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  1. Glioblastoma (GBM) is the most common primary intracranial tumor in the central nervous system, and resistance to temozolomide is an important reason for the failure of GBM treatment. We screened out that Solu...

    Authors: Lan Jiang, Jianke Yang, Qiancheng Xu, Kun Lv and Yunpeng Cao
    Citation: BMC Cancer 2022 22:882
  2. Glutathione Peroxidase 4 (GPX4) is a key protein that inhibits ferroptosis. However, its biological regulation and mechanism in endometrial cancer (EC) have not been reported in detail.

    Authors: Sitian Wei, Zhicheng Yu, Rui Shi, Lanfen An, Qi Zhang, Qian Zhang, Tangansu Zhang, Jun Zhang and Hongbo Wang
    Citation: BMC Cancer 2022 22:881
  3. Distinguishing patients at a greater risk of recurrence is essential for treating locoregional advanced nasopharyngeal carcinoma (NPC). This study aimed to explore the potential of aldo–keto reductase 1C4 (AKR...

    Authors: Shan-Shan Guo, Yan-Zhou Chen, Li-Ting Liu, Rong-Ping Liu, Yu-Jing Liang, Dong-Xiang Wen, Jing Jin, Lin-Quan Tang, Hai-Qiang Mai and Qiu-Yan Chen
    Citation: BMC Cancer 2022 22:880
  4. Pancreatic cancer (PC) is a highly lethal and aggressive disease with its incidence and mortality quite discouraging. A robust prognostic signature and novel biomarkers are urgently needed for accurate stratif...

    Authors: Chengcheng Wang, Yuan Chen, Yin Xinpeng, Ruiyuan Xu, Jianlu Song, Rexiati Ruze, Qiang Xu and Yupei Zhao
    Citation: BMC Cancer 2022 22:879
  5. Pre-treatment risk and prognostic groups are the cornerstone for deciding management in non-metastatic prostate cancer. All however, were developed in the pre-MRI era. Here we compared categorisation of cancer...

    Authors: Artitaya Lophatananon, Matthew H. V. Byrne, Tristan Barrett, Anne Warren, Kenneth Muir, Ibifuro Dokubo, Fanos Georgiades, Mostafa Sheba, Lisa Bibby and Vincent J. Gnanapragasam
    Citation: BMC Cancer 2022 22:878
  6. Breast cancer incidence is increasing rapidly in Latin America, with a higher proportion of cases among young women than in developed countries. Studies have linked inflammation to breast cancer development, b...

    Authors: Emma Fontvieille, Mathilde His, Carine Biessy, Anne-Sophie Navionis, Gabriela Torres-Mejía, Angélica Ángeles-Llerenas, Isabel Alvarado-Cabrero, Gloria Inés Sánchez, Edgar Navarro, Yorlany Rodas Cortes, Carolina Porras, Ana Cecilia Rodriguez, Maria Luisa Garmendia, José Luis Soto, Leonor Moyano, Peggy L. Porter…
    Citation: BMC Cancer 2022 22:877
  7. Evidences have indicated that miR-26a-5p regulates the malignant properties of various tumor cells. However, the influences of miR-26a-5p on proliferation, apoptosis and invasion are still vague in the cervica...

    Authors: Ming Li, Yubo Xiao, Minqi Liu, Qian Ning, Ziye Xiang, Xiang Zheng, Shengsong Tang and Zhongcheng Mo
    Citation: BMC Cancer 2022 22:876
  8. We studied the prognosis and clinicopathological background of lung adenocarcinoma predominance among patients who underwent lobectomy using data from the Japanese Joint Committee of Lung Cancer Registry.

    Authors: Hiroyuki Ito, Hiroshi Date, Yasushi Shintani, Etsuo Miyaoka, Ryoichi Nakanishi, Mitsutaka Kadokura, Shunsuke Endo, Masayuki Chida, Ichiro Yoshino and Hidemi Suzuki
    Citation: BMC Cancer 2022 22:875
  9. Breast cancer, comprising of several sub-phenotypes, is a leading cause of female cancer-related mortality in the UK and accounts for 15% of all cancer cases. Chemoresistant sub phenotypes of breast cancer rem...

