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  1. Radiotherapy for head and neck cancer results in severe and chronic salivary gland dysfunction in most individuals. This results in significant side effects including xerostomia, dysphagia, and malnutrition wh...

    Authors: Oliver Grundmann, Jamia L Fillinger, Kerton R Victory, Randy Burd and Kirsten H Limesand
    Citation: BMC Cancer 2010 10:417
    Content type: Research article Published on:

  2. Genetically, colorectal cancers (CRCs) can be subdivided into tumors with chromosomal instability (CIN) or microsatellite instability (MSI). In both types of CRCs genes that are involved in the degradation of ...

    Authors: Silvio K Scheel, Marc Porzner, Sabine Pfeiffer, Steffen Ormanns, Thomas Kirchner and Andreas Jung
    Citation: BMC Cancer 2010 10:413
    Content type: Research article Published on:

  3. Breast cancer treatment is based on a combination of adjuvant chemotherapy followed by radiotherapy effecting intracellular signal transduction. With the tyrosine kinase inhibitors new targeted drugs are avail...

    Authors: Marion T Weigel, Linda Dahmke, Christian Schem, Dirk O Bauerschlag, Katrin Weber, Peter Niehoff, Maret Bauer, Alexander Strauss, Walter Jonat, Nicolai Maass and Christoph Mundhenke
    Citation: BMC Cancer 2010 10:412
    Content type: Research article Published on:

  4. Breast cancer cells with CD44+/CD24- cell surface marker expression profile are proposed as cancer stem cells (CSCs). Normal breast epithelial cells that are CD44+/CD24- express higher levels of stem/progenito...

    Authors: Poornima Bhat-Nakshatri, Hitesh Appaiah, Christopher Ballas, Patricia Pick-Franke, Robert Goulet Jr, Sunil Badve, Edward F Srour and Harikrishna Nakshatri
    Citation: BMC Cancer 2010 10:411
    Content type: Research article Published on:

  5. Studies of several tumour types have shown that expression profiling of cellular protein extracted from surgical tissue specimens by direct mass spectrometry analysis can accurately discriminate tumour from no...

    Authors: Christopher CL Liao, Nicholas Ward, Simon Marsh, Tan Arulampalam and John D Norton
    Citation: BMC Cancer 2010 10:410
    Content type: Research article Published on:

  6. Elevated Hsp90 expression has been documented in breast ductal carcinomas, whereas decreased Hsp90 expression has been reported in precursor lobular lesions. This study aims to assess Hsp90 expression in infil...

    Authors: Flora Zagouri, Theodoros Sergentanis, Afrodite Nonni, Christos Papadimitriou, Anastasia Pazaiti, Nikolaos V Michalopoulos, Panagiotis Safioleas, Andreas Lazaris, George Theodoropoulos, Effstratios Patsouris and George Zografos
    Citation: BMC Cancer 2010 10:409
    Content type: Research article Published on:

  7. MUTYH-associated polyposis (MAP) is a disorder caused by bi-allelic germline MUTYH mutation, characterized by multiple colorectal adenomas. In order to identify mutations in MUTYH gene we applied High Resolution...

    Authors: Isabel López-Villar, Rosa Ayala, Jan Wesselink, Juan Diego Morillas, Elena López, José Carlos Marín, José Díaz-Tasende, Sara González, Luis Robles and Joaquín Martínez-López
    Citation: BMC Cancer 2010 10:408
    Content type: Research article Published on:

  8. Neurofibromatosis type 1 is a common autosomal dominant disorder with full penetrance and variable expression. The condition predisposes individuals to the development of malignant nervous system tumours, most...

    Authors: German Melean, Alba Marina Hernández, María Carmen Valero, Elisabete Hernández-Imaz, Yolanda Martín and Concepción Hernández-Chico
    Citation: BMC Cancer 2010 10:407
    Content type: Case report Published on:

  9. Cancer patients may benefit from physical exercise programs. It is unclear, however, how sustained levels of physical activity are best achieved in this population. A systematic review was performed to summari...

    Authors: Ruud H Knols, Eling D de Bruin, Kei Shirato, Daniel Uebelhart and Neil K Aaronson
    Citation: BMC Cancer 2010 10:406
    Content type: Research article Published on:

  11. The response to treatment varies among patients with multiple myeloma and markers for prediction of treatment outcome are highly needed. Bioactivation of cyclophosphamide and thalidomide, and biodegradation of...

