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  1. Ovarian tumors create a dynamic microenvironment that promotes angiogenesis and reduces immune responses. Our research has revealed that threonyl-tRNA synthetase (TARS) has an extracellular angiogenic activity...

    Authors: Theresa L Wellman, Midori Eckenstein, Cheung Wong, Mercedes Rincon, Takamaru Ashikaga, Sharon L Mount, Christopher S Francklyn and Karen M Lounsbury
    Citation: BMC Cancer 2014 14:620
    Content type: Research article Published on:

  2. To assess the safety and efficacy of Stereotactic Ablative Radiotherapy (SABR) in oligometastatic patients from colorectal cancer.

    Authors: Tiziana Comito, Luca Cozzi, Elena Clerici, Maria Concetta Campisi, Rocco Luca Emanuele Liardo, Pierina Navarria, AnnaMaria Ascolese, Angelo Tozzi, Cristina Iftode, Fiorenza De Rose, Elisa Villa, Nicola Personeni, Lorenza Rimassa, Armando Santoro, Antonella Fogliata, Pietro Mancosu…
    Citation: BMC Cancer 2014 14:619
    Content type: Research article Published on:

  4. To report an unplanned interim analysis of a prospective, one-armed, single center phase I/II trial (NCT01566123).

    Authors: Falk Roeder, Alexis Ulrich, Gregor Habl, Matthias Uhl, Ladan Saleh-Ebrahimi, Peter E Huber, Daniela Schulz-Ertner, Anna V Nikoghosyan, Ingo Alldinger, Robert Krempien, Gunhild Mechtersheimer, Frank W Hensley, Juergen Debus and Marc Bischof
    Citation: BMC Cancer 2014 14:617
    Content type: Research article Published on:

  5. The aberrant expression of microRNAs has been demonstrated to play a crucial role in the initiation and progression of hepatocarcinoma. miR-1246 expression in High invasive ability cell line than significantly...

    Authors: Zhao Sun, Changting Meng, Shihua Wang, Na Zhou, Mei Guan, Chunmei Bai, Shan Lu, Qin Han and Robert Chunhua Zhao
    Citation: BMC Cancer 2014 14:616
    Content type: Research article Published on:

  6. Heat shock protein (Hsp) 90 and Hsp70 are indispensable for cell survival under conditions of stress. They bind to client proteins to assist in protein stabilization, translocation of polypeptides across the c...

    Authors: Tomohisa Horibe, Aya Torisawa, Masayuki Kohno and Koji Kawakami
    Citation: BMC Cancer 2014 14:615
    Content type: Research article Published on:

  7. Most cancer patients are treated with radiotherapy, but the treatment can also damage the surrounding normal tissue. Acute skin damage from cancer radiotherapy diminishes patients’ quality of life, yet effecti...

    Authors: Elina Korpela, Darren Yohan, Lee CL Chin, Anthony Kim, Xiaoyong Huang, Shachar Sade, Paul Van Slyke, Daniel J Dumont and Stanley K Liu
    Citation: BMC Cancer 2014 14:614
    Content type: Research article Published on:

  8. Pelvic lymph nodes removed during radical retropubic prostatectomy for prostatic cancer can be found on pathological examination to harbor various unexpected pathologies. Among these, hematologic neoplasms are...

    Authors: Antonio Di Meglio, Pier Vitale Nuzzo, Francesco Ricci, Bruno Spina and Francesco Boccardo
    Citation: BMC Cancer 2014 14:613
    Content type: Case report Published on:

  9. There is a lack of standardized definition for treatment-related mortality (TRM), which represents an important endpoint in cancer. Our objective was to describe TRM definitions used in studies of children, ad...

    Authors: Thai Hoa Tran, Michelle Lee, Sarah Alexander, Paul Gibson, Ute Bartels, Donna L Johnston, Carol Portwine, Marianna Silva, Jason D Pole and Lillian Sung
    Citation: BMC Cancer 2014 14:612
    Content type: Research article Published on:

  10. Although the incidence of glioma is relatively low, it is the most malignant tumor of the central nervous system. The prognosis of high-grade glioma patient is very poor due to the difficulties in complete res...

    Authors: Yan-chang Sun, Jing Wang, Cheng-cheng Guo, Ke Sai, Jian Wang, Fu-rong Chen, Qun-ying Yang, Yin-sheng Chen, Jie Wang, Tony Shing-shun To, Zong-ping Zhang, Yong-gao Mu and Zhong-ping Chen
    Citation: BMC Cancer 2014 14:611
    Content type: Research article Published on:

  11. The rapid aging of the population in Japan has been accompanied by an increased rate of surgery for lung cancer among elderly patients. It is thus an urgent priority to map out a treatment strategy for elderly...

