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  1. Since Immune response, nutritional status and Epstein–Barr Virus (EBV) DNA status have been confirmed to be relevant to the prognosis of patients with nasopharyngeal carcinoma (NPC), we believe that the combin...

    Authors: Shuting Wu, Xiaofei Yuan, Haoran Huang, Yanfei Li, Linchong Cui, Danfan Lin, Wenxuan Lu, Huiru Feng, Zilu Chen, Xiong Liu, Jiajie Tan and Fan Wang
    Citation: BMC Cancer 2023 23:1217
    Content type: Research Published on:

  2. Women living with HIV are at increased risk of developing cervical cancer (CC). Screening for cancer is an important preventive strategy for the early detection of precancerous lesions and its management. Ther...

    Authors: Easwaran Vigneshwaran, Narayana Goruntla, Bhavana Reddy Bommireddy, Mohammad Jaffar Sadiq Mantargi, Bhavani Mopuri, Durga Prasad Thammisetty, Kasturi Vishwanathasetty Veerabhadrappa and Sarad Pawar Naik Bukke
    Citation: BMC Cancer 2023 23:1216
    Content type: Research Published on:

  3. The objective of this study was to estimate the accuracy of transcriptome-based classifier in differential diagnosis of uterine leiomyoma and leiomyosarcoma. We manually selected 114 normal uterine tissue and ...

    Authors: Kidong Kim, Sarah Kim, TaeJin Ahn, Hyojin Kim, So-Jin Shin, Chel Hun Choi, Sungmin Park, Yong-Beom Kim, Jae Hong No and Dong Hoon Suh
    Citation: BMC Cancer 2023 23:1215
    Content type: Research Published on:

  4. CD147, a transmembrane glycoprotein, has been implicated in various cancer-related processes but its role in breast cancer remains poorly understood. Herein, we investigated the expression of CD147 in differen...

    Authors: Fang Li, Jing Wang, Yu-qiong Yan, Chong-zhi Bai and Ji-qiang Guo
    Citation: BMC Cancer 2023 23:1214
    Content type: Research Published on:

  6. Anastomotic leakage (AL) is a severe complication following esophagectomy with high mortality. Perioperative decreased serum albumin level is considered a predictive of AL, however, its impact on AL incidence ...

    Authors: Ying-Jian Wang, Xian-Feng Xie, Yi-Qiu He, Tao Bao, Xian-Dong He, Kun-Kun Li and Wei Guo
    Citation: BMC Cancer 2023 23:1212
    Content type: Research Published on:

  7. Human papillomavirus (HPV) has been confirmed as a major causative factor for malignant transformation of cervical epithelial cells and for the development of cervical intraepithelial neoplasia (CIN) and invas...

    Authors: Linghua Kong, Xiaoping Xiao, Tao Xu, Ru Wan and Fei Chen
    Citation: BMC Cancer 2023 23:1211
    Content type: Research Published on:

  8. The main aim of this study was to establish the clinicopathological and prognostic correlations between endometriosis-associated and non-endometriosis-associated primary ovarian cancer, with a view to providin...

    Authors: Huimin Wang, Cong Chen, Danbo Wang, Yanmei Zhu and Peng Chen
    Citation: BMC Cancer 2023 23:1210
    Content type: Research Published on:

  9. Immune checkpoint inhibitors of programmed cell death protein 1 (PD-1) represent a significant breakthrough in treating head and neck squamous cell carcinoma (HNSCC), with long-lasting responses and prolonged ...

    Authors: Carinato Hélène, Ombline Conrad, Carole Pflumio, Christian Borel, Manon Voegelin, Alexandre Bernard, Philippe Schultz, Mihaela-Alina Onea, Alain Jung, Sophie Martin and Mickaël Burgy
    Citation: BMC Cancer 2023 23:1209
    Content type: Study Protocol Published on:

  10. Evaluating the effects of cancer diagnosis and treatment on a patient’s overall well-being is crucial and health-related quality of life (HRQoL) is a reliable metric for assessing this impact. Little is known ...

    Authors: Md. Shahjalal, Marufa Sultana, Jeff Gow, Mohammad Enamul Hoque, Sabuj Kanti Mistry, Ahmed Hossain and Rashidul Alam Mahumud
    Citation: BMC Cancer 2023 23:1208
    Content type: Research Published on:

  11. Myeloproliferative neoplasms (MPNs) are a group of haematological malignancies that affect approximately 8 people in every 100,000 individuals in the UK. Little is known about the aetiology of MPNs, as previou...

