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  1. Central lymph node status in papillary thyroid microcarcinoma (PTMC) plays an important role in treatment decision-making clinically, however, it is not easy to predict central lymph node metastasis (CLNM). Th...

    Authors: Qian-wen Luo, Shan Gao, Xiao Lv, Si-jia Li, Bo-fang Wang, Qing-qing Han, Yun-peng Wang, Quan-lin Guan and Tao Gong
    Citation: BMC Cancer 2022 22:606

    The Correction to this article has been published in BMC Cancer 2022 22:698

  2. Hypomethylation of long interspersed nuclear element 1 (LINE-1) is characteristic of various cancer types, including colorectal cancer (CRC). Malfunction of several factors or alteration of methyl-donor molecu...

    Authors: Krisztina A. Szigeti, Alexandra Kalmár, Orsolya Galamb, Gábor Valcz, Barbara K. Barták, Zsófia B. Nagy, Sára Zsigrai, Ildikó Felletár, Árpád V. Patai, Tamás Micsik, Márton Papp, Eszter Márkus, Zsolt Tulassay, Peter Igaz, István Takács and Béla Molnár
    Citation: BMC Cancer 2022 22:605
  3. With the aim of obtaining more uniformity and quality in the treatment of corpus uteri cancer in Belgium, the EFFECT project has prospectively collected detailed information on the real-world clinical care off...

    Authors: Joren Vanbraband, Nancy Van Damme, Gauthier Bouche, Geert Silversmit, Anke De Geyndt, Eric de Jonge, Gerd Jacomen, Frédéric Goffin, Hannelore Denys and Frédéric Amant
    Citation: BMC Cancer 2022 22:600
  4. The full-length BRCA1-associated RING domain 1 (BARD1) gene encodes a 777-aa protein. BARD1 displays a dual role in cancer development and progression as it acts as a tumor suppressor and an oncogene. Structur...

    Authors: Yousef M. Hawsawi, Anwar Shams, Abdulrahman Theyab, Wed A. Abdali, Nahed A. Hussien, Hanan E. Alatwi, Othman R. Alzahrani, Atif Abdulwahab A. Oyouni, Ahmad O. Babalghith and Mousa Alreshidi
    Citation: BMC Cancer 2022 22:599
  5. Tumor heterogeneity has frequently been observed in gastric cancer (GC), but the correlation between patients’ clinico-pathologic features and the tumoral heterogeneity of GC-associated molecules is unclear. W...

    Authors: Gen Tsujio, Koji Maruo, Yurie Yamamoto, Tomohiro Sera, Atsushi Sugimoto, Hiroaki Kasashima, Yuichiro Miki, Mami Yoshii, Tatsuro Tamura, Takahiro Toyokawa, Hiroaki Tanaka, Kazuya Muguruma, Masaichi Ohira and Masakazu Yashiro
    Citation: BMC Cancer 2022 22:598
  6. Osimertinib is a standard first-line treatment for advanced non-small-cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations. Although malignant pleural effusion (PE) is a common cli...

    Authors: Hiroshi Nokihara, Hirokazu Ogino, Atsushi Mitsuhashi, Kensuke Kondo, Ei Ogawa, Ryohiko Ozaki, Yohei Yabuki, Hiroto Yoneda, Kenji Otsuka and Yasuhiko Nishioka
    Citation: BMC Cancer 2022 22:597
  7. Part of papillary thyroid microcarcinoma (PTMC) has a high risk of tumor invasion and metastasis, which may occur in the regional lymph node metastasis or distant metastasis, severely threatening the life of p...

    Authors: Xiuhe Zou, Qian Zhou, Yan Nie, Junhe Gou, Jing Yang, Jingqiang Zhu, Zhihui Li and Yanping Gong
    Citation: BMC Cancer 2022 22:595
  8. NOSTRIN, abundantly expressed in colon, was reported to be anti-angiogenic, anti-invasive and anti-inflammatory. NOSTRIN expression was inversely related to survival of pancreatic ductal adeno-carcinoma patien...

