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  1. Recent data have demonstrated that in locally advanced rectal cancer (LARC), a total neoadjuvant therapy (TNT) approach improves compliance with chemotherapy and increases rates of tumor response compared to n...

    Authors: Janet A. Alvarez, Qian Shi, Arvind Dasari, Julio Garcia-Aguilar, Hanna Sanoff, Thomas J. George, Theodore Hong, Greg Yothers, Philip Philip, Garth Nelson, Tareq Al Baghdadi, Olatunji B. Alese, Wini Zambare, Dana Omer, Floris S. Verheij, Aron Bercz…
    Citation: BMC Cancer 2024 24:901
    Content type: Study Protocol Published on:

  2. Leukemia is a type of blood cell cancer that is in the bone marrow’s blood-forming cells. Two types of Leukemia are acute and chronic; acute enhances fast and chronic growth gradually which are further classif...

    Authors: Sehar Ansar Khawaja, Muhammad Shoaib Farooq, Kashif Ishaq, Najah Alsubaie, Hanen Karamti, Elizabeth Caro Montero, Eduardo Silva Alvarado and Imran Ashraf
    Citation: BMC Cancer 2024 24:900
    Content type: Research Published on:

  3. This study aimed to evaluate the efficiency of hippocampal avoidance whole-brain radiotherapy with a simultaneous integrated boost (HA-WBRT-SIB) treating brain metastases (BM) and utility of the Hopkins Verbal...

    Authors: Zhuoran Li, Jianyang Wang, Lei Deng, Yirui Zhai, Tao Zhang, Nan Bi, Jingbo Wang, Xin Wang, Wenyang Liu, Zefen Xiao, Dongfu Chen, Jima Lv, Qinfu Feng, Wenqing Wang and Zongmei Zhou
    Citation: BMC Cancer 2024 24:899
    Content type: Research Published on:

  4. To provide reference for clinical development of ADCs in the industry, we analyzed the landscape and characteristics of clinical trials about antibody-drug conjugates (ADCs).

    Authors: Wenjing Zhou, Zhiyuan Xu, Shu Liu, Xiaohuan Lou, Pengcheng Liu, Huali Xie, Shuiyan Zhang, Xi Liu, Baoshan Zhuo and Hongbing Huang
    Citation: BMC Cancer 2024 24:898
    Content type: Research Published on:

  6. Indoleamine 2,3-dioxygenase 1 (IDO1) levels correlate with poor outcomes in urothelial carcinoma (UC). IDO1 and programmed death-ligand 1 (PD-L1) are often co-expressed. Epacadostat is a potent and highly sele...

    Authors: Irfan Cicin, Elizabeth R. Plimack, Howard Gurney, Raya Leibowitz, Boris Y. Alekseev, Francis X. Parnis, Avivit Peer, Andrea Necchi, Joaquim Bellmunt, Hiroyuki Nishiyama, Jason Clark, Mihaela Munteanu, Ritesh Kataria, Calvin Jia, Thomas Powles and Cora N. Sternberg
    Citation: BMC Cancer 2024 23(Suppl 1):1256
    Content type: Research Published on:

    This article is part of a Supplement: Volume 23 Supplement 1

  7. Advanced head and neck squamous cell carcinoma (HNSCC) has a poor prognosis, and new treatment options are needed. Combining immunotherapies with differing mechanisms of action may enhance clinical benefits co...

    Authors: Byoung Chul Cho, Irene Braña, Beatriz Cirauqui, Sercan Aksoy, Felix Couture, Ruey-Long Hong, Wilson H. Miller Jr, Manuel Chaves-Conde, Margarida Teixeira, Lance Leopold, Mihaela Munteanu, Joy Yang Ge, Ramona F. Swaby and Brett G. M. Hughes
    Citation: BMC Cancer 2024 23(Suppl 1):1254
    Content type: Research Published on:

    This article is part of a Supplement: Volume 23 Supplement 1

  8. Immunotherapy-based combinations have emerged as standard therapies for patients with metastatic renal cell carcinoma (mRCC). Pembrolizumab, a PD-1 inhibitor, combined with epacadostat, an indoleamine 2,3-deox...

