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  1. Conventional differential expression (DE) testing compares the grouped mean value of tumour samples to the grouped mean value of the normal samples, and may miss out dysregulated genes in small subgroup of pat...

    Authors: Ah-Jung Jeon, Yue-Yang Teo, Karthik Sekar, Shay Lee Chong, Lingyan Wu, Sin-Chi Chew, Jianbin Chen, Raden Indah Kendarsari, Hannah Lai, Wen Huan Ling, Neslihan Arife Kaya, Jia Qi Lim, Adaikalavan Ramasamy, Gokce Oguz, Alexander Yaw-Fui Chung, Chung Yip Chan…
    Citation: BMC Cancer 2023 23:118
  2. Recurrence due to the development of radioresistance remains a major challenge in the clinical management of nasopharyngeal carcinoma. The objective of this study was to increase the sensitivity of nasopharyng...

    Authors: Alvan Amos, Ning Jiang, Dan Zong, Jiajia Gu, Jiawei Zhou, Li Yin, Xia He, Yong Xu and Lirong Wu
    Citation: BMC Cancer 2023 23:117
  3. Childhood cancer survivors (CCS) are at increased risk of cardiomyopathy during pregnancy if they have prior cardiotoxic exposure. Currently, there is no consensus on the necessity, timing and modality of card...

    Authors: Julius C. Heemelaar, Steffie Heemelaar, Svenja N. Hertel, J. Wouter Jukema, Marieke Sueters, Marloes Louwerens and M. Louisa Antoni
    Citation: BMC Cancer 2023 23:115
  4. In low-resource settings with weak health systems, the WHO recommends clinical breast examination (CBE) as the most cost-effective breast screening modality for women. Evidence shows that biennial CBE leads to...

    Authors: Agani Afaya, Timothy Tienbia Laari, Abdul Aziz Seidu, Richard Adongo Afaya, Silas Selorm Daniels-Donkor, Vida Nyagre Yakong and Bright Opoku Ahinkorah
    Citation: BMC Cancer 2023 23:114
  5. Immune checkpoint inhibitor (ICI) therapy has become a viable treatment strategy in bladder cancer. However, treatment responses vary, and improved biomarkers are needed. Crucially, the characteristics of immu...

    Authors: Max Jung, Michael Rose, Ruth Knuechel, Chiara Loeffler, Hannah Muti, Jakob Nikolas Kather and Nadine T. Gaisa
    Citation: BMC Cancer 2023 23:113
  6. The TROIKA trial established that HD201 and trastuzumab were equivalent in terms of primary endpoints (total pathological complete response) following neoadjuvant treatment. The objective of the present analys...

    Authors: Xavier Pivot, Alexey Georgievitch Manikhas, Volodymyr Shamrai, Giorgi Dzagnidze, Hwoei Fen Soo Hoo, Viriya Kaewkangsadan, Fausto Petrelli, Cristian Villanueva, Jamie Kim, Sumita Pradhan, Litha Jaison, Peggy Feyaerts, Leonard Kaufman, Marie-Paule Derde, Filip Deforce and David G. Cox
    Citation: BMC Cancer 2023 23:112
  7. Early diagnosis of lung adenocarcinoma (LUAD), one of the most common types of lung cancer, is very important to improve the prognosis of patients. The current methods can’t meet the requirements of early diag...

    Authors: Junfeng Li, Jianjie Li, Huifeng Hao, Fangliang Lu, Jia Wang, Menglei Ma, Bo Jia, Minglei Zhuo, Jingjing Wang, Yujia Chi, Xiaoyu Zhai, Yuyan Wang, Meina Wu, Tongtong An, Jun Zhao, Fan Yang…
    Citation: BMC Cancer 2023 23:110
  8. Transcatheter arterial embolization (TAE) has long been used for hemostasis of traumatic or postoperative hemorrhage and embolization of tumors. Previous retrospective studies of TAE for painful bone metastase...

