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  1. Content type: Research article

    Lung adenocarcinoma is the most common type of lung cancers. Whole-genome sequencing studies disclosed the genomic landscape of lung adenocarcinomas. however, it remains unclear if the genetic alternations cou...

    Authors: Jiaxian Yu, Yueming Hu, Yafei Xu, Jue Wang, Jiajie Kuang, Wei Zhang, Jianlin Shao, Dianjing Guo and Yejun Wang

    Citation: BMC Cancer 2019 19:263

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  2. Content type: Research article

    Epithelial-mesenchymal transition (EMT) may be one of the reasons for the failure in some clinical trials regarding histone deacetylase inhibitors (HDACIs)-treated solid tumors. We investigated the effects of ...

    Authors: Zhihua Shen, Xiaomin Liao, Zhongming Shao, Muyin Feng, Jianling Yuan, Sisi Wang, Siyuan Gan, Yanping Ha, Zhiwei He and Wei Jie

    Citation: BMC Cancer 2019 19:262

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  3. Content type: Research article

    The immune system is a crucial component in cancer progression or regression. Molecular iodine (I2) exerts significant antineoplastic effects, acting as a differentiation inductor and immune modulator, but its ef...

    Authors: Irasema Mendieta, Rosa E. Nuñez-Anita, Mario Nava-Villalba, Xóchitl Zambrano-Estrada, Evangelina Delgado-González, Brenda Anguiano and Carmen Aceves

    Citation: BMC Cancer 2019 19:261

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  4. Content type: Correction

    Following publication of the original article [1], the author noticed that there are some errors with Table 1 and Table 2. Please see the correct tables below. The authors apologize for any inconvenience caused.

    Authors: Cong Hua, Gang Zhao, Yunqian Li and Li Bie

    Citation: BMC Cancer 2019 19:260

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    The original article was published in BMC Cancer 2014 14:526

  5. Content type: Research article

    Though the management of malignancies has improved vastly in recent years, many treatment options lack the desired efficacy and fail to adequately augment patient morbidity and mortality. It is increasingly cl...

    Authors: Andrew Riley, Victoria Green, Ramsah Cheah, Gordon McKenzie, Laszlo Karsai, James England and John Greenman

    Citation: BMC Cancer 2019 19:259

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  6. Content type: Research article

    The oncoprotein MYC has the dual capacity to drive cell cycle progression or induce apoptosis, depending on the cellular context. BAG1 was previously identified as a transcriptional target of MYC that function...

    Authors: Victoria J. Gennaro, Helen Wedegaertner and Steven B. McMahon

    Citation: BMC Cancer 2019 19:258

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  7. Content type: Correction

    Following publication of the original article [1], the author noticed the following errors in the article.

    Authors: Wenxing Chen, Yanhong Pan, Siliang Wang, Yuping Liu, Guangying Chen, Liang Zhou, Chao Zhang, Wenting Ni, Aiyun Wang, Yin Lu and Shile Huang

    Citation: BMC Cancer 2019 19:257

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    The original article was published in BMC Cancer 2017 17:34

  8. Content type: Research article

    To systematically assess the prevalence of BRCA1 and BRCA2 gene mutations in women with Hereditary Breast and/or Ovarian Cancer (HBOC) in Arab countries and to describe the variability in the BRCA gene mutatio...

    Authors: Khadiga Abdulrashid, Nour AlHussaini, Wifag Ahmed and Lukman Thalib

    Citation: BMC Cancer 2019 19:256

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  9. Content type: Research article

    In the era of genome-guided personalized cancer treatment, we must understand chemotherapy-induced genomic changes in tumors. This study evaluated whether adjuvant FOLFOX chemotherapy modifies the mutational p...

