Jemal A, Siegel R, Xu J, Ward E: Cancer statistics, 2010. CA Cancer J Clin. 2010, 60 (5): 277-300. 10.3322/caac.20073.
Article
PubMed
Google Scholar
Carney DN: Lung cancer–time to move on from chemotherapy. N Engl J Med. 2002, 346 (2): 126-128. 10.1056/NEJM200201103460211.
Article
PubMed
Google Scholar
Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, Naoki K, Sasaki H, Fujii Y, Eck MJ, Sellers WR, Johnson BE, Meyerson M: EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004, 304 (5676): 1497-1500. 10.1126/science.1099314.
Article
CAS
PubMed
Google Scholar
Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, Louis DN, Christiani DC, Settleman J, Haber DA: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004, 350 (21): 2129-2139. 10.1056/NEJMoa040938.
Article
CAS
PubMed
Google Scholar
Sasaki H, Endo K, Konishi A, Takada M, Kawahara M, Iuchi K, Matsumura A, Okumura M, Tanaka H, Kawaguchi T, Shimizu T, Takeuchi H, Yano M, Fukai I, Fujii Y: EGFR Mutation status in Japanese lung cancer patients: genotyping analysis using LightCycler. Clin Cancer Res. 2005, 11 (8): 2924-2929. 10.1158/1078-0432.CCR-04-1904.
Article
CAS
PubMed
Google Scholar
Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, Kris MG, Varmus H: Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2005, 2 (3): e73-10.1371/journal.pmed.0020073.
Article
PubMed
PubMed Central
Google Scholar
Shigematsu H, Lin L, Takahashi T, Nomura M, Suzuki M, Wistuba II, Fong KM, Lee H, Toyooka S, Shimizu N, Fujisawa T, Feng Z, Roth JA, Herz J, Minna JD, Gazdar AF: Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst. 2005, 97 (5): 339-346. 10.1093/jnci/dji055.
Article
CAS
PubMed
Google Scholar
Siegel R, Naishadham D, Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 2013, 63 (1): 11-30. 10.3322/caac.21166.
Article
PubMed
Google Scholar
Sasaki T, Rodig SJ, Chirieac LR, Janne PA: The biology and treatment of EML4-ALK non-small cell lung cancer. Eur J Cancer. 2010, 46 (10): 1773-1780. 10.1016/j.ejca.2010.04.002.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hammerman PS, Janne PA, Johnson BE: Resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Clin Cancer Res. 2009, 15 (24): 7502-7509. 10.1158/1078-0432.CCR-09-0189.
Article
CAS
PubMed
Google Scholar
Shaw AT, Yeap BY, Mino-Kenudson M, Digumarthy SR, Costa DB, Heist RS, Solomon B, Stubbs H, Admane S, McDermott U, Settleman J, Kobayashi S, Mark EJ, Rodig SJ, Chirieac LR, Kwak EL, Lynch TJ, Iafrate AJ: Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol. 2009, 27 (26): 4247-4253. 10.1200/JCO.2009.22.6993.
Article
CAS
PubMed
PubMed Central
Google Scholar
Vogel W, Gish GD, Alves F, Pawson T: The discoidin domain receptor tyrosine kinases are activated by collagen. Mol Cell. 1997, 1 (1): 13-23. 10.1016/S1097-2765(00)80003-9.
Article
CAS
PubMed
Google Scholar
Labrador JP, Azcoitia V, Tuckermann J, Lin C, Olaso E, Manes S, Bruckner K, Goergen JL, Lemke G, Yancopoulos G, Angel P, Martínez C, Klein R: The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. EMBO Rep. 2001, 2 (5): 446-452. 10.1093/embo-reports/kve094.
Article
CAS
PubMed
PubMed Central
Google Scholar
Walsh LA, Nawshad A, Medici D: Discoidin domain receptor 2 is a critical regulator of epithelial-mesenchymal transition. Matrix Biol. 2011, 30 (4): 243-247. 10.1016/j.matbio.2011.03.007.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhang K, Corsa CA, Ponik SM, Prior JL, Piwnica-Worms D, Eliceiri KW, Keely PJ, Longmore GD: The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis. Nat Cell Biol. 2013, 15 (6): 677-687. 10.1038/ncb2743.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ren T, Zhang J, Liu X, Yao L: Increased expression of discoidin domain receptor 2 (DDR2): a novel independent prognostic marker of worse outcome in breast cancer patients. Med Oncol. 2013, 30 (1): 397-
Article
PubMed
Google Scholar
Sasaki H, Shitara M, Yokota K, Okuda K, Hikosaka Y, Moriyama S, Yano M, Fujii Y: DDR2 polymorphisms and mRNA expression in lung cancers of Japanese patients. Oncol Lett. 2012, 4 (1): 33-37.
CAS
PubMed
PubMed Central
Google Scholar
Hammerman PS, Sos ML, Ramos AH, Xu C, Dutt A, Zhou W, Brace LE, Woods BA, Lin W, Zhang J, Deng X, Lim SM, Heynck S, Peifer M, Simard JR, Lawrence MS, Onofrio RC, Salvesen HB, Seidel D, Zander T, Heuckmann JM, Soltermann A, Moch H, Koker M, Leenders F, Gabler F, Querings S, Ansén S, Brambilla E, Brambilla C, et al: Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Cancer Discov. 2011, 1 (1): 78-89. 10.1158/2159-8274.CD-11-0005.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ford CE, Lau SK, Zhu CQ, Andersson T, Tsao MS, Vogel WF: Expression and mutation analysis of the discoidin domain receptors 1 and 2 in non-small cell lung carcinoma. Br J Cancer. 2007, 96 (5): 808-814. 10.1038/sj.bjc.6603614.
