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  1. Caregivers are invaluable sources of support for individuals recovering from head and neck cancer (HNC). Accordingly, minimizing caregiver distress is essential to promote the well-being of both caregivers and...

    Authors: Zachary M. Kassir, Jinhong Li, Christine Harrison, Jonas T. Johnson and Marci L. Nilsen

    Citation: BMC Cancer 2021 21:1127

    Content type: Research

    Published on:

  2. Not all patients with unresectable hepatocellular carcinoma (uHCC) benefit from treatment with immune checkpoint inhibitors and molecular-targeted agents. The aim of this retrospective study was to assess the ...

    Authors: Song Chen, Bo Xu, Zhiqiang Wu, Pengfei Wang, Weiguang Yu, Zhiyong Liu, Xiaoyong Huang, Yanqing Wu, Tengfei Li and Wenbo Guo

    Citation: BMC Cancer 2021 21:1126

    Content type: Research

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  3. Low- and middle-income countries (LMICs) experienced increasing rates of colorectal cancer (CRC) incidence in the last decade and lower 5-year survival rates compared to high-income countries (HICs) where the ...

    Authors: Désirée Schliemann, Kogila Ramanathan, Nicholas Matovu, Ciaran O’Neill, Frank Kee, Tin Tin Su and Michael Donnelly

    Citation: BMC Cancer 2021 21:1125

    Content type: Research article

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  4. Different pathological subtypes of invasive pulmonary adenocarcinoma (IPA) have different surgical methods and heterogeneous prognosis. It is essential to clarify IPA subtypes before operation and high-resolut...

    Authors: Pengju Zhang, Tianran Li, Xuemin Tao, Xin Jin and Shaohong Zhao

    Citation: BMC Cancer 2021 21:1124

    Content type: Research article

    Published on:

  5. Favorable survival in malignant cutaneous melanoma (melanoma) has increased the likelihood of second primary cancer (SPC). We assess the influence of patient characteristics at diagnosis of first melanoma and ...

    Authors: Guoqiao Zheng, Subhayan Chattopadhyay, Kristina Sundquist, Jan Sundquist, Asta Försti, Akseli Hemminki and Kari Hemminki

    Citation: BMC Cancer 2021 21:1123

    Content type: Research

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  6. Actinomycin-D (Act-D) and Methotrexate (MTX) are both effective first-line agents for low-risk gestational trophoblastic neoplasia (LRGTN) with no consensus regarding which is more effective or less toxic. The...

    Authors: Jiatao Hao, Weihua Zhou, Mengzhao Zhang, Hui Yu, Taohong Zhang, Ruifang An and Yan Xue

    Citation: BMC Cancer 2021 21:1122

    Content type: Research

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  7. Synchronous oligometastatic non-small cell lung cancer (NSCLC) is generally characterised by the limited number of metastases at the time of diagnosis. Several clinical trials have shown that local ablative th...

    Authors: Taichi Miyawaki, Hirotsugu Kenmotsu, Hideyuki Harada, Yasuhisa Ohde, Yasutaka Chiba, Koji Haratani, Tamio Okimoto, Tomohiro Sakamoto, Kazushige Wakuda, Kentaro Ito, Takehiro Uemura, Shinya Sakata, Yoshihito Kogure, Yasumasa Nishimura, Kazuhiko Nakagawa and Nobuyuki Yamamoto

    Citation: BMC Cancer 2021 21:1121

    Content type: Study protocol

    Published on:

  8. We investigated the performance improvement of physicians with varying levels of chest radiology experience when using a commercially available artificial intelligence (AI)-based computer-assisted detection (C...

    Authors: Daiju Ueda, Akira Yamamoto, Akitoshi Shimazaki, Shannon Leigh Walston, Toshimasa Matsumoto, Nobuhiro Izumi, Takuma Tsukioka, Hiroaki Komatsu, Hidetoshi Inoue, Daijiro Kabata, Noritoshi Nishiyama and Yukio Miki

    Citation: BMC Cancer 2021 21:1120

    Content type: Research article

    Published on:

  9. Previous studies have observed a close association between hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC) as well as extrahepatic cancers. However, research concerning the effect of HBV i...

