cell carcinoma. The decrease in nephrons from RN could lead to postoperative chronic kidney disease (CKD). In this study, we aim to invest...

    Authors: Shuai Wang, Zhenghong Liu, Dahong Zhang, Fei Xiang and Wei Zheng
    Citation: BMC Cancer 2022 22:1138
  4. Dermatofibrosarcoma protuberans (DFSP) is a rare, low to intermediate-grade sarcoma, which needs imaging examination. Small series of ultrasound findings in DFSP have been published; however, the usefulness of...

    Authors: Xia Gong, Jia Li, Angang Ding, Jun Chen, Xiaofeng Tao, Ping Xiong, Yamin Rao, Yang Liu and Qilin Sun
    Citation: BMC Cancer 2022 22:1137
  5. Immune checkpoint inhibitors (ICIs) has shown remarkable benefit in the treatment of a range of cancer types, although it may initiate immune related adverse events (irAEs) in patients. Some studies have shown...

    Authors: Xiaoyun Zhang, Shuo Xu, Jiaqi Wang, Yalei Lv, Na Wang, Ruixue Lai, Ziyue Sha, Qun Zhao and Zhanjun Guo
    Citation: BMC Cancer 2022 22:1136
  6. Small-cell lung cancer (SCLC) accounts for 12–15% of lung cancers and has a limited prognosis, with approximately one-third of SCLC patients having a poor performance status (PS). Patients with extensive-stage...

    Authors: Tetsuhiko Asao, Satoshi Watanabe, Takahiro Tanaka, Satoshi Morita and Kunihiko Kobayashi
    Citation: BMC Cancer 2022 22:1135
  7. The distribution of tissue infiltrating lymphocytes has been shown to affect the prognosis of patients with pancreatic cancer in some previous studies. However, the role of peripheral lymphocytes in pancreatic...

    Authors: Katsuhito Teramatsu, Takamasa Oono, Koki Oyama, Nao Fujimori, Masatoshi Murakami, Sho Yasumori, Akihisa Ohno, Kazuhide Matsumoto, Ayumu Takeno, Kohei Nakata, Masafumi Nakamura and Yoshihiro Ogawa
    Citation: BMC Cancer 2022 22:1134
  8. The COVID-19 pandemic greatly impacted primary care and cancer care. We studied how primary care utilization in Ontario, Canada changed for patients who were newly diagnosed with cancer just prior to the COVID...

    Authors: Ying Ling, Matthew C. Cheung, Kelvin K.W. Chan, Aisha Lofters, Colleen Fox, Aditi Patrikar, Ning Liu and Simron Singh
    Citation: BMC Cancer 2022 22:1133
  9. N7-Methylguanosine (m7G) and long non-coding RNAs (lncRNAs) have been widely studied in cancer and have been found to be useful for assessing tumor progression. However, the role of m7G-related lncRNAs in lung...

    Authors: Junfan Pan, Zhidong Huang, Hancui Lin, Wenfang Cheng, Jinhuo Lai and Jiancheng Li
    Citation: BMC Cancer 2022 22:1132
  10. Cuproptosis, a new form of programmed cell death, has been recently reported to be closely related to tumor progression. However, the significance of cuproptosis-related genes (CRGs) in papillary thyroid carci...

    Authors: Lidong Wang, Baiyu Yao, Jiapeng Yang, Zhong Tian and Jingni He
    Citation: BMC Cancer 2022 22:1131
  11. The aim of this study was to estimate occupational risk variation in the incidence of nasopharyngeal cancer (NPC) in a large population-based cohort of the Nordic Occupational Cancer (NOCCA) study.

    Authors: Timo Carpén, Evelina Gille, Lalle Hammarstedt-Nordenvall, Johnni Hansen, Sanna Heikkinen, Elsebeth Lynge, Jenny Selander, Ingrid Sivesind Mehlum, Jóhanna Eyrún Torfadottir, Antti Mäkitie and Eero Pukkala
    Citation: BMC Cancer 2022 22:1130
  12. To analyze the clinical outcomes of patients with regional persistent/recurrent nasopharyngeal carcinoma (NPC) who received neck dissection, and to evaluate the clinical benefit of postoperative adjuvant thera...

