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  1. Cancer stem cells (CSCs) play an important role in the development and recurrence of malignant tumors including glioma. Notch signaling, an evolutionarily conserved pathway mediating direct cell-cell interacti...

    Authors: Yi-Yang Hu, Min-Hua Zheng, Gang Cheng, Liang Li, Liang Liang, Fang Gao, Ya-Ning Wei, Luo-An Fu and Hua Han
    Citation: BMC Cancer 2011 11:82
  2. The molecular mechanisms of CC (cholangiocarcinoma) oncogenesis and progression are poorly understood. This study aimed to determine the genome-wide expression of genes related to CC oncogenesis and sarcomatou...

    Authors: Min-A Seol, In-Sun Chu, Mi-Jin Lee, Goung-Ran Yu, Xiang-Dan Cui, Baik-Hwan Cho, Eun-Kyung Ahn, Sun-Hee Leem, In-Hee Kim and Dae-Ghon Kim
    Citation: BMC Cancer 2011 11:78
  3. One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP requires the participation of a number of conserved factors such as the THO complex. THO in...

    Authors: María S Domínguez-Sánchez, Carmen Sáez, Miguel A Japón, Andrés Aguilera and Rosa Luna
    Citation: BMC Cancer 2011 11:77
  4. Leiomyosarcoma occurring as a primary cardiac tumor has been known as an extremely rare condition. Previous studies of leiomyosarcoma with rhabdomyoblastic differentiation have conducted to those arisen from a...

    Authors: Yoichiro Okubo, Kazutoshi Shibuya, Atsushi Namiki, Kazuhisa Takamura, Noriaki Kameda, Tetsuo Nemoto, Aki Mitsuda, Megumi Wakayama, Minoru Shinozaki, Nobuyuki Hiruta, Kanako Kitahara, Takao Ishiwatari and Junichi Yamazaki
    Citation: BMC Cancer 2011 11:76
  5. To evaluate whether weekly schedules of docetaxel-based chemotherapy were superior to 3-weekly ones in terms of quality of life in locally advanced or metastatic breast cancer.

    Authors: Francesco Nuzzo, Alessandro Morabito, Adriano Gravina, Francesca Di Rella, Gabriella Landi, Carmen Pacilio, Vincenzo Labonia, Emanuela Rossi, Ermelinda De Maio, Maria Carmela Piccirillo, Giuseppe D'Aiuto, Renato Thomas, Massimo Rinaldo, Gerardo Botti, Maurizio Di Bonito, Massimo Di Maio…
    Citation: BMC Cancer 2011 11:75
  6. To study whether and how c-MYC expression determines response to radio- and chemotherapy in childhood medulloblastoma (MB).

    Authors: André O von Bueren, Christoph Oehler, Tarek Shalaby, Katja von Hoff, Martin Pruschy, Burkhardt Seifert, Nicolas U Gerber, Monika Warmuth-Metz, Duncan Stearns, Charles G Eberhart, Rolf D Kortmann, Stefan Rutkowski and Michael A Grotzer
    Citation: BMC Cancer 2011 11:74
  7. Epitheliomesenchymal transition (EMT) is the process where cancer cells attain fibroblastic features and are thus able to invade neighboring tissues. Transcriptional factors zeb1, snai1 and twist regulate EMT.

    Authors: Ylermi Soini, Hanna Tuhkanen, Reijo Sironen, Ismo Virtanen, Vesa Kataja, Päivi Auvinen, Arto Mannermaa and Veli-Matti Kosma
    Citation: BMC Cancer 2011 11:73
  8. The role of surgery in the management of patients with advanced gastrointestinal stromal tumors (GIST) in the era of imatinib mesylate (IM) remains debated. We analyzed the outcome of patients with non metasta...

    Authors: Aurore Blesius, Philippe A Cassier, François Bertucci, Jerome Fayette, Isabelle Ray-Coquard, Binh Bui, Antoine Adenis, Maria Rios, Didier Cupissol, David Pérol, Jean-Yves Blay and Axel Le Cesne
    Citation: BMC Cancer 2011 11:72
  9. Local control in adjuvant/definitive RT of adenoid cystic carcinoma (ACC) is largely dose-dependent leading to the establishment of particle therapy in this indication. However, even modern techniques leave sp...

