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  1. Head and neck cancer is an important cause of ill health. Survival appears to be improving but the reasons for this are unclear. They could include evolving aetiology, modifications in care, improvements in tr...

    Authors: Andrew Robert Ness, Andrea Waylen, Katrina Hurley, Mona Jeffreys, Chris Penfold, Miranda Pring, Sam Leary, Christine Allmark, Stu Toms, Susan Ring, Tim J Peters, Will Hollingworth, Helen Worthington, Chris Nutting, Sheila Fisher, Simon N Rogers…
    Citation: BMC Cancer 2014 14:973
    Content type: Study protocol Published on:

  2. Numerous attempts have been made to establish and develop tumor markers that could determine the susceptibility of normal tissues to transform into cancerous ones. To determine whether altered expression patte...

    Authors: Sandra Ventorin von Zeidler, Talitha de Souza Botelho, Elismauro Francisco Mendonça and Aline Carvalho Batista
    Citation: BMC Cancer 2014 14:972
    Content type: Research article Published on:

  3. Treatment of cancer in the lung in octogenarians is limited by their health and functional status. Stereotactic ablative radiotherapy is an established noninvasive treatment option for medically inoperable pat...

    Authors: Nathan A Cannon, Puneeth Iyengar, Hak Choy, Robert Timmerman and Jeffrey Meyer
    Citation: BMC Cancer 2014 14:971
    Content type: Research article Published on:

  4. We recently published PROGgene, a tool that can be used to study prognostic implications of genes in various cancers. The first version of the tool had several areas for improvement. In this paper we present s...

    Authors: Chirayu Pankaj Goswami and Harikrishna Nakshatri
    Citation: BMC Cancer 2014 14:970
    Content type: Software Published on:

  5. Tumor debulking surgery followed by adjuvant chemotherapy or radiotherapy is a standard treatment for many solid malignancies. Although this approach can be effective, it often has limited success against recu...

    Authors: Andrea Khong, Amanda L Cleaver, Muhammad Fahmi Alatas, Ben C Wylie, Theresa Connor, Scott A Fisher, Steve Broomfield, Willem J Lesterhuis, Andrew J Currie, Richard A Lake and Bruce W Robinson
    Citation: BMC Cancer 2014 14:969
    Content type: Research article Published on:

  6. Infection with human papillomavirus (HPV) is necessary for the development of cervical carcinoma. By contrast, the role of HPV in the pathogenesis of other malignancies, such as head and neck cancers, is less ...

    Authors: Seye Abogunrin, Gian Luca Di Tanna, Sam Keeping, Stuart Carroll and Ike Iheanacho
    Citation: BMC Cancer 2014 14:968
    Content type: Research article Published on:

  7. Although Muscle Invasive Bladder Cancer (MIBC) is increasing in incidence, treatment has largely remained limited to radical cystectomy with or without cisplatin-based neoadjuvant and/or adjuvant chemotherapy....

    Authors: Vishal Vashistha, David I Quinn, Tanya B Dorff and Siamak Daneshmand
    Citation: BMC Cancer 2014 14:966
    Content type: Research article Published on:

  8. DEK is a transcription factor involved in stabilization of heterochromatin and cruciform structures. It plays an important role in development and progression of different types of cancer. This study aims to a...

    Authors: Javier Martinez-Useros, Maria Rodriguez-Remirez, Aurea Borrero-Palacios, Irene Moreno, Arancha Cebrian, Teresa Gomez del Pulgar, Laura del Puerto-Nevado, Ricardo Vega-Bravo, Alberto Puime-Otin, Nuria Perez, Sandra Zazo, Clara Senin, Maria J Fernandez-Aceñero, Maria S Soengas, Federico Rojo and Jesus Garcia-Foncillas
    Citation: BMC Cancer 2014 14:965
    Content type: Research article Published on:

  9. Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor that acts against receptors for vascular endothelial growth factor and platelet-derived growth factor. Common toxicities of sunitinib treatment ...

