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  1. The identification of a BRCA1 or BRCA2 mutation in familial breast cancer kindreds allows genetic testing of at risk relatives. However, considerable controversy exists regarding the cancer risks in women who tes...

    Authors: D Gareth Evans, Andrew Shenton, Emma Woodward, Fiona Lalloo, Anthony Howell and Eamonn R Maher
    Citation: BMC Cancer 2008 8:155
    Content type: Research article Published on:

  3. Cell lines constitute a powerful model to study cancer, and here we describe three new epithelial ovarian cancer (EOC) cell lines derived from poorly differentiated serous solid tumors (TOV-1946, and TOV-2223G...

    Authors: Véronique Ouellet, Magdalena Zietarska, Lise Portelance, Julie Lafontaine, Jason Madore, Marie-Line Puiffe, Suzanna L Arcand, Zhen Shen, Josée Hébert, Patricia N Tonin, Diane M Provencher and Anne-Marie Mes-Masson
    Citation: BMC Cancer 2008 8:152
    Content type: Research article Published on:

  4. Tumour hypoxia is known to be a poor prognostic indicator, predictive of increased risk of metastatic disease and reduced survival. Genomic instability has been proposed as one of the potential mechanisms for ...

    Authors: Tuula M Kalliomäki, Gordon McCallum, Sarah Jane Lunt, Peter G Wells and Richard P Hill
    Citation: BMC Cancer 2008 8:151
    Content type: Research article Published on:

  6. In the present study we analyze, in patients with breast cancer, the tumor expression of androgen receptors (AR), its relationship with clinicopathological characteristics and with the expression of several ma...

    Authors: Luis O Gonzalez, Maria D Corte, Julio Vazquez, Sara Junquera, Rosario Sanchez, Ana C Alvarez, Juan C Rodriguez, Maria L Lamelas and Francisco J Vizoso
    Citation: BMC Cancer 2008 8:149
    Content type: Research article Published on:

  7. The objective of this study was to evaluate the efficacy and toxicity of infusional 5-fluorouracil (5-FU), folinic acid and oxaliplatin (modified FOLFOX-6) in patients with advanced gastric cancer (AGC), as fi...

    Authors: Bhumsuk Keam, Seock-Ah Im, Sae-Won Han, Hye Seon Ham, Min A Kim, Do-Youn Oh, Se-Hoon Lee, Jee Hyun Kim, Dong-Wan Kim, Tae-You Kim, Dae Seog Heo, Woo Ho Kim and Yung-Jue Bang
    Citation: BMC Cancer 2008 8:148
    Content type: Research article Published on:

  8. The 21-kDa Vaccinia virus VH1-related (VHR) dual-specific protein phosphatase (encoded by the DUSP3 gene) plays a critical role in cell cycle progression and is itself regulated during the cell cycle. We have pre...

    Authors: Rachel Henkens, Philippe Delvenne, Mohammad Arafa, Michel Moutschen, Mustapha Zeddou, Lutz Tautz, Jacques Boniver, Tomas Mustelin and Souad Rahmouni
    Citation: BMC Cancer 2008 8:147
    Content type: Research article Published on:

  9. BRCA1 and BRCA2 are the two most important genes associated with familial breast and ovarian cancer susceptibility. In addition, PALB2 has recently been identified as a breast cancer susceptibility gene in sever...

    Authors: Katri Pylkäs, Hannele Erkko, Jenni Nikkilä, Szilvia Sólyom and Robert Winqvist
    Citation: BMC Cancer 2008 8:146
    Content type: Research article Published on:

  10. The human gene ERH (Enhancer of the Rudimentary gene Homologue) has previously been identified by in silico analysis of four million ESTs as a gene differentially expressed in breast cancer. The biological functi...

    Authors: Menelaos Zafrakas, Inge Losen, Ruth Knüchel and Edgar Dahl
    Citation: BMC Cancer 2008 8:145
    Content type: Research article Published on:

  11. RET/PTC (rearranged in transformation/papillary thyroid carcinomas) gene rearrangements are the most frequent genetic alterations identified in papillary thyroid carcinoma. Although it has been established tha...