    Authors: Tong Liu, Wenqiang Li, Youcheng Zhang, Sarah Tan Siyin, Qi Zhang, Mengmeng Song, Kangping Zhang, Siqing Liu and Hanping Shi

    Citation: BMC Cancer 2021 21:1119

    Content type: Research article

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  10. Breast cancer chemoresistance is attributed to a wide variety of mechanisms, including autophagy. Transcription factor EB (TFEB) has been recently identified and characterized as one major regulator of autopha...

    Authors: Serena Bertozzi, Ambrogio P. Londero, Luigi Viola, Maria Orsaria, Michela Bulfoni, Stefania Marzinotto, Bruna Corradetti, Umberto Baccarani, Daniela Cesselli, Carla Cedolini and Laura Mariuzzi

    Citation: BMC Cancer 2021 21:1118

    Content type: Research article

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  11. Preoperative serum gamma-glutamyl transferase (γ-GT) levels is significantly related to the prognosis of hepatocellular carcinoma (HCC), but its clinical value in the management of postoperative adjuvant trans...

    Authors: Qiao Ke, Fu Xiang, Chunhong Xiao, Qizhen Huang, Xiaolong Liu, Yongyi Zeng, Lei Wang and Jingfeng Liu

    Citation: BMC Cancer 2021 21:1117

    Content type: Research article

    Published on:

  12. Abdominal computed tomography (CT) is the standard imaging method for patients with suspected colorectal liver metastases (CRLM) in the diagnostic workup for surgery or thermal ablation. Diffusion-weighted and...

    Authors: B. Görgec, I. Hansen, G. Kemmerich, T. Syversveen, M. Abu Hilal, E. J. T. Belt, R. H. C. Bisschops, T. L. Bollen, K. Bosscha, M. C. Burgmans, V. Cappendijk, M. T. De Boer, M. D’Hondt, B. Edwin, H. Gielkens, D. J. Grünhagen…

    Citation: BMC Cancer 2021 21:1116

    Content type: Study protocol

    Published on:

  13. Correct preoperative estimation of the malignant extent is crucial for optimal planning of breast cancer surgery. The sensitivity of mammography is lower in dense breasts, and additional imaging techniques are...

    Authors: Kristina Åhsberg, Anna Gardfjell, Emma Nimeus, Lisa Ryden and Sophia Zackrisson

    Citation: BMC Cancer 2021 21:1115

    Content type: Study protocol

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  14. Today, cancer ranks as one of the leading causes of death. Despite the large number of novel available therapies, radiotherapy (RT) remains as the most effective non-surgical method to cure cancer patients. In...

    Authors: Tomás Merino, Mauricio P. Pinto, María Paz Orellana, Gonzalo Martinez, Marcelo Andía, Pablo Munoz-Schuffenegger, Francisco Acevedo, Luigi Gabrielli, Cesar Sanchez and Jaime Pereira

    Citation: BMC Cancer 2021 21:1114

    Content type: Study protocol

    Published on:

  15. The outcome of patients with muscle-invasive bladder cancer (MIBC) remains poor, despite aggressive treatments. Inadequate primary staging, classically performed by computed tomography (CT)-imaging, could lead...

    Authors: Flor Verghote, Lindsay Poppe, Sofie Verbeke, Piet Dirix, Maarten Albersen, Gert De Meerleer, Charlien Berghen, Piet Ost, Geert Villeirs, Pieter De Visschere, Kathia De Man, Daan De Maeseneer, Sylvie Rottey, Charles Van Praet, Karel Decaestecker and Valérie Fonteyne

    Citation: BMC Cancer 2021 21:1113

    Content type: Study protocol

    Published on:

  16. Tumor cells exhibit enhanced metabolism of nutrients to satisfy the demand of sustained proliferation in vivo. Seminal reports have presented evidence that tryptophan (Trp) metabolic reprogramming induced by a...

    Authors: Fan Li, Zhenyu Zhao, Zongbiao Zhang, Yan Zhang and Wei Guan

    Citation: BMC Cancer 2021 21:1112

    Content type: Research

    Published on:

  17. Among patients with colorectal cancer (CRC) treated with oxaliplatin (L-OHP)-based chemotherapy, delayed chemotherapy-induced nausea and vomiting (CINV) have not been well controlled.

