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  1. Content type: Research article

    A unified analysis of DNA sequences from hundreds of tumors concluded that the driver mutations primarily occur in the earliest stages of cancer formation, with relatively few driver mutation events detected i...

    Authors: Karen Gomez, Sayaka Miura, Louise A. Huuki, Brianna S. Spell, Jeffrey P. Townsend and Sudhir Kumar

    Citation: BMC Cancer 2018 18:85

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  2. Content type: Research article

    There is ongoing debate about the harms and benefits of a national prostate cancer screening programme. Several model-based cost-effectiveness analyses have been developed to determine whether the benefits of ...

    Authors: Sabina Sanghera, Joanna Coast, Richard M. Martin, Jenny L. Donovan and Syed Mohiuddin

    Citation: BMC Cancer 2018 18:84

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  3. Content type: Technical advance

    Metastases play a role in about 90% of cancer deaths. Markers of epithelial-mesenchymal transition (EMT) measured in primary tumor cancer cells might provide diagnostic information about the likelihood that ca...

    Authors: Evan L. Busch, Prabhani Kuruppumullage Don, Haitao Chu, David B. Richardson, Temitope O. Keku, David A. Eberhard, Christy L. Avery and Robert S. Sandler

    Citation: BMC Cancer 2018 18:82

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  4. Content type: Research article

    Side-effects have been considered as the limitation of the chemotherapy agents’ administration and life quality in patients with ovarian cancers. In order to explore the influence of the chemotherapy agents co...

    Authors: Yanxiu Guo, Haoxia Zeng, Xiaohong Chang, Chaohua Wang and Heng Cui

    Citation: BMC Cancer 2018 18:81

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  5. Content type: Research article

    We evaluated the incidence and spectrum of pathogenic and likely pathogenic variants of cancer susceptibility genes in BRCA1/2 mutation-negative Korean patients with a high risk for hereditary breast cancer using...

    Authors: Ji Soo Park, Seung-Tae Lee, Eun Ji Nam, Jung Woo Han, Jung-Yun Lee, Jieun Kim, Tae Il Kim and Hyung Seok Park

    Citation: BMC Cancer 2018 18:83

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  6. Content type: Correction

    After publication of the original article [1] the authors found that the article contained an incorrect version of Fig. 4. This does not affect the results and conclusions of the article.

    Authors: Fatemeh Kaveh, Lars O. Baumbusch, Daniel Nebdal, Anne-Lise Børresen-Dale, Ole Christian Lingjærde, Hege Edvardsen, Vessela N. Kristensen and Hiroko K. Solvang

    Citation: BMC Cancer 2018 18:80

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    The original article was published in BMC Cancer 2016 16:913

  7. Content type: Research article

    Colorectal cancer (CRC) is a leading cause of cancer-associated deaths with liver metastases developing in 25–30% of those affected. Previous data suggest a survival difference between right- and left-sided li...

    Authors: Jennie Engstrand, Henrik Nilsson, Cecilia Strömberg, Eduard Jonas and Jacob Freedman

    Citation: BMC Cancer 2018 18:78

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  8. Content type: Research article

    Vaccination of mice with tumors treated with Doxorubicin promotes a T cell immunity that relies on dendritic cell (DC) activation and is responsible for tumor control in vaccinated animals. Despite Doxorubicin...

    Authors: David A. Bernal-Estévez, Oscar García, Ramiro Sánchez and Carlos A. Parra-López

    Citation: BMC Cancer 2018 18:77

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  9. Content type: Research article

    The objective of this study is to investigate the role and experience of early stage non-small cell lung cancer (NSCLC) patient in decision making process concerning treatment selection in the current clinical...

