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  1. The predictive importance of IKZF1del in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) has shown variability across different studies. Thus, the optimal treatment approach for children with IK...

    Authors: Lili Pan, Yiqiao Chen, Kaizhi Weng, Biyun Guo, Shuquan Zhuang, Shuxian Huang, Zhulan Lian, Xiaofang Wang, Nainong Li and Yongzhi Zheng
    Citation: BMC Cancer 2024 24:1070
    Content type: Research Published on:

  2. Thyroid cancer is a common thyroid malignancy. The majority of thyroid lesion needs intraoperative frozen pathology diagnosis, which provides important information for precision operation. As digital whole sli...

    Authors: Tingting He, Shanshan Shi, Yiqing Liu, Lianghui Zhu, Yani Wei, Fenfen Zhang, Huijuan Shi, Yonghong He and Anjia Han
    Citation: BMC Cancer 2024 24:1069
    Content type: Research Published on:

  3. The prognostic value of circulating tumor cells (CTCs) in metastatic breast cancer (MBC) has been extensively studied and verified by the CellSearch® system. Varieties of microfluidic systems have been develop...

    Authors: Liye Wang, Ruoxi Hong, Simei Shi, Shusen Wang, Yong Chen, Chao Han, Mei Li and Feng Ye
    Citation: BMC Cancer 2024 24:1067
    Content type: Research Published on:

  4. Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) are critical components of the extracellular matrix (ECM) in colorectal cancer (CRC). We aimed to evaluate the prognostic value of MMP-...

    Authors: Yusha Wang, Yuhao Wei, Jing Huang, Xinke Li, Diqing You, Li Wang and Xuelei Ma
    Citation: BMC Cancer 2024 24:1065
    Content type: Systematic Review Published on:

  5. Recent studies have increasingly linked Ephrin receptor B2 (EPHB2) to cancer progression. However, comprehensive investigations into the immunological roles and prognostic significance of EPHB2 across various ...

    Authors: Shengshan Xu, Youbin Zheng, Min Ye, Tao Shen, Dongxi Zhang, Zumei Li and Zhuming Lu
    Citation: BMC Cancer 2024 24:1064
    Content type: Research Published on:

  6. Pancreatic cancer is one of the deadliest cancers in the world. In recent years, the incidence and mortality rates of pancreatic cancer have shown an increasing trend year by year. This study investigates the ...

    Authors: Haoran Zhao, Yubao Zhang, Haishi Liu, Yunfeng Wang and Zengfu Song
    Citation: BMC Cancer 2024 24:1063
    Content type: Research Published on:

  7. Intestinal obstruction represents a severe intestinal disease associated with higher mortality rates. However, the determinants of mortality in patients with intestinal obstruction remain inadequately understo...

    Authors: Yuanyuan Wang, Wei Li, Chuan-min Zhou, Zifeng Zhao, Jianwei Ma, Haibo Jiang, Ming Wei, Yingchao Gao, Yongjun Dai, Xing Zhang, Ning Yang, Feng Feng, Jian Zhang, Yiding Ji, Jianjie Liu, Chao Zhang…
    Citation: BMC Cancer 2024 24:1062
    Content type: Research Published on:

  8. The survival rates for children and adolescents with osteosarcoma in low-income countries are poor. Insufficient data regarding the challenges of managing osteosarcoma in resource-limited settings has been pub...

    Authors: Richard Nyeko, Fadhil Geriga, Racheal Angom, Joyce Balagadde Kambugu and Jaques van Heerden
    Citation: BMC Cancer 2024 24:1061
    Content type: Research Published on:

  9. It is challenging to improve the effects of chemotherapy and reduce its adverse impact on the ovaries. Our previous study suggested that the combination of galaxamide could enhance the antitumor effect of cisp...

    Authors: Huan Tao, Zongbin Chen, Bo Yao, Xinyi Ren, Hanlin Shuai, Shihai Xu, Qingbing Zha and Ping Li
    Citation: BMC Cancer 2024 24:1060
    Content type: Research Published on:

  10. Existing evidence suggests telomerase activation is a crucial step in tumorigenesis. The telomerase reverse transcriptase (TERT), encoded by the human TERT gene, is critical for telomerase expression. The TERT rs...

    Authors: Chao Zhou, Yunke Yang, Lu Shen, Lu Wang, Juan Zhang and Xi Wu
    Citation: BMC Cancer 2024 24:1059
    Content type: Research Published on:

  11. Endometrial cancer is the most common gynecological malignancy; however, there is no useful blood diagnostic biomarker. This study aimed to determine the utility of tissue factor pathway inhibitor 2 (TFPI2), a...

