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  1. Content type: Correction

    Following publication of the original article [1], it was reported that the legend for Fig. 1 was incomplete. The complete figure legend is:

    Authors: Aleksandar Sekulic, Michael R. Migden, Nicole Basset-Seguin, Claus Garbe, Anja Gesierich, Christopher D. Lao, Chris Miller, Laurent Mortier, Dedee F. Murrell, Omid Hamid, Jorge F. Quevedo, Jeannie Hou, Edward McKenna, Natalie Dimier, Sarah Williams, Dirk Schadendorf…

    Citation: BMC Cancer 2019 19:366

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    The original article was published in BMC Cancer 2017 17:332

  2. Content type: Research article

    Worldwide, breast cancer is the main cause of cancer mortality in women. Most cases originate in mammary ductal cells that produce the nipple aspirate fluid (NAF). In cancer patients, this secretome contains p...

    Authors: Giselle Villa Flor Brunoro, Paulo Costa Carvalho, Valmir C. Barbosa, Dante Pagnoncelli, Claudia Vitória De Moura Gallo, Jonas Perales, René Peiman Zahedi, Richard Hemmi Valente and Ana Gisele da Costa Neves-Ferreira

    Citation: BMC Cancer 2019 19:365

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  3. Content type: Research article

    Our aim of the study is to investigate the feasibility of preoperative prediction for hepatocellular carcinoma (HCC) histological grading using gadoxetic acid-enhanced magnetic resonance imaging (MRI).

    Authors: Kun Huang, Zhi Dong, Huasong Cai, Mengqi Huang, Zhenpeng Peng, Ling Xu, Yingmei Jia, Chenyu Song, Zi-Ping Li and Shi-Ting Feng

    Citation: BMC Cancer 2019 19:364

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  4. Content type: Research article

    Hepatoma arterial-embolization prognostic (HAP) score and its modifications (modified HAP [mHAP] and mHAP-II), consisting of some or all of the following factors of tumor size, number, alpha-fetoprotein, bilir...

    Authors: Yehyun Park, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Jong Eun Yeon, Kwan Soo Byun, Hye Soo Kim, Ji Hoon Kim and Seung Up Kim

    Citation: BMC Cancer 2019 19:363

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  5. Content type: Research article

    Phase I trials aim to identify the recommended dose for further development. Health-related quality of life (HRQoL) could be a complement to the usual National Cancer Institute Common Terminology Criteria for ...

    Authors: Frédéric Fiteni, Isabelle Le Ray, Ahmad Ousmen, Nicolas Isambert, Amélie Anota and Franck Bonnetain

    Citation: BMC Cancer 2019 19:361

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  6. Content type: Research article

    In clinical practice, the detection of biomarkers is mostly based on primary tumors for its convenience in acquisition. However, immune checkpoints may express differently between primary and metastatic tumor....

    Authors: Xingming Zhang, Xiaoxue Yin, Haoran Zhang, Guangxi Sun, Yaojing Yang, Junru Chen, Xudong Zhu, Peng Zhao, Jinge Zhao, Jiandong Liu, Ni Chen, Jia Wang, Pengfei Shen and Hao Zeng

    Citation: BMC Cancer 2019 19:360

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  7. Content type: Research article

    Micafungin is a well-tolerated and effective prophylactic antifungal agent used in hematologic diseases. In this prospective trial, we evaluated the efficacy and safety of prophylactic micafungin during first ...

    Authors: Hyunkyung Park, Jeonghwan Youk, Dong-Yeop Shin, Junshik Hong, Inho Kim, Nam Joong Kim, Jeong-Ok Lee, Soo-Mee Bang, Sung-Soo Yoon, Wan Beom Park and Youngil Koh

    Citation: BMC Cancer 2019 19:358

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  8. Content type: Research article

    Osteosarcoma is the most common malignant bone tumor in children. Survival remains poor among histologically poor responders, and there is a need to identify them at diagnosis to avoid delivering ineffective t...

    Authors: Krithika Bhuvaneshwar, Michael Harris, Yuriy Gusev, Subha Madhavan, Ramaswamy Iyer, Thierry Vilboux, John Deeken, Elizabeth Yang and Sadhna Shankar

    Citation: BMC Cancer 2019 19:357

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  9. Content type: Research article

    Glucocorticoid receptor (GR) activation has been associated with breast cancer cell survival in vitro. Glucocorticoid (GC)-dependent protection against tumor necrosis factor (TNF)-induced cell death has been w...