Article
CAS
PubMed
PubMed Central
Google Scholar
Thiery JP, Acloque H, Huang RY, Nieto MA: Epithelial-mesenchymal transitions in development and disease. Cell. 2009, 139 (5): 871-890. 10.1016/j.cell.2009.11.007.
Article
CAS
PubMed
Google Scholar
Shintani Y, Maeda M, Chaika N, Johnson KR, Wheelock MJ: Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor-beta signaling. Am J Respir Cell Mol Biol. 2008, 38 (1): 95-104. 10.1165/rcmb.2007-0071OC.
Article
CAS
PubMed
Google Scholar
Rosell R, Moran T, Queralt C, Porta R, Cardenal F, Camps C, Majem M, Lopez-Vivanco G, Isla D, Provencio M, Insa A, Massuti B, Gonzalez-Larriba JL, Paz-Ares L, Bover I, Garcia-Campelo R, Moreno MA, Catot S, Rolfo C, Reguart N, Palmero R, Sánchez JM, Bastus R, Mayo C, Bertran-Alamillo J, Molina MA, Sanchez JJ, Taron M: Spanish lung cancer group: screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med. 2009, 361 (10): 958-967. 10.1056/NEJMoa0904554.
Article
CAS
PubMed
Google Scholar
Mok TS, Wu YL, Thongprasert S, Yang CH, Chu DT, Saijo N, Sunpaweravong P, Han B, Margono B, Ichinose Y, Nishiwaki Y, Ohe Y, Yang JJ, Chewaskulyong B, Jiang H, Duffield EL, Watkins CL, Armour AA, Fukuoka M: Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med. 2009, 361 (10): 947-957. 10.1056/NEJMoa0810699.
Article
CAS
PubMed
Google Scholar
Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG, Kim SY, Wardwell L, Tamayo P, Gat-Viks I, Ramos AH, Woo MS, Weir BA, Getz G, Beroukhim R, O’Kelly M, Dutt A, Rozenblatt-Rosen O, Dziunycz P, Komisarof J, Chirieac LR, Lafargue CJ, Scheble V, Wilbertz T, Ma C, Rao S, Nakagawa H, Stairs DB, Lin L, Giordano TJ, et al: SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet. 2009, 41 (11): 1238-1242. 10.1038/ng.465.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ji H, Zhao X, Yuza Y, Shimamura T, Li D, Protopopov A, Jung BL, McNamara K, Xia H, Glatt KA, Thomas RK, Sasaki H, Horner JW, Eck M, Mitchell A, Sun Y, Al-Hashem R, Bronson RT, Rabindran SK, Discafani CM, Maher E, Shapiro GI, Meyerson M, Wong KK: Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors. Proc Natl Acad Sci U S A. 2006, 103 (20): 7817-7822. 10.1073/pnas.0510284103.
Article
CAS
PubMed
PubMed Central
Google Scholar
Johnson JD, Edman JC, Rutter WJ: A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain. Proc Natl Acad Sci U S A. 1993, 90 (12): 5677-5681. 10.1073/pnas.90.12.5677.
Article
CAS
PubMed
PubMed Central
Google Scholar
Alves F, Vogel W, Mossie K, Millauer B, Hofler H, Ullrich A: Distinct structural characteristics of discoidin I subfamily receptor tyrosine kinases and complementary expression in human cancer. Oncogene. 1995, 10 (3): 609-618.
CAS
PubMed
Google Scholar
Luo Z, Liu H, Sun X, Guo R, Cui R, Ma X, Yan M: RNA interference against discoidin domain receptor 2 ameliorates alcoholic liver disease in rats. PLoS One. 2013, 8 (2): e55860-10.1371/journal.pone.0055860.
Article
CAS
PubMed
PubMed Central
Google Scholar
Olaso E, Labrador JP, Wang L, Ikeda K, Eng FJ, Klein R, Lovett DH, Lin HC, Friedman SL: Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2. J Biol Chem. 2002, 277 (5): 3606-3613. 10.1074/jbc.M107571200.
Article
CAS
PubMed
Google Scholar
Olaso E, Ikeda K, Eng FJ, Xu L, Wang LH, Lin HC, Friedman SL: DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells. J Clin Invest. 2001, 108 (9): 1369-1378. 10.1172/JCI200112373.
Article
CAS
PubMed
PubMed Central
Google Scholar
Xu L, Peng H, Wu D, Hu K, Goldring MB, Olsen BR, Li Y: Activation of the discoidin domain receptor 2 induces expression of matrix metalloproteinase 13 associated with osteoarthritis in mice. J Biol Chem. 2005, 280 (1): 548-555.
Article
CAS
PubMed
Google Scholar
Lee JM, Dedhar S, Kalluri R, Thompson EW: The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol. 2006, 172 (7): 973-981. 10.1083/jcb.200601018.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zavadil J, Bottinger EP: TGF-beta and epithelial-to-mesenchymal transitions. Oncogene. 2005, 24 (37): 5764-5774. 10.1038/sj.onc.1208927.
Article
CAS
PubMed
Google Scholar
Bremnes RM, Veve R, Gabrielson E, Hirsch FR, Baron A, Bemis L, Gemmill RM, Drabkin HA, Franklin WA: High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non-small-cell lung cancer. J Clin Oncol. 2002, 20 (10): 2417-2428. 10.1200/JCO.2002.08.159.
Article
CAS
PubMed
Google Scholar
Liu D, Huang C, Kameyama K, Hayashi E, Yamauchi A, Kobayashi S, Yokomise H: E-cadherin expression associated with differentiation and prognosis in patients with non-small cell lung cancer. Ann Thorac Surg. 2001, 71 (3): 949-954. 10.1016/S0003-4975(00)02545-5. discussion 954–945
Article
CAS
PubMed
Google Scholar