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  1. We conducted a systematic review and meta-analysis to clarify the risk of early and late cardiotoxicity of anthracycline agents in patients treated for breast or ovarian cancer, lymphoma, myeloma or sarcoma.

    Authors: Lesley A Smith, Victoria R Cornelius, Christopher J Plummer, Gill Levitt, Mark Verrill, Peter Canney and Alison Jones
    Citation: BMC Cancer 2010 10:337
  2. Gene expression profiling may improve prognostic accuracy in patients with early breast cancer. Our objective was to demonstrate that it is possible to develop a simple molecular signature to predict distant r...

    Authors: Iker Sánchez-Navarro, Angelo Gámez-Pozo, Álvaro Pinto, David Hardisson, Rosario Madero, Rocío López, Belén San José, Pilar Zamora, Andrés Redondo, Jaime Feliu, Paloma Cejas, Manuel González Barón, Juan Ángel Fresno Vara and Enrique Espinosa
    Citation: BMC Cancer 2010 10:336
  3. MED28 (also known as EG-1 and magicin) has been implicated in transcriptional control, signal regulation, and cell proliferation. MED28 has also been associated with tumor progression in in vitro and in vivo mode...

    Authors: Nam K Yoon, Erin L Maresh, Yahya Elshimali, Ai Li, Steve Horvath, David B Seligson, David Chia and Lee Goodglick
    Citation: BMC Cancer 2010 10:335
  4. Serum CD26 (sCD26) levels were previously found diminished in colorectal cancer (CRC) patients compared to healthy donors, suggesting its potential utility for early diagnosis. Therefore we aimed to estimate t...

    Authors: Loretta De Chiara, Ana M Rodríguez-Piñeiro, Francisco J Rodríguez-Berrocal, Oscar J Cordero, David Martínez-Ares and María Páez de la Cadena
    Citation: BMC Cancer 2010 10:333
  5. Diagnosing colorectal cancer (CRC) at an early stage improves survival. To what extent any delay affects outcome once patients are symptomatic is still unclear.

    Authors: Jochim S Terhaar sive Droste, Frank A Oort, René WM van der Hulst, Veerle MH Coupé, Mike E Craanen, Gerrit A Meijer, Linde M Morsink, Otto Visser, Roy LJ van Wanrooij and Chris JJ Mulder
    Citation: BMC Cancer 2010 10:332
  6. Proteolytic cleavage of the extracellular domain (EpEx) of Epithelial cell adhesion molecule (EpCAM) and nuclear signaling by its intracellular oncogenic domain Ep-ICD has recently been implicated in increased...

    Authors: Ranju Ralhan, Jun Cao, Terence Lim, Christina MacMillan, Jeremy L Freeman and Paul G Walfish
    Citation: BMC Cancer 2010 10:331
  7. The alternatively spliced V region or type III connecting segment III (IIICS) of fibronectin is important in early development, wound healing, and tumorigenesis, however, its role in oral cancer has not been f...

    Authors: Pachiyappan Kamarajan, Angeles Garcia-Pardo, Nisha J D'Silva and Yvonne L Kapila
    Citation: BMC Cancer 2010 10:330
  8. The HMGA2 gene, coding for an architectural transcription factor involved in mesenchymal embryogenesis, is frequently deranged by translocation and/or amplification in mesenchymal tumours, generally leading to...

    Authors: Jørn Henriksen, Marianne Stabell, Leonardo A Meza-Zepeda, Silje AU Lauvrak, Moustapha Kassem and Ola Myklebost
    Citation: BMC Cancer 2010 10:329
  9. There is increasing evidence that the toll-like receptor 3 (TLR3) is an interesting target for anti-cancer therapy. Unfortunately, most laboratory investigations about the impact of TLR3 stimulation on human m...

    Authors: Luc Friboulet, Claire Gourzones, Sai Wah Tsao, Yannis Morel, Carine Paturel, Stéphane Témam, Catherine Uzan and Pierre Busson
    Citation: BMC Cancer 2010 10:327
  10. Several viruses with known oncogenic potential infect prostate tissue, among these are the polyomaviruses BKV, JCV, and SV40; human papillomaviruses (HPVs), and human cytomegalovirus (HCMV) infections. Recentl...

