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  1. Study protocol

    Randomized study comparing full dose monotherapy (S-1 followed by irinotecan) and reduced dose combination therapy (S-1/oxaliplatin followed by S-1/irinotecan) as initial therapy for older patients with metastatic colorectal cancer: NORDIC 9

    Metastatic colorectal cancer (mCRC) is a disease of older age, but there is a relative lack of knowledge about effects of chemotherapy in older patients as they are under-represented in clinical trials. Little...

    Stine Braendegaard Winther, Pia Österlund, Åke Berglund, Bengt Glimelius, Camilla Qvortrup, Halfdan Sorbye and Per Pfeiffer

    BMC Cancer 2017 17:548

    Published on: 16 August 2017

  2. Study protocol

    Impact of new generation hormone-therapy on cognitive function in elderly patients treated for a metastatic prostate cancer: Cog-Pro trial protocol

    New generation hormone-therapies (NGHT) targeting the androgen signalling pathway are nowadays proposed to elderly patients with metastatic castration-resistant prostate cancer (CRPCa). The impact of these tre...

    Marie Lange, Heidi Laviec, Hélène Castel, Natacha Heutte, Alexandra Leconte, Isabelle Léger, Bénédicte Giffard, Aurélie Capel, Martine Dubois, Bénédicte Clarisse, Elodie Coquan, Frédéric Di Fiore, Sophie Gouérant, Philippe Bartélémy, Laure Pierard, Karim Fizazi…

    BMC Cancer 2017 17:549

    Published on: 16 August 2017

  3. Research article

    Phase I dose-escalation study of pazopanib combined with bevacizumab in patients with metastatic renal cell carcinoma or other advanced tumors

    Vascular endothelial growth factor (VEGF) directed therapies are being used in a large number of advanced tumors. Metastatic renal cell carcinoma (mRCC) is highly dependent on the VEGF pathway; VEGF receptor (...

    Sylvie Négrier, David Pérol, Rastislav Bahleda, Antoine Hollebecque, Etienne Chatelut, Helen Boyle, Philippe Cassier, Séverine Metzger, Ellen Blanc, Jean-Charles Soria and Bernard Escudier

    BMC Cancer 2017 17:547

    Published on: 15 August 2017

  4. Research article

    Prognostic value of pretreatment serum alanine aminotransferase/aspartate aminotransferase (ALT/AST) ratio and gamma glutamyltransferase (GGT) in patients with esophageal squamous cell carcinoma

    The levels of liver function tests (LFTs) are often used to assess liver injury and non-liver disease-related mortality. In our study, the relationship between pretreatment serum LFTs and overall survival (OS)...

    Hao Huang, Xue-Ping Wang, Xiao-Hui Li, Hao Chen, Xin Zheng, Jian-Hua Lin, Ting Kang, Lin Zhang and Pei-Song Chen

    BMC Cancer 2017 17:544

    Published on: 14 August 2017

  5. Research article

    Tumor microenvironment conditions alter Akt and Na+/H+ exchanger NHE1 expression in endothelial cells more than hypoxia alone: implications for endothelial cell function in cancer

    Chronic angiogenesis is a hallmark of most tumors and takes place in a hostile tumor microenvironment (TME) characterized by hypoxia, low nutrient and glucose levels, elevated lactate and low pH. Despite this,...

    A. K. Pedersen, J. Mendes Lopes de Melo, N. Mørup, K. Tritsaris and S. F. Pedersen

    BMC Cancer 2017 17:542

    Published on: 14 August 2017

  6. Research article

    Reducing the socioeconomic gradient in uptake of the NHS bowel cancer screening Programme using a simplified supplementary information leaflet: a cluster-randomised trial

    Uptake of colorectal cancer screening is low in the English NHS Bowel Cancer Screening Programme (BCSP). Participation in screening is strongly associated with socioeconomic status. The aim of this study was t...

    Samuel G. Smith, Jane Wardle, Wendy Atkin, Rosalind Raine, Lesley M. McGregor, Gemma Vart, Steve Morris, Stephen W. Duffy, Susan Moss, Allan Hackshaw, Stephen Halloran, Ines Kralj-Hans, Rosemary Howe, Julia Snowball, Graham Handley, Richard F. Logan…

    BMC Cancer 2017 17:543

    Published on: 14 August 2017

  7. Research article

    Endogenous controls of gene expression in N-methyl-N-nitrosourea-induced T-cell lymphoma in p53-deficient mice

    Real-time polymerase chain reaction (PCR) has become an increasingly important technique for gene expression profiling because it can provide insights into complex biological and pathological processes and be ...