    Authors: Kazuaki Harada, Wataru Okamoto, Sachiyo Mimaki, Yasuyuki Kawamoto, Hideaki Bando, Riu Yamashita, Satoshi Yuki, Takayuki Yoshino, Yoshito Komatsu, Atsushi Ohtsu, Naoya Sakamoto and Katsuya Tsuchihara

    Citation: BMC Cancer 2019 19:255

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  10. Content type: Study protocol

    Approximately 20–30% of patients with pT4 colon cancer develop metachronous peritoneal metastases (PM). Due to restricted accuracy of imaging modalities and absence of early symptoms, PM are often detected at ...

    Authors: Vivian P. Bastiaenen, Charlotte E. L. Klaver, Niels F. M. Kok, Johannes H. W. de Wilt, Ignace H. J. T. de Hingh, Arend G. J. Aalbers, Djamila Boerma, Andre J. A. Bremers, Jacobus W. A. Burger, Eino B. van Duyn, Pauline Evers, Wilhelmina M. U. van Grevenstein, Patrick H. J. Hemmer, Eva V. E. Madsen, Petur Snaebjornsson, Jurriaan B. Tuynman…

    Citation: BMC Cancer 2019 19:254

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  11. Content type: Research article

    Despite its relatively low incidence, pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer deaths because of the aggressive growth/metastasis of the tumor, the lack of early symptoms, and the p...

    Authors: Jesse Bakke, William C. Wright, Anthony E. Zamora, Peter Oladimeji, Jeremy Chase Crawford, Christopher T. Brewer, Robert J. Autry, William E. Evans, Paul G. Thomas and Taosheng Chen

    Citation: BMC Cancer 2019 19:253

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  12. Content type: Research article

    Carbohydrate antigen (CA) 19–9 levels after resection are considered to predict prognosis; however, the significance of decreased CA19–9 levels after neoadjuvant therapy has not been clarified. This study aime...

    Authors: Shuichi Aoki, Fuyuhiko Motoi, Yoshiaki Murakami, Masayuki Sho, Sohei Satoi, Goro Honda, Kenichiro Uemura, Ken-ichi Okada, Ippei Matsumoto, Minako Nagai, Hiroaki Yanagimoto, Masanao Kurata, Takumi Fukumoto, Masamichi Mizuma, Hiroki Yamaue and Michiaki Unno

    Citation: BMC Cancer 2019 19:252

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  13. Content type: Research article

    Dexamethasone is widely used in cancer patients despite the concern that perioperative glucocorticoids may potentially cause immunosuppression. However, studies on the influence of dexamethasone on cancer recu...

    Authors: Myoung Hwa Kim, Dong Wook Kim, Seho Park, Joo Heung Kim, Ki Young Lee, Jisung Hwang and Young Chul Yoo

    Citation: BMC Cancer 2019 19:251

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  14. Content type: Research article

    Although men carry a higher risk of hepatocellular carcinoma (HCC) than women, it is still controversial whether men also have a poorer postoperative prognosis. A retrospective study was conducted to evaluate ...

    Authors: Ming-Wei Lai, Yu-De Chu, Chih-Lang Lin, Rong-Nan Chien, Ta-Sen Yeh, Tai-Long Pan, Po-Yuan Ke, Kwang-Hui Lin and Chau-Ting Yeh

    Citation: BMC Cancer 2019 19:250

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  15. Content type: Research article

    CanAssist-Breast is an immunohistochemistry based test that predicts risk of distant recurrence in early-stage hormone receptor positive breast cancer patients within first five years of diagnosis. Immunohisto...

    Authors: Arun Kumar Attuluri, Chandra Prakash V. Serkad, Aparna Gunda, Charusheila Ramkumar, Chetana Basavaraj, Ljubomir Buturovic, Lekshmi Madhav, Nirupama Naidu, Naveen Krishnamurthy, R. Prathima, Suchita Kanaldekar and Manjiri M. Bakre

    Citation: BMC Cancer 2019 19:249

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  16. Content type: Research article

    Garlic has been used for centuries for its flavour and health promoting properties that include protection against cancer. The vinyl disulfide-sulfoxide ajoene is one of the phytochemicals found in crushed clo...

