Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D: Global cancer statistics. CA Cancer J Clin. 2011, 61: 69-90.
Article
PubMed
Google Scholar
Aune D, Greenwood DC, Chan DS, Vieira R, Vieira AR, Navarro RDA, Cade JE, Burley VJ, Norat T: Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose-response meta-analysis of prospective studies. Ann Oncol. 2012, 23: 843-852.
Article
CAS
PubMed
Google Scholar
Moretta L, Moretta A: Unravelling natural killer cell function: triggering and inhibitory human NK receptors. EMBO J. 2004, 23: 255-259.
Article
CAS
PubMed
Google Scholar
Somanchi SS, Somanchi A, Cooper LJ, Lee DA: Engineering lymph node homing of ex vivo-expanded human natural killer cells via trogocytosis of the chemokine receptor CCR7. Blood. 2012, 119: 5164-5172.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kato N, Tanaka J, Sugita J, Toubai T, Miura Y, Ibata M, Syono Y, Ota S, Kondo T, Asaka M, Imamura M: Regulation of the expression of MHC class I-related chain A, B (MICA, MICB) via chromatin remodeling and its impact on the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells. Leukemia. 2007, 21: 2103-2108.
Article
CAS
PubMed
Google Scholar
Balsamo M, Vermi W, Parodi M, Pietra G, Manzini C, Queirolo P, Lonardi S, Augugliaro R, Moretta A, Facchetti F, Moretta L, Mingari MC, Vitale M: Melanoma cells become resistant to NK-cell-mediated killing when exposed to NK-cell numbers compatible with NK-cell infiltration in the tumor. Eur J Immunol. 2012, 42: 1833-1842.
Article
CAS
PubMed
Google Scholar
Siemens DR, Hu N, Sheikhi AK, Chung E, Frederiksen LJ, Pross H, Graham CH: Hypoxia increases tumor cell shedding of MHC class I chain-related molecule: role of nitric oxide. Cancer Res. 2008, 68: 4746-4753.
Article
CAS
PubMed
Google Scholar
Blaheta RA, Cinatl J: Anti-tumor mechanisms of valproate: a novel role for an old drug. Med Res Rev. 2002, 22: 492-511.
Article
CAS
PubMed
Google Scholar
Gottlicher M, Minucci S, Zhu P, Kramer OH, Schimpf A, Giavara S, Sleeman JP, Lo CF, Nervi C, Pelicci PG, Heinzel T: Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J. 2001, 20: 6969-6978.
Article
CAS
PubMed
PubMed Central
Google Scholar
Das CM, Aguilera D, Vasquez H, Prasad P, Zhang M, Wolff JE, Gopalakrishnan V: Valproic acid induces p21 and topoisomerase-II (alpha/beta) expression and synergistically enhances etoposide cytotoxicity in human glioblastoma cell lines. J Neurooncol. 2007, 85: 159-170.
Article
CAS
PubMed
Google Scholar
Blaheta RA, Michaelis M, Natsheh I, Hasenberg C, Weich E, Relja B, Jonas D, Doerr HW, Cinatl J: Valproic acid inhibits adhesion of vincristine- and cisplatin-resistant neuroblastoma tumour cells to endothelium. Br J Cancer. 2007, 96: 1699-1706.
Article
CAS
PubMed
PubMed Central
Google Scholar
Marchion DC, Bicaku E, Daud AI, Sullivan DM, Munster PN: In vivo synergy between topoisomerase II and histone deacetylase inhibitors: predictive correlates. Mol Cancer Ther. 2005, 4: 1993-2000.
Article
CAS
PubMed
Google Scholar
Huang X, Guo B: Adenomatous polyposis coli determines sensitivity to histone deacetylase inhibitor-induced apoptosis in colon cancer cells. Cancer Res. 2006, 66: 9245-9251.
Article
CAS
PubMed
Google Scholar
Schuchmann M, Schulze-Bergkamen H, Fleischer B, Schattenberg JM, Siebler J, Weinmann A, Teufel A, Worns M, Fischer T, Strand S, Lohse AW, Galle PR: Histone deacetylase inhibition by valproic acid down-regulates c-FLIP/CASH and sensitizes hepatoma cells towards CD95- and TRAIL receptor-mediated apoptosis and chemotherapy. Oncol Rep. 2006, 15: 227-230.
