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  1. Cholangiocarcinoma (CCA) is an aggressive solid tumour with a 5-year survival rate ranging from 7% to 20%. It is, therefore, urgent to identify novel biomarkers and therapeutic targets to improve the outcomes ...

    Authors: Zuyi Ma, Tiange Xie, Jia Sun, Jianchun Yu, Shanzhou Huang, Qi Zhou and Binglu Li
    Citation: BMC Cancer 2023 23:404
    Content type: Research Published on:

  2. Leukocyte immunoglobulin-like receptor subfamily B1 (LILRB1) is regarded as an inhibitory molecule. However, the importance of LILRB1 expression in glioma has not yet been determined. This investigation examin...

    Authors: Renheng Zou, Xunlong Zhong, Kairong Liang, Cheng Zhi, Danmin Chen, Zhichao Xu, Jingbai Zhang, Degui Liao, Miaoling Lai, Yuhao Weng, Huaidong Peng, Xiao Pang, Yunxiang Ji, Yanbin Ke, Hongri Zhang, Zhaotao Wang…
    Citation: BMC Cancer 2023 23:403
    Content type: Research Published on:

  3. Lymph node (LN) metastasis is the earliest sign of metastatic spread and an established predictor of poor outcome in gallbladder cancer (GBC). Patients with LN positive GBC have a significantly worse survival ...

    Authors: Vaishali Jain, Javed Akhtar, Ratna Priya, Puja Sakhuja, Surbhi Goyal, Anil Kumar Agarwal, Vivek Ghose, Ravindra Varma Polisetty, Ravi Sirdeshmukh, Fouzia Siraj and Poonam Gautam
    Citation: BMC Cancer 2023 23:402
    Content type: Research Published on:

  4. Endometrial cancer (EC) arises from uterine endometrium tissue and is the most prevalent cancer of the female reproductive tract in developed countries. It has been predicted that the global prevalence of EC w...

    Authors: Fathima Hameed J S, Anjali Devarajan, Devu Priya M S, Ahel Bhattacharyya, Mayur Balkrishna Shirude, Debasree Dutta, Parimal Karmakar and Ananda Mukherjee
    Citation: BMC Cancer 2023 23:399
    Content type: Research Published on:

  6. We aimed to assess the trends in urinary tract infections (UTIs) and prognosis of patients with prostate cancer after radical prostatectomy (RP) and radiation therapy (RT) as definitive treatment options.

    Authors: Jihye Hyun, Moon Soo Ha, Seung Young Oh, Jong Hyun Tae, Byung Hoon Chi, In Ho Chang, Tae-Hyoung Kim, Soon Chul Myung, Tuan Thanh Nguyen, Jung Hoon Kim, Jin Wook Kim, Yong Seong Lee, Jooyoung Lee and Se Young Choi
    Citation: BMC Cancer 2023 23:395
    Content type: Research Published on:

  7. Laparoscopic surgery (LS) has been increasingly applied in perihilar cholangiocarcinoma (pCCA). In this study, we intend to compare the short-term outcomes of LS versus open operation (OP) for pCCA in a multic...

    Authors: Min Wang, Tingting Qin, Hang Zhang, Jingdong Li, Xiaxing Deng, Yuhua Zhang, Wenxing Zhao, Ying Fan, Dewei Li, Xuemin Chen, Yechen Feng, Siwei Zhu, Zhongqiang Xing, Guangsheng Yu, Jian Xu, Junjie Xie…
    Citation: BMC Cancer 2023 23:394
    Content type: Research Published on:

  8. Immunotherapy (IO) has become a standard of care for treating various types of metastatic cancers and has significantly improved clinical outcome. With the exception of metastatic melanoma in complete response...

    Authors: Gwenaelle Gravis, Patricia Marino, Daniel Olive, Frederique Penault-LLorca, Jean-Pierre Delord, Clotilde Simon, Assia Lamrani-Ghaouti, Renaud Sabatier, Joseph Ciccolini and Jean-Marie Boher
    Citation: BMC Cancer 2023 23:393
    Content type: Study Protocol Published on:

  9. Tumor-associated macrophages (TAMs) are the most abundant types of immune cells in the tumor microenvironment (TME) of breast cancer (BC). TAMs usually exhibit an M2 phenotype and promote tumor progression by ...

