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  1. Tumour phenotype is regulated in a complex fashion as a result of interactions between malignant cells and the tumour stroma. Fibroblasts are the most abundant and perhaps most active part of the tumour stroma...

    Authors: Charlotta J Olsen, José Moreira, Eugene M Lukanidin and Noona S Ambartsumian
    Citation: BMC Cancer 2010 10:444
  2. In addition to regulating platelet function, the G protein-coupled sub-family member Proteinase-activated receptor-1 (PAR1) has a proposed role in the development of various cancers, but its exact role and mec...

    Authors: Daisuke Fujimoto, Yasuo Hirono, Takanori Goi, Kanji Katayama, Shigeru Matsukawa and Akio Yamaguchi
    Citation: BMC Cancer 2010 10:443
  3. Pancreatic cancer is a complex genetic disorder that is characterized by rapid progression, invasiveness, resistance to treatment and high molecular heterogeneity. Various agents have been used in clinical tri...

    Authors: Jan N Kreutzer, Maria Ruzzene and Barbara Guerra
    Citation: BMC Cancer 2010 10:440
  4. DNA repair capacity is an important determinant of susceptibility to cancer. The hOGG1 enzyme is crucial for repairing the 8-oxoguanine lesion that occurs either as a byproduct of oxidative metabolism or as a ...

    Authors: Randa A El-Zein, Claudia M Monroy, Andrea Cortes, Margaret R Spitz, Anthony Greisinger and Carol J Etzel
    Citation: BMC Cancer 2010 10:439
  5. Imatinib mesylate has been used for the treatment of unresectable or metastatic gastrointestinal stromal tumors (GIST). The current recommended dose of imatinib is 400 mg/day that is increased to 800 mg/day in...

    Authors: Jun-Eul Hwang, Ju-Young Yoon, Woo-Kyun Bae, Hyun-Jeong Shim, Sang-Hee Cho and Ik-Joo Chung
    Citation: BMC Cancer 2010 10:438
  6. Nuclear factor-kappa B (NF-κB) signaling constitutes a key event in the multistep process of carcinogenesis, progression and treatment in many cancer types. However, the significance of NF-κB pathway for compl...

    Authors: Ming Yan, Qin Xu, Ping Zhang, Xiao-jian Zhou, Zhi-yuan Zhang and Wan-tao Chen
    Citation: BMC Cancer 2010 10:437
  7. We investigated the distribution and clinical significance of mobilized endothelial progenitor cells (EPCs) in hepatocellular carcinoma (HCC). We found that many more EPCs were recruited to nonmalignant liver ...

    Authors: De-cai Yu, Jun Chen, Xi-tai Sun, Lin-yuan Zhuang, Chun-ping Jiang and Yi-tao Ding
    Citation: BMC Cancer 2010 10:435
  8. Heterogeneous nuclear ribonucleoproteins (hnRNPs) of the A/B type (hnRNP A1, A2/B1, A3) are highly related multifunctional proteins participating in alternative splicing by antagonising other splicing factors,...

    Authors: Georgios Boukakis, Meropi Patrinou-Georgoula, Maria Lekarakou, Christos Valavanis and Apostolia Guialis
    Citation: BMC Cancer 2010 10:434
  9. Increased concentrations of choline-containing compounds are frequently observed in breast carcinomas, and may serve as biomarkers for both diagnostic and treatment monitoring purposes. However, underlying mec...

    Authors: Siver A Moestue, Eldrid Borgan, Else M Huuse, Evita M Lindholm, Beathe Sitter, Anne-Lise Børresen-Dale, Olav Engebraaten, Gunhild M Mælandsmo and Ingrid S Gribbestad
    Citation: BMC Cancer 2010 10:433
  10. Cervical dysplasia and tumorigenesis have been linked with numerous chromosomal aberrations. The goal of this study was to evaluate 35 genomic regions associated with cervical disease and to select those which...

    Authors: Frank A Policht, Minghao Song, Svetlana Sitailo, Anna O'Hare, Raheela Ashfaq, Carolyn Y Muller, Larry E Morrison, Walter King and Irina A Sokolova
    Citation: BMC Cancer 2010 10:432
  11. Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis involving in carcinogenesis, including lung cancer. We hypothesized that VEGF polymorphisms may affect survival outcomes among locally...