CAS
PubMed
Google Scholar
Lu X, Ohata K, Kondo Y, Espinoza JL, Qi Z, Nakao S: Hydroxyurea upregulates NKG2D ligand expression in myeloid leukemia cells synergistically with valproic acid and potentially enhances susceptibility of leukemic cells to natural killer cell-mediated cytolysis. Cancer Sci. 2010, 101: 609-615.
Article
CAS
PubMed
Google Scholar
Poggi A, Catellani S, Garuti A, Pierri I, Gobbi M, Zocchi MR: Effective in vivo induction of NKG2D ligands in acute myeloid leukaemias byall-trans-retinoic acid or sodium valproate. Leukemia. 2009, 23: 641-648.
Article
CAS
PubMed
Google Scholar
Wu X, Tao Y, Hou J, Meng X, Shi J: Valproic Acid Upregulates NKG2D Ligand Expression through an ERK-dependent Mechanism and Potentially Enhances NK Cellmediated Lysis of Myeloma. Neoplasia. 2012, 14: 1178-1189.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zwirner NW, Fuertes MB, Girart MV, Domaica CI, Rossi LE: Cytokine-driven regulation of NK cell functions in tumor immunity: role of the MICA-NKG2D system. Cytokine Growth Factor Rev. 2007, 18: 159-170.
Article
CAS
PubMed
Google Scholar
Armeanu S, Bitzer M, Lauer UM, Venturelli S, Pathil A, Krusch M, Kaiser S, Jobst J, Smirnow I, Wagner A, Steinle A, Salih HR: Natural killer cell-mediated lysis of hepatoma cells via specific induction ofNKG2D ligands by the histone deacetylase inhibitor sodium valproate. Cancer Res. 2005, 65: 6321-6329.
Article
CAS
PubMed
Google Scholar
Song DG, Ye Q, Santoro S, Fang C, Best A, Powell DJ: Chimeric NKG2D CARexpressing T cell-mediated attack of human ovarian cancer isenhanced by histone deacetylase inhibition. Hum Gene Ther. 2013, 24: 295-305.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li P, Morris DL, Willcox BE, Steinle A, Spies T, Strong RK: Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA. Nat Immunol. 2001, 2: 443-451.
CAS
PubMed
Google Scholar
Lu J, Aggarwal R, Kanji S, Das M, Joseph M, Pompili V, Das H: Human ovarian tumor cells escape gammadelta T cell recognition partly by downregulating surface expression of MICA and limiting cell cycle related molecules. PLoS One. 2011, 6: e23348-
Article
CAS
PubMed
PubMed Central
Google Scholar
Okita R, Mougiakakos D, Ando T, Mao Y, Sarhan D, Wennerberg E, Seliger B, Lundqvist A, Mimura K, Kiessling R: HER2/HER3 signaling regulates NK cell mediated cytotoxicity via MHC Class IChain-Related Molecule A and B expression in human breast cancer cell lines. J Immunol. 2012, 188: 2136-2145.
Article
CAS
PubMed
Google Scholar
Tang KF, Ren H, Cao J, Zeng GL, Xie J, Chen M, Wang L, He CX: Decreased Dicer expression elicits DNA damage and up-regulation of MICA and MICB. J Cell Biol. 2008, 182: 233-239.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fritsche P, Seidler B, Schuler S, Schnieke A, Gottlicher M, Schmid RM, Saur D, Schneider G: HDAC2 mediates therapeutic resistance of pancreatic cancer cells via the BH3-onlyprotein NOXA. Gut. 2009, 58: 1399-1409.
Article
CAS
PubMed
Google Scholar
Goodyear O, Agathanggelou A, Novitzky-Basso I, Siddique S, McSkeane T, Ryan G, Vyas P, Cavenagh J, Stankovic T, Moss P, Craddock C: Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloidleukemia and myelodysplasia. Blood. 2010, 116: 1908-1918.
