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  1. Methylation levels may be associated with and serve as markers to predict risk of progression of precancerous cervical lesions. We conducted an epigenome-wide association study (EWAS) of CpG methylation and pr...

    Authors: Alexandra Bukowski, Cathrine Hoyo, Nadja A. Vielot, Misa Graff, Michael R. Kosorok, Wendy R. Brewster, Rachel L. Maguire, Susan K. Murphy, Belinda Nedjai, Efthymios Ladoukakis, Kari E. North and Jennifer S. Smith
    Citation: BMC Cancer 2023 23:1072
    Content type: Research Published on:

  2. Although the prognostic value of the Controlling Nutritional Status (CONUT) score in diffuse large B-cell lymphoma (DLBCL) has been reported in several previous studies, its clinical relevance for the presence...

    Authors: Se-Il Go, Bong-Hoi Choi, Mi Jung Park, Sungwoo Park, Myoung Hee Kang, Hoon-Gu Kim, Jung Hun Kang, Eun Jeong Jeong and Gyeong-Won Lee
    Citation: BMC Cancer 2023 23:1071
    Content type: Research Published on:

  3. Colorectal cancer is a common malignant tumour. Invasive growth and distant metastasis are the main characteristics of its malignant biological behaviour, and they are also the primary factors leading to death...

    Authors: Bin Liu, Xin Zheng, Jiajun Li, Peng Yao, Peng Guo, Wei Liu and Gaoping Zhao
    Citation: BMC Cancer 2023 23:1070
    Content type: Research Published on:

  4. Immune checkpoint inhibitors (ICIs) are commonly used to treat lung cancer patients, but their use can lead to immune-related adverse events (irAEs), which pose a challenge for treatment strategies. The impact...

    Authors: Kaijun Che, Chen Hong, Yanqing He, Duanyang Peng, Zhimin Zeng and Anwen Liu
    Citation: BMC Cancer 2023 23:1069
    Content type: Research Published on:

  5. Chemoradiotherapy (CRT) with concurrent cisplatin is the standard of care as a nonsurgical definitive treatment for patients with locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN). Howev...

    Authors: Tomoya Yokota, Sadamoto Zenda, Takeshi Kodaira, Naomi Kiyota, Yasushi Fujimoto, Koichiro Wasano, Ryo Takahashi, Takashi Mizowaki, Akihiro Homma, Keita Sasaki, Ryunosuke Machida, Yuta Sekino and Haruhiko Fukuda
    Citation: BMC Cancer 2023 23:1068
    Content type: Study Protocol Published on:

  6. Tumor-specific growth factor (TSGF) is an immune-related factor that offers good performance in the clinical management of human cancers. However, the role of serum TSGF in esophageal squamous cell carcinoma (...

    Authors: Xiaoqin Xu, Weigang Wang, Baoguo Tian, Xiaofang Zhang, Yanfen Ji and Jiexian Jing
    Citation: BMC Cancer 2023 23:1067
    Content type: Research Published on:

  7. In muscle-invasive bladder cancer (MIBC), neoadjuvant chemotherapy (NAC) combined with radical cystectomy (RC) is critical in reducing disease recurrence, with GC (gemcitabine and cisplatin) being one of the m...

    Authors: Lanpeng Lu, Chaohu Chen, Hui Cheng, Hui Ding, Junqiang Tian, Hanzhang Wang and Zhiping Wang
    Citation: BMC Cancer 2023 23:1066
    Content type: Research Published on:

  8. Fringe is a glycosyltransferase involved in tumor occurrence and metastasis. However, a comprehensive analysis of the Fringe family members lunatic fringe (LFNG), manic fringe (MFNG), radical fringe (RFNG) in ...

    Authors: Xun Gong, Chenglong Zheng, Haiying Jia, Yangruiyu Liu, Rui Yang, Zizhou Chen, Yihang Pan, Xiaowu Li and Yuchen Liu
    Citation: BMC Cancer 2023 23:1065
    Content type: Research Published on:

  9. The recurrence site that influences post-recurrence survival (PRS) in patients with non-small cell lung cancer (NSCLC) undergoing surgery and the preoperative predictors of recurrence remain unclear.

