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  1. We designed this study based on both a physician practice survey and real-world patient data to: (1) evaluate clinical management practices in extensive-stage small cell lung cancer (ES-SCLC) among medical cen...

    Authors: Bertrand Mennecier, Jonathan Khalifa, Renaud Descourt, Laurent Greillier, Charles Naltet and Lionel Falchero
    Citation: BMC Cancer 2024 24:421
    Content type: Research Published on:

  2. Clear cell carcinoma of the kidney is a common urological malignancy characterized by poor patient prognosis and treatment outcomes. Modulation of vasculogenic mimicry in tumor cells alters the tumor microenvi...

    Authors: Yuming Gu, Qinqin Huang, Yun Wang, Haixia Wang, Zhenhua Xiang, Yu Xu, Xin Wang, Weiguo Liu and Aiju Wang
    Citation: BMC Cancer 2024 24:420
    Content type: Research Published on:

  3. This study aimed to develop and validate a machine learning (ML)-based fusion model to preoperatively predict Ki-67 expression levels in patients with head and neck squamous cell carcinoma (HNSCC) using multip...

    Authors: Weiyue Chen, Guihan Lin, Yongjun Chen, Feng Cheng, Xia Li, Jiayi Ding, Yi Zhong, Chunli Kong, Minjiang Chen, Shuiwei Xia, Chenying Lu and Jiansong Ji
    Citation: BMC Cancer 2024 24:418
    Content type: Research Published on:

  4. Lung cancer is one of the most common type of cancer and, despite significant advances in screening and diagnosis approaches, a large proportion of patients at diagnosis still present advanced stages of the di...

    Authors: Alya Boutabba, Fadoua Missaoui, Akram Dlala, Hela Kamoun, Khalil Ben Salem, Amira Gabsi, Hadhemi Rejeb, Anne Letessier, Benoit Miotto and Raja Marrakchi
    Citation: BMC Cancer 2024 24:417
    Content type: Research Published on:

  5. Through research on the gut microbiota (GM), increasing evidence has indicated that the GM is associated with esophageal cancer (ESCA). However, the specific cause-and-effect relationship remains unclear. In t...

    Authors: Jia Li, Xuedi Gao, Xiaoming Sun, Hao Li, Jiaheng Wei, Lin Lv and Liangming Zhu
    Citation: BMC Cancer 2024 24:416
    Content type: Research Published on:

  6. Genome stability is maintained by the DNA damage repair (DDR) system composed of multiple DNA repair pathways of hundreds of genes. Germline pathogenic variation (PV) in DDR genes damages function of the affec...

    Authors: Bojin Zhao, Jiaheng Li, Siddharth Sinha, Zixin Qin, Si Hoi Kou, Fengxia Xiao, Huijun Lei, Tianhui Chen, Wenming Cao, Xiaofan Ding and San Ming Wang
    Citation: BMC Cancer 2024 24:415
    Content type: Research Published on:

  7. Pancreatic ductal adenocarcinoma (PDAC) presents with a high mortality rate. Two important features of PDAC contribute to this poor outcome. The first is metastasis which occurs in ~ 80% of PDAC patients. The ...

    Authors: Victoria Spadafora, Benjamin R. Pryce, Alexander Oles, Erin E. Talbert, Martin Romeo, Silvia Vaena, Stefano Berto, Michael C. Ostrowski, David J. Wang and Denis C. Guttridge
    Citation: BMC Cancer 2024 24:414
    Content type: Research Published on:

  8. Authors: Zaher Alwafai, Maximilian Heinz Beck, Sepideh Fazeli, Kathleen Gürtler, Christine Kunz, Juliane Singhartinger, Dominika Trojnarska, Dario Zocholl, David Johannes Krankenberg, Jens-Uwe Blohmer, Jalid Sehouli and Klaus Pietzner
    Citation: BMC Cancer 2024 24:413
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2024 24:380

  9. Tumor genomic profiling (TGP) identifies targets for precision cancer treatments, but also secondary hereditary risks. Oncologists are poorly trained to communicate the results of TGP, especially among patient...