    Authors: Sadamoto Zenda, Yasunori Arai, Shunsuke Sugawara, Yoshitaka Inaba, Kazuki Hashimoto, Kouji Yamamoto, Yusuke Saigusa, Takashi Kawaguchi, Sanae Shimada, Marie Yokoyama, Tempei Miyaji, Tomoka Okano, Naoki Nakamura, Eisuke Kobayashi, Tatsuya Takagi, Yoshihisa Matsumoto…
    Citation: BMC Cancer 2023 23:109
  9. As the dominant component of the tumor microenvironment, cancer-associated fibroblasts (CAFs), play a vital role in tumor progression. An increasing number of studies have confirmed that CAFs are involved in a...

    Authors: Zhiyang Zhou, Sixuan Guo, Shuhui Lai, Tao Wang, Yao Du, Junping Deng, Shun Zhang, Ge Gao and Jiangnan Zhang
    Citation: BMC Cancer 2023 23:108
  10. A more effective immune response against glioblastoma is needed in order to achieve better tumor control. Radiotherapy can induce anti-tumor mediated immune reactions, in addition to its dose response effects....

    Authors: Emma Liljedahl, Elise Konradsson, Emma Gustafsson, Karolina Förnvik Jonsson, Jill K. Olofsson, Kurt Osther, Crister Ceberg and Henrietta Nittby Redebrandt
    Citation: BMC Cancer 2023 23:106
  11. Cuproptosis, an emerging form of programmed cell death, has recently been identified. However, the association between cuproptosis-related long non-coding RNA (lncRNA) signature and the prognosis in prostate c...

    Authors: Xiaofeng Cheng, Zhenhao Zeng, Heng Yang, Yujun Chen, Yifu Liu, Xiaochen Zhou, Cheng Zhang and Gongxian Wang
    Citation: BMC Cancer 2023 23:105
  12. To explore the potential pathogenesis and clinical features of second primary glioblastoma (spGBM) following first primary renal cell carcinoma (fpRCC).

    Authors: Guang-Tao Zhang, Qi Liu, Fu-Xing Zuo, Hou-Jie Liu, Song-Quan Wang, Qing Yuan, Ang-Si Liu, Ke Hu, Xiao-Li Meng, Wei-Jia Wang, Hai-Peng Qian, Jing-Hai Wan and Hong-Qing Cai
    Citation: BMC Cancer 2023 23:104
  13. Real-world data of Palbociclib are insufficient in China. This study aimed to investigate the treatment pattern and real-world outcomes in hormone receptor positive and human epidermal growth factor 2 receptor...

    Authors: Jiao Yang, Bing Zhao, Xiaoling Ling, Donghui Li, Jiuda Zhao, Yonggang Lv, Guangxi Wang, Xinlan Liu, Nanlin Li and Jin Yang
    Citation: BMC Cancer 2023 23:103
  14. CD276 (also known as B7-H3) is one of the most important immune checkpoints of the CD28 and B7 superfamily, and its abnormal expression is closely associated with various types of cancer. It has been shown that C...

    Authors: Lirui Dai, Xuyang Guo, Zhe Xing, Yiran Tao, Wulong Liang, Zimin Shi, Weihua Hu, Shaolong Zhou and Xinjun Wang
    Citation: BMC Cancer 2023 23:102
  15. Systemic inflammation is crucial for the development and progression of cancers. The advanced lung cancer inflammation index (ALI) is considered to be a better indicator of systemic inflammation than current b...

    Authors: Lilong Zhang, Kailiang Zhao, Tianrui kuang, Kunpeng Wang, Dongqi Chai, Zhendong Qiu, Rongqiang Liu, Wenhong Deng and Weixing Wang
    Citation: BMC Cancer 2023 23:101
  16. The aim of this paper was to clarify the optimal minimum number of lymph node for CEA-elevated (≥ 5 ng/ml) colon cancer patients.

    Authors: Hao Zhang, Chunlin Wang, Yunxiao Liu, Hanqing Hu, Qingchao Tang, Rui Huang, Meng Wang and Guiyu Wang
    Citation: BMC Cancer 2023 23:100
  17. Both Red Blood Cell (RBC) transfusion and anemia are thought to negatively impact cancer survival. These effects have been reported with mixed findings in cancer of the esophagus. The potential impact of the a...