    Xi Wu, Susu Liu, Jianjun Lyu, Shuya Zhou, Yanwei Yang, Chenfei Wang, Wenda Gu, Qin Zuo, Baowen Li and Changfa Fan

    BMC Cancer 2017 17:545

    Published on: 14 August 2017

  8. Research article

    A type I combi-targeting approach for the design of molecules with enhanced potency against BRCA1/2 mutant- and O6-methylguanine-DNA methyltransferase (mgmt)- expressing tumour cells

    Mutations of the DNA repair proteins BRCA1/2 are synthetically lethal with the DNA repair enzyme poly(ADP-ribose) polymerase (PARP), which when inhibited, leads to cell death due to the absence of compensatory...

    Zhor Senhaji Mouhri, Elliot Goodfellow and Bertrand Jean-Claude

    BMC Cancer 2017 17:540

    Published on: 11 August 2017

  9. Research article

    Angiopoietin-1 deficiency increases tumor metastasis in mice

    Angipoietin-1 activation of the tyrosine kinase receptor Tek expressed mainly on endothelial cells leads to survival and stabilization of endothelial cells. Studies have shown that Angiopoietin-1 counteracts p...

    Iacovos P. Michael, Martina Orebrand, Marta Lima, Beatriz Pereira, Olga Volpert, Susan E. Quaggin and Marie Jeansson

    BMC Cancer 2017 17:539

    Published on: 11 August 2017

  10. Research article

    Prognostic significance of BRAF and NRAS mutations in melanoma: a German study from routine care

    Hotspot mutations of the oncogenes BRAF and NRAS are the most common genetic alterations in cutaneous melanoma. Specific inhibitors of BRAF and MEK have shown significant survival benefits in large phase III t...

    Markus V. Heppt, Timo Siepmann, Jutta Engel, Gabriele Schubert-Fritschle, Renate Eckel, Laura Mirlach, Thomas Kirchner, Andreas Jung, Anja Gesierich, Thomas Ruzicka, Michael J. Flaig and Carola Berking

    BMC Cancer 2017 17:536

    Published on: 10 August 2017

  11. Research article

    Oncological outcomes in an Australian cohort according to the new prostate cancer grading groupings

    A new 5-tiered grading grouping system has recently been endorsed for reporting of prostate cancer (PCa) grade to better reflect escalating risk of progression and cancer death. While several validations of th...

    K. R. Beckmann, A. D. Vincent, M. E. O’Callaghan, P. Cohen, S. Chang, M. Borg, S. M. Evans, D. M. Roder and K. L. Moretti

    BMC Cancer 2017 17:537

    Published on: 10 August 2017

  12. Research article

    Precision medicine approaches to lung adenocarcinoma with concomitant MET and HER2 amplification

    Patient-derived xenograft (PDX) models are important tools in precision medicine and for the development of targeted therapies to treat cancer patients. This study aimed to evaluate our precision medicine stra...

    Doo-Yi Oh, Kyungsoo Jung, Ji-Young Song, Seokhwi Kim, Sang Shin, Yong-Jun Kwon, Ensel Oh, Woong-Yang Park, Sang Yong Song and Yoon-La Choi

    BMC Cancer 2017 17:535

    Published on: 10 August 2017

  13. Research article

    A lowered 26S proteasome activity correlates with mantle lymphoma cell lines resistance to genotoxic stress

    Mantle cell lymphoma (MCL) is a B-cell hemopathy characterized by the t(11;14) translocation and the aberrant overexpression of cyclin D1. This results in an unrestrained cell proliferation. Other genetic alte...

    Khaoula Ben Younes, Simon Body, Élodie Costé, Pierre-Julien Viailly, Hadjer Miloudi, Clémence Coudre, Fabrice Jardin, Fatma Ben Aissa-Fennira and Brigitte Sola

    BMC Cancer 2017 17:538

    Published on: 10 August 2017

  14. Research article

    An analysis of 97 previously diagnosed de novo adult acute erythroid leukemia patients following the 2016 revision to World Health Organization classification

    The incidence of acute erythroid leukemia subtype (AEL) is rare, accounting for 5% of cases of acute myeloid leukemia (AML), and the outcome is dismal. However, in 2016 revision to the WHO classification, the ...