    Authors: Nouf Abutheraa, Emma-Louise Tarburn, Charlene M. McShane, Andrew Duncombe, Mary Frances McMullin and Lesley Ann Anderson
    Citation: BMC Cancer 2023 23:1207
    Content type: Study Protocol Published on:

  12. Lymphocyte-activation gene 3 (LAG3) is an immune checkpoint receptor; novel LAG3 immune checkpoint inhibitors (ICIs) exhibit therapeutic activity in melanoma. The role of LAG3and ICIs of LAG3 are unknown in ma...

    Authors: Ken Arimura, Kenzo Hiroshima, Yoji Nagashima, Tadao Nakazawa, Akira Ogihara, Mami Orimo, Yasuto Sato, Hideki Katsura, Masato Kanzaki, Mitsuko Kondo and Etsuko Tagaya
    Citation: BMC Cancer 2023 23:1206
    Content type: Research Published on:

  13. Gastrointestinal (GI) cancers (gastric cancer, oesophageal cancer, liver cancer, colorectal cancer, etc.) are the most common cancers with the highest morbidity and mortality in the world. The therapy for most...

    Authors: Jing Gao, Jianqiang Lan, Haiyan Liao, Fang Yang, Pei Qiu, Feng Jin, Shubin Wang, Lin Shen, Tengfei Chao, Cheng Zhang and Yu Zhu
    Citation: BMC Cancer 2023 23:1205
    Content type: Review Published on:

  14. Though our previous study has demonstrated that the single-incision plus one-port laparoscopic surgery (SILS + 1) is safe and feasible for sigmoid colon and upper rectal cancer and has better short-term outcom...

    Authors: Xuehua Zhang, Haitao Yuan, Zilin Tan, Gaohua Li, Zhenzhao Xu, Jinfan Zhou, Jie Fu, Mingyi Wu, Jiafei Xi and Yanan Wang
    Citation: BMC Cancer 2023 23:1204
    Content type: Research Published on:

  16. Surgical resection followed by indicated adjuvant therapy offers potential curative treatment in colonic adenocarcinoma. Beyond the well-established seed and soil theory of colon cancer progression, the 'norma...

    Authors: Tharathorn Suwatthanarak, Pariyada Tanjak, Thanawat Suwatthanarak, Onchira Acharayothin, Kullanist Thanormjit, Amphun Chaiboonchoe, Thikhamporn Tawantanakorn, Chainarong Phalanusitthepha, Atthaphorn Trakarnsanga, Asada Methasate, Manop Pithukpakorn, Ryuichi Okamoto and Vitoon Chinswangwatanakul
    Citation: BMC Cancer 2023 23:1202
    Content type: Research Published on:

  17. Recapitulating the tumor microenvironment (TME) in vitro remains a major hurdle in cancer research. In recent years, there have been significant strides in this area, particularly with the emergence of 3D sphe...

    Authors: Khushwant Singh and Pramod K. Gautam
    Citation: BMC Cancer 2023 23:1201
    Content type: Research Published on:

  18. The mammalian target of rapamycin (mTOR) kinase, a central component of the PI3K/AKT/mTOR pathway, plays a critical role in tumor biology as an attractive therapeutic target. We conducted this first-in-human s...

    Authors: Jiani Wang, Lin Gui, Yuxin Mu, Jiayu Wang, Yihebali Chi, Zhenteng Liu, Qing Li and Binghe Xu
    Citation: BMC Cancer 2023 23:1200
    Content type: Research Published on:

  19. Textbook outcome (TO) is a composite measure reflecting various aspects of services provided to patients with solid malignancies. We sought to evaluate the importance of various TO components previously propos...

    Authors: L Bobrzynski, K Sędłak, K Rawicz-Pruszyński, P Kolodziejczyk, A Szczepanik, W Polkowski, P Richter and M Sierzega
    Citation: BMC Cancer 2023 23:1199
    Content type: Research Published on:

  20. Due to the high drug resistance of hepatocellular carcinoma (HCC), sorafenib has limited efficacy in the treatment of advanced HCC. Cancer-associated fibroblasts (CAFs) play an important regulatory role in the...

    Authors: Jiali Zhao, En Lin, Zirui Bai, Yingbin Jia, Bo Wang, Yihua Dai, Wenfeng Zhuo, Guifang Zeng, Xialei Liu, Chaonong Cai, Peiping Li, Baojia Zou and Jian Li
    Citation: BMC Cancer 2023 23:1198
    Content type: Research Published on:

  21. A worldwide increased incidence of HM has been marked in recent decades. Therefore, to update epidemiological characteristics of HM in a French West Indies territory, we have performed analysis through Martini...