    Authors: Joseph P. Connor, Eric Destrampe, Daniel Robbins, Aaron S. Hess, Daniel McCarthy and James Maloney
    Citation: BMC Cancer 2023 23:99
  18. To compare the effectiveness of high-resolution dermal ultrasound (US) guided superficial radiotherapy (SRT) to non-image-guided radiotherapy in the treatment of early-stage Non-Melanoma Skin Cancer (NMSC).

    Authors: Lio Yu, Mairead Moloney, Songzhu Zheng and James Rogers
    Citation: BMC Cancer 2023 23:98
  19. Distant metastasis remains the main cause of death in breast cancer. Breast cancer risk is strongly influenced by pathogenic mutation.This study was designed to develop a multiple-feature model using clinicopa...

    Authors: Zhenzhen Shao, Jinpu Yu, Yanan Cheng, Wenjuan Ma, Peifang Liu and Hong Lu
    Citation: BMC Cancer 2023 23:97
  20. High expression of SETD1A, a histone methyltransferase that specifically methylates H3K4, acted as a key oncogene in several human cancers. However, the function and underlying molecular mechanism of SETD1A in...

    Authors: Hongjuan Chai, Chunpeng Pan, Mingyang Zhang, Haizhong Huo, Haiyan Shan and Jugang Wu
    Citation: BMC Cancer 2023 23:96
  21. To evaluate the overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) for primary cervical lymphoma (PCL), an extremely rare disease without treatment consensus.

    Authors: Lingyun Gao, Xiaoran Chen, Jing Zhao, Anli Xu, Meijuan Liu, Hongna Yu, Shujun Kong and Sijian Li
    Citation: BMC Cancer 2023 23:95
  22. PRECONNECT was an international, phase IIIb trial evaluating the safety and efficacy of trifluridine/tipiracil (FTD/TPI) for metastatic colorectal cancer (mCRC).

    Authors: Julien Taieb, Timothy Price, Loïck Vidot, Bénédicte Chevallier, Lucjan Wyrwicz and Jean-Baptiste Bachet
    Citation: BMC Cancer 2023 23:94
  23. This retrospective study explored the relationship between hormone receptor (HR), human epidermal growth factor receptor 2 (HER2) status, and bone involvement in the first distant metastases (DM) of Chinese br...

    Authors: Zhifeng Jia, Muwei Dai, Yuguang Shang, Yue Li and Zhensheng Li
    Citation: BMC Cancer 2023 23:93
  24. Understanding the latest global spatio-temporal pattern of prostate cancer burden attributable to smoking can help guide effective global health policy. This study aims to elucidate the trends in smoking-relat...

    Authors: Hanfei Zhang, Dingping Huang, Yingfeng Zhang, Xia Wang, Jiangtao Wu and Daqing Hong
    Citation: BMC Cancer 2023 23:92
  25. Ovarian cancer is a leading cause of female mortality. Epigenetic changes occur in early stages of carcinogenesis and represent a marker for cancer diagnosis. Protocadherin 17 (PCDH17) is a tumor suppressor gene ...

    Authors: Sherif Mohamed Elsharkawi, Dalal Elkaffash, Pacint Moez, Nour El-Etreby, Eman Sheta and Raghda Saad Zaghloul Taleb
    Citation: BMC Cancer 2023 23:89
  26. Magnetic resonance imaging (MRI) performs well in the locoregional assessment of extranodal nasal-type NK/T-cell lymphoma (ENKTCL). It’s important to assess the value of multi-modal MRI-based radiomics for est...

    Authors: Yu-Ting Zhao, Si-Ye Chen, Xin Liu, Yong Yang, Bo Chen, Yong-Wen Song, Hui Fang, Jing Jin, Yue-Ping Liu, Hao Jing, Yuan Tang, Ning Li, Ning-Ning Lu, Shu-Lian Wang, Han Ouyang, Chen Hu…
    Citation: BMC Cancer 2023 23:88
  27. Insulin-like growth factor-1 receptor (IGF-1R) promotes cell proliferation and migration and inhibitsapoptosis, all of which can contribute to the development of cancers.

