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  1. Little is known about the safety and efficacy of concurrent capecitabine and stereotactic radiotherapy in the setting of breast cancer brain metastases (BCBM).

    Authors: Matthew N. Mills, Afrin Naz, Chetna Thawani, Chelsea Walker, Nicholas B. Figura, Sergiy Kushchayev, Daniel E. Oliver, Arnold B. Etame, Hsiang-Hsuan Michael Yu, Timothy J. Robinson, James K. C. Liu, Michael A. Vogelbaum, Peter A. Forsyth, Brian J. Czerniecki, Hatem H. Soliman, Hyo S. Han…

    Citation: BMC Cancer 2021 21:552

    Content type: Research

    Published on:

  2. Peripheral blood leukocyte (PBL) DNA methylation may serve as a surrogate marker to evaluate the susceptibility to and prognosis of gastric cancer (GC). In this study, blood-derived DNA methylation levels of t...

    Authors: Chuang Nie, Xu Han, Rongrong Wei, Anastasiia Leonteva, Jia Hong, Xinyu Du, Jing Wang, Lin Zhu, Yashuang Zhao, Yingwei Xue, Haibo Zhou and Wenjing Tian

    Citation: BMC Cancer 2021 21:551

    Content type: Research

    Published on:

  3. Postoperative pancreatic fistula (POPF) represents the most common complication following pancreaticoduodenectomy (PD). Predictive models are needed to select patients with a high risk of POPF. This study was ...

    Authors: Jian Shen, Feng Guo, Yan Sun, Jingyuan Zhao, Jin Hu, Zunxiang Ke, Yushun Zhang, Xin Jin and Heshui Wu

    Citation: BMC Cancer 2021 21:550

    Content type: Research

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  4. Chemotherapy-induced neutropenia (CIN) has been demonstrated to be a prognostic factor in several cancer conditions. We previously found a significant prognostic value of CIN on overall survival (OS), in a poo...

    Authors: Piera Gargiulo, Laura Arenare, Cesare Gridelli, Alessandro Morabito, Fortunato Ciardiello, Vittorio Gebbia, Paolo Maione, Alessia Spagnuolo, Giuliano Palumbo, Giovanna Esposito, Carminia Maria Della Corte, Floriana Morgillo, Gianfranco Mancuso, Raimondo Di Liello, Adriano Gravina, Clorinda Schettino…

    Citation: BMC Cancer 2021 21:549

    Content type: Research

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  5. Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect of paclitaxel (PTX). There is no known prophylactic measure, although there are some reports of prevention with compression therapy ...

    Authors: Haruru Kotani, Mitsuo Terada, Makiko Mori, Nanae Horisawa, Kayoko Sugino, Ayumi Kataoka, Yayoi Adachi, Naomi Gondou, Akiyo Yoshimura, Masaya Hattori, Masataka Sawaki, Chihoko Takahata, Makiko Kobara and Hiroji Iwata

    Citation: BMC Cancer 2021 21:548

    Content type: Research article

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  6. Photodynamic therapy (PDT) is an anticancer treatment that utilizes the interaction of light and a photosensitiser (PS), promoting tumour cell death mediated by generation of reactive oxygen species. In this s...

    Authors: Pablo Vallecorsa, Gabriela Di Venosa, M. Belén Ballatore, Dario Ferreyra, Leandro Mamone, Daniel Sáenz, Gustavo Calvo, Edgardo Durantini and Adriana Casas

    Citation: BMC Cancer 2021 21:547

    Content type: Research article

    Published on:

  7. Myelodysplastic syndromes (MDS) is a group of heterogeneous myeloid clonal diseases originating from hematopoietic stem cells. Clinically, elevated mature monocyte in bone marrow is often observed, but its cli...

    Authors: An Wu, Panpan Gao, Ningning Wu, Cong Shi, Zhenya Huang, Chunmeng Rong, Ye Sun, Lixia Sheng, Guifang Ouyang and Qitian Mu

    Citation: BMC Cancer 2021 21:546

    Content type: Research

    Published on:

  8. Pancreatic ductal adenocarcinoma (PDAC) is still a highly fatal malignancy among the most common cancers. More powerful treatments are expecting to bring hope for patients. Biweekly gemcitabine/nab-paclitaxel/...

    Authors: Chen Chang, Xiaofen Li and Dan Cao

    Citation: BMC Cancer 2021 21:545

    Content type: Study protocol

    Published on:

  9. One reason for the often late diagnosis of lung cancer (LC) may be that potentially-indicative sensations and symptoms are often diffuse, and may not be considered serious or urgent, making their interpretatio...

    Authors: Adrian Levitsky, Britt-Marie Bernhardson, Ingela Henoch, Maria Olin, Karl Kölbeck, Nadja Rystedt, Carol Tishelman and Lars E. Eriksson

    Citation: BMC Cancer 2021 21:544

    Content type: Research article

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  10. We identified differentiated thyroid cancer (DTC) survivors from SEER registries and performed Poisson regression to calculate the relative risks (RRs) of subsequent malignancies (SMs) by different sites assoc...

