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  1. Content type: Research article

    Significant advances in the molecular profiling of gliomas, led the 2016 World Health Organization (WHO) Classification to include, for the first-time, molecular biomarkers in glioma diagnosis: IDH mutations and ...

    Authors: Cheila Brito, Ana Azevedo, Susana Esteves, Ana Rita Marques, Carmo Martins, Ilda Costa, Manuela Mafra, José M. Bravo Marques, Lúcia Roque and Marta Pojo

    Citation: BMC Cancer 2019 19:968

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  2. Content type: Case report

    Patients with metastatic renal carcinoma frequently have pre-existing renal impairment and not infrequently develop worsening renal function as a complication of their treatment. The presence of pancreatic met...

    Authors: Karin Purshouse, Sarah Chamberlain, Maria Soares, Mark Tuthill, Andrew Protheroe and David R. Mole

    Citation: BMC Cancer 2019 19:967

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  3. Content type: Case report

    Lymphoma and dysplasia are rare complications of long-standing Crohn’s disease. We report an exceptional case of a synchronous intestinal marginal zone B-cell lymphoma (MALT lymphoma) and colonic adenoma in a ...

    Authors: Amal Bennani, Ghizlane Kharrasse, Miry Achraf, Khanoussi Wafa, Ismaili Zahi, Kamaoui Imane and Bouziane Mohamed

    Citation: BMC Cancer 2019 19:966

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  4. Content type: Research article

    Sarcomatoid carcinoma of unknown primary (SCUP) is a rare entity of either poorly differentiated carcinoma with sarcoma-like differentiation or a true mixed lineage neoplasm. Limited data regarding clinicopath...

    Authors: Ryan W. Huey, Shalini Makawita, Lianchun Xiao, Aurelio Matamoros, Jeannelyn S. Estrella, Michael J. Overman, Gauri R. Varadhachary and Kanwal Raghav

    Citation: BMC Cancer 2019 19:965

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  5. Content type: Research article

    CpG Island Methylator Phenotype (CIMP) is an epigenetic phenotype in CRC characterized by hypermethylation of CpG islands in promoter regions of tumor suppressor genes, leading to their transcriptional silenci...

    Authors: Shailesh Mahesh Advani, Pragati Shailesh Advani, Derek W. Brown, Stacia M. DeSantis, Krittiya Korphaisarn, Helena M. VonVille, Jan Bressler, David S. Lopez, Jennifer S. Davis, Carrie R. Daniel, Amir Mehrvarz Sarshekeh, Dejana Braithwaite, Michael D. Swartz and Scott Kopetz

    Citation: BMC Cancer 2019 19:964

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  6. Content type: Research article

    Overexpression of fibroblast growth factor receptor 3 (FGFR3) has been linked to tumor progression in many types of cancer. The role of FGFR3 in melanoma remains unclear. In this study, we aimed to uncover the...

    Authors: Lei Li, Shuai Zhang, Hao Li and Haiyan Chou

    Citation: BMC Cancer 2019 19:963

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  7. Content type: Research article

    We previously reported the synergistic effect of S-1 and eribulin in preclinical models. In addition, our phase I study revealed the recommended dose for the phase II study of the combination therapy in advanc...

    Authors: Tsutomu Iwasa, Junji Tsurutani, Satomi Watanabe, Ryoji Kato, Yutaka Mizuno, Yasuyuki Kojima, Tsutomu Takashima, Nobuki Matsunami, Takashi Morimoto, Jun Yamamura, Shoichiro Ohtani, Yuko Tanabe, Tetsuhiro Yoshinami, Toshimi Takano, Yoshifumi Komoike and Kazuhiko Nakagawa

    Citation: BMC Cancer 2019 19:962

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  8. Content type: Research article

    Neuroblastoma is the most common extra-cranial solid tumor among children. Despite intensive treatment, patients with advanced disease mostly experience dismal outcomes. Here, we proposed the use of topotecan ...