    Authors: Catherine H. Kaschula, Rosanna Tuveri, Ellen Ngarande, Kevin Dzobo, Christopher Barnett, Daniel A. Kusza, Lisa M. Graham, Arieh A. Katz, Mohamed Suhail Rafudeen, M. Iqbal Parker, Roger Hunter and Georgia Schäfer

    Citation: BMC Cancer 2019 19:248

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  17. Content type: Research article

    Swainsonine is a natural indolizidine alkaloid, its anti-tumor activity has been widely reported in varied cancers. This study aimed to investigate whether Swainsonine exerted anti-tumor impact on glioma cells...

    Authors: Libo Sun, Xingyi Jin, Lijuan Xie, Guangjun Xu, Yunxia Cui and Zhuo Chen

    Citation: BMC Cancer 2019 19:247

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  18. Content type: Research article

    Docetaxel is a widely used cytotoxic agent for treatments of various cancers. The ATP binding cassette (ABC) transporter / multidrug resistance protein (MRP) ABCC10/MRP7, involved in transporting taxanes, has ...

    Authors: Kazuki Sone, Tetsuya Oguri, Takehiro Uemura, Akira Takeuchi, Satoshi Fukuda, Osamu Takakuwa, Ken Maeno, Kensuke Fukumitsu, Yoshihiro Kanemitsu, Hirotsugu Ohkubo, Masaya Takemura, Yutaka Ito and Akio Niimi

    Citation: BMC Cancer 2019 19:246

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  19. Content type: Research article

    Fine-needle aspiration (FNA) is the most reliable method for diagnosing thyroid nodules; however, some features such as atypia of undetermined significance or follicular lesion of undetermined significance can...

    Authors: Masanori Teshima, Kazuya Tokita, Eijitsu Ryo, Fumihiko Matsumoto, Madoka Kondo, Yota Ikegami, Hirotaka Shinomiya, Naoki Otsuki, Nobuyoshi Hiraoka, Ken-ichi Nibu, Seiichi Yoshimoto and Taisuke Mori

    Citation: BMC Cancer 2019 19:245

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  20. Content type: Case report

    Nonseminomatous germ cell tumors (NSGCTs) represent one of the main groups of germ cell tumors (GCTs), and they have a more invasive course than seminomatous GCTs. Human immunodeficiency virus (HIV) positivity...

    Authors: Ruili Li and Hongjun Li

    Citation: BMC Cancer 2019 19:244

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  21. Content type: Research article

    High-risk neuroblastoma with N-Myc amplification remains a therapeutic challenge in paediatric oncology. Antagonism of pro-death Bcl-2 homology (BH) proteins to pro-survival BH members such as Mcl-1 and Bcl-2 ...

    Authors: Stefanie Klenke, Neval Akdeli, Patrick Stelmach, Lukas Heukamp, Johannes H. Schulte and Hagen S. Bachmann

    Citation: BMC Cancer 2019 19:243

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  22. Content type: Case report

    Patients with relapsed/refractory acute myeloid leukemia after hematopoietic stem cell transplantation (HSCT) have a poor prognosis, with a 2-year survival rate of 14%. The optimal treatment for these patients...

    Authors: Mengqi Jin, Yongxian Hu, Wenjun Wu, Yi Luo, Yamin Tan, Jian Yu, Aiyun Jin, Luxin Yang, He Huang and Guoqing Wei

    Citation: BMC Cancer 2019 19:242

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  23. Content type: Research article

    Growing evidence indicates that inflammation contributes to cancer progression, and several inflammatory markers have been reported to be associated with the clinical outcomes in patients with various types of...

    Authors: Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shinji Matsutani, Kenjiro Kimura, Ryosuke Amano, Kosei Hirakawa and Masaichi Ohira

    Citation: BMC Cancer 2019 19:241

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  24. Content type: Research article

    Since Mesenchymal epithelial transition (MET) amplification has been regarded as a potential treatment target, the knowledge of its prevalence and prognostic importance is crucial. However, its clinical pathologi...