    Authors: Michael J. Hall, Paul A. D’Avanzo, Yana Chertock, Patrick J. A. Kelly, Jesse Brajuha, Katie Singley, Caseem C. Luck and Sarah B. Bass
    Citation: BMC Cancer 2024 24:412
    Content type: Research Published on:

  10. Deleterious BRCA1/2 (BRCA) mutation raises the risk for BRCA mutation-related malignancies, including breast, ovarian, prostate, and pancreatic cancer. Germline variation of BRCA exhibits substantial ethnical div...

    Authors: Zhiyuan Wu, Qingyun Zhang, Yiting Jin, Xinju Zhang, Yanli Chen, Can Yang, Xuemei Tang, Haowen Jiang, Xiaoyi Wang, Xinli Zhou, Feng Yu, Bing Wang and Ming Guan
    Citation: BMC Cancer 2024 24:411
    Content type: Research Published on:

  11. High expression of the glycosyltransferase UGT2B17 represents an independent adverse prognostic marker in chronic lymphocytic leukemia (CLL). It also constitutes a predictive marker for therapeutic response an...

    Authors: Michèle Rouleau, Lyne Villeneuve, Eric P. Allain, Jules McCabe-Leroux, Sophie Tremblay, Flora Nguyen Van Long, Ashwini Uchil, Charles Joly-Beauparlant, Arnaud Droit and Chantal Guillemette
    Citation: BMC Cancer 2024 24:410
    Content type: Research Published on:

  12. Accurate evaluation of axillary lymph node metastasis (LNM) in breast cancer is very important. A large number of hyperplastic and dilated lymphangiogenesis cases can usually be found in the pericancerous tiss...

    Authors: Bo Li, Shaochun Dai, Qiucheng Wang, Hui Jing, Hua Shao, Lei Zhang, Ling Qin, Cong Qiao, Zhuozhong Wang and Wen Cheng
    Citation: BMC Cancer 2024 24:409
    Content type: Research Published on:

  13. Accumulating evidence indicates that aberrant non-SMC condensin II complex subunit D3 (NCAPD3) is associated with carcinogenesis of various cancers. Nevertheless, the biological role of NCAPD3 in the pathogene...

    Authors: Fan Yang, Yunfeng Zheng, Qiong Luo, Suyun Zhang, Sheng Yang and Xiangqi Chen
    Citation: BMC Cancer 2024 24:408
    Content type: Research Published on:

  14. Primary central nervous system lymphoma (PCNSL) are rare mature B-cell lymphoproliferative diseases characterized by a high incidence of MYD88 L265P and CD79B Y196 hotspot mutations. Diagnosis of PCNSL can be ...

    Authors: Yujie Zhong, Geok Wee Tan, Johanna Bult, Nick Veltmaat, Wouter Plattel, Joost Kluiver, Roelien Enting, Arjan Diepstra, Anke van den Berg and Marcel Nijland
    Citation: BMC Cancer 2024 24:407
    Content type: Research Published on:

  15. Autologous stem-cell transplantation (ASCT) remains a beneficial approach for patients with newly diagnosed multiple myeloma (NDMM) in the age of novel therapeutic agents. Nevertheless, limited real-world data...

    Authors: Yi Tao, Shiwei Jin, Dan Yang, Mengmeng Pan, Wanyan Ouyang, Yuanfang Liu, Yan Wang, Weiping Zhang and Jianqing Mi
    Citation: BMC Cancer 2024 24:406
    Content type: Research Published on:

  17. Accurate microsatellite instability (MSI) testing is essential for identifying gastric cancer (GC) patients eligible for immunotherapy. We aimed to develop and validate a CT-based radiomics signature to predic...

    Authors: Peng-chao Zhan, Shuo Yang, Xing Liu, Yu-yuan Zhang, Rui Wang, Jia-xing Wang, Qing-ya Qiu, Yu Gao, Dong-bo Lv, Li-ming Li, Cheng-long Luo, Zhi-wei Hu, Zhen Li, Pei-jie Lyu, Pan Liang and Jian-bo Gao
    Citation: BMC Cancer 2024 24:404
    Content type: Research Published on:

  18. During the last decade, twelve studies have been published investigating physical exercise interventions (PEIs) in patients with head and neck cancer (HNC) during radiotherapy (RT), chemoradiation (CRT) or bio...