    Authors: Annette J Vangsted, Karen Søeby, Tobias W Klausen, Niels Abildgaard, Niels F Andersen, Peter Gimsing, Henrik Gregersen, Ulla Vogel, Thomas Werge and Henrik B Rasmussen
    Citation: BMC Cancer 2010 10:404
    Content type: Research article Published on:

  12. Siah proteins play an important role in cancer progression. We evaluated the effect of Siah1, its splice variants Siah1L and the Siah1 mutant with the RING finger deleted (Siah1ΔR) on radiosensitization of hum...

    Authors: Hai-Tao He, Emmanouil Fokas, An You, Rita Engenhart-Cabillic and Han-Xiang An
    Citation: BMC Cancer 2010 10:403
    Content type: Research article Published on:

  13. Colorectal peritoneal carcinomatosis (CRPC) is a common form of systemic metastasis of intra-abdominal cancers. Intraperitoneal chemotherapy is a preferable option for colorectal cancer. Here we reported that ...

    Authors: Yongsheng Wang, Changyang Gong, Li Yang, Qinjie Wu, Shuai Shi, Huashan Shi, Zhiyong Qian and Yuquan Wei
    Citation: BMC Cancer 2010 10:402
    Content type: Research article Published on:

  14. Gene mutation is an important mechanism of myeloid leukemogenesis. However, the number and combination of gene mutated in myeloid malignancies is still a matter of investigation.

    Authors: Julien Rocquain, Nadine Carbuccia, Virginie Trouplin, Stéphane Raynaud, Anne Murati, Meyer Nezri, Zoulika Tadrist, Sylviane Olschwang, Norbert Vey, Daniel Birnbaum, Véronique Gelsi-Boyer and Marie-Joelle Mozziconacci
    Citation: BMC Cancer 2010 10:401
    Content type: Research article Published on:

  15. Emerging trends and new policies suggest that more cancer patients might die at home in the future. However, not all have equal chances of achieving this. Furthermore, there is lack of evidence to support that...

    Authors: Barbara Gomes, Paul McCrone, Sue Hall, Jonathan Koffman and Irene J Higginson
    Citation: BMC Cancer 2010 10:400
    Content type: Study protocol Published on:

  16. CpG island methylator phenotype (CIMP), in which multiple genes concordantly methylated, has been demonstrated to be associated with progression, recurrence, as well as overall survival in some types of cancer.

    Authors: Li-Ming Wu, Feng Zhang, Lin Zhou, Zhe Yang, Hai-Yang Xie and Shu-Sen Zheng
    Citation: BMC Cancer 2010 10:399
    Content type: Research article Published on:

  18. Vascular endothelial growth factor (VEGF) is a primary stimulant of angiogenesis under physiological and pathological conditions. Anti-VEGF therapy is a clinically proven strategy for the treatment of a variet...

    Authors: Kristi D Lynn, D Gomika Udugamasooriya, Christina L Roland, Diego H Castrillon, Thomas J Kodadek and Rolf A Brekken
    Citation: BMC Cancer 2010 10:397
    Content type: Research article Published on:

  19. HER2 gene copy status, and concomitant administration of trastuzumab (Herceptin), remains one of the best examples of targeted cancer therapy based on understanding the genomic etiology of disease. However, newl...

    Authors: Shelly Gunn, I-Tien Yeh, Irina Lytvak, Budi Tirtorahardjo, Natasha Dzidic, Soheila Zadeh, Jaeweon Kim, Chris McCaskill, Lony Lim, Mercedes Gorre and Mansoor Mohammed
    Citation: BMC Cancer 2010 10:396
    Content type: Technical advance Published on:

  20. Mutations of the MEN1 gene predispose to multiple endocrine neoplasia type 1 (MEN1) syndrome. Our group and others have shown that Men1 disruption in mice recapitulates MEN1 pathology. Intriguingly, rare lesions ...