    Authors: Yuji Miura, Chiyo K Imamura, Koya Fukunaga, Yoshihiko Katsuyama, Koichi Suyama, Toshikazu Okaneya, Taisei Mushiroda, Yuichi Ando, Toshimi Takano and Yusuke Tanigawara
    Citation: BMC Cancer 2014 14:964
    Content type: Case report Published on:

  10. Mixed phenotype acute leukemias (MPAL) include acute leukemias with blasts that express antigens of more than one lineage, with no clear evidence of myeloid or lymphoid lineage differentiation. T/myeloid (T/My...

    Authors: Giuseppina Tota, Nicoletta Coccaro, Antonella Zagaria, Luisa Anelli, Paola Casieri, Angelo Cellamare, Angela Minervini, Crescenzio Francesco Minervini, Claudia Brunetti, Luciana Impera, Paola Carluccio, Cosimo Cumbo, Giorgina Specchia and Francesco Albano
    Citation: BMC Cancer 2014 14:963
    Content type: Case report Published on:

  11. Uveal melanoma is a tumour arising from melanocytes of the eye, and 30 per cent of these patients develop liver metastases. Exosomes are small RNA containing nano-vesicles released by most cells, including mal...

    Authors: Maria Eldh, Roger Olofsson Bagge, Cecilia Lässer, Joar Svanvik, Margareta Sjöstrand, Jan Mattsson, Per Lindnér, Dong-Sic Choi, Yong Song Gho and Jan Lötvall
    Citation: BMC Cancer 2014 14:962
    Content type: Research article Published on:

  12. Annexin A1 (ANXA1), a 37 kDa multifunctional protein, is over-expressed in tissues from patients of pancreatic carcinoma (PC) where the protein seems to be associated with malignant transformation and poor pro...

    Authors: Raffaella Belvedere, Valentina Bizzarro, Ada Popolo, Fabrizio Dal Piaz, Michele Vasaturo, Paola Picardi, Luca Parente and Antonello Petrella
    Citation: BMC Cancer 2014 14:961
    Content type: Research article Published on:

  13. This is an international study across four European countries (Belgium[BE], the Netherlands[NL], Italy[IT] and Spain[ES]) between 2009 and 2011, describing and comparing care and care setting transitions provi...

    Authors: Winne Ko, Luc Deliens, Guido Miccinesi, Francesco Giusti, Sarah Moreels, Gé A Donker, Bregje Onwuteaka-Philipsen, Oscar Zurriaga, Aurora López-Maside and Lieve Van den Block
    Citation: BMC Cancer 2014 14:960
    Content type: Research article Published on:

  14. Metalloproteinases (MMPs) and their tissue inhibitors of metalloproteinases (TIMPs) are involved in several key pathways of tumor growth, invasion and metastasis, but little is known about their expression acc...

    Authors: Ga-Eon Kim, Ji Shin Lee, Yoo-Duk Choi, Kyung-Hwa Lee, Jae Hyuk Lee, Jong Hee Nam, Chan Choi, Sung Sun Kim, Min Ho Park, Jung Han Yoon and Sun-Seog Kweon
    Citation: BMC Cancer 2014 14:959
    Content type: Research article Published on:

  15. Breast cancer is a heterogeneous disease displaying distinct molecular features and clinical outcome. The molecular profile of triple-negative breast cancers (TNBCs) overlaps with that of basal-like breast can...

    Authors: Kai Doberstein, Karin Milde-Langosch, Niko P Bretz, Uwe Schirmer, Ayelet Harari, Isabell Witzel, Alon Ben-Arie, Michael Hubalek, Elisabeth Müller-Holzner, Susanne Reinold, Alain G Zeimet, Peter Altevogt and Mina Fogel
    Citation: BMC Cancer 2014 14:958
    Content type: Research article Published on:

  16. NKG2D (natural killer group 2, member D) is thought to play an important role in mediating the activation of anticancer immune response. Expression of NKG2D ligands (NKG2DLs) is pronounced in malignancies and ...

    Authors: Hanbyoul Cho, Joon-Yong Chung, Sunghoon Kim, Till Braunschweig, Tae Heung Kang, Jennie Kim, Eun Joo Chung, Stephen M Hewitt and Jae-Hoon Kim
    Citation: BMC Cancer 2014 14:957
    Content type: Research article Published on:

  17. Our previous studies found the high prevalence of depression and anxiety among Chinese cancer patients, and many empirical studies have been conducted to evaluate the effects of psychological interventions on ...

