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  1. Prostate cancer is caused by genomic aberrations in normal epithelial cells, however clinical translation of findings from analyses of cancer cells alone has been very limited. A deeper understanding of the tu...

    Authors: Stefano Mangiola, Patrick McCoy, Martin Modrak, Fernando Souza-Fonseca-Guimaraes, Daniel Blashki, Ryan Stuchbery, Simon P. Keam, Michael Kerger, Ken Chow, Chayanica Nasa, Melanie Le Page, Natalie Lister, Simon Monard, Justin Peters, Phil Dundee, Scott G. Williams…

    Citation: BMC Cancer 2021 21:846

    Content type: Research article

    Published on:

  2. The understanding of molecular changes in mCRC during treatment could be used to personalise therapeutic strategies. The aim of our study was to explore the association of circulating tumour DNA (ctDNA) with c...

    Authors: Ning Jia, Lianpeng Chang, Xin Gao, Xiaohua Shi, Xuelin Dou, Mei Guan, Yajuan Shao, Ningning Li, Yuejuan Cheng, Hongyan Ying, Zhao Sun, Yanping Zhou, Lin Zhao, Jianfeng Zhou and Chunmei Bai

    Citation: BMC Cancer 2021 21:845

    Content type: Research

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  3. Glioma is a common type of brain tumor and is classified as low and high grades according to morphology and molecules. Growing evidence has proved that long non-coding RNAs (lncRNAs) play pivotal roles in nume...

    Authors: Tianzao Huang, Yingxian Chen, Yile Zeng, Chaoyang Xu, Jinzhong Huang, Weipeng Hu, Xiangrong Chen and Huangde Fu

    Citation: BMC Cancer 2021 21:844

    Content type: Research article

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  4. Patients with lung cancer (LC) have a poor quality of life (QoL) and easily suffer from psychological diseases. Previous studies focused less on the relationship between genetic factors and QoL, depression, an...

    Authors: Yunxiang Tang, Ruike Zhang, Yinan Li, Shuyu Xu, Hao Wang, Jingzhou Xu, Lei Xiao, Yajing Wang, Jing Du, Yujia Huang and Tong Su

    Citation: BMC Cancer 2021 21:842

    Content type: Research

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  5. The tripartite motif (TRIM) family proteins exhibit oncogenic roles in various cancers. The roles of TRIM27, a member of the TRIM super family, in renal cell carcinoma (RCC) remained unexplored. In the current...

    Authors: Chengwu Xiao, Wei Zhang, Meimian Hua, Huan Chen, Bin Yang, Ye Wang and Qing Yang

    Citation: BMC Cancer 2021 21:841

    Content type: Research

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  6. The objective of this study was to investigate the survival outcomes of surgical margin width in intrahepatic cholangiocarcinoma (ICC).

    Authors: Hongzhi Liu, Lianku Lin, Ziguo Lin, Yifan Chen, Qizhen Huang, Lei Ding, Jianying Lou, Shuguo Zheng, Xinyu Bi, Jianming Wang, Wei Guo, Fuyu Li, Jian Wang, Yamin Zheng, Jingdong Li, Shi Cheng…

    Citation: BMC Cancer 2021 21:840

    Content type: Research

    Published on:

  7. Body weight management was an important component in breast cancer survivorship care. The present study described the change patterns of body weight and waist-to-hip ratio (WHR) during the first 5 years of sur...

    Authors: Yuan-Yuan Lei, Suzanne C. Ho, Carol Kwok, Ashley Cheng, Ka Li Cheung, Roselle Lee, Frankie Mo and Winnie Yeo

    Citation: BMC Cancer 2021 21:839

    Content type: Research

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  8. Tumor bed (TB) delineation based on preoperative magnetic resonance imaging (pre-MRI) fused with postoperative computed tomography (post-CT) were compared to post-CT only to define pre-MRI may aid in improving...

    Authors: Jie Jiang, Jinhu Chen, Wanhu Li, Yongqing Li, Yiru Chen, Zicheng Zhang, Chengxin Liu, Dan Han, Hongfu Sun, Baosheng Li and Wei Huang

    Citation: BMC Cancer 2021 21:838

    Content type: Research

    Published on:

  9. This study aimed to assess the clinical usefulness of 13N-ammonia and 11C- Methionine (MET) positron emission tomography (PET)/ computed tomography (CT) in the differentiation of residual/recurrent pituitary aden...