    Authors: Chongru Zhao, Ning Zeng, Xiaomei Zhou, Yufang Tan, Yichen Wang, Jun Zhang, Yiping Wu and Qi Zhang
    Citation: BMC Cancer 2023 23:392
    Content type: Research Published on:

  10. Patient and clinician reminders were implemented as part of an adherence improvement project at University of Florida (UF) Internal Medicine Clinics. We sought to assess colorectal cancer (CRC) screening compl...

    Authors: Abdillahi M. Ahmed, Michael W. Bacchus, Stacy G. Beal, Katherine N. Huber, Ji-Hyun Lee, Jing Zhao, Thomas J. George and Maryam Sattari
    Citation: BMC Cancer 2023 23:391
    Content type: Research Published on:

  11. Patients undergoing hematopoietic cell transplantation (HCT) are at high risk of chronic health complications, including frailty and physical dysfunction. Conventional exercise programs have been shown to impr...

    Authors: Kyuwan Lee, Justin Shamunee, Lanie Lindenfeld, Elizabeth Ross, Lindsey Hageman, Mina S. Sedrak, F. Lennie Wong, Ryotaro Nakamura, Stephen J. Forman, Smita Bhatia and Saro H. Armenian
    Citation: BMC Cancer 2023 23:390
    Content type: Research Published on:

  12. Interactions between the programmed cell death receptor 1 (PD-1) and its ligand (PD-L1) lead to immune evasion in various tumors and are associated with poor prognosis in patients with pancreatic cancer; howev...

    Authors: Se Jun Park, Ju Yeon Park, Kabsoo Shin, Tae Ho Hong, MyungAh Lee, Younghoon Kim and In-Ho Kim
    Citation: BMC Cancer 2023 23:389
    Content type: Research Published on:

  13. In recent years, there has been growing evidence indicating a relationship between liquid–liquid phase separation (LLPS) and cancer development. However, to date, the clinical significance of LLPS in skin cuta...

    Authors: Jianlan Liu, Shengbin Pei, Pengpeng Zhang, Keyu Jiang, Binlin Luo, Zuoqiong Hou, Gang Yao and Jian Tang
    Citation: BMC Cancer 2023 23:388
    Content type: Research Published on:

  15. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12885-018-4559-3.

    Authors: Xue Hou, Run Gong, Jianhua Zhan, Ting Zhou, Yuxiang Ma, Yuanyuan Zhao, Yaxiong Zhang, Gang Chen, Zhonghan Zhang, Shuxiang Ma, Xi Chen, Fangfang Gao, Shaodong Hong, Fan Luo, Wenfeng Fang, Yunpeng Yang…
    Citation: BMC Cancer 2023 23:386
    Content type: Retraction Note Published on:

  16. A neural network method was employed to establish a dose prediction model for organs at risk (OAR) in patients with cervical cancer receiving brachytherapy using needle insertion.

    Authors: Huai-wen Zhang, Xiao-ming Zhong, Zhen-hua Zhang and Hao-wen Pang
    Citation: BMC Cancer 2023 23:385
    Content type: Research Published on:

  17. There is pressing needs to find the biomarker in the selection of neoadjuvant therapy in postmenopausal luminal breast cancer patients. We examined the hypothesis that PIK3CA mutations and low phosphatase and ten...

    Authors: Shouko Hayama, Rikiya Nakamura, Takayuki Ishige, Takafumi Sangai, Masahiro Sakakibara, Hiroshi Fujimoto, Emi Ishigami, Takahito Masuda, Ayako Nakagawa, Ryotaro Teranaka, Satoshi Ota, Sakae Itoga, Naohito Yamamoto, Takeshi Nagashima and Masayuki Otsuka
    Citation: BMC Cancer 2023 23:384
    Content type: Research Published on:

  18. ERAP1 is a major aminopeptidase that serves as an editor of the peptide repertoire by trimming N-terminal residues of antigenic peptides, creating a pool of peptides with the optimal length for MHC-I binding. ...

    Authors: Marta Wagner, Maciej Sobczyński, Monika Jasek, Konrad Pawełczyk, Irena Porębska, Piotr Kuśnierczyk and Andrzej Wiśniewski
    Citation: BMC Cancer 2023 23:383
    Content type: Research Published on:

  20. 99mTc-MAA accumulation within the tumor representing pulmonary arterial perfusion, which is variable and may have a clinical significance. We evaluated the prognostic significance of 99mTc-MAA distribution within...