    Authors: Piya Rujkijyanont, Apichat Photia, Chanchai Traivaree, Chalinee Monsereenusorn, Usanarat Anurathapan, Panya Seksarn, Darintr Sosothikul, Piti Techavichit, Kleebsabai Sanpakit, Kamon Phuakpet, Surapon Wiangnon, Thirachit Chotsampancharoen, Su-on Chainansamit, Somjai Kanjanapongkul, Arunotai Meekaewkunchorn and Suradej Hongeng

    Citation: BMC Cancer 2019 19:961

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  9. Content type: Case report

    Neuroendocrine tumors (NETs) are heterogeneous, widely distributed tumors arising from neuroendocrine cells. Gastrointestinal (GI)-NETs are the most common and NETs of the rectum represent 15, 2% of gastrointe...

    Authors: Gemma Bruera, Antonio Giuliani, Lucia Romano, Alessandro Chiominto, Alessandra Di Sibio, Stefania Mastropietro, Pierluigi Cosenza, Enrico Ricevuto, Mario Schietroma and Francesco Carlei

    Citation: BMC Cancer 2019 19:960

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  10. Content type: Research article

    HER3 mediates drug resistance against epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs), resulting in tumor relapse in lung cancers. Previously, we demonstrated that EGFR induces HER3 o...

    Authors: Yi-Fang Chang, Ken-Hong Lim, Ya-Wen Chiang, Zong-Lin Sie, Jungshan Chang, Ai-Sheng Ho and Chun-Chia Cheng

    Citation: BMC Cancer 2019 19:959

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  11. Content type: Research article

    We analyzed the changes in permeability of endothelial cell layers after photon irradiation, with a focus on the metalloproteases ADAM10 and ADAM17, and on VE-cadherin, components crucial for the integrity of ...

    Authors: Pascaline Nguemgo Kouam, Günther A. Rezniczek, Irenäus A. Adamietz and Helmut Bühler

    Citation: BMC Cancer 2019 19:958

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  12. Content type: Research article

    99mTc-Rituximab is a new specific radiopharmaceutical that binds to the CD20 receptor which is highly expressed on the surface of B cells. We conducted a study in which 99mTc-Rituximab was compared with filtered

    Authors: Jing-Jie Zhang, Wan-Chun Zhang, Cai-Xia An, Xiao-Min Li and Le Ma

    Citation: BMC Cancer 2019 19:956

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  13. Content type: Research article

    The efficacy of hepatic arterial infusion chemotherapy (HAIC) for advanced hepatocellular carcinoma (HCC) remains unclear. We conducted a multi-center randomized phase II study comparing a sequential HAIC-sora...

    Authors: Masaaki Kondo, Manabu Morimoto, Satoshi Kobayashi, Shinichi Ohkawa, Hisashi Hidaka, Takahide Nakazawa, Hiroshi Aikata, Takeshi Hatanaka, Daichi Takizawa, Kotaro Matsunaga, Chiaki Okuse, Michihiro Suzuki, Masataka Taguri, Takako Ishibashi, Kazushi Numata, Shin Maeda…

    Citation: BMC Cancer 2019 19:954

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  14. Content type: Research article

    Gestational trophoblastic disease (GTD) is a heterogeneous group of diseases developed from trophoblasts. ASPP (Ankyrin-repeat, SH3-domain and proline-rich region containing protein) family proteins, ASPP1 and...

    Authors: Ka-Kui Chan, Esther Shuk-Ying Wong, Ivy Tsz-Lo Wong, Claire Ling-Yang Cheung, Oscar Gee-Wan Wong, Hextan Yuen-Sheung Ngan and Annie Nga-Yin Cheung

    Citation: BMC Cancer 2019 19:953

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  15. Content type: Research article

    Lymph-node (LN) metastasis is an important prognostic factor in resected pancreatic cancer. In this study, the prognostic value of American Joint Committee on Cancer (AJCC) 8th edition N stage, lymph-node rati...

