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  1. Majority of neuroblastoma patients develop metastatic disease at diagnosis and their prognosis is poor with current therapeutic approach. Major challenges are how to tackle the mechanisms responsible for tumor...

    Authors: Jiao-Le Yu, Shing Chan, Marcus Kwong-Lam Fung and Godfrey Chi-Fung Chan

    Citation: BMC Cancer 2021 21:393

    Content type: Research article

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  2. The 37 kDa/67 kDa laminin receptor (LRP/LR) is involved in several tumourigenic-promoting processes including cellular viability maintenance and apoptotic evasion. Thus, the aim of this study was to assess the...

    Authors: Leila Vania, Gavin Morris, Eloise Ferreira and Stefan F. T. Weiss

    Citation: BMC Cancer 2021 21:392

    Content type: Research article

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  3. Astrocytoma is a common type of central nervous system tumor. In this study, we investigated the correlation between ST6GAL1 and CYP19A1 polymorphisms and the risk and prognosis of astrocytoma.

    Authors: Tuo Wang, Yao Sun, Zichao Xiong, Jiamin Wu, Xiaoying Ding, Xiaoye Guo and Yuan Shao

    Citation: BMC Cancer 2021 21:391

    Content type: Research article

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  4. Definitive diagnosis of peripheral pulmonary lesions (PPLs) depends on the histological analysis of the pleural biopsy sample. Ultrasound (US)-guided sampling is now standard practice in the clinical setting. ...

    Authors: Weijun Huang, Jieyi Ye, Yide Qiu, Weiwei Peng, Ninghui Lan, Weizhen Cui, Ting Huang, Yinghui Ou and Yingjia Li

    Citation: BMC Cancer 2021 21:390

    Content type: Research article

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  5. Synonymous mutations do not change the protein sequences. Automatically, they have been regarded as neutral events and are ignored in the mutation-based cancer studies. However, synonymous mutations will chang...

    Authors: Qun Li, Jian Li, Chun-peng Yu, Shuai Chang, Ling-ling Xie and Song Wang

    Citation: BMC Cancer 2021 21:388

    Content type: Research article

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  6. Cancer patients with brain metastases (BMs) require multidisciplinary care, and treatment facility may play a role. This study aimed to investigate the impact of receiving treatment at academic centers on the ...

    Authors: Saber Amin, Michael Baine, Jane Meza and Chi Lin

    Citation: BMC Cancer 2021 21:387

    Content type: Research article

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  7. Gliomas are often associated with symptoms including seizures. Most patients with high-grade gliomas are treated with radiotherapy or radio-chemotherapy. Since irradiation causes inflammation, it may initially...

    Authors: Dirk Rades, Jaspar Witteler, Denise Olbrich, Peter Trillenberg, Steven E. Schild, Soeren Tvilsted and Troels W. Kjaer

    Citation: BMC Cancer 2021 21:386

    Content type: Study protocol

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  8. Herein, we investigate the relationship between pancreatic stem cell markers (PCSC markers), CD44, and epithelial-specific antigen (ESA), tumor stroma, and the impact on recurrence outcomes in pancreatic ducta...

    Authors: Gokce Askan, Ibrahim Halil. Sahin, Joanne F. Chou, Aslihan Yavas, Marinela Capanu, Christine A. Iacobuzio-Donahue, Olca Basturk and Eileen M. O’Reilly

    Citation: BMC Cancer 2021 21:385

    Content type: Research article

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  9. The dose perturbation effect of immobilization devices is often overlooked in intensity-modulated radiation therapy (IMRT) for breast cancer (BC). This retrospective study assessed the dosimetric effects of su...

    Authors: Ran Lv, Guangyi Yang, Yongzhi Huang and Yanhong Wang

    Citation: BMC Cancer 2021 21:384

    Content type: Research article

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  10. Pancreatic ductal adenocarcinoma (PDAC) is a leading causes of cancer mortality worldwide. Currently, laparoscopic pancreatic resection (LPR) is extensively applied to treat benign and low-grade diseases relat...

