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  1. The optimal duration of anti-PD-1 for cancer therapy has not been tested, especially when using combination therapy. Epidermal growth factor receptor (EGFR) pathway blocker was the top compound that enhanced T...

    Authors: Hsiang-Fong Kao, Huai-Cheng Huang, Bin-Chi Liao and Ruey-Long Hong
    Citation: BMC Cancer 2022 22:1228
  2. HPV has been detected in approximately 50% of invasive penile cancers but with a large span between 24 and 89%, most likely due to different types of tumors and various methods for HPV analysis. Most studies o...

    Authors: Sinja Kristiansen, Carina Bjartling, Christian Torbrand, Diane Grelaud, Martin Lindström, Åke Svensson and Ola Forslund
    Citation: BMC Cancer 2022 22:1227
  3. Cervical cancer is one of the most common cancer types among women in developing countries. Women’s behavior in the early detection of the disease is influenced by sociocultural factors. Thus, the present stud...

    Authors: Niloofar Seyrafi, Atefeh Homayuni, Zahra Hosseini, Teamur Aghamolaei, Amin Ghanbarnejad and Ali Mouseli
    Citation: BMC Cancer 2022 22:1226
  4. Authors: C. Martínez-Laperche, L. Sanz-Villanueva, F. J. Díaz Crespo, P. Muñiz, R. Martín Rojas, D. Carbonell, M. Chicano, J. Suárez-González, J. Menárguez, M. Kwon, J. L. Diez Martín, I. Buño and M. Bastos Oreiro
    Citation: BMC Cancer 2022 22:1224

    The original article was published in BMC Cancer 2022 22:982

  5. Paclitaxel plus S-1(PTXS) has shown definite efficacy for advanced gastric cancer. However, the efficacy and safety of this regimen in neoadjuvant setting for locally advanced gastric cancer (LAGC) are unclear...

    Authors: Chenghai Zhang, Binghong Wu, Hong Yang, Zhendan Yao, Nan Zhang, Fei Tan, Maoxing Liu, Kai Xu, Lei Chen, Jiadi Xing, Ming Cui and Xiangqian Su
    Citation: BMC Cancer 2022 22:1223
  6. Clinicians increasingly perform laparoscopic surgery for intrahepatic cholangiocarcinoma (ICC). However, this surgery can be difficult in patients with advanced-stage ICC because of the complicated procedures ...

    Authors: Cheng-Yu Liao, Dan-Feng Wang, Bin-Hua Jiang, Long Huang, Tian-Sheng Lin, Fu-Nan Qiu, Song-Qiang Zhou, Yao-Dong Wang, Xiao-Chun Zheng, Yi-Feng Tian and Shi Chen
    Citation: BMC Cancer 2022 22:1222
  7. Molecular subgrouping of medulloblastoma has become important due to its impact on risk group stratification. Immunohistochemistry (IHC) has been widely used but it has innate limitations. The NanoString assay...

    Authors: Joo Whan Kim, Sung-Hye Park, Seung Ah Choi, Seung-Ki Kim, Eun Jung Koh, Jae-Kyung Won, Sun Mo Nam and Ji Hoon Phi
    Citation: BMC Cancer 2022 22:1221
  8. Owing to non-responsiveness of a high number of patients to the common melanoma therapies, seeking novel approaches seem as an unmet requirement. Chimeric antigen receptor (CAR) T cells were initially employed...

    Authors: Maryam Bahmanyar, Mohammad Kazem Vakil, Ghaidaa Raheem Lateef Al-Awsi, Seyed Amin Kouhpayeh, Yaser Mansoori, Behnam Mansoori, Ali Moravej, Abdulbaset Mazarzaei and Abdolmajid Ghasemian
    Citation: BMC Cancer 2022 22:1220
  9. Previous studies have observed an increased incidence of Cetuximab-induced hypersensitivity infusion reactions (CI-IRs) in the southeastern states of the USA. Tick’s bites were suspected of generating cross-re...

    Authors: M Dupont, Claire Carlier, C Gower-Rousseau, P Barbier-Lider, D Botsen, M Brasseur, A Burgevin, C Chourbagi, R D’Almeida, V Hautefeuille, M Hentzien, A Lambert, M Lamuraglia, S Lavau-Denes, A Lopez, D Parent…
    Citation: BMC Cancer 2022 22:1219
  10. Combination chemoimmunotherapy (CIT) consisting of anti-CD20 has improved the progression-free survival (PFS) and overall survival (OS) of patients with chronic lymphocytic leukaemia (CLL). We performed a comp...