    Authors: Primo N. Lara Jr, Luis Villanueva, Carolina Ibanez, Mustafa Erman, Jae Lyun Lee, Daniel Heinrich, Oleg Nikolaevich Lipatov, Craig Gedye, Erhan Gokmen, Alejandro Acevedo, Andrey Semenov, Se Hoon Park, Rustem Airatovich Gafanov, Fatih Kose, Mark Jones, Xiaoqi Du…
    Citation: BMC Cancer 2024 23(Suppl 1):1253
    Content type: Research Published on:

    This article is part of a Supplement: Volume 23 Supplement 1

  9. Indoleamine 2,3- dioxygenase 1 (IDO1) is an immunosuppressive enzyme that has been correlated with shorter disease-specific survival in patients with urothelial carcinoma (UC). IDO1 may counteract the antitumo...

    Authors: Andrea Necchi, Michiel S. Van der Heijden, Dmytro Trukhin, Avivit Peer, Howard Gurney, Boris Y. Alekseev, Francis X. Parnis, Raya Leibowitz, Maria De Santis, Petros Grivas, Jason Clark, Mihaela Munteanu, Ritesh Kataria, Calvin Jia, Arjun V. Balar and Ronald de Wit
    Citation: BMC Cancer 2024 23(Suppl 1):1252
    Content type: Research Published on:

    This article is part of a Supplement: Volume 23 Supplement 1

  10. Pembrolizumab is a first-line therapy for certain patients with advanced/metastatic non-small cell lung cancer (NSCLC). Combining pembrolizumab with other immunotherapies may enhance tumor cell killing and cli...

    Authors: Takaaki Tokito, Oleksii Kolesnik, Jens Sørensen, Mehmet Artac, Martín Lázaro Quintela, Jong-Seok Lee, Maen Hussein, Miklos Pless, Luis Paz-Ares, Lance Leopold, Jeannie Daniel, Mihaela Munteanu, Ayman Samkari, Lu Xu and Charles Butts
    Citation: BMC Cancer 2024 23(Suppl 1):1251
    Content type: Research Published on:

    This article is part of a Supplement: Volume 23 Supplement 1

  11. The combination of the checkpoint inhibitor (CPI) pembrolizumab and platinum-based chemotherapy is effective frontline therapy for advanced non-small cell lung cancer (NSCLC) lacking targetable mutations. Indo...

    Authors: Michael Boyer, Rina Hui, Damien Urban, Philip Clingan, Wu-Chou Su, Celine Devaux, Shirish Gadgeel, Marina Garassino, Lance Leopold, Jeannie Daniel, Mihaela C. Munteanu, Ayman Samkari, Yiwen Luo and Delvys Rodriguez Abreu
    Citation: BMC Cancer 2024 23(Suppl 1):1250
    Content type: Research Published on:

    This article is part of a Supplement: Volume 23 Supplement 1

  12. Cervical cancer has extremely high morbidity and mortality, and its pathogenesis is still in the exploratory stage. This study aimed to screen and identify differentially expressed genes (DEGs) related to cerv...

    Authors: Xinmeng Yang, Mengsi Zhou, Yingying Luan, Kanghua Li, Yafen Wang and Xiaofeng Yang
    Citation: BMC Cancer 2024 24:897
    Content type: Research Published on:

  13. Dysphagia is common in individuals who have undergone posterior fossa tumor (PFT) resection and negatively impacts on the individual’s quality of life, nutritional status, and overall health. We aimed to quant...

    Authors: Yuyu Duan, Yueli Wang, Xiaowei Zhang, Jingjuan Huang, Zhihuan Zhou and Qinqin Zhao
    Citation: BMC Cancer 2024 24:896
    Content type: Research Published on:

  14. The metabolic tumour area (MTA) was found to be a promising predictor of prostate cancer. However, the role of MTA based on 18F-FDG PET/CT in diffuse large B-cell lymphoma (DLBCL) prognosis remains unclear. This ...

