Cunningham D, Atkin W, Lenz HJ, Lynch HT, Minsky B, Nordlinger B: Colorectal cancer. Lancet. 2010, 375: 1030-1047. 10.1016/S0140-6736(10)60353-4.
Article
PubMed
Google Scholar
Tol J, Punt CJ: Monoclonal antibodies in the treatment of metastatic colorectal cancer: a review. Clin Ther. 2010, 32: 437-453. 10.1016/j.clinthera.2010.03.012.
Article
CAS
PubMed
Google Scholar
Karapetis CS, Khambata-Ford S, Jonker DJ, O’Callaghan CJ, Tu D, Tebbutt NC: K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med. 2008, 359: 1757-1765. 10.1056/NEJMoa0804385.
Article
CAS
PubMed
Google Scholar
Lievre A, Bachet JB, Boige V, Cayre A, Le CD, Buc E: KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol. 2008, 26: 374-379. 10.1200/JCO.2007.12.5906.
Article
CAS
PubMed
Google Scholar
Tveit KM, Guren T, Glimelius B, Pfeiffer P, Sorbye H, Pyrhonen S: Phase III trial of cetuximab with continuous or intermittent fluorouracil, leucovorin, and oxaliplatin (Nordic FLOX) versus FLOX alone in first-line treatment of metastatic colorectal cancer: the NORDIC-VII study. J Clin Oncol. 2012, 30: 1755-1762. 10.1200/JCO.2011.38.0915.
Article
CAS
PubMed
Google Scholar
Maughan TS, Adams RA, Smith CG, Meade AM, Seymour MT, Wilson RH: Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet. 2011, 377: 2103-2114. 10.1016/S0140-6736(11)60613-2.
Article
CAS
PubMed
PubMed Central
Google Scholar
Primrose JN, Falk S, Finch-Jones M, Valle JW, Sherlock D, Hornbuckle J: A randomized clinical trial of chemotherapy compared to chemotherapy in combination with cetuximab in k-RAS wild-type patients with operable metastases from colorectal cancer: the new EPOC study. ASCO Meeting Abstracts. 2013, 31: 3504-
Google Scholar
Kurai J, Chikumi H, Hashimoto K, Yamaguchi K, Yamasaki A, Sako T: Antibody-dependent cellular cytotoxicity mediated by cetuximab against lung cancer cell lines. Clin Cancer Res. 2007, 13: 1552-1561. 10.1158/1078-0432.CCR-06-1726.
Article
CAS
PubMed
Google Scholar
Desjarlais JR, Lazar GA, Zhukovsky EA, Chu SY: Optimizing engagement of the immune system by anti-tumor antibodies: an engineer’s perspective. Drug Discov Today. 2007, 12: 898-910. 10.1016/j.drudis.2007.08.009.
Article
CAS
PubMed
Google Scholar
van Sorge NM, van der Pol WL, van de Winkel JG: FcgammaR polymorphisms: Implications for function, disease susceptibility and immunotherapy. Tissue Antigens. 2003, 61: 189-202. 10.1034/j.1399-0039.2003.00037.x.
Article
CAS
PubMed
Google Scholar
Weng WK, Levy R: Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma. J Clin Oncol. 2003, 21: 3940-3947. 10.1200/JCO.2003.05.013.
Article
CAS
PubMed
Google Scholar
Cartron G, Dacheux L, Salles G, Solal-Celigny P, Bardos P, Colombat P: Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene. Blood. 2002, 99: 754-758. 10.1182/blood.V99.3.754.
Article
CAS
PubMed
Google Scholar
Musolino A, Naldi N, Bortesi B, Pezzuolo D, Capelletti M, Missale G: Immunoglobulin G fragment C receptor polymorphisms and clinical efficacy of trastuzumab-based therapy in patients with HER-2/neu-positive metastatic breast cancer. J Clin Oncol. 2008, 26: 1789-1796. 10.1200/JCO.2007.14.8957.