    Authors: Ke Chen, Yu Pan, Chao-jie Huang, Qi-long Chen, Ren-chao Zhang, Miao-zun Zhang, Guan-yu Wang, Xian-fa Wang, Yi-ping Mou and Jia-fei Yan

    Citation: BMC Cancer 2021 21:382

    Content type: Research article

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  11. The role of glycolysis in tumorigenesis has received increasing attention and multiple glycolysis-related genes (GRGs) have been proven to be associated with tumor metastasis. Hence, we aimed to construct a pr...

    Authors: Qianwei Xing, Tengyue Zeng, Shouyong Liu, Hong Cheng, Limin Ma and Yi Wang

    Citation: BMC Cancer 2021 21:381

    Content type: Research article

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  12. Identifying gene mutation signatures will enable a better understanding for the occurrence and development of colorectal cancer (CRC), and provide some potential biomarkers for clinical practice. Currently, ho...

    Authors: Yan Zhuang, Hailong Wang, Da Jiang, Ying Li, Lixia Feng, Caijuan Tian, Mingyu Pu, Xiaowei Wang, Jiangyan Zhang, Yuanjing Hu and Pengfei Liu

    Citation: BMC Cancer 2021 21:380

    Content type: Research article

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  13. Immunotherapy is a vital component in cancer treatment. However, due to the complex genetic bases of cancer, a clear prediction index for efficacy has not been established. Tumor mutation burden (TMB) is one o...

    Authors: Liwei Wang, Fu Chen, Rui Liu, Lei Shi, Guosheng Zhao and Zhengjian Yan

    Citation: BMC Cancer 2021 21:379

    Content type: Research article

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  14. Despite improvements in median survival some patients with advanced ovarian cancer die within 100 days of diagnosis; the reasons for which remain poorly understood.

    Authors: Amy Hawarden, Bryn Russell, Mary Ellen Gee, Fatima Skayali, Andrew Clamp, Emma Jayne Crosbie and Richard John Edmondson

    Citation: BMC Cancer 2021 21:378

    Content type: Research article

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  15. Epiplakin1 (Eppk1) is part of epidermal growth factor (EGF) signal and takes part in reorganization of cytoskeleton and cell proliferation. However, the role of Eppk1 in cervical cancer (CC) remains unknown.

    Authors: Dong Ma, Zhe Pan, Quan Chang, Jin-jin Zhang, Xiao Liu, Na Hua and Guo-Hua Li

    Citation: BMC Cancer 2021 21:377

    Content type: Research article

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  16. Studies suggest that mutations in the CTNNB1 gene are predictive of response to immunotherapy, an emerging therapy for advanced hepatocellular carcinoma (HCC). Analysis of circulating tumor DNA (ctDNA) offers the...

    Authors: Stine Karlsen Oversoe, Michelle Simone Clement, Britta Weber, Henning Grønbæk, Stephen Jacques Hamilton-Dutoit, Boe Sandahl Sorensen and Jens Kelsen

    Citation: BMC Cancer 2021 21:376

    Content type: Research article

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  17. Pulmonary metastasectomy (PM) is an established treatment for selected patients with metastatic sarcomas. The aim of this study was to examine our institutional experience and evaluate factors predicting outcome.

    Authors: Theresa Stork, Rebecca Boemans, Jendrik Hardes, Arne Streitbürger, Uta Dirksen, Christoph Pöttgen, Hans-Ulrich Schildhaus, Sebastian Bauer, Stéphane Collaud and Clemens Aigner

    Citation: BMC Cancer 2021 21:375

    Content type: Research article

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  18. Successful breast cancer screening relies on timely follow-up of abnormal mammograms. Delayed or failure to follow-up abnormal mammograms undermines the potential benefits of screening and is associated with p...

    Authors: Jeanette C. Reece, Eleanor F. G. Neal, Peter Nguyen, Jennifer G. McIntosh and Jon D. Emery

    Citation: BMC Cancer 2021 21:373

    Content type: Research article

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  19. Oral squamous cell carcinoma (OSCC) is the dominant histologic type of oral cancer. Locally advanced OSCC remains a major therapeutic challenge. Our study aimed to develop and validate nomograms predicting sur...

    Authors: Zhiliang Nie, Pengcheng Zhao, Yishan Shang and Bo Sun

    Citation: BMC Cancer 2021 21:372

    Content type: Research article

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  20. Nodular (NM) and superficial spreading melanoma (SSM) show different disease trajectories, with more rapid development in NM and fewer opportunities for early detection often resulting in worse outcomes. Our s...