    Authors: Sai-Lan Liu, Xiao-Yun Li, Xue-Song Sun, Jing-Yun Peng, Chao Lin, Jin-Jie Yan, Qiu-Yan Chen, Lin-Quan Tang, Shan-Shan Guo, Ling Guo, Li-Ting Liu and Hai-Qiang Mai
    Citation: BMC Cancer 2022 22:1129
  13. Nutritional status and inflammation are closely associated with poor outcome in malignant tumors. However, the prognostic impact of postoperative in these variables on breast cancer (BC) remains inconclusive. ...

    Authors: Tai Xu, Si-Ming Zhang, He-Ming Wu, Xiao-Min Wen, Dong-Qin Qiu, Yu-Yang Yang, Li-Zhen Wang, Wen-Biao Zhu, Li-Shan He and Jian-Juan Li
    Citation: BMC Cancer 2022 22:1128
  14. Acute myeloid leukemia (AML) is the main type of adult leukemia, and 60-day mortality is a vital clinical problem that doctors have to face at the begin with treatment. Studies on the association between serum...

    Authors: Zuomiao Xiao, Haibo Li, Dejun Xiao, Yulan Liu, Xianchun Chen, Shi Luo and Yanhong Ji
    Citation: BMC Cancer 2022 22:1127
  15. Although determining the recurrence of cutaneous squamous cell carcinoma (cSCC) is important, currently suggested systems and single biomarkers have limited power for predicting recurrence.

    Authors: Yeongjoo Oh, Zhenlong Zheng, Ki-Yeol Kim, Xiangshu Xu, Meiling Pei, Byungho Oh, Sang Kyem Kim, Kee Yang Chung and Mi Ryung Roh
    Citation: BMC Cancer 2022 22:1126
  16. Bilateral breast cancer (BBC), as well as ovarian cancer, are significantly associated with germline deleterious variants in BRCA1/2, while BRCA1/2 germline deleterious variants carriers can exquisitely benefit f...

    Authors: Yan Li, Lili Chen, Jinxing Lv, Xiaobin Chen, Bangwei Zeng, Minyan Chen, Wenhui Guo, Yuxiang Lin, Liuwen Yu, Jialin Hou, Jing Li, Peng Zhou, Wenzhe Zhang, Shengmei Li, Xuan Jin, Weifeng Cai…
    Citation: BMC Cancer 2022 22:1125
  17. Osteosarcoma (OS) mainly happens in children and youths. Surgery, radiotherapy and chemotherapy are the common therapies for osteosarcoma treatment but all their anti-tumor effects are limited. In recent years...

    Authors: Qian Zhang, Zhiqiang Zhang, Guodi Liu, Dehua Li, Zhangjie Gu, Linsong Zhang, Yingjiao Pan, Xingbing Cui, Lu Wang, Guoping Liu, Xiaoli Tian and Ziming Zhang
    Citation: BMC Cancer 2022 22:1124
  18. Breast cancer incidence is rising globally, while mortality rates show a geographical heterogenous pattern. Early detection and treatment have been proven to have a profound impact on breast cancer prognosis. ...

    Authors: Mikaela Roginski, Dimitra Sifaki-Pistolla, Andreas Stomby, Georgia Velivasaki, Tomas Faresjö, Christos Lionis and Åshild Faresjö
    Citation: BMC Cancer 2022 22:1123
  19. IQ motif-containing GTPase-activating proteins (IQGAPs) are a group of scaffold proteins which have been identified to be involved in tumor initiation and progression in diverse types of cancer. Clinical studi...

    Authors: Qingqing Dai, Fei Song, Xincheng Li, Fan Huang and Hongchuan Zhao
    Citation: BMC Cancer 2022 22:1121
  20. Relationship between cancer cell glycolysis and the landscape of tumor immune microenvironment in human cancers was investigated.