    Authors: Mari Uomoto, Yukihide Ota, Yukio Suzuki, Asuna Yumori, Hiroto Narimatsu, Shiro Koizume, Shinya Sato, Yoshiyasu Nakamura, Shohei Myoba, Norihisa Ohtake, Haruya Saji, Etsuko Miyagi and Yohei Miyagi
    Citation: BMC Cancer 2024 24:1058
    Content type: Research Published on:

  12. Early-stage breast cancer (BC) presents a certain risk of recurrence, leading to variable prognoses and complicating individualized management. Yet, preoperative noninvasive tools for accurate prediction of di...

    Authors: Jing Zhang, Hao Sun, Song Gao, Ye Kang and Cong Shang
    Citation: BMC Cancer 2024 24:1057
    Content type: Research Published on:

  14. We aim to explore the differences of the psychological distress of postoperative chemotherapy patients with colorectal cancer between mindfulness intervention combined with homogeneous medical concepts and min...

    Authors: Yaning Feng, Kuanlei Wang, Jianchun Fan, Xueliang Wu, Tian Li and Zhili Yang
    Citation: BMC Cancer 2024 24:1055
    Content type: Research Published on:

  15. In prior research employing iTRAQ (Isobaric Tags for Relative and Absolute Quantitation) technology, we identified a range of proteins in breast cancer tissues exhibiting high levels of acetylation. Despite th...

    Authors: Xiuli Gao, Ting Pan, Yu Gao, Wenbin Zhu, Likun Liu, Wenbo Duan, Cuicui Han, Bo Feng, Wenjing Yan, Qiuhang Song, Yunlong Liu and Liling Yue
    Citation: BMC Cancer 2024 24:1054
    Content type: Research Published on:

  16. The most appropriate time of primary tumor radiotherapy in non-small cell lung cancer(NSCLC) with EGFR-TKIs remains unclear. The aim of this study was to investigate the effect of the time factor of primary tu...

    Authors: Qingsong Li, Na Liang, Weiwei Ouyang, Shengfa Su, Zhu Ma, Yichao Geng, Yinxiang Hu, Huiqin Li and Bing Lu
    Citation: BMC Cancer 2024 24:1053
    Content type: Research Published on:

  17. Epithelial ovarian cancer (EOC) is one of the deadliest gynaecological malignancies worldwide. The aim of this retrospective study was to create a predictive scoring model based on simple immunological and inf...

    Authors: Wenjing Liao, Jia Li, Wangyou Feng, Weina Kong, Yujie Shen, Zijun Chen and Hong Yang
    Citation: BMC Cancer 2024 24:1052
    Content type: Research Published on:

  18. Programmed death-ligand 1 (PD-L1) expression on tumor cells is associated with poor prognosis in several malignancies, while partly contradictory and inconclusive results have been presented for colorectal can...

    Authors: Hampus Nobin, Stina Garvin, Helga Hagman, Björn Nodin, Karin Jirström and Hans Brunnström
    Citation: BMC Cancer 2024 24:1051
    Content type: Research Published on:

  19. Cervical cancer screening is the primary goal in 90-70-90 targets to reduce cervical cancer incidence and mortality by identifying and treating women with precancerous lesions. Although several studies have be...

    Authors: Aklilu Habte Hailegebireal, Habtamu Mellie Bizuayehu and Lire Lemma Tirore
    Citation: BMC Cancer 2024 24:1050
    Content type: Research Published on:

  20. Hepatocellular carcinoma (HCC) is the primary malignant tumor of the liver. c-Myc is one of the most common oncogenes in clinical settings, and amplified levels of c-Myc are frequently found in HCC. Histone de...

    Authors: Yang Liu, Juan Yu, Xiaotong An, Huiling Rao, Zhenpeng Qiu, Jing Ke, Lun Wu, Zhengpeng Zhu, Haojun Deng, Fuyun Wu, Zhaoyang Zhang and Shan Li
    Citation: BMC Cancer 2024 24:1049
    Content type: Research Published on:

  21. Pancreatic cancer is anatomically divided into pancreatic head and body/tail cancers, and some studies have reported differences in prognosis. However, whether this discrepancy is induced from the difference o...

