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  1. Ovarian carcinoma is a rarely curable disease, for which new treatment options are required. As agents that block HMG-CoA reductase and the mevalonate pathway, the statin family of drugs are used in the treatm...

    Authors: Anna Martirosyan, James W Clendening, Carolyn A Goard and Linda Z Penn
    Citation: BMC Cancer 2010 10:103
  2. An increasing number of studies show that genetic markers can aid in refining prognostic information and predicting the benefit from systemic therapy. Our goal was to develop a high throughput, cost-effective ...

    Authors: Debora Fumagalli, Patrick G Gavin, Yusuke Taniyama, Seung-Il Kim, Hyun-Joo Choi, Soonmyung Paik and Katherine L Pogue-Geile
    Citation: BMC Cancer 2010 10:101
  3. Previous population-based studies showed differences in international and within country colorectal cancer survival estimates, but few investigated the role of prognostic factors. Using a "high resolution appr...

    Authors: Maria Theresa Redaniel, Adriano Laudico, Maria Rica Mirasol-Lumague, Adam Gondos, Gemma Uy and Hermann Brenner
    Citation: BMC Cancer 2010 10:100
  4. BRAF and K-ras proto-oncogenes encode components of the ERK signalling pathway and are frequently mutated in colorectal cancer. This study investigates the associations between BRAF and K-ras mutations and clini...

    Authors: Adam Naguib, Panagiota N Mitrou, Laura J Gay, James C Cooke, Robert N Luben, Richard Y Ball, Alison McTaggart, Mark J Arends and Sheila A Rodwell
    Citation: BMC Cancer 2010 10:99
  5. In the present study, we determined the gene hypermethylation profiles of normal tissues adjacent to invasive breast carcinomas and investigated whether these are associated with the gene hypermethylation prof...

    Authors: Ilse Van der Auwera, Catherine Bovie, Cecilia Svensson, Xuan B Trinh, Ridha Limame, Peter van Dam, Steven J van Laere, Eric A van Marck, Luc Y Dirix and Peter B Vermeulen
    Citation: BMC Cancer 2010 10:97
  6. Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. For effective treatment, local control of the tumor is absolutely critical, because the chances of long term survival a...

    Authors: Claudia Blattmann, Susanne Oertel, Daniela Schulz-Ertner, Stefan Rieken, Sabine Haufe, Volker Ewerbeck, Andreas Unterberg, Irini Karapanagiotou-Schenkel, Stephanie E Combs, Anna Nikoghosyan, Marc Bischof, Oliver Jäkel, Peter Huber, Andreas E Kulozik and Jürgen Debus
    Citation: BMC Cancer 2010 10:96
  7. Invasiveness and metastasis are the most common characteristics of non small cell lung cancer (NSCLC) and causes of tumour-related morbidity and mortality. Mitogen-activated protein kinases (MAPKs) signalling ...

    Authors: Cheng-Jeng Tai, Alexander TH Wu, Jeng-Feng Chiou, Hsun-Jin Jan, Hon-Jian Wei, Chung-Huei Hsu, Che-Tong Lin, Wen-Ta Chiu, Cheng-Wen Wu, Horng-Mo Lee and Win-Ping Deng
    Citation: BMC Cancer 2010 10:95
  8. Remodeling of the extracellular matrix (ECM) has been implicated in ovarian cancer, and we hypothesize that these alterations may provide a better optical marker of early disease than currently available imagi...

    Authors: Oleg Nadiarnykh, Ronald B LaComb, Molly A Brewer and Paul J Campagnola
    Citation: BMC Cancer 2010 10:94
  9. The VEGF family of ligands and receptors are intimately involved in tumor angiogenesis, lymphangiogenesis and metastasis. The evaluation of VEGF ligand/receptor ratios may provide a more profound understanding...

    Authors: Manuela Eppenberger, Inti Zlobec, Daniel Baumhoer, Luigi Terracciano and Alessandro Lugli
    Citation: BMC Cancer 2010 10:93
  10. Squamous cell carcinoma of the head and neck (SCCHN) are highly invasive tumours with frequent local and distant recurrence. Metastasis formation requires degradation of the extracellular matrix, which is fulf...