    Authors: Vanessa Murad, Minseok Suh, Hongyoon Choi, Gi Jeong Cheon, Kwon Joong Na and Young Tae Kim
    Citation: BMC Cancer 2023 23:381
    Content type: Research Published on:

  21. Dihydropyrimidine dehydrogenase (DPD) is a key enzyme in the metabolism of fluoropyrimidines. Variations in the encoding DPYD gene are associated with severe fluoropyrimidine toxicity and up-front dose reductions...

    Authors: David K. Lau, Caroline Fong, Faten Arouri, Lillian Cortez, Hannah Katifi, Reyes Gonzalez-Exposito, Muhammad Bilal Razzaq, Su Li, Aislinn Macklin-Doherty, Monica Arenas Hernandez, Michael Hubank, Charlotte Fribbens, David Watkins, Sheela Rao, Ian Chau, David Cunningham…
    Citation: BMC Cancer 2023 23:380
    Content type: Research Published on:

  22. Cancers of the head and neck region are often characterized by locally advanced, non-metastatic disease. Standard treatments for advanced cervico-facial cancers of the skin or primary head and neck squamous ce...

    Authors: Justin Lee, Nhu Tram Nguyen, James Wright, Ka-Kit David Yeung, Stephen Sagar, Do-Hoon Kim, Orest Ostapiak, Lilian Doerwald-Munoz and Timothy Whelan
    Citation: BMC Cancer 2023 23:379
    Content type: Study protocol Published on:

  23. Malignant tumors of the biliary system are characterized by a high degree of malignancy and strong invasiveness, and they are usually diagnosed at late stages with poor prognosis. For patients with advanced bi...

    Authors: Yaoqun Wang, Ningyuan Wen, Shaofeng Wang, Guilin Nie, Yuan Tian, Jiong Lu and Bei Li
    Citation: BMC Cancer 2023 23:378
    Content type: Research Published on:

  24. Compelling evidence has indicated a significant association between leukocyte mitochondrial DNA copy number (mtDNAcn) and prognosis of several malignancies in a cancer-specific manner. However, whether leukocy...

    Authors: Wenzhe Zhang, Songping Lin, Bangwei Zeng, Xiaobin Chen, Lili Chen, Minyan Chen, Wenhui Guo, Yuxiang Lin, Liuwen Yu, Jialin Hou, Yan Li, Shengmei Li, Xuan Jin, Weifeng Cai, Kun Zhang, Qian Nie…
    Citation: BMC Cancer 2023 23:377
    Content type: Research Published on:

  26. Adjuvant postoperative treatment with aspirin and statins may improve survival in several solid tumors. This study aimed to assess whether these medications improve the survival after curatively intended treat...

    Authors: Dag Holmberg, Eivind Gottlieb-Vedi, Jakob Hedberg, Mats Lindblad, Fredrik Mattsson and Jesper Lagergren
    Citation: BMC Cancer 2023 23:375
    Content type: Research Published on:

  27. Apoptosis or programmed cell death plays a vital role in maintaining homeostasis and, therefore, is a tightly regulated process. Deregulation of apoptosis signalling can favour carcinogenesis. Apoptosis inhibi...

    Authors: Abhijith Kuttanamkuzhi, Debiprasad Panda, Radhika Malaviya, Gautami Gaidhani and Mayurika Lahiri
    Citation: BMC Cancer 2023 23:374
    Content type: Research Published on:

  28. The cytokine Osteopontin is a mediator of tumor progression and cancer metastasis. In 2006, we reported that (in addition to the full-length form -a) splice variants of Osteopontin (forms -b and -c) are produc...

    Authors: Yu An, Gulimirerouzi Fnu, Changchun Xie and Georg F. Weber
    Citation: BMC Cancer 2023 23:373
    Content type: Research article Published on:

  29. As an essential regulator of type I interferon (IFN) response, TMEM173 participates in immune regulation and cell death induction. In recent studies, activation of TMEM173 has been regarded as a promising stra...

    Authors: Yiqing Cai, Xiaomin Chen, Tiange Lu, Zhuoya Yu, Shunfeng Hu, Jiarui Liu, Xiangxiang Zhou and Xin Wang
    Citation: BMC Cancer 2023 23:372
    Content type: Research Published on:

  30. Insulin-like growth factor binding proteins (IGFBPs) are critical regulators of the biological activities of insulin-like growth factors. The IGFBP family plays diverse roles in different types of cancer, whic...