    Authors: Sehui Kim, Jaemoon Koh, Seung Geun Song, Jeemin Yim, Miso Kim, Bhumsuk Keam, Young Tae Kim, Jihun Kim, Doo Hyun Chung and Yoon Kyung Jeon
    Citation: BMC Cancer 2022 22:1120
  21. Colorectal cancer remains the second leading cause of cancer death in North America. Fluorouracil and oxaliplatin based adjuvant chemotherapy for resected colon cancer (CC) reduces cancer recurrence, but also ...

    Authors: Daniel Breadner, Jonathan M. Loree, Winson Y. Cheung, Meghan Gipson, Suganija Lakkunarajah, Karen E. Mulder, Jennifer L. Spartlin, Shiying Kong, Philip Q. Ding, Sharlene Gill and Stephen A. Welch
    Citation: BMC Cancer 2022 22:1119
  22. Solid pulmonary nodules are different from subsolid nodules and the diagnosis is much more challenging. We intended to evaluate the diagnostic and prognostic value of radiomics and deep learning technologies f...

    Authors: Rui Zhang, Ying Wei, Feng Shi, Jing Ren, Qing Zhou, Weimin Li and Bojiang Chen
    Citation: BMC Cancer 2022 22:1118
  23. The aim of this prospective study was to investigate the prognostic value of metabolic tumor volume (MTV) and apparent diffusion coefficient (ADC) from baseline FDG PET/MRI compared to established clinical ris...

    Authors: Trine Husby, Håkon Johansen, Trond Velde Bogsrud, Kari Vekseth Hustad, Birte Veslemøy Evensen, Ronald Boellaard, Guro F. Giskeødegård, Unn-Merete Fagerli and Live Eikenes
    Citation: BMC Cancer 2022 22:1117
  24. The linkage between IDO2 expression and cancer progression is still unclear, particularly in medullary thyroid carcinoma (MTC). Our purpose is to unveil the potential correlations between IDO2 status, clinical...

    Authors: Pengfei Gu, Bin Ling, Weike Ma, Jinming Zhang, Wei Zhang, Yu Zeng, Yu Liu, Jiadong Chi, Xianhui Ruan, Xiangqian Zheng, Songfeng Wei and Ming Gao
    Citation: BMC Cancer 2022 22:1116
  25. Women with breast cancer are at risk for the development of sarcopenia and occurrence of fractures. The initial and periodic screening of these conditions can prevent the risks of disability, poor quality of l...

    Authors: Rayne de Almeida Marques Bernabé, Mariana de Souza Vieira, Vanusa Felício de Souza, Luana Gomes Fontana, Ben-Hur Albergaria, José Luiz Marques-Rocha and Valdete Regina Guandalini
    Citation: BMC Cancer 2022 22:1115
  26. This study aimed to report the prevalence of HER2-neu in newly diagnosed early or metastatic gastric cancer (GC) patients, to determine the percentage of patients achieving various IHC scores correlating with ...

    Authors: Joseph Kattan, Fady el Karak, Fadi Farhat, Dany Abi Gerges, Walid Mokaddem, Georges Chahine, Saad Khairallah, Najla Fakhruddin, Jawad Makarem and Fadi Nasr
    Citation: BMC Cancer 2022 22:1114
  27. Overall survival of advanced colorectal cancer (CRC) patients remains poor, and gene expression analysis could potentially complement detection of clinically relevant mutations to personalize CRC treatments.

    Authors: Maxim Sorokin, Marianna Zolotovskaia, Daniil Nikitin, Maria Suntsova, Elena Poddubskaya, Alexander Glusker, Andrew Garazha, Alexey Moisseev, Xinmin Li, Marina Sekacheva, David Naskhletashvili, Alexander Seryakov, Ye Wang and Anton Buzdin
    Citation: BMC Cancer 2022 22:1113
  28. Worldwide, esophageal cancer (EC) is a common cancer in term of incidence and mortality and is the 4th common cancer in Afghanistan. Current study aimed to evaluate the profile of risk factors for EC among pat...

    Authors: Ramin Saadaat, Jamshid Abdul-Ghafar, Ahmed Nasir Hanifi, Saifullah Khalid, Abdul Latif Khairy, Abdul Sami Ibrahimkhil, Haider Ali Malakzai, Esmatullah Esmat, Mujtaba Haidari, Nasrin Hussaini, Najla Nasir, Sarah Noor and Ahmed Maseh Haidary
    Citation: BMC Cancer 2022 22:1112
  29. This study investigated site-specific differences in clinical factors for recurrence in patients who were newly diagnosed and treated for endometrial cancer. A model for predicting recurrence sites was generated.