    Authors: Won-Gun Yun, Daeun Kim, Mirang Lee, Youngmin Han, Yoon Soo Chae, Hye-Sol Jung, Young Jae Cho, Wooil Kwon, Joon Seong Park, Daechan Park and Jin-Young Jang
    Citation: BMC Cancer 2024 24:1048
    Content type: Research Published on:

  23. Immune checkpoint inhibitors (ICIs) are rapidly evolving in the management of bladder cancer (BLCA). Nevertheless, effective biomarkers for predicting immunotherapeutic outcomes in BLCA are still insufficient....

    Authors: Zhiwei Fan, Yiting Liu, Xuehai Wang, Yuting Xu, Ruiyao Huang, Weijian Shi, Yi Qu, Jialing Ruan, Chu Zhou, Xinyuan Zhao and Lei Liu
    Citation: BMC Cancer 2024 24:1046
    Content type: Research Published on:

  24. Spontaneous rupture of hepatocellular carcinoma (rHCC) poses a life-threatening complication with a mortality rate of 25–75%. Treatment aims at achieving hemostasis and includes options such as trans-arterial ...

    Authors: Natthaphong Nimitrungtawee, Phichayut Phinyo, Piemkamol Chalidapong and Nakarin Inmutto
    Citation: BMC Cancer 2024 24:1045
    Content type: Research Published on:

  25. In recent years, Iran has witnessed a remarkable increase in the incidence of cancer. This has led to an emerging challenge in the field of oncofertility, which seeks to address the impact of cancer treatments...

    Authors: Marjan Ghaemi, Ideh Rokhzadi, Mohadese Dashtkoohi, Masoud Doosti, Mahroo Rezaeinejad, Mamak Shariat, Sedigheh Hantoushzadeh, Fatemeh Keikha, Nasim Eshraghi and Maliheh Fakehi
    Citation: BMC Cancer 2024 24:1044
    Content type: Research Published on:

  26. The present study aimed to investigate physicians’ perspectives on the diagnosis and treatment decisions for patients with non-small cell lung cancer (NSCLC) harbouring epidermal growth factor receptor (EGFR) ...

    Authors: Yuequan Shi, Yan Xu and Mengzhao Wang
    Citation: BMC Cancer 2024 24:1043
    Content type: Research Published on:

  27. Chitinase-3 like-protein-1 (CHI3L1) is a member of the mammalian chitinase-like proteins and elevated serum CHI3L1 level has been proved to be associated with poor prognosis in hepatocellular carcinoma (HCC). ...

    Authors: Chiyu He, Zhihang Hu, Zuyuan Lin, Hao Chen, Chenghao Cao, Jinyan Chen, Xudong Yang, Huigang Li, Wei Shen, Xuyong Wei, Li Zhuang, Shusen Zheng, Xiao Xu and Di Lu
    Citation: BMC Cancer 2024 24:1042
    Content type: Research Published on:

  28. Ir192 vaginal brachytherapy (IBT) is commonly used for patients with postoperative endometrial cancer (EC). We devised a novel multichannel vaginal applicator that could be equipped with an electronic brachyth...

    Authors: Wenhui Wang, Bei Wang, Lang Yu, Hongnan Zhen, Yue Zhang, Siqi Feng, Zhou Chen, Yuan Zhang, Jie Qiu, Fuquan Zhang and Ke Hu
    Citation: BMC Cancer 2024 24:1041
    Content type: Research Published on:

  29. Glioblastoma (GBM) is a malignant astrocytic tumor and its progression involves the regulation of vascular endothelial growth factor-A (VEGFA). However, the mechanism of VEGFA in regulating GBM progression rem...

    Authors: Yanlong Tian, Xiao Gao, Xuechao Yang, Shangjun Chen and Yufeng Ren
    Citation: BMC Cancer 2024 24:1040
    Content type: Research Published on:

  30. Preoperative hematological parameters are predictors of pathological features and recurrence-free survival (RFS) in various malignancies. However, comprehensive studies of preoperative indicators associated wi...

    Authors: Junbin Zhang, Jinglin Gong, Hong Liu, Wenwen Zhou, Ming Cai and Chengyao Zhang
    Citation: BMC Cancer 2024 24:1039
    Content type: Research Published on:

  31. Prostate cancer (PCa) is a common malignancy in men, with an escalating mortality rate attributed to Recurrence and metastasis. Recent studies have illuminated collagen’s critical regulatory role within the tu...