    Shaowei Qiu, Erlie Jiang, Hui Wei, Dong Lin, Guangji Zhang, Shuning Wei, Chunlin Zhou, Kaiqi Liu, Ying Wang, Bingcheng Liu, Yuntao Liu, Benfa Gong, Xiaoyuan Gong, Sizhou Feng, Yingchang Mi, Mingzhe Han…

    BMC Cancer 2017 17:534

    Published on: 9 August 2017

  15. Research article

    The cost-effectiveness of active surveillance compared to watchful waiting and radical prostatectomy for low risk localised prostate cancer

    Radical prostatectomy is the most common treatment for localised prostate cancer in New Zealand. Active surveillance was introduced to prevent overtreatment and reduce costs while preserving the option of radi...

    Chunhuan Lao, Richard Edlin, Paul Rouse, Charis Brown, Michael Holmes, Peter Gilling and Ross Lawrenson

    BMC Cancer 2017 17:529

    Published on: 8 August 2017

  16. Research article

    Hedgehog inhibitor sonidegib potentiates 177Lu-octreotate therapy of GOT1 human small intestine neuroendocrine tumors in nude mice

    177Lu-octreotate can be used to treat somatostatin receptor expressing neuroendocrine tumors. It is highly effective in animal models, but clinical studies have so far only demonstrate...

    Johan Spetz, Britta Langen, Nils Rudqvist, Toshima Z. Parris, Khalil Helou, Ola Nilsson and Eva Forssell-Aronsson

    BMC Cancer 2017 17:528

    Published on: 8 August 2017

  17. Research article

    Squamous differentiation in patients with superficial bladder urothelial carcinoma is associated with high risk of recurrence and poor survival

    The independent prognostic role of squamous differentiation in pT1 bladder urothelial carcinoma has not been reported in previous studies. This article describes the impact of squamous differentiation on tumor...

    Gang Li, Jianpeng Yu, Hualin Song, Shimiao Zhu, Libin Sun, Zhiqun Shang and Yuanjie Niu

    BMC Cancer 2017 17:530

    Published on: 8 August 2017

  18. Research article

    High prevalence of co-infection between human papillomavirus (HPV) 51 and 52 in Mexican population

    Human papillomavirus (HPV) is associated with the genesis of cervical carcinoma. The co-infection among HPV genotypes is frequent, but the clinical significance is controversial; in Mexico, the prevalence and ...

    Jazbet Gallegos-Bolaños, Jessica Alejandra Rivera-Domínguez, José Miguel Presno-Bernal and Rodolfo Daniel Cervantes-Villagrana

    BMC Cancer 2017 17:531

    Published on: 8 August 2017

  19. Research article

    Levels of activated platelet-derived microvesicles in patients with soft tissue sarcoma correlate with an increased risk of venous thromboembolism

    Microvesicles are small vesicles expressing specific antigens from their cells of origin. Elevated levels of microvesicles have been shown to be associated with coagulation disorders as well as with different ...

    A. Fricke, P. V. Ullrich, A. F. V. Cimniak, C. Becherer, M. Follo, J. Heinz, J. Scholber, G. W. Herget, O. Hauschild, U. A. Wittel, G. B. Stark, H. Bannasch, D. Braig and S. U. Eisenhardt

    BMC Cancer 2017 17:527

    Published on: 7 August 2017

  20. Research article

    A pilot evaluation of magnetic resonance imaging characteristics seen with solid papillary carcinomas of the breast in 4 patients

    Solid papillary carcinoma (SPC) is a rare variant of breast papillary carcinoma with unique pathological morphology and biological behavior. There is only one case report on T1-MRI of SPC. In this study, we repor...

    Lina Zhang, Ling Zhuang, Chang Shi, Yanwei Miao, Weisheng Zhang, Qingwei Song, Jianyun Kang, Zhijin Lang, Xuegang Xin, Ailian Liu and Jiani Hu

    BMC Cancer 2017 17:525

    Published on: 7 August 2017

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