    Authors: Madhurima Paul, Tamal Kanti Gope, Priyanka Das and Rupasri Ain
    Citation: BMC Cancer 2022 22:594
  9. Prior studies reported survival benefits from early initiation of adjuvant chemotherapy for stage III colon cancer, but this evidence was derived from studies that may be sensitive to time-related biases. Ther...

    Authors: Yan Lu, Aaron W. Gehr, Rachel J. Meadows, Bassam Ghabach, Latha Neerukonda, Kalyani Narra and Rohit P. Ojha
    Citation: BMC Cancer 2022 22:593
  10. Due to the fast growing relapsed/refractory multiple myeloma (RRMM) treatment landscape, a comparison of all the available treatments was warranted. For clinical practice it is important to consider both immed...

    Authors: Chrissy H. Y. van Beurden-Tan, Pieter Sonneveld and Carin A. Uyl-de Groot
    Citation: BMC Cancer 2022 22:591
  11. The aim of the study was to enhance colorectal cancer prognostication by integrating single nucleotide polymorphism (SNP) and gene expression (GE) microarrays for genomic and transcriptional alteration detecti...

    Authors: Ming-Hung Shen, Chi-Jung Huang, Thien-Fiew Ho, Chih-Yi Liu, Ying-Yih Shih, Ching-Shui Huang and Chi-Cheng Huang
    Citation: BMC Cancer 2022 22:590
  12. Cystatins are a class of proteins that can inhibit cysteine protease and are widely distributed in human bodily fluids and secretions. Cystatin SN (CST1), a member of the CST superfamily, is abnormally express...

    Authors: Jian Yang, Gaomeng Luo, Chang Li, Zhunlin Zhao, Sheng Ju, Qifan Li, Zhike Chen, Cheng Ding, Xin Tong and Jun Zhao
    Citation: BMC Cancer 2022 22:589
  13. The international consensus guidelines for intraductal papillary mucinous neoplasm of the pancreas (IPMN) presented clinical features as indications for surgery. Whereas surveillance for recurrence, including ...

    Authors: Tomokazu Fuji, Yuzo Umeda, Kosei Takagi, Ryuichi Yoshida, Kazuhiro Yoshida, Kazuya Yasui, Kazuyuki Matsumoto, Hironari Kato, Takahito Yagi and Toshiyoshi Fujiwara
    Citation: BMC Cancer 2022 22:588
  14. With the introduction of DNA-damaging therapies into standard of care cancer treatment, there is a growing need for predictive diagnostics assessing homologous recombination deficiency (HRD) status across tumo...

    Authors: Benjamin D. Leibowitz, Bonnie V. Dougherty, Joshua S. K. Bell, Joshuah Kapilivsky, Jackson Michuda, Andrew J. Sedgewick, Wesley A. Munson, Tushar A. Chandra, Jonathan R. Dry, Nike Beaubier, Catherine Igartua and Timothy Taxter
    Citation: BMC Cancer 2022 22:587
  15. Although with the impressive efficacy, several patients showed intrinsic resistance or an unsatisfactory response to Osimertinib. We aim to explore the impact of clinical and molecular features on efficacy and...

    Authors: Ying Jin, Chen Lin, Xun Shi, Qiong He, Junrong Yan, Xinmin Yu and Ming Chen
    Citation: BMC Cancer 2022 22:586
  16. B7 molecules play significant roles in regulating tumor immunity, but their expression patterns and immuno-biological correlations in pancreatic cancer (PaCa) have not been fully discussed.

    Authors: Jiayue Yang, Zhen Tian, Han Gao, Fan Xiong, Cuiping Cao, Jiaojiao Yu, Wei Shi, Qiang Zhan and Cheng Yang
    Citation: BMC Cancer 2022 22:584
  17. This study aimed to propose a new user-friendly, cost effective and robust risk model to facilitate risk stratification for diffuse large B-cell lymphoma (DLBCL) treated with frontline R-CHOP regimens.