    Authors: Yi-Long Yang, Guo-Yuan Sui, Guang-Cong Liu, De-Sheng Huang, Si-Meng Wang and Lie Wang
    Citation: BMC Cancer 2014 14:956
    Content type: Research article Published on:

  18. Cancer-associated fibroblasts and high mobility group box 1 (HMGB1) protein have been suggested to mediate cancer progression and chemotherapy resistance. The role of such fibroblasts in HMGB1 production in br...

    Authors: Kamolporn Amornsupak, Tonkla Insawang, Peti Thuwajit, Pornchai O-Charoenrat, Suzanne A Eccles and Chanitra Thuwajit
    Citation: BMC Cancer 2014 14:955
    Content type: Research article Published on:

  19. Neoadjuvant Chemotherapy (NC) including trastuzumab induces a high rate of pathological Complete Responses (pCR) in patients with locally advanced HER2-overexpressing Breast Cancer (BC), but is penalized by a ...

    Authors: Gianmaria Miolo, Elena Muraro, Debora Martorelli, Davide Lombardi, Simona Scalone, Simon Spazzapan, Samuele Massarut, Tiziana Perin, Elda Viel, Elisa Comaro, Renato Talamini, Ettore Bidoli, Elisa Turchet, Diana Crivellari and Riccardo Dolcetti
    Citation: BMC Cancer 2014 14:954
    Content type: Research article Published on:

  20. The IFCT-GFPC 0502 phase III study reported prolongation of progression-free survival with gemcitabine or erlotinib maintenance vs. observation after cisplatin–gemcitabine induction chemotherapy for advanced non-...

    Authors: Isabelle Borget, Maurice Pérol, David Pérol, Armelle Lavolé, Laurent Greillier, Pascal Dô, Virginie Westeel, Jacky Crequit, Hervé Léna, Isabelle Monnet, Hervé Le Caer, Pierre Fournel, Lionel Falchero, Michel Poudenx, Fabien Vaylet, Sylvie Chabaud…
    Citation: BMC Cancer 2014 14:953
    Content type: Research article Published on:

  21. Cyclooxygenases (COX) play a key role in prostaglandin metabolism and are important for tumor development and progression. The aim of this study was to analyze the prognostic impact of COX-2 expression in a co...

    Authors: Isabel Sicking, Karlien Rommens, Marco J Battista, Daniel Böhm, Susanne Gebhard, Antje Lebrecht, Cristina Cotarelo, Gerald Hoffmann, Jan G Hengstler and Marcus Schmidt
    Citation: BMC Cancer 2014 14:952
    Content type: Research article Published on:

  22. Cdk1 (cyclin-dependent kinase 1) is critical regulator of the G2-M checkpoint. Cyclin-dependent kinase pathways are considered possible targets for cancer treatment; however, the prognostic role of Cdk1 in col...

    Authors: Wen-Wei Sung, Yueh-Min Lin, Pei-Ru Wu, Hsu-Heng Yen, Hung-Wen Lai, Tzu-Cheng Su, Ren-Hung Huang, Chun-Kai Wen, Chia-Yu Chen, Chih-Jung Chen and Kun-Tu Yeh
    Citation: BMC Cancer 2014 14:951
    Content type: Research article Published on:

  23. HIF-1 (hypoxia-inducible factor 1) is a transcriptional activator that functions as a critical regulator of oxygen homeostasis. Recently, a large number of epidemiological studies have investigated the relatio...

    Authors: Qing Yan, Pin Chen, Songtao Wang, Ning Liu, Peng Zhao and Aihua Gu
    Citation: BMC Cancer 2014 14:950
    Content type: Research article Published on:

  24. Inhibition of metastasis through upregulation of immune surveillance is a major purpose of chemokine gene therapy. In this study, we focused on a membrane-bound chemokine CXCL16, which has shown a correlation ...