    Authors: Alexandra D Jensen, Anna Nikoghosyan, Axel Hinke, Jürgen Debus and Marc W Münter
    Citation: BMC Cancer 2011 11:70
  10. Protein secretion by mammary cells results in autocrine and paracrine signaling that defines cell growth, migration and the extracellular environment. Even so, we have a limited understanding of the cellular p...

    Authors: Yi Zhang, Rachel M Gonzalez and Richard C Zangar
    Citation: BMC Cancer 2011 11:69
  11. In principle, the elimination of malignancies by oncolytic virotherapy could proceed by different mechanisms - e.g. tumor cell specific oncolysis, destruction of the tumor vasculature or an anti-tumoral immuno...

    Authors: Stephanie Weibel, Viktoria Raab, Yong A Yu, Andrea Worschech, Ena Wang, Francesco M Marincola and Aladar A Szalay
    Citation: BMC Cancer 2011 11:68
  12. Treatment options for patients with advanced hepatocellular carcinoma (HCC) are often limited. In most cases, they are not amenable to local therapies including surgery or radiofrequency ablation. The multi-ki...

    Authors: Stephanie E Combs, Daniel Habermehl, Tom Ganten, Jan Schmidt, Lutz Edler, Iris Burkholder, Oliver Jäkel, Thomas Haberer and Jürgen Debus
    Citation: BMC Cancer 2011 11:67
  13. Epigenetic mechanisms such as DNA methylation and histone modifications are important regulators of gene expression and are frequently involved in silencing tumor suppressor genes.

    Authors: Helena Carén, Anna Djos, Maria Nethander, Rose-Marie Sjöberg, Per Kogner, Camilla Enström, Staffan Nilsson and Tommy Martinsson
    Citation: BMC Cancer 2011 11:66
  14. Compromised epithelial barriers are found in dysplastic tissue of the gastrointestinal tract. Claudins are transmembrane proteins important for tight junctions. Claudins regulate the paracellular transport and...

    Authors: Jette Bornholdt, Stine Friis, Sine Godiksen, Steen S Poulsen, Eric Santoni-Rugiu, Hanne C Bisgaard, Inger MB Lothe, Tone Ikdahl, Kjell M Tveit, Egil Johnson, Elin H Kure and Lotte K Vogel
    Citation: BMC Cancer 2011 11:65
  15. Although preoperative radiotherapy (RT) is widely used as the initial treatment for locally advanced rectal cancer (RC) in the neoadjuvant setting, factors determining clinical response have not been adequatel...

    Authors: Joji Kitayama, Koji Yasuda, Kazushige Kawai, Eiji Sunami and Hirokazu Nagawa
    Citation: BMC Cancer 2011 11:64
  16. Tumor hypoxia is linked to poor prognosis, but identification and quantification of tissue hypoxia remains a challenge. The hypoxia-specificity of HIF-1α target genes in vivo has been questioned due to the con...

    Authors: Morten Busk, Kasper Toustrup, Brita S Sørensen, Jan Alsner, Michael R Horsman, Steen Jakobsen and Jens Overgaard
    Citation: BMC Cancer 2011 11:63
  17. Treatment of tumors with macromolecular toxins directed to cytoplasmic targets requires selective endocytosis followed by release of intact toxin from the endosomal/lysosomal compartment. The latter step remai...

    Authors: Xiaoqin Yuan, Xinjian Lin, Gerald Manorek and Stephen B Howell
    Citation: BMC Cancer 2011 11:61
  18. The genetics of advanced biliary tract cancers (BTC), which encompass intra- and extra-hepatic cholangiocarcinomas as well as gallbladder carcinomas, are heterogeneous and remain to be fully defined.

    Authors: Vikram Deshpande, Afamefuna Nduaguba, Stephanie M Zimmerman, Sarah M Kehoe, Laura E MacConaill, Gregory Y Lauwers, Cristina Ferrone, Nabeel Bardeesy, Andrew X Zhu and Aram F Hezel
    Citation: BMC Cancer 2011 11:60
  19. Transforming growth factor (TGF)-β plays a dual role during mammary gland development and tumorigenesis and has been shown to stimulate epithelial-mesenchymal transition (EMT) as well as cellular migration. Th...