Article
CAS
PubMed
Google Scholar
Tamura K, Shimizu C, Hojo T, Kashi-Tanaka S, Kinoshita T, Yonemori K: FcgammaR2A and 3A polymorphisms predict clinical outcome of trastuzumab in both neoadjuvant and metastatic settings in patients with HER2-positive breast cancer. Ann Oncol. 2011, 22: 1302-1307. 10.1093/annonc/mdq585.
Article
CAS
PubMed
Google Scholar
Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L: New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst. 2000, 92: 205-216. 10.1093/jnci/92.3.205.
Article
CAS
PubMed
Google Scholar
Douillard JY, Oliner KS, Siena S, Tabernero J, Burkes RF, Barugel MF: Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N Engl J Med. 2013, 369: 1023-1034. 10.1056/NEJMoa1305275.
Article
CAS
PubMed
Google Scholar
Seymour MT, Brown SR, Middleton G, Maughan TF, Richman S, Gwyther S, Lowe C: Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial. Lancet Oncol. 2013, 14: 749-759. 10.1016/S1470-2045(13)70163-3.
Article
CAS
PubMed
PubMed Central
Google Scholar
De RW, Claes B, Bernasconi D, De SJ, Biesmans B, Fountzilas G: Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol. 2010, 11: 753-762. 10.1016/S1470-2045(10)70130-3.
Article
Google Scholar
Rodriguez S, Gaunt TR, Day IN: Hardy-Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies. Am J Epidemiol. 2009, 169: 505-514.
Article
PubMed
PubMed Central
Google Scholar
Paez D, Pare L, Espinosa I, Salazar J, Del RE, Barnadas A: Immunoglobulin G fragment C receptor polymorphisms and KRAS mutations: are they useful biomarkers of clinical outcome in advanced colorectal cancer treated with anti-EGFR-based therapy?. Cancer Sci. 2010, 101: 2048-2053. 10.1111/j.1349-7006.2010.01621.x.
Article
CAS
PubMed
Google Scholar
Zhang W, Yang D, Harbison C, Khambata-Ford S, Malone DP, Ning Y: FCGR2A H131R and FCGR3A V158F polymorphism status in mCRC patients treated with single-agent cetuximab (IMCL 0144 and CA225045) or with second-line irinotecan plus cetuximab (EPIC): a pooled statistical analysis. ASCO Meeting Abstracts. 2011, 29: e14025-
Google Scholar
Negri FV, Musolino A, Naldi N, Bortesi B, Missale G, Laccabue D: Role of immunoglobulin G fragment C receptor polymorphism-mediated antibody-dependant cellular cytotoxicity in colorectal cancer treated with cetuximab therapy. Pharmacogenomics J. 2013, 14: 14-19.
Article
PubMed
Google Scholar
Bibeau F, Lopez-Crapez E, Di FF, Thezenas S, Ychou M, Blanchard F: Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan. J Clin Oncol. 2009, 27: 1122-1129. 10.1200/JCO.2008.18.0463.
Article
CAS
PubMed
Google Scholar
Rodriguez J, Zarate R, Bandres E, Boni V, Hernandez A, Sola JJ: Fc gamma receptor polymorphisms as predictive markers of Cetuximab efficacy in epidermal growth factor receptor downstream-mutated metastatic colorectal cancer. Eur J Cancer. 2012, 48: 1774-1780. 10.1016/j.ejca.2012.01.007.
Article
CAS
PubMed
Google Scholar
Etienne-Grimaldi MC, Bennouna J, Formento JL, Douillard JY, Francoual M, Hennebelle I: Multifactorial pharmacogenetic analysis in colorectal cancer patients receiving 5-fluorouracil-based therapy together with cetuximab-irinotecan. Br J Clin Pharmacol. 2012, 73: 776-785. 10.1111/j.1365-2125.2011.04141.x.
Article
CAS
PubMed
Google Scholar
Calemma R, Ottaiano A, Trotta AM, Nasti G, Romano C, Napolitano M: Fc gamma receptor IIIa polymorphisms in advanced colorectal cancer patients correlated with response to anti-EGFR antibodies and clinical outcome. J Transl Med. 2012, 10: 232-10.1186/1479-5876-10-232.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhang W, Azuma M, Lurje G, Gordon MA, Yang D, Pohl A: Molecular predictors of combination targeted therapies (cetuximab, bevacizumab) in irinotecan-refractory colorectal cancer (BOND-2 study). Anticancer Res. 2010, 30: 4209-4217.