    Authors: Young-Rae Kim, Hee Sun Byun, Minho Won, Kyeong Ah Park, Jin Man Kim, Byung Lyul Choi, Hyunji Lee, Jang Hee Hong, Jongsun Park, Jeong Ho Seok, Dong Wook Kim, Minho Shong, Seung-Kiel Park and Gang Min Hur
    Citation: BMC Cancer 2008 8:144
    Content type: Research article Published on:

  12. IGF binding protein-3 (IGFBP-3) regulates the bioavailability of insulin-like growth factors I and II, and has both anti-proliferative and pro-apoptotic properties. Elevated plasma IGFBP-3 has been associated ...

    Authors: Temitope O Keku, Robert S Sandler, James G Simmons, Joseph Galanko, John T Woosley, Michelle Proffitt, Oluwaseun Omofoye, Maya McDoom and Pauline K Lund
    Citation: BMC Cancer 2008 8:143
    Content type: Research article Published on:

  13. Epithelial growth factor receptor (EGFR) and KRAS mutation status have been reported as predictive markers of tumour response to EGFR inhibitors. High resolution melting (HRM) analysis is an attractive screening ...

    Authors: Hongdo Do, Michael Krypuy, Paul L Mitchell, Stephen B Fox and Alexander Dobrovic
    Citation: BMC Cancer 2008 8:142
    Content type: Research article Published on:

  14. With improved childhood cancer cure rate, long term sequelae are becoming an important factor of quality of life. Signs of cardiovascular disease are frequently found in long term survivors of cancer. Cardiac ...

    Authors: Veronika Velensek, Uros Mazic, Ciril Krzisnik, Damjan Demšar, Janez Jazbec and Berta Jereb
    Citation: BMC Cancer 2008 8:141
    Content type: Research article Published on:

  15. The incidence of breast cancer has doubled over the past 20 years in the Czech Republic. Hereditary factors may be a cause of young onset, bilateral breast or ovarian cancer, and familial accumulation of the d...

    Authors: Eva Machackova, Lenka Foretova, Mirka Lukesova, Petra Vasickova, Marie Navratilova, Ilse Coene, Hana Pavlu, Veronika Kosinova, Jitka Kuklova and Kathleen Claes
    Citation: BMC Cancer 2008 8:140
    Content type: Research article Published on:

  16. Previous studies have found differences in the histological subtypes of lung cancers affecting males and females. Our objective was to investigate trends in the incidence of histological subtypes of lung cance...

    Authors: Victoria A Bennett, Elizabeth A Davies, Ruth H Jack, Vivian Mak and Henrik Møller
    Citation: BMC Cancer 2008 8:139
    Content type: Research article Published on:

  17. Inherited genetic factors such as E-cadherin (CDH1) promoter variants are believed to influence the risk towards sporadic diffuse gastric cancer (DGC). Recently, a new regulatory region essential for CDH1 transcr...

    Authors: Soroush Nasri, Helen More, Francesco Graziano, Annamaria Ruzzo, Emily Wilson, Anita Dunbier, Cushla McKinney, Tony Merriman, Parry Guilford, Mauro Magnani and Bostjan Humar
    Citation: BMC Cancer 2008 8:138
    Content type: Research article Published on:

  18. High incidence rates of gastrointestinal tract cancers have been reported in the Caspian region of Iran. This study aimed to: 1) describe the geographical spatial patterns of gastrointestinal tract cancer inci...

    Authors: Mohammadreza Mohebbi, Mahmood Mahmoodi, Rory Wolfe, Keramat Nourijelyani, Kazem Mohammad, Hojjat Zeraati and Akbar Fotouhi
    Citation: BMC Cancer 2008 8:137
    Content type: Research article Published on:

  19. The number of breast cancer patients diagnosed with ductal carcinoma in situ (DCIS) continues to grow. Laboratory and clinical data indicate that DCIS can progress to invasive disease. Carbohydrate-mediated cell-...

    Authors: Soheila Korourian, Eric Siegel, Thomas Kieber-Emmons and Behjatolah Monzavi-Karbassi
    Citation: BMC Cancer 2008 8:136
    Content type: Research article Published on:

  21. Gastrointestinal stromal tumors (GIST) exhibit an unpredictable clinical course and can rapidly progress to lethality. Predictions about the biological behavior of GIST are based on a number of canonical clini...