    Authors: Rémi Houpert, Thierry Almont, Rostom Belahreche, Mamadi Faro, Jennie Okouango, Mylène Vestris, Jonathan Macni, Olivier Pierre-Louis, Christelle Montabord, Murielle Beaubrun-Renard, Naby Soumah, Martial Boisseau, Jacqueline Véronique-Baudin and Clarisse Joachim
    Citation: BMC Cancer 2023 23:1197
    Content type: Research Published on:

  22. Immunotherapy in combination with platinum-etoposide (EP) chemotherapy has been approved as a first-line treatment for extensive-stage small cell lung cancer (ES-SCLC). However, real-world (RW) data regarding ...

    Authors: Yanrong Wang, Lingling Li, Jia Hu, Yan Zhao, Huan Yan, Ming Gao, Xuejiao Yang, Xia Zhang, Junxun Ma and Guanghai Dai
    Citation: BMC Cancer 2023 23:1196
    Content type: Research Published on:

  23. To detect circulating tumor cells (CTCs) in the peripheral blood of patients with tumor, and to analyze the significance of CTC detection in tumor diagnosis and monitoring. In the present study, peripheral blo...

    Authors: Yuanrui Liu, Rong Zhao, Zaichun Xie, Zhiyu Pang, Shengjie Chen, Qian Xu and Zhanfeng Zhang
    Citation: BMC Cancer 2023 23:1195
    Content type: Research Published on:

  24. Myxofibrosarcoma is a rare malignant soft tissue sarcoma characterised by multiple local recurrence and can become of higher grade with each recurrence. Consequently, myxofibrosarcoma represents a burden for p...

    Authors: Ania Naila Guerrieri, Chiara Bellotti, Marianna Penzo, Marta Columbaro, Micaela Pannella, Alessandro De Vita, Marco Gambarotti, Laura Mercatali, Roberta Laranga, Barbara Dozza, Silvia Vanni, Serena Corsini, Tommaso Frisoni, Giacomo Miserocchi, Toni Ibrahim and Enrico Lucarelli
    Citation: BMC Cancer 2023 23:1194
    Content type: Research Published on:

  25. Tumor-infiltrating lymphocytes (TILs) by routine hematoxylin and eosin staining (H&E-TILs) are a robust prognostic biomarker in various cancers. However, the role of H&E-TILs in esophageal squamous cell carcin...

    Authors: Jifang Zheng, Hejun Zhang, Siya Li, Zhaoxin Kang, Fei Zheng, Qiwei Yao, Xueqing Zhang, Ziyi Wu, Jiezhong Wang, Weimin Fang, Jiancheng Li, Gang Chen, Yuangui Chen and Mingqiu Chen
    Citation: BMC Cancer 2023 23:1193
    Content type: Research Published on:

  26. The current gastric cancer staging system relies on the number of metastatic lymph nodes (MLNs) for nodal stage determination. However, incorporating additional information such as topographic status may help ...

    Authors: Chul-Hyo Jeon, Ki Bum Park, Hayemin Lee, Dong Jin Kim, Ho Seok Seo, Junhyun Lee, Kyung Hwa Jun, Jin Jo Kim and Han Hong Lee
    Citation: BMC Cancer 2023 23:1192
    Content type: Research Published on:

  27. Patients diagnosed with low-risk prostate cancer (PCa) are confronted with a difficult decision regarding whether to undergo definitive treatment or to pursue an active surveillance protocol. This is potential...

    Authors: Alice Guan, Eduardo J. Santiago-Rodríguez, Benjamin I. Chung, Janet K. Shim, Laura Allen, Mei-Chin Kuo, Kathie Lau, Zinnia Loya, James D. Brooks, Iona Cheng, Mindy C. DeRouen, Dominick L. Frosch, Todd Golden, John T. Leppert, Daphne Y. Lichtensztajn, Qian Lu…
    Citation: BMC Cancer 2023 23:1191
    Content type: Research Published on:

  28. Routine clinical staging for hepatocellular carcinoma (HCC) incorporates liver function, general health, and tumor morphology. Further refinement of prognostic assessments and treatment decisions may benefit f...

    Authors: Kong-Ying Lin, Qing-Jing Chen, Shi-Chuan Tang, Zhi-Wen Lin, Jian-Xi Zhang, Si-Ming Zheng, Yun-Tong Li, Xian-Ming Wang, Qiang Lu, Jun Fu, Luo-Bin Guo, Li-Fang Zheng, Peng-Hui You, Meng-Meng Wu, Ke-Can Lin, Wei-Ping Zhou…
    Citation: BMC Cancer 2023 23:1190
    Content type: Research Published on:

  30. Colorectal cancer (CRC) is a leading cause of cancer-related mortality, highlighting an unmet clinical need for more effective therapies. This study aims to evaluate the causal relationship between 4,489 plasm...

