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  1. Content type: Research article

    The addition of high-dose cytarabine to the treatment of mantle cell lymphoma (MCL) has significantly prolonged survival of patients, but relapses are common and are normally associated with increased resistan...

    Authors: Catja Freiburghaus, Venera Kuci Emruli, Angelica Johansson, Christian Winther Eskelund, Kirsten Grønbæk, Roger Olsson, Fredrik Ek, Mats Jerkeman and Sara Ek

    Citation: BMC Cancer 2018 18:466

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  2. Content type: Research article

    Both the adenoma detection rate (ADR) and proximal serrated polyp detection rate (PSPDR) vary among endoscopists. It is unclear how these variations influence colorectal cancer (CRC) screening effectiveness. W...

    Authors: Maxime E. S. Bronzwaer, Marjolein J. E. Greuter, Arne G. C. Bleijenberg, Joep E. G. IJspeert, Evelien Dekker and Veerle M. H. Coupé

    Citation: BMC Cancer 2018 18:465

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  3. Content type: Research article

    Embryonic Liver Fodrin (ELF) is an adaptor protein of transforming growth factor (TGF-β) signaling cascade. Disruption of ELF results in mislocalization of Smad3 and Smad4, leading to compromised TGF-β signali...

    Authors: Fei Ji, Zhi-heng Zhang, Yi Zhang, Shun-Li Shen, Qing-Hua Cao, Long-Juan Zhang, Shao-Qiang Li, Bao-Gang Peng, Li-Jian Liang and Yun-Peng Hua

    Citation: BMC Cancer 2018 18:460

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  4. Content type: Case report

    Radiogenic angiosarcoma of the breast (RASB) is a rare late sequela of local irradiation of the breast or chest wall after breast cancer. The prognosis of women with RASB is poor and there is no standardized t...

    Authors: Askin Dogan, Peter Kern, Beate Schultheis, Günther Häusler, Günther A. Rezniczek and Clemens B. Tempfer

    Citation: BMC Cancer 2018 18:463

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  5. Content type: Research article

    Programmed death-ligand 1 (PD-L1) is an immunosuppressor that plays an important role in cancer treatments. Although majority of the studies demonstrated that PD-L1 expression was regulated by cellular intrins...

    Authors: Chenlu Zhang, Zhi Li, Ling Xu, Xiaofang Che, Ti Wen, Yibo Fan, Ce Li, Shuo Wang, Yu Cheng, Xiaoxun Wang, Xiujuan Qu and Yunpeng Liu

    Citation: BMC Cancer 2018 18:462

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  6. Content type: Research article

    The standard treatment for cervical adenocarcinoma in situ (AIS) is hysterectomy, which is a more aggressive treatment than that used for squamous intraepithelial lesions. Several previous studies have primari...

    Authors: Huimin Bai, Jun Liu, Qiuxi Wang, Ying Feng, Tong Lou, Shuzhen Wang, Yue Wang, Mulan Jin and Zhenyu Zhang

    Citation: BMC Cancer 2018 18:461

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  7. Content type: Research article

    Pancreatic ductal adenocarcinoma (PDA) remains the most aggressive cancers with a 5-year survival below 10%. Systemic delivery of chemotherapy drugs has severe side effects in patients with PDA and does not si...

    Authors: Shu-ta Wu, Anthony J. Fowler, Corey B. Garmon, Adam B. Fessler, Joshua D. Ogle, Kajal R. Grover, Bailey C. Allen, Chandra D. Williams, Ru Zhou, Mahboubeh Yazdanifar, Craig A. Ogle and Pinku Mukherjee

    Citation: BMC Cancer 2018 18:457

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  8. Content type: Study protocol

    Advances in genomics offer promise for earlier detection or prevention of cancer, by personalisation of medical care tailored to an individual’s genomic risk status. However genome sequencing can generate an u...

    Authors: Megan Best, Ainsley J. Newson, Bettina Meiser, Ilona Juraskova, David Goldstein, Kathy Tucker, Mandy L. Ballinger, Dominique Hess, Timothy E. Schlub, Barbara Biesecker, Richard Vines, Kate Vines, David Thomas, Mary-Anne Young, Jacqueline Savard, Chris Jacobs…

    Citation: BMC Cancer 2018 18:454

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  9. Content type: Study protocol

    Advanced cancer significantly impacts quality of life of patients and families as they cope with symptom burden, treatment decision-making, uncertainty and costs of treatment. In Singapore, information about t...

    Authors: Irene Teo, Ratna Singh, Chetna Malhotra, Semra Ozdemir, Rebecca A. Dent, Nesaretnam Barr Kumarakulasinghe, Wee Lee Yeo, Yin Bun Cheung, Rahul Malhotra, Ravindran Kanesvaran, Alethea Chung Pheng Yee, Noreen Chan, Huei Yaw Wu, Soh Mun Chin, Hum Yin Mei Allyn, Grace Meijuan Yang…

    Citation: BMC Cancer 2018 18:459

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  10. Content type: Research article

    5-Fluorouracil (5FU), Folinic acid (FA), and Oxaliplatin (FOLFOX) or 5FU, FA, and Irinotecan (FOLFIRI) are standard regimens for palliative chemotherapy of metastatic colon cancer. Since data showing the influ...

    Authors: Stefan Munker, Michael Gerken, Petra Fest, Claudia Ott, Elisabeth Schnoy, Stefan Fichtner-Feigl, Philipp Wiggermann, Martin Vogelhuber, Wolfgang Herr, Christian Stroszczynski, Hans Jürgen Schlitt, Matthias Evert, Michael Reng, Monika Klinkhammer-Schalke and Andreas Teufel

    Citation: BMC Cancer 2018 18:455

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  11. Content type: Study protocol

    Cosmetic result in breast cancer surgery is gaining increased interest. Currently, some 30–40% of the patients treated with breast conserving surgery (BCS) are dissatisfied with their final cosmetic result. In...