    Authors: Yanqiu Wang, Zhengzeng Jiang, Chen Xu, Hao Wang, Lijie Tan, Jieakesu Su, Xin Wang, Dongxian Jiang, Yingyong Hou and Qi Song

    Citation: BMC Cancer 2019 19:240

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  25. Content type: Research article

    Cancer indicators are essential information for cancer surveillance and cancer research strategy development. The Martinique Cancer Registry (MCR) is a population-based cancer Registry (PBCR) that has been rec...

    Authors: Clarisse Joachim, Jacqueline Veronique-Baudin, Stephen Ulric-Gervaise, Audrey Pomier, Aimée Pierre-Louis, Mylène Vestris, Jean-Luc Novella, Moustapha Drame, Jonathan Macni and Patrick Escarmant

    Citation: BMC Cancer 2019 19:239

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  26. Content type: Research article

    The purpose of the present study was to characterize the prevalence, associated factors, and to construct a nomogram for predicting bone metastasis (BM) with different histological types of lung cancer.

    Authors: Chao Zhang, Min Mao, Xu Guo, Ping Cui, Lianmin Zhang, Yao Xu, Lili Li, Xiuxin Han, Karl Peltzer, Shunbin Xiong, Vladimir P. Baklaushev, Xin Wang and Guowen Wang

    Citation: BMC Cancer 2019 19:238

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  27. Content type: Case report

    Perivascular Epithelioid Cell Tumors (PEComa) is an extraordinarily rare mesenchymal neoplasm especially the malignant type originating from the lung. To date, only 8 cases of malignant or malignant potential ...

    Authors: Jikai Zhao, Haohua Teng, Ruiying Zhao, Wenjie Ding, Keke Yu, Lei Zhu, Jie Zhang and Yuchen Han

    Citation: BMC Cancer 2019 19:235

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  28. Content type: Research article

    Cancer progression is influenced by a pro-tumorigenic microenvironment. The aberrant tumor stroma with increased collagen deposition, contractile fibroblasts and dysfunctional vessels has a major impact on the...

    Authors: Hilde Ytre-Hauge Smeland, Ning Lu, Tine V. Karlsen, Gerd Salvesen, Rolf K. Reed and Linda Stuhr

    Citation: BMC Cancer 2019 19:234

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  29. Content type: Research article

    Alternative lengthening of telomeres (ALT) is a telomerase-independent mechanism used by a broad range of neoplasms to maintain telomere length, permitting uncontrolled replication during their progression. AL...

    Authors: Rita T. Lawlor, Nicola Veronese, Antonio Pea, Alessia Nottegar, Lee Smith, Camilla Pilati, Jacopo Demurtas, Matteo Fassan, Liang Cheng and Claudio Luchini

    Citation: BMC Cancer 2019 19:232

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  30. Content type: Study protocol

    Advanced esophageal squamous cell cancer (ESCC) is frequently diagnosed in elderly patients. The impact of 2nd line chemotherapy is poorly defined. Recent data demonstrated effectiveness of checkpoint inhibito...

    Authors: Nadja M. Meindl-Beinker, Johannes Betge, Tobias Gutting, Elke Burgermeister, Sebastian Belle, Tianzuo Zhan, Nadine Schulte, Martin Maenz, Matthias P. Ebert and Nicolai Haertel

    Citation: BMC Cancer 2019 19:231

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  31. Content type: Research article

    Breast cancer is the most common cancer in women worldwide, with a great diversity in outcomes among individual patients. The ability to accurately predict a breast cancer outcome is important to patients, phy...

    Authors: Minh Tung Phung, Sandar Tin Tin and J. Mark Elwood

    Citation: BMC Cancer 2019 19:230

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  32. Content type: Research article

    Prostate cancer (PCa) is the most common diagnosed malignancy and the second leading cause of cancer-related deaths among men in the United States. High-throughput genotyping has enabled discovery of germline ...

    Authors: Tarun Karthik Kumar Mamidi, Jiande Wu and Chindo Hicks

    Citation: BMC Cancer 2019 19:229

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  33. Content type: Research article

    Despite strong evidence of benefit, breast cancer risk assessment and chemoprevention are underutilized by primary care physicians. This study evaluates the impact of an educational program on knowledge and ut...