    Authors: Adina Coroiu, Chelsea Moran, Jessica A. Davine, Kyla Brophy, Catherine Bergeron, Hensin Tsao, Annett Körner, Susan M. Swetter and Alan C. Geller

    Citation: BMC Cancer 2021 21:371

    Content type: Research article

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  21. The abundance of immune and stromal cells in the tumor microenvironment (TME) is informative of levels of inflammation, angiogenesis, and desmoplasia. Radiomics, an approach of extracting quantitative features...

    Authors: Dooman Arefan, Ryan M. Hausler, Jules H. Sumkin, Min Sun and Shandong Wu

    Citation: BMC Cancer 2021 21:370

    Content type: Research article

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  22. Germline RET mutations and variants are involved in development of multiple endocrine neoplasia type 2 (MEN2). The present study investigated a spectrum of RET variants, analyzed genotype-phenotype relationships,...

    Authors: Xiao-Ping Qi, Jian-Qiang Zhao, Xu-Dong Fang, Bi-Jun Lian, Feng Li, Hui-Hong Wang, Zhi-Lie Cao, Wei-Hui Zheng, Juan Cao and Yu Chen

    Citation: BMC Cancer 2021 21:369

    Content type: Research article

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  23. An important mechanism that promoter methylation-mediated gene silencing for gene inactivation is identified in human tumorigenesis. Methylated genes have been found in breast cancer (BC) and beneficial biomar...

    Authors: Zhao Liu, Jiaxin Liu, Ruimiao Liu, Man Xue, Weifan Zhang, Xinhui Zhao, Jiang Zhu and Peng Xia

    Citation: BMC Cancer 2021 21:367

    Content type: Research article

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  24. Given their widespread availability and relatively low cost, percutaneous thermal ablation is commonly performed under the guidance of computed tomography (CT) or ultrasound (US). However, such imaging modalit...

    Authors: Zhaonan Li, Chaoyan Wang, Guangyan Si, Xueliang Zhou, Yahua Li, Jing Li, Dechao Jiao and Xinwei Han

    Citation: BMC Cancer 2021 21:366

    Content type: Research article

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  25. An estimated 40% of cancer cases in the UK in 2015 were attributable to cancer risk behaviours. Tobacco smoking, alcohol consumption, obesity, and unprotected sexual intercourse are known causes of cancer and ...

    Authors: Caroline Wright, Jon Heron, Ruth Kipping, Matthew Hickman, Rona Campbell and Richard M. Martin

    Citation: BMC Cancer 2021 21:365

    Content type: Research article

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  26. The intimate relationship between coagulation and fibrinolysis in malignant tumors is a well-known phenomena, with the malignant phenotype enhancing coagulation and fibrinolysis. We hypothesized that soft tiss...

    Authors: Kunihiro Asanuma, Tomoki Nakamura, Tomohito Hagi, Takayuki Okamoto, Kouji Kita, Koichi Nakamura, Yumi Matsuyama, Keisuke Yoshida, Yumiko Asanuma and Akihiro Sudo

    Citation: BMC Cancer 2021 21:364

    Content type: Research article

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  27. Next generation sequencing (NGS) has been a handy tool in clinical practice, mainly due to its efficiency and cost-effectiveness. It has been widely used in genetic diagnosis of several inherited diseases, and...

    Authors: Amanda Ferreira Vidal, Rafaella Sousa Ferraz, Antonette El-Husny, Caio Santos Silva, Tatiana Vinasco-Sandoval, Leandro Magalhães, Milene Raiol-Moraes, Williams Fernandes Barra, Cynthia Lara Brito Lins Pereira, Paulo Pimentel de Assumpção, Leonardo Miranda de Brito, Ricardo Assunção Vialle, Sidney Santos, Ândrea Ribeiro-dos-Santos and André M. Ribeiro-dos-Santos

    Citation: BMC Cancer 2021 21:363

    Content type: Research article

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  28. Hand-foot syndrome (HFS) is a side effect of skin related to pegylated liposomal doxorubicin (PLD) application. Moderate to severe hand-foot syndrome (MSHFS) might have a serious impact on patients’ quality of...