    Authors: Mototsugu Shimokawa, Toshinobu Hayashi, Junichi Nishimura, Taroh Satoh, Mutsumi Fukunaga, Reiko Matsui, Yasushi Tsuji, Fumitaka Mizuki and Takahiro Kogawa

    Citation: BMC Cancer 2021 21:1111

    Content type: Research

    Published on:

  18. As patients with cervical cancer and precancerous lesions can be diagnosed at early stage and live longer, it is imperative to understand their health-related quality of life so that better cancer-related poli...

    Authors: Min Zhao, Xin Pu, Yi Jun Yan, Shao Zhang, Xue Long, Lei Luo and Zheng Li

    Citation: BMC Cancer 2021 21:1110

    Content type: Research

    Published on:

  19. The effect of dairy products intake on breast cancer (BC) is highly controversial. This study aims to investigate the relationship between dairy intake and BC incidence.

    Authors: Yujing He, Qinghua Tao, Feifei Zhou, Yuexiu Si, Rongrong Fu, Binbin Xu, Jiaxuan Xu, Xiangyuan Li and Bangsheng Chen

    Citation: BMC Cancer 2021 21:1109

    Content type: Research

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  20. Diffuse gliomas are the most common malignant tumors of the central nervous system with poor treatment efficacy. Infiltration of immune cells into tumors during immunosurveillance is observed in multiple tumor...

    Authors: Constanze L. Kemmerer, Jens Schittenhelm, Evelyn Dubois, Laura Neumann, Lisa M. Häsler, Marius Lambert, Mirjam Renovanz, Stephan A. Kaeser, Ghazaleh Tabatabai, Ulf Ziemann, Ulrike Naumann and Markus C. Kowarik

    Citation: BMC Cancer 2021 21:1108

    Content type: Research article

    Published on:

  21. EGFR and ALK alternations often contribute to human malignancies, including lung cancer. EGFR and ALK mutations are usually sensitive to EGFR-tyrosine kinase inhibitors (TKIs) and ALK-TKIs. Although generally ...

    Authors: Xiaodan Yang, Jia Zhong, Zhuo Yu, Minglei Zhuo, Min Zhang, Rongrong Chen, Xuefeng Xia and Jun Zhao

    Citation: BMC Cancer 2021 21:1107

    Content type: Research article

    Published on:

  22. Body mass index (BMI), waist and hip circumference are strongly correlated and do not reflect body composition. A Body Shape Index (ABSI) and Hip Index (HI) define waist and hip size among individuals with the...

    Authors: Sofia Christakoudi, Konstantinos K. Tsilidis, Evangelos Evangelou and Elio Riboli

    Citation: BMC Cancer 2021 21:1106

    Content type: Research article

    Published on:

  23. The current standard treatment for elderly patients with newly diagnosed glioblastoma is surgery followed by short-course radiotherapy with temozolomide. In recent studies, 40 Gy in 15 fractions vs. 60 Gy in 3...

    Authors: Yoshiki Arakawa, Keita Sasaki, Yohei Mineharu, Megumi Uto, Takashi Mizowaki, Junki Mizusawa, Yuta Sekino, Tomohiro Ono, Hidefumi Aoyama, Kaishi Satomi, Koichi Ichimura, Manabu Kinoshita, Makoto Ohno, Yoshinori Ito, Ryo Nishikawa, Haruhiko Fukuda…

    Citation: BMC Cancer 2021 21:1105

    Content type: Study protocol

    Published on:

  24. While underlying mechanisms and pathways of social inequalities in cancer survival have been extensively examined in adults, this is less so for children with cancer. Hypothesized mechanisms include prediagnos...

    Authors: Line Hjøllund Pedersen, Friederike Erdmann, Gitte Lerche Aalborg, Lisa Lyngsie Hjalgrim, Hanne Bækgaard Larsen, Kjeld Schmiegelow, Jeanette Falck Winther and Susanne Oksbjerg Dalton

    Citation: BMC Cancer 2021 21:1104

    Content type: Research

    Published on:

  25. Low-level viremia generally refers to detectable HBV DNA levels lower than 2000 IU/mL. Studies show that low-level viremia is a risk factor for hepatocellular carcinoma. The aim of this study was to explore th...