    Authors: Yunfei Xiao, Cong Lai, Jintao Hu, Yelisudan Mulati, Xiaoting Xu, Jiawen Luo, Degeng Kong, Cheng Liu and Kewei Xu
    Citation: BMC Cancer 2024 24:1038
    Content type: Research Published on:

  32. CD19-targeted chimeric antigen receptors (CAR) T cells are one of the most remarkable cellular therapies for managing B cell malignancies. However, long-term disease-free survival is still a challenge to overc...

    Authors: Erik Montagna, Najla Santos Pacheco de Campos, Victoria Alves Porto, Giselle Correia Próspero da Silva and Eloah Rabello Suarez
    Citation: BMC Cancer 2024 24:1037
    Content type: Research Published on:

  33. The combination of targeted therapy and immunotherapy has improved the clinical outcomes of unresectable hepatocellular Carcinoma (HCC). However, the overall prognosis remains suboptimal. This study aims to ev...

    Authors: Xishu Wang, Ximin Sun, Yongrong Lei, Lingyan Fang, Yuedi Wang, Kai Feng and Feng Xia
    Citation: BMC Cancer 2024 24:1036
    Content type: Research Published on:

  35. Melanoma is a highly aggressive form of skin cancer. The existence of cancer stem cells (CSCs) and tumor immune evasion are two major causes of melanoma progression, but no effective treatment has been found a...

    Authors: Hua Yu, Guiqing Ding, Qianyi Gong, Jinyun Ma, Yan Zhao, Yuanhua Wang, Xi Qiao and Xiaodong Cheng
    Citation: BMC Cancer 2024 24:1034
    Content type: Research Published on:

  36. Transfer RNA-derived fragments (tRFs) are short non-coding RNA (ncRNA) sequences, ranging from 14 to 30 nucleotides, produced through the precise cleavage of precursor and mature tRNAs. While tRFs have been im...

    Authors: Li-Lin Luo, Yue Cao, Juan-Juan Zhang, Yu-Xin Xie, Linhui Li, Hui Yang, Zheng-Bo Long, Li Wang and Wan-Pu Wang
    Citation: BMC Cancer 2024 24:1033
    Content type: Research Published on:

  37. Alzheimer’s disease (AD) manifests with a higher rate of occurrence in women. Previous epidemiological studies have suggested a potential association between AD and gynecological cancers, but the causal relati...

    Authors: Di Cao, Shaobo Zhang, Yini Zhang, Ming Shao, Qiguang Yang and Ping Wang
    Citation: BMC Cancer 2024 24:1032
    Content type: Research Published on:

  38. Does incorporating Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors into endocrine therapy (ET) effectively enhance survival outcomes, notably overall survival (OS), among individuals with hormone receptor-posi...

    Authors: Cailu Luo, Kunlin Yu, Xiaodan Luo, Tao Lian, Xuejuan Liu, Wang Xu and Zhongkui Jin
    Citation: BMC Cancer 2024 24:1031
    Content type: Systematic Review Published on:

  39. Brain metastasis (BrM) is prevalent among patients with NSCLC, and surgical resection of BrM constitutes a promising treatment strategy for local management and histopathological diagnosis, although it is offe...

    Authors: Kazutaka Hosoya, Hiroaki Ozasa, Masahiro Tanji, Hiroshi Yoshida, Hitomi Ajimizu, Takahiro Tsuji, Hironori Yoshida, Yukinori Terada, Noritaka Sano, Yohei Mineharu, Susumu Miyamoto, Toyohiro Hirai and Yoshiki Arakawa
    Citation: BMC Cancer 2024 24:1030
    Content type: Research Published on:

  40. To compare the difference of postoperative anastomotic leakage (AL) rate between neoadjuvant chemoradiotherapy (NCRT) with pembrolizumab and NCRT group, and investigate the risk factors of developing AL for lo...

    Authors: Wei-Xiang Qi, Shuyan Li, Huan Li, Jiayi Chen and Shengguang Zhao
    Citation: BMC Cancer 2024 24:1029
    Content type: Research Published on:

  41. The combination of immunotherapy and antiangiogenic therapy has shown potential in the treatment of numerous malignant tumors, but limited evidence was available for soft tissue sarcomas (STS). Therefore, the ...

    Authors: Shaoli Li, Qunan Sun, Rui Bai, Youping Wang, Hui Wang, Haifeng Chen and Ying Dong
    Citation: BMC Cancer 2024 24:1028
    Content type: Research Published on:

  42. Local recurrence is common after curative resections of rectal cancer. Surgical resection is considered a primary curative treatment option for patients with locally recurrent rectal cancer (LRRC). LRRC often ...