    Authors: Guohua Liang, Wenjie Ma, Yanfang Zhao, Eryu Liu, Xiaoyu Shan, Weiwei Ma, Dabei Tang, Liru Li, Xingjian Niu, Wenhui Zhao and Qingyuan Zhang

    Citation: BMC Cancer 2021 21:362

    Content type: Research article

    Published on:

  29. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Chen-Chen Huang, Fang-Rui Liu, Qiang Feng, Xin-Yan Pan, Shu-Ling Song and Ju-Lun Yang

    Citation: BMC Cancer 2021 21:361

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2021 21:321

  30. The rate of toxic deaths related to induction chemotherapy in the treatment of locally advanced head and neck cancers is unacceptable and calls into question this therapeutic strategy, which is however highly ...

    Authors: Maureen Bernadach, Michel Lapeyre, Anne-Françoise Dillies, Jessica Miroir, Melanie Casile, Juliette Moreau, Ioana Molnar, Angeline Ginzac, Nathalie Pham-Dang, Nicolas Saroul, Xavier Durando and Julian Biau

    Citation: BMC Cancer 2021 21:360

    Content type: Research article

    Published on:

  31. Colorectal cancer (CRC) remains a serious health concern worldwide. Despite advances in diagnosis and treatment, about 15 to 30% of stage II CRC patients subjected to tumor resection with curative intent, deve...

    Authors: Sara Ribeirinho-Soares, Diana Pádua, Ana Luísa Amaral, Elvia Valentini, Daniela Azevedo, Cristiana Marques, Rita Barros, Filipa Macedo, Patrícia Mesquita and Raquel Almeida

    Citation: BMC Cancer 2021 21:359

    Content type: Research article

    Published on:

  32. A classification tree was used to analyze background factors for granulocyte colony-stimulating factor (G-CSF) preparation selection for febrile neutropenia (FN) prophylaxis in Japanese patients with non-Hodgk...

    Authors: Masahiro Yokoyama, Yoshiharu Kusano, Norihito Inoue, Noriko Nishimura, Yuko Mishima, Tomoyuki Nukada, Kiyohiko Hatake and Yasuhito Terui

    Citation: BMC Cancer 2021 21:358

    Content type: Research article

    Published on:

  33. The expression of immune checkpoint receptors (ICRs) on tumor-infiltrating lymphocytes (TILs) is associated with better response to immunotherapies via immune checkpoint inhibitors. Therefore, we investigated ...

    Authors: Neslihan Cabioglu, Semen Onder, Gizem Oner, Hüseyin Karatay, Mustafa Tukenmez, Mahmut Muslumanoglu, Abdullah İgci, Yeşim Eralp, Adnan Aydiner, Pınar Saip, Ekrem Yavuz and Vahit Ozmen

    Citation: BMC Cancer 2021 21:357

    Content type: Research article

    Published on:

  34. Evidence bearing on the role of statins in the prevention and treatment of cancer is confounded by the diversity of statins, chemotherapeutic agents and cancer types included in the numerous published studies;...

    Authors: Kaitlyn A. Khandelwal Gilman, Seungmin Han, Young-Wook Won and Charles W. Putnam

    Citation: BMC Cancer 2021 21:356

    Content type: Research article

    Published on:

  35. The long non-coding (lnc) RNA activated by small nucleolar RNA host gene 16 (SNHG16), which has been reported to play a vital role in a number of different types of cancer, is a novel lncRNA. However, followin...

    Authors: Xiao Xiao, Ge Jiang, Shengtao Zhang, Shuo Hu, Yunshan Fan, Gang Li, Haiyang Yu and Shisheng He

    Citation: BMC Cancer 2021 21:355

    Content type: Research article

    Published on:

  36. Patients with metastatic colorectal cancer are treated with cytotoxic chemotherapy supplemented by molecularly targeted therapies. There is a critical need to define biomarkers that can optimise the use of the...

    Authors: Reem D. Mahmood, Danielle Shaw, Tine Descamps, Cong Zhou, Robert D. Morgan, Saifee Mullamitha, Mark Saunders, Nerissa Mescallado, Alison Backen, Karen Morris, Ross A. Little, Susan Cheung, Yvonne Watson, James P. B. O’Connor, Alan Jackson, Geoff J. M. Parker…

    Citation: BMC Cancer 2021 21:354

    Content type: Research article

    Published on:

  37. Numerous studies have reported the correlation between AXIN2 polymorphism and cancer risk, but the results seem not consistent. In order to get an overall, accurate and updated results about AXIN2 polymorphism an...