    Authors: Teppei Nishii, Tomoyuki Yokose, Yohei Miyagi, Yataro Daigo, Hiroyuki Ito, Tetsuya Isaka, Kentaro Imai, Shuji Murakami, Tetsuro Kondo, Haruhiro Saito, Fumihiro Oshita, Kouzo Yamada, Shoichi Matsukuma, Masahiro Tsuboi, Haruhiko Nakayama and Munetaka Masuda
    Citation: BMC Cancer 2014 14:610
    Content type: Research article Published on:

  13. The role of postoperative adjuvant treatment for sinonasal malignant melanoma remains unclear. This study evaluates the impact of three different surgical and postoperative adjuvant treatment modalities: surge...

    Authors: Xin-Jun Meng, Hua-Fei Ao, Wei-Ting Huang, Fu Chen, Xi-Cai Sun, Jing-Jing Wang, Zhuo-Fu Liu, Wade W Han, Allison N Fry and De-Hui Wang
    Citation: BMC Cancer 2014 14:608
    Content type: Research article Published on:

  14. Both laparoscopic and fast-track surgery (FTS) have shown some advantages in colorectal surgery. However, the effectiveness of using both methods together is unclear. We performed this meta-analysis to compare...

    Authors: Jun-hua Zhao, Jing-xu Sun, Peng Gao, Xiao-wan Chen, Yong-xi Song, Xuan-zhang Huang, Hui-mian Xu and Zhen-ning Wang
    Citation: BMC Cancer 2014 14:607
    Content type: Research article Published on:

  15. The standard therapy regimen of conventional osteosarcoma includes neoadjuvant chemotherapy followed by surgical resection and postoperative chemotherapy. The percentage of necrotic tissue following induction ...

    Authors: Sébastien Salas, Carine Jiguet-Jiglaire, Loic Campion, Catherine Bartoli, Frédéric Frassineti, Jean-Laurent Deville, André Maues De Paula, Fabien Forest, Pascal Jézéquel, Jean-Claude Gentet and Corinne Bouvier
    Citation: BMC Cancer 2014 14:606
    Content type: Research article Published on:

  16. The VELOUR study demonstrated a survival benefit for FOLFIRI + aflibercept versus FOLFIRI + placebo in metastatic colorectal cancer (mCRC) patients who progressed on oxaliplatin-based chemotherapy. Continued d...

    Authors: Ian Chau, Florence Joulain, Sheikh Usman Iqbal and John Bridgewater
    Citation: BMC Cancer 2014 14:605
    Content type: Research article Published on:

  17. Breast cancer is a heterogeneous disease with a highly variable clinical outcome in which both genetic and epigenetic changes have critical roles. We investigated tumor expression levels of histone-modifying e...

    Authors: Remco S Derr, Anneke Q van Hoesel, Anne Benard, Inès J Goossens-Beumer, Anita Sajet, N Geeske Dekker-Ensink, Esther M de Kruijf, Esther Bastiaannet, Vincent THBM Smit, Cornelis JH van de Velde and Peter JK Kuppen
    Citation: BMC Cancer 2014 14:604
    Content type: Research article Published on:

  18. Hepatocellular carcinoma is the third cause of cancer related death for which new treatment strategies are needed. Targeting DNA repair pathways to sensitize tumor cells to chemo- or radiotherapy is under inve...

    Authors: Clément Guillot, Vincent Favaudon, Zdenko Herceg, Charlotte Sagne, Sylvie Sauvaigo, Philippe Merle, Janet Hall and Isabelle Chemin
    Citation: BMC Cancer 2014 14:603
    Content type: Research article Published on:

  19. We have previously reported overexpression of the immunoregulatory protein B7-H3 in colorectal cancer and that nuclear expression predicted poor outcome in colon cancer patients. The present study was performe...

    Authors: Vibeke A Ingebrigtsen, Kjetil Boye, Jahn M Nesland, Arild Nesbakken, Kjersti Flatmark and Øystein Fodstad
    Citation: BMC Cancer 2014 14:602
    Content type: Research article Published on:

  20. Patients with single hepatocellular carcinoma (HCC) usually undergo transarterial chemoembolization (TACE) if they are not candidates for curative surgical or ablative therapy. The primary aim of the study was...