    Authors: Zekhethelo A. Mkhwanazi, Tawanda M. Nyambuya, Snenhlanhla A. Mfusi and Bongani B. Nkambule
    Citation: BMC Cancer 2022 22:1218
  11. Recent studies have shown a lower likelihood of locoregional recurrences in patients with a low 21-gene recurrence score (RS). In this single-institution study, we investigated whether there are any associatio...

    Authors: Cihan Uras, Neslihan Cabioglu, Fatma Tokat, Ozlem Er, Halil Kara, Taner Korkmaz, Nuran Bese and Umit Ince
    Citation: BMC Cancer 2022 22:1217
  12. Ovarian cancer is one of the most lethal gynecologic malignancies with a dismal prognosis that poses a serious threat to human health, highlighting the need for more knowledge about what is required for identi...

    Authors: Sai Li, Sifu Yang and Yupeng Hong
    Citation: BMC Cancer 2022 22:1216
  13. Mesothelin (MSLN) is a cell-surface glycoprotein found in various solid tumours. Cancer therapies targeting MSLN have been developed in recent years; however, the available information on MSLN expression in ce...

    Authors: Shigemasa Takamizawa, Shu Yazaki, Yuki Kojima, Hiroshi Yoshida, Rui Kitadai, Tadaaki Nishikawa, Tatsunori Shimoi, Kazuki Sudo, Hitomi Sumiyoshi Okuma, Maki Tanioka, Emi Noguchi, Masaya Uno, Mitsuya Ishikawa, Tomoyasu Kato, Yasuhiro Fujiwara and Kan Yonemori
    Citation: BMC Cancer 2022 22:1215
  14. The association between the combination of platelet count and neutrophil–lymphocyte ratio (COP-NLR) at the time of adverse events during sunitinib treatment and prognosis is unclear, and prognostic models comb...

    Authors: Miki Takenaka Sato, Ayuki Ida, Yuki Kanda, Kaori Takano, Masayuki Ohbayashi, Noriko Kohyama, Jun Morita, Kohzo Fuji, Haruaki Sasaki, Yoshio Ogawa and Mari Kogo
    Citation: BMC Cancer 2022 22:1214
  15. Urothelial carcinoma (UC) is the ninth most commonly diagnosed cancer worldwide, with a 3.8/1 male to female ratio. Platinum-based chemotherapy is the first line standard of care for fit patients with advanced...

    Authors: Elodie Coquan, Bénédicte Clarisse, Justine Lequesne, Pierre-Emmanuel Brachet, Zoé Nevière, Emeline Meriaux, Isabelle Bonnet, Marie Castera, Nicolas Goardon, Jeremy Boutrois, Romain Travers, Florence Joly, Jean-Michel Grellard and Antoine Thiery-Vuillemin
    Citation: BMC Cancer 2022 22:1213
  16. Nutritional support, including nutritional counseling and oral nutritional supplements (ONS), has been recommended as a first-line strategy in patients with non-small cell lung cancer (NSCLC). Evidence on the ...

    Authors: Riccardo Caccialanza, Emanuele Cereda, Francesco Agustoni, Catherine Klersy, Amanda Casirati, Elisabetta Montagna, Simona Carnio, Silvia Novello, Michele Milella, Sara Pilotto, Ilaria Trestini, Lucio Buffoni, Alessandra Ferrari and Paolo Pedrazzoli
    Citation: BMC Cancer 2022 22:1212
  17. Vast amounts of rapidly accumulating biological data related to cancer and a remarkable progress in the field of artificial intelligence (AI) have paved the way for precision oncology. Our recent contribution ...

    Authors: Manali Singha, Limeng Pu, Brent A. Stanfield, Ifeanyi K. Uche, Paul J. F. Rider, Konstantin G. Kousoulas, J. Ramanujam and Michal Brylinski
    Citation: BMC Cancer 2022 22:1211
  18. We aimed to elucidate the temporal and spatial characteristics of tumor evolution in an oral squamous cell carcinoma (OSCC) mouse model with higher burden of lymphatic metastasis through high-throughput sequen...