    Authors: Wenpeng Cai, Yongfang Ma, Li Song, Niandie Cao, Jiafeng Gao, Shuping Zhou and Xiaolong Tang
    Citation: BMC Cancer 2023 23:87
  28. Tumor micronecrosis is a histopathological feature predicting poor prognosis in patients with hepatocellular carcinoma (HCC) who underwent liver resection. However, the role of tumor micronecrosis in liver tra...

    Authors: Yangyang Wang, Wei Zhang, Hongbin Ge, Xu Han, Jiangchao Wu, Xuqi Sun, Ke Sun, Wanyue Cao, Chao Huang, Jingsong Li, Qi Zhang and Tingbo Liang
    Citation: BMC Cancer 2023 23:86
  29. While molecular targeted drugs and other therapies are being developed for many tumors, pancreatic cancer is still considered to be the malignant tumor with the worst prognosis. We started this study to identi...

    Authors: Shoichiro Tange, Tomomi Hirano, Masashi Idogawa, Eishu Hirata, Issei Imoto and Takashi Tokino
    Citation: BMC Cancer 2023 23:85
  30. Breast cancer patients of American Society of Clinical Oncology and the College of American Pathologists (ASCO/CAP) Group 2 were all HER2-negative according to the 2018 guideline, not HER2-positive as defined ...

    Authors: Shuling Zhou, Hong Lv, Anqi Li, Ming Li, Siyuan Zhong, Hongfen Lu, Xiaoyan Zhou, Qianming Bai and Wentao Yang
    Citation: BMC Cancer 2023 23:84
  31. Programmed Cell Death-1/ Programmed Death-ligand 1 (PD-1 / PD-L1) inhibitor therapies targeting immunocytes induce persistent tumor remission in various cancers. However, the appropriate biomarkers for the the...

    Authors: Xiaoyue Du, Shaodi Wen, Run Shi, Jingwei Xia, Ruotong Wang, Yihan Zhang, Banzhou Pan, Xiaoliu Wu, Wei Zhu, Jifeng Feng, Xin Wang and Bo Shen
    Citation: BMC Cancer 2023 23:83
  32. Mastocytosis is a very rare disorder and is divided into three prognostically distinct variants by World Health Organization: Cutaneous mastocytosis (CM), systemic mastocytosis (SM), and mast cell sarcoma or l...

    Authors: Tarık Onur Tiryaki, Sıdıka Gülkan Özkan, Simge Erdem, Aynur Dağlar Aday, İpek Yönal Hindilerden, Aslı Gelincik, Can Baykal, Gülçin Yegen, İbrahim Öner Doğan, Nesimi Büyükbabani, Meliha Nalçacı and Akif Selim Yavuz
    Citation: BMC Cancer 2023 23:82
  33. Childhood cancer (CC) is a leading cause of death among children aged 0–19 years worldwide. Each year, 400,000 new cases of CC are diagnosed globally. Given the between-country differences in CC incidence rate...

    Authors: Manushak Avagyan, Anahit Demirchyan and Lusine Abrahamyan
    Citation: BMC Cancer 2023 23:81
  34. Smoking is a modifiable risk factor for cancers. The aim of the study is to estimate the trend of mortality and DALYs of smoking-attributed cancers in the North Africa and Middle East (NAME) countries.

    Authors: Leila Rezakhani, Mitra Darbandi, Zahra Khorrami, Shima Rahmati and Fatemeh Khosravi Shadmani
    Citation: BMC Cancer 2023 23:80
  35. Cervical cancer is currently estimated to be the fourth most common cancer among women worldwide and the leading cause of cancer-related deaths in some of the world’s poorest countries. C/EBPβ has tumor suppre...

    Authors: Haichen Long, Yangyang Li, Huijuan Wang, Bingxuan Guo, Shuyan Song, Xiangyi Zhe, Hongtao Li, Dongmei Li, Renfu Shao and Zemin Pan
    Citation: BMC Cancer 2023 23:79
  36. Incidence and risk factors for seizures among women with advanced breast cancer (BC) and brain metastases are not well characterized across treatment-related or clinical subtypes. This study leveraged a large ...