    Authors: Min Su You, Sang Hyub Lee, Young Hoon Choi, Bang-sup Shin, Woo Hyun Paik, Ji Kon Ryu, Yong-Tae Kim, Dong Kee Jang, Jun Kyu Lee, Wooil Kwon, Jin-Young Jang and Sun-Whe Kim

    Citation: BMC Cancer 2019 19:952

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  16. Content type: Research article

    Strong associations exist between Balkan endemic nephropathy (BEN) and upper urothelial carcinomas (UUCs). However, the common etiology between the two remains unclear and there are no studies to date that vis...

    Authors: Danira Medunjanin, Zdenko Sonicki, John E. Vena, Ante Cvitkovic and Sara Wagner Robb

    Citation: BMC Cancer 2019 19:950

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  17. Content type: Research article

    In the quest for new anti-cancer drugs, the drug discovery process has shifted to screening of active ingredients in traditional eastern medicine. Matrine is an active alkaloid isolated from plants of the Soph...

    Authors: Yuming Zou, Melika Sarem, Shengnan Xiang, Honggang Hu, Weidong Xu and V. Prasad Shastri

    Citation: BMC Cancer 2019 19:949

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  18. Content type: Research article

    Transcription-coupled nucleotide excision repair (TC-NER) plays a prominent role in the removal of DNA adducts induced by platinum-based chemotherapy reagents. Cockayne syndrome protein B (CSB), the master sen...

    Authors: Zhenbang Yang, Chunling Liu, Hongjiao Wu, Yuning Xie, Hui Gao and Xuemei Zhang

    Citation: BMC Cancer 2019 19:948

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  19. Content type: Research article

    Quality of life among prostate cancer survivors varies by socio-demographic factors and treatment type received; however, less in known about differences in functional outcomes by method of presentation. We in...

    Authors: David W. Donnelly, Linda C. Vis, Therese Kearney, Linda Sharp, Damien Bennett, Sarah Wilding, Amy Downing, Penny Wright, Eila Watson, Richard Wagland, William R. Cross, Malcolm D. Mason, Sabine Siesling, Jeannette G. van Manen, Adam W. Glaser and Anna Gavin

    Citation: BMC Cancer 2019 19:947

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  20. Content type: Research article

    Biliary rhabdomyosarcoma (RMS) is the most common biliary tumor in children. The management of affected patients contains unique challenges because of the rarity of this tumor entity and its critical location ...

    Authors: Cristian Urla, Steven W. Warmann, Monika Sparber-Sauer, Andreas Schuck, Ivo Leuschner, Thomas Klingebiel, Gunnar Blumenstock, Guido Seitz, Ewa Koscielniak and Jörg Fuchs

    Citation: BMC Cancer 2019 19:945

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  21. Content type: Research article

    Protein tyrosine phosphatase non-receptor 12 (PTPN12) is ubiquitously tyrosine phosphatase with tumor suppressive properties.

    Authors: Sören A. Weidemann, Charlotte Sauer, Andreas M. Luebke, Christina Möller-Koop, Stefan Steurer, Claudia Hube-Magg, Franziska Büscheck, Doris Höflmayer, Maria Christina Tsourlakis, Till S. Clauditz, Ronald Simon, Guido Sauter, Cosima Göbel, Patrick Lebok, David Dum, Christoph Fraune…

    Citation: BMC Cancer 2019 19:944

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  22. Content type: Debate

    A cancer diagnosis can have a substantial impact on mental health and wellbeing. Depression and anxiety may hinder cancer treatment and recovery, as well as quality of life and survival. We argue that more res...

    Authors: Claire L. Niedzwiedz, Lee Knifton, Kathryn A. Robb, Srinivasa Vittal Katikireddi and Daniel J. Smith

    Citation: BMC Cancer 2019 19:943

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  23. Content type: Research article

    Studies on relationship between tubal ligation and endometrial cancer have led to contradictory findings. In several studies, however, a reduced endometrial cancer risk was suggested following tubal ligation. ...

