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  1. CC-chemokine receptor 7 (CCR7), a known lymph node homing receptor for immune cells, has been reported as a key molecule in lymph node metastasis. We hypothesized a clinicopathological correlation and function...

    Authors: Tomoyuki Irino, Hiroya Takeuchi, Sachiko Matsuda, Yoshiro Saikawa, Hirofumi Kawakubo, Norihito Wada, Tsunehiro Takahashi, Rieko Nakamura, Kazumasa Fukuda, Tai Omori and Yuko Kitagawa
    Citation: BMC Cancer 2014 14:291
    Content type: Research article Published on:

  2. The efficacy and safety of axitinib, a potent and selective second-generation inhibitor of vascular endothelial growth factor receptors 1, 2, and 3 in combination with pemetrexed and cisplatin was evaluated in...

    Authors: Chandra P Belani, Nobuyuki Yamamoto, Igor M Bondarenko, Artem Poltoratskiy, Silvia Novello, Jie Tang, Paul Bycott, Andreas G Niethammer, Antonella Ingrosso, Sinil Kim and Giorgio V Scagliotti
    Citation: BMC Cancer 2014 14:290
    Content type: Research article Published on:

  3. The objective of this study was to identify breast cancer patients with a high risk of developing brain metastases who may benefit from pre-emptive medical intervention.

    Authors: Volker Rudat, Hamdan El-Sweilmeen, Iris Brune-Erber, Alaa Ahmad Nour, Nidal Almasri, Saleh Altuwaijri and Elias Fadel
    Citation: BMC Cancer 2014 14:289
    Content type: Research article Published on:

  4. Malignant ascites is often present at diagnostic in women with advanced ovarian cancer (OC) and its presence is associated with a worse outcome. Human peritoneal mesothelial cells (HPMCs) are key components of...

    Authors: Isabelle Matte, Denis Lane, Dimcho Bachvarov, Claudine Rancourt and Alain Piché
    Citation: BMC Cancer 2014 14:288
    Content type: Research article Published on:

  5. The DNA damage checkpoint signalling cascade sense damaged DNA and coordinates cell cycle arrest, DNA repair, and/or apoptosis. However, it is still not well understood how the signalling system differentiates...

    Authors: Satish Bodakuntla, Libi Anandi V, Surojit Sural, Prasad Trivedi and Mayurika Lahiri
    Citation: BMC Cancer 2014 14:287
    Content type: Research article Published on:

  6. Mammary microcalcifications have a crucial role in breast cancer detection, but the processes that induce their formation are unknown. Moreover, recent studies have described the occurrence of the epithelial–m...

    Authors: Manuel Scimeca, Elena Giannini, Chiara Antonacci, Chiara Adriana Pistolese, Luigi Giusto Spagnoli and Elena Bonanno
    Citation: BMC Cancer 2014 14:286
    Content type: Research article Published on:

  9. Tamoxifen resistance is a major problem in the treatment of estrogen receptor (ER) α -positive breast cancer patients. Although the mechanisms behind tamoxifen resistance are still not completely understood, c...

    Authors: Marja Moerkens, Yinghui Zhang, Lynn Wester, Bob van de Water and John HN Meerman
    Citation: BMC Cancer 2014 14:283
    Content type: Research article Published on:

  10. The risk of hepatocellular carcinoma (HCC) increases in chronic hepatitis B surface antigen (HBsAg) carriers who often have concomitant increase in the levels of benzo[alpha]pyrene-7,8-diol-9,10-epoxide(±) (BP...

    Authors: Jin-Yan Chen, Wan-Nan Chen, Bo-Yan Jiao, Wan-Song Lin, Yun-Li Wu, Ling-Ling Liu and Xu Lin
    Citation: BMC Cancer 2014 14:282
    Content type: Research article Published on:

  11. Zalypsis® is a marine compound in phase II clinical trials for multiple myeloma, cervical and endometrial cancer, and Ewing’s sarcoma. However, the determinants of the response to Zalypsis are not well known. ...