    Authors: Haizhu Chen, Qiaofeng Zhong, Yu Zhou, Yan Qin, Jianliang Yang, Peng Liu, Xiaohui He, Shengyu Zhou, Changgong Zhang, Lin Gui, Sheng Yang, Liqiang Zhou and Yuankai Shi
    Citation: BMC Cancer 2022 22:583
  18. At present, “Belt and Road” (“B&R”) member states (accounting for about 61.78% of the world’s population) face different types of cancer threats to varying degrees. We analyzed the incidence and mortality and ...

    Authors: Baohua Wang, Fengdie He, Yanan Hu, Qiutong Wang, Dan Wang, Yuting Sha and Jing Wu
    Citation: BMC Cancer 2022 22:582
  19. Long non-coding RNA P73 antisense RNA 1 T (non-protein coding), also known as Lnc RNA TP73-AS1, is dysregulated in various tumors but the correlation between its expression and clinicopathological parameters a...

    Authors: Caizhi Chen, Jingjing Wang, Yeqian Feng, Ye Liang, Yan Huang and Wen Zou
    Citation: BMC Cancer 2022 22:581
  20. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) provide a better prognosis in EGFR-mutant non-small cell lung cancer (NSCLC). Nevertheless, the outcome of leptomeningeal metastasis (LM) re...

    Authors: Hainan Yang, Lei Wen, Yingying Pan, Changguo Shan, Weiping Hong, Hui Wang, Cheng Zhou, Linbo Cai and Caicun Zhou
    Citation: BMC Cancer 2022 22:580
  21. The ideal extent of lymphadenectomy (LAD) in esophageal oncological surgery is debated. There is no evidence for improved survival after standardized paratracheal lymph node resection performing oncological es...

    Authors: C. Mann, F. Berlth, E. Hadzijusufovic, E. Tagkalos, E. Uzun, C. Codony, H. Lang and P. P. Grimminger
    Citation: BMC Cancer 2022 22:579
  22. High-mobility group box 1 (HMGB1) is increased in breast cancer cells as the result of exposure to the secreted substances from cancer-associated fibroblasts and plays a crucial role in cancer progression and ...

    Authors: Kamolporn Amornsupak, Suyanee Thongchot, Chanida Thinyakul, Carol Box, Somaieh Hedayat, Peti Thuwajit, Suzanne A. Eccles and Chanitra Thuwajit
    Citation: BMC Cancer 2022 22:578
  23. Advanced non-squamous non-small cell lung cancer (NS-NSCLC) patients without driver gene mutations are usually treated with immune checkpoint inhibitors (ICIs) plus pemetrexed as maintenance therapy after firs...

    Authors: Xiaodong Gu, Zhiyong Shi, Lan Shao, Yuxin Zhang, Yiping Zhang, Zhengbo Song, Wenxian Wang and Guangyuan Lou
    Citation: BMC Cancer 2022 22:576
  24. Some cancers such as sarcomas (bone and soft tissue sarcomas) and adenoid cystic carcinomas are considered as radioresistant to low linear energy transfer radiation (including photons and protons) and may ther...

    Authors: Jacques Balosso, Olivia Febvey-Combes, Annie Iung, Hélène Lozano, Abdoulkader Soumai Alloh, Catherine Cornu, Magali Hervé, Zohra Akkal, Michel Lièvre, Valérie Plattner, Francesca Valvo, Cristina Bono, Maria Rosaria Fiore, Viviana Vitolo, Barbara Vischioni, Stéphanie Patin…
    Citation: BMC Cancer 2022 22:575
  25. Non-specific symptoms are  common and often sign of a non-serious disease. Because of this, patients with non-specific symptoms of cancer (NSSC) present a challenge for general practitioners (GP). Studies desc...

    Authors: Ellen Jensen, Jette Kolding Kristensen, Rikke Tveden Bjerglund, Søren Paaske Johnsen and Janus Laust Thomsen
    Citation: BMC Cancer 2022 22:574
  26. Extracellular vesicle (EV) biomarkers have promising diagnosis and screening capacity for several cancers, but the diagnostic value for pancreatic cancer (PC) is controversial. The aim of our study was to revi...