Article
CAS
PubMed
Google Scholar
Hecker RM, Amstutz RA, Wachtel M, Walter D, Niggli FK, Schafer BW: p21 Downregulation is an important component of PAX3/FKHR oncogenicity and itsreactivation by HDAC inhibitors enhances combination treatment. Oncogene. 2010, 29: 3942-3952.
Article
CAS
PubMed
Google Scholar
Duan X, Deng L, Chen X, Lu Y, Zhang Q, Zhang K, Hu Y, Zeng J, Sun W: Clinical significance of the immunostimulatory MHC class I chain-related molecule A and NKG2D receptor on NK cells in pancreatic cancer. Med Oncol. 2011, 28: 466-474.
Article
CAS
PubMed
Google Scholar
Cerboni C, Zingoni A, Cippitelli M, Piccoli M, Frati L, Santoni A: Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATRdependent mechanism and become susceptible to autologous NK- cell lysis. Blood. 2007, 110: 606-615.
Article
CAS
PubMed
Google Scholar
Gasser S, Orsulic S, Brown EJ, Raulet DH: The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature. 2005, 436: 1186-1190.
Article
CAS
PubMed
PubMed Central
Google Scholar
Eisele G, Wischhusen J, Mittelbronn M, Meyermann R, Waldhauer I, Steinle A, Weller M, Friese MA: TGF-beta and metalloproteinases differentially suppress NKG2D ligand surfaceexpression on malignant glioma cells. Brain. 2006, 129: 2416-2425.
Article
PubMed
Google Scholar
Bader AG, Kang S, Zhao L, Vogt PK: Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer. 2005, 5: 921-929.
Article
CAS
PubMed
Google Scholar
Gregory CW, Whang YE, McCall W, Fei X, Liu Y, Ponguta LA, French FS, Wilson EM, Earp HS: Heregulin-induced activation of HER2 and HER3 increases androgen receptor transactivation and CWR-R1 human recurrent prostate cancer cell growth. Clin Cancer Res. 2005, 11: 1704-1712.
Article
CAS
PubMed
Google Scholar
Soriani A, Zingoni A, Cerboni C, Iannitto ML, Ricciardi MR, Di GV, Cippitelli M, Fionda C, Petrucci MT, Guarini A, Foà R, Santoni A: ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype. Blood. 2009, 113: 3503-3511.
Article
CAS
PubMed
Google Scholar
Engelman JA: Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer. 2009, 9: 550-562.
Article
CAS
PubMed
Google Scholar
Gao N, Cheng S, Budhraja A, Liu EH, Chen J, Chen D, Yang Z, Luo J, Shi X, Zhang Z: 3,3′-Diindolylmethane exhibits antileukemic activity in vitro and in vivo through a Aktdependent process. PLoS One. 2012, 7: e31783-
Article
CAS
PubMed
PubMed Central
Google Scholar
Miyoshi S, Hamada H, Hamaguchi N, Kato A, Katayama H, Irifune K, Ito R, Miyazaki T, Okura T, Higaki J: Antitumor activity of MEK and PI3K inhibitors against malignant pleural mesothelioma cells in vitro and in vivo. Int J Oncol. 2012, 41: 449-456.
CAS
PubMed
PubMed Central
Google Scholar
Wang YL, Zhu BJ, Qi ZZ, Wang HJ, Zhou XD: Akt1 Enhances CA916798 Expression through mTOR Pathway. PLoS One. 2013, 8: e62327-
Article
CAS
PubMed
PubMed Central
Google Scholar
Li J, Liang X, Yang X: Ursolic acid inhibits growth and induces apoptosis in gemcitabine-resistant human pancreatic cancer via the JNK and PI3K/Akt/NF-kappaB pathways. Oncol Rep. 2012, 28: 501-510.
CAS
PubMed
Google Scholar
Kimple RJ, Vaseva AV, Cox AD, Baerman KM, Calvo BF, Tepper JE, Shields JM, Sartor CI: Radiosensitization of epidermal growth factor receptor/HER2-positive pancreatic cancer is mediated by inhibition of Akt independent of ras mutational status. Clin Cancer Res. 2010, 16: 912-923.
Article
CAS
PubMed
PubMed Central
Google Scholar