    Authors: Wonkyo Shin, Seong J. Yang, Sang-Yoon Park, Sokbom Kang, Dong Ock Lee, Myong Cheol Lim and Sang-Soo Seo
    Citation: BMC Cancer 2022 22:1111
  30. Lung cancer is currently the most frequent cancer in Jiangsu Province, China, and the features of cancer distribution have changed continuously in the last decade. The aim of this study was to analyse the tren...

    Authors: Yuchen Jiang, Renqiang Han, Jian Su, Xikang Fan, Hao Yu, Ran Tao and Jinyi Zhou
    Citation: BMC Cancer 2022 22:1110
  31. Most patients with cancer and their caregivers desire honest, clear prognostic communication, yet oncologists often disclose prognosis inconsistently. Prognostic communication becomes even more challenging whe...

    Authors: Amy S. Porter, Cameka Woods, Melanie Stall, Srilakshmi Velrajan, Justin N. Baker, Jennifer W. Mack and Erica C. Kaye
    Citation: BMC Cancer 2022 22:1109
  32. The clinical significance of tertiary lymphoid structures (TLSs) is not well-documented in early oral tongue squamous cell carcinoma (OTSCC).

    Authors: Alhadi Almangush, Ibrahim O. Bello, Amr Elseragy, Jaana Hagström, Caj Haglund, Luiz Paulo Kowalski, Pentti Nieminen, Ricardo D. Coletta, Antti A. Mäkitie, Tuula Salo and Ilmo Leivo
    Citation: BMC Cancer 2022 22:1108
  33. AZD0156 is an oral inhibitor of ATM, a serine threonine kinase that plays a key role in DNA damage response (DDR) associated with double-strand breaks. Topoisomerase-I inhibitor irinotecan is used clinically t...

    Authors: S. Lindsey Davis, Sarah J. Hartman, Stacey M. Bagby, Marina Schlaepfer, Betelehem W. Yacob, Tonia Tse, Dennis M. Simmons, Jennifer R. Diamond, Christopher H. Lieu, Alexis D. Leal, Elaine B. Cadogan, Gareth D. Hughes, Stephen T. Durant, Wells A. Messersmith and Todd M. Pitts
    Citation: BMC Cancer 2022 22:1107
  34. Hepatocellular carcinoma (HCC) is a global health problem with regional differences in epidemiological statistics. Co-assembling the drug nanoparticles and targeting moieties could improve the therapeutic deli...

    Authors: Ahmed A. Abd-Rabou, Hanaa H. Ahmed and Mohamed S. Kishta
    Citation: BMC Cancer 2022 22:1106
  35. Endoscopic screening is the widely accepted screening strategy for esophageal squmaous cell carcinoma (ESCC). However, massive endoscopic screening is expensive and not cost-efficient, and novel pre-endoscopy ...

    Authors: Yadong Feng, Bin Wang, Liang Pan, Bin Yao, Bin Deng, Yan Liang, Yongzhen Sun, Juncai Zang, Xinyi Xu, Jie Song, Mengjie Li, Guangpeng Xu, Kai Zhao, Cui-E. Cheng and Ruihua Shi
    Citation: BMC Cancer 2022 22:1105
  36. An over-expression of the epidermal growth factor receptor (EGFR) has been observed in colorectal cancer and is associated with aggressive disease and poor prognosis. SCT200 is a newly developed recombinant, f...

    Authors: Wen Zhang, Xiaohong Han, Lin Yang, Yuanyuan Song, Liangzhi Xie, Wenlin Gai, Yan Wang and Yuankai Shi
    Citation: BMC Cancer 2022 22:1104
  37. The specific differentiation potential, unlimited proliferation, and self-renewal capacity of cancer stem cells (CSCs) are closely related to the occurrence, recurrence, and drug resistance of hepatocellular c...