    Authors: Furong Sun, Zhifei Liu and Bingyuan Wang

    Citation: BMC Cancer 2021 21:1103

    Content type: Research article

    Published on:

  26. Cervical cancer is the second commonly diagnosed cancer and the second leading cause of cancer death in women in Ethiopia, with rates among the highest worldwide. However, there are limited data on cervical ca...

    Authors: Biniyam Tefera Deressa, Mathewos Assefa, Ephrem Tafesse, Eva Johanna Kantelhardt, Ivan Soldatovic, Nikola Cihoric, Daniel Rauch and Ahmedin Jemal

    Citation: BMC Cancer 2021 21:1102

    Content type: Research

    Published on:

  27. Bortezomib (BZM), alone or in combination with other chemotherapies, has displayed strong anticancer effects in several cancers. The efficacy of the combination of BZM and mitoxantrone (MTX) in treating prosta...

    Authors: Ying Zhang, Qiuzi Liu, Wei Wei, Guoan Zhang, Siyuan Yan, Rongrong Dai, Ying Sun, Dubo Su, Shun Lv, Yong Xia, Jing Li and Changlin Li

    Citation: BMC Cancer 2021 21:1101

    Content type: Research

    Published on:

  28. Swallowing therapy is commonly provided as a treatment to lessen the risk or severity of dysphagia secondary to radiotherapy (RT) for head and neck cancer (HNC); however, best practice is not yet established. ...

    Authors: R. Martino, M. I. Fitch, C. D. Fuller, A. Hope, G. Krisciunas, S. E. Langmore, C. Lazarus, C. L. Macdonald, T. McCulloch, G. Mills, D. A. Palma, K. Pytynia, J. Ringash, K. Sultanem, J. Theurer, K. E. Thorpe…

    Citation: BMC Cancer 2021 21:1100

    Content type: Study protocol

    Published on:

  29. Implementing genetic testing for inherited cancer predisposition into routine clinical care offers a tremendous opportunity for cancer prevention and early detection. However, genetic testing itself does not i...

    Authors: Deborah Cragun, Jason Beckstead, Meagan Farmer, Gillian Hooker, Marleah Dean, Ellen Matloff, Sonya Reid, Ann Tezak, Anne Weidner, Jennifer G. Whisenant and Tuya Pal

    Citation: BMC Cancer 2021 21:1099

    Content type: Study protocol

    Published on:

  30. This study aimed to develop a reliable immune signature based on B-cell proportion to predict the prognosis and benefit of immunotherapy in LUAD.

    Authors: Yi Zhang, Xuewen Yin, Qi Wang, Xuming Song, Wenjie Xia, Qixing Mao, Bing Chen, Yingkuan Liang, Te Zhang, Lin Xu, Feng Jiang, Xinyu Xu and Gaochao Dong

    Citation: BMC Cancer 2021 21:1098

    Content type: Research

    Published on:

  31. Pancreatic cancer has highly aggressive features, such as local recurrence that leads to significantly high morbidity and mortality and recurrence after successful tumour resection. Intraoperative radiation th...

    Authors: Yun Sun Lee, Hyung Sun Kim, Yeona Cho, Ik Jae Lee, Hyo Jung Kim, Da Eun Lee, Hyeon Woong Kang and Joon Seong Park

    Citation: BMC Cancer 2021 21:1097

    Content type: Research

    Published on:

  32. Lung adenocarcinoma (LUAD) is the most prevalent non-small cell lung cancer (NSCLC). Patients with LUAD have a poor 5-year survival rate. The use of immune checkpoint inhibitors (ICIs) for the treatment of LUA...

    Authors: Weishuang Ma, Jiaming Liang, Junjian Mo, Siyuan Zhang, Ningdong Hu, Dongbo Tian and Zisheng Chen

    Citation: BMC Cancer 2021 21:1096

    Content type: Research article

    Published on:

  33. We aimed to analyze the clinicopathological features and outcomes of patients with gastric-type of HPV-independent endocervical adenocarcinoma (GAS HPVI ECA), and compare them with non-GAS HPVI ECA cases.

    Authors: Lili Chen, Yizhen Niu, Xiaoyun Wan, Lina Yu, Xiaofei Zhang, Amanda Louise Strickland, Liya Dong, Feng Zhou and Weiguo Lu

    Citation: BMC Cancer 2021 21:1095

    Content type: Research

    Published on:

  34. To ensure safe delivery of oncologic care during the COVID-19 pandemic, telemedicine has been rapidly adopted. However, little data exist on the impact of telemedicine on quality and accessibility of oncologic...