    Authors: Layla Alnoumas, Lisa van den Driest, Zoe Apczynski, Alison Lannigan, Caroline H. Johnson, Nicholas J. W. Rattray and Zahra Rattray
    Citation: BMC Cancer 2022 22:874
  10. Lycorine (Lyc) is a natural alkaloid derived from medicinal plants of the Amaryllidaceae family. Lyc has been reported to inhibit the recurrence and metastasis of different kinds of tumors. However, Lyc’s effe...

    Authors: Fei Lv, XiaoQi Li and Ying Wang
    Citation: BMC Cancer 2022 22:873
  11. The determination of HER2 expression status contributes significantly to HER2-targeted therapy in breast carcinoma. However, an economical, efficient, and non-invasive assessment of HER2 is lacking. We aimed t...

    Authors: Aqiao Xu, Xiufeng Chu, Shengjian Zhang, Jing Zheng, Dabao Shi, Shasha Lv, Feng Li and Xiaobo Weng
    Citation: BMC Cancer 2022 22:872
  12. EphrinA (EFNA) are Eph receptor ligands that regulate various disease processes. Nonetheless, the expression characteristics of EFNAs in pan-cancer, their relationship with tumor immune microenvironment, and p...

    Authors: Zonglin Jiao, Xiao Feng, Yuqing Cui, Lei Wang, Junqing Gan, Yanbin Zhao and Qingwei Meng
    Citation: BMC Cancer 2022 22:871
  13. Sodium selenite (SSE) has been reported to exert anti-tumor effects in several cancer cells. However, the underlying mechanisms in renal cancer are yet to be elucidated. The effects of SSE on the proliferation...

    Authors: Xiao Liu, Meng Jiang, Chenggang Pang, Jianning Wang and Lijuan Hu
    Citation: BMC Cancer 2022 22:870
  14. Aberrant fibroblast growth factor receptor (FGFR) signaling can substantially influence oncogenicity. Despite that FGFR gene abnormality is often detected by cancer genome profiling tests, there is no tumor-ag...

    Authors: Yohei Chiba, Kazuki Sudo, Yuki Kojima, Hitomi Okuma, Shinji Kohsaka, Ryunosuke Machida, Masahiko Ichimura, Kenta Anjo, Kazumi Kurishita, Natsuko Okita, Kenichi Nakamura, Ichiro Kinoshita, Masanobu Takahashi, Junichi Matsubara, Hitoshi Kusaba, Kan Yonemori…
    Citation: BMC Cancer 2022 22:869
  15. Preoperative neoadjuvant chemoradiation (nCRT) has been the standard treatment for locally advanced rectal cancer. Serum biomarkers to stratify patients with respect to prognosis and response to nCRT are neede...

    Authors: Hanyang Wang, Dengbo Ji, Huifang Tian, Zhaoya Gao, Can Song, Jinying Jia, Xinxin Cui, Lijun Zhong, Jing Shen and Jin Gu
    Citation: BMC Cancer 2022 22:868
  16. LncRNA N6-methylandenosine (m6A) modification has been shown to be associated with the constitution of the tumor microenvironment (TME) and tumorigenesis. It’s essential to understand the mechanisms of lncRNA ...

    Authors: Bo Chen, Zhan Yang, Zhichao Lang, Qiqi Tao, Rongrong Zhang, Yating Zhan, Xuantong Xu, Kai Zhu, Jianjian Zheng, Zhengping Yu and Suhui Yu
    Citation: BMC Cancer 2022 22:867
  17. Lung squamous cell carcinoma (LUSC) is prone to metastasis and likely to develop resistance to chemotherapeutic drugs. DNA repair has been reported to be involved in the progression and chemoresistance of LUSC...

    Authors: Xinshu Wang, Zhiyuan Huang, Lei Li, Guangxue Wang, Lin Dong, Qinchuan Li, Jian Yuan and Yunhui Li
    Citation: BMC Cancer 2022 22:866
  18. The role of adjuvant radiation in pancreatic adenocarcinoma (PDAC) remains unclear. We aimed to investigate the efficacy of gemcitabine combined with stereotactic body radiation therapy (SBRT) as adjuvant ther...

    Authors: Tao Ma, Xueli Bai, Qichun Wei, Yongjie Shui, Mengyi Lao, Wen Chen, Bingfeng Huang, Risheng Que, Shunliang Gao, Yun Zhang, Wei Chen, Ji Wang and Tingbo Liang
    Citation: BMC Cancer 2022 22:865
  19. IFN-γ has been traditionally recognized as an inflammatory cytokine that involves in inflammation and autoimmune diseases. Previously we have shown that sustained IFN-γ induced malignant transformation of bovi...