    Authors: Silu Cui, Wenchong Xin, Fei Wang, Xiaoliang Shao, Xiaonan Shao, Rong Niu, Feifei Zhang, Yunmei Shi, Bao Liu, Weiying Gu and Yuetao Wang
    Citation: BMC Cancer 2024 24:895
    Content type: Research Published on:

  15. Leukemia, a type of blood cell cancer, is categorized by the type of white blood cells affected (lymphocytes or myeloid cells) and disease progression (acute or chronic). In 2020, it ranked 15th among the most...

    Authors: Alireza Zangooie, Shima Tavoosi, Mahan Arabhosseini, Aram Halimi, Helia Zangooie, Amir Hossein Baghsheikhi, Soheila Rahgozar, Mohammad Ahmadvand, Alireza Mosavi Jarrahi and Zahra Salehi
    Citation: BMC Cancer 2024 24:894
    Content type: Systematic Review Published on:

  17. In people with prediabetes, the link between developing type 2 diabetes (T2D) and cancer risk among those with impaired glucose tolerance (IGT) remains uncertain. We examined this association in IGT individual...

    Authors: Zheng Wang, Dahai Yu, Uchechukwu Levi Osuagwu, Karen Pickering, John Baker, Richard Cutfield, Yamei Cai, Brandon J. Orr-Walker, Gerhard Sundborn, Bingjie Qu, Zhanzheng Zhao and David Simmons
    Citation: BMC Cancer 2024 24:892
    Content type: Research Published on:

  18. After radical cystectomy physical activity is important to reduce risk of complications, but patients with urinary bladder cancer have difficulties in achieving general recommendations on physical activity and...

    Authors: Andrea Porserud, Patrik Karlsson, Markus Aly, Elisabeth Rydwik, Simon Torikka, Lars Henningsohn, Malin Nygren-Bonnier and Maria Hagströmer
    Citation: BMC Cancer 2024 24:891
    Content type: Research Published on:

  19. The therapeutic method for many malignant and non-malignant diseases is hematopoietic stem cell transplantation (HSCT), but it is not always fully successful in all patients. Indeed, HSCT can be influenced by ...

    Authors: Negar Habibollahzadeh, Samin Yavari, Yasin Mirazimi, Amir Hossein Aghayan, Atefeh Davoudian and Mohammad Rafiee
    Citation: BMC Cancer 2024 24:890
    Content type: Systematic Review Published on:

  20. Glioblastoma is an aggressive brain cancer, usually of unknown etiology, and with a very poor prognosis. Survival from diagnosis averages only 3 months if left untreated and this only increases to 12–15 months...

    Authors: Michael J. Bickerdike, Imane Nafia, Alban Bessede, Cheng-Bang Chen and Medhi Wangpaichitr
    Citation: BMC Cancer 2024 24:889
    Content type: Research Published on:

  21. Respiratory failure, intracranial hemorrhage and infection were more common in hyperleukocytic acute myeloid leukemia patients than in non-hyperleukocytic leukemia patients. Compared with non-apheresis treatme...

    Authors: Ruiyang Pan, Anjie Xu, Li Liu, Jinxian Wu, Xinqi Li, Guopeng Chen, Ruihang Li, Wanyue Yin, Dandan Liu, Xiaoyan Liu and Fuling Zhou
    Citation: BMC Cancer 2024 24:888
    Content type: Research Published on:

  22. In the pivotal phase III RECOURSE trial, trifluridine/tipiracil (FTD/TPI) improved progression-free and overall survival (PFS, OS) of patients with pre-treated metastatic colorectal cancer (mCRC). Subsequently...

    Authors: Meinolf Karthaus, Volker Heinemann, Jorge Riera-Knorrenschild, Albrecht Kretzschmar, Manfred Welslau, Ulrich Kaiser, Henning Pelz, Thomas J. Ettrich, Swantje Held, Linde Kehmann, Jürgen Hess, Timo Reisländer and Lena Weiss
    Citation: BMC Cancer 2024 24:887
    Content type: Research Published on:

  23. Mucosa melanoma is a rare condition with aggressive behavior and a less favorable prognosis compared to cutaneous melanoma. The objective of this study was to estimate the overall survival and clinical outcome...