CAS
PubMed
Google Scholar
Dahan L, Norguet E, Etienne-Grimaldi MC, Formento JL, Gasmi M, Nanni I: Pharmacogenetic profiling and cetuximab outcome in patients with advanced colorectal cancer. BMC Cancer. 2011, 11: 496-10.1186/1471-2407-11-496.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pander J, Gelderblom H, Antonini NF, Tol J, van Krieken JH, van der ST: Correlation of FCGR3A and EGFR germline polymorphisms with the efficacy of cetuximab in KRAS wild-type metastatic colorectal cancer. Eur J Cancer. 2010, 46: 1829-1834. 10.1016/j.ejca.2010.03.017.
Article
CAS
PubMed
Google Scholar
Zhang W, Gordon M, Schultheis AM, Yang DY, Nagashima F, Azuma M: FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab. J Clin Oncol. 2007, 25: 3712-3718. 10.1200/JCO.2006.08.8021.
Article
CAS
PubMed
Google Scholar
Lurje G, Nagashima F, Zhang W, Yang D, Chang HM, Gordon MA: Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab. Clin Cancer Res. 2008, 14: 7884-7895. 10.1158/1078-0432.CCR-07-5165.
Article
CAS
PubMed
Google Scholar
Graziano F, Ruzzo A, Loupakis F, Canestrari E, Santini D, Catalano V: Pharmacogenetic profiling for cetuximab plus irinotecan therapy in patients with refractory advanced colorectal cancer. J Clin Oncol. 2008, 26: 1427-1434. 10.1200/JCO.2007.12.4602.
Article
CAS
PubMed
Google Scholar
Park SJ, Hong YS, Lee JL, Ryu MH, Chang HM, Kim KP: Genetic polymorphisms of FcgammaRIIa and FcgammaRIIIa are not predictive of clinical outcomes after cetuximab plus irinotecan chemotherapy in patients with metastatic colorectal cancer. Oncology. 2012, 82: 83-89. 10.1159/000335959.
Article
CAS
PubMed
Google Scholar
Geva R, Jensen BV, Fountzilas G, Yoshino T, Paez D, Montagut C: An international consortium study in chemorefractory metastatic colorectal cancer (mCRC) patients (pts) to assess the impact of FCGR polymorphisms on cetuximab efficacy. ASCO Meeting Abstracts. 2011, 29: 3528-
Google Scholar
Correale P, Marra M, Remondo C, Migali C, Misso G, Arcuri FP: Cytotoxic drugs up-regulate epidermal growth factor receptor (EGFR) expression in colon cancer cells and enhance their susceptibility to EGFR-targeted antibody-dependent cell-mediated-cytotoxicity (ADCC). Eur J Cancer. 2010, 46: 1703-1711. 10.1016/j.ejca.2010.03.005.
Article
CAS
PubMed
Google Scholar
Schlaeth M, Berger S, Derer S, Klausz K, Lohse S, Dechant M: Fc-engineered EGF-R antibodies mediate improved antibody-dependent cellular cytotoxicity (ADCC) against KRAS-mutated tumor cells. Cancer Sci. 2010, 101: 1080-1088. 10.1111/j.1349-7006.2010.01505.x.
Article
CAS
PubMed
Google Scholar
Clynes RA, Towers TL, Presta LG, Ravetch JV: Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat Med. 2000, 6: 443-446. 10.1038/74704.
Article
CAS
PubMed
Google Scholar
Kono K, Takahashi A, Ichihara F, Sugai H, Fujii H, Matsumoto Y: Impaired antibody-dependent cellular cytotoxicity mediated by herceptin in patients with gastric cancer. Cancer Res. 2002, 62: 5813-5817.
CAS
PubMed
Google Scholar
de Souza AP, Bonorino C: Tumor immunosuppressive environment: effects on tumor-specific and nontumor antigen immune responses. Expert Rev Anticancer Ther. 2009, 9: 1317-1332. 10.1586/era.09.88.
Article
CAS
PubMed
Google Scholar