    Authors: Irma B. Mitre-Aguilar, Tonatiuh Barrios-Garcia, Victor M. Ruiz-Lopez, Alberto J. Cabrera-Quintero, Nancy R. Mejia-Dominguez, Jose L. Ventura-Gallegos, Daniel Moreno-Mitre, Alejandro Aranda-Gutierrez, Janini Mejia-Rangel, Alma R. Escalona-Guzman, Yanin Chavarri-Guerra, Alfonso Leon-Del-Rio and Alejandro Zentella-Dehesa

    Citation: BMC Cancer 2019 19:356

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  10. Content type: Case report

    Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) that often affects men over the age of 60. Systemic metastasis of MCL to eyes is rare and intraocular involvement is even rare...

    Authors: Minghang Pei, Chan Zhao, Fei Gao and Meifen Zhang

    Citation: BMC Cancer 2019 19:355

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  11. Content type: Research article

    Head and neck squamous cell carcinoma (HNSCC) represents one of the most common malignancies worldwide with a high mortality rate mainly due to lack of early detection markers, frequent association with metast...

    Authors: Subhayan Sur, Hiroshi Nakanishi, Robert Steele and Ratna B. Ray

    Citation: BMC Cancer 2019 19:354

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  12. Content type: Research article

    Locally advanced or metastatic non-small cell lung cancer (NSCLC) that has progressed after first-line treatment has a poor prognosis. Recent randomized clinical trials (RCTs) have demonstrated survival benefi...

    Authors: Adrian D. Vickers, Katherine B. Winfree, Gebra Cuyun Carter, Urpo Kiiskinen, Min-Hua Jen, Donald Stull, James A. Kaye and David P. Carbone

    Citation: BMC Cancer 2019 19:353

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  13. Content type: Research article

    High risk human papillomaviruses (HPV) plays important roles in the development of cervical cancer, a number of other anogenital cancer and they are increasingly found in oropharyngeal squamous cell carcinoma ...

    Authors: Ge Gao, Jintu Wang, Jan L. Kasperbauer, Nicole M. Tombers, Fei Teng, Honglan Gou, Yonggang Zhao, Zhenhong Bao and David I. Smith

    Citation: BMC Cancer 2019 19:352

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  14. Content type: Research article

    Optimising breast cancer treatment remains a challenge. Resistance to therapy is a major problem in both ER- and ER+ breast cancer. Tumour recurrence after chemotherapy and/or targeted therapy leads to more ag...

    Authors: Lana McClements, Stephanie Annett, Anita Yakkundi, Martin O’Rourke, Andrea Valentine, Nermeen Moustafa, Abdelrahim Alqudah, Bruno M. Simões, Fiona Furlong, Amy Short, Stuart A. McIntosh, Helen O. McCarthy, Robert B. Clarke and Tracy Robson

    Citation: BMC Cancer 2019 19:351

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  15. Content type: Research article

    Salivary gland carcinoma ranks the sixth in head and neck cancers while it is relatively rare in its incidence. Epidemiological studies have been based mostly on institutional data, leading to selection bias i...

    Authors: Jin-Ye Fu, Chun-Xiao Wu, Shu-Kun Shen, Ying Zheng, Chen-Ping Zhang and Zhi-Yuan Zhang

    Citation: BMC Cancer 2019 19:350

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  16. Content type: Research article

    The exact signalling mechanism of the mTOR complex remains a subject of constant debate, even with some evidence that amino acids participate in the same pathway as used for insulin signalling during protein s...

    Authors: Bread Cruz, André Oliveira, Gislaine Ventrucci and Maria Cristina Cintra Gomes-Marcondes

    Citation: BMC Cancer 2019 19:349

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  17. Content type: Research article

    Extrahepatic cholangiocarcinoma (ECC) has become one of the most rapidly increasing malignancies in China during recent decades. The relationship between tobacco exposure and ECC epidemics is unclear; this stu...

    Authors: Lei Hou, Jingmei Jiang, Boqi Liu, Wei Han, Yanping Wu, Xiaonong Zou, Fang Xue, Yuanli Chen, Biao Zhang, Haiyu Pang, Yuyan Wang, Zixing Wang, Yaoda Hu and Junyao Li

    Citation: BMC Cancer 2019 19:348

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  18. Content type: Case report

    Hematopoietic stem cell transplantation (HSCT) remains an important therapeutic option for many hematologic malignancies. Bone marrow harvesting from an appropriate donor must be conducted for hematopoietic st...