    Authors: Ana M. García, Luis G. Parra-Lara, Diana M. Mendoza-Urbano, Juan C. Bravo and Ángela Zambrano Harvey
    Citation: BMC Cancer 2024 24:886
    Content type: Research Published on:

  24. Glutathione S-transferase theta 1 (GSTT1) enzyme plays a key role in the neutralization of electrophilic compounds such as carcinogens. Herein, we aimed to evaluate GSTT1 deletion polymorphism and susceptibility ...

    Authors: Sepehr Sadafi, Parsia Choubsaz, Seyed Mohammad Mohyeddin Kazemeini, Mohammad Moslem Imani and Masoud Sadeghi
    Citation: BMC Cancer 2024 24:885
    Content type: Research Published on:

  25. Cancer stage at diagnosis is an important prognostic indicator for patient outcomes, with detection at later stages associated with increased mortality and morbidity. The impact of cancer stage on patient-repo...

    Authors: Karen C. Chung, Anushini Muthutantri, Grace G. Goldsmith, Megan R. Watts, Audrey E. Brown and Donald L. Patrick
    Citation: BMC Cancer 2024 24:884
    Content type: Research Published on:

  26. The role of miR-145-5p in non-small cell lung cancer (NSCLC) has been studied, however, the regulation of hBMSCs-derived exosomes (Exo) transmitted miR-145-5p in NSCLC was still unknown. This study aimed to in...

    Authors: Wu Yan, Haiyu Yang, Dekun Duan, Yufeng Wu, Youhu Liu, Jianping Mao, Yong Zhao and Junsong Ye
    Citation: BMC Cancer 2024 24:883
    Content type: Research Published on:

  27. Indigenous peoples worldwide experience inequitable cancer outcomes, and it is unclear if this is underpinned by differences in or inadequate use of endocrine treatment (ET), often used in conjunction with oth...

    Authors: Habtamu Mellie Bizuayehu, Sewunet Admasu Belachew, Shafkat Jahan, Abbey Diaz, Siddhartha Baxi, Kalinda Griffiths and Gail Garvey
    Citation: BMC Cancer 2024 24:882
    Content type: Systematic Review Published on:

  28. In this article, we read with great attention the correspondence by Bullement et al., regarding our published study on cost-effectiveness of first-line immunotherapy combinations with or without chemotherapy f...

    Authors: Wen Hui, Zhixiang Gao, Min Zhu, Huazhang Wu and Yuanyi Cai
    Citation: BMC Cancer 2024 24:881
    Content type: Matters arising Published on:

    The original article was published in BMC Cancer 2024 24:879

  29. Bladder cancer (BLCA) poses a significant global health challenge due to its high incidence, poor prognosis, and limited treatment options.

    Authors: Muhammad Sarfaraz Iqbal, Nimra Sardar, Kaoqing Peng, Layla A. Almutairi, Xialo Duan, Fouzia Tanvir, Kotb A. Attia, Gouhua Zeng and Di Gu
    Citation: BMC Cancer 2024 24:880
    Content type: Research Published on:

  31. Oxaliplatin-containing adjuvant chemotherapy yields a significant survival benefit in stage III colon cancer and is the standard of care. Simultaneously, it causes dose-dependent peripheral neuropathy that may...

    Authors: Colin Sue-Chue-Lam, Christine Brezden-Masley, Rinku Sutradhar, Amy Ying Xin Yu and Nancy Noel Baxter
    Citation: BMC Cancer 2024 24:878
    Content type: Research Published on:

  32. Inetetamab is the first domestically developed innovative anti-HER2 monoclonal antibody in China, proven effective and safe in HER2-positive advanced breast cancer. However, its efficacy and safety in neoadjuv...

    Authors: Mingxia Jiang, Yue Chai, Jiaxuan Liu, Maiyue He, Yipeng Wang, Xue Yang, Zeyu Xing, Mengqi Zhang, Shihan Zhou, Fei Ma, Jiayu Wang, Peng Yuan, Binghe Xu and Qiao Li
    Citation: BMC Cancer 2024 24:877
    Content type: Research Published on:

  33. Carboplatin and paclitaxel (CP) have been the standard of care for advanced/recurrent endometrial cancer (EC) for many years. However, this chemotherapy combination shows limited efficacy and recurrences often...