    Authors: Tetsuya Isaka, Hiroyuki Adachi, Kotaro Murakami, Jun Miura, Noritake Kikunishi, Naoko Shigeta, Yujin Kudo, Yoshihiro Miyata, Morihito Okada, Norihiko Ikeda and Hiroyuki Ito
    Citation: BMC Cancer 2023 23:1064
    Content type: Research Published on:

  10. To evaluate survival rates of hepatocellular carcinoma (HCC), the Chiang Mai Cancer Registry provided characteristics data of 6276 HCC patients diagnosed between 1998-2020 based on evolution of imaging diagnos...

    Authors: Nawapon Nakharutai, Imjai Chitapanarux, Patrinee Traisathit, Pimwarat Srikummoon, Suwalee Pojchamarnwiputh, Nakarin Inmutto and Wittanee Na Chiangmai
    Citation: BMC Cancer 2023 23:1063
    Content type: Research Published on:

  11. This study aimed to find out the characteristics in relation to tumor recurrence in diffused-tenosynovial giant cell tumor of temporomandibular joint and to develop and validate the prognostic model for person...

    Authors: Ying Liu, Yingying Huang, Dongwang Zhu, Jiang Li, Tongchao Zhao, Yining He, Ronghui Xia and Laiping Zhong
    Citation: BMC Cancer 2023 23:1062
    Content type: Research Published on:

  12. Endocrine therapy is frequently administered in patients with hormone dependent (HR+) metastatic endometrial cancer. ESR1 mutations have emerged as a key mechanism of aromatase inhibitor (AI) resistance in HR + m...

    Authors: Aurélien Drouyer, Ludivine Beaussire, Pauline Jorda, Marianne Leheurteur, Cécile Guillemet, Anca Berghian, Dragos Georgescu, Frédéric Di Fiore, Anne Perdrix and Florian Clatot
    Citation: BMC Cancer 2023 23:1061
    Content type: Research Published on:

  14. Preoperative (chemo)radiotherapy has been widely used as an effective treatment for locally advanced rectal cancer (LARC), leading to a significant reduction in pelvic recurrence rates. Because early administr...

    Authors: Min Kyu Kang, Soo Yeun Park, Jun Seok Park, Hye Jin Kim, Jong Gwang Kim, Byung Woog Kang, Jin Ho Baek, Seung Hyun Cho, An Na Seo, Duck-Woo Kim, Jin Kim, Se Jin Baek, Ji Hoon Kim, Ji Yeon Kim, Gi Won Ha, Eun Jung Park…
    Citation: BMC Cancer 2023 23:1059
    Content type: Study Protocol Published on:

  15. Venetoclax is clinically active in treating relapsed/refractory multiple myeloma (RRMM). This study evaluated the efficacy and safety of venetoclax or venetoclax with other agents in treating RRMM.

    Authors: Xiaohui Gao, Hui Zeng, Xiaoyan Zhao, Haibing Wu, Minchao Yan, Yuan Li, Gang Zhang and Fei Sun
    Citation: BMC Cancer 2023 23:1058
    Content type: Research Published on:

  16. One of the most frequently reported effects of cancer and its treatments is cancer-related cognitive impairment (CRCI). Viral infections may affect inflammation and immune function and therefore may influence ...

    Authors: Rachel I. Vogel, Ashley E. Stenzel, Heewon Lee, DeVon Hunter-Schlichting, Erin Wesley, Locke D. Uppendahl, Melissa A. Geller and Heather H. Nelson
    Citation: BMC Cancer 2023 23:1057
    Content type: Research Published on:

  17. Ibrutinib, a first-in-class inhibitor of Bruton’s tyrosine kinase, is approved for the treatment of various B-cell malignancies and chronic graft-versus-host disease. Based on encouraging preclinical data, saf...