    Authors: Tae-Woo Nam, Hyun-Min Oh, Jae-Eun Lee, Ju-Hyun Kim, Jong-moon Hwang, Eunhee Park and Tae-Du Jung

    Citation: BMC Cancer 2019 19:347

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  19. Content type: Research article

    Prostate cancer is the most common form of cancer in males and accounts for high cancer related deaths. Therapeutic advancement in prostate cancer has not been able to reduce the mortality burden of prostate c...

    Authors: Ankit Tiwari, Bratati Mukherjee, Md. Khurshidul Hassan, Niharika Pattanaik, Archita Mohanty Jaiswal and Manjusha Dixit

    Citation: BMC Cancer 2019 19:346

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  20. Content type: Research article

    Background: Benign breast lesions are the most common diseases in adult women, which have been treated with minimally invasive therapies in recent years. Little is known about the feasibility of Microwave abla...

    Authors: Wei Zhang, Zhan-Qiang Jin, Masoud Baikpour, Jian-Min Li, Hui Zhang, Ting Liang, Xiao-Ming Pan and Wen He

    Citation: BMC Cancer 2019 19:345

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  21. Content type: Study protocol

    This study protocol describes the clinical trial of the Fex-Can intervention, a web-based self-help program targeting sexual dysfunction and fertility-related distress. The psycho-educational intervention has ...

    Authors: C. Lampic, L. Ljungman, C. Micaux Obol, L. E. Eriksson and L. Wettergren

    Citation: BMC Cancer 2019 19:344

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  22. Content type: Research article

    Hepatocellular carcinoma (HCC) is a leading cause of cancer related deaths worldwide. The PI3K cascade is one of the major signaling pathways underlying HCC development and progression. Activating mutations of...

    Authors: Hui Cao, Zhong Xu, Jingxiao Wang, Antonio Cigliano, Maria G. Pilo, Silvia Ribback, Shu Zhang, Yu Qiao, Li Che, Rosa M. Pascale, Diego F. Calvisi and Xin Chen

    Citation: BMC Cancer 2019 19:343

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  23. Content type: Research article

    Outcomes of patients with ovarian high-grade serous carcinoma (HGSC) treated with neoadjuvant chemotherapy (NAC) have been widely studied, but there is limited information on the outcomes of patients with non-...

    Authors: Young Shin Chung, Sang-Yoon Park, Jung-Yun Lee, Jeong-Yeol Park, Jeong-Won Lee, Hee Seung Kim, Dong Soo Suh, Yun Hwan Kim, Jong-Min Lee, Miseon Kim, Min Chul Choi, Seung-Hyuk Shim, Keun Ho Lee, Taejong Song, Jin Hwa Hong, Won Moo Lee…

    Citation: BMC Cancer 2019 19:341

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  24. Content type: Study protocol

    Breast, colorectal, and prostate cancer survivors are at increased risk for late and long-term effects post-treatment. The post-treatment phase of care is often poorly coordinated and survivors navigate follow...

    Authors: Stacy N. Davis, Denalee M. O’Malley, Alicja Bator, Pamela Ohman-Strickland, Lynn Clemow, Jeanne M. Ferrante, Benjamin F. Crabtree, Suzanne M. Miller, Patricia Findley and Shawna V. Hudson

    Citation: BMC Cancer 2019 19:340

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  25. Content type: Study protocol

    Enzalutamide is an oral androgen receptor targeted agent that has been shown to improve survival in PREVAIL trials and has been approved for patients with chemo-naïve metastatic castration-resistant prostate c...

    Authors: Taro Iguchi, Satoshi Tamada, Minoru Kato, Sayaka Yasuda, Takeshi Yamasaki and Tatsuya Nakatani

    Citation: BMC Cancer 2019 19:339

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  26. Content type: Research article

    Incidence of renal dysfunction and risks of progression to end-stage renal disease (ESRD) were reported higher in upper urinary tract urothelial carcinoma (UTUC) than in renal cell carcinoma (RCC) patients aft...

    Authors: Sheng-Wen Niu, Peir-In Liang, Ming-Yen Lin, Shih-Meng Yeh, Yen-Yi Zhen, Yu-Han Chang, Pin-Chia Huang, Chi-Chi Hung, I-Ching Kuo, Hugo You-Hsien Lin, Mei-Chuan Kuo, Wei-Ming Li, Chun-Nung Huang, Wen-Jeng Wu, Li-Tzong Chen, Yi-Wen Chiu…

    Citation: BMC Cancer 2019 19:337

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  27. Content type: Case report

    Abscopal effect is the out-of-field response to localized irradiation therapy that results in systemic antitumorigenic effects such as the regression of a tumor distant from the target site.