    Authors: Pamela Zengel, Diana Ramp, Brigitte Mack, Stefan Zahler, Alexander Berghaus, Bernd Muehlenweg, Olivier Gires and Suna Schmitz
    Citation: BMC Cancer 2010 10:92
  11. Glioblastoma multiforme (GBM) is the most aggressive and frequent brain tumor, albeit without cure. Although patient survival is limited to one year on average, significant variability in outcome is observed. ...

    Authors: Marie-Claude Amoureux, Béma Coulibaly, Olivier Chinot, Anderson Loundou, Philippe Metellus, Geneviève Rougon and Dominique Figarella-Branger
    Citation: BMC Cancer 2010 10:91
  12. The purpose of our study was to compare differences in the prognosis of breast cancer (BC) patients at high (H) risk or intermediate slightly (IS) increased risk based on family history and those without a fam...

    Authors: Laura Cortesi, Cristina Masini, Claudia Cirilli, Veronica Medici, Isabella Marchi, Giovanna Cavazzini, Giuseppe Pasini, Daniela Turchetti and Massimo Federico
    Citation: BMC Cancer 2010 10:90
  13. Ovarian cancer still has a relatively poor prognosis due to the frequent occurrence of drug resistance, making the identification of new therapeutic targets an important goal. We have studied the role of HOX gene...

    Authors: Richard Morgan, Lynn Plowright, Kevin J Harrington, Agnieszka Michael and Hardev S Pandha
    Citation: BMC Cancer 2010 10:89
  14. Single nucleotide polymorphism (SNP) 309 resulting in a T or G allele in the promoter of MDM2, the negative regulator of p53, has been suggested to affect cancer predisposition and age of onset, primarily in fema...

    Authors: Hui Wan Chua, Daniel Ng, Serena Choo, San San Lum, Huihua Li, Li Ying Soh, Kanaga Sabapathy and Adeline Seow
    Citation: BMC Cancer 2010 10:88
  15. Dendritic cells (DCs) isolated from tumor bearing animals or from individuals with solid tumors display functional abnormalities and the DC impairment has emerged as one mechanism for tumor evasion from the co...

    Authors: Vegard Tjomsland, Per Sandström, Anna Spångeus, Davorka Messmer, Johan Emilsson, Ursula Falkmer, Sture Falkmer, Karl-Eric Magnusson, Kurt Borch and Marie Larsson
    Citation: BMC Cancer 2010 10:87
  16. Cachexia is a common problem in patients (pts) suffering from upper gastrointestinal cancer. In addition, most of these patients suffer from malabsorption and stenosis of the gastrointestinal tract due to thei...

    Authors: Uwe Pelzer, Dirk Arnold, Mehmet Goevercin, Jens Stieler, Bernd Doerken, Hanno Riess and Helmut Oettle
    Citation: BMC Cancer 2010 10:86
  17. To improve the efficacy of first-line therapy for advanced non-small cell lung cancer (NSCLC), additional maintenance chemotherapy may be given after initial induction chemotherapy in patients who did not prog...

    Authors: Luis G Paz-Ares, Sedat Altug, Alexandra Thareau Vaury, Jesús Corral Jaime, Francesca Russo and Carla Visseren-Grul
    Citation: BMC Cancer 2010 10:85
  18. Aberrant ErbB receptor signaling is associated with various types of malignancies. γ-Tocotrienol is a member of the vitamin E family of compounds that displays potent anticancer activity that is associated wit...

    Authors: Sunitha V Bachawal, Vikram B Wali and Paul W Sylvester
    Citation: BMC Cancer 2010 10:84
  19. The hepaCAM gene encodes a new immunoglobulin-like cell adhesion molecule, and its expression is suppressed in a variety of human cancers. Additionally, hepaCAM possesses properties often observed in tumor sup...