    Authors: Xiaoxiang Guan, Ming Yin, Qingyi Wei, Hui Zhao, Zhensheng Liu, Li-E Wang, Xianglin Yuan, Michael S O'Reilly, Ritsuko Komaki and Zhongxing Liao
    Citation: BMC Cancer 2010 10:431
  12. The integration of the non-cross-resistant chemotherapeutic agents capecitabine and vinorelbine into an intensified dose-dense sequential anthracycline- and taxane-containing regimen in high-risk early breast ...

    Authors: Volkmar Müller, Christoph Thomssen, Marcus Schmidt, Manfred Glados, Christian Jackisch, Volker Heilmann, Axel Hinke, Antje Lehnert, Henryk Borowicz and Volker Möbus
    Citation: BMC Cancer 2010 10:430
  13. The putative tumor metastasis suppressor 1(MTSS1) is an actin-binding scaffold protein that has been implicated to play an important role in carcinogenesis and cancer metastasis, yet its role in the developmen...

    Authors: Ke Liu, Gefang Wang, Houzhong Ding, Ying Chen, Guanzhen Yu and Jiejun Wang
    Citation: BMC Cancer 2010 10:428
  14. Extracellular human sulfatases modulate growth factor signaling by alteration of the heparin/heparan sulfate proteoglycan (HSPG) 6-O-sulfation state. HSPGs bind to numerous growth factor ligands including fibrobl...

    Authors: Sarah M Peterson, Andrea Iskenderian, Lynette Cook, Alla Romashko, Kristen Tobin, Michael Jones, Angela Norton, Alicia Gómez-Yafal, Michael W Heartlein, Michael F Concino, Lucy Liaw and Paolo GV Martini
    Citation: BMC Cancer 2010 10:427
  15. We are developing a cross-species comparison strategy to distinguish between cancer driver- and passenger gene alteration candidates, by utilizing the difference in genomic location of orthologous genes betwee...

    Authors: Xinglai Ji, Jie Tang, Richard Halberg, Dana Busam, Steve Ferriera, Maria Marjorette O Peña, Chinnambally Venkataramu, Timothy J Yeatman and Shaying Zhao
    Citation: BMC Cancer 2010 10:426
  16. As EBV-associated gastric cancer has unique features that are different from EBV (-) gastric cancer, EBV is considered to have a key role in gastric carcinogenesis. It has been reported that viral latent membr...

    Authors: Jung-Young Shin, Jeong-Oh Kim, Suk Kyeong Lee, Hiun-Suk Chae and Jin-Hyoung Kang
    Citation: BMC Cancer 2010 10:425
  17. Gliomatosis cerebri (GC) is characterized by a diffuse infiltration of tumor cells throughout CNS, however, few details are available about the chemotherapeutic effect on GC. The aim of this study was to inves...

    Authors: Doo-Sik Kong, Sung Tae Kim, Jung-Il Lee, Yeon-Lim Suh, Do Hoon Lim, Won Seog Kim, Ki-Hoon Kwon, Kwan Park, Jong Hyun Kim and Do-Hyun Nam
    Citation: BMC Cancer 2010 10:424
  18. Skeletal metastases are often accompanied by bone pain. To investigate the clinical meaning of bone pain associated with skeletal metastasis in breast cancer patients after surgery, we explored whether the pre...

    Authors: Mitsuru Koizumi, Masataka Yoshimoto, Fujio Kasumi, Takuji Iwase and Etsuro Ogata
    Citation: BMC Cancer 2010 10:423
  19. Cigarette smoking is the most established risk factor, and genetic variants and/or gene promoter methylations are also considered to play an essential role in development of lung cancer, but the pathogenesis o...

    Authors: Yongtang Jin, Heyun Xu, Chunye zhang, Yunming Kong, Yong Hou, Yingchun Xu and Shaoli Xue
    Citation: BMC Cancer 2010 10:422
  20. Mitochondrial DNA (mtDNA) haplogroups and single nucleotide polymorphisms (mtSNP) have been shown to play a role in various human conditions including aging and some neurodegenerative diseases, metabolic disea...