    Authors: Laleh Loghmani, Nafise Saedi, Reza Omani-Samani, Saeid Safiri, Mahdi Sepidarkish, Saman Maroufizadeh, Arezoo Esmailzadeh, Maryam Shokrpour, Esmaeil Khedmati Morasae and Amir Almasi-Hashiani

    Citation: BMC Cancer 2019 19:942

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  24. Content type: Study protocol

    Paclitaxel is used in second-line conventional chemotherapies to manage patients with unresectable advanced gastric cancer (GC). Paclitaxel-induced peripheral neuropathy is a known adverse event leading to tre...

    Authors: Hiroaki Tanioka, Takeshi Nagasaka, Futoshi Uno, Masafumi Inoue, Hiroyuki Okita, Yosuke Katata, Hiromitsu Kanzaki, Hidekazu Kuramochi, Hironaga Satake, Yoshiaki Shindo, Akira Doi, Jyunichiro Nasu, Haruhiro Yamashita and Yoshiyuki Yamaguchi

    Citation: BMC Cancer 2019 19:941

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  25. Content type: Research article

    In Brazil, 211 thousand (16.14%) of all death certificates in 2016 identified cancer as the underlying cause of death, and it is expected that around 320 thousand will receive a cancer diagnosis in 2019. We ai...

    Authors: Alessandro Bigoni, José Leopoldo Ferreira Antunes, Elisabete Weiderpass and Kristina Kjærheim

    Citation: BMC Cancer 2019 19:940

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  26. Content type: Research article

    This preliminary study aimed to examine the feasibility of sentinel lymph node biopsy (SLNB) using contrast-enhanced ultrasound (CEUS) vs. indocyanine green fluorescence (ICG), combined with blue dye in patien...

    Authors: Yidong Zhou, Yan Li, Feng Mao, Jing Zhang, Qingli Zhu, Songjie Shen, Yan Lin, Xiaohui Zhang, He Liu, Mengsu Xiao, Yuxin Jiang and Qiang Sun

    Citation: BMC Cancer 2019 19:939

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  27. Content type: Research article

    Intra-arterial therapy with embolics is established for the treatment of malignancies of the liver. However, there are no studies comparing the different effects of various embolics used in clinical practice. ...

    Authors: Christian Ziemann, Jonas Roller, Markus M. Malter, Kira Keller, Otto Kollmar, Matthias Glanemann, Michael D. Menger and Jens Sperling

    Citation: BMC Cancer 2019 19:938

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  28. Content type: Research article

    We aimed to investigate the correlation of Circ-SMARCA5 with disease severity and prognosis in multiple myeloma (MM), and its underlying mechanisms in regulating cell proliferation and apoptosis.

    Authors: Haiyan Liu, Yan Wu, Shunye Wang, Jie Jiang, Chenlu Zhang, Yijing Jiang, Xingfeng Wang, Lewen Hong and Hongming Huang

    Citation: BMC Cancer 2019 19:937

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  29. Content type: Research article

    Although extensive use of tyrosine kinase inhibitors has resulted in high and durable response rate and prolonged survival time in patients with BCR-ABL1 positive chronic myeloid leukemia (CML) and acute leuke...

    Authors: Zhanglin Zhang, Zhiwei Chen, Mei Jiang, Shuyuan Liu, Yang Guo, Lagen Wan and Fei Li

    Citation: BMC Cancer 2019 19:935

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  30. Content type: Research article

    Leukemia is a cancer of blood and bone marrow cells, causing about 300,000 deaths worldwide. Photodynamic therapy (PDT) is a promising alternative for the treatment of malignant tumors. KillerRed is a genetica...