    Authors: Yong Cao, Hao Dong, Guangyu Li, Huiping Wei, Cheng Xie, Yangjuan Tuo, Nian Chen and Dahai Yu
    Citation: BMC Cancer 2022 22:1209
  19. Exosomes are a new way of the communication between the tumor cell and macrophage in the micro-environment. The macrophage can be induced to different phenotypes according to the different tumors. In the prese...

    Authors: Jingting Wang, Nan Wang, Zeyu Zheng, Yanlu Che, Masanobu Suzuki, Satoshi Kano, Jianguang Lu, Peng Wang, Yanan Sun and Akihiro Homma
    Citation: BMC Cancer 2022 22:1208
  20. In recent years, benchmarking and assessment methods to improve the quality of care have become increasingly important. Such approaches allow for a uniform assessment, comparisons between centers or over time,...

    Authors: Marcin Ziętek, Jędrzej Wierzbicki, Edyta Pawlak, Adam Maciejczyk and Rafał Matkowski
    Citation: BMC Cancer 2022 22:1207
  21. Previous studies confirmed that ground-glass nodules (GGNs) with certain CT manifestations had a higher probability of malignancy. However, differentiating patchy ground-glass opacities (GGOs) and GGNs has not...

    Authors: Zhang-rui Liang, Min Ye, Fa-jin Lv, Bin-jie Fu, Rui-yu Lin, Wang-jia Li and Zhi-gang Chu
    Citation: BMC Cancer 2022 22:1206
  22. It would be very helpful to stratify patients and direct patient selection if risk factors for quality of life were identified in a particular population. Nonetheless, it is still challenging to forecast the h...

    Authors: Yue Li, Ze Long, Xiuju Wang, Mingxing Lei, Chunzi Liu, Xiaolin Shi and Yaosheng Liu
    Citation: BMC Cancer 2022 22:1205
  23. Clear cell renal cell carcinoma (ccRCC) is a common malignant tumor of the urinary system characterized by poor prognosis and difficult treatment. It has been reported that iron metabolism dysregulation is a c...

    Authors: Jiyue Wu, Qing Bi, Xiang Zheng, Huawei Cao, Changzhen Hao, Zejia Sun and Wei Wang
    Citation: BMC Cancer 2022 22:1204
  24. The long-term oncologic outcomes after laparoscopic and open procedures for patients with intermediate‑ and high‑risk endometrial cancer (EC) remain unclear. Accordingly, laparoscopy cannot still be recommende...

    Authors: Xing Zhou, Sitian Wei, Qingchun Shao, Jun Zhang, Rong Zhao, Rui Shi, Wei Zhang, Kejun Dong, Wan Shu and Hongbo Wang
    Citation: BMC Cancer 2022 22:1203
  25. Weight gain is commonly observed during and after breast cancer treatment and is associated with poorer survival outcomes, particularly in women with oestrogen receptor-positive (ER +) disease. The aim of this...

    Authors: J. M. Saxton, K. Pickering, S. Wane, H. Humphreys, H. Crank, A. S. Anderson, H. Cain, J. Cohen, R. J. Copeland, J. Gray, J. Hargreaves, R. J. Q. McNally and C. Wilson
    Citation: BMC Cancer 2022 22:1202
  26. Triple-negative breast cancer (TNBC) is a heterogenous subtype involving different patterns of behavior and clinical course, demanding a complex, individualized sequence of treatment. The knowledge and attitud...

    Authors: Ruffo Freitas-Junior, Vilmar Marques de Oliveira, Antonio Luiz Frasson, Francisco Pimentel Cavalcante, Fabio Postiglione Mansani, André Mattar, Felipe Pereira Zerwes, Adriana Magalhães de Oliveira Freitas, Alessandra Borba Anton de Souza, Andrea P. Damin, Annamaria Massahud Rodrigues dos Santos, Carlos Alberto Ruiz, Clécio Ênio Murta de Lucena, Eduardo Camargo Millen, Fábio Bagnoli, Felipe Andrade…
    Citation: BMC Cancer 2022 22:1201
  27. In our previous study, N end of the Circumsporozoite protein (CSP I-plus) modified recombinant human Endostatin (rEndostatin, endostar) (rES-CSP) was constructed, which had antiangiogenic capability and bound ...