    Authors: Genhao Zhang, Kai Zhang, Yanteng Zhao, Qiankun Yang and Xianping Lv
    Citation: BMC Cancer 2022 22:1103
  38. Postoperative chemoradiotherapy (CRT) is a standard therapy for patients with high-risk factors for head and neck squamous cell carcinoma, including positive margin and extra-nodal extension (ENE). However, th...

    Authors: Ari Nishimura, Tomoya Yokota, Satoshi Hamauchi, Yusuke Onozawa, Akifumi Notsu, Fuyuki Sato, Takeshi Kawakami, Hirofumi Ogawa, Tsuyoshi Onoe and Takashi Mukaigawa
    Citation: BMC Cancer 2022 22:1101
  39. Increasing evidence has convincingly shown that abnormal pre-mRNA splicing is implicated in the development of most human malignancies. Serine/arginine-rich protein kinase 1 (SRPK1), a key splicing regulator, ...

    Authors: Cuiying He, Beichen Liu, Huan-You Wang, Lili Wu, Guimin Zhao, Chen Huang, Yueping Liu, Baoen Shan and Lihong Liu
    Citation: BMC Cancer 2022 22:1100
  40. IMpassion130 led to the approval of atezolizumab plus nab-paclitaxel as first-line treatment for patients with unresectable locally advanced or metastatic triple-negative, PD-L1 immune-cell positive breast can...

    Authors: Christine Deutschmann, Rupert Bartsch, Christian F Singer, Daphne Gschwantler-Kaulich, Michael Seifert, Carmen Leser, Maximilian Marhold, Zsuzsanna Bago-Horvath and Georg Pfeiler
    Citation: BMC Cancer 2022 22:1099
  41. Increasing evidence shows that liver-specific long non-coding RNAs (lncRNAs) play important roles in the development of hepatocellular carcinoma (HCC). We identified a novel liver-specific lncRNA, FAM99A, and ...

    Authors: Meile Mo, Xiaoyun Ma, Yihuan Luo, Chao Tan, Bihu Liu, Peng Tang, Qian Liao, Shun Liu, Hongping Yu, Dongping Huang, Xiaoyun Zeng and Xiaoqiang Qiu
    Citation: BMC Cancer 2022 22:1098
  42. Existing research on the perspectives of patients with cancer and health care professionals indicates that patient decision making on cancer clinical trial participation is a complex process and may be poorly ...

    Authors: Line Hillersdal, Zandra Engelbak Nielsen, Ane Taudorf Nørmark, Ann Knoop and Karin Piil
    Citation: BMC Cancer 2022 22:1097
  43. Cervical cancer (CC) is the number one leading cause of death among women in Malawi. However, it is generally viewed as preventable and treatable if diagnosed in an early stage. Despite the burden, Malawi regi...

    Authors: Felistas Mpachika-Mfipa, Lucy Ida Kululanga, Abigail Kazembe and Dumisani Mfipa
    Citation: BMC Cancer 2022 22:1096
  44. Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, with overall survival remaining poor despite ongoing efforts to explore new treatment paradigms. Given these outcomes, efforts hav...

    Authors: Matthew Gallitto, Michelle Savacool, Albert Lee, Tony J. C. Wang and Michael B. Sisti
    Citation: BMC Cancer 2022 22:1095
  45. As a human tumor disease, head and neck squamous cell carcinoma (HNSCC) is associated with a high mortality rate worldwide. Nicotinic acetylcholine receptors (nAChRs) are transmembrane receptor proteins and ex...

    Authors: Yujie Shen, Qiang Huang, Mengyou Ji, Chi-Yao Hsueh and Liang Zhou
    Citation: BMC Cancer 2022 22:1093
  46. Antibodies and derivative drugs targeting immune checkpoints have been approved for the treatment of several malignancies, but there are fewer responses in patients with pancreatic cancer. Here, we designed a ...

    Authors: Shuai Hao, Shuyi Xu, Liangzhu Li, Yaxian Li, Meiqi Zhao, Junsheng Chen, Shunying Zhu, Yueqing Xie, Hua Jiang, Jianwei Zhu and Mingyuan Wu
    Citation: BMC Cancer 2022 22:1092

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