    Authors: Kelly J Gauger, Kerry L Chenausky, Molly E Murray and Sallie S Schneider
    Citation: BMC Cancer 2011 11:59
  20. Histone modifications in tumorigenesis are increasingly recognized as important epigenetic factors leading to cancer. Increased phosphorylation levels of histone H3 as a result of aurora B and pMSK1 overexpres...

    Authors: Chien-Chih Lee, Yi-Hsiung Lin, Wen-Hsin Chang, Pei-Chin Lin, Yang-Chang Wu and Jan-Gowth Chang
    Citation: BMC Cancer 2011 11:58
  21. This study was performed to investigate the effect of microRNA-203 (miR-203) and ΔNp63 on cell proliferation and the functional connection between miR-203 and ΔNp63 in ESCC.

    Authors: Yang Yuan, Zhi-Yong Zeng, Xiao-Hong Liu, De-Jun Gong, Jing Tao, He-Zhong Cheng and Sheng-Dong Huang
    Citation: BMC Cancer 2011 11:57
  22. Mammary carcinomas have been associated with a high-fat diet, and the rate of breast cancer in overweight post-menopausal women is up to 50% higher than in their normal-weight counterparts. Epidemiological stu...

    Authors: Katja Linher-Melville, Stephanie Zantinge, Toran Sanli, Hertzel Gerstein, Theodoros Tsakiridis and Gurmit Singh
    Citation: BMC Cancer 2011 11:56
  23. To evaluate efficacy and feasibility of chemo-radiotherapy in patients with non-metastatic anal squamous-cell-cancer.

    Authors: Maria G Zampino, Elena Magni, Maria C Leonardi, Luigi Santoro, Elena Petazzi, Cristiana Fodor, Giuseppe Petralia, Cristina Trovato, Franco Nolè and Roberto Orecchia
    Citation: BMC Cancer 2011 11:55
  24. Adeno-associated virus-2 (AAV-2)-mediated gene therapy is quite suitable for local or regional application in head and neck cancer squamous cell carcinoma (HNSCC). However, its low transduction efficiency has ...

    Authors: Minghong Jiang, Zheng Liu, Yang Xiang, Hong Ma, Shilian Liu, Yanxin Liu and Dexian Zheng
    Citation: BMC Cancer 2011 11:54
  25. Infection plays a role in the pathogenesis of many human malignancies. Whether prostate cancer (PCa) - an important health issue in the aging male population in the Western world - belongs to these conditions ...

    Authors: Jan Hrbacek, Michael Urban, Eva Hamsikova, Ruth Tachezy, Vaclav Eis, Marek Brabec and Jiri Heracek
    Citation: BMC Cancer 2011 11:53
  26. The esophageal carcinoma related gene 4 (ECRG4) was initially identified and cloned from human normal esophageal epithelium in our laboratory (GenBank accession no.AF325503). ECRG4 has been described as a nove...

    Authors: Lin-wei Li, Yuan-yuan Li, Xiao-yan Li, Chun-peng Zhang, Yun Zhou and Shih-Hsin Lu
    Citation: BMC Cancer 2011 11:52
  27. CD26 (dipeptidyl peptidase IV, DPPIV) is a 110 kDa surface glycoprotein expressed in most normal tissues, and is a potential novel therapeutic target for selected cancers. Our work evaluates the mechanism invo...

    Authors: Masako Abe, Pamela A Havre, Yasuyo Urasaki, Kei Ohnuma, Chikao Morimoto, Long H Dang and Nam H Dang
    Citation: BMC Cancer 2011 11:51
  28. NET1, a RhoA guanine exchange factor, is up-regulated in gastric cancer (GC) tissue and drives the invasive phenotype of this disease. In this study, we aimed to determine the role of NET1 in GC by monitoring ...

    Authors: Gayle Bennett, Denise Sadlier, Peter P Doran, Padraic MacMathuna and David W Murray
    Citation: BMC Cancer 2011 11:50
  29. Epithelial-mesenchymal transition (EMT) not only confers tumor cells with a distinct advantage for metastatic dissemination, but also it provides those cells with cancer stem cell-like characters for prolifera...