    Authors: Yi-Xin Cai, Yi-Qing Wu, Jie Liu, Huanle Pan, Wenhai Deng, Weijian Sun, Congying Xie and Xiu-Feng Huang
    Citation: BMC Cancer 2023 23:1188
    Content type: Research Published on:

  31. Chemoradiation therapy (CRT) followed by surgery is currently the standard of care to treat patients with locally advanced rectal cancer (LARC). CRT reduces local recurrences, but is associated with significan...

    Authors: D. M. Mens, J. M. van Rees, S. M. Wilting and C. Verhoef
    Citation: BMC Cancer 2023 23:1187
    Content type: Study Protocol Published on:

  32. Less than half of unselected metastatic cancer patients benefit from the immune checkpoint inhibitor (ICI) therapy. Systemic cancer-related inflammation may influence the efficacy of ICIs and thus, systemic in...

    Authors: Satu Tiainen, Veera Nurmela, Tuomas Selander, Patrik Turunen, Sanna Pasonen-Seppänen, Tiia Kettunen, Outi Kuittinen, Päivi Auvinen and Aino Rönkä
    Citation: BMC Cancer 2023 23:1186
    Content type: Research Published on:

  33. Hepatocellular carcinoma (HCC) is a major health concern, necessitating a deeper understanding of its prognosis and underlying mechanisms. This study aimed to investigate the mechanism and prognostic value of CD8

    Authors: Kejun Liu, Junhao Liu, Xusheng Zhang, Di Liu, Weijie Yao, Yang Bu and Bendong Chen
    Citation: BMC Cancer 2023 23:1185
    Content type: Research Published on:

  34. Up to the present time, there has remained a lack of strong evidence as to whether sentinel lymph node biopsy can replace lymphadenectomy for early endometrial cancer. The traditional surgery for endometrial c...

    Authors: Yanglong Guo, Lu Sun, Xi Chen, Qiang Wen, Zhuyan Shao, Xuedong Tang, XiaoJun Shi, Jinyu Wang, Yingli Zhang and Tao Zhu
    Citation: BMC Cancer 2023 23:1184
    Content type: Study protocol Published on:

  35. Obesity is a risk factor for breast cancer, and women with obesity that develop breast cancer have a worsened prognosis. Within the mammary gland, obesity causes chronic, macrophage-driven inflammation and adi...

    Authors: Genevra Kuziel, Brittney N. Moore, Grace P. Haugstad, Yue Xiong, Abbey E. Williams and Lisa M. Arendt
    Citation: BMC Cancer 2023 23:1183
    Content type: Research Published on:

  36. Patients diagnosed with small cell lung cancer (SCLC) typically experience a poor prognosis, and it is essential to predict overall survival (OS) and stratify patients based on distinct prognostic risks.

    Authors: Ziqian Song, Hengmin Ma, Hao Sun, Qiuxia Li, Yan Liu, Jing Xie, Yukun Feng, Yuwang Shang, Kena Ma, Nan Zhang and Jialin Wang
    Citation: BMC Cancer 2023 23:1182
    Content type: Research Published on:

  37. The predictive biomarkers of immune checkpoint inhibitors (ICIs) in hepatocellular carcinoma (HCC) still need to be further explored. This study aims to establish a new immune prognosis biomarker to predict th...

    Authors: Rujia Zhang, Haoran Zhao, Peng Wang, Zuoming Guo, Chunxun Liu and Zhaowei Qu
    Citation: BMC Cancer 2023 23:1181
    Content type: Research Published on:

  39. Osteosarcoma (OS) is the most common primary malignancy of bone tumors. More and more ARHGAP family genes have been confirmed are to the occurrence, development, and invasion of tumors. However, its significan...

    Authors: Wenda Liu, Kezhou Xia, Di Zheng, Xinghan Huang, Zhun Wei, Zicheng Wei and Weichun Guo
    Citation: BMC Cancer 2023 23:1179
    Content type: Research Published on:

  40. Many patients treated for breast cancer (BC) complain about cognitive difficulties affecting their daily lives. Recently, sleep disturbances and circadian rhythm disruptions have been brought to the fore as po...