    Authors: Meng Yuan, Chengcheng Liu, Jiao Li, Wenpeng Ma, Xiaozhuo Yu, Ping Zhang and Yanhong Ji

    Citation: BMC Cancer 2019 19:934

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  31. Content type: Research article

    Prognostic assessment is crucial for optimal treatment. The aim of our study was to investigate the potential impact of estrogen receptor-α (ER-α) and progesterone receptor (PR) on the prognosis of colorectal ...

    Authors: Shu-Biao Ye, Yi-Kan Cheng, Lin Zhang, Xue-Ping Wang, Lei Wang and Ping Lan

    Citation: BMC Cancer 2019 19:933

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  32. Content type: Research article

    To investigate the implications of prophylactic intraoperative Hyperthermic Intraperitoneal Chemotherapy (HIPEC) with D2 radical gastrectomy for locally advanced Gastric Cancer (AGC) in a randomized case contr...

    Authors: Maneesh Kumarsing Beeharry, Zheng-Lun Zhu, Wen-Tao Liu, Xue-Xin Yao, Min Yan and Zheng-Gang Zhu

    Citation: BMC Cancer 2019 19:932

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  33. Content type: Research article

    A high prevalence of postoperative complications is closely associated with a worse short- and long-term outcome. This current study aimed to investigate potential risk factors including albumin-to-fibrinogen ...

    Authors: Xuexue You, Qun Zhou, Jie Song, Linguang Gan, Junping Chen and Huachun Shen

    Citation: BMC Cancer 2019 19:931

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  34. Content type: Research article

    The Foxo3 gene, belonging to the forkhead family, is one of the classes of transcription factors characterized by a forkhead DNA-binding domain, which usually considered being a cancer suppressor gene. Circ-Foxo3

    Authors: Jiao Zhou, Ling-Yu Zhou, Xi Tang, Jing Zhang, Ling-Ling Zhai, Yun Yun Yi, Jing Yi, Jiang Lin, Jun Qian and Zhao-Qun Deng

    Citation: BMC Cancer 2019 19:930

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  35. Content type: Research article

    Preoperative 5-FU-based chemoradiation is currently a standard treatment for advanced rectal cancer, particularly in Western countries. Although it reduced the local recurrence, it could not necessarily improv...

    Authors: Tsunekazu Mizushima, Masataka Ikeda, Takeshi Kato, Atsuyo Ikeda, Junichi Nishimura, Taishi Hata, Chu Matsuda, Taroh Satoh, Masaki Mori and Yuichiro Doki

    Citation: BMC Cancer 2019 19:929

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  36. Content type: Research article

    Ovarian cancer is the main cause of gynecological cancer-associated death. However, 5-year survival rates differ dramatically between the five main ovarian carcinoma histotypes. Therefore, we need to have a be...

    Authors: Hanna Engqvist, Toshima Z. Parris, Anikó Kovács, Szilárd Nemes, Elisabeth Werner Rönnerman, Shahin De Lara, Jana Biermann, Karin Sundfeldt, Per Karlsson and Khalil Helou

    Citation: BMC Cancer 2019 19:928

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  37. Content type: Research article

    The clinical target volume (CTV) for postoperative radiotherapy for thoracic esophageal squamous cell carcinoma (TESCC) needs to be defined. The study aim was to map metastatic lymph nodes (LNMs) in a computed...

    Authors: Jing Yu, Wen Ouyang, Chunyang Li, Jiuling Shen, Yu Xu, Junhong Zhang and Conghua Xie

    Citation: BMC Cancer 2019 19:927

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  38. Content type: Research article

    Reproductive characteristics are well-established risk factors for breast cancer, but the underlying mechanisms are not fully resolved. We hypothesized that altered DNA methylation, measured in tumor tissue, c...

    Authors: Lauren E. McCullough, Lindsay J. Collin, Kathleen Conway, Alexandra J. White, Yoon Hee Cho, Sumitra Shantakumar, Mary Beth Terry, Susan L. Teitelbaum, Alfred I. Neugut, Regina M. Santella, Jia Chen and Marilie D. Gammon

    Citation: BMC Cancer 2019 19:926

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  39. Content type: Case report

    Gingival metastasis from primary hepatocellular cancer (HCC) is rare, highly malignant, and generally has no distinct symptoms. Not performing a biopsy can lead to misdiagnosis. This article reports an 87-year...