    Authors: Junlin Li and Binhua P Zhou
    Citation: BMC Cancer 2011 11:49
  30. Despite evidence that up to 35% of patients with cancer experience significant distress, access to effective psychosocial care is limited by lack of systematic approaches to assessment, a paucity of psychosoci...

    Authors: Jane Turner, Brian Kelly, David Clarke, Patsy Yates, Sanchia Aranda, Damien Jolley, Suzanne Chambers, Maryanne Hargraves and Lisa McFadyen
    Citation: BMC Cancer 2011 11:48
  31. Epithelial cell adhesion molecule (EpCAM) has been used as surrogate marker for the quantification of circulating tumour cells (CTC). Our aim was to prospectively study the value of a real-time RT-PCR assay fo...

    Authors: Gregory Sergeant, Tania Roskams, Jos van Pelt, François Houtmeyers, Raymond Aerts and Baki Topal
    Citation: BMC Cancer 2011 11:47
  32. Cancer can be a distressing experience for cancer patients and carers, impacting on psychological, social, physical and spiritual functioning. However, health professionals often fail to detect distress in the...

    Authors: Karen L Hughes, Hilary Sargeant and Anna L Hawkes
    Citation: BMC Cancer 2011 11:46
  33. Recently, EpCAM has attracted major interest as a target for antibody- and vaccine-based cancer immunotherapies. In breast cancer, the EpCAM antigen is overexpressed in 30-40% of all cases and this increased e...

    Authors: Johanna M Gostner, Dominic Fong, Oliver A Wrulich, Florian Lehne, Marion Zitt, Martin Hermann, Sylvia Krobitsch, Agnieszka Martowicz, Guenther Gastl and Gilbert Spizzo
    Citation: BMC Cancer 2011 11:45
  34. This trial aims to evaluate the effectiveness of a group cognitive behavioural intervention to alleviate menopausal symptoms (hot flushes and night sweats) in women who have had breast cancer treatment. Hot fl...

    Authors: Eleanor Mann, Melanie Smith, Jennifer Hellier and Myra S Hunter
    Citation: BMC Cancer 2011 11:44
  35. Oncolytic virotherapy for cancer treatment utilizes viruses for selective infection and death of cancer cells without any adverse effect on normal cells. We previously reported that the human respiratory syncy...

    Authors: Ibtissam Echchgadda, Te-Hung Chang, Ahmed Sabbah, Imad Bakri, Yuji Ikeno, Gene B Hubbard, Bandana Chatterjee and Santanu Bose
    Citation: BMC Cancer 2011 11:43
  36. The SRY-related HMG-box family of transcription factors member SOX2 has been mainly studied in embryonic stem cells as well as early foregut and neural development. More recently, SOX2 was shown to participate in...

    Authors: Claudia Lengerke, Tanja Fehm, Ralf Kurth, Hans Neubauer, Veit Scheble, Friederike Müller, Friederike Schneider, Karen Petersen, Diethelm Wallwiener, Lothar Kanz, Falko Fend, Sven Perner, Petra M Bareiss and Annette Staebler
    Citation: BMC Cancer 2011 11:42
  37. The prognosis for patients with advanced FIGO stage III epithelial ovarian cancer remains poor despite the aggressive standard treatment, consisting of maximal cytoreductive surgery and platinum-based chemothe...

    Authors: Nathalie Rochet, Meinhard Kieser, Florian Sterzing, Sonja Krause, Katja Lindel, Wolfgang Harms, Michael H Eichbaum, Andreas Schneeweiss, Christof Sohn and Juergen Debus
    Citation: BMC Cancer 2011 11:41
  38. Pancreatic cancer is the fourth leading cause of tumour death in the western world. However, appropriate tumour models are scarce. Here we present a syngeneic murine pancreatic cancer model using 7 Tesla MRI a...