    Authors: Victoria Moneo, Beatriz G Serelde, Carmen Blanco-Aparicio, Ramon Diaz-Uriarte, Pablo Avilés, Gemma Santamaría, Juan C Tercero, Carmen Cuevas and Amancio Carnero
    Citation: BMC Cancer 2014 14:281
    Content type: Research article Published on:

  12. Malignant pleural effusion (MPE) is a common complication of advanced lung cancer. Research has shown that secreted phosphoprotein-1 (SPP1) is essential in MPE associated with lung cancer. This retrospective s...

    Authors: He Zhang, Hong-bing Liu, Dong-mei Yuan, Zhao-feng Wang, Yun-fen Wang and Yong Song
    Citation: BMC Cancer 2014 14:280
    Content type: Research article Published on:

  13. Breast carcinoma can be classified as either Estrogen Receptor (ER) positive or negative by immunohistochemical phenotyping, although ER expression may vary from 1 to 100% of malignant cells within an ER + tum...

    Authors: Mark C Lloyd, Khalid O Alfarouk, Daniel Verduzco, Marilyn M Bui, Robert J Gillies, Muntaser E Ibrahim, Joel S Brown and Robert A Gatenby
    Citation: BMC Cancer 2014 14:279
    Content type: Research article Published on:

  14. The transcription factor GATA3 is a favorable prognostic indicator in estrogen receptor-α (ERα)-positive breast tumors in which it participates with ERα and FOXA1 in a complex transcriptional regulatory progra...

    Authors: Aleksandra B Adomas, Sara A Grimm, Christine Malone, Motoki Takaku, Jennifer K Sims and Paul A Wade
    Citation: BMC Cancer 2014 14:278
    Content type: Research article Published on:

  15. Colorectal cancer (CRC) is a disease of the elderly. However, geriatric patients are often excluded from clinical trials. The combination of capecitabine, oxaliplatin and bevacizumab (XELOX/BEV) has not been a...

    Authors: Lambros Vamvakas, Alexios Matikas, Athanasios Karampeazis, Dora Hatzidaki, Stelios Kakolyris, Charalampos Christophylakis, Ioannis Boukovinas, Aris Polyzos, Vassilis Georgoulias and John Souglakos
    Citation: BMC Cancer 2014 14:277
    Content type: Research article Published on:

  16. E2F1 transcription factor plays a vital role in the regulation of diverse cellular processes including cell proliferation, apoptosis, invasion and metastasis. E2F1 overexpression has been demonstrated in small...

    Authors: Zunling Li, Yanxia Guo, Hanming Jiang, Tingguo Zhang, Changzhu Jin, Charles YF Young and Huiqing Yuan
    Citation: BMC Cancer 2014 14:276
    Content type: Research article Published on:

  17. While glucocorticoids and the liganded glucocorticoid receptor (GR) have a well-established role in the maintenance of differentiation and suppression of apoptosis in breast tissue, the involvement of unligand...

    Authors: Heather D Ritter and Christopher R Mueller
    Citation: BMC Cancer 2014 14:275
    Content type: Research article Published on:

  18. CDK4 is a protein kinase in the CDK family important for G1/S phase cell cycle progression. However, the roles and molecular mechanisms of CDK4 triggering nasopharynx carcinogenesis are still unclear.

    Authors: Zhen Liu, Xiaobin Long, Cheng Chao, Chen Yan, Qiangyun Wu, Shengni Hua, Yajie Zhang, Aibing Wu and Weiyi Fang
    Citation: BMC Cancer 2014 14:274
    Content type: Research article Published on:

  20. There is evidence that cancer survivors are at increased risk of second primary cancers. Changes in the prevalence of risk factors and diagnostic techniques may have affected more recent risks.

    Authors: Aishah Coyte, David S Morrison and Philip McLoone
    Citation: BMC Cancer 2014 14:272
    Content type: Research article Published on:

  21. Cholangiocarcinoma (CCA), a devastating neoplasm, is highly resistant to current chemotherapies. CCA cells frequently overexpress the antiapoptotic protein myeloid cell leukemia-1(Mcl-1), which is responsible ...