    Authors: Aoi Kuroda, Takaya Tabuchi, Eri Iwami, Kotaro Sasahara, Tatsu Matsuzaki, Takahiro Nakajima, Yuki Tsutsumi, Keisuke Eguchi and Takeshi Terashima

    Citation: BMC Cancer 2019 19:336

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  28. Content type: Research article

    Here we describe the treatments and prognosis for metachronous metastases from gastroenteropancreatic neuroendocrine tumors (GEP-NETs) after initial R0 surgical resection at a large center in China.

    Authors: Yang Lv, Xu Han, Xue-Feng Xu, Yuan Ji, Yu-Hong Zhou, Hui-Chuan Sun, Jian Zhou, Jia Fan, Wen-Hui Lou and Cheng Huang

    Citation: BMC Cancer 2019 19:335

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  29. Content type: Research article

    Our aim was to determine the epidemiology and recent changes in the trends of non-functional pancreatic neuroendocrine tumours (NF-pNETs) at the population level. In addition, we explored the risk factors that...

    Authors: Junjun Wu, Chi Sun, Enliang Li, Jiakun Wang, Xianping He, Rongfa Yuan, Chenghao Yi, Wenjun Liao and Linquan Wu

    Citation: BMC Cancer 2019 19:334

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  30. Content type: Research article

    Visceral organ metastasis is associated with poor survival outcomes in terms of metastasis free- and overall survival in breast carcinomas. Identification of a gene expression profile in tumours that selects a...

    Authors: C. D. Savci-Heijink, H. Halfwerk, J. Koster, H. M. Horlings and M. J. van de Vijver

    Citation: BMC Cancer 2019 19:333

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  31. Content type: Research article

    The treatment of patients with glioma depended on the nature of the lesion and on histological grade of the tumor. Positron emission tomography (PET) using 13N-ammonia (NH3), 11C-methionine (MET) and 18F-fluorode...

    Authors: Qiao He, Linqi Zhang, Bing Zhang, Xinchong Shi, Chang Yi and Xiangsong Zhang

    Citation: BMC Cancer 2019 19:332

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  32. Content type: Research article

    Non-muscular invasive bladder cancer (NMIBC) has a high risk of recurrence. As androgen receptor (AR) reportedly affects bladder cancer, we assessed the correlation between NMIBC recurrence and tumor AR expressio...

    Authors: Masato Yasui, Takashi Kawahara, Koji Izumi, Masahiro Yao, Yukari Ishiguro, Hitoshi Ishiguro, Hiroji Uemura and Yasuhide Miyoshi

    Citation: BMC Cancer 2019 19:331

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  33. Content type: Research article

    Decisions made in multidisciplinary tumor conferences (MTC) that consider patient preferences result in better patient outcomes. Furthermore, it has been shown that in some breast cancer centers in Germany, pa...

    Authors: Christian Heuser, Annika Diekmann, Christoph Kowalski, Anna Enders, Rupert Conrad, Holger Pfaff, Lena Ansmann and Nicole Ernstmann

    Citation: BMC Cancer 2019 19:330

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  34. Content type: Research article

    In this study, the influence of the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) on the prognosis of giant cell tumor (GCT) of the extremities were investigated.

    Authors: Zhenhao Chen, Guanglei Zhao, Feiyan Chen, Jun Xia and Li Jiang

    Citation: BMC Cancer 2019 19:329

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  35. Content type: Study protocol

    Recurrences are reported in 70% of all patients after resection of colorectal liver metastases (CRLM), in which half are confined to the liver. Adjuvant hepatic arterial infusion pump (HAIP) chemotherapy aims ...

    Authors: F. E. Buisman, M. Y. V. Homs, D. J. Grünhagen, W. F. Filipe, R. J. Bennink, M. G. H. Besselink, I. H. M. Borel Rinkes, R. C. G. Bruijnen, A. Cercek, M. I. D’Angelica, O. M. van Delden, M. L. Donswijk, L. van Doorn, P. G. Doornebosch, J. Emmering, J. I. Erdmann…

    Citation: BMC Cancer 2019 19:327

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  36. Content type: Research article

    For progressive metastatic medullary thyroid carcinoma (MTC), the available treatment options with tyrosine kinase inhibitors result in grade 3–4 adverse events in a large number of patients. Peptide Receptor ...