    Authors: Eleonora Terzi, Fabio Piscaglia, Ludovica Forlani, Cristina Mosconi, Matteo Renzulli, Luigi Bolondi and Rita Golfieri
    Citation: BMC Cancer 2014 14:601
    Content type: Research article Published on:

  21. The crosstalk between Hedgehog (HH) signaling and other signal transduction cascades has been extensively studied in different cancers. In neuroblastoma, mTOR/S6K1 signaling is known to have a role in the deve...

    Authors: Yumei Diao, Mohammed Ferdous-Ur Rahman, Victoria E Villegas, Malin Wickström, John I Johnsen and Peter G Zaphiropoulos
    Citation: BMC Cancer 2014 14:600
    Content type: Research article Published on:

  22. The nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway is activated in cells exposed to various stimuli, including those originating on the cell surface or in the nucleus....

    Authors: Temesgen Samuel, Khalda Fadlalla, Dominique N Gales, Balananda DK Putcha and Upender Manne
    Citation: BMC Cancer 2014 14:599
    Content type: Research article Published on:

  23. Despite advances in the treatment of primary breast tumors, the outcome of metastatic breast cancer remains dismal. Brain metastases present a particularly difficult therapeutic target due to the “sanctuary” s...

    Authors: Yuriy Shapovalov, Martha Zettel, Sara C Spielman, Stacy A Amico-Ruvio, Emily A Kelly, Grayson O Sipe, Ian M Dickerson, Ania K Majewska and Edward B Brown
    Citation: BMC Cancer 2014 14:598
    Content type: Research article Published on:

  24. Cancer is often described as the ‘number one’ health fear, but little is known about whether this affects quality of life by translating into high levels of worry or distress in everyday life, or which populat...

    Authors: Charlotte Vrinten, Cornelia H M van Jaarsveld, Jo Waller, Christian von Wagner and Jane Wardle
    Citation: BMC Cancer 2014 14:597
    Content type: Research article Published on:

  25. Treatment variation is an important issue in health care provision. An external peer review programme for multidisciplinary cancer care was introduced in 1994 in the Netherlands to improve the multidisciplinar...

    Authors: Melvin J Kilsdonk, Boukje AC van Dijk, Renee Otter, Wim H van Harten and Sabine Siesling
    Citation: BMC Cancer 2014 14:596
    Content type: Research article Published on:

  27. Regions within solid tumours often experience oxygen deprivation, which is associated with resistance to chemotherapy and irradiation. The aim of this study was to evaluate the radiosensitising effect of gemci...

    Authors: An Wouters, Bea Pauwels, Natalie Burrows, Marc Baay, Vanessa Deschoolmeester, Trung Nghia Vu, Kris Laukens, Paul Meijnders, Dirk Van Gestel, Kaye J Williams, Danielle Van den Weyngaert, Jan B Vermorken, Patrick Pauwels, Marc Peeters and Filip Lardon
    Citation: BMC Cancer 2014 14:594
    Content type: Research article Published on:

  28. In cancer patients where gastrointestinal function is marginal and malnutrition significant enough to result in the requirement for intensive nutrition support, parenteral nutrition (PN) is indicated. This lon...

    Authors: Pankaj G Vashi, Sadie Dahlk, Brenten Popiel, Carolyn A Lammersfeld, Carol Ireton-Jones and Digant Gupta
    Citation: BMC Cancer 2014 14:593
    Content type: Research article Published on:

  29. Based on improved clinical outcomes in randomized controlled clinical trials (RCTs) the FDA and EMA have approved bevacizumab with interferon, sunitinib, and pazopanib in the first-line treatment of low to int...

    Authors: Benjamin Haaland, Akhil Chopra, Sanchalika Acharyya, André P Fay and Gilberto de Lima Lopes
    Citation: BMC Cancer 2014 14:592
    Content type: Research article Published on:

  30. The cytokine TRAIL (tumor necrotic factor-related apoptosis-inducing ligand) selectively induces apoptosis in cancer cells, but cancer stem cells (CSCs) that contribute to cancer-recurrence are frequently TRAI...

    Authors: Dan Wang, Bijaya Upadhyaya, Yi Liu, David Knudsen and Moul Dey
    Citation: BMC Cancer 2014 14:591
    Content type: Research article Published on:

  31. Neoplastic and bland portal vein thrombi (PVT) are both common in patients with hepatocellular carcinoma (HCC). The correct discrimination of them is essential for therapeutic strategies planning and survival ...

    Authors: Chuanming Li, Jiani Hu, Daiquan Zhou, Jun Zhao, Kuansheng Ma, Xuntao Yin and Jian Wang
    Citation: BMC Cancer 2014 14:590
    Content type: Research article Published on:

  32. This study was performed to develop a validated score predicting ambulatory status after radiotherapy (RT) alone for metastatic spinal cord compression (MSCC) in elderly patients.