    Authors: Do-Youn Oh, Maria Alsina Maqueda, David I. Quinn, Peter J. O’Dwyer, Ian Chau, Sun Young Kim, Ignacio Duran, Daniel Castellano, Jordan Berlin, Begona Mellado, Stephen K. Williamson, Keun-Wook Lee, Francisca Marti, Paul Mathew, Muhammad Wasif Saif, Ding Wang…
    Citation: BMC Cancer 2023 23:1056
    Content type: Research Published on:

  18. This study aims to assess the nutritional status of patients during the different phases of the Chimeric Antigen Receptor (CAR)-T cell therapy and to identify prominent risk factors of hypoalbuminemia in patie...

    Authors: Shuyi Ding, Rongrong Chen, Linqin Wang, Cheng Zu, Xiaoyu Zhou, Jianli Zhang, Mingming Zhang, Aiyun Jin, Tingting Wang and Yongxian Hu
    Citation: BMC Cancer 2023 23:1055
    Content type: Research Published on:

  19. Oropharyngeal squamous cell carcinoma (OPSCC) is the only subgroup of head neck cancer that presents with an increased incidence. Gender-specific studies in other cancer entities have revealed differences in t...

    Authors: Charlotte Klasen, Nora Wuerdemann, Pauline Rothbart, Johanna Prinz, Hans Nicholaus Casper Eckel, Malte Suchan, Christopher Kopp, Jannik Johannsen, Maria Ziogas, Arthur Charpentier, Christian Ulrich Huebbers, Shachi Jenny Sharma, Christine Langer, Christoph Arens, Steffen Wagner, Alexander Quaas…
    Citation: BMC Cancer 2023 23:1054
    Content type: Research Published on:

  20. Breast cancer is the most common malignancy globally, and is considered a major cause of cancer-related death. Tremendous effort is exerted to identify an optimal anticancer drug with limited side effects. The...

    Authors: Randa El-Gamal, Sara Elfarrash, Mohammad EL-Nablaway, Asmaa Ahmed Salem, Seyed-Omar Zaraei, Hanan S. Anbar, Ashraf Shoma and Mohammed I. El-Gamal
    Citation: BMC Cancer 2023 23:1053
    Content type: Research Published on:

  21. To detect the HPV genotype and integration sites in patients with high-risk HPV infection at different stages of photodynamic therapy using nanopore technology and to evaluate the treatment effect.

    Authors: Xiulan Li, Xiaoke Wei, Xin Liu, Nan Wang, Fuqiang Xu, Xingyu Liu, Yanmei Li, Yuxiang Zhou, Huadong Tang, Meina Bian, Ying Hou, Lili Zhang, Weiwei Wang and Qing Liu
    Citation: BMC Cancer 2023 23:1052
    Content type: Research Published on:

  22. Little is known about predictive factors for survival outcomes of esophageal carcinoma (EC) patients who developed recurrence after undergoing multimodal therapies. We aimed to investigate long-term outcomes a...

    Authors: Kotaro Sugawara, Daiji Oka, Hiroki Hara, Takako Yoshii, Hiroki Ushijima, Shigehiro Kudo and Takashi Fukuda
    Citation: BMC Cancer 2023 23:1051
    Content type: Research Published on:

  23. Breast cancer is presently the most commonly diagnosed cancer in women, and it stands as the leading cause of cancer-related deaths worldwide. Notably, breast cancer rates have seen a significant increase in s...

    Authors: Hiwot Fentie, Peter Austin Morton Ntenda and Fentanesh Nibret Tiruneh
    Citation: BMC Cancer 2023 23:1050
    Content type: Research Published on:

  24. A robust evidence base is required to assist healthcare commissioners and providers in selecting effective and sustainable approaches to improve cancer diagnosis and treatment. Such evidence can be difficult t...

    Authors: Erica Wirrmann Gadsby, Carson Brown, Claire Crawford, Glen Dale, Edward Duncan, Linda Galbraith, Karen Gold, Carina Hibberd, Agi McFarland, Jennifer McGlashan, Melanie McInnes, Joanne McNaughton, Juliette Murray, Esme Radin, Piotr Teodorowski and Jane Thomson
    Citation: BMC Cancer 2023 23:1049
    Content type: Study Protocol Published on:

  25. Thyroid cancer (THCA) has become increasingly common in recent decades, and women are three to four times more likely to develop it than men. Evidence shows that estrogen has a significant impact on THCA proli...