    Authors: Yingnan Liu, Shixuan Shen, Ziwei Yan, Lirong Yan, Hanxi Ding, Ang Wang, Qian Xu, Liping Sun and Yuan Yuan
    Citation: BMC Cancer 2023 23:371
    Content type: Research Published on:

  31. Lymphovascular invasion (LVI) is a crucial predictor of lymph node metastasis (LNM). However, few studies have investigated the LVI positivity rate and its clinical significance in pT1b esophageal squamous cel...

    Authors: Linxiu Liu, Hua Lin, Guihua Shen, Yong Liu, Xiumin Qin, Yanling Yuan, Bingzhi Wang and Liyan Xue
    Citation: BMC Cancer 2023 23:370
    Content type: Research Published on:

  32. Centre hospitalier de l’Université de Montréal in Canada introduced accompanying patients (APs) into the breast cancer care trajectory. APs are patients who have been treated for breast cancer and have been in...

    Authors: Marie-Pascale Pomey, Monica Iliescu Nelea, Louise Normandin, Cécile Vialaron, Karine Bouchard, Marie-Andrée Côté, Maria Alejandra Rodriguez Duarte, Djahanchah Philip Ghadiri, Israël Fortin, Danielle Charpentier, Mélanie Lavoie-Tremblay, Nicolas Fernandez, Antoine Boivin, Michel Dorval, Mado Desforges, Catherine Régis…
    Citation: BMC Cancer 2023 23:369
    Content type: Research Published on:

  33. Damaging alterations in the BRCA1 gene have been extensively described as one of the main causes of hereditary breast and ovarian cancer (HBOC). BRCA1 alterations can lead to impaired homologous recombination rep...

    Authors: Nicola Bassi, Henrikke Nilsen Hovland, Kashif Rasheed, Elisabeth Jarhelle, Nikara Pedersen, Eunice Kabanyana Mchaina, Sara Marie Engelsvold Bakkan, Nina Iversen, Hildegunn Høberg-Vetti, Bjørn Ivar Haukanes, Per Morten Knappskog, Ingvild Aukrust, Elisabet Ognedal and Marijke Van Ghelue
    Citation: BMC Cancer 2023 23:368
    Content type: Research Published on:

  34. The scavenger receptor CD36 was reported to be highly expressed on tumor-infiltrating CD8+ T cells, but the clinical role remains obscure. This study aims to explore the infiltration and clinical value of CD36+CD...

    Authors: Yong-Qiang Ao, Jian Gao, Ling-Xian Zhang, Jie Deng, Shuai Wang, Miao Lin, Hai-Kun Wang, Jian-Yong Ding and Jia-Hao Jiang
    Citation: BMC Cancer 2023 23:367
    Content type: Research Published on:

  36. In this study, we aimed to investigate the predictive efficacy of magnetic resonance imaging (MRI) radiomics features at different time points of neoadjuvant therapy for rectal cancer in patients with patholog...

    Authors: Jiaxuan Peng, Wei Wang, Hui Jin, Xue Qin, Jie Hou, Zhang Yang and Zhenyu Shu
    Citation: BMC Cancer 2023 23:365
    Content type: Research Published on:

  37. Homo sapiens chromosome 2 clone RP11-339H12 (AC010883.5) is a dysregulated long non-coding RNA (lncRNA) that has never been investigated in cervical cancer (CC). Thus, the potential function and molecular mechani...

    Authors: Qiyu Gan, Xia Huang, Wenrong Zhao, Hui Liu, Yan Xu, Xiaohua Zhang, Jingxin Cheng and Rui Chen
    Citation: BMC Cancer 2023 23:364
    Content type: Research Published on:

  38. Thyroid cancer is the most frequent malignancy of the endocrine system, of which papillary thyroid cancer (PTC) is the predominant form with a rapid increasing incidence worldwide. Rearranged during transfection ...

    Authors: Mengke Chen, Junyu Xue, Ye Sang, Wenting Jiang, Weiman He, Shubin Hong, Weiming Lv, Haipeng Xiao and Rengyun Liu
    Citation: BMC Cancer 2023 23:363
    Content type: Research Published on:

  39. Isolated local failure (ILF) can occur in patients who initially receive definitive radiation therapy for prostate cancer. Salvage therapy for ILF includes high dose rate (HDR) brachytherapy. Prostate Specific...