    Authors: Yunfeng He, Xiaohou Wu, Chunli Luo, Lie Wang and Jie Lin
    Citation: BMC Cancer 2010 10:83
  20. The local and systemic activation and regulation of the immune system by malignant cells during carcinogenesis is highly complex with involvement of the innate and acquired immune system. Despite the fact that...

    Authors: Martin Grimm, Martin Gasser, Marco Bueter, Johanna Strehl, Johann Wang, Ekaterina Nichiporuk, Detlef Meyer, Christoph T Germer, Ana M Waaga-Gasser and Andreas Thalheimer
    Citation: BMC Cancer 2010 10:82
  21. Mitochondrial membrane complexes (MMCs) are key mediators of cellular oxidative phosphorylation, and inhibiting them could lead to cell death. No published data are available on the relative abundance of MMCs ...

    Authors: Mark M Aloysius, Abed M Zaitoun, Timothy E Bates, Mohammad Ilyas, Dumitru Constantin-Teodosiu, Brian J Rowlands and Dileep N Lobo
    Citation: BMC Cancer 2010 10:80
  22. Zic zinc finger proteins are present in the developing rodent meninges and are required for cell proliferation and differentiation of meningeal progenitors. Although human ZIC genes are known to be molecular mark...

    Authors: Jun Aruga, Yayoi Nozaki, Minoru Hatayama, Yuri S Odaka and Naoki Yokota
    Citation: BMC Cancer 2010 10:79
  23. Increased transcription of oncogenes like the epidermal growth factor receptor (EGFR) is frequently caused by amplification of the whole gene or at least of regulatory sequences. Aim of this study was to pinpo...

    Authors: Konstantin Agelopoulos, Burkhard Greve, Hartmut Schmidt, Heike Pospisil, Stefan Kurtz, Kai Bartkowiak, Antje Andreas, Marek Wieczorek, Eberhard Korsching, Horst Buerger and Burkhard Brandt
    Citation: BMC Cancer 2010 10:78
  24. Several different gene expression signatures have been proposed to predict response to therapy and clinical outcome in lung adenocarcinoma. Herein, we investigate if elements of published gene sets can be repr...

    Authors: Jens Neumann, Friedrich Feuerhake, Gian Kayser, Thorsten Wiech, Konrad Aumann, Bernward Passlick, Paul Fisch, Martin Werner and Axel zur Hausen
    Citation: BMC Cancer 2010 10:77
  25. HAX-1 has been described as a protein potentially involved in carcinogenesis and especially metastasis. Its involvement in regulation of apoptosis and cell migration along with some data indicating its overexp...

    Authors: Alicja Trebinska, Alina Rembiszewska, Karolina Ciosek, Konrad Ptaszynski, Sebastian Rowinski, Jolanta Kupryjanczyk, Janusz A Siedlecki and Ewa A Grzybowska
    Citation: BMC Cancer 2010 10:76
  26. The short arm of human chromosome 3 is involved in the development of many cancers including lung cancer. Three bona fide lung cancer tumor suppressor genes namely RBSP3 (AP20 region),NPRL2 and RASSF1A (LUCA regi...

    Authors: Vera N Senchenko, Ekaterina A Anedchenko, Tatiana T Kondratieva, George S Krasnov, Alexei A Dmitriev, Veronika I Zabarovska, Tatiana V Pavlova, Vladimir I Kashuba, Michael I Lerman and Eugene R Zabarovsky
    Citation: BMC Cancer 2010 10:75
  27. Gastric cancer is one of the most common malignancies worldwide and the second most common cause of cancer related death. Gene copy number alterations play an important role in the development of gastric cance...

    Authors: Siina Junnila, Arto Kokkola, Marja-Liisa Karjalainen-Lindsberg, Pauli Puolakkainen and Outi Monni
    Citation: BMC Cancer 2010 10:73
  28. The aim of the study was to obtain stable radioresistant sub-lines from the human cervical cancer cell line HeLa by prolonged exposure to 252Cf neutron and X-rays. Radioresistance mechanisms were investigated in ...