    Authors: Christelle Seigne, Sandra Fontanière, Christine Carreira, Jieli Lu, Wei-Ming Tong, Bernard Fontanière, Zhao-Qi Wang, Chang Xian Zhang and Lucien Frappart
    Citation: BMC Cancer 2010 10:395
    Content type: Research article Published on:

  21. NF-κB is a survival signaling transcription factor complex involved in the malignant phenotype of many cancers, including squamous cell carcinomas (SCC). The citrus coumarin, auraptene (AUR), and the ethno-med...

    Authors: Heather E Kleiner-Hancock, Runhua Shi, Angela Remeika, Delira Robbins, Misty Prince, Jennifer N Gill, Zanobia Syed, Patrick Adegboyega, J Michael Mathis and John L Clifford
    Citation: BMC Cancer 2010 10:394
    Content type: Research article Published on:

  22. The hTERT (human telomerase reverse transcriptase) gene contains five variable number tandem repeats (VNTR) and previous studies have described polymorphisms for hTERT-VNTR2-2nd. We investigated how allelic varia...

    Authors: Se-Lyun Yoon, Se-Il Jung, Eun-Ju Do, Se-Ra Lee, Sang-Yeop Lee, In-Sun Chu, Wun-Jae Kim, Jaeil Jung, Choung Soo Kim, Sang-Hyeon Cheon and Sun-Hee Leem
    Citation: BMC Cancer 2010 10:393
    Content type: Research article Published on:

  23. Cinnamomum cassia bark is the outer skin of an evergreen tall tree belonging to the family Lauraceae containing several active components such as essential oils (cinnamic aldehyde and cinnamyl aldehyde), tannin,...

    Authors: Ho-Keun Kwon, Ji-Sun Hwang, Jae-Seon So, Choong-Gu Lee, Anupama Sahoo, Jae-Ha Ryu, Won Kyung Jeon, Byoung Seob Ko, Chang-Rok Im, Sung Haeng Lee, Zee Yong Park and Sin-Hyeog Im
    Citation: BMC Cancer 2010 10:392
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:1113

  25. Breast cancer is one the highest causes of female cancer death worldwide. Many standard chemotherapeutic agents currently used to treat breast cancer are relatively non-specific and act on all rapidly dividing...

    Authors: Fariborz Rashid-Kolvear, Michael AS Taboski, Johnny Nguyen, Dong-Yu Wang, Lea A Harrington and Susan J Done
    Citation: BMC Cancer 2010 10:390
    Content type: Research article Published on:

  26. Familial adenomatous polyposis, an autosomal dominant inherited disease caused by germline mutations within the APC gene, is characterized by early onset colorectal cancer as a consequence of the intrinsic phenot...

    Authors: Florentia Fostira, Georgia Thodi, Raphael Sandaltzopoulos, George Fountzilas and Drakoulis Yannoukakos
    Citation: BMC Cancer 2010 10:389
    Content type: Research article Published on:

  27. Cancer cells recurrently develop into acquired resistance to the administered drugs. The iatrogenic mechanisms of induced chemotherapy-resistance remain elusive and the degree of drug resistance did not exclus...

    Authors: Ji Yeon Yang, Seon-Ah Ha, Yun-Sik Yang and Jin Woo Kim
    Citation: BMC Cancer 2010 10:388
    Content type: Research article Published on:

  28. Histone deacetylase (HDAC) inhibitors are a novel anti-tumor therapy. To determine whether HDAC inhibitors may be useful in the treatment of adult acute lymphoblastic leukemia (ALL), we examined the acetylatio...

    Authors: Anjali S Advani, Sarah E Gibson, Elizabeth Douglas, Tao Jin, Xiaoxian Zhao, Matt Kalaycio, Ed Copelan, Ronald Sobecks, Mikkael Sekeres, Shawnda Sungren and Eric D Hsi
    Citation: BMC Cancer 2010 10:387
    Content type: Research article Published on:

  29. Melanoma is an aggressive tumor with increasing incidence. To develop accurate prognostic markers and targeted therapies, changes leading to malignant transformation of melanocytes need to be understood. In the X...

    Authors: Janka Teutschbein, Johannes M Haydn, Birgit Samans, Michael Krause, Martin Eilers, Manfred Schartl and Svenja Meierjohann
    Citation: BMC Cancer 2010 10:386
    Content type: Research article Published on:

  30. Neuroendocrine (NE) differentiation in prostate cancer has been correlated with a poor prognosis and hormone refractory disease. In a previous report, we demonstrated the presence of immunoreactive cytoplasmic...