    Authors: Hezhi Fang, Lijun Shen, Tao Chen, Jing He, Zhinan Ding, Jia Wei, Jianchun Qu, Guorong Chen, Jianxin Lu and Yidong Bai
    Citation: BMC Cancer 2010 10:421
  21. CYP1B1 is a P450 enzyme which is involved in the activation of pro-carcinogens to carcinogens as well as sex hormone metabolism. Because differences in the activity of the enzyme have been correlated with vari...

    Authors: Joanna Trubicka, Ewa Grabowska-Kłujszo, Janina Suchy, Bartłomiej Masojć, Pablo Serrano-Fernandez, Grzegorz Kurzawski, Cezary Cybulski, Bohdan Górski, Tomasz Huzarski, Tomasz Byrski, Jacek Gronwald, Elżbieta Złowocka, Józef Kładny, Zbigniew Banaszkiewicz, Rafał Wiśniowski, Elżbieta Kowalska…
    Citation: BMC Cancer 2010 10:420
  22. H. pylori, whose infection increases tumor invasiveness and metastasis, is generally labelled as the strongest risk factor for the development of gastric cancer. It appears not to be a coincidence that there i...

    Authors: Chenghai Zhao, Xiaomei Lu, Xianmin Bu, Ning Zhang and Wei Wang
    Citation: BMC Cancer 2010 10:419
  23. Prostate cancer is a leading cause of cancer-related death in men worldwide. Survivin is a member of the inhibitor of apoptosis (IAP) protein family that is expressed in the majority of human tumors including ...

    Authors: Xichun Liu, Ruijuan Gao, Yan Dong, Lifang Gao, Yanying Zhao, Lijuan Zhao, Xuejian Zhao and Haitao Zhang
    Citation: BMC Cancer 2010 10:418
  24. Radiotherapy for head and neck cancer results in severe and chronic salivary gland dysfunction in most individuals. This results in significant side effects including xerostomia, dysphagia, and malnutrition wh...

    Authors: Oliver Grundmann, Jamia L Fillinger, Kerton R Victory, Randy Burd and Kirsten H Limesand
    Citation: BMC Cancer 2010 10:417
  25. Lymphatic vessel spread is considered a major route for head and neck squamous cell carcinoma metastasis. Formation of new lymphatic vessels could facilitate the process, raising the malignant potential of the...

    Authors: Darío Garcia-Carracedo, Juan Pablo Rodrigo, Aurora Astudillo, Carlos Suarez Nieto and Maria Victoria Gonzalez
    Citation: BMC Cancer 2010 10:416
  26. Our study aims to evaluate the expression of TLR9 in glioma tissues, examine the association between TLR9 expression, clinicopathological variables, and glioma patient outcome, we further characterized the dir...

    Authors: Chao Wang, Shouqiang Cao, Ying Yan, Qiao Ying, Tao Jiang, Ke Xu and Anhua Wu
    Citation: BMC Cancer 2010 10:415
  27. In breast cancer cells, the metastatic cell state is strongly correlated to epithelial-to-mesenchymal transition (EMT) and the CD44+/CD24- stem cell phenotype. However, the MCF-7 cell line, which has a luminal ep...

    Authors: Masahiro Uchino, Hiroko Kojima, Kenta Wada, Mika Imada, Fumitoshi Onoda, Hiroyuki Satofuka, Takahiko Utsugi and Yasufumi Murakami
    Citation: BMC Cancer 2010 10:414
  28. Genetically, colorectal cancers (CRCs) can be subdivided into tumors with chromosomal instability (CIN) or microsatellite instability (MSI). In both types of CRCs genes that are involved in the degradation of ...

    Authors: Silvio K Scheel, Marc Porzner, Sabine Pfeiffer, Steffen Ormanns, Thomas Kirchner and Andreas Jung
    Citation: BMC Cancer 2010 10:413
  29. Breast cancer treatment is based on a combination of adjuvant chemotherapy followed by radiotherapy effecting intracellular signal transduction. With the tyrosine kinase inhibitors new targeted drugs are avail...