    Authors: Coriene J. L. M. Catsman, Martinus A. Beek, Adri C. Voogd, Paul G. H. Mulder and Ernest J. T. Luiten

    Citation: BMC Cancer 2018 18:456

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  12. Content type: Research article

    DNA damage repair is a complex process, which can trigger the development of cancer if disturbed. In this study, we hypothesize a role of variants in the ATM, H2AFX and MRE11 genes in determining breast cancer (B...

    Authors: Marta Podralska, Iwona Ziółkowska-Suchanek, Magdalena Żurawek, Agnieszka Dzikiewicz-Krawczyk, Ryszard Słomski, Jerzy Nowak, Agnieszka Stembalska, Karolina Pesz and Maria Mosor

    Citation: BMC Cancer 2018 18:452

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  13. Content type: Study protocol

    Initial staging of gastric cancer consists of computed tomography (CT) and gastroscopy. In locally advanced (cT3–4) gastric cancer, fluorodeoxyglucose positron emission tomography with CT (FDG-PET/CT or PET) a...

    Authors: H. J. F. Brenkman, E. C. Gertsen, E. Vegt, R. van Hillegersberg, M. I. van Berge Henegouwen, S. S. Gisbertz, M. D. P. Luyer, G. A. P. Nieuwenhuijzen, J. J. B. van Lanschot, S. M. Lagarde, W. O. de Steur, H. H. Hartgrink, J. H. M. B. Stoot, K. W. E. Hulsewe, E. J. Spillenaar Bilgen, M. J. van Det…

    Citation: BMC Cancer 2018 18:450

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  14. Content type: Research article

    We previously reported that clioquinol acts as a zinc ionophore and inhibits the NF-κB signalling pathway. Other research has demonstrated that zinc deficiency plays a vital role in the occurrence and developm...

    Authors: Shan Lu, Yuan Ke, Chaoyan Wu, Yahua Zhong, Conghua Xie, Yunfeng Zhou, Fuxiang Zhou and Haijun Yu

    Citation: BMC Cancer 2018 18:448

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  15. Content type: Research article

    The objective of study was to determine the effect of anthracycline dose reduction and chemotherapy delays on 5-year overall survival in patients with stage I-III breast cancer, to establish the impact of mole...

    Authors: Sigita Liutkauskiene, Saulius Grizas, Kristina Jureniene, Jorune Suipyte, Akvile Statnickaite and Elona Juozaityte

    Citation: BMC Cancer 2018 18:453

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  16. Content type: Research article

    Some patients develop recurrence after curative resection and adjuvant chemotherapy. S-1, an oral fluoropyrimidine, is one of the standard regimens in adjuvant chemotherapy, and is also used in first-line trea...

    Authors: Seiji Ito, Yasuo Ohashi and Mitsuru Sasako

    Citation: BMC Cancer 2018 18:449

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  17. Content type: Research article

    To evaluate the efficacy and safety of stereotactic body radiation therapy (SBRT) in patients with small hepatocellular carcinoma(sHCC) who were ineligible for surgery or ablation therapies.

    Authors: Tao Zhang, Jing Sun, Weiping He, Huan Li, Junjie Piao, Huijun Xu and Xuezhang Duan

    Citation: BMC Cancer 2018 18:451

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  18. Content type: Research article

    To identify the incidence, recurrence pattern and prognosis of brain metastases (BM) among women with metastatic triple negative breast cancer (mTNBC) treated consecutively at a single institution during a 7-y...

    Authors: Jia Jin, Yu Gao, Jian Zhang, Leiping Wang, Biyun Wang, Jun Cao, Zhimin Shao and Zhonghua Wang

    Citation: BMC Cancer 2018 18:446

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  19. Content type: Research article

    AB0 blood groups and Rhesus factor expression have been associated with carcinogenesis, response to treatment and tumor progression in several malignancies. The aim of the present study was to test the hypothe...

    Authors: Veronika Seebacher, Stephan Polterauer, Alexander Reinthaller, Heinz Koelbl, Regina Achleitner, Astrid Berger and Nicole Concin

    Citation: BMC Cancer 2018 18:447

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  20. Content type: Research article

    Previous studies have suggested that metformin may be useful for preventing and treating endometrial cancer (EC), while the results have been inconsistent. This systematic review and meta-analysis aimed to inv...

    Authors: Danxia Chu, Jie Wu, Kaili Wang, Mengling Zhao, Chunfang Wang, Liuxia Li and Ruixia Guo

    Citation: BMC Cancer 2018 18:438

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  21. Content type: Research article

    Survival rates for upper gastrointestinal (GI) cancer are poor since many are diagnosed at advanced stages. Fast track endoscopy has been introduced to prompt diagnosis for patients with alarm symptoms that co...

    Authors: Sanne Rasmussen, Peter Fentz Haastrup, Kirubakaran Balasubramaniam, René DePont Christensen, Jens Søndergaard and Dorte Ejg Jarbøl

    Citation: BMC Cancer 2018 18:440

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  22. Content type: Research article

    The prognostic effect of elevated systemic inflammatory markers, including neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), remains controversial in cancer patients. This meta-analysis wa...

    Authors: Ying Zhu, Sanqin Zhou, Yang Liu, Lingyun Zhai and Xiwen Sun

    Citation: BMC Cancer 2018 18:443

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