    Authors: Nastaran Monsef, Maria Soller, Ioannis Panagopoulos and Per Anders Abrahamsson
    Citation: BMC Cancer 2010 10:385
    Content type: Research article Published on:

  31. Glioblastoma is the most common brain tumor in adults. The mechanisms leading to glioblastoma are not well understood but animal studies support that inactivation of tumor suppressor genes in neural stem cells...

    Authors: Patrick Evers, Percy P Lee, John DeMarco, Nzhde Agazaryan, James W Sayre, Michael Selch and Frank Pajonk
    Citation: BMC Cancer 2010 10:384
    Content type: Research article Published on:

  33. Endometrial cancer is the most common gynaecological malignancy in women of developed countries. Many risk factors implicated in endometrial cancer trigger inflammatory events; therefore, alterations in immune...

    Authors: Katie A Ashton, Anthony Proietto, Geoffrey Otton, Ian Symonds, Mark McEvoy, John Attia and Rodney J Scott
    Citation: BMC Cancer 2010 10:382
    Content type: Research article Published on:

  35. Activation of the extrinsic apoptosis pathway by tumour necrosis factor related apoptosis inducing ligand (TRAIL) is a novel therapeutic strategy for treating cancer that is currently under clinical evaluation...

    Authors: Alex D Chacko, Fabio Liberante, Ian Paul, Daniel B Longley and Dean A Fennell
    Citation: BMC Cancer 2010 10:380
    Content type: Research article Published on:

  36. Pancreatic ductal adenocarcinoma shows a distinct apoptosis resistance, which contributes significantly to the aggressive nature of this tumor and constrains the effectiveness of new therapeutic strategies. Ap...

    Authors: Felix Rückert, Nicole Samm, Anne-Kathrin Lehner, Hans-Detlev Saeger, Robert Grützmann and Christian Pilarsky
    Citation: BMC Cancer 2010 10:379
    Content type: Research article Published on:

  37. Metastasis represents a major adverse step in the progression of breast carcinoma. Lymph node invasion is the most relevant prognostic factor; however little is known on the molecular events associated with ly...

    Authors: Weiwei Feng, Rosaria Orlandi, Naiqing Zhao, Maria Luisa Carcangiu, Elda Tagliabue, Jia Xu, Robert C Bast Jr and Yinhua Yu
    Citation: BMC Cancer 2010 10:378
    Content type: Research article Published on:

  38. According to the different sensitivity of their bone marrow CD34+ cells to in vitro treatment with Etoposide or Mafosfamide, Acute Myeloid Leukaemia (AML) patients in apparent complete remission (CR) after chemot...

    Authors: Marco Ragusa, Giuseppe Avola, Rosario Angelica, Davide Barbagallo, Maria Rosa Guglielmino, Laura R Duro, Alessandra Majorana, Luisa Statello, Loredana Salito, Carla Consoli, Maria Grazia Camuglia, Cinzia Di Pietro, Giuseppe Milone and Michele Purrello
    Citation: BMC Cancer 2010 10:377
    Content type: Research article Published on:

  40. Infiltration by macrophages (Mφ) indicates a poor prognosis in breast cancers, in particular by inducing angiogenesis. Our study aimed 1) to investigate the mechanism by which cooperation between Mφ and aggres...

    Authors: Ulrich Joimel, Caroline Gest, Jeannette Soria, Linda-Louise Pritchard, Jérôme Alexandre, Marc Laurent, Emmanuel Blot, Lionel Cazin, Jean-Pierre Vannier, Rémi Varin, Hong Li and Claudine Soria
    Citation: BMC Cancer 2010 10:375
    Content type: Research article Published on:

  41. Aimed to assess the relationship between H.Pylori and the clinicopathological features and prognosis of gastric cancer by quantitative detection of H.Pylori.

    Authors: Hai-Bo Qiu, Li-Yi Zhang, Rajiv-Prasad Keshari, Guo-Qiang Wang, Zhi-Wei Zhou, Da-Zhi Xu, Wei Wang, You-Qin Zhan and Wei Li
    Citation: BMC Cancer 2010 10:374
    Content type: Research article Published on:

  42. Recent research has yielded a wealth of data underscoring the key role of the cancer microenvironment, especially immune and stromal cells, in the progression of cancer and the development of metastases. Howev...