    Authors: S. Mokhles, J. J. M. E. Nuyttens, M. de Mol, J. G. J. V. Aerts, A. P. W. M. Maat, Ö. Birim, A. J. J. C. Bogers and J. J. M. Takkenberg

    Citation: BMC Cancer 2018 18:79

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  10. Content type: Research article

    Obesity has been reported as an adverse prognostic factor in breast cancer, but inconsistently, and under-treatment with chemotherapy may occur. We provide the first assessment of obesity and breast cancer out...

    Authors: J. Mark Elwood, Sandar Tin Tin, Marion Kuper-Hommel, Ross Lawrenson and Ian Campbell

    Citation: BMC Cancer 2018 18:76

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  11. Content type: Research article

    To determine the effect of Yttrium-90 (Y90) radioembolization on health-related quality of life (HRQOL) and its effect on overall survival advanced, unresectable infiltrative hepatocellular carcinoma (HCC) pat...

    Authors: Minzhi Xing, Nima Kokabi, Juan C. Camacho and Hyun S. Kim

    Citation: BMC Cancer 2018 18:75

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  12. Content type: Research article

    Greater lymph node retrieval in gastric cancer improves staging accuracy and may improve survival from increased clearance of nodal micrometastasis. This retrospective cohort study investigated if more lymph n...

    Authors: Shiela S. Macalindong, Kwang Hee Kim, Byung-Ho Nam, Keun Won Ryu, Norihito Kubo, Ja Yeon Kim, Bang Wool Eom, Hong Man Yoon, Myeong-Cherl Kook, Il Ju Choi and Young Woo Kim

    Citation: BMC Cancer 2018 18:73

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  13. Content type: Research article

    Emerging evidence suggests molecular and phenotypic association between treatment resistance and epithelial–mesenchymal transition (EMT) in cancer. Compared with the well-defined molecular events of miR-200a i...

    Authors: San-Jian Yu, Liu Yang, Qi Hong, Xia-Ying Kuang, Gen-Hong Di and Zhi-Ming Shao

    Citation: BMC Cancer 2018 18:74

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  14. Content type: Research article

    Physical activity is consistently associated with a reduced risk of colorectal cancer in epidemiologic studies. This association among higher risk subgroups, such as those with a first-degree family history of...

    Authors: Eileen Shaw, Megan S. Farris, Chelsea R. Stone, Jeroen W. G. Derksen, Rhys Johnson, Robert J. Hilsden, Christine M. Friedenreich and Darren R. Brenner

    Citation: BMC Cancer 2018 18:71

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  15. Content type: Research article

    Biliary tract cancer (BTC) is a dismal disease, even after curative intent surgery. We conducted this prospective, non-randomized phase II study to evaluate the feasibility and efficacy of cisplatin and gemcit...

    Authors: Alexander R. Siebenhüner, Heike Seifert, Helga Bachmann, Burkhardt Seifert, Thomas Winder, Jonas Feilchenfeldt, Stefan Breitenstein, Pierre-Alain Clavien, Roger Stupp, Alexander Knuth, Bernhard Pestalozzi and Panagiotis Samaras

    Citation: BMC Cancer 2018 18:72

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  16. Content type: Correction

    After publication of the original article [1] the authors found that the figure contained an incorrect version of Fig. 3a. This does not affect the results and conclusions of the article.

    Authors: Xiao Wang, Jian Chen, Jingtao Wang, Fudong Yu, Senlin Zhao, Yu Zhang, Huamei Tang and Zhihai Peng

    Citation: BMC Cancer 2018 18:70

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    The original article was published in BMC Cancer 2016 16:383

  17. Content type: Research article

    RHEB is a unique member of the RAS superfamily of small GTPases expressed in all tissues and conserved from yeast to humans. Early studies on RHEB indicated a possible RHEB-RAF interaction, but this has not be...

    Authors: Jeffrey J. Heard, Ivy Phung, Mark I. Potes and Fuyuhiko Tamanoi

    Citation: BMC Cancer 2018 18:69

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  18. Content type: Study protocol

    Prostate cancer is the most commonly diagnosed cancer in north-American men. Few dietary or lifestyle interventions have been tested to prevent prostate cancer progression. Omega-3 fatty acid supplementation r...