    Authors: Xueqin Chen, Yan Wang, Hancong Liu, Jingjing Zhang, Jie Wang, Xiaobao Jin and Yan Ma
    Citation: BMC Cancer 2022 22:1200
  28. Lung cancer is the third most frequent tumor and the main cause of death by tumor in Spain. Although the incidence and mortality are still significantly higher in men than in women, the disparity between the s...

    Authors: Abraham Galindo-Utrero, Jesús María San-Román-Montero, Ruth Gil-Prieto and Ángel Gil-de-Miguel
    Citation: BMC Cancer 2022 22:1199
  29. The associations with cancer and cardiovascular diseases (CVD) had inconsistent results. The study aimed to investigate the risk of cardiovascular diseases (CVD) between populations with and without cancer.

    Authors: Tzu-Lin Yeh, Min-Shu Hsu, Hsin-Yin Hsu, Ming-Chieh Tsai, Jing-Rong Jhuang, Chun-Ju Chiang, Wen-Chung Lee and Kuo-Liong Chien
    Citation: BMC Cancer 2022 22:1198
  30. The prognostic value of pretreatment and preoperative fibrinogen plasma levels and the modified Glasgow prognostic score (mGPS) in stage III/N2 non-small cell lung cancer (NSCLC) patients who receive neoadjuva...

    Authors: Katharina Sinn, Berta Mosleh, Michael Grusch, Walter Klepetko, Konrad Hoetzenecker, Thomas Klikovits, Daniela Gompelmann and Mir Alireza Hoda
    Citation: BMC Cancer 2022 22:1197
  31. While an important surgical landmark of the dentate line has been established for locally advanced lower rectal cancer (LALRC), the prognostic significance of dentate line invasion (DLI) has not been well defi...

    Authors: Maxiaowei Song, Hongzhi Wang, Lin Wang, Shuai Li, Yangzi Zhang, Jianhao Geng, Xianggao Zhu, Yongheng Li, Yong Cai and Weihu Wang
    Citation: BMC Cancer 2022 22:1196
  32. Early detection of bladder cancer (BCa) offers patients a favorable outcome and avoids the need for cystectomy. Development of an accurate and sensitive noninvasive BCa diagnostic test is imperative. DNA methy...

    Authors: Tae Jeong Oh, Eunkyung Lim, Bo-Ram Bang, Justin Junguek Lee, Yong Gil Na, Ju Hyun Shin, Jae Sung Lim, Ki Hak Song and Sungwhan An
    Citation: BMC Cancer 2022 22:1195
  33. The relative contributions of genetic and environmental factors versus unavoidable stochastic risk factors to the variation in cancer risk among tissues have become a widely-discussed topic. Some claim that th...

    Authors: Xinhui Liu, Jifeng Yang, Hongkai Li, Qing Wang, Yuanyuan Yu, Xiaoru Sun, Shucheng Si, Lei Hou, Lu Liu, Fan Yang, Ran Yan, Yifan Yu, Zhentao Fu, Zilong Lu, Dejin Li, Hao Xue…
    Citation: BMC Cancer 2022 22:1194
  34. The incidence of primary liver tumors, hepatocellular carcinoma (HCC), intrahepatic cholangiocellular carcinoma (ICC), and combined HCC/ICC (cHCC/CC) is increasing. For ICC, targeted therapy exists only for a ...

    Authors: Ihtzaz Ahmed Malik, Mansi Rajput, Rieke Werner, Dorothea Fey, Niloofar Salehzadeh, Christine A. F. von Arnim and Jörg Wilting
    Citation: BMC Cancer 2022 22:1193
  35. The real-world experience of Swiss chronic myeloid leukemia (CML) patients treated with tyrosine kinase inhibitors (TKIs) is largely unknown, in particular with regard to achievement of response per European L...

    Authors: Nathan Cantoni, Roberto Sommavilla, Patrick Seitz, Elisabeth Kulenkampff, Stefan Kahn, Jean-François Lambert, Adrian Schmidt, Reinhard Zenhaeusern and Stefan Balabanov
    Citation: BMC Cancer 2022 22:1192
  36. Synchronous multiple primary esophageal squamous cell carcinoma (S-MPESCC) refers to more than one primary esophageal carcinoma detected in a solitary patient at the time of initial presentation. The purpose o...