    Authors: Dolores Di Vizio, Francesca Demichelis, Sara Simonetti, Guido Pettinato, Luigi Terracciano, Luigi Tornillo, Michael R Freeman and Luigi Insabato
    Citation: BMC Cancer 2008 8:134
    Content type: Research article Published on:

  23. Data exist that demonstrate isoflavones' potent antiproliferative effects on prostate cancer cells. We evaluated the efficacy of isoflavone in patients with PSA recurrent prostate cancer after prior therapy. W...

    Authors: John M Pendleton, Winston W Tan, Satoshi Anai, Myron Chang, Wei Hou, Kathleen T Shiverick and Charles J Rosser
    Citation: BMC Cancer 2008 8:132
    Content type: Research article Published on:

  25. Previous studies and biological mechanisms of carcinogenesis suggest that the steroid receptor content of benign breast epithelium may be related to breast cancer risk. The objective in this study was to compa...

    Authors: Christy G Woolcott, Sandip K SenGupta, Wedad M Hanna and Kristan J Aronson
    Citation: BMC Cancer 2008 8:130
    Content type: Research article Published on:

  26. The oncoprotein HER-2 is over-expressed and/or has undergone gene amplification in between 20 to 30% of breast and ovarian cancers. HER-2 amplified breast cancer is associated with a poor prognosis and increas...

    Authors: Aisha Siddiqa, Linda M Long, Liuxia Li, Robert A Marciniak and Irene Kazhdan
    Citation: BMC Cancer 2008 8:129
    Content type: Research article Published on:

  27. The inactivation of tumor suppressor genes (TSGs) by aberrant DNA methylation plays an important role in the development of malignancy. Since this epigenetic change is reversible, it is a potential target for ...

    Authors: Maryse Lemaire, Guy G Chabot, Noël JM Raynal, Louise F Momparler, Annie Hurtubise, Mark L Bernstein and Richard L Momparler
    Citation: BMC Cancer 2008 8:128
    Content type: Research article Published on:

  29. Breast cancer (BC) mortality is declining such that the number of survivors of BC in the community is increasing. BC survivors report a range of sequelae from their cancer and its management beyond the period ...

    Authors: Marijana Lijovic, Susan R Davis, Pam Fradkin, Maria La China, Helen Farrugia, Rory Wolfe and Robin J Bell
    Citation: BMC Cancer 2008 8:126
    Content type: Research article Published on:

  30. TRP channels have been shown to be involved in tumour generation and malignant growth. However, the expression of these channels in breast cancer remains unclear. Here we studied the expression and function of...

    Authors: Arnaud Guilbert, Isabelle Dhennin-Duthille, Yassine EL Hiani, Nathalie Haren, Hafida Khorsi, Henri Sevestre, Ahmed Ahidouch and Halima Ouadid-Ahidouch
    Citation: BMC Cancer 2008 8:125
    Content type: Research article Published on:

  31. Methotrexate (MTX) uptake is mediated by the reduced folate carrier (RFC). Defective drug uptake in association with decreased RFC expression is a common mechanism of MTX resistance in many tumor types. Heavy ...

    Authors: Rui Yang, Wei-Wei Li, Bang H Hoang, Hansoo Kim, Debabrata Banerjee, Albert Kheradpour, John H Healey, Paul A Meyers, Joseph R Bertino and Richard Gorlick
    Citation: BMC Cancer 2008 8:124
    Content type: Research article Published on:

  32. Hypoxia influences tumor growth by inducing angiogenesis and genetic alterations. Hypoxia-inducible factor 1α (HIF-1α), p53, and vascular endothelial growth factor (VEGF) are all important factors in the mecha...

    Authors: Sung Yong Oh, Hyuk-Chan Kwon, Sung-Hyun Kim, Jin Seok Jang, Min Chan Kim, Kyeong Hee Kim, Jin-Yeong Han, Chung Ock Kim, Su-Jin Kim, Jin-sook Jeong and Hyo-Jin Kim
    Citation: BMC Cancer 2008 8:123
    Content type: Research article Published on:

  33. Among the most prominent metabolic alterations in cancer cells are the increase in glucose consumption and the conversion of glucose to lactic acid via the reduction of pyruvate even in the presence of oxygen....

    Authors: Christoph Otto, Ulrike Kaemmerer, Bertram Illert, Bettina Muehling, Nadja Pfetzer, Rainer Wittig, Hans Ullrich Voelker, Arnulf Thiede and Johannes F Coy
    Citation: BMC Cancer 2008 8:122
    Content type: Research article Published on:

  34. Methyl-CpG binding domain protein 1 (MBD1), a suppressor of gene transcription, may be involved in inactivation of tumor suppressor genes during tumorigenesis. Over-expression of MBD1 has been reported in huma...