    Authors: Yvette Kriellaars, Jorine Ariane Vermaire, Maaike Beugeling, Robert Poorter, Janneke Drijvers and Caroline Margina Speksnijder
    Citation: BMC Cancer 2024 24:403
    Content type: Study Protocol Published on:

  19. Among the most common forms of cancer worldwide, breast cancer posed a serious threat to women. Recent research revealed a lack of oxygen, known as hypoxia, was crucial in forming breast cancer. This research ...

    Authors: Chaoran Qiu, Wenjun Wang, Shengshan Xu, Yong Li, Jingtao Zhu, Yiwen Zhang, Chuqian Lei, Weiwen Li, Hongsheng Li and Xiaoping Li
    Citation: BMC Cancer 2024 24:402
    Content type: Research Published on:

  21. This study evaluated the clinical relevance of a set of five serum-derived circulating microRNAs (miRNAs) in colorectal cancer (CRC). Additionally, we investigated the role of miR-20a-5p released by exosomes d...

    Authors: Mahsa Ghofrani-Shahpar, Katayoon Pakravan, Ehsan Razmara, Faezeh Amooie, Mojdeh Mahmoudian, Masoumeh Heshmati and Sadegh Babashah
    Citation: BMC Cancer 2024 24:400
    Content type: Research Published on:

  24. High-risk stage III colon cancer has a considerably poorer prognosis than stage II and low-risk stage III colon cancers. Nevertheless, most guidelines recommend similar adjuvant treatment approaches for all th...

    Authors: Kyung-Ha Lee, In Jun Yang, Gi Won Ha, Jaeim Lee, Youn Young Park, Suk Hwan Lee, Jong Min Lee, Jung Hoon Bae, Eun Jung Park, Hyungjin Kim, Keun Young Kim, Sanghyung An, Ik Yong Kim and Ji Yeon Kim
    Citation: BMC Cancer 2024 24:397
    Content type: Study Protocol Published on:

  25. Emerging data suggested a favorable outcome in advanced non-small cell lung cancer (NSCLC) with chronic obstructive pulmonary disease (COPD) patients treated by immunotherapy. The objective of this study was t...

    Authors: Ao Zeng, Yanze Yin, Zhilong Xu, Abudumijiti Abuduwayiti, Fujun Yang, Mohammed Saud Shaik, Chao Wang, Keyi Chen, Chao Wang, Xinyun Fang and Jie Dai
    Citation: BMC Cancer 2024 24:396
    Content type: Research Published on:

  26. Although immune cell therapy has long been used for treating solid cancer, its efficacy remains limited. Interferon (IFN)-producing killer dendritic cells (IKDCs) exhibit cytotoxicity and present antigens to r...

    Authors: Chih-Hao Fang, Wen-Fang Cheng, Ya-Fang Cheng, Keng-Li Lan and Jan-Mou Lee
    Citation: BMC Cancer 2024 24:395
    Content type: Research Published on:

  27. Bone tumors account for approximately 6% of all cancers in children. Malignant bone tumors, commonly occurring in children and adolescents, are associated with high mortality and morbidity. The overall surviva...

    Authors: Temesgen Lingerih, Sewagegn Yeshiwas, Abdulkadir Mohamedsaid and Gashaw Arega
    Citation: BMC Cancer 2024 24:394
    Content type: Research Published on:

  28. Immune checkpoint inhibitors (ICI) combined with chemotherapy are efficacious for treating advanced non-small cell lung cancer (NSCLC); however, the effectiveness of this approach in the malignant pleural effu...

    Authors: Qi Wei, Taibing Deng, Junhua Wu, Hao Zeng, Chang Qi, Sihan Tan, Yuanyuan Zhang, Qin Huang, Xin Pu, Weiguo Xu, Weimin Li, Panwen Tian and Yalun Li
    Citation: BMC Cancer 2024 24:393
    Content type: Research Published on:

  30. Breast cancer and genital cancer are known as cancers that affect people’s relationships with their partners. Women with such cancers are emotionally vulnerable and need more support from their partners. The p...