    Authors: Ji-Ye Kee, Aya Ito, Shozo Hojo, Isaya Hashimoto, Yoshiko Igarashi, Koichi Tsuneyama, Kazuhiro Tsukada, Tatsuro Irimura, Naotoshi Shibahara, Ichiro Takasaki, Akiko Inujima, Takashi Nakayama, Osamu Yoshie, Hiroaki Sakurai, Ikuo Saiki and Keiichi Koizumi
    Citation: BMC Cancer 2014 14:949
    Content type: Research article Published on:

  25. The value of adjuvant chemotherapy in colorectal cancer is well studied, and guidelines have been established. Little is known about how treatment guidelines are implemented in the everyday clinical setting.

    Authors: Elinor Bexe Lindskog, Katrín Ásta Gunnarsdóttir, Kristoffer Derwinger, Yvonne Wettergren, Bengt Glimelius and Karl Kodeda
    Citation: BMC Cancer 2014 14:948
    Content type: Research article Published on:

  26. The aim of this multicenter, retrospective study was to evaluate the efficacy and safety of metronomic oral cyclophosphamide (MOC) in heavily treated, relapsed ovarian cancer (ROC) patients.

    Authors: Gabriella Ferrandina, Giacomo Corrado, Floriana Mascilini, Paola Malaguti, Riccardo Samaritani, Mariagrazia Distefano, Valeria Masciullo, Alessia Di Legge, Antonella Savarese and Giovanni Scambia
    Citation: BMC Cancer 2014 14:947
    Content type: Research article Published on:

  27. Sarcoid-like reaction is often seen in various types of carcinoma, not only in the primary tumor, but also in regional lymph nodes, and can occur at any time, not only at the time of diagnosis, but also after ...

    Authors: Yota Kawasaki, Kosei Maemura, Hiroshi Kurahara, Yuko Mataki, Satoshi Iino, Masahiko Sakoda, Shinichi Ueno, Hiroyuki Shinchi, Sonshin Takao and Shoji Natsugoe
    Citation: BMC Cancer 2014 14:946
    Content type: Case report Published on:

  29. MYC family members are among the most frequently deregulated oncogenes in human cancers, yet direct therapeutic targeting of MYC in cancer has been challenging thus far. Synthetic lethality provides an opportu...

    Authors: Zongxiang Zhou, Manishha Patel, Nicholas Ng, Mindy H Hsieh, Anthony P Orth, John R Walker, Serge Batalov, Jennifer L Harris and Jun Liu
    Citation: BMC Cancer 2014 14:944
    Content type: Research article Published on:

  30. Smoke-free policies shown to reduce population exposure to secondhand smoke (SHS) are the norm in hospitals in many countries around the world. Armenia, a transition economy in the South Caucasus, has one of t...

    Authors: Narine K Movsisyan, Varduhi Petrosyan, Arusyak Harutyunyan, Diana Petrosyan and Frances Stillman
    Citation: BMC Cancer 2014 14:943
    Content type: Research article Published on:

  31. Breast cancer is a complex multifactorial genetic disease. Among other factors, race and, to an even greater extent, viruses are known to influence the development of this heterogeneous disease. It has been re...

    Authors: Alberto Cedro-Tanda, Alejandro Córdova-Solis, Teresa Juárez-Cedillo, Emmanuel Pina-Jiménez, Marta E Hernández-Caballero, Christian Moctezuma-Meza, Germán Castelazo-Rico, Alejandro Gómez-Delgado, Alejandro Cruz Monsalvo-Reyes, Fabio A Salamanca-Gómez, Diego J Arenas-Aranda and Normand García-Hernández
    Citation: BMC Cancer 2014 14:942
    Content type: Research article Published on:

  32. The aims of this study were to characterize the metabolite profiles of triple negative breast cancer (TNBC) and to investigate the metabolite profiles associated with human epidermal growth factor receptor-2/n...

    Authors: Maria D Cao, Santosh Lamichhane, Steinar Lundgren, Anna Bofin, Hans Fjøsne, Guro F Giskeødegård and Tone F Bathen
    Citation: BMC Cancer 2014 14:941
    Content type: Research article Published on:

  33. Real-world evidence lacks for clinical effectiveness and clinical toxicity associated with platinum-based doublets in the first-line setting for advanced non-squamous non-small cell lung cancer (advNS-NSCLC) i...