    Authors: Siddhartha Yadav, Sarah Hartkop, Paola Yumpo Cardenas, Rand Ladkany, Alexandra Halalau, Sandor Shoichet, Michael Maddens and Dana Zakalik

    Citation: BMC Cancer 2019 19:228

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  34. Content type: Research article

    Gastric cancer (GC) is one of the most commonly occuring gastrointestinal tumor types, and early diagnosis and operation have a notable effect on the prognosis of patients. Although certain markers, including ...

    Authors: Jiaxin Liu, Zhao Liu, Xiaozhi Zhang, Tuotuo Gong and Demao Yao

    Citation: BMC Cancer 2019 19:227

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  35. Content type: Research article

    Glucose metabolism has been suggested as a therapeutic target in ovarian clear cell carcinoma (CCC). We attempted to clarify 18F-FDG PET/CT-based metabolic metrics in the recurrent ovarian CCC patients and their ...

    Authors: Shuang Ye, Shuai Liu, Libing Xiang, Xiaohua Wu and Huijuan Yang

    Citation: BMC Cancer 2019 19:226

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  36. Content type: Research article

    This study aimed to determine whether the enhancer of the rudimentary homolog (ERH) gene regulates cell migration and invasion in human bladder urothelial carcinoma (BUC) T24 cells and the underlying mechanism.

    Authors: Kun Pang, Zhiguo Zhang, Lin Hao, Zhenduo Shi, Bo Chen, Guanghui Zang, Yang Dong, Rui Li, Ying Liu, Jie Wang, Jianjun Zhang, Longjun Cai, Xiaoxiao Han and Conghui Han

    Citation: BMC Cancer 2019 19:225

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  37. Content type: Research article

    Our previous works have demonstrated that 8-bromo-7-methoxychrysin suppressed stemness of human hepatocellular carcinoma (HCC) cell line SMMC-7721 induced by condition medium from hepatic stellate cell line LX...

    Authors: Qi Wen, Chang Xu, Jie Zhou, Nuo-Min Liu, Ying-Hong Cui, Mei-Fang Quan, Jian-Guo Cao and Kai-qun Ren

    Citation: BMC Cancer 2019 19:224

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  38. Content type: Research article

    Previous studies have demonstrated that β2-microglobulin (β2M) promotes the growth and survival of a variety of cancer cells and has different regulatory effects on the expression of Bcl-2 and HER2 in HER2 breas...

    Authors: Dandan Chai, Kesheng Li, Huifen Du, Suisheng Yang, Rong Yang, Yang Xu and Xiaowen Lian

    Citation: BMC Cancer 2019 19:223

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  39. Content type: Research article

    Non-small cell lung cancer (NSCLC) as the most frequent type of lung cancer is associated with extensive mortality. Researchers have studied the suitability of several molecules as biomarkers for early detecti...

    Authors: Farbod Esfandi, Mohammad Taheri, Mir Davood Omrani, Mohammad Behgam Shadmehr, Shahram Arsang-Jang, Roshanak Shams and Soudeh Ghafouri-Fard

    Citation: BMC Cancer 2019 19:222

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  40. Content type: Research article

    Locally advanced uterine cervical cancer (LAUCC) with lateral tumor extension may not always be covered adequately by conventional intracavitary brachytherapy (ICBT). Hybrid intracavitary and interstitial brac...

    Authors: Naoya Murakami, Kazuma Kobayashi, Satoshi Shima, Keisuke Tsuchida, Tairo Kashihara, Nikolaos Tselis, Rei Umezawa, Kana Takahashi, Koji Inaba, Yoshinori Ito, Hiroshi Igaki, Yuko Nakayama, Koji Masui, Ken Yoshida, Tomoyasu Kato and Jun Itami

    Citation: BMC Cancer 2019 19:221

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  41. Content type: Research article

    Breast cancer patient-derived xenograft (BC-PDX) models represent a continuous and reproducible source of circulating tumor cells (CTCs) for studying their role in tumor biology and metastasis. We have previou...