    Authors: Margarita L Martinez-Fierro, Robin J Leach, Lauro S Gomez-Guerra, Raquel Garza-Guajardo, Teresa Johnson-Pais, Joke Beuten, Idelma B Morales-Rodriguez, Mario A Hernandez-Ordoñez, German Calderon-Cardenas, Rocio Ortiz-Lopez, Ana M Rivas-Estilla, Jesus Ancer-Rodriguez and Augusto Rojas-Martinez
    Citation: BMC Cancer 2010 10:326
  11. The importance of cell-surface nucleolin in cancer biology was recently highlighted by studies showing that ligands of nucleolin play critical role in tumorigenesis and angiogenesis. By using a specific antago...

    Authors: Diala El Khoury, Damien Destouches, Renée Lengagne, Bernard Krust, Yamina Hamma-Kourbali, Marylène Garcette, Sandra Niro, Masashi Kato, Jean-Paul Briand, José Courty, Ara G Hovanessian and Armelle Prévost-Blondel
    Citation: BMC Cancer 2010 10:325
  12. Pemphigus vulgaris (PV) is an autoimmune blistering disease of the skin and mucous membranes. Genital involvement occurs when most other common sites are concurrently affected or are in remission. Systemic lup...

    Authors: Giuseppe Bifulco, Vincenzo D Mandato, Roberto Piccoli, Pierluigi Giampaolino, Chiara Mignogna, Michele D Mignogna, Luigi Costagliola and Carmine Nappi
    Citation: BMC Cancer 2010 10:324
  13. The role of TNFα in cancer is complex with both pro-tumourigenic and anti-tumourigenic roles proposed. We hypothesised that anatomical microlocalisation is critical for its function.

    Authors: Chandra M Ohri, Aarti Shikotra, Ruth H Green, David A Waller and Peter Bradding
    Citation: BMC Cancer 2010 10:323
  14. The thymus arises in the ventral portion of the third and fourth pharyngeal pouch. It descends into the anterior mediastinum at 6th week of gestation. Any errors occurring during this process can cause disseminat...

    Authors: Ferdinando Marandino, Carmine Zoccali, Nicola Salducca, Mirella Marino and Paolo Visca
    Citation: BMC Cancer 2010 10:322
  15. The breast is a rare extranodal site of non-Hodgkin lymphoma, and primary breast lymphoma (PBL) has been arbitrarily defined as disease localized to one or both breasts with or without regional lymph nodes inv...

    Authors: Ho-Young Yhim, Hye Jin Kang, Yoon Hee Choi, Seok Jin Kim, Won Seog Kim, Yee Soo Chae, Jin Seok Kim, Chul Won Choi, Sung Yong Oh, Hyeon Seok Eom, Jeong-A Kim, Jae Hoon Lee, Jong-Ho Won, Hyeok Shim, Je-Jung Lee, Hwa Jung Sung…
    Citation: BMC Cancer 2010 10:321
  16. Tumor hypoxia is marked by enhanced expression of hypoxia-inducible factor-α (HIF-1α) and glucose transporter-1 (Glut-1). Hypoxic conditions have also been associated with overexpression of angiogenic factors,...

    Authors: Mariusz Koda, Luiza Kanczuga-Koda, Mariola Sulkowska, Eva Surmacz and Stanislaw Sulkowski
    Citation: BMC Cancer 2010 10:320
  17. We have identified a set of genes whose relative mRNA expression levels in various solid tumors can be used to robustly distinguish cancer from matching normal tissue. Our current feature set consists of 113 g...

    Authors: Joseph Irgon, C Chris Huang, Yi Zhang, Dmitri Talantov, Gyan Bhanot and Sándor Szalma
    Citation: BMC Cancer 2010 10:319
  18. Two mature microRNAs (miRNAs), hsa-miR-125a-3p and hsa-miR-125a-5p (collectively referred to as hsa-miR-125a-3p/5p), are derived from 3' and 5' ends of pre-miR-125a, respectively. Although impaired regulation ...