    Authors: Fangling Zhang, Qiao He, Ganhua Luo, Yali Long, Ruocheng Li, Lei Ding and Xiangsong Zhang

    Citation: BMC Cancer 2021 21:837

    Content type: Research

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  10. Immunotherapy is a crucial therapeutic approach in oncology. However, most patients with head and neck squamous cell carcinoma (HNSCC) do not derive benefit from immunotherapy. Vascular endothelial growth fact...

    Authors: Chao Zhu, Liqun Gu, Zelong Liu, Jiang Li, Mianfeng Yao and Changyun Fang

    Citation: BMC Cancer 2021 21:836

    Content type: Research

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  11. The prognosis of oral squamous cell carcinoma (OSCC) patients is difficult to predict or describe due to its high-level heterogeneity and complex aetiologic factors. Ferroptosis is a novel form of iron-depende...

    Authors: Hongyu Li, Xiliu Zhang, Chen Yi, Yi He, Xun Chen, Wei Zhao and Dongsheng Yu

    Citation: BMC Cancer 2021 21:835

    Content type: Research article

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  12. Treatment for radioiodine refractory differentiated thyroid carcinoma (RR-DTC) is challenging. The purpose of this study was to assess the efficacy and safety of ultrasound-guided implantation of radioactive 125I...

    Authors: Wei Chen, Yu kun Luo, Ying Zhang, Qing Song and Jie Tang

    Citation: BMC Cancer 2021 21:834

    Content type: Research

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  13. Epithelioid sarcomas and rhabdoid tumors are rare, aggressive malignancies with poor prognosis. Both are characterized by INI1 alterations and deregulation of growth factor receptors albeit their interaction h...

    Authors: Anne Catherine Harttrampf, Maria Eugenia Marques da Costa, Aline Renoult, Estelle Daudigeos-Dubus and Birgit Geoerger

    Citation: BMC Cancer 2021 21:833

    Content type: Research

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  14. The efficacy of olanzapine as an antiemetic agent in cancer chemotherapy has been demonstrated. However, few high-quality reports are available on the evaluation of olanzapine’s efficacy and safety at a low do...

    Authors: Senri Yamamoto, Hirotoshi Iihara, Ryuji Uozumi, Hitoshi Kawazoe, Kazuki Tanaka, Yukiyoshi Fujita, Masakazu Abe, Hisao Imai, Masato Karayama, Yoh Hayasaki, Chiemi Hirose, Takafumi Suda, Kazuto Nakamura, Akio Suzuki, Yasushi Ohno, Ken-ichirou Morishige…

    Citation: BMC Cancer 2021 21:832

    Content type: Research

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  15. Clear cell renal cell carcinoma (ccRCC) is still highly aggressive and lethal even with various therapeutic approaches. As the kidney is an iron metabolism-related organ, exploring and assessing the clinical v...

    Authors: Yingkai Hong, Mingen Lin, Dehua Ou, Zhuangkai Huang and Peilin Shen

    Citation: BMC Cancer 2021 21:831

    Content type: Research

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  16. Although various clinical trials and real-life studies have tried to explore the value of nab-paclitaxel mono-chemotherapy for metastatic breast cancer (MBC), the safety and efficacy of nab-paclitaxel remain u...

    Authors: Haili Lu, Siluo Zha, Wei Zhang, Qiang Wang, Daozhen Jiang, Xinyun Xu, Xiangmin Zheng, Ming Qiu and Chengxiang Shan

    Citation: BMC Cancer 2021 21:830

    Content type: Research article

    Published on:

  17. Diffuse large B-cell lymphoma (DLBCL) is the most frequent lymphoid neoplasm among adults,and approximately 30–40% of patients will experience relapse while 5–10% will suffer from primary refractory disease ca...