    Authors: Alexandra Leary, Purificación Estévez-García, Renaud Sabatier, Isabelle Ray-Coquard, Margarita Romeo, Pilar Barretina-Ginesta, Marta Gil-Martin, Elena Garralda, Joaquim Bosch-Barrera, Teresa Morán, Paloma Martin-Martorell, Ernest Nadal, Pere Gascón, Jordi Rodon, Jose M Lizcano, Pau Muñoz-Guardiola…
    Citation: BMC Cancer 2024 24:876
    Content type: Research Published on:

  34. The diagnosis of solitary pulmonary nodules has always been a difficult and important point in clinical research, especially granulomatous nodules (GNs) with lobulation and spiculation signs, which are easily ...

    Authors: Yanhua Wen, Wensheng Wu, Yuling Liufu, Xiaohuan Pan, Yingying Zhang, Shouliang Qi and Yubao Guan
    Citation: BMC Cancer 2024 24:875
    Content type: Research Published on:

  35. For patients with rectal cancer, the utilization of temporary ileostomy (TI) has proven effective in minimizing the occurrence of severe complications post-surgery, such as anastomotic leaks; however, some pat...

    Authors: Chenglin Tang, Fan He, Fuyu Yang, Defei Chen, Junjie Xiong, Yu Zou and Kun Qian
    Citation: BMC Cancer 2024 24:874
    Content type: Research Published on:

  36. In older patients, esophageal squamous cell carcinoma (ESCC) is difficult to treat using standard therapies, including surgery and cisplatin-based chemoradiotherapy. Paclitaxel (PTX) has radiosensitizing activ...

    Authors: Kenro Hirata, Kayo Yoshida, Chikatoshi Katada, Akinori Watanabe, Takahiro Tsushima, Toshifumi Yamaguchi, Sachiko Yamamoto, Hideki Ishikawa, Yasunori Sato, Chiyo K. Imamura, Yusuke Tanigawara, Yoshinori Ito, Ken Kato, Yuko Kitagawa and Yasuo Hamamoto
    Citation: BMC Cancer 2024 24:873
    Content type: Research Published on:

  37. The aim of this study was to assess the risk factors for anastomotic stricture in esophageal cancer patients undergoing esophagectomy. Esophageal anastomotic stricture is the most common long-term complication...

    Authors: Yuan Zhong, Ruijuan Sun, Wei Li, Weiqian Wang, Jianpeng Che, Linlin Ji, Bingrong Guo and Chunbo Zhai
    Citation: BMC Cancer 2024 24:872
    Content type: Systematic Review Published on:

  38. The management of locally recurrent gynecological carcinoma remains a challenge due to the limited availability of data. This study aims to share our institutional experience in using definitive radiotherapy (...

    Authors: Hui Cong, Xiaojing Yang, Zhaobin Li, Zhen Li, Shuchen Lin, Wei Jiang and Jie Fu
    Citation: BMC Cancer 2024 24:871
    Content type: Research Published on:

  40. CD8+T cells secreting granzyme A (GZMA) can induce pyroptosis in tumor cells by effectively cleaving gasdermin B (GSDMB), which is stimulated by interferon-γ (IFN-γ). However, the interaction between GZMA-express...

    Authors: Jiayi Yang, Xinyi Ding, Zhang Fang, Shaoxian Wu, Maoling Yuan, Rongzhang Chen, Qinlan Xu, Xinran Gao, Haoyu Wu, Lujun Chen, Xiao Zheng and Jingting Jiang
    Citation: BMC Cancer 2024 24:869
    Content type: Research Published on:

  41. Cancer is a predominant cause of death globally. PHD-finger domain protein 5 A (PHF5A) has been reported to participate in various cancers; however, there has been no pan-cancer analysis of PHF5A. This study a...

    Authors: Qianqian Cheng, Wenbin Ji, Zhenyu Lv, Wei Wang, Zhaiyue Xu, Shaohua Chen, Wenting Zhang, Yu Shao, Jing Liu and Yan Yang
    Citation: BMC Cancer 2024 24:868
    Content type: Research Published on:

  42. To evaluate the safety and efficacy of the granisetron transdermal delivery system (GTDS) combined with Dexamethasone for preventing chemotherapy-induced nausea and vomiting (CINV) in patients receiving Capeci...