    Authors: Leiying Zhang, Man Zhou, Xiaoni Gao, Yang Xie, Junqi Xiao, Tao Liu and Xiangtai Zeng
    Citation: BMC Cancer 2023 23:1048
    Content type: Research Published on:

  26. Lung adenocarcinoma (LUAD) is a common type of malignant tumor with poor prognosis and high mortality. In our previous studies, we found that estrogen is an important risk factor for LUAD, and different estrog...

    Authors: Yangwei Wang, Tong Yu, Jiaping Chen, Rong Zhao, Mingxin Diao, Peiyuan Mei, Shiwen He, Wenlin Qiu, Guanchao Ye, Lijuan Jiang, Han Xiao and Yongde Liao
    Citation: BMC Cancer 2023 23:1047
    Content type: Research Published on:

  27. Rhabdomyosarcoma is the most common soft tissue sarcoma in children, but rare in adults. Para-meningeal rhabdomyosarcoma in head and neck (PM-HNRMS) is less applicable for surgery due to the anatomic reason. P...

    Authors: Kenji Tsuchihashi, Mamoru Ito, Shuji Arita, Hitoshi Kusaba, Wataru Kusano, Takashi Matsumura, Takafumi Kitazono, Shohei Ueno, Ryosuke Taguchi, Tomoyasu Yoshihiro, Yasuhiro Doi, Kohei Arimizu, Hirofumi Ohmura, Tatsuhiro Kajitani, Kenta Nio, Michitaka Nakano…
    Citation: BMC Cancer 2023 23:1046
    Content type: Research Published on:

  28. Resistance to immune checkpoint inhibitors (ICI) is a significant issue in metastatic renal cell carcinoma (mRCC), as it is in the majority of cancer types. An important deficiency in immunooncology today is t...

    Authors: Volkan Aslan, Atiye Cenay Karabörk Kılıç, Ahmet Özet, Aytuğ Üner, Nazan Günel, Ozan Yazıcı, Gözde Savaş, Ahmet Bayrak, Emrah Eraslan, Berna Öksüzoğlu, Hüseyin Koray Kılıç and Nuriye Özdemir
    Citation: BMC Cancer 2023 23:1045
    Content type: Research Published on:

  29. Pancreatic cancer is a highly lethal disease with no effective treatments. Lactobacillus casei (L. casei) and Lactobacillus reuteri (L. reuteri) exhibited therapeutic effects on several cancers, but their roles i...

    Authors: Zemin Zhu, Bo Yi, Zikai Tang, Xun Chen, Ming Li, Tao Xu, Zhijian Zhao and Caixi Tang
    Citation: BMC Cancer 2023 23:1044
    Content type: Research Published on:

  30. It remains uncertain whether first-line treatment with upfront brain radiotherapy (RT) in combined with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is superior to EGFR-TKIs alone fo...

    Authors: Yaowen Song, Shuiyu Lin, Jun Chen and Jun Dang
    Citation: BMC Cancer 2023 23:1043
    Content type: Research Published on:

  31. Adropin is encoded by the energy homeostasis-associated (ENHO) gene and widely present in liver, pancreas, heart, kidney, brain, and vascular tissues. Abnormal adropin is associated with metabolic, inflammatory, ...

    Authors: Linghui Jia, Liting Liao, Yongshuai Jiang, Xiangyu Hu, Guotao Lu, Weiming Xiao, Weijuan Gong and Xiaoqin Jia
    Citation: BMC Cancer 2023 23:1042
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2023 23:1094

  33. Radio/chemotherapy and immune systems provide examples of hormesis, as tumours can be stimulated (or reduced) at low radio/chemical or antibody doses but inhibited (or stimulated) by high doses.

    Authors: Sanyi Tang, Shuo Li, Biao Tang, Xia Wang, Yanni Xiao and Robert A. Cheke
    Citation: BMC Cancer 2023 23:1040
    Content type: Research article Published on:

  34. The immune checkpoint HERV-H LTR-associating 2 (HHLA2) is expressed in kidney cancer and various other tumor types. Therapeutics targeting HHLA2 or its inhibitory receptor KIR3DL3 are being developed for solid...