    Authors: Hamideh Zahedi, Zohreh Alizadeh-Dibazari, Mojgan Mirghafourvand, Mohammad Hasan Sahebihagh and Mina Hosseinzadeh
    Citation: BMC Cancer 2024 24:391
    Content type: Research Published on:

  32. The objective of this study was to describe real-world adjuvant therapy (AT) use by disease substage and assess determinants of treatment choice among patients with stage III melanoma.

    Authors: Eric D. Whitman, Todor I. Totev, Shan Jiang, Wilson L. da Costa Jr., Dmitri Grebennik, Hongjue Wang, Andra-Ecaterina Boca and Rajeev Ayyagari
    Citation: BMC Cancer 2024 24:389
    Content type: Research Published on:

  33. Breast cancer (BC) is one of the major causes of death worldwide. It is the most common cause of death before the age of 70 years. The incidence and mortality of BC are rapidly increasing, posing great challen...

    Authors: Esmatullah Esmat, Ahmed Maseh Haidary, Ramin Saadaat, Syeda Naghma Rizvi, Syeda Aleena, Mujtaba Haidari, Sayed Murtaza Sadat Hofiani, Nasrin Hussaini, Ahmadullah Hakimi, Abdullatif Khairy and Jamshid Abdul-Ghafar
    Citation: BMC Cancer 2024 24:388
    Content type: Research Published on:

  34. The safety and efficacy of transarterial chemoembolization plus molecular targeted therapy (MTT) combined with immune checkpoint inhibitors (ICIs) in primary liver cancer have been demonstrated. However, the e...

    Authors: Changlong Hou, Baizhu Xiong, Lei Zhou, Yipeng Fei, Changgao Shi, Xianhai Zhu, Tao Xie and Yulin Wu
    Citation: BMC Cancer 2024 24:387
    Content type: Research Published on:

  36. Gliomas are the most common primary intracranial tumor worldwide. The maintenance of telomeres serves as an important biomarker of some subtypes of glioma. In order to investigate the biological role of RTEL1 ...

    Authors: Guanjie Wang, Xiaojuan Ren, Jianying Li, Rongrong Cui, Xumin Zhao, Fang Sui, Juan Liu, Pu Chen, Qi Yang, Meiju Ji, Peng Hou, Ke Gao and Yiping Qu
    Citation: BMC Cancer 2024 24:385
    Content type: Research Published on:

  37. Lung cancer is the leading cause of cancer mortality among Chinese females despite the low smoking prevalence among this population. This study assessed the roles of reproductive factors in lung cancer develop...

    Authors: Marwa M. A. Elbasheer, Bastian Bohrmann, Yiping Chen, Jun Lv, Dianjianyi Sun, Xia Wu, Xiaoming Yang, Daniel Avery, Liming Li, Zhengming Chen, Christiana Kartsonaki, Ka Hung Chan and Ling Yang
    Citation: BMC Cancer 2024 24:384
    Content type: Research Published on:

  38. Macroscopic vascular invasion (MVI) significantly impacts survival in patients with hepatocellular carcinoma (HCC), warranting systemic therapy over locoregional therapy. Despite novel approaches, HCC with MVI...

    Authors: Takashi Kaneko, Hirokazu Makishima, Masaru Wakatsuki, Yuichi Hiroshima, Toshiaki Matsui, Shigeo Yasuda, Naomi Nagatake Okada, Kenji Nemoto, Hiroshi Tsuji, Shigeru Yamada and Masaru Miyazaki
    Citation: BMC Cancer 2024 24:383
    Content type: Research Published on:

  40. Inaccurate colposcopy diagnosis may lead to inappropriate management and increase the incidence of cervical cancer. This study aimed to evaluate the diagnostic accuracy of colposcopy in the detection of histol...