    Authors: Dirk Rades, Jasmin N Evers, Volker Rudat, Amira Bajrovic, Johann H Karstens and Steven E Schild
    Citation: BMC Cancer 2014 14:589
    Content type: Research article Published on:

  33. Lung cancer cells have been reported to produce cytokines, resulting in systemic reactions. There have been few reports showing that these cytokines induced the formation of an inflammatory mass around lung ca...

    Authors: Masataka Matsumoto, Takashi Nakayama, Daiki Inoue, Kazufumi Takamatsu, Ryo Itotani, Manabu Ishitoko, Shinko Suzuki, Minoru Sakuramoto, Yoshiaki Yuba, Osamu Yoshie, Masaya Takemura and Motonari Fukui
    Citation: BMC Cancer 2014 14:588
    Content type: Case report Published on:

  34. In the process of epithelial mesenchymal transition EMT, the disassembly of junctional adhesion complexes such as E-cadherin is a remarkable sign during changes in cell morphology and polarity. However, E-cadh...

    Authors: Yuan-Chiang Chung, Wan-Chen Wei, Shin-Han Huang, Chi-Min Shih, Chih-Ping Hsu, King-Jen Chang and Wei-Ting Chao
    Citation: BMC Cancer 2014 14:587
    Content type: Research article Published on:

  35. Current treatment of diffuse-large-B-cell lymphoma (DLBCL) includes rituximab, an expensive drug, combined with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy. Economic models h...

    Authors: Sara Khor, Jaclyn Beca, Murray Krahn, David Hodgson, Linda Lee, Michael Crump, Karen E Bremner, Jin Luo, Muhammad Mamdani, Chaim M Bell, Carol Sawka, Scott Gavura, Terrence Sullivan, Maureen Trudeau, Stuart Peacock and Jeffrey S Hoch
    Citation: BMC Cancer 2014 14:586
    Content type: Research article Published on:

  36. The purpose of this study was to evaluate the prognostic implication of findings of intratumoral metabolic heterogeneity on pretreatment 18F-FDG PET/CT scans in patients with invasive ductal carcinoma (IDC) of th...

    Authors: Seung Hyun Son, Do-Hoon Kim, Chae Moon Hong, Choon-Young Kim, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee and Byeong-Cheol Ahn
    Citation: BMC Cancer 2014 14:585
    Content type: Research article Published on:

  37. Increasing focus on potentially unnecessary diagnosis and treatment of certain breast cancers prompted our investigation of whether clinical and mammographic features predictive of invasive breast cancer versu...

    Authors: Mehmet US Ayvaci, Oguzhan Alagoz, Jagpreet Chhatwal, Alejandro Munoz del Rio, Edward A Sickles, Houssam Nassif, Karla Kerlikowske and Elizabeth S Burnside
    Citation: BMC Cancer 2014 14:584
    Content type: Research article Published on:

  38. Hemostatic alterations occur during the development of cancer. Plasma D-dimer is a hypercoagulability and fibrinolytic system marker that is increased in patients with various solid tumours. The aim of this st...

    Authors: Wen-Hui Chen, Lin-Quan Tang, Feng-Wei Wang, Chang-Peng Li, Xiao-Peng Tian, Xiao-Xia Huang, Shi-Juan Mai, Yi-Ji Liao, Hai-Xia Deng, Qiu-Yan Chen, Huai Liu, Lu Zhang, Shan-Shan Guo, Li-Ting Liu, Shu-Mei Yan, Chao-Feng Li…
    Citation: BMC Cancer 2014 14:583
    Content type: Research article Published on:

  39. A specific targeting modality for hepatocellular carcinoma (HCC) could ideally encompass a liver cell specific delivery system of a transcriptional unit that is active only in neoplastic cells. Sendai virosome...

    Authors: Mohammad Khalid Zakaria, Imran Khan, Prashant Mani, Parthaprasad Chattopadhyay, Debi P Sarkar and Subrata Sinha
    Citation: BMC Cancer 2014 14:582
    Content type: Research article Published on:

  40. Differences in cancer awareness between individuals may explain variations in healthcare seeking behaviour and ultimately also variations in cancer survival. It is therefore important to examine cancer awarene...

    Authors: Line Hvidberg, Anette Fischer Pedersen, Christian Nielsen Wulff and Peter Vedsted
    Citation: BMC Cancer 2014 14:581
    Content type: Research article Published on:

  41. Transforming growth factor (TGF)-β plays a pivotal role in cancer progression through regulating cancer cell proliferation, invasion, and remodeling of the tumor microenvironment. Cancer-associated fibroblasts...