    Authors: Marie-Hélène Guertin, Karine Robitaille, Jean-François Pelletier, Thierry Duchesne, Pierre Julien, Josée Savard, Isabelle Bairati and Vincent Fradet

    Citation: BMC Cancer 2018 18:64

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  19. Content type: Research article

    To assess the factorial structure, internal consistency, construct validity and reproducibility of the Quality of Working Life Questionnaire for Cancer Survivors (QWLQ-CS).

    Authors: Merel de Jong, Sietske J. Tamminga, Robert J. J. van Es, Monique H. W. Frings-Dresen and Angela G. E. M. de Boer

    Citation: BMC Cancer 2018 18:66

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  20. Content type: Research article

    Small GTP binding protein Rac1 is a component of NADPH oxidases and is essential for superoxide-induced cell death. Rac1 is activated by guanine nucleotide exchange factors (GEFs), and this activation can be b...

    Authors: Nan Wu, Dong Ren, Su Li, Wenli Ma, Shaoyan Hu, Yan Jin and Sheng Xiao

    Citation: BMC Cancer 2018 18:67

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  21. Content type: Study protocol

    Chemotherapy-induced peripheral neuropathy (CIPN) is a common and clinically relevant side effect of chemotherapy. Approximately 50% of all leukemia, lymphoma, colorectal- and breast cancer patients are affected.

    Authors: Fiona Streckmann, Maryam Balke, Helmar C. Lehmann, Vanessa Rustler, Christina Koliamitra, Thomas Elter, Michael Hallek, Michael Leitzmann, Tilman Steinmetz, Petra Heinen, Freerk T. Baumann and Wilhelm Bloch

    Citation: BMC Cancer 2018 18:62

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  22. Content type: Research article

    The circadian clock is the basis for biological time keeping in eukaryotic organisms. The clock mechanism relies on biochemical signaling pathways to detect environmental stimuli and to regulate the expression...

    Authors: Charles S. Goldsmith, Sam Moon Kim, Nirmala Karunarathna, Nichole Neuendorff, L. Gerard Toussaint, David J. Earnest and Deborah Bell-Pedersen

    Citation: BMC Cancer 2018 18:43

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  23. Content type: Research article

    The prognostic variability of thyroid carcinomas has led to the search for accurate biomarkers at the molecular level. Follicular thyroid carcinoma (FTC) is a typical example of differentiated thyroid carcinom...

    Authors: Ricardo Celestino, Torfinn Nome, Ana Pestana, Andreas M. Hoff, A. Pedro Gonçalves, Luísa Pereira, Bruno Cavadas, Catarina Eloy, Trine Bjøro, Manuel Sobrinho-Simões, Rolf I. Skotheim and Paula Soares

    Citation: BMC Cancer 2018 18:68

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  24. Content type: Study protocol

    Staging laparoscopy(SL) is a recommended technique for the staging of Gastric Cancer(GC) and provides the indication for a radical surgery. Considering the medical practice in China, the standardized and regul...

    Authors: Ziyu Li, Zhemin Li, Lianhai Zhang, Qian Liu, Zhenjun Wang, Zhongtao Zhang, Gang Xiao, Wei Fu, Xin Wang, Yingjiang Ye, Jianchun Yu, Fei Li, Lin Chen, Shibin Wang and Jiafu Ji

    Citation: BMC Cancer 2018 18:63

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  25. Content type: Research article

    Metformin is associated with a reduced risk of some cancers but its effect on prostate cancer is unclear. Some studies suggest only Asians derive this benefit. Therefore, we undertook a systematic review with ...

    Authors: Christopher B. Chen, Maxim Eskin, Dean T. Eurich, Sumit R. Majumdar and Jeffrey A. Johnson

    Citation: BMC Cancer 2018 18:65

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