    Authors: Lili Jiang, Qin Huang, Siyang Zhang, Qingfu Zhang, Jihong Chang, Xueshan Qiu and Enhua Wang
    Citation: BMC Cancer 2010 10:318
  19. The product of CDKN2A, p16 is an essential regulator of the cell cycle controlling the entry into the S-phase. Herein, we evaluated CDKN2A promoter methylation and p16 protein expression for the differentiatio...

    Authors: Antal Csepregi, Matthias PA Ebert, Christoph Röcken, Regine Schneider-Stock, Juliane Hoffmann, Hans-Ulrich Schulz, Albert Roessner and Peter Malfertheiner
    Citation: BMC Cancer 2010 10:317
  20. Reactivation of p53 by either gene transfer or pharmacologic approaches may compensate for loss of p19Arf or excess mdm2 expression, common events in melanoma and glioma. In our previous work, we constructed t...

    Authors: Christian A Merkel, Rafael B da Silva Soares, Anna Carolina V de Carvalho, Daniela B Zanatta, Marcio C Bajgelman, Paula Fratini, Eugenia Costanzi-Strauss and Bryan E Strauss
    Citation: BMC Cancer 2010 10:316
  21. Genome wide association studies (GWAS) have identified several genetic variants that are associated with prostate cancer. Most of these variants, like other GWAS association signals, are located in non-coding ...

    Authors: Lorna W Harries, John RB Perry, Paul McCullagh and Malcolm Crundwell
    Citation: BMC Cancer 2010 10:315
  22. The onset and the development of neoplastic disease may be influenced by many physiological, biological and immunological factors. The nervous, endocrine and immune system might act as an integrated unit to ma...

    Authors: Gianluigi Mazzoccoli, Gianluigi Vendemiale, Angelo De Cata, Stefano Carughi and Roberto Tarquini
    Citation: BMC Cancer 2010 10:314
  23. The cytochrome P450 (CYP) enzymes 2C19, 2D6, and 3A5 are responsible for converting the selective estrogen receptor modulator (SERM), tamoxifen to its active metabolites 4-hydroxy-tamoxifen (4OHtam) and 4-hydr...

    Authors: Jennifer Gjerde, Jürgen Geisler, Steinar Lundgren, Dagfinn Ekse, Jan Erik Varhaug, Gunnar Mellgren, Vidar M Steen and Ernst A Lien
    Citation: BMC Cancer 2010 10:313
  24. Telomerase expression is one of the characteristics of gastric cancer (GC) cells and telomerase activity is frequently up-regulated by a variety of mechanisms during GC development. Therefore, we hypothesized ...

    Authors: Xianli He, Qing Qiao, Naijian Ge, Jing Nan, Shuqun Shen, Zizhong Wang, Yefa Yang and Guoqiang Bao
    Citation: BMC Cancer 2010 10:312
  25. Eradication of early gastric carcinoma (GC) is thought to contribute to reduction in the mortality of GC, given that most of the early GCs progress to the advanced GCs. However, early GC is alternatively consi...

    Authors: Takahisa Nakayama, Zhi-Qiang Ling, Ken-ichi Mukaisho, Takanori Hattori and Hiroyuki Sugihara
    Citation: BMC Cancer 2010 10:311
  26. The incidence of invasive cervical cancer in HIV-positive women is higher than in the general population. There is evidence that HIV-positive women do not participate sufficiently in cervical cancer screening ...

    Authors: Luigino Dal Maso, Silvia Franceschi, Mauro Lise, Priscilla Sassoli de' Bianchi, Jerry Polesel, Florio Ghinelli, Fabio Falcini and Alba C Finarelli
    Citation: BMC Cancer 2010 10:310
  27. The role of peri-operative chemotherapy in patients with resected stage IV colorectal cancer (CRC) remains to be defined. This study was aimed at evaluating the effectiveness of peri-operative chemotherapy in ...