    Authors: Xiaoxiao Li, Yunzhi Zhao, Fenfen Xiang, Xinpei Zhang, Zixi Chen, Mengzhe Zhang, Xiangdong Kang and Rong Wu
    Citation: BMC Cancer 2024 24:381
    Content type: Research Published on:

  41. Multiple studies have indicated that patients with high body mass index (BMI) may have favourable survival outcomes following treatment with an immune checkpoint inhibitor (ICI). However, this evidence is limi...

    Authors: Lee X. Li, Mark A. Socinski, Ganessan Kichenadasse, Christos S. Karapetis, Adel Shahnam, Ross A. McKinnon, Andrew Rowland, Ashley M. Hopkins and Michael J. Sorich
    Citation: BMC Cancer 2024 24:379
    Content type: Research Published on:

  43. The primary aim of this study is to critically evaluate and comment on the research presented in the article titled “A Novel Super-Enhancer-Related Gene Signature Predicts Prognosis and Immune Microenvironment...

    Authors: Matin Chehelgerdi, Milad Khorramian-Ghahfarokhi, Fereshteh Behdarvand Dehkordi and Mohammad Chehelgerdi
    Citation: BMC Cancer 2024 24:377
    Content type: Matters Arising Published on:

  45. Cervical cancer is a major public health issue in Uganda, with high incidence due to limited screening especially in rural areas. In 2019, HPV DNA testing using GeneXpert was rolled out to improve screening ac...

    Authors: Harriet Nakigozi, Paul Mukama Ategyeka, Susan Nabadda and Rawlance Ndejjo
    Citation: BMC Cancer 2024 24:375
    Content type: Research Published on:

  46. Chemo-radiotherapy with curative intent for anal cancer has high complete remission rates, but acute treatment-related gastrointestinal (GI) toxicity is significant. Toxicity occurs due to irradiation of surro...

    Authors: Katrine Smedegaard Storm, Lina M Åström, Patrik Sibolt, Claus P Behrens, Gitte F Persson and Eva Serup-Hansen
    Citation: BMC Cancer 2024 24:374
    Content type: Study Protocol Published on:

  47. Participants considering early-phase cancer clinical trials (CTs) need to understand the unique risks and benefits prior to providing informed consent. This qualitative study explored the factors that influenc...

    Authors: Jonathan Avery, Jennifer A.H. Bell, Khotira Baryolay, Gary Rodin, Rinat Nissim and Lynda G. Balneaves
    Citation: BMC Cancer 2024 24:373
    Content type: Research Published on:

  48. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) recommended for the patients with subsolid nodule in early lung cancer stage is not routinely. The clinical value and impact in patients ...

    Authors: Mei Xie, Jie Gao, Xidong Ma, Jialin Song, Chongchong Wu, Yangyu Zhou, Tianjiao Jiang, Yiran Liang, Chen Yang, Xinyu Bao, Xin Zhang, Jie Yao, Ying Jing, Jianlin Wu, Jianxin Wang and Xinying Xue
    Citation: BMC Cancer 2024 24:372
    Content type: Research Published on:

  49. The need for intelligent and effective treatment of diseases and the increase in drug design costs have raised drug repurposing as one of the effective strategies in biomedicine. There are various computationa...

    Authors: Roohallah Mahdi-Esferizi, Zahra Shiasi, Razieh Heidari, Ali Najafi, Issa Mahmoudi, Fatemeh Elahian and Shahram Tahmasebian
    Citation: BMC Cancer 2024 24:371
    Content type: Research Published on:

  50. Relapsed or refractory follicular lymphoma (rrFL) is an incurable disease associated with shorter remissions and survival after each line of standard therapy. Many promising novel, chemotherapy-free therapies ...

    Authors: Graham McIlroy, Siân Lax, Charlotte Gaskell, Aimee Jackson, Malcolm Rhodes, Tania Seale, Sonia Fox, Lousie Hopkins, Jessica Okosun, Sally F. Barrington, Ingo Ringshausen, Alan G. Ramsay, Maria Calaminici, Kim Linton and Mark Bishton
    Citation: BMC Cancer 2024 24:370
    Content type: Study Protocol Published on:

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