    Authors: Vivek Nimgaonkar, Charu Aggarwal, Abigail T. Berman, Peter Gabriel, Lawrence N. Shulman, John Kucharczuk, Megan Roy, Joshua M. Bauml, Aditi P. Singh, Roger B. Cohen, Corey J. Langer and Melina E. Marmarelis

    Citation: BMC Cancer 2021 21:1094

    Content type: Research article

    Published on:

  35. An underlying cause of solid tumor resistance to chemotherapy treatment is diminished tumor blood supply, which leads to a hypoxic microenvironment, dependence on anaerobic energy metabolism, and impaired deli...

    Authors: Amy A. Kirkham, Karen King, Anil A. Joy, André B. Pelletier, John R. Mackey, Kelvin Young, Xiaofu Zhu, Judith Meza-Junco, Sanraj K. Basi, Julie Price Hiller, Tina Brkin, Bonnie Michalowski, Edith Pituskin, D. Ian Paterson, Kerry S. Courneya, Richard B. Thompson…

    Citation: BMC Cancer 2021 21:1093

    Content type: Study protocol

    Published on:

  36. In oncology, liquid biopsy is of major relevance from theranostic point of view. The searching for mutations in circulating tumor DNA (ctDNA) in case of colorectal cancers (CRCs) allows the optimization of pat...

    Authors: Alexis Overs, Mylène Flammang, Eric Hervouet, Laurent Bermont, Jean-Luc Pretet, Borg Christophe and Zohair Selmani

    Citation: BMC Cancer 2021 21:1092

    Content type: Research

    Published on:

  37. Current opinions on whether surgical patients with cervical cancer should undergo para-aortic lymphadenectomy at the same time are inconsistent. The present study examined differences in survival outcomes with...

    Authors: Chunlin Chen, Hui Duan, Wenling Zhang, Hongwei Zhao, Li Wang, Shan Kang, Lihong Lin, Weidong Zhao, Yan Ni, Donglin Li, Jiaming Chen, Huijian Fan, Xiaolin Chen, Xiaonong Bin, Jinghe Lang and Ping Liu

    Citation: BMC Cancer 2021 21:1091

    Content type: Research

    Published on:

  38. Genetic alterations are common in non-small cell lung cancer (NSCLC), and DNA mutations and translocations are targets for therapy. Copy number aberrations occur frequently in NSCLC tumors and may influence ge...

    Authors: Maria Moksnes Bjaanæs, Gro Nilsen, Ann Rita Halvorsen, Hege G. Russnes, Steinar Solberg, Lars Jørgensen, Odd Terje Brustugun, Ole Christian Lingjærde and Åslaug Helland

    Citation: BMC Cancer 2021 21:1089

    Content type: Research

    Published on:

  39. The aminoisoquinoline FX-9 shows pro-apoptotic and antimitotic effects against lymphoblastic leukemia cells and prostate adenocarcinoma cells. In contrast, decreased cytotoxic effects against non-neoplastic bl...

    Authors: F. Weiner, J. T. Schille, D. Koczan, X.-F. Wu, M. Beller, C. Junghanss, M. Hewicker-Trautwein, H. Murua Escobar and I. Nolte

    Citation: BMC Cancer 2021 21:1088

    Content type: Research

    Published on:

  40. Cancer remains one of the leading causes of death worldwide, despite the possibilities to detect early onset of the most common cancer types. The search for the optimal therapy is complicated by the cancer div...

    Authors: Zane Simsone, Tālivaldis Freivalds, Dina Bēma, Indra Miķelsone, Liene Patetko, Juris Bērziņš, Līga Harju and Indulis Buiķis

    Citation: BMC Cancer 2021 21:1087

    Content type: Research

    Published on:

  41. Perioperative FLOT (5-fluorouracil, oxaliplatin and docetaxel) has recently become the gold standard treatment for fit patients with operable gastric (GC) or gastroesophageal (GEJ) adenocarcinoma, getting a 5-...