    Authors: Alexander Liede, Wendy Sebby, Ashok Kumar Reddy Miriyala, Ravi Potluri, Debasish Mazumder, Anirban Ghosh, Eros Papademetriou, Ryan Kilpatrick and Jerzy E. Tyczynski
    Citation: BMC Cancer 2023 23:78
  37. Precision medicine with gene panel testing based on next-generation sequencing for patients with cancer is being used increasingly in clinical practice. HER2, which encodes the human epidermal growth factor recep...

    Authors: Yohei Harada, Akemi Sato, Hideaki Nakamura, Keita Kai, Sho Kitamura, Tomomi Nakamura, Yuki Kurihara, Sadakatsu Ikeda, Eisaburo Sueoka, Shinya Kimura and Naoko Sueoka-Aragane
    Citation: BMC Cancer 2023 23:77
  38. Gastric cancer peritoneal metastasis (GCPM) is an important cause of cancer-related deaths worldwide. Long non-coding RNAs (lncRNAs) play a key role in the regulation of GCPM, but the underlying mechanisms hav...

    Authors: Chao Dong, Fujuan Luan, Wenyan Tian, Kaipeng Duan, Tao Chen, Jiayu Ren, Weikang Li, Dongbao Li, Qiaoming Zhi and Jin Zhou
    Citation: BMC Cancer 2023 23:76
  39. Patients with follicular lymphoma (FL) can have high response rates to early lines of treatment. However, among FL patients relapsed/refractory (r/r) after ≥2 prior lines of therapy (LOT), remission tends to b...

    Authors: Steve Kanters, Graeme Ball, Brad Kahl, Adriana Wiesinger, Eve H. Limbrick-Oldfield, Akshay Sudhindra, Julia Thornton Snider and Anik R. Patel
    Citation: BMC Cancer 2023 23:74
  40. Stereotactic Body Radiation Therapy (SBRT) has been found beneficial for adrenal gland metastases (AGMs) with a high local control rate and low toxicity. The role of SBRT for AGMs in patients with liver cancer...

    Authors: Bichun Xu, Xianzhi Zhao, Di Chen, Wenjuan Zhao, Xiaoyan Wang, Changhua Ding, Zhiyong Yuan and Huojun Zhang
    Citation: BMC Cancer 2023 23:73
  41. “Anti-angiogenetic drugs plus chemotherapy” (anti-angio-chemo) and “immune checkpoint inhibitors plus chemotherapy” (ICI-chemo) are superior to traditional chemotherapy in the first-line treatment of patients ...

    Authors: Lan-Lan Pang, Jia-Di Gan, Yi-Hua Huang, Jun Liao, Wei-Tao Zhuang, Wael-Abdullah-Sultan Ali, Shao-Dong Hong, Li Zhang and Wen-Feng Fang
    Citation: BMC Cancer 2023 23:72
  42. Chronic infection with Kaposi’s sarcoma-associated herpes virus (KSHV) in B lymphocytes causes primary effusion lymphoma (PEL), the most aggressive form of KSHV-related cancer, which is resistant to convention...

    Authors: Tetsunori Sakamoto, Masahiko Ajiro, Akira Watanabe, Shingo Matsushima, Keiji Ueda and Masatoshi Hagiwara
    Citation: BMC Cancer 2023 23:71
  43. Authors: D. Doppenberg, M. G. Besselink, C. H. J. van Eijck, M. P. W. Intven, B. Groot Koerkamp, G. Kazemier, H. W. M. van Laarhoven, M. Meijerink, I. Q. Molenaar, J. J. M. E. Nuyttens, R. van Os, H. C. van Santvoort, G. van Tienhoven, H. M. Verkooijen, E. Versteijne, J. W. Wilmink…
    Citation: BMC Cancer 2023 23:70

    The original article was published in BMC Cancer 2022 22:1363

  44. Nanoliposomal irinotecan plus fluorouracil/leucovorin (5-FU/LV) is a standard second-line therapy for patients with pancreatic cancer. Identification of biomarkers is important to determine appropriate treatme...

    Authors: Takeshi Kawakami, Akiko Todaka, Kotoe Oshima, Kunihiro Fushiki, Satoshi Hamauchi, Takahiro Tsushima, Tomoya Yokota, Yusuke Onozawa, Hirofumi Yasui and Kentaro Yamazaki
    Citation: BMC Cancer 2023 23:68

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