    Authors: Martina Wieser, Stefan Sauerland, Dirk Arnold, Wolff Schmiegel and Anke Reinacher-Schick
    Citation: BMC Cancer 2010 10:309
  28. We conducted a retrospective study in our hospital in which we compared D1 with D3 through D2 lymphadenectomy for gastric cancer in terms of morbidity, postoperative mortality, long-term survival after surgery.

    Authors: Hao Zhang, Caigang Liu, Di Wu, Yi Meng, Ruonan Song, Ping Lu and Shubao Wang
    Citation: BMC Cancer 2010 10:308
  29. Hypoxia inducible factor 1α (HIF-1α) plays an essential role in the adaptive response of cells to hypoxia and is associated with aggressive tumour behaviour. We have shown p27kip1, which is generally reduced in e...

    Authors: Laura MS Seeber, Nicole Horrée, Petra van der Groep, Elsken van der Wall, René HM Verheijen and Paul J van Diest
    Citation: BMC Cancer 2010 10:307
  30. 14-3-3epsilon regulates a wide range of biological processes, including cell cycle control, proliferation, and apoptosis, and plays a significant role in neurogenesis and the formation of malignant tumours. Ho...

    Authors: Xing-Hua Che, Hong Chen, Zhen-Ming Xu, Chao Shang, Kai-Lai Sun and Wei-Neng Fu
    Citation: BMC Cancer 2010 10:306
  31. Health-related quality of life (HRQOL) has been increasingly emphasized in cancer patients. There are no reports comparing baseline HRQOL of different subgroups of glioma patients prior to surgery.

    Authors: Jin-xiang Cheng, Bo-lin Liu, Xiang Zhang, Wei Lin, Yong-qiang Zhang, Wei-ping Liu, Jian-ning Zhang, Hong Lin, Rui Wang and Hong Yin
    Citation: BMC Cancer 2010 10:305
  32. Microsatellite instability (MSI) occurs in 15% of colorectal cancers (CRC). The genetic targets for mutation in the MSI phenotype include somatic mutations in the transforming growth factor beta receptor typeII (...

    Authors: Masakazu Yashiro, Kosei Hirakawa and C Richard Boland
    Citation: BMC Cancer 2010 10:303
  33. Cholangiocarcinoma (CC) is a malignant neoplasm of the bile ducts or the gallbladder. Targeting of growth factor receptors showed therapeutic potential in palliative settings for many solid tumors. The aim of ...

    Authors: Ling Xu, Martin Hausmann, Wolfgang Dietmaier, Silvia Kellermeier, Theresa Pesch, Manuela Stieber-Gunckel, Elisabeth Lippert, Frank Klebl and Gerhard Rogler
    Citation: BMC Cancer 2010 10:302
  34. Numerous factors that contribute to malignant glioma invasion have been identified, but the upstream genes coordinating this process are poorly known.

    Authors: Hong Wei Yang, Lata G Menon, Peter M Black, Rona S Carroll and Mark D Johnson
    Citation: BMC Cancer 2010 10:301
  35. The development and progression of colorectal cancer has been extensively studied and the genes responsible have been well characterized. However the correlation between the SMAD4 gene mutations with KRAS mutant ...

    Authors: A Syed Sameer, Nissar A Chowdri, Nidda Syeed, Mujeeb Z Banday, Zaffar A Shah and Mushtaq A Siddiqi
    Citation: BMC Cancer 2010 10:300
  36. Patients with gastric cancer in China have worse outcome and poorer prognosis. Tumor-induced lymphangiogenesis plays a crucial role in metastasis and tumor progression. The intratumoral and peritumoral lymphat...

    Authors: Xiao-Lei Wang, Jian-Ping Fang, Ru-Yong Tang and Xi-Mei Chen
    Citation: BMC Cancer 2010 10:299
  37. The proto-oncogene Src is an important non-receptor protein tyrosine kinase involved in signaling pathways that control cell adhesion, growth, migration and differentiation. It negatively regulates osteoblast ...