    Authors: Xiwei Ding, Bin Zhang, Qingshan Pei, Jianmei Pan, Shuling Huang, Yan Yang, Zhu Zhu, Ying Lv and Xiaoping Zou
    Citation: BMC Cancer 2014 14:271
    Content type: Research article Published on:

  22. Cetuximab is a chimeric monoclonal antibody against the epidermal growth factor receptor (EGFR). Skin reactions are the most common side effects of cetuximab. Rhagades of the tips of the fingers and toes, the ...

    Authors: Karin Potthoff, Gregor Habl, Thomas Bruckner, Christian Suppan, Jessica Hassel, Dirk Jäger, Martin Indorf and Juergen Debus
    Citation: BMC Cancer 2014 14:270
    Content type: Study protocol Published on:

  23. The receptor for urokinase-type plasminogen activator (uPAR) is associated with cancer development and progression. Within the tumor microenvironment uPAR is expressed by malignant cells as well as tumor-assoc...

    Authors: Martin C Boonstra, Floris PR Verbeek, Andrew P Mazar, Hendrica AJM Prevoo, Peter JK Kuppen, Cornelis JH van de Velde, Alexander L Vahrmeijer and Cornelis FM Sier
    Citation: BMC Cancer 2014 14:269
    Content type: Research article Published on:

  24. Merkel cell carcinoma (MCC) is a rare cutaneous neoplasm with increasing incidence, aggressive behavior and poor prognosis. Somatostatin receptors (SSTR) are expressed in MCC and represent a potential target f...

    Authors: Kristina Buder, Constantin Lapa, Michael C Kreissl, Andreas Schirbel, Ken Herrmann, Alexander Schnack, Eva-Bettina Bröcker, Matthias Goebeler, Andreas K Buck and Jürgen C Becker
    Citation: BMC Cancer 2014 14:268
    Content type: Research article Published on:

  25. Despite the improvement in the care management, women cancer patients who are still in employment find themselves for the most part obliged to stop working while they are having treatment. Their return-to-work...

    Authors: Clémence Vidor, Ariane Leroyer, Véronique Christophe, Mélanie Seillier, Jérome Foncel, Justine Van de Maële, Jacques Bonneterre and Sophie Fantoni
    Citation: BMC Cancer 2014 14:267
    Content type: Study protocol Published on:

  26. Data from in vivo and in vitro studies suggest that activation of Akt regulates cell survival signaling and plays a key role in tumorigenesis. Hence, transgenic mice were created to explore the oncogenic role of ...

    Authors: Yanyuan Wu, Juri Kim, Yayha Elshimali, Marianna Sarkissyan and Jaydutt V Vadgama
    Citation: BMC Cancer 2014 14:266
    Content type: Research article Published on:

  27. In this study the feasibility of intensity-modulated radiotherapy (IMRT) and tomotherapy-based image-guided radiotherapy (IGRT) for locally advanced esophageal cancer was assessed.

    Authors: Nam P Nguyen, Siyoung Jang, Jacqueline Vock, Vincent Vinh-Hung, Alexander Chi, Paul Vos, Judith Pugh, Richard A Vo, Misty Ceizyk, Anand Desai and Lexie Smith-Raymond
    Citation: BMC Cancer 2014 14:265
    Content type: Research article Published on:

  28. Loss of lean body mass (LBM) is a common occurrence after treatment for breast cancer and is related to deleterious metabolic health outcomes [Clin Oncol, 22(4):281–288, 2010; Appl Physiol Nutr Metab, 34(5):950–9...

    Authors: Cameron McDonald, Judy Bauer, Sandra Capra and Joseph Coll
    Citation: BMC Cancer 2014 14:264
    Content type: Study protocol Published on:

  29. Evaluation of the effectiveness of a patient decision aid (nurse-managed telephone support line and/or colorectal cancer screening website), distributed to patients by their family physician, in improving feca...

    Authors: Kathleen Clouston, Alan Katz, Patricia J Martens, Jeff Sisler, Donna Turner, Michelle Lobchuk, Susan McClement and Gary Crow
    Citation: BMC Cancer 2014 14:263
    Content type: Research article Published on:

  30. Extraneural metastases (ENM) rarely occur in medulloblastoma (MBL) patients and only few cases of subcutaneous localizations have been described. ENM indicate an aggressive disease associated with a worse prog...