    Authors: Xiaoran Mei, Xiaoqin Yao, Fang Feng, Weiwei Cheng and Hui Wang

    Citation: BMC Cancer 2021 21:543

    Content type: Research

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  11. The aim of this study was to evaluate the relationship between pre-treatment plasma fibrinogen (Fib) level and pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer patients a...

    Authors: Yihua Wang, Yu Wang, Rui Chen, Zhenrong Tang, Yang Peng, Yudi Jin, Ailin Lan, Nan Ding, Yuran Dai, Linshan Jiang and Shengchun Liu

    Citation: BMC Cancer 2021 21:542

    Content type: Research article

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  12. EpCAM (Epithelial cell adhesion molecule) is often dysregulated in epithelial cancers. Prior studies implicate EpCAM in the regulation of oncogenic signaling pathways and epithelial-to-mesenchymal transition. ...

    Authors: Narendra V. Sankpal, Taylor C. Brown, Timothy P. Fleming, John M. Herndon, Anusha A. Amaravati, Allison N. Loynd and William E. Gillanders

    Citation: BMC Cancer 2021 21:541

    Content type: Research article

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  13. Nasopharyngeal cancer is distinguished from other cancers of the head and neck in its epidemiology, histopathology, clinical characteristics, and therapeutic outcome. Its unique clinico-epidemiologic pattern o...

    Authors: Elizabeth Tadesse Beyene, Siraw Girum Ketema, Assaye Nibret Alebachew, Mizan Yeshanew Saleh and Tsigereda Atumo Gebremariam

    Citation: BMC Cancer 2021 21:540

    Content type: Research

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  14. Undergoing cancer screening is a debatable topic in patients with cognitive impairment. In this study, we aimed to examine the utilization and predictors of breast and colorectal cancer screening among screeni...

    Authors: Shuang Yang, Jiang Bian, Thomas J. George, Karen Daily, Dongyu Zhang, Dejana Braithwaite and Yi Guo

    Citation: BMC Cancer 2021 21:539

    Content type: Research

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  15. Stereotactic body radiotherapy (SBRT) is becoming increasingly used in treating localized prostate cancer (PCa), with evidence showing similar toxicity and efficacy profiles when compared with longer courses o...

    Authors: Ting Martin Ma, James M. Lamb, Maria Casado, Xiaoyan Wang, T. Vincent Basehart, Yingli Yang, Daniel Low, Ke Sheng, Nzhde Agazaryan, Nicholas G. Nickols, Minsong Cao, Michael L. Steinberg and Amar U. Kishan

    Citation: BMC Cancer 2021 21:538

    Content type: Study protocol

    Published on:

  16. FOLFIRINOX (FFX) and Gemcitabine plus nab-paclitaxel (GnP) have been recommended as the first-line chemotherapy for metastatic pancreatic cancer (mPC). However, the evidence is lacking comparing not only two r...

    Authors: Jung Won Chun, Sang Hyub Lee, Joo Seong Kim, Namyoung Park, Gunn Huh, In Rae Cho, Woo Hyun Paik, Ji Kon Ryu and Yong-Tae Kim

    Citation: BMC Cancer 2021 21:537

    Content type: Research article

    Published on:

  17. At present, the characteristics of mucinous breast carcinoma (MBC) and the factors affecting its prognosis are controversial. We compared the clinical features of MBC with those of infiltrating ductal carcinom...

    Authors: Xingtong Zhou, Zhibo Zheng, Yan Li, Weiwei Zhao, Yan Lin, Jieshi Zhang and Qiang Sun

    Citation: BMC Cancer 2021 21:536

    Content type: Research article

    Published on:

  18. We reported previously that rectal cancer patients given curative-intent chemotherapy, radiation, and surgery for non-metastatic disease had enhanced risk of metastatic progression and death if circulating lev...

    Authors: Hanna Abrahamsson, Sebastian Meltzer, Vidar Nyløkken Hagen, Christin Johansen, Paula A. Bousquet, Kathrine Røe Redalen and Anne Hansen Ree

    Citation: BMC Cancer 2021 21:535

    Content type: Research article

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  19. Nasopharyngeal carcinoma (NPC) is a malignancy predominantly associated with infection by the Epstein-Barr virus (EBV). Approximately 12,900 new cases of NPC occur each year, with more than 70% of cases occurr...

    Authors: Jin-Hao Yang, Xue-Song Sun, Bei-Bei Xiao, Li-Ting Liu, Shan-Shan Guo, Jia-Dong Liang, Guo-Dong Jia, Lin-Quan Tang, Qiu-Yan Chen and Hai-Qiang Mai

    Citation: BMC Cancer 2021 21:534

    Content type: Research

    Published on:

  20. A pathologically confirmed negative margin is required when performing sublobar resection in patients with early stage peripheral lung adenocarcinoma. However, the optimal margin distance to ensure complete tu...