    Authors: Joanna M Poczobutt, John Tentler, Xian Lu, Pepper J Schedin and Arthur Gutierrez-Hartmann
    Citation: BMC Cancer 2010 10:373
    Content type: Research article Published on:

  43. Hypoxia regulates gene expression via the transcription factor HIF (Hypoxia-Inducible Factor). Little is known regarding HIF expression and function in primary bone sarcomas. We describe HIF expression and phe...

    Authors: Helen J Knowles, Karl-Ludwig Schaefer, Uta Dirksen and Nicholas A Athanasou
    Citation: BMC Cancer 2010 10:372
    Content type: Research article Published on:

  44. The aims of this study were to determine the accuracy of concurrent core needle biopsy (CNB) and fine needle aspiration biopsy (FNAB) for breast lesions and to estimate the false-negative rate using the two me...

    Authors: Yao-Lung Kuo and Tsai-Wang Chang
    Citation: BMC Cancer 2010 10:371
    Content type: Research article Published on:

  45. Chloroquine (CQ), the worldwide used anti-malarial drug, has recently being focused as a potential anti-cancer agent as well as a chemosensitizer when used in combination with anti-cancer drugs. It has been sh...

    Authors: Kazuhito Sasaki, Nelson H Tsuno, Eiji Sunami, Giichiro Tsurita, Kazushige Kawai, Yurai Okaji, Takeshi Nishikawa, Yasutaka Shuno, Kumiko Hongo, Masaya Hiyoshi, Manabu Kaneko, Joji Kitayama, Koki Takahashi and Hirokazu Nagawa
    Citation: BMC Cancer 2010 10:370
    Content type: Research article Published on:

  46. Matrix metalloproteinases (MMPs) are enzymes that degrade all the components of extra cellular matrix and collagen. Various types of MMPs are known to be expressed and activated in patients with oral submucous...

    Authors: Ajay K Chaudhary, Mamta Singh, Alok C Bharti, Mangal Singh, Shirish Shukla, Atul K Singh and Ravi Mehrotra
    Citation: BMC Cancer 2010 10:369
    Content type: Research article Published on:

  47. The phosphoinositide 3-kinase (PI3K)/Akt pathway is constitutively activated in pancreatic cancer and the mammalian target of rapamycin (mTOR) kinase is an important mediator for its signaling. Our recent in vitr...

    Authors: Milind M Javle, Rachna T Shroff, Henry Xiong, Gauri A Varadhachary, David Fogelman, Shrikanth A Reddy, Darren Davis, Yujian Zhang, Robert A Wolff and James L Abbruzzese
    Citation: BMC Cancer 2010 10:368
    Content type: Research article Published on:

  48. MicroRNAs (miRNAs) can function as either oncogenes or tumor suppressor genes via regulation of cell proliferation and/or apoptosis. MiR-221 and miR-222 were discovered to induce cell growth and cell cycle pro...

    Authors: Zhang Chun-zhi, Han Lei, Zhang An-ling, Fu Yan-chao, Yue Xiao, Wang Guang-xiu, Jia Zhi-fan, Pu Pei-yu, Zhang Qing-yu and Kang Chun-sheng
    Citation: BMC Cancer 2010 10:367
    Content type: Research article Published on:

  49. DNA methylation and histone acetylation are epigenetic modifications that act as regulators of gene expression. Aberrant epigenetic gene silencing in tumours is a frequent event, yet the factors which dictate ...

    Authors: David Mossman, Kyu-Tae Kim and Rodney J Scott
    Citation: BMC Cancer 2010 10:366
    Content type: Research article Published on:

  50. The formation of metastasis is the most common cause of death in patients with lung cancer. A major implement to understand the molecular mechanisms involved in lung cancer metastasis has been the lack of suit...

    Authors: Deshui Jia, Mingxia Yan, Xiaomin Wang, Xiangfang Hao, Linhui Liang, Lei Liu, Hanwei Kong, Xianghuo He, Jinjun Li and Ming Yao
    Citation: BMC Cancer 2010 10:364
    Content type: Research article Published on:

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