    Authors: Marion T Weigel, Linda Dahmke, Christian Schem, Dirk O Bauerschlag, Katrin Weber, Peter Niehoff, Maret Bauer, Alexander Strauss, Walter Jonat, Nicolai Maass and Christoph Mundhenke
    Citation: BMC Cancer 2010 10:412
  30. Breast cancer cells with CD44+/CD24- cell surface marker expression profile are proposed as cancer stem cells (CSCs). Normal breast epithelial cells that are CD44+/CD24- express higher levels of stem/progenito...

    Authors: Poornima Bhat-Nakshatri, Hitesh Appaiah, Christopher Ballas, Patricia Pick-Franke, Robert Goulet Jr, Sunil Badve, Edward F Srour and Harikrishna Nakshatri
    Citation: BMC Cancer 2010 10:411
  31. Studies of several tumour types have shown that expression profiling of cellular protein extracted from surgical tissue specimens by direct mass spectrometry analysis can accurately discriminate tumour from no...

    Authors: Christopher CL Liao, Nicholas Ward, Simon Marsh, Tan Arulampalam and John D Norton
    Citation: BMC Cancer 2010 10:410
  32. Elevated Hsp90 expression has been documented in breast ductal carcinomas, whereas decreased Hsp90 expression has been reported in precursor lobular lesions. This study aims to assess Hsp90 expression in infil...

    Authors: Flora Zagouri, Theodoros Sergentanis, Afrodite Nonni, Christos Papadimitriou, Anastasia Pazaiti, Nikolaos V Michalopoulos, Panagiotis Safioleas, Andreas Lazaris, George Theodoropoulos, Effstratios Patsouris and George Zografos
    Citation: BMC Cancer 2010 10:409
  33. MUTYH-associated polyposis (MAP) is a disorder caused by bi-allelic germline MUTYH mutation, characterized by multiple colorectal adenomas. In order to identify mutations in MUTYH gene we applied High Resolution...

    Authors: Isabel López-Villar, Rosa Ayala, Jan Wesselink, Juan Diego Morillas, Elena López, José Carlos Marín, José Díaz-Tasende, Sara González, Luis Robles and Joaquín Martínez-López
    Citation: BMC Cancer 2010 10:408
  34. Neurofibromatosis type 1 is a common autosomal dominant disorder with full penetrance and variable expression. The condition predisposes individuals to the development of malignant nervous system tumours, most...

    Authors: German Melean, Alba Marina Hernández, María Carmen Valero, Elisabete Hernández-Imaz, Yolanda Martín and Concepción Hernández-Chico
    Citation: BMC Cancer 2010 10:407
  35. Cancer patients may benefit from physical exercise programs. It is unclear, however, how sustained levels of physical activity are best achieved in this population. A systematic review was performed to summari...

    Authors: Ruud H Knols, Eling D de Bruin, Kei Shirato, Daniel Uebelhart and Neil K Aaronson
    Citation: BMC Cancer 2010 10:406
  36. The response to treatment varies among patients with multiple myeloma and markers for prediction of treatment outcome are highly needed. Bioactivation of cyclophosphamide and thalidomide, and biodegradation of...

    Authors: Annette J Vangsted, Karen Søeby, Tobias W Klausen, Niels Abildgaard, Niels F Andersen, Peter Gimsing, Henrik Gregersen, Ulla Vogel, Thomas Werge and Henrik B Rasmussen
    Citation: BMC Cancer 2010 10:404
  37. Siah proteins play an important role in cancer progression. We evaluated the effect of Siah1, its splice variants Siah1L and the Siah1 mutant with the RING finger deleted (Siah1ΔR) on radiosensitization of hum...

    Authors: Hai-Tao He, Emmanouil Fokas, An You, Rita Engenhart-Cabillic and Han-Xiang An
    Citation: BMC Cancer 2010 10:403
  38. Colorectal peritoneal carcinomatosis (CRPC) is a common form of systemic metastasis of intra-abdominal cancers. Intraperitoneal chemotherapy is a preferable option for colorectal cancer. Here we reported that ...