    Authors: Clara Elia, Laura de Girolamo, Bénédicte Clarisse, Melvin Galin, Stéphane Rehel, Patrice Clochon, Franck Doidy, Shailendra Segobin, Fausto Viader, Mikaël Naveau, Nicolas Delcroix, Carine Segura-Djezzar, Jean-Michel Grellard, Justine Lequesne, Olivier Etard, Tristan Martin…
    Citation: BMC Cancer 2023 23:1178
    Content type: Study Protocol Published on:

  41. Breast cancer (BC) is one of the malignant diseases threatening the life and health of women worldwide. The CYP4B1 gene was abnormally expressed in BC and was associated with the prognosis of BC patients. This st...

    Authors: Yanhai Yin, Liangqian Tong, Zhenling Wan, Yanfang Sui, Fen Li, Qian Huang and Xinhan Zhao
    Citation: BMC Cancer 2023 23:1177
    Content type: Research Published on:

  43. Previous studies on cancer of unknown primary (CUP) mainly focus on treatment and prognosis in western populations and lacked clinical evaluation of different IHC markers, so this study aimed to evaluate chara...

    Authors: Min Ren, Xu Cai, Liqing Jia, Qianming Bai, Xiaoli Zhu, Xichun Hu, Qifeng Wang, Zhiguo Luo and Xiaoyan Zhou
    Citation: BMC Cancer 2023 23:1175
    Content type: Research Published on:

  44. In order to deliver appropriate and timely care planning and minimise avoidable late diagnoses, clinicians need to be aware of which patients are at higher risk of receiving a late cancer diagnosis. We aimed t...

    Authors: Sarah Mills, Peter Donnan, Deans Buchanan and Blair H. Smith
    Citation: BMC Cancer 2023 23:1174
    Content type: Research Published on:

  45. Angiogenesis is an important hallmark of Glioblastoma (GBM) marked by elevated vascular endothelial growth factor-A (VEGF-A) and its receptor 2 (VEGFR-2). As previously reported nimbolide (NBL), trans-chalcone...

    Authors: Anna Senrung, Tanya Tripathi, Joni Yadav, Divya Janjua, Apoorva Chaudhary, Arun Chhokar, Nikita Aggarwal, Udit Joshi, Nidhi Goswami and Alok Chandra Bharti
    Citation: BMC Cancer 2023 23:1173
    Content type: Research Published on:

  46. There is a lack of standard salvage treatment options for recurrent or metastatic nasopharyngeal carcinoma (RM-NPC) that has failed platinum-containing regimens. Breakthroughs in immunotherapy have opened up n...

    Authors: Jian Luo, Wanying Xiao, Fengyang Hua, Yanqing Cao, Dongxia Wang and Xicheng Wang
    Citation: BMC Cancer 2023 23:1172
    Content type: Research Published on:

  47. The aim of the study is to explore the role of preoperative folate receptor-positive circulating tumor cell (FR+CTC) levels in predicting disease-free survival (DFS) and overall survival (OS) in patients with eso...

    Authors: Qiang Zhou, Qiao He, Wenwu He, Chenghao Wang, Guangyuan Liu, Kangning Wang, Haojun Li, Jialong Li, Wenguang Xiao, Qiang Fang, Lin Peng, Yongtao Han, Dongsheng Wang and Xuefeng Leng
    Citation: BMC Cancer 2023 23:1171
    Content type: Research Published on:

  48. Immunoglobulin superfamily 6 (IGSF6) is a novel member of the immunoglobulin superfamily and has been implicated in various diseases. However, the specific role of IGSF6 in the anti-tumor immunity within lung ...

    Authors: Qisi Zheng, Ting Wang, Gechen Jiang, Miao Li, Zhi Zhang, Yuxin Chen and Xinyu Tian
    Citation: BMC Cancer 2023 23:1170
    Content type: Research Published on:

  49. Prophylactic irradiation of supraclavicular lymph node drainage areas can improve the regional control rate of lymph node-positive or lymph node-negative disease but a locally-advanced stage breast cancer, and...

    Authors: Li Li, Hongyan Zhang, Linwei Wang, Conghua Xie, Haijun Yu and Yahua Zhong
    Citation: BMC Cancer 2023 23:1168
    Content type: Research Published on:

  50. Vaginal CO2 laser therapy is a new treatment option for genitourinary syndrome of menopause. Its potential is particularly interesting in breast cancer survivors, where existing treatment options often are insuff...

    Authors: Sine Jacobsen, Marianne Glavind-Kristensen, Anders Bonde Jensen, Axel Forman and Pinar Bor
    Citation: BMC Cancer 2023 23:1164
    Content type: Study Protocol Published on:

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