    Authors: Yi Qing, Xue-Qin Yang, Zhao-Yang Zhong, Xin Lei, Jia-Yin Xie, Meng-Xia Li, De-Bing Xiang, Zeng-Peng Li, Zhen-Zhou Yang, Ge Wang and Dong Wang
    Citation: BMC Cancer 2010 10:71
  29. The release of proteins from tumors can trigger an immune response in cancer patients involving T lymphocytes and B lymphocytes, which results in the generation of antibodies to tumor-derived proteins. Many st...

    Authors: Susanne Klein-Scory, Salwa Kübler, Hanna Diehl, Christina Eilert-Micus, Anke Reinacher-Schick, Kai Stühler, Bettina Warscheid, Helmut E Meyer, Wolff Schmiegel and Irmgard Schwarte-Waldhoff
    Citation: BMC Cancer 2010 10:70
  30. Chronic inflammation is considered to be implicated in the development of prostate cancer. In this study we are the first to investigate a potential association between variants in an autoimmune related region...

    Authors: Elizabeth A Tindall, Hoa N Hoang, Melissa C Southey, Dallas R English, John L Hopper, Graham G Giles, Gianluca Severi and Vanessa M Hayes
    Citation: BMC Cancer 2010 10:69
  31. There is increasing evidence that cancers contain their own stem-like cells, and particular attention has been paid to one subset of cancer-stem cells termed side population (SP). Stem cells under normal physi...

    Authors: Jun-Xia Cao, Yu-Xin Cui, Zi-Jie Long, Zhong-Min Dai, Ji-Yan Lin, Yi Liang, Fei-Meng Zheng, Yi-Xin Zeng and Quentin Liu
    Citation: BMC Cancer 2010 10:68
  32. Pancreatic cancer is one of the most aggressive human malignancies, with a very poor prognosis. To evaluate the effect of angiotensin II (Ang II) type 2 receptor (AT2) expression in the host's body on the growth ...

    Authors: Chiyo Doi, Noboru Egashira, Atsushi Kawabata, Dharmendra Kumar Maurya, Naomi Ohta, Deepthi Uppalapati, Rie Ayuzawa, Lara Pickel, Yuka Isayama, Deryl Troyer, Susumu Takekoshi and Masaaki Tamura
    Citation: BMC Cancer 2010 10:67
  33. Tumor initiating cells (TICs) provide a new paradigm for developing original therapeutic strategies.

    Authors: Cristina Patru, Luciana Romao, Pascale Varlet, Laure Coulombel, Eric Raponi, Josette Cadusseau, François Renault-Mihara, Cécile Thirant, Nadine Leonard, Alain Berhneim, Maria Mihalescu-Maingot, Jacques Haiech, Ivan Bièche, Vivaldo Moura-Neto, Catherine Daumas-Duport, Marie-Pierre Junier…
    Citation: BMC Cancer 2010 10:66
  34. Survivin, a member of the inhibitor of apoptosis-protein family suppresses apoptosis and regulates cell division. It is strongly overexpressed in the vast majority of cancers. We were interested if survivin de...

    Authors: Helge Taubert, Chris Heidenreich, Hans-Jürgen Holzhausen, Antje Schulz, Matthias Bache, Matthias Kappler, Alexander W Eckert, Peter Würl, Ingo Melcher, Kathrin Hauptmann, Steffen Hauptmann and Klaus-Dieter Schaser
    Citation: BMC Cancer 2010 10:65
  35. Ovarian epithelial cancer (OEC) usually presents in the later stages of the disease. Factors, especially those associated with cell-cycle genes, affecting the genesis and tumour progression for ovarian cancer ...

    Authors: Narasimhan Kothandaraman, Vladimir B Bajic, Pang NK Brendan, Chan Y Huak, Peh B Keow, Khalil Razvi, Manuel Salto-Tellez and Mahesh Choolani
    Citation: BMC Cancer 2010 10:64
  36. Cutaneous melanoma (CM) is the most lethal form of skin malignancy, which registers a constant increase in incidence worldwide. The identification of molecular alteration(s) involved in its biological aggressi...