    Authors: Carolien M. Beukhof, Tessa Brabander, Francien H. van Nederveen, Marie-Louise F. van Velthuysen, Yolanda B. de Rijke, Leo J. Hofland, Gaston J. H. Franssen, Lideke A. C. Fröberg, Boen L. R. Kam, W. Edward Visser, Wouter W. de Herder and Robin P. Peeters

    Citation: BMC Cancer 2019 19:325

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  37. Content type: Case report

    We are reporting a rare case of MUTYH-associated polyposis, a colorectal cancer hereditary syndrome, diagnosticated after an intussusception. Colorectal cancer is an important cause of cancer related mortality...

    Authors: Gustavo Heluani Antunes de Mesquita, Bárbara Justo Carvalho, Kayo Augusto de Almeida Medeiros, Fernanda Nii, Diego Ramos Martines, Leonardo Zumerkorn Pipek, Yuri Justi Jardim, Daniel Reis Waisberg, Marcos Takeo Obara, Roberta Sitnik, Alberto Meyer and Cristóvão Luis Pitangueiras Mangueira

    Citation: BMC Cancer 2019 19:324

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  38. Content type: Research article

    Multiple trials have attempted to assess the diagnostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in osteosarcoma with results remaining inconclusive. This ...

    Authors: Fanxiao Liu, Qingyu Zhang, Dongsheng Zhou and Jinlei Dong

    Citation: BMC Cancer 2019 19:323

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  39. Content type: Research article

    MYC is a heterogeneously expressed transcription factor that plays a multifunctional role in many biological processes such as cell proliferation and differentiation. It is also associated with many types of c...

    Authors: Karsten Kleo, Lora Dimitrova, Elisabeth Oker, Nancy Tomaszewski, Erika Berg, Franziska Taruttis, Julia C. Engelmann, Philipp Schwarzfischer, Jörg Reinders, Rainer Spang, Wolfram Gronwald, Peter J. Oefner and Michael Hummel

    Citation: BMC Cancer 2019 19:322

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  40. Content type: Research article

    The purpose of this review is to update previously published reviews on exercise programming in exercise trials in prostate cancer survivors. We evaluated: 1) the application of the principles of exercise trai...

    Authors: Sarah E. Neil-Sztramko, Mary E. Medysky, Kristin L. Campbell, Kelcey A. Bland and Kerri M. Winters-Stone

    Citation: BMC Cancer 2019 19:321

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  41. Content type: Case report

    Oesophageal cancer has a high metastatic potential and poor prognosis, with a significant risk of recurrence after radical resection. However, resected pancreatic metastasis from oesophageal cancer is rare.

    Authors: Wataru Koizumi, Minoru Kitago, Masahiro Shinoda, Hiroshi Yagi, Yuta Abe, Go Oshima, Shutaro Hori, Kenta Inomata, Hirofumi Kawakubo, Miho Kawaida and Yuko Kitagawa

    Citation: BMC Cancer 2019 19:320

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  42. Content type: Research article

    Despite the previously suggested role of Neudesin in tumorigenesis and its potential as a novel target for the treatment of cancers, its prognostic value has never been examined. Thus, the aim of the study was...

    Authors: Olga M. Koper-Lenkiewicz, Joanna Kamińska, Anna Milewska, Karol Sawicki, Marek Jadeszko, Zenon Mariak, Joanna Reszeć, Violetta Dymicka-Piekarska and Joanna Matowicka-Karna

    Citation: BMC Cancer 2019 19:319

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  43. Content type: Research article

    The differentiation between pancreatic head cancer (PHC) and distal cholangiocarcinoma (DCC) can be challenging because of their anatomical and histopathological similarity. This is an important problem, becau...

    Authors: Tsutomu Takenami, Shimpei Maeda, Hideaki Karasawa, Takashi Suzuki, Toru Furukawa, Takanori Morikawa, Tatsuyuki Takadate, Hiroki Hayashi, Kei Nakagawa, Fuyuhiko Motoi, Takeshi Naitoh and Michiaki Unno

    Citation: BMC Cancer 2019 19:318

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  44. Content type: Research article

    Regulatory immune cells may modulate the lymphoma microenvironment and are of great interest due to the increasing prevalence of treatment with immunotherapies in lymphoma patients. The aim was to explore the ...

    Authors: R-M Amini, G. Enblad, P. Hollander, S. Laszlo, E. Eriksson, K. Ayoola Gustafsson, A. Loskog and I. Thörn

    Citation: BMC Cancer 2019 19:316

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