    Authors: Yating Hou, Weiping Deng, Gang Deng, Linhui Hu, Chao Liu and Lishu Xu

    Citation: BMC Cancer 2019 19:925

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  40. Content type: Research article

    Current therapies fail to cure over a third of osteosarcoma patients and around three quarters of those with metastatic disease. “Smac mimetics” (also known as “IAP antagonists”) are a new class of anti-cancer...

    Authors: Tanmay M. Shekhar, Ingrid J. G. Burvenich, Michael A. Harris, Angela Rigopoulos, Damien Zanker, Alex Spurling, Belinda S. Parker, Carl R. Walkley, Andrew M. Scott and Christine J. Hawkins

    Citation: BMC Cancer 2019 19:924

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  41. Content type: Research article

    Glioblastoma (GB) is considered one of the most lethal tumors. Extensive research at the molecular level may enable to gain more profound insight into its biology and thus, facilitate development and testing o...

    Authors: Karolina Janik, Cezary Treda, Aneta Wlodarczyk, Joanna Peciak, Kamila Rosiak, Jolanta Zieba, Dagmara Grot, Adrianna Rutkowska, Roza Pawlowska, Waldemar Och, Piotr Rieske and Ewelina Stoczynska-Fidelus

    Citation: BMC Cancer 2019 19:923

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  42. Content type: Study protocol

    Pancreatic adenocarcinoma is a high-mortality neoplasm with a documented 5-years-overall survival around 5%. In the last decades, a real breakthrough in the treatment of the disease has not been achieved. Here...

    Authors: Viviana Vitolo, Lorenzo Cobianchi, Silvia Brugnatelli, Amelia Barcellini, Andrea Peloso, Angelica Facoetti, Alessandro Vanoli, Sara Delfanti, Lorenzo Preda, Silvia Molinelli, Catherine Klersy, Piero Fossati, Roberto Orecchia and Francesca Valvo

    Citation: BMC Cancer 2019 19:922

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  43. Content type: Research article

    Free flap-mediated gene therapy in the tumor bed following surgical resection is a promising approach in cancer targeted treatment of residual disease. We investigated the selective killing efficacy of a lenti...

    Authors: Jianhua Zhang, Yuanbo Liu, Mengqing Zang, Shan Zhu, Bo Chen, Shanshan Li, Bingjian Xue and Li Yan

    Citation: BMC Cancer 2019 19:921

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  44. Content type: Research article

    Tumor-infiltrating immune cells are present in various malignant tumors, but their clinical significance in gastric cancer (GC) remains unclear. This study aimed to investigate the prognostic significance of t...

    Authors: Jun Lu, Yu Xu, Yuan Wu, Xiao-yan Huang, Jian-wei Xie, Jia-bin Wang, Jian-xian Lin, Ping Li, Chao-hui Zheng, Ai-min Huang and Chang-ming Huang

    Citation: BMC Cancer 2019 19:920

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  45. Content type: Research article

    Single nucleotide polymorphisms (SNPs) in genes encoding mitotic kinases could influence development and progression of gastric cancer (GC).

    Authors: Aner Mesic, Marija Rogar, Petra Hudler, Nurija Bilalovic, Izet Eminovic and Radovan Komel

    Citation: BMC Cancer 2019 19:919

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  46. Content type: Research article

    A number of circular RNAs (circRNAs) have been identified in various cancer including F-box and WD repeat domain containing 7 (FBXW7) circular RNA (circ-FBXW7), which can suppress glioma cell growth. However, ...

    Authors: Haoran Lu, Baofu Yao, Xinyuan Wen and Baoqing Jia

    Citation: BMC Cancer 2019 19:918

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