    Authors: Yan Wang, Jianhua Chen, Shengqi Wu, Chenping Hu, Xiaoling Li, Yuqin Wang, Yicheng Yang, Narayan Rajan, Yun Chen, Yi Chen, Zhuanzhuan Luo and Wendong Chen
    Citation: BMC Cancer 2014 14:940
    Content type: Research article Published on:

  34. Prostate cancer is the second leading cause of male cancer death in developed countries. Although the role of angiogenesis in its progression is well established, the efficacy of anti-angiogenic therapy is not...

    Authors: Alessandra Fiorio Pla, Alessia Brossa, Michela Bernardini, Tullio Genova, Guillaume Grolez, Arnaud Villers, Xavier Leroy, Natalia Prevarskaya, Dimitra Gkika and Benedetta Bussolati
    Citation: BMC Cancer 2014 14:939
    Content type: Research article Published on:

  35. Fibulin-5 has been considered as a tumor suppressor through inhibiting tumor growth and invasion. Reduced expression of Fibulin-5 is frequently observed in various human cancers. In this study, we investigate ...

    Authors: Kangsheng Tu, Changwei Dou, Xin Zheng, Chao Li, Wei Yang, Yingmin Yao and Qingguang Liu
    Citation: BMC Cancer 2014 14:938
    Content type: Research article Published on:

  36. In patients with ovarian cancer relapsing at least 6 months after end of primary treatment, the addition of paclitaxel to platinum treatment has been shown to improve survival but at the cost of significant ne...

    Authors: Yun Wang, Jørn Herrstedt, Hanne Havsteen, Rene DePoint Christensen, Mansoor Raza Mirza, Bente Lund, Johanna Maenpaa and Gunnar Kristensen
    Citation: BMC Cancer 2014 14:937
    Content type: Research article Published on:

  37. Breast cancer places a heavy burden on the Australian healthcare system, but information about the actual number of women living with breast cancer and their current or future health service needs is limited. ...

    Authors: Xue Qin Yu, Roberta De Angelis, Qingwei Luo, Clare Kahn, Nehmat Houssami and Dianne L O’Connell
    Citation: BMC Cancer 2014 14:936
    Content type: Research article Published on:

  38. Due to the lack of ERα, triple negative breast cancers (TNBCs) are not susceptible to endocrine therapy using antiestrogens. However, the majority of TNBCs express the membrane bound estrogen receptor GPR30. W...

    Authors: Rainer Girgert, Günter Emons and Carsten Gründker
    Citation: BMC Cancer 2014 14:935
    Content type: Research article Published on:

  39. Although radiotherapy is a key component of curative-intent treatment for locally advanced, unresectable non-small cell lung cancer (NSCLC), it can be associated with substantial pulmonary toxicity in some pat...

    Authors: Douglas A Hoover, Dante PI Capaldi, Khadija Sheikh, David A Palma, George B Rodrigues, A Rashid Dar, Edward Yu, Brian Dingle, Mark Landis, Walter Kocha, Michael Sanatani, Mark Vincent, Jawaid Younus, Sara Kuruvilla, Stewart Gaede, Grace Parraga…
    Citation: BMC Cancer 2014 14:934
    Content type: Study protocol Published on:

  40. Recently, with the access of low toxicity biological and targeted therapies, evidence of the existence of a long-term survival subpopulation of cancer patients is appearing. We have studied an unselected popul...

    Authors: Lizet Sanchez, Patricia Lorenzo-Luaces, Carmen Viada, Yaima Galan, Javier Ballesteros, Tania Crombet and Agustin Lage
    Citation: BMC Cancer 2014 14:933
    Content type: Research article Published on:

  41. Long non-coding RNAs have been shown to have critical regulatory roles in cancer biology. However, the contributions of lncRNAs to gastric cancer remain largely unknown.