    Authors: Ivo L Partecke, André Kaeding, Matthias Sendler, Nele Albers, Jens-P Kühn, Sven Speerforck, Sebastian Roese, Florian Seubert, Stephan Diedrich, Sandra Kuehn, Ulrich F Weiss, Julia Mayerle, Markus M Lerch, Stefan Hadlich, Norbert Hosten, Claus-D Heidecke…
    Citation: BMC Cancer 2011 11:40
  39. rhTRAIL is a therapeutic agent, derived from the TRAIL cytokine, which induces apoptosis in cancer cells by activating the membrane death receptors 4 and 5 (DR4 and DR5). Here, we investigated each receptor's ...

    Authors: Caroline MM van Geelen, Bodvael Pennarun, Phuong TK Le, Elisabeth GE de Vries and Steven de Jong
    Citation: BMC Cancer 2011 11:39
  40. FMS-like tyrosine kinase 3 (FLT3) is a commonly mutated protein in a variety of human acute leukemias. Mutations leading to constitutively active FLT3, including internal tandem duplications of the juxtamembra...

    Authors: Steven E Suter, George W Small, Eric L Seiser, Rachael Thomas, Matthew Breen and Kristy L Richards
    Citation: BMC Cancer 2011 11:38
  41. The aim of this study was to assess the treatment results and toxicity profiles of helical tomotherapy (HT) for postoperative high-risk oral cavity cancer.

    Authors: Chen-Hsi Hsieh, Ying-Shiung Kuo, Li-Jen Liao, Kawang-Yu Hu, Shih-Chiang Lin, Le-Jung Wu, Yu-Chin Lin, Yu-Jen Chen, Li-Ying Wang, Yen-Ping Hsieh, Shoei Long Lin, Chun-Yi Chen, Chien-An Chen and Pei-Wei Shueng
    Citation: BMC Cancer 2011 11:37
  42. The incidence of non-Hodgkin's lymphoma has increased over recent years. The exact etiology of lymphoma remains unknown. Ultraviolet light exposure has been associated with the development of internal lymphoid...

    Authors: Nahum Puebla-Osorio, Yasuko Miyahara, Sreevidya Coimbatore, Alberto Y Limón-Flores, Nasser Kazimi, Stephen E Ullrich and Chengming Zhu
    Citation: BMC Cancer 2011 11:36
  43. The DNA repair protein O6-Methylguanine-DNA methyltransferase (MGMT) confers resistance to alkylating agents. Several methods have been applied to its analysis, with methylation-specific polymerase chain reaction...

    Authors: Marta Brell, Javier Ibáñez and Avelina Tortosa
    Citation: BMC Cancer 2011 11:35
  44. Due to considerable health status differences in the elderly population, research limited to narrow age-spans might be an advantage. In this population-based controlled study we compare short-term (<5 years) (...

    Authors: Ellen K Grov, Sophie D Fosså and Alv A Dahl
    Citation: BMC Cancer 2011 11:34
  45. Neuroblastoma is a paediatric cancer which originates from precursor cells of the sympathetic nervous system and accounts for 15% of childhood cancer mortalities. With regards to the role of miRNAs in neurobla...

    Authors: Amanda Tivnan, Lorraine Tracey, Patrick G Buckley, Leah C Alcock, Andrew M Davidoff and Raymond L Stallings
    Citation: BMC Cancer 2011 11:33
  46. Activating mutations of the epidermal growth factor receptor (EGFR) confer sensitivity to the tyrosine kinase inhibitors (TKi), gefitinib and erlotinib. We analysed EGFR expression, EGFR mutation status and gene ...

    Authors: Caterina Peraldo-Neia, Giorgia Migliardi, Maurizia Mello-Grand, Filippo Montemurro, Raffaella Segir, Ymera Pignochino, Giuliana Cavalloni, Bruno Torchio, Luciano Mosso, Giovanna Chiorino and Massimo Aglietta
    Citation: BMC Cancer 2011 11:31
  47. The c-Myb transcription factor regulates differentiation and proliferation in hematopoietic cells, stem cells and epithelial cells. Although oncogenic versions of c-Myb were first associated with leukemias, ov...

    Authors: Anita M Quintana, Fan Liu, John P O'Rourke and Scott A Ness
    Citation: BMC Cancer 2011 11:30

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