    Authors: Marijana Nesic, Mads Sønderkær, Rasmus Froberg Brøndum, Tarec Christoffer El-Galaly, Inge Søkilde Pedersen, Martin Bøgsted and Karen Dybkær

    Citation: BMC Cancer 2021 21:829

    Content type: Research

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  18. Autophagy-related proteins may predict postresection overall survival (OS) and disease-free survival (DFS) in patients with combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC).

    Authors: Daw-Shyong Perng, Chao-Ming Hung, Hung-Yu Lin, Paul Morgan, Yao-Chun Hsu, Tsung-Chin Wu, Pei-Min Hsieh, Jen-Hao Yeh, Pojen Hsiao, Chih-Yuan Lee, Yu-Chan Li, Ya-Chin Wang, Yaw-Sen Chen and Chih-Wen Lin

    Citation: BMC Cancer 2021 21:828

    Content type: Research

    Published on:

  19. Hepatocellular carcinoma (HCC) is a common cause of cancer mortality worldwide. Recent studies have shown that the polytopic enzyme membrane associated ring-CH-type finger 6 (MARCH6) participates in tumorigene...

    Authors: Jie Sun, Zheng Dong, Zhengyao Chang, Hongfei Liu, Qiyu Jiang, Deyuan Zhang, Shanshan Lu, Xiaodong Jia, Dawei Wu, Aaron Ge, Pan Zhao, Jing Wang and Yinying Lu

    Citation: BMC Cancer 2021 21:827

    Content type: Research article

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  20. Circulating tumour cell (CTC) and CTC-white blood cell (CTC-WBC) clusters are related to the prognosis of tumour patients. However, the relationship between CTC-WBC clusters and prognosis in renal cell carcino...

    Authors: Yibing Guan, Fangshi Xu, Juanhua Tian, Ke Gao, Ziyan Wan, Yiyuan Wang, Mei Gao, Zhenlong Wang and Tie Chong

    Citation: BMC Cancer 2021 21:826

    Content type: Research

    Published on:

  21. The prognosis of lung cancer with synchronous brain metastasis (LCBM) is very poor, and patients often die within a short time. However, little is known about the early mortality and related factors in patient...

    Authors: Heng Shen, Gang Deng, Qianxue Chen and Jin Qian

    Citation: BMC Cancer 2021 21:825

    Content type: Research

    Published on:

  22. The Veterans Health Administration (VHA) is the largest integrated health care system in the United States (US). Among VHA patients, the rate of use of concurrent chemoradiation therapy (CCRT) among those with...

    Authors: Anna Hung, Kyung Min Lee, Julie A. Lynch, Yanhong Li, Pradeep Poonnen, Olga V. Efimova, Bradley J. Hintze, Trudy Buckingham, Candice Yong, Brian Seal, Michael J. Kelley and Shelby D. Reed

    Citation: BMC Cancer 2021 21:824

    Content type: Research

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  23. Tumor mutation burden (TMB) is an emerging prognostic biomarker of immunotherapy for bladder cancer (BLCA). We aim at investigating radiomic features’ value in predicting the TMB status of BLCA patients.

    Authors: Xin Tang, Wen-lei Qian, Wei-feng Yan, Tong Pang, You-ling Gong and Zhi-gang Yang

    Citation: BMC Cancer 2021 21:823

    Content type: Research

    Published on:

  24. Cervical cancer, one of the most common cancers affecting females in South Africa, commonly requires a cisplatin-based-treatment regimen, which has been associated with ototoxic side effects. However, cisplati...

    Authors: Jessica Paken, Cyril D. Govender, Mershen Pillay, Birhanu T. Ayele and Vikash Sewram

    Citation: BMC Cancer 2021 21:822

    Content type: Research

    Published on:

  25. Cell division cycle 25A (CDC25A) is a well-recognized regulator of cell cycle progression and is involved in cancer development. This work focused on the function of CDC25A in cervical cancer cell growth and t...

    Authors: Jinhong Qi, Li Zhou, Dongqing Li, Jingyuan Yang, He Wang, Huifang Cao, Yunlan Huang, Zhiming Zhang, Linlin Chang, Chenhao Zhu, Juntong Zhan and Yong Yuan

    Citation: BMC Cancer 2021 21:819

    Content type: Research

    Published on:

  26. Gemcitabine plus platinum as the first-line chemotherapy for cholangiocarcinoma (CCA) has limited efficacy. The aim of this study was to evaluate the effectiveness of modified FOLFIRINOX (mFOLFIRINOX) compared...