    Authors: Yuehua Han, Jun Ye, Dang Wu, Pin Wu, Zhigang Chen, Jian Chen, Shunliang Gao and Jian Huang
    Citation: BMC Cancer 2014 14:932
    Content type: Research article Published on:

  42. It is unclear whether patients with few cerebral metastases benefit from whole-brain irradiation added to radiosurgery. Since primary tumors disseminating to the brain show different behavior, this question sh...

    Authors: Dirk Rades, Stefan Huttenlocher, Dagmar Hornung, Oliver Blanck and Steven E Schild
    Citation: BMC Cancer 2014 14:931
    Content type: Research article Published on:

  44. Despite the preclinical outcomes and biologic significance of the presence of the human epidermal growth factor receptor-2 (HER2) extracellular domain (ECD), there is little evidence supporting the measurement...

    Authors: Sae Byul Lee, Jong Won Lee, Jong Han Yu, Beom Seok Ko, Hee Jeong Kim, Byung Ho Son, Gyungyub Gong, Hee Jin Lee, Sung-Bae Kim, Kyung Hae Jung, Jin-Hee Ahn, Woochang Lee, Joohon Sung and Sei-Hyun Ahn
    Citation: BMC Cancer 2014 14:929
    Content type: Research article Published on:

  45. Amyloid-β precursor protein (APP) is a highly conserved single transmembrane protein that has been linked to Alzheimer disease. Recently, the increased expression of APP in multiple types of cancers has been r...

    Authors: Seunghwan Lim, Byoung Kwon Yoo, Hae-Suk Kim, Hannah L Gilmore, Yonghun Lee, Hyun-pil Lee, Seong-Jin Kim, John Letterio and Hyoung-gon Lee
    Citation: BMC Cancer 2014 14:928
    Content type: Research article Published on:

  46. Disparities by race and neighborhood socioeconomic status exist for many colorectal cancer (CRC) outcomes, including screening use and mortality. We used population-based data to determine if disparities also ...

    Authors: Sandi L Pruitt, Nicholas O Davidson, Samir Gupta, Yan Yan and Mario Schootman
    Citation: BMC Cancer 2014 14:927
    Content type: Research article Published on:

  47. Obesity is a risk factor for cancer incidence and survival, but data on patterns of weight change in cancer survivors are scarce and few stratify by pre-diagnosis weight status. In two population-based cohorts...

    Authors: Sarah E Jackson, Kate Williams, Andrew Steptoe and Jane Wardle
    Citation: BMC Cancer 2014 14:926
    Content type: Research article Published on:

  48. FUSE binding protein1 (FBP1) is a transactivator of transcription of human c-myc proto-oncogene and expressed mainly in undifferentiated cells. It is also present in differentiated normal cells albeit with very l...

    Authors: Updesh Dixit, Zhihe Liu, Ashutosh K Pandey, Ramesh Kothari and Virendra N Pandey
    Citation: BMC Cancer 2014 14:925
    Content type: Research article Published on:

  49. Trastuzumab was registered in 2000 for the treatment of metastatic breast cancer, both as monotherapy and combination therapy with paclitaxel. In this prospective, non-interventional observation study, the 10-...

    Authors: Christian Jackisch, Winfried Schoenegg, Dietmar Reichert, Manfred Welslau, Johannes Selbach, Hanns-Detlev Harich, Hans Tesch, Tim Wohlfarth, Heidi Eustermann and Axel Hinke
    Citation: BMC Cancer 2014 14:924
    Content type: Research article Published on:

  50. Glioblastoma (GBM) is the most common primary brain tumor and the most aggressive glial tumor. This tumor is highly heterogeneous, angiogenic, and insensitive to radio- and chemotherapy. Here we have investiga...

    Authors: Celina Garcia, Luiz Gustavo Dubois, Anna Lenice Xavier, Luiz Henrique Geraldo, Anna Carolina Carvalho da Fonseca, Ana Helena Correia, Fernanda Meirelles, Grasiella Ventura, Luciana Romão, Nathalie Henriques Silva Canedo, Jorge Marcondes de Souza, João Ricardo Lacerda de Menezes, Vivaldo Moura-Neto, Fernanda Tovar-Moll and Flavia Regina Souza Lima
    Citation: BMC Cancer 2014 14:923
    Content type: Technical advance Published on:

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