    Authors: Chen Liu, Yaohui Chen, Xianjun Yu, Chen Jin, Jin Xu, Jiang Long, Quanxing Ni, Deliang Fu, Hong Jin and Chen Bai
    Citation: BMC Cancer 2008 8:121
    Content type: Research article Published on:

  35. Surgical resection of liver metastases arising from colorectal cancer is considered the only curative treatment option. However, many patients subsequently experience disease recurrence. We prospectively inves...

    Authors: Birgit Gruenberger, Werner Scheithauer, Robert Punzengruber, Christoph Zielinski, Dietmar Tamandl and Thomas Gruenberger
    Citation: BMC Cancer 2008 8:120
    Content type: Research article Published on:

  36. To gain a better understanding of the effects of therapeutic agents on the tumor microenvironment in invasive cancers, we developed a co-culture model from an invasive lobular carcinoma. Tumor cells expressing...

    Authors: Marie P Piechocki
    Citation: BMC Cancer 2008 8:119
    Content type: Research article Published on:

  37. The biological effects of CD24 (FL-80) cross-linking on breast cancer cells have not yet been established. We examined the impact of CD24 cross-linking on human breast cancer cell line MCF-7.

    Authors: Jong Bin Kim, Eunyoung Ko, Wonshik Han, Jeong Eon Lee, Kyung-Min Lee, Incheol Shin, Sangmin Kim, Jong Won Lee, Jihyoung Cho, Ji-Yeon Bae, Hyeon-Gun Jee and Dong-Young Noh
    Citation: BMC Cancer 2008 8:118
    Content type: Research article Published on:

  38. The ATM gene has been frequently involved in hereditary breast cancer as a low-penetrance susceptibility gene but evidence regarding the role of ATM as a breast cancer susceptibility gene has been contradictory.

    Authors: Patricio González-Hormazábal, Teresa Bravo, Rafael Blanco, Carlos Y Valenzuela, Fernando Gómez, Enrique Waugh, Octavio Peralta, Waldo Ortuzar, Jose M Reyes and Lilian Jara
    Citation: BMC Cancer 2008 8:117
    Content type: Research article Published on:

  39. SNP309 T/G (rs2279744) causes higher levels of MDM2, the most important negative regulator of the p53 tumor suppressor. SNP72 G/C (rs1042522) gives rise to a p53 protein with a greatly reduced capacity to indu...

    Authors: Joerg Bittenbring, Frédérique Parisot, Alain Wabo, Monika Mueller, Lynn Kerschenmeyer, Markus Kreuz, Lorenz Truemper, Olfert Landt, Alain Menzel, Michael Pfreundschuh and Klaus Roemer
    Citation: BMC Cancer 2008 8:116
    Content type: Research article Published on:

  40. Hepatitis B virus (HBV) infection in diffuse large B-cell lymphoma (DLBCL) patients is a common complication in China. However, the clinical relevance of HBV infection with respect to DLBCL disease stages and ...

    Authors: Feng Wang, Rui-hua Xu, Hui-yan Luo, Dong-shen Zhang, Wen-qi Jiang, Hui-qiang Huang, Xiao-fei Sun, Zhong-jun Xia and Zhong-zhen Guan
    Citation: BMC Cancer 2008 8:115
    Content type: Research article Published on:

  41. Combined chemo- and radiotherapy are established in breast cancer treatment. Chemotherapy is recommended prior to radiotherapy but decisive data on the optimal sequence are rare. This retrospective analysis ai...

    Authors: Marc D Piroth, Michael Pinkawa, Bernd Gagel, Sven Stanzel, Branka Asadpour and Michael J Eble
    Citation: BMC Cancer 2008 8:114
    Content type: Research article Published on:

  42. The polymorphism SNP309 (rs2279744) in the promoter region of the MDM2 gene has been shown to alter protein expression and may play a role in the susceptibility to lung cancer. The MDM2 protein is a key inhibitor...