    Authors: Lu Zou, Xuechuan Li, Xiangsong Wu, Jiujie Cui, Xuya Cui, Xiaoling Song, Tai Ren, Xusheng Han, Yidi Zhu, Huaifeng Li, Wenguang Wu, Xu’an Wang, Wei Gong, Liwei Wang, Maolan Li, Wan Yee Lau…

    Citation: BMC Cancer 2021 21:818

    Content type: Research

    Published on:

  27. Since it’s a challenging task to precisely predict the prognosis of patients with hepatocellular carcinoma (HCC). We developed a nomogram based on a novel indicator GMWG [(Geometric Mean of gamma-glutamyltrans...

    Authors: Liying Ren, Dongbo Chen, Wentao Xu, Tingfeng Xu, Rongyu Wei, Liya Suo, Yingze Huang, Hongsong Chen and Weijia Liao

    Citation: BMC Cancer 2021 21:817

    Content type: Research

    Published on:

  28. A significant proportion of newly diagnosed patients with cutaneous squamous cell carcinoma (cSCC) have metastasis and eventually die of the disease, necessitating the exploration of novel biomarkers for early...

    Authors: Hui Wang, Hong Li, Qingtao Yan, Sumei Gao, Jianfang Gao, Zhenhua Wang and Yi Sun

    Citation: BMC Cancer 2021 21:816

    Content type: Research

    Published on:

  29. Changes in calcium metabolism and calcium urinary excretion during chemotherapy have not been thoroughly assessed in patients with early breast cancer (EBC), a population who frequently present vitamin D insuf...

    Authors: Marie Viala, Nelly Firmin, Célia Touraine, Stéphane Pouderoux, Manon Metge, Lobna Rifai, Gilles Romieu, Hélène de Forges, Lise Roca, Séverine Guiu, Véronique D’Hondt and William Jacot

    Citation: BMC Cancer 2021 21:815

    Content type: Research

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  30. The molecular prognostic biomarkers of clear cell renal cell carcinoma (ccRCC) are still unknown. We aimed at researching the candidate biomarkers and potential therapeutic targets of ccRCC.

    Authors: Jing Quan, Yuchen Bai, Yunbei Yang, Er Lei Han, Hong Bai, Qi Zhang and Dahong Zhang

    Citation: BMC Cancer 2021 21:814

    Content type: Research

    Published on:

  31. This study was aimed to evaluate the value of DNA index(DI) among pediatric acute lymphoblastic leukemia (ALL) treated on Children’s Oncology Group (COG) protocols between 2000 and 2015.

    Authors: Kun-yin Qiu, Xiong-yu Liao, Zhan-wen He, Ruo-hao Wu, Yang Li, Lu-hong Xu, Dun-hua Zhou and Jian-pei Fang

    Citation: BMC Cancer 2021 21:813

    Content type: Research

    Published on:

  32. Adenoid cystic carcinoma is a rare form of head and neck cancer with a slow, but aggressive growth pattern which remains a challenge for local tumor control. Based on phase II data, radiation treatment using p...

    Authors: Kristin Lang, Sebastian Adeberg, Semi Harrabi, Thomas Held, Meinhard Kieser, Jürgen Debus and Klaus Herfarth

    Citation: BMC Cancer 2021 21:812

    Content type: Study protocol

    Published on:

  33. Cancer-related fatigue (CRF) is one of the most common and distressing symptoms in people with cancer. Although efficacy of interventions for CRF have been extensively investigated, less has been done to ensur...

    Authors: Oluwaseyifunmi Andi Agbejule, Nicolas H. Hart, Stuart Ekberg, Koczwara Bogda, Rahul Ladwa, Camilla Simonsen, Elizabeth P. Pinkham and Raymond Javan Chan

    Citation: BMC Cancer 2021 21:809

    Content type: Research article

    Published on:

  34. Though the gut microbiome has been associated with efficacy of immunotherapy (ICI) in certain cancers, similar findings have not been identified for microbiomes from other body sites and their correlation to t...