    Authors: Cong Wang, Zhansheng Jiang, Jie Zhang, Yan Zhuang, Lining Sun, Jing Zhang, Manman Quan, Lan Lan, Yanwei Li, Bin Wang, Zhanyu Pan and Zhuchen Yan
    Citation: BMC Cancer 2024 24:867
    Content type: Research Published on:

  43. The identification of viable tumors and radiation necrosis after stereotactic radiosurgery (SRS) is crucial for patient management. Tumor habitat analysis involving the grouping of similar voxels can identify ...

    Authors: Yun Hwa Roh, Ji Eun Park, Seo Young Park, Young Hyun Cho, Young-Hoon Kim, Sang Woo Song, Shinkyo Yoon and Ho Sung Kim
    Citation: BMC Cancer 2024 24:866
    Content type: Study Protocol Published on:

  44. Authors: Paul Nankivell, Piers Gaunt, Claire Gaunt, Julia Sissons, Evaggelia Liaskou, Yolande Jefferson, Tessa Fulton-Lieuw, Saloni Mittal and Hisham Mehanna
    Citation: BMC Cancer 2024 24:861
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2024 24:823

  45. Adverse reactions are prone to occur in the early stage of chemotherapy and can negatively affect the dietary intake and nutritional status of breast cancer (BC) patients. Consequently, they need to participat...

    Authors: Han Tang, Wei Zhang, Haiyan Shen, Haili Tang, Min Cai, Tao Wang, Pei Yan, Liang Li, Yan Wang, Huadong Zhao and Lei Shang
    Citation: BMC Cancer 2024 24:859
    Content type: Study Protocol Published on:

  46. Colon cancer remains a major health concern worldwide, with genetic factors playing a crucial role in its development. Toll-like receptors (TLRs) has been implicated in various cancers, but their role in colon...

    Authors: Ang Li, Hui Gao, Hongjiao Wu, Yuning Xie, Zhenxian Jia, Zhenbang Yang, Zhi Zhang and Xuemei Zhang
    Citation: BMC Cancer 2024 24:858
    Content type: Research Published on:

  47. Residual fibroglandular breast tissue (RFGT) following a mastectomy is associated with the remaining of occult breast cancer at the time of mastectomy as well as an increased local recurrence risk thereafter. ...

    Authors: Deutschmann Christine, Singer F. Christian, Korbatits Ricarda, Kraus Christine, Gschwantler-Kaulich Daphne, Leser Carmen, Marzogi Alaa, Pascal A.T. Baltzer, Helbich H. Thomas, Pfeiler Georg and Clauser Paola
    Citation: BMC Cancer 2024 24:856
    Content type: Research Published on:

  48. Retroperitoneal liposarcoma (RLPS) constitutes the majority of retroperitoneal sarcomas. While surgical resection remains the sole curative approach, determining the optimal surgical strategy for RLPS remains ...

    Authors: Dao-Ning Liu, Liang Yan, Zhong-Wu Li, Hai-Yue Wang, Xiu-Yun Tian, Ang Lv and Chun-Yi Hao
    Citation: BMC Cancer 2024 24:855
    Content type: Research Published on:

  49. Metabolic dysregulation is recognized as a significant hallmark of cancer progression. Although numerous studies have linked specific metabolic pathways to cancer incidence, the causal relationship between blo...

    Authors: Gujie Wu, Jun Liu, Haochun Shi, Binyang Pan, Min Li, Xiaolin Wang, Yao Li, Lin Cheng, Weigang Guo and Yiwei Huang
    Citation: BMC Cancer 2024 24:854
    Content type: Research Published on:

  50. Immune checkpoint inhibitors, such as anti-programmed cell death-1 (PD-1) and PD-1 ligand-1 (PD-L1) antibodies, have achieved breakthrough results in improving long-term survival rates in lung cancer. Although...

    Authors: Yun Wang, Rujia Chen, Zhenzhou Guo, Wei Wei, Ting Wang, Renren Ouyang, Xu Yuan, Yutong Xing, Feng Wang, Shiji Wu and Hongyan Hou
    Citation: BMC Cancer 2024 24:851
    Content type: Research Published on:

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