    Authors: Erna Jia, Na Ren, Xianquan Shi, Rongkui Zhang, Haixin Yu, Fan Yu, Shaoyou Qin and Jinru Xue
    Citation: BMC Cancer 2022 22:573
  27. Post-translational modification plays an important role in the occurrence and development of various tumors. However, few researches were focusing on the SUMOylation regulatory genes as tumor biomarkers to pre...

    Authors: Hongxu Sheng, Zhexue Hao, Linhai Zhu, Yuan Zeng and Jianxing He
    Citation: BMC Cancer 2022 22:572
  28. The addition of anti-angiogenesis drugs to epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitor (TKI) or chemotherapy in patients with EGFR-mutant non–small cell lung cancer (NSCLC) can improve di...

    Authors: Chieh-Lung Chen, Sing-Ting Wang, Wei-Chih Liao, Chia-Hung Chen, Chih-Yen Tu, Hung-Jen Chen, Te-Chun Hsia and Wen-Chien Cheng
    Citation: BMC Cancer 2022 22:571
  29. To develop and validate a nebulizer device for anti-cancer research on pressurized intraperitoneal aerosol supply in a preclinical peritoneal metastases (PM) rat model.

    Authors: Jonathan R. Buggisch, Daniel Göhler, Julien Sobilo, Stéphanie Lerondel, Günther A. Rezniczek, Michael Stintz, Andreas Rudolph, Nicolas Tabchouri, Sébastien Roger, Mehdi Ouaissi and Urs Giger-Pabst
    Citation: BMC Cancer 2022 22:570
  30. This report summarizes three phase I studies evaluating volasertib, a polo-like kinase inhibitor, plus azacitidine in adults with myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia, or acute myel...

    Authors: Uwe Platzbecker, Joerg Chromik, Jan Krönke, Hiroshi Handa, Stephen Strickland, Yasushi Miyazaki, Martin Wermke, Wataru Sakamoto, Yoshifumi Tachibana, Tillmann Taube and Ulrich Germing
    Citation: BMC Cancer 2022 22:569
  31. Cadherin-23 (CDH23) plays an important role in intercellular adhesion and is involved in the progression of several types of cancer. However, the biological functions and effect of CDH23 expression on the prog...

    Authors: Jiao Yang, Fei Lu, Guangxin Ma, Yihua Pang, Yanan Zhao, Tao Sun, Daoxin Ma, Jingjing Ye and Chunyan Ji
    Citation: BMC Cancer 2022 22:568
  32. The uncontrolled proliferation of cancer cells determines hypoxic conditions within the neoplastic mass with consequent activation of specific molecular pathways that allow cells to survive despite oxygen depr...

    Authors: Chiara Zichittella, Maria Magdalena Barreca, Aurora Cordaro, Chiara Corrado, Riccardo Alessandro and Alice Conigliaro
    Citation: BMC Cancer 2022 22:567
  33. The role of Berberine (BBR) in colorectal cancer (CRC) and gut microbiota has begun to appreciate. However, there was no direct evidence confirm that the gut microbiota regulated by BBR could inhibit CRC. This...

    Authors: Haitao Chen, Chenxiao Ye, Biyu Cai, Fan Zhang, Xuanying Wang, Jin Zhang, Zewei Zhang, Yong Guo and Qinghua Yao
    Citation: BMC Cancer 2022 22:566
  34. Anti-programmed cell death receptor-1 (PD-1) monotherapy is the standard treatment for metastatic melanoma in current. Camrelizumab is a humanized IgG4 anti-PD-1 monoclonal antibody whose safety and efficacy h...

    Authors: Li Zhou, Xiaowen Wu, Zhihong Chi, Lu Si, Xinan Sheng, Yan Kong, Lili Mao, Bin Lian, Bixia Tang, Xieqiao Yan, Xuan Wang, Xue Bai, Siming Li, Xiaoting Wei, Juan Li, Qing Yang…
    Citation: BMC Cancer 2022 22:565
  35. Ribosomal protein S6 (S6), a downstream effect media of the AKT/mTOR pathway, not only is a part of 40S small subunit of eukaryotic ribosome, but also involves in protein synthesis and cell proliferation durin...