    Authors: Angela Mastronuzzi, Evelina Miele, Agnese Po, Manila Antonelli, Francesca Romana Buttarelli, Giovanna Stefania Colafati, Francesca del Bufalo, Roberta Faedda, Gian Paolo Spinelli, Andrea Carai, Felice Giangaspero, Alberto Gulino, Franco Locatelli and Elisabetta Ferretti
    Citation: BMC Cancer 2014 14:262
    Content type: Case report Published on:

  31. With 14.234 diagnoses and over 4047 deaths reported in 2007, colorectal cancer (CRC) is the second most common cancer and second most common cause of cancer-related mortality in Australia. The direct treatment...

    Authors: Driss A Ouakrim, Alex Boussioutas, Trevor Lockett, John L Hopper and Mark A Jenkins
    Citation: BMC Cancer 2014 14:261
    Content type: Research article Published on:

  33. Cathepsin X is a cysteine protease involved in mechanisms of malignant progression. It is secreted from tumour cells as a proenzyme and may serve to predict the disease status and risk of death for cancer pati...

    Authors: Tjaša Vižin, Ib Jarle Christensen, Michael Wilhelmsen, Hans Jørgen Nielsen and Janko Kos
    Citation: BMC Cancer 2014 14:259
    Content type: Research article Published on:

  35. STAT1 has been attributed a function as tumor suppressor. However, in breast cancer data from microarray analysis indicated a predictive value of high mRNA expression levels of STAT1 and STAT1 target genes bel...

    Authors: Piotr Tymoszuk, Pornpimol Charoentong, Hubert Hackl, Rita Spilka, Elisabeth Müller-Holzner, Zlatko Trajanoski, Peter Obrist, Françoise Revillion, Jean-Philippe Peyrat, Heidi Fiegl and Wolfgang Doppler
    Citation: BMC Cancer 2014 14:257
    Content type: Research article Published on:

  36. Tissue-transglutaminase (TG2), a dual function G-protein, plays key roles in cell differentiation and migration. In our previous studies we reported the mechanism of TG2-induced cell differentiation. In presen...

    Authors: Ambrish Kumar, Jianjun Hu, Holly A LaVoie, Kenneth B Walsh, Donald J DiPette and Ugra S Singh
    Citation: BMC Cancer 2014 14:256
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2016 16:609

  37. A large proportion of breast cancer cases are thought related to environmental factors. Identification of specific geographical areas with high risk (clusters) may give clues to potential environmental risk fa...

    Authors: Rikke Baastrup Nordsborg, Jaymie R Meliker, Annette Kjær Ersbøll, Geoffrey M Jacquez, Aslak Harbo Poulsen and Ole Raaschou-Nielsen
    Citation: BMC Cancer 2014 14:255
    Content type: Research article Published on:

  38. Although oral cavity, pharyngeal, oesophageal and gastric cancers share some risk factors, no comparative analysis of mortality rate trends in these illnesses has been undertaken in Spain. This study aimed to ...

    Authors: Daniel Seoane-Mato, Nuria Aragonés, Eva Ferreras, Javier García-Pérez, Marta Cervantes-Amat, Pablo Fernández-Navarro, Roberto Pastor-Barriuso and Gonzalo López-Abente
    Citation: BMC Cancer 2014 14:254
    Content type: Research article Published on:

  39. Breast cancer is the most common malignancy in women world-wide. Triple negative breast cancer (TNBC) is a highly aggressive subtype that lacks expression of hormone receptors for estrogen, progesterone and hu...

    Authors: Kelly A Avery-Kiejda, Stephen G Braye, John F Forbes and Rodney J Scott
    Citation: BMC Cancer 2014 14:253
    Content type: Research article Published on:

  40. The presence of hypoxia in head and neck squamous cell carcinoma (HNSCC) is associated with therapeutic resistance and increased risk of metastasis formation. αB-crystallin (HspB5) is a small heat shock protei...

    Authors: Chantal van de Schootbrugge, Elisabeth MJ Schults, Johan Bussink, Paul N Span, Reidar Grénman, Ger JM Pruijn, Johannes HAM Kaanders and Wilbert C Boelens
    Citation: BMC Cancer 2014 14:252
    Content type: Research article Published on:

  41. Renal cell carcinoma (RCC) is a malignant disease that demonstrates resistance to standard chemotherapeutic agents. Yet Active immunization using genetically modified dendritic cells holds promise for the adju...