    Authors: Yueyang Yang, Peng Tang, Mingquan Ma, Hongdian Zhang, Haitong Wang, Kai Zhu, Wanyi Xiao, Lei Gong and Zhentao Yu
    Citation: BMC Cancer 2022 22:1191
  37. Umbilical cord blood transplantation (UCBT) from unrelated donors is one of the successful treatments for acute leukemia in childhood. The most frequent side effect of UCBT is peri-engraftment syndrome (PES), ...

    Authors: Xin-Yu Li, Li-Ping Zhan, Dian-Dian Liu, Xia-Wei Han, Han Chen, Zheng-Zhou Wu, Yin Wang, Li-Ping Que, Xiao-Jun Wu, Su Liu, Kai-Mei Wang, Shao-Liang Huang, Jian-Pei Fang, Ke Huang and Hong-Gui Xu
    Citation: BMC Cancer 2022 22:1190
  38. Weight gain is commonly observed during and after breast cancer treatment and is associated with poorer survival outcomes, notably in women with oestrogen-receptor positive disease. The aim of this qualitative...

    Authors: Saxton JM, Pickering K, Wane S, Crank H, Anderson AS, Cain H, Cohen J, Copeland RJ, Gray J, Hargreaves J, McNally RJQ and Wilson C
    Citation: BMC Cancer 2022 22:1189
  39. The aim of this study is to explore the expression and clinical relevance of CAF-associated markers, EZH2 and FOXM1 in gastric samples.

    Authors: Hui Sun, Xin Wang, Xiaoyan Zhang, Xu Wang, Cong Tan, Weiwei Weng, Meng Zhang, Shujuan Ni, Lei Wang, Dan Huang, Midie Xu and Weiqi Sheng
    Citation: BMC Cancer 2022 22:1188
  40. Obesity plays an important role in the development and progression of breast cancer via various oncogenic pathways. However, the biological mechanisms underlying this relationship are not fully understood. Mor...

    Authors: Dorothy Meyer, Belén Pastor-Villaescusa, Sophie Michel, Hans Hauner and Dagmar Hauner
    Citation: BMC Cancer 2022 22:1187
  41. An increasing number of studies have demonstrated that CX3CL1 is involved in the development of tumors and may thus be considered a new potential therapeutic target for them. However, the function of CX3CL1 in...

    Authors: Qiming Gong, Zhiting Guo, Wenjuan Sun, Xiuri Du, Yan Jiang and Fahui Liu
    Citation: BMC Cancer 2022 22:1184
  42. The C-reactive protein to albumin ratio (CAR) is associated with poor prognosis in various cancers. However, its value in thymic epithelial tumors remains to be elucidated, we aimed to evaluate the prognostic ...

    Authors: Yang-Yu Huang, Xuan Liu, Shen-Hua Liang, Yu Hu and Guo-Wei Ma
    Citation: BMC Cancer 2022 22:1183
  43. Gut microbiome has been linked to a regulatory role in cancer progression. However, whether broad-spectrum antibiotics (ATB) associated gut microbiome dysbiosis contributes to an impaired T cell immune functio...

    Authors: Ke Xu, Jixu Cai, Jun Xing, Xu Li, Beishou Wu, Zhuxian Zhu and Ziqiang Zhang
    Citation: BMC Cancer 2022 22:1182
  44. Repair pathway genes play an important role in the development of lung cancer. The study aimed to assess the correlation between single nucleotide polymorphisms (SNPs) in DNA repair gene (GTF2H1 and RAD54L2) and ...

    Authors: Tingting Geng, Miao Li, Rong Chen, Shuangyu Yang, Guoquan Jin, Tinabo Jin and Fulin Chen
    Citation: BMC Cancer 2022 22:1181
  45. Postoperative radiotherapy (PORT) could be useful for pN1 breast cancer patients who have undergone breast-conserving surgery (BCS) or mastectomy. However, the value of regional nodal irradiation (RNI) for BCS...

    Authors: Tae Hoon Lee, Ji Hyun Chang, Bum-Sup Jang, Jae Sik Kim, Tae Hyun Kim, Won Park, Yong Bae Kim, Su Ssan Kim, Wonshik Han, Han-Byoel Lee and Kyung Hwan Shin
    Citation: BMC Cancer 2022 22:1179

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