    Authors: Tomonari Shigemura, Nahuel Perrot, Zimo Huang, Rupal S. Bhatt, Aseman Bagheri Sheshdeh, Nourhan El Ahmar, Fatme Ghandour, Sabina Signoretti, David F. McDermott, Gordon J. Freeman and Kathleen M. Mahoney
    Citation: BMC Cancer 2023 23:1039
    Content type: Research Published on:

  35. In the last decades, an increasing incidence of testicular cancer has been observed in several countries worldwide. Although mortality rates have been variable in many countries, little information is availabl...

    Authors: Yuleizy Crispin-Rios, Mariafe Faura-Gonzales, J. Smith Torres-Roman, Carlos Quispe-Vicuña, Uriel S. Franco-Jimenez, Bryan Valcarcel, Andreas Stang and Katherine A. McGlynn
    Citation: BMC Cancer 2023 23:1038
    Content type: Research Published on:

  36. The emergence of image-based systems to improve diagnostic pathology precision, involving the intent to label sets or bags of instances, greatly hinges on Multiple Instance Learning for Whole Slide Images(WSIs...

    Authors: Rukhma Aftab, Yan Qiang, Juanjuan Zhao, Zia Urrehman and Zijuan Zhao
    Citation: BMC Cancer 2023 23:1037
    Content type: Research Published on:

  37. Given high rates of cancer mortality in Native communities, we examined how urban American Indian and Alaska Native elders talk about colorectal cancer (CRC) and CRC screening.

    Authors: Dedra S. Buchwald, Deborah R. Bassett, Emily R. Van Dyke, Raymond M. Harris, Jessica D. Hanson and Shin-Ping Tu
    Citation: BMC Cancer 2023 23:1036
    Content type: Research Published on:

  38. Myelodysplastic Neoplasms (MDS) are clonal stem cell disorders characterized by ineffective hematopoiesis and progression to acute myeloid leukemia, myelodysplasia-related (AML-MR). A major mechanism of pathog...

    Authors: Ashikh A. Seethy, Karthikeyan Pethusamy, Tushar Kushwaha, Gaurav Kumar, Joyeeta Talukdar, Rekha Chaubey, Udayakumar Dharmalingam Sundaram, Manoranjan Mahapatra, Renu Saxena, Ruby Dhar, Krishna K. Inampudi and Subhradip Karmakar
    Citation: BMC Cancer 2023 23:1035
    Content type: Research Published on:

  39. Cervical cancer is one of the most malignancies in women all over the world. Over 90% of cases occurred in low and middle-income countries with limited resources. Even though cervical cancer is preventable, th...

    Authors: Ketemaw Tsegaye, Asebe Hagos, Hailemichael Kindie, Amare Minyihun and Getachew Teshale
    Citation: BMC Cancer 2023 23:1034
    Content type: Research Published on:

  40. To compare the efficacy and safety of TACE combined with Donafenib and Toripalimab versus TACE combined with Sorafenib in the treatment of unresectable hepatocellular carcinoma (HCC), aiming to guide personali...

    Authors: Haohao Lu, Bin Liang, Xiangwen Xia and Chuansheng Zheng
    Citation: BMC Cancer 2023 23:1033
    Content type: Research Published on:

  41. Gastric cancer (GC) remains among the most common and most lethal cancers worldwide. Peritoneum is the most common site for distant dissemination. Standard treatment for GC peritoneal metastases (PM) is a syst...

    Authors: Martynas Luksta, Augustinas Bausys, Klaudija Bickaite, Rokas Rackauskas, Marius Paskonis, Raminta Luksaite-Lukste, Anastasija Ranceva, Rokas Stulpinas, Birute Brasiuniene, Edita Baltruskeviciene, Nadezda Lachej, Rasa Sabaliauskaite, Rimantas Bausys, Skaiste Tulyte and Kestutis Strupas
    Citation: BMC Cancer 2023 23:1032
    Content type: Study Protocol Published on:

  42. One-half of hormone receptor-positive (HR +) breast cancer (BC) patients have low expression of HER2 (HER2-low) and may benefit from trastuzumab deruxtecan (TDXd). This study aimed to identify parameters assoc...