    Authors: Masafumi Horie, Akira Saito, Satoshi Noguchi, Yoko Yamaguchi, Mitsuhiro Ohshima, Yasuyuki Morishita, Hiroshi I Suzuki, Tadashi Kohyama and Takahide Nagase
    Citation: BMC Cancer 2014 14:580
    Content type: Research article Published on:

  42. Seroepidemiological studies have reported associations between exposure to sexually transmitted organisms and prostate cancer risk. This study sought DNA evidence of candidate organisms in archival prostate ca...

    Authors: Melissa A Yow, Sepehr N Tabrizi, Gianluca Severi, Damien M Bolton, John Pedersen, Anthony Longano, Suzanne M Garland, Melissa C Southey and Graham G Giles
    Citation: BMC Cancer 2014 14:579
    Content type: Research article Published on:

  43. Macrophage inhibitory cytokine 1 (MIC-1/GDF15) has been identified as a potential novel biomarker for detection of pancreatic cancer (PCa). However, the diagnostic value of serum MIC-1 for pancreatic ductal ad...

    Authors: Xiaobing Wang, Yanfen Li, Haimei Tian, Jun Qi, Mo Li, Chao Fu, Fan Wu, Yi Wang, Dongwan Cheng, Wenya Zhao, Chao Zhang, Teng Wang, Jianyu Rao and Wei Zhang
    Citation: BMC Cancer 2014 14:578
    Content type: Research article Published on:

  44. CDK11p58, a Ser/Thr kinase that belongs to the cell division cycle 2-like 1 (CDC2L1) subfamily, is associated with cell cycle progression, tumorigenesis and apoptotic signaling. CDK11p58 is also involved in the r...

    Authors: Yayun Chi, Sheng Huang, Lei Wang, Ruoji Zhou, Lisha Wang, Xiuying Xiao, Dali Li, Ying Cai, Xiaoyan Zhou and Jiong Wu
    Citation: BMC Cancer 2014 14:577
    Content type: Research article Published on:

  45. We previously reported that polyploid giant cancer cells (PGCCs) exhibit cancer stem cell properties and express cell cycle-related proteins. HEY PGCCs induced by cobalt chloride generated daughter cells and t...

    Authors: Hongcheng Lv, Yang Shi, Li Zhang, Dan Zhang, Guang Liu, Zhengduo Yang, Yan Li, Fei Fei and Shiwu Zhang
    Citation: BMC Cancer 2014 14:576
    Content type: Research article Published on:

  46. GIST patients often undergo GI-surgery. Previous studies have shown that imatinib and nilotinib exposures were decreased in GIST patients with prior major gastrectomy. We investigated whether major gastrectomy...

    Authors: Djoeke de Wit, Nielka P van Erp, Reza Khosravan, Robin Wiltshire, Randy Allred, George D Demetri, Henk-Jan Guchelaar and Hans Gelderblom
    Citation: BMC Cancer 2014 14:575
    Content type: Research article Published on:

  47. Poor attendance to cervical cancer (CC) screening is a major risk factor for CC. Efforts to capture underscreened women are considerable and once women agree to participate, the provision of longitudinal valid...

    Authors: Raquel Ibáñez, Josefina Autonell, Montserrat Sardà, Nayade Crespo, Pilar Pique, Amparo Pascual, Clara Martí, Montserrat Fibla, Cristina Gutiérrez, Belén Lloveras, Judit Moreno-Crespi, Anna Torrent, Núria Baixeras, María Alejo, Francesc Xavier Bosch and Silvia de Sanjosé
    Citation: BMC Cancer 2014 14:574
    Content type: Research article Published on:

  49. Golgi phosphoprotein 3 (GOLPH3) has been identified as an oncoprotein in various human cancers; however, its role in pancreatic ductal adenocarcinoma (PDAC) is unknown. We examined GOLPH3 expression levels and...

    Authors: Luan-Jing Zhang, Ke-Bing Wang, Long-shan Liu, Lian-zhou Chen, Bao-Gang Peng, Li-Jian Liang, Zhi Li, Ling Xue, Wen Li and Jing-Tang Xia
    Citation: BMC Cancer 2014 14:571
    Content type: Research article Published on:

  50. Increasingly, the role of chronic inflammation and its mediators in tumor generation and progression is gaining importance in the field of cancer research. In this context, candidature of non steroidal anti-in...

    Authors: Jolly Deb, Joydeb Majumder, Sankar Bhattacharyya and Siddhartha Sankar Jana
    Citation: BMC Cancer 2014 14:567
    Content type: Research article Published on:

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