    Authors: Chikako Kusunoki, Mamoru Uemura, Mao Osaki, Nobuo Takiguchi, Masatoshi Kitakaze, Masakatsu Paku, Yuki Sekido, Mitsunobu Takeda, Tsuyoshi Hata, Atsushi Hamabe, Takayuki Ogino, Norikatsu Miyoshi, Mitsuyoshi Tei, Yoshinori Kagawa, Takeshi Kato, Hidetoshi Eguchi…
    Citation: BMC Cancer 2024 24:1027
    Content type: Research Published on:

  43. Navigating the complexity of chronic myeloid leukemia (CML) diagnosis and management poses significant challenges, including the need for accurate prediction of disease progression and response to treatment. A...

    Authors: Malihe Ram, Mohammad Reza Afrash, Khadijeh Moulaei, Mohammad Parvin, Erfan Esmaeeli, Zahra Karbasi, Soroush Heydari and Azam Sabahi
    Citation: BMC Cancer 2024 24:1026
    Content type: Research Published on:

  44. Most studies on tumour progression from precursor lesion toward gallbladder adenocarcinoma investigate lesions sampled from distinct patients, providing an overarching view of pathogenic cascades. Whether this...

    Authors: Sophie Pirenne, Fátima Manzano-Núñez, Axelle Loriot, Sabine Cordi, Lieven Desmet, Selda Aydin, Catherine Hubert, Sébastien Toffoli, Nisha Limaye, Christine Sempoux, Mina Komuta, Laurent Gatto and Frédéric P. Lemaigre
    Citation: BMC Cancer 2024 24:1025
    Content type: Research Published on:

  45. In the past few decades, researchers have made promising progress, including the development of immune checkpoint inhibitors (ICIs) in the therapy of bladder cancer (BLCA). Existing studies mainly focus on sin...

    Authors: Dongshan Chen, Haoyuan Cao, Xiang Zheng, Haojun Wang, Zengchi Han and Wei Wang
    Citation: BMC Cancer 2024 24:1024
    Content type: Research Published on:

  46. The selection of appropriate second-line therapy for liver cancer after first-line treatment failure poses a significant clinical challenge due to the lack of direct comparative studies and standard treatment ...

    Authors: Fenping Lu, Kai Zhao, Miaoqing Ye, Guangyan Xing, Bowen Liu, Xiaobin Li, Yun Ran, Fenfang Wu, Wei Chen and Shiping Hu
    Citation: BMC Cancer 2024 24:1023
    Content type: Systematic Review Published on:

  47. Seeking a noninvasive predictor for BRAF V600E mutation status of pleomorphic xanthoastrocytomas (PXAs) is essential for their prognoses and therapeutic use of BRAF inhibitors. We aimed to noninvasively diagnose

    Authors: Jing Yan, Cuiping Guo, Hongwei Zheng, Yinhua Li, Mengjiao Duan, Chaoli Zhang, Li Cui, Xiaofei Lv, Gui Fu and Jingliang Cheng
    Citation: BMC Cancer 2024 24:1022
    Content type: Research Published on:

  48. Trophinin Associated Protein (TROAP) has been implicated in some tumors, yet its role in renal cell carcinoma (RCC) remains underexplored. This study aims to elucidate the prognostic and therapeutic implicatio...

    Authors: Qinglin Tan, Peiliang Kong, Guobiao Chen, Yanmin Cai, Kejun Liu, Chen Chen, Huiting Mo, Yuancheng Huang, Jianming Lu and Yifen Wu
    Citation: BMC Cancer 2024 24:1021
    Content type: Research Published on:

  50. Triple negative breast cancer (TNBC) is an aggressive subtype with poor prognosis. We aimed to determine whether circulating tumor DNA (ctDNA) and circulating tumor cell (CTC) could predict response and long-t...

    Authors: Jennifer H. Chen, Sridevi Addanki, Dhruvajyoti Roy, Roland Bassett, Ekaterina Kalashnikova, Erik Spickard, Henry M. Kuerer, Salyna Meas, Vanessa N. Sarli, Anil Korkut, Jason B. White, Gaiane M. Rauch, Debu Tripathy, Banu K. Arun, Carlos H. Barcenas, Clinton Yam…
    Citation: BMC Cancer 2024 24:1016
    Content type: Research Published on:

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