    Authors: Didi Feldman, Liat Anabel Sinberger, Mali Salmon-Divon, Judith Ben-Dror, Shlomit Strulov Shachar and Amir Sonnenblick
    Citation: BMC Cancer 2023 23:1031
    Content type: Research Published on:

  43. Platelet (PLT) count at diagnosis plays an important role in cancer development and progression in solid tumors. However, it remains controversial whether PLT count at diagnosis influences therapeutic outcome ...

    Authors: Yujiao Zhang, Quan Wu, Baoyi Yuan, Yun Huang, Ling Jiang, Fang Liu, Ping Yan, Yongshuai Jiang, Jieyu Ye and Xuejie Jiang
    Citation: BMC Cancer 2023 23:1030
    Content type: Research Published on:

  44. Necroptosis has been reported to be involved in cancer progression and associated with cancer prognosis. However, the prognostic values of necroptosis-related genes (NRGs) in hepatocellular carcinoma (HCC) rem...

    Authors: Qiqi Tao, Zhichao Lang, Yifei Li, Yuxiang Gao, Lifan Lin, Zhengping Yu, Jianjian Zheng and Suhui Yu
    Citation: BMC Cancer 2023 23:1029
    Content type: Research Published on:

  45. The accurate assessment of axillary lymph node metastasis (LNM) in early-stage breast cancer (BC) is of great importance. This study aimed to construct an integrated model based on clinicopathology, ultrasound...

    Authors: Yan Li, Dong Han, Cong Shen and Xiaoyi Duan
    Citation: BMC Cancer 2023 23:1028
    Content type: Research Published on:

  46. Gastric cancer has a complex aetiology including genetic factors. Individual case-control studies of toll like receptor (TLR) 9 (-1237 T/C, -1486 T/C) polymorphisms in the gastric cancer risk were available, a...

    Authors: Yap Zi Qyi, Htar Htar Aung, Saint-Nway Aye, Wong Siew Tung and Cho Naing
    Citation: BMC Cancer 2023 23:1027
    Content type: Research Published on:

  47. Noninvasive and precise methods to estimate treatment response and identify hepatocellular carcinoma (HCC) patients who could benefit from transarterial chemoembolization (TACE) are urgently required. The pres...

    Authors: Ying Zhao, Jian Zhang, Nan Wang, Qihao Xu, Yuhui Liu, Jinghong Liu, Qinhe Zhang, Xinyuan Zhang, Anliang Chen, Lihua Chen, Liuji Sheng, Qingwei Song, Feng Wang, Yan Guo and Ailian Liu
    Citation: BMC Cancer 2023 23:1026
    Content type: Research Published on:

  48. The Wnt/β-catenin signaling pathway plays an important role in embryogenesis and tumorigenesis. In human cancer, abnormal activity of Wnt/β-catenin signaling pathway induces overexpressed of downstream genes, ...

    Authors: Hung-Wen Tsai, Shu-Wen Cheng, Chou-Cheng Chen, I-Wen Chen and Chung-Liang Ho
    Citation: BMC Cancer 2023 23:1025
    Content type: Research Published on:

  49. Human leukocyte antigen-G (HLA-G) has been reported to be aberrantly expressed in colorectal cancer (CRC); however, its prognostic value remains controversial. Hence, our meta-analysis aims to assess the progn...

    Authors: Yingying Zhang, Siying He, Lisha Yu, Chao Shi, Yanyue Zhang and Shiyue Tang
    Citation: BMC Cancer 2023 23:1024
    Content type: Research Published on:

  50. HPV16 and 18 are positively correlated with cervical carcinogenesis. However, HPV prevalence tends to vary according to region, nationality, and environment. The most prevalent high-risk (HR) HPV genotypes are...

    Authors: Nan Lv, Yue Zhao, Yiying Song, Mingyu Ji and Yunying Zhou
    Citation: BMC Cancer 2023 23:1022
    Content type: Research Published on:

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