    Authors: Yongsheng Wang, Changyang Gong, Li Yang, Qinjie Wu, Shuai Shi, Huashan Shi, Zhiyong Qian and Yuquan Wei
    Citation: BMC Cancer 2010 10:402
  39. Gene mutation is an important mechanism of myeloid leukemogenesis. However, the number and combination of gene mutated in myeloid malignancies is still a matter of investigation.

    Authors: Julien Rocquain, Nadine Carbuccia, Virginie Trouplin, Stéphane Raynaud, Anne Murati, Meyer Nezri, Zoulika Tadrist, Sylviane Olschwang, Norbert Vey, Daniel Birnbaum, Véronique Gelsi-Boyer and Marie-Joelle Mozziconacci
    Citation: BMC Cancer 2010 10:401
  40. Emerging trends and new policies suggest that more cancer patients might die at home in the future. However, not all have equal chances of achieving this. Furthermore, there is lack of evidence to support that...

    Authors: Barbara Gomes, Paul McCrone, Sue Hall, Jonathan Koffman and Irene J Higginson
    Citation: BMC Cancer 2010 10:400
  41. CpG island methylator phenotype (CIMP), in which multiple genes concordantly methylated, has been demonstrated to be associated with progression, recurrence, as well as overall survival in some types of cancer.

    Authors: Li-Ming Wu, Feng Zhang, Lin Zhou, Zhe Yang, Hai-Yang Xie and Shu-Sen Zheng
    Citation: BMC Cancer 2010 10:399
  42. Vascular endothelial growth factor (VEGF) is a primary stimulant of angiogenesis under physiological and pathological conditions. Anti-VEGF therapy is a clinically proven strategy for the treatment of a variet...

    Authors: Kristi D Lynn, D Gomika Udugamasooriya, Christina L Roland, Diego H Castrillon, Thomas J Kodadek and Rolf A Brekken
    Citation: BMC Cancer 2010 10:397
  43. HER2 gene copy status, and concomitant administration of trastuzumab (Herceptin), remains one of the best examples of targeted cancer therapy based on understanding the genomic etiology of disease. However, newl...

    Authors: Shelly Gunn, I-Tien Yeh, Irina Lytvak, Budi Tirtorahardjo, Natasha Dzidic, Soheila Zadeh, Jaeweon Kim, Chris McCaskill, Lony Lim, Mercedes Gorre and Mansoor Mohammed
    Citation: BMC Cancer 2010 10:396
  44. Mutations of the MEN1 gene predispose to multiple endocrine neoplasia type 1 (MEN1) syndrome. Our group and others have shown that Men1 disruption in mice recapitulates MEN1 pathology. Intriguingly, rare lesions ...

    Authors: Christelle Seigne, Sandra Fontanière, Christine Carreira, Jieli Lu, Wei-Ming Tong, Bernard Fontanière, Zhao-Qi Wang, Chang Xian Zhang and Lucien Frappart
    Citation: BMC Cancer 2010 10:395
  45. NF-κB is a survival signaling transcription factor complex involved in the malignant phenotype of many cancers, including squamous cell carcinomas (SCC). The citrus coumarin, auraptene (AUR), and the ethno-med...

    Authors: Heather E Kleiner-Hancock, Runhua Shi, Angela Remeika, Delira Robbins, Misty Prince, Jennifer N Gill, Zanobia Syed, Patrick Adegboyega, J Michael Mathis and John L Clifford
    Citation: BMC Cancer 2010 10:394
  46. The hTERT (human telomerase reverse transcriptase) gene contains five variable number tandem repeats (VNTR) and previous studies have described polymorphisms for hTERT-VNTR2-2nd. We investigated how allelic varia...

    Authors: Se-Lyun Yoon, Se-Il Jung, Eun-Ju Do, Se-Ra Lee, Sang-Yeop Lee, In-Sun Chu, Wun-Jae Kim, Jaeil Jung, Choung Soo Kim, Sang-Hyeon Cheon and Sun-Hee Leem
    Citation: BMC Cancer 2010 10:393

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