    Authors: Yaoxiang Tang, Jiadi Luo, Ying Zhou, Hongjing Zang, Yang Yang, Sile Liu, Hongmei Zheng, Jian Ma, Songqing Fan and Qiuyuan Wen
    Citation: BMC Cancer 2022 22:564
  36. Metastatic pancreatic cancer (mPC) and its treatments significantly impact health-related quality of life (HRQoL). POLO, a randomized, double-blind, placebo-controlled phase 3 trial evaluated the efficacy of o...

    Authors: Suvina Amin, Seongjung Joo, Sandra Nolte, Hyun Kyoo Yoo, Nikunj Patel, Hilary F. Byrnes, Sara Costa-Cabral and Colin D. Johnson
    Citation: BMC Cancer 2022 22:563
  37. Studies have shown that DAB2IP inhibits cancer progression, while HSP90AA1 promotes cancer progression. However, the specific regulatory mechanism of DAB2IP and HSP90AA1 in colorectal cancer (CRC) is not clear...

    Authors: Mengna Zhang, Yanan Peng, Zhenwei Yang, Hailin Zhang, Cong Xu, Lan Liu, Qiu Zhao, Jixiong Wu, Hongling Wang and Jing Liu
    Citation: BMC Cancer 2022 22:561
  38. Given the psychosocial burdens patients in advanced stages of cancer face, innovative care concepts are needed. At the same time, such vulnerable patient groups are difficult to reach for participation in inte...

    Authors: Johann Frick, Pimrapat Gebert, Ulrike Grittner, Anne Letsch, Daniel Schindel and Liane Schenk
    Citation: BMC Cancer 2022 22:560
  39. Laminins are high-molecular weight (400 ~ 900 kDa) proteins in extracellular matrix, which serve as major component of the basal lamina, and play a crucial role in promoting tumor cell migration. This study ai...

    Authors: Nan Hao, Daming Yang, Tianpei Liu, Shucheng Liu, Xinsheng Lu and Libo Chen
    Citation: BMC Cancer 2022 22:558
  40. Chemokines are highly expressed in tumor microenvironment and play a critical role in all aspects of tumorigenesis, including the recruitment of tumor-promoting immune cells, activation of cancer-associated fi...

    Authors: Sarah Johnson, Yaroslava Karpova, Danping Guo, Atreyi Ghatak, Dmitriy A. Markov and Alexei V. Tulin
    Citation: BMC Cancer 2022 22:557
  41. The bifunctional methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (MTHFD2) has been reported to play an oncogenic role in various types of cancers. However, the...

    Authors: Lin Zhu, Xianhui Liu, Weiyu Zhang, Hao Hu, Qi Wang and Kexin Xu
    Citation: BMC Cancer 2022 22:556
  42. It is known that geographic location plays a role in developing lung cancer. The objectives of this study were to examine spatio-temporal patterns of lung cancer incidence in Pennsylvania, to identify geograph...

    Authors: Nuria Camiña, Tara L. McWilliams, Thomas P. McKeon, Trevor M. Penning and Wei-Ting Hwang
    Citation: BMC Cancer 2022 22:555
  43. While prostate cancer (PCa) cells most often metastasize to bone in men, species-specific differences between human and mouse bone marrow mean that this pattern is not faithfully replicated in mice. Herein we ...

    Authors: Bianca Nowlan, Elizabeth D. Williams and Michael Robert Doran
    Citation: BMC Cancer 2022 22:554
  44. Immune-mediated pneumonitis has a high mortality rate; however, information regarding the related risk factors remains limited. This study aimed to analyze risk factors for pneumonitis, including smoking and l...

    Authors: Yasuki Uchida, Daisuke Kinose, Yukihiro Nagatani, Sachiko Tanaka-Mizuno, Hiroaki Nakagawa, Kentaro Fukunaga, Masafumi Yamaguchi and Yasutaka Nakano
    Citation: BMC Cancer 2022 22:551

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