    Authors: Li Li, Fengyang Li, Xiuhong Hu, Zengshuai Wu, Wenbo Ren, Tingting Wang, Zhengchao Ji, Na Li, Jingmin Gu, Changjiang Sun, Xin Feng, Wenyu Han, Jing Huang and Liancheng Lei
    Citation: BMC Cancer 2022 22:864
  20. There is no clear consensus on the benefits of adjuvant chemotherapy for tumor-node-metastasis (TNM) stage T1 (T1N0M0) breast cancer (BC). Our study investigated the effects of adjuvant chemotherapy on T1N0M0 ...

    Authors: Kaiwen Shen, Longdi Yao, Jingyuan Zhu, Ximing Gu, Jie Wang, Wei Qian, Zhijian Zheng, Deyuan Fu and Song Wu
    Citation: BMC Cancer 2022 22:863
  21. Cervical cancer is a preventable disease, but it is a major public health problem despite having a good prognosis when diagnosed early. Although the Pap smear has led to huge drops in rates of cervical cancer ...

    Authors: Neila Pierote Gaspar Nascimento, Thais Borges Gally, Grasiely Faccin Borges, Luciene Cristina Gastalho Campos and Carla Martins Kaneto
    Citation: BMC Cancer 2022 22:862
  22. Tumor budding is associated with lymph node (LN) metastasis in submucosal colorectal cancer (CRC). However, the rate of LN metastasis associated with the number of tumor buds is unknown. Here, we determined th...

    Authors: Jeong-ki Kim, Ye-Young Rhee, Jeong Mo Bae, Jung Ho Kim, Seong-Joon Koh, Hyun Jung Lee, Jong Pil Im, Min Jung Kim, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park, Ji Won Park and Gyeong Hoon Kang
    Citation: BMC Cancer 2022 22:861
  23. The adjuvant treatment with Aromatase Inhibitor (AI) is considered standard of care for postmenopausal breast cancer (BC) women with hormone receptor-positive (HR +), however, it often causes adverse effects s...

    Authors: Isis Danyelle Dias Custódio, Fernanda Silva Mazzutti Nunes, Mariana Tavares Miranda Lima, Kamila Pires de Carvalho, Débora Santana Alves, Juliana Freitas Chiaretto, Paula Philbert Lajolo Canto, Carlos Eduardo Paiva and Yara Cristina de Paiva Maia
    Citation: BMC Cancer 2022 22:860
  24. The KMT2A gene, formerly named the MLL gene, is rearranged (KMT2Ar) in 70–75% of infants, 5–6% of children and 10–15% of adult patients with B cell acute lymphoblastic leukemia (B-ALL). The outcome after chemothe...

    Authors: Jinquan Wen, Min Zhou, Yali Shen, Yueting long, Yuxia Guo, Lin Song and Jianwen Xiao
    Citation: BMC Cancer 2022 22:859
  25. Inflammatory parameters and Epstein–Barr virus (EBV) DNA status have been confirmed to be associated with prognosis in nasopharyngeal carcinoma (NPC) patients. However, there are few in-depth studies on the pr...

    Authors: Xiaofei Yuan, Hua Yang, Fangfang Zeng, Shiyu Zhou, Shuting Wu, Yue Yuan, Linchong Cui, Huiru Feng, Danfan Lin, Zilu Chen, Xiong Liu, Jing Chen and Fan Wang
    Citation: BMC Cancer 2022 22:858
  26. Liver cirrhosis is a well-known risk factor for hepatocellular carcinoma (HCC). However, some HCC cases can also originate from non-cirrhotic livers. The aim of this study was to identify key circular RNAs (ci...

    Authors: Hongyu Li, Liangliang Xu, Pengsheng Yi, Lian Li, Tao Yan, Liang Xie and Zhijun Zhu
    Citation: BMC Cancer 2022 22:857
  27. Active surveillance (AS) is one of the treatment methods for patients with small renal masses (SRMs; < 4 cm), including renal cell carcinomas (RCCs). However, some small RCCs may exhibit aggressive neoplastic ...