    Authors: Massimo Mascolo, Maria Luisa Vecchione, Gennaro Ilardi, Massimiliano Scalvenzi, Guido Molea, Maria Di Benedetto, Loredana Nugnes, Maria Siano, Gaetano De Rosa and Stefania Staibano
    Citation: BMC Cancer 2010 10:63
  37. Appendiceal adenocarcinoma is rare with a frequency of 0.08% of all surgically removed appendices. Few cases of appendiceal carcinoma infiltrating the bladder wall for spatial contiguity have been documented.

    Authors: Gianluigi Taverna, Matteo Corinti, Piergiuseppe Colombo, Fabio Grizzi, Mauro Severo, Alessando Piccinelli, Guido Giusti, Alessio Benetti, Paolo A Zucali and Pierpaolo Graziotti
    Citation: BMC Cancer 2010 10:62
  38. It has been suggested that columnar cell lesions indicate an alteration of the human mammary gland involved in the development of breast cancer. They have not previously been described in canine mammary gland....

    Authors: Enio Ferreira, Helenice Gobbi, Bruna S Saraiva and Geovanni D Cassali
    Citation: BMC Cancer 2010 10:61
  39. Pancreatic ductal adenocarcinoma is a lethal disease with a 5-year survival rate of 4% and typically presents in an advanced stage. In this setting, prognostic markers identifying the more agrressive tumors co...

    Authors: David F Schaeffer, Daniel R Owen, Howard J Lim, Andrew K Buczkowski, Stephen W Chung, Charles H Scudamore, David G Huntsman, Sylvia SW Ng and David A Owen
    Citation: BMC Cancer 2010 10:59
  40. PMS2 expression loss was reported in a variety of human. However, its importance has not been fully understood in cervical carcinoma. The aim of this study was to determine the expression of PMS2 in cervical c...

    Authors: Yuan Zhang, Yi Min Shu, Shu Fang Wang, Bang Hong Da, Ze Hua Wang and Hua Bin Li
    Citation: BMC Cancer 2010 10:58
  41. We have recently described the correlation between quantitative measures of HER2 expression or HER2 homodimers by the HERmark assay and objective response (RR), time-to progression (TTP), and overall survival ...

    Authors: Masakazu Toi, Jeff Sperinde, Weidong Huang, Shigehira Saji, John Winslow, Xueguang Jin, Yuping Tan, Shinji Ohno, Seigo Nakamura, Hiroji Iwata, Norikazu Masuda, Kenjiro Aogi, Satoshi Morita, Christos Petropoulos and Michael Bates
    Citation: BMC Cancer 2010 10:56
  42. Non-Hodgkin lymphoma (NHL) is a hematologic malignancy for which good diagnostic markers are lacking. Despite continued improvement in our understanding of NHL, efforts to identify diagnostic markers have yiel...

    Authors: Byong Chul Yoo, Sun-Young Kong, Sang-Geun Jang, Kyung-Hee Kim, Sun-A Ahn, Weon-Seo Park, Sohee Park, Tak Yun and Hyeon-Seok Eom
    Citation: BMC Cancer 2010 10:55
  43. We evaluated two molecular methods of HPV detection and their correlation with cytological and histological diagnosis in a large sample of Greek women.

    Authors: Sotirios Tsiodras, John Georgoulakis, Aikaterini Chranioti, Zanis Voulgaris, Amanda Psyrri, Angeliki Tsivilika, John Panayiotides and Petros Karakitsos
    Citation: BMC Cancer 2010 10:53
  44. Osteosarcoma often develops micrometastases in the lung prior to diagnosis, causing a fatal outcome. Therefore, the prevention of pulmonary metastases is critical for the improvement of the prognosis of patien...

    Authors: Junichi Aizawa, Kenshi Sakayama, Setsuya Kamei, Teruki Kidani, Haruyasu Yamamoto, Yoshiaki Norimatsu and Hiroshi Masuno
    Citation: BMC Cancer 2010 10:51

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