    Authors: Lucas C. Mendez, Aneesh Dhar, David Laidley, Madeleine Moussa, Jose A. Gomez, Joseph Chin, T-Y Lee, Jonathan D. Thiessen, Douglas Hoover, Kathleen Surrey, Joelle Helou, Vikram Velker, Rohann J. Correa, David D’Souza, Jane Bayani and Glenn Bauman
    Citation: BMC Cancer 2023 23:362
    Content type: Study Protocol Published on:

  40. Severe lymphedema presents a challenge in terms of treatment due to the significant formation of scar tissue that accompanies it. The aim of this study was to identify intraoperative and preoperative risk fact...

    Authors: Xiaozhen Liu, Kewang Sun, Hongjian Yang, Lingli Xia, Kefeng Lu, Xuli Meng and Yongfeng Li
    Citation: BMC Cancer 2023 23:361
    Content type: Research Published on:

  41. Over the past decade, there has been increasing availability of novel therapeutics with improved tolerability and efficacy for advanced non-small cell lung cancer (NSCLC). The study goals were: to compare the ...

    Authors: Bonnie Leung, Aria Shokoohi, Zamzam Al-Hashami, Sara Moore, Alexandra Pender, Selina K. Wong, Ying Wang, Jonn Wu and Cheryl Ho
    Citation: BMC Cancer 2023 23:360
    Content type: Research Published on:

  43. Positron emission tomography and computed tomography (PET-CT) is currently recommended in evaluating the treatment response after (chemo)radiotherapy ([C]RT). In the larynx, post-treatment changes and physiolo...

    Authors: Heli J. Sistonen, Taru Ilmarinen, Timo Atula, Katri Aro, Jukka Schildt and Antti Markkola
    Citation: BMC Cancer 2023 23:358
    Content type: Research Published on:

  44. Polypharmacy is very common in older cancer patients and these patients are particularly vulnerable to drug-drug interactions and adverse drug reactions because they often receive chemotherapy and symptom-reli...

    Authors: Ben Schöttker, Li-Ju Chen, Reiner Caspari and Hermann Brenner
    Citation: BMC Cancer 2023 23:357
    Content type: Study Protocol Published on:

  45. Colorectal cancer (CRC) is the third most prevalent cancer in the world, yet the sensitivity and specificity of biomarkers for CRC diagnosis are insufficient. In the present study, we performed a protein micro...

    Authors: Takahiro Arasawa, Takaki Hiwasa, Akiko Kagaya, Tetsuro Maruyama, Masaya Uesato, Masayuki Kano, Sohei Kobayashi, Hirotaka Takizawa, Katsuro Iwase, Fumio Nomura, Kazuyuki Matsushita and Hisahiro Matsubara
    Citation: BMC Cancer 2023 23:356
    Content type: Research Published on:

  46. Bladder cancer (BC) is one of the most common malignant diseases and the most common causes of cancer death worldwide. Immunotherapy has opened new avenues for precision treatment of bladder tumours, and immun...

    Authors: Pengyu Hui, Feng Ni, Liang Zheng, Lei Jia and Zhe Wang
    Citation: BMC Cancer 2023 23:355
    Content type: Research Published on:

  48. As both life expectancy and cancer survival improve, the incidence of multiple primary cancer has augmented and is expected to further increase. This study describes for the first time the epidemiology of mult...

    Authors: Gilles Macq, Geert Silversmit, Freija Verdoodt and Liesbet Van Eycken
    Citation: BMC Cancer 2023 23:349
    Content type: Research Published on:

  49. Colorectal cancer (CRC) is the fourth and third most common cancer in Iran and the world, respectively. Carbohydrates can lead to the proliferation of cancer cells, including CRC. The current study aimed to in...

    Authors: Masoud Amini Kahrizsangi, Zohreh Ebrahimi, Zainab Shateri, Fatemeh Mansouri, Ali Zangene, Milad Rajabzadeh-Dehkordi, Mehran Nouri and Bahram Rashidkhani
    Citation: BMC Cancer 2023 23:347
    Content type: Research Published on:

  50. Newcastle disease virus (NDV) is an oncolytic virus that can inhibit cancer cell proliferation and kill cancer cells. The NDV nonstructural V protein can regulate viral replication; however, whether the V prot...

    Authors: Zhili Chu, Sihui Yang, Qianru Li, Jianing Shang, Zilong Ren and Feng Ren
    Citation: BMC Cancer 2023 23:346
    Content type: Research Published on:

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