    Authors: Arturo B. Ramirez, Raksha Bhat, Debashish Sahay, Carmine De Angelis, Hariprasad Thangavel, Sina Hedayatpour, Lacey E. Dobrolecki, Agostina Nardone, Mario Giuliano, Chandandeep Nagi, Mothaffar Rimawi, C. Kent Osborne, Michael T. Lewis, Jackie L. Stilwell, Eric P. Kaldjian, Rachel Schiff…

    Citation: BMC Cancer 2019 19:220

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  42. Content type: Research article

    Breast cancer is a highly heterogeneous disease resulting in diverse clinical behaviours and therapeutic responses. DNA methylation is a major epigenetic alteration that is commonly perturbed in cancers. The a...

    Authors: Bernardo P. de Almeida, Joana Dias Apolónio, Alexandra Binnie and Pedro Castelo-Branco

    Citation: BMC Cancer 2019 19:219

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  43. Content type: Research article

    Over 1.3 million people live with colorectal cancer in the United States. Physical activity is associated with lower risk of colorectal cancer recurrence and mortality. Interventions are needed to increase phy...

    Authors: Erin L. Van Blarigan, Hilary Chan, Katherine Van Loon, Stacey A. Kenfield, June M. Chan, Emily Mitchell, Li Zhang, Alan Paciorek, Galen Joseph, Angela Laffan, Chloe E. Atreya, Yoshimi Fukuoka, Christine Miaskowski, Jeffrey A. Meyerhardt and Alan P. Venook

    Citation: BMC Cancer 2019 19:218

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  44. Content type: Research article

    0.17–2% of mature cystic teratoma of the ovary (MCTO) undergo malignant transformation, of which 80% are squamous cell carcinoma (SCC) transformation in MCTO. We aim to investigate the clinical characteristics...

    Authors: Congcong Li, Qing Zhang, Siying Zhang, Ruifen Dong, Chenggong Sun, Chunping Qiu, Zhiwei Zhang, Xingsheng Yang and Beihua Kong

    Citation: BMC Cancer 2019 19:217

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  45. Content type: Research article

    This study sought to explore whether lymphovascular invasion can affect the prognosis of patients with stage N0 gastric cancer and to evaluate the survival benefit of adjuvant chemotherapy for such patients.

    Authors: Jun Lu, Yun Dai, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chao-Hui Zheng, Ping Li and Chang-Ming Huang

    Citation: BMC Cancer 2019 19:216

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  46. Content type: Research article

    PAM50 gene profiling assigns each cancer to a single intrinsic subtype. However, individual cancers vary in their adherence to a prototype, and due to bulk tissue sampling, some may exhibit expression patterns...

    Authors: Neeraj Kumar, Dan Zhao, Dulal Bhaumik, Amit Sethi and Peter H. Gann

    Citation: BMC Cancer 2019 19:215

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  47. Content type: Research article

    The gastric cancer incidence rate differs widely across geographical areas. In Italy, in the province of Cremona the incidence is high, compared to the national situation. For this reason a specialized populat...

    Authors: B. M. Donida, G. Tomasello, M. Ghidini, F. Buffoli, M. Grassi, W. Liguigli, G. Maglietta, L. Pergola, M. Ratti, G. Sabadini, L. Toppo, M. Ungari and R. Passalacqua

    Citation: BMC Cancer 2019 19:212

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  48. Content type: Research article

    MicroRNA-148b (miR-148b) has been detected in various types of tumors, and is generally viewed as a tumor suppressor. Our previous study found the decreased expression of miR-148b in human non small cell lung ...

    Authors: Lin Lu, Qiyao Liu, Peipei Wang, Yong Wu, Xia Liu, Chengyin Weng, Xisheng Fang, Baoxiu Li, Xiaofei Cao, Haibo Mao, Lina Wang, Mingmei Guan, Wei Wang and Guolong Liu

    Citation: BMC Cancer 2019 19:209

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