    Authors: Elisa Giommoni, Daniele Lavacchi, Giuseppe Tirino, Lorenzo Fornaro, Francesco Iachetta, Carmelo Pozzo, Maria Antonietta Satolli, Andrea Spallanzani, Marco Puzzoni, Silvia Stragliotto, Michele Sisani, Vincenzo Formica, Filippo Giovanardi, Antonia Strippoli, Michele Prisciandaro, Samantha Di Donato…

    Citation: BMC Cancer 2021 21:1086

    Content type: Research

    Published on:

  42. Circular RNAs (circRNAs) are implicated in the development of oral squamous cell carcinoma (OSCC). The aim of current research is to elucidate the role and mechanism of circ_0011946 in the functional behaviors...

    Authors: Ying Zhou, Shuhong Zhang, Zhonghan Min, Zhongwei Yu, Huaiwei Zhang and Jiao Jiao

    Citation: BMC Cancer 2021 21:1085

    Content type: Research article

    Published on:

  43. Little is known on the gender-specific effect and potential role of non-linear associations between metabolic syndrome (MetS) components and liver cancer risk. We evaluated these associations based on the UK B...

    Authors: Bin Xia, Jianjun Peng, De Toni Enrico, Kuiqing Lu, Eddie C. Cheung, Zichong Kuo, Qiangsheng He, Yan Tang, Anran Liu, Die Fan, Changhua Zhang, Yulong He, Yihang Pan and Jinqiu Yuan

    Citation: BMC Cancer 2021 21:1084

    Content type: Research

    Published on:

  44. The aim of the study was to estimate the minimally important difference (MID) for interpreting group-level change over time, both within a group and between groups, for the European Organisation for Research a...

    Authors: Eva M. Gamper, Jammbe Z. Musoro, Corneel Coens, Jean-Jacques Stelmes, Claudette Falato, Mogens Groenvold, Galina Velikova, Kim Cocks, Hans-Henning Flechtner, Madeleine T. King and Andrew Bottomley

    Citation: BMC Cancer 2021 21:1083

    Content type: Research article

    Published on:

  45. Alcohol consumption and smoking are the leading risk factors for laryngeal cancer (LC). Understanding the variations in disease burden of LC attributable to alcohol use and smoking is critical for LC prevention.

    Authors: Qiang-Wei Zhang, Jing-Yuan Wang, Xiao-Feng Qiao, Tong-Li Li and Xin Li

    Citation: BMC Cancer 2021 21:1082

    Content type: Research

    Published on:

  46. Text message-delivered interventions have potential to prevent weight regain and maintain diet and physical activity behaviours through extending contact with participants following initial weight loss, lifest...

    Authors: Jennifer R. Job, Elizabeth G. Eakin, Marina M. Reeves and Brianna S. Fjeldsoe

    Citation: BMC Cancer 2021 21:1081

    Content type: Research

    Published on:

  47. To compare the value of fluorodeoxyglucose positron emission tomography (FDG-PET)/computed tomography (CT) and magnetic resonance imaging (MRI) in differentiating benign and malignant ovarian or adnexal tumors.

    Authors: Xianwen Hu, Dandan Li, Zhigang Liang, Yan Liao, Ling Yang, Rui Wang, Pan Wang and Jiong Cai

    Citation: BMC Cancer 2021 21:1080

    Content type: Research

    Published on:

  48. Activation of the oncogene yes-associated protein (YAP) is frequently detected in intrahepatic cholangiocarcinoma (iCCA); however, the expression pattern and the functional impact of its paralogue WW domain-conta...

    Authors: Marcell Tóth, Lilija Wehling, Lena Thiess, Fabian Rose, Jennifer Schmitt, Sofia M. E. Weiler, Carsten Sticht, Carolina De La Torre, Melina Rausch, Thomas Albrecht, Niels Grabe, Lea Duwe, Jesper B. Andersen, Bruno C. Köhler, Christoph Springfeld, Arianeb Mehrabi…

    Citation: BMC Cancer 2021 21:1079

    Content type: Research

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  49. Cervical cancer is a common malignancy of the female genital tract. Treatment options for cervical cancer patients diagnosed at FIGO (2009) stage IB2 and IIA2 remains controversial.

    Authors: Jing Cheng, Beibei Liu, Biao Wang, Xicui Long, Zhihong Li, Ruili Chen, Ruiting Wu and Lin Xu

    Citation: BMC Cancer 2021 21:1078

    Content type: Research

    Published on:

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