    Authors: Xi Li, Yiming Li, Guodong Liu and Wei Wu

    Citation: BMC Cancer 2021 21:353

    Content type: Research article

    Published on:

  38. Lung cancer survivors need more options to improve quality of life (QoL). It is unclear to what extent patients with advanced stage disease are willing to participate in home-based physical activity (PA) and i...

    Authors: Brett C. Bade, Geliang Gan, Fangyong Li, Lingeng Lu, Lynn Tanoue, Gerard A. Silvestri and Melinda L. Irwin

    Citation: BMC Cancer 2021 21:352

    Content type: Research article

    Published on:

  39. Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is an uncommon variant of Hodgkin lymphoma. There is limited data on treatment, management of refractory and relapsed disease, and long-term outcome. Man...

    Authors: Saad Akhtar, M. Shahzad Rauf, Yasser Khafaga, Amani Al-Kofide, Tusneem Ahmed M. Elhassan, Mahmoud A. Elshenawy, Juzer Nadri, Ali Hassan Mushtaq, Nasir Bakshi, Mohammed Shamayel, Suleiman Al-Sweedan, Sohail Sarwar and Irfan Maghfoor

    Citation: BMC Cancer 2021 21:351

    Content type: Research article

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  40. The World Health Organisation (WHO) calls for the elimination of cervical cancer (CC) as a public health issue. To achieve elimination, efforts must be aligned and accelerated. Women living with HIV (WLWH) hav...

    Authors: Anna Tisler, Sven Erik Ojavee, Piret Veerus, Pilleriin Soodla and Anneli Uusküla

    Citation: BMC Cancer 2021 21:350

    Content type: Research article

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  41. Immunotherapy has been recently established as a new direction for the treatment of colorectal cancer (CRC), a gastrointestinal cancer. In this investigation, we aimed to expound how the posttranscriptional re...

    Authors: Shiquan Li, Guoqiang Yan, Meng Yue and Lei Wang

    Citation: BMC Cancer 2021 21:349

    Content type: Research article

    Published on:

  42. Angiogenesis assessment is important for personalized therapeutic intervention in patients with non-small-cell lung cancer (NSCLC). This study investigated whether radiologic parameters obtained by dynamic con...

    Authors: Yu-Sen Huang, Jenny Ling-Yu Chen, Hsin-Ming Chen, Li-Hao Yeh, Jin-Yuan Shih, Ruoh-Fang Yen and Yeun-Chung Chang

    Citation: BMC Cancer 2021 21:348

    Content type: Research article

    Published on:

  43. The survival rate after childhood cancer has improved to 80%. The majority of childhood cancer survivors (CCS) will experience late complications which require follow up care, including access to their individ...

    Authors: Helena M. Linge and Cecilia Follin

    Citation: BMC Cancer 2021 21:347

    Content type: Research article

    Published on:

  44. Despite the wide-spread use of immune checkpoint inhibitors (ICIs) in cancer chemotherapy, reports on patients developing acquired resistance (AR) to ICI therapy are scarce. Therefore, we first investigated th...

    Authors: Kazutaka Hosoya, Daichi Fujimoto, Takeshi Morimoto, Toru Kumagai, Akihiro Tamiya, Yoshihiko Taniguchi, Toshihide Yokoyama, Tadashi Ishida, Hirotaka Matsumoto, Katsuya Hirano, Ryota Kominami, Keisuke Tomii, Hidekazu Suzuki, Tomonori Hirashima, Satoshi Tanaka, Junji Uchida…

    Citation: BMC Cancer 2021 21:346

    Content type: Research article

    Published on:

  45. The essence of energy metabolism has spread to the field of esophageal cancer (ESC) cells. Herein, we tried to develop a prognostic prediction model for patients with ESC based on the expression profiles of en...

    Authors: Weifeng Zheng, Chaoying Chen, Jianghao Yu, Chengfeng Jin and Tiemei Han

    Citation: BMC Cancer 2021 21:345

    Content type: Research article

    Published on:

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