    Authors: Masato Yanagi, Tomonari Kiriyama, Jun Akatsuka, Yuki Endo, Hayato Takeda, Akifumi Katsu, Yuichiro Honda, Kyota Suzuki, Yoshihiro Nishikawa, Shunsuke Ikuma, Hikaru Mikami, Yuka Toyama, Go Kimura and Yukihiro Kondo
    Citation: BMC Cancer 2022 22:856
  28. Persistent high-risk (hr) human papillomavirus (HPV) infection is a necessary cause of cervical cancer. Cervical cancer is a major public health problem in Sub-Saharan Africa including South Africa. This study...

    Authors: Teboho Amelia Tiiti, Selokela Gloria Selabe, Johannes Bogers and Ramokone Lisbeth Lebelo
    Citation: BMC Cancer 2022 22:854
  29. High-sensitivity C-reactive protein (hs-CRP) levels and metabolic syndrome (MetS) are known to be associated with an increased incidence of different cancers. We aimed to evaluate the effect of MetS combined w...

    Authors: Mengmeng Song, Tong Liu, Hai Liu, Qi Zhang, Qingsong Zhang, Yiming Wang, Xiangming Ma, Liying Cao and Hanping Shi
    Citation: BMC Cancer 2022 22:853
  30. Tumor acidosis, a common phenomenon in solid cancers such as breast cancer, is caused by the abnormal metabolism of cancer cells. The low pH affects cells surrounding the cancer, and tumor acidosis has been sh...

    Authors: Yong-Jin Kwon, Eun-Bi Seo, Ae Jin Jeong, Song-Hee Lee, Kum Hee Noh, Sangsik Lee, Chung-Hyun Cho, Chang-Han Lee, Hyun Mu Shin, Hang-Rae Kim, Hyeong-Gon Moon and Sang-Kyu Ye
    Citation: BMC Cancer 2022 22:852
  31. Trials investigating neoadjuvant treatment with immune checkpoint inhibitors (ICI) in patients with melanoma have shown high clinical and pathologic response rates. Treatment with talimogene laherparepvec (T-V...

    Authors: Maartje W. Rohaan, Emma H. A. Stahlie, Viola Franke, Lisanne P. Zijlker, Sofie Wilgenhof, Vincent van der Noort, Alexander C. J. van Akkooi and John B. A. G. Haanen
    Citation: BMC Cancer 2022 22:851
  32. The pandemic disrupted society and health services through lockdowns and resource reallocation to care for COVID-19 patients. Reductions in numbers of cancer patients having surgery, being diagnosed pathologic...

    Authors: Helen Mitchell, Ben S. Alford, Simon O’Hare, Eamon O’Callaghan, Colin Fox and Anna T. Gavin
    Citation: BMC Cancer 2022 22:850
  33. Breast cancer is an umbrella term referring to a group of biologically and molecularly heterogeneous diseases originating from the breast. Globally, incidences of breast cancer has been increasing dramatically...

    Authors: Ping-Hung Liu, James Cheng-Chung Wei, Yu-Hsun Wang and Ming-Hsin Yeh
    Citation: BMC Cancer 2022 22:849
  34. While cancer outcomes have improved over time, in Northern Ireland they continue to lag behind those of many other developed economies. The role of comorbid conditions has been suggested as a potential contrib...

    Authors: Ciaran O’Neill, David W. Donnelly, Mark Harbinson, Therese Kearney, Colin R. Fox, Gerard Walls and Anna Gavin
    Citation: BMC Cancer 2022 22:847
  35. Whether hypokalemia can affect the short-term outcomes of CRC patients after radical surgery remains unclear. The purpose of this study was to investigate the impact of preoperative hypokalemia on the short-te...

    Authors: Bin Zhang, Xiao-Yu Liu, Bing Kang, Chao Yuan, Zi-Wei Li, Zheng-Qiang Wei and Dong Peng
    Citation: BMC Cancer 2022 22:846
  36. Although immune-checkpoint inhibitors (ICI) are overall promissory for cancer treatment, they entail, in some cases, an undesired side-effect called hyperprogressive-cancer disease (HPD) associated with accele...

    Authors: Daniela R. Montagna, Alejandra Duarte, Paula Chiarella, Bárbara Rearte, Oscar D. Bustuoabad, Mónica Vermeulen and Raúl A. Ruggiero
    Citation: BMC Cancer 2022 22:845
  37. Glioblastoma (GBM) is one of the deadliest cancers. Treatment options are limited, and median patient survival is only several months. Translation of new therapies is hindered by a lack of GBM models that full...