    Authors: Kirstin Mittelstrass, Wiebke Sauter, Albert Rosenberger, Thomas Illig, Maria Timofeeva, Norman Klopp, Hendrik Dienemann, Eckart Meese, Gerhard Sybrecht, Gabi Woelke, Mathias Cebulla, Maria Degen, Harald Morr, Peter Drings, Andreas Groeschel, Karsten Grosse Kreymborg…
    Citation: BMC Cancer 2008 8:113
    Content type: Research article Published on:

  43. Patients with chronic inflammatory bowel disease (IBD) are at an increased risk of colorectal cancer (CRC) and it is estimated that one in six persons diagnosed with IBD will develop CRC. This fact suggests th...

    Authors: Janina Suchy, Ewa Kłujszo-Grabowska, Józef Kładny, Cezary Cybulski, Dominika Wokołorczyk, Jolanta Szymańska-Pasternak, Grzegorz Kurzawski, Rodney J Scott and Jan Lubiński
    Citation: BMC Cancer 2008 8:112
    Content type: Research article Published on:

  44. Breast cancer is the first cause of cancer death among women and its incidence doubled in the last two decades. Several approaches for the treatment of these cancers have been developed. The axillary lymph nod...

    Authors: Anne Robe, Emilie Pic, Henri-Pierre Lassalle, Lina Bezdetnaya, François Guillemin and Frédéric Marchal
    Citation: BMC Cancer 2008 8:111
    Content type: Research article Published on:

  45. On its physiological cellular context, PTTG1 controls sister chromatid segregation during mitosis. Within its crosstalk to the cellular arrest machinery, relies a checkpoint of integrity for which gained the o...

    Authors: Manuel Hidalgo, Jose Jorge Galan, Carmen Sáez, Eduardo Ferrero, Carolina Castilla, Reposo Ramirez-Lorca, Pablo Pelaez, Agustin Ruiz, Miguel A Japón and Jose Luis Royo
    Citation: BMC Cancer 2008 8:110
    Content type: Research article Published on:

  46. Xenobiotic Metabolizing Enzymes (XMEs) contribute to the detoxification of numerous cancer therapy-induced products. This study investigated the susceptibility and prognostic implications of the CYP2E1, CYP2C1...

    Authors: Achraf Khedhaier, Elham Hassen, Noureddine Bouaouina, Sallouha Gabbouj, Slim Ben Ahmed and Lotfi Chouchane
    Citation: BMC Cancer 2008 8:109
    Content type: Research article Published on:

  47. Nanog, nucleostemin (NS) and musashi1 (Msi1) are proteins that are highly expressed in undifferentiated embryonic stem (ES) cells and have been shown to be essential in maintaining the pluripotency and regulat...

    Authors: Feng Ye, Caiyun Zhou, Qi Cheng, Jiajie Shen and Huaizeng Chen
    Citation: BMC Cancer 2008 8:108
    Content type: Research article Published on:

  48. Breast carcinomas represent a heterogeneous group of tumors diverse in behavior, outcome, and response to therapy. Identification of proteins resembling the tumor biology can improve the diagnosis, prediction,...

    Authors: Jan Vydra, Irena Selicharová, Kateřina Smutná, Miloslav Šanda, Eva Matoušková, Eva Buršíková, Markéta Prchalová, Zuzana Velenská, David Coufal and Jiří Jiráček
    Citation: BMC Cancer 2008 8:107
    Content type: Research article Published on:

  49. Mantle cell lymphoma (MCL) is an incurable B cell lymphoma and accounts for 6% of all non-Hodgkin's lymphomas. On the genetic level, MCL is characterized by the hallmark translocation t(11;14) that is present ...

    Authors: Steffen Blenk, Julia C Engelmann, Stefan Pinkert, Markus Weniger, Jörg Schultz, Andreas Rosenwald, Hans K Müller-Hermelink, Tobias Müller and Thomas Dandekar
    Citation: BMC Cancer 2008 8:106
    Content type: Research article Published on:

  50. Loss of heterozygosity (LOH) at chromosome arm 16q is frequently observed in human breast cancer, suggesting that one or more target tumor suppressor genes (TSGs) are located there. However, detailed mapping o...

    Authors: Anne-Marie Cleton-Jansen, Ronald van Eijk, Marcel Lombaerts, Marjanka K Schmidt, Laura J Van't Veer, Katja Philippo, Rhyenne ME Zimmerman, Johannes L Peterse, Vincent TBHM Smit, Tom van Wezel and Cees J Cornelisse
    Citation: BMC Cancer 2008 8:105
    Content type: Research article Published on:

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