    Authors: Hichame Id Boufker, Laurence Lagneaux, Mehdi Najar, Martine Piccart, Ghanem Ghanem, Jean-Jacques Body and Fabrice Journé
    Citation: BMC Cancer 2010 10:298
  38. The aim of the current study was to analyze the involvement of methyl-CpG binding proteins (MBDs) and histone modifications on the regulation of CD44, Cyclin D2, GLIPR1 and PTEN in different cellular contexts ...

    Authors: Imke Müller, Frank Wischnewski, Klaus Pantel and Heidi Schwarzenbach
    Citation: BMC Cancer 2010 10:297
  39. Previous studies have shown that the ADIPOR1, ADORA1, BTG2 and CD46 genes differ significantly between long-term survivors of breast cancer and deceased patients, both in levels of gene expression and DNA copy nu...

    Authors: Elin Möllerström, Anikó Kovács, Kristina Lövgren, Szilard Nemes, Ulla Delle, Anna Danielsson, Toshima Parris, Donal J Brennan, Karin Jirström, Per Karlsson and Khalil Helou
    Citation: BMC Cancer 2010 10:296
  40. Pancreatic cancer is still associated with devastating prognosis. Real progress in treatment options has still not been achieved. Therefore new models are urgently needed to investigate this deadly disease. As...

    Authors: Tatyana Kalinina, Cenap Güngör, Sabrina Thieltges, Maren Möller-Krull, Eva Maria Murga Penas, Daniel Wicklein, Thomas Streichert, Udo Schumacher, Viacheslav Kalinin, Ronald Simon, Benjamin Otto, Judith Dierlamm, Heidi Schwarzenbach, Katharina E Effenberger, Maximilian Bockhorn, Jakob R Izbicki…
    Citation: BMC Cancer 2010 10:295
  41. Metastasis is a multi-step process that is responsible for the majority of deaths in cancer patients. Current treatments are not effective in targeting metastasis. The molecular chaperone hsp90α is secreted fr...

    Authors: Jessica McCready, Jessica D Sims, Doug Chan and Daniel G Jay
    Citation: BMC Cancer 2010 10:294
  42. Increasing evidence has underscored the role of carcinoma associated fibroblasts (CAF) in tumor growth. However, there are controversial data regarding the persistence of inoculated CAF within the tumors. We h...

    Authors: Victoria T Fabris, Ana Sahores, Silvia I Vanzulli, Lucas Colombo, Alfredo A Molinolo, Claudia Lanari and Caroline A Lamb
    Citation: BMC Cancer 2010 10:293
  43. Chronic gastro-oesophageal reflux disease and excessive body fat are considered principal causes of Barrett's oesophagus (a metaplastic change in the cells lining the oesophagus) and its neoplastic progression...

    Authors: Brooke M Winzer, Jennifer D Paratz, Marina M Reeves and David C Whiteman
    Citation: BMC Cancer 2010 10:292
  44. Molecularly targeted drugs inhibit aberrant signaling within oncogenic pathways. Identifying the predominant pathways at work within a tumor is a key step towards tailoring therapies to the patient. Clinical s...

    Authors: Yogesh M Kulkarni, Vivian Suarez and David J Klinke II
    Citation: BMC Cancer 2010 10:291
  45. Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies. Early diagnosis is critical for guiding the therapeutic management of ESCC. It is imperative to find more effective biomarkers ...

    Authors: Xi Zhu, Ming Ding, Mei-Lan Yu, Ming-Xiang Feng, Li-Jie Tan and Fu-Kun Zhao
    Citation: BMC Cancer 2010 10:290
  46. Diabetes is associated with an increased risk of several malignancies. Both diabetic patients and patients with cancer have an increase in platelet reactivity and platelet activation has recently emerged as a ...

    Authors: Chris E Holmes, Maria E Ramos-Nino and Benjamin Littenberg
    Citation: BMC Cancer 2010 10:289
  47. Decreased expression of the angiogenesis inhibitor ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif, 1) has previously been reported during prostate cancer progression. The aim of this study was...

    Authors: Heléne Gustavsson, Tajana Tešan, Karin Jennbacken, Kouji Kuno, Jan-Erik Damber and Karin Welén
    Citation: BMC Cancer 2010 10:288

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