    Authors: Julia A. Schulz, Louis T. Rodgers, Richard J. Kryscio, Anika M.S. Hartz and Björn Bauer
    Citation: BMC Cancer 2022 22:844
  38. Glioblastoma (GB) is the most common and most aggressive malignant brain tumor. In understanding its resistance to conventional treatments, iron metabolism and related pathways may represent a novel avenue. As...

    Authors: Charlotte Roy, Sylvie Avril, Claire Legendre, Bénédicte Lelièvre, Honorine Vellenriter, Sébastien Boni, Jérôme Cayon, Catherine Guillet, Yannick Guilloux, Michel Chérel, François Hindré and Emmanuel Garcion
    Citation: BMC Cancer 2022 22:843
  39. Acute, catastrophic bleeding in patients with head and neck cancer (HNC) is challenging and also a burden for their families and frontline physicians. This study analyzed the risk factors for rebleeding and lo...

    Authors: Chih-Kai Wang, Che-Fang Ho, Kuang-Yu Niu, Chia-Chien Wu, Yun-Chen Chang, Chien-Han Hsiao and Chieh-Ching Yen
    Citation: BMC Cancer 2022 22:841
  40. Inflammatory indices and tumor-infiltrating lymphocytes (TILs) have prognostic value in many cancer types. This study aimed to assess the prognostic value of inflammatory indices and evaluate their correlation...

    Authors: Hiroki Kanno, Toru Hisaka, Jun Akiba, Kazuaki Hashimoto, Fumihiko Fujita and Yoshito Akagi
    Citation: BMC Cancer 2022 22:839
  41. Most recent laboratory studies have suggested a promising role of vitamin D and its analogs as novel chemotherapeutic agents for cancer treatment. However, epidemiological evidence, especially regarding the ef...

    Authors: Minh Thien Nguyen, Nhi Ngoc Yen Huynh, Dai Duc Nguyen, Nguyen Ha Ta, Tai Van Nguyen, Huy Thanh Dang and Ngoan Tran Le
    Citation: BMC Cancer 2022 22:838
  42. Despite benefits of endocrine therapy (ET) for patients with hormone-receptor (HR)-positive breast cancer, many patients do not initiate or discontinue ET against recommendations.

    Authors: Beomyoung Cho, Maria Pérez, Donna B. Jeffe, Matthew W. Kreuter, Julie A. Margenthaler, Graham A. Colditz and Ying Liu
    Citation: BMC Cancer 2022 22:837
  43. A deep understanding of potential molecular biomarkers and therapeutic targets related to the progression of colorectal cancer (CRC) from early stages to metastasis remain mostly undone. Moreover, the regulati...

    Authors: Pouria Samadi, Meysam Soleimani, Fatemeh Nouri, Fatemeh Rahbarizadeh, Rezvan Najafi and Akram Jalali
    Citation: BMC Cancer 2022 22:835
  44. Enhanced recovery after surgery programs have reduced complications and shortened hospital stays after lung resection. This study aimed to determine whether video-assisted thoracoscopic surgery performed as a ...

    Authors: Guofei Zhang, Junqiang Fan, Zipu Yu, Ying Chai, Sai Zhang, Ming Wu and Gang Shen
    Citation: BMC Cancer 2022 22:832
  45. To evaluate the diagnostic value of adding human epididymis protein 4 (HE4), cancer antigen 125 (CA125) and risk of malignancy algorithm (ROMA) to ultrasound for detecting ovarian cancer in patients with a pel...

    Authors: Elena Ioana Braicu, Catherine Linn Krause, Uwe Torsten, Herbert Mecke, Rolf Richter, Lars Hellmeyer, Malgorzata Lanowska, Bodo Müller, Elisa Koch, Janine Boenneß-Zaloum, Kerstin Ames, Radoslav Chekerov, Kati Hasenbein, Mathias Zimmermann, Mandy Mangler, Frank Chen…
    Citation: BMC Cancer 2022 22:831
  46. Hepatocellular carcinoma (HCC) is one of the most lethal cancers, with a poor prognosis. Prognostic biomarkers for HCC patients are urgently needed. We aimed to establish a nomogram prediction system that comb...

    Authors: Renguo Guan, Jingwen Zou, Jie Mei, Min Deng and Rongping Guo
    Citation: BMC Cancer 2022 22:830

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