    Authors: Danhong Wang, Bin Zhang, Haiyan Gao, Guoliang Ding, Qiong Wu, Jinchao Zhang, Li Liao and Hu Chen
    Citation: BMC Cancer 2014 14:251
    Content type: Research article Published on:

  43. Notch, IL-1 and leptin are known pro-angiogenic factors linked to breast cancer development, tumor aggressiveness and poor prognosis. A complex crosstalk between these molecules (NILCO) has been reported in br...

    Authors: Laronna S Colbert, Kaamilah Wilson, Sungjin Kim, Yuan Liu, Gabriela Oprea-Ilies, Corey Gillespie, Toi Dickson, Gale Newman and Ruben Rene Gonzalez-Perez
    Citation: BMC Cancer 2014 14:249
    Content type: Research article Published on:

  44. Hepatocellular carcinoma (HCC) has been associated with diabetes and obesity, but a possible connection with the metabolic syndrome (MetS) and its potential interaction with hepatitis and cirrhosis are open to...

    Authors: De-cai Yu, Jia Liu, Jun Chen, Jiao-jiao Shao, Xiao Shen, Hong-guang Xia, Chao-jun Li, Bin Xue and Yi-tao Ding
    Citation: BMC Cancer 2014 14:248
    Content type: Research article Published on:

  45. The antitumor drug nilotinib has a large inter- and intra individual variability in pharmacokinetics. Adherence to treatment may substantially influence plasma levels and has been recognized as the most import...

    Authors: Christel CLM Boons, Eleonora L Swart, Lonneke Timmers, Peter M van de Ven, Jeroen JWM Janssen and Jacqueline G Hugtenburg
    Citation: BMC Cancer 2014 14:247
    Content type: Study protocol Published on:

  46. Advanced squamous cervical cancer, one of the most commonly diagnosed cancers in women, still remains a major problem in oncology due to treatment failure and distant metastasis. Antitumor therapy failure is d...

    Authors: Ovidiu Balacescu, Loredana Balacescu, Oana Tudoran, Nicolae Todor, Meda Rus, Rares Buiga, Sergiu Susman, Bogdan Fetica, Laura Pop, Laura Maja, Simona Visan, Claudia Ordeanu, Ioana Berindan-Neagoe and Viorica Nagy
    Citation: BMC Cancer 2014 14:246
    Content type: Research article Published on:

  47. Hypermethylation of DNA is an epigenetic alteration commonly found in colorectal cancer (CRC) and can also be detected in blood samples of cancer patients. Methylation of the genes helicase-like transcription ...

    Authors: Alexander B Philipp, Dorothea Nagel, Petra Stieber, Rolf Lamerz, Isabel Thalhammer, Andreas Herbst and Frank T Kolligs
    Citation: BMC Cancer 2014 14:245
    Content type: Research article Published on:

  48. Prognostic multibiomarker signatures in prostate cancer (PCa) may improve patient management and provide a bridge for developing novel therapeutics and imaging methods. Our objective was to evaluate the associ...

    Authors: Anthony E Rizzardi, Nikolaus K Rosener, Joseph S Koopmeiners, Rachel Isaksson Vogel, Gregory J Metzger, Colleen L Forster, Lauren O Marston, Jessica R Tiffany, James B McCarthy, Eva A Turley, Christopher A Warlick, Jonathan C Henriksen and Stephen C Schmechel
    Citation: BMC Cancer 2014 14:244
    Content type: Research article Published on:

  49. Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic cancer. N,N’-dinitrosopiperazine (DNP), a carcinogen with specificity for nasopharyngeal epithelium, facilitates NPC metastasis. However, the und...

    Authors: Damao Huang, Yuejin Li, Na Liu, Zhenlin Zhang, Zhengke Peng, Chaojun Duan, Xiaowei Tang, Gongjun Tan, Guangrong Yan and Faqing Tang
    Citation: BMC Cancer 2014 14:243
    Content type: Research article Published on:

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