    Authors: Justin Chau, Meeta Yadav, Ben Liu, Muhammad Furqan, Qun Dai, Shailesh Shahi, Arnav Gupta, Keri Nace Mercer, Evan Eastman, Taher Abu Hejleh, Carlos Chan, George J. Weiner, Catherine Cherwin, Sonny T. M. Lee, Cuncong Zhong, Ashutosh Mangalam…

    Citation: BMC Cancer 2021 21:808

    Content type: Research article

    Published on:

  35. Trastuzumab has changed the prognosis of HER2+ breast cancer. We aimed to investigate the prognosis of ER+/HER2+ patients treated with trastuzumab, thus to guide escalation endocrine treatment in ER+ breast ca...

    Authors: Shuai Li, Jiayi Wu, Ou Huang, Jianrong He, Li Zhu, Weiguo Chen, Yafen Li, Xiaosong Chen and Kunwei Shen

    Citation: BMC Cancer 2021 21:807

    Content type: Research

    Published on:

  36. The incidence rate of adenocarcinoma of the oesophagogastric junction (AEG) has significantly increased over the past decades, with a steady increase in morbidity. The aim of this study was to explore a variet...

    Authors: Jun Wang, Le Shi, Jing Chen, Beidi Wang, Jia Qi, Guofeng Chen, Muxing Kang, Hang Zhang, Xiaoli Jin, Yi Huang, Zhiqing Zhao, Jianfeng Chen, Bin Song and Jian Chen

    Citation: BMC Cancer 2021 21:806

    Content type: Research

    Published on:

  37. Cancerous cells can recycle metabolic ammonium for their growth. As this ammonium has a low nitrogen isotope ratio (15N/14N), its recycling may cause cancer tissue to have lower 15N/14N than surrounding healthy t...

    Authors: M. Straub, D. M. Sigman, A. Auderset, J. Ollivier, B. Petit, B. Hinnenberg, F. Rubach, S. Oleynik, M.-C. Vozenin and A. Martínez-García

    Citation: BMC Cancer 2021 21:805

    Content type: Research

    Published on:

  38. In the absence of practical and reliable predictors for whether the endocervical curettage (ECC) procedure should be performed, decisions regarding patient selection are usually based on the colposcopists’ cli...

    Authors: Yuanxing Li, Haixia Luo, Xiu Zhang, Jingjing Chang, Yueyang Zhao, Jing Li, Dongyan Li and Wei Wang

    Citation: BMC Cancer 2021 21:804

    Content type: Research

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  39. Afatinib is approved globally for EGFR-TKI treatment-naïve patients with EGFR mutation-positive non-small cell lung cancer (NSCLC). In this Korean expanded access program, we evaluated its ‘real-world’ safety and...

    Authors: Keunchil Park, Jin-Soo Kim, Joo-Hang Kim, Young-Chul Kim, Hoon-Gu Kim, Eun Kyung Cho, Jong-Youl Jin, Miyoung Kim, Angela Märten and Jin-Hyoung Kang

    Citation: BMC Cancer 2021 21:802

    Content type: Research

    Published on:

  40. DNA methylation alteration is frequently observed in Lung adenocarcinoma (LUAD) and may play important roles in carcinogenesis, diagnosis, and prognosis. Thus, this study aimed to construct a reliable methylat...

    Authors: Xuelong Wang, Bin Zhou, Yuxin Xia, Jianxin Zuo, Yanchao Liu, Xin Bi, Xiong Luo and Chengwei Zhang

    Citation: BMC Cancer 2021 21:801

    Content type: Research article

    Published on:

  41. Cancer cachexia causes significant morbidity and mortality in advanced lung cancer patients. Clinical benefit of β-hydroxy-β-methylbutyrate, arginine, and glutamine (HMB/Arg/Gln) was assessed in newly diagnose...

    Authors: Jennifer Pascoe, Aimee Jackson, Charlotte Gaskell, Claire Gaunt, Joyce Thompson, Lucinda Billingham and Neil Steven

    Citation: BMC Cancer 2021 21:800

    Content type: Research article

    Published on:

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