    Authors: Pan Yin, Bingqing Yue, Ji Zhang, Dong Liu, Dongyu Bai, Guang Zhao, Chutong Huang, Guojun Geng, Jie Jiang, Yongxiang Su, Xiuyi Yu and Jingyu Chen

    Citation: BMC Cancer 2021 21:533

    Content type: Research

    Published on:

  21. The clinical staging systems for adenocarcinoma of the esophagogastric junction (AEG) are controversial. We aimed to propose a prognostic nomogram based on real-world data for predicting survival of Siewert ty...

    Authors: Jian Chen, Yu-Jian Xia, Tian-Yu Liu, Yuan-Hui Lai, Ji-Shang Yu, Tian-Hao Zhang, Shiyin Ooi and Yu-Long He

    Citation: BMC Cancer 2021 21:532

    Content type: Research

    Published on:

  22. Cervical cancer continues to be one of the leading causes of cancer deaths among females in low and middle-income countries. In this study, we aimed to assess the independent prognostic value of clinical and p...

    Authors: Hui-Hui Chen, Wei-Yu Meng, Run-Ze Li, Qing-Yi Wang, Yu-Wei Wang, Hu-Dan Pan, Pei-Yu Yan, Qi-Biao Wu, Liang Liu, Xiao-Jun Yao, Min Kang and Elaine Lai-Han Leung

    Citation: BMC Cancer 2021 21:531

    Content type: Research article

    Published on:

  23. Osimertinib is a third generation tyrosine kinase inhibitor (TKI) that targets the epidermal growth factor receptor (EGFR) in lung cancer. However, although this molecule is not subject to some of the resistan...

    Authors: Ulrich Jarry, Mégane Bostoën, Raphaël Pineau, Laura Chaillot, Valentine Mennessier, Pierre Montagne, Emilie Motte, Marjorie Gournay, Arnaud Le Goff, Thierry Guillaudeux and Rémy Pedeux

    Citation: BMC Cancer 2021 21:530

    Content type: Technical advance

    Published on:

  24. Oxaliplatin-based therapy with FOLFOX-4 or CAPOX administered over 6 months remains the standard adjuvant treatment for stage III colon cancer (CC) patients. However, many patients experience dose reduction or...

    Authors: Jolanta Żok, Michał Bieńkowski, Barbara Radecka, Jan Korniluk, Krzysztof Adamowicz and Renata Duchnowska

    Citation: BMC Cancer 2021 21:529

    Content type: Research article

    Published on:

  25. Incidence of breast cancer continues to rise in low- and middle-income countries, with data from the East African country of Tanzania predicting an 82% increase in breast cancer from 2017 to 2030. We aimed to ...

    Authors: Rupali Sood, Nestory Masalu, Roisin M. Connolly, Christina A. Chao, Lucas Faustine, Cosmas Mbulwa, Benjamin O. Anderson and Anne F. Rositch

    Citation: BMC Cancer 2021 21:527

    Content type: Research

    Published on:

  26. Immigration has taken the central stage in world politics, especially in the developed countries like Germany, where the continuous flow of immigrants has been well documented since 1960s. Strikingly, emerging...

    Authors: Roman Rüdiger, Franziska Geiser, Manuel Ritter, Peter Brossart, Mignon-Denise Keyver-Paik, Andree Faridi, Hartmut Vatter, Friedrich Bootz, Jennifer Landsberg, Jörg C. Kalff, Ulrich Herrlinger, Glen Kristiansen, Torsten Pietsch, Stefan Aretz, Daniel Thomas, Lukas Radbruch…

    Citation: BMC Cancer 2021 21:526

    Content type: Research article

    Published on:

  27. Benefit of carboplatin and dose-dense weekly paclitaxel (ddCT) in first line treatment of ovarian cancer patients has been different in Western and Asian studies. In the present study we compare progression-fr...

    Authors: Rafaela Pirolli, Viviane Teixeira Loiola de Alencar, Felipe Leonardo Estati, Adriana Regina Gonçalves Ribeiro, Daniella Yumi Tsuji Honda, Mariana de Oliveira, Joao Paulo da Silveira Nogueira Lima, Elizabeth Santana dos Santos, Andrea Paiva Gadelha Guimarães, Glauco Baiocchi and Alexandre André Balieiro Anastácio da Costa

    Citation: BMC Cancer 2021 21:525

    Content type: Research

    Published on:

  28. Pancreatic head adenocarcinoma (PHAC), a malignant tumour, has a very poor prognosis, and the existing prognostic tools lack good predictive power. This study aimed to develop a better nomogram to predict over...

    Authors: Wenbo Zou, Zizheng Wang, Fei Wang, Gong Zhang and Rong Liu

    Citation: BMC Cancer 2021 21:524

    Content type: Research

    Published on:

  29. The purpose of this study was to explore clinicalpathology features, molecular features and outcome of male breast cancer patients who expressed ER, PR as well as HER-2, namely triple-positive male breast canc...

    Authors: Biyuan Wang, Hui Wang, Andi Zhao, Mi Zhang and Jin Yang

    Citation: BMC Cancer 2021 21:523

    Content type: Research article

    Published on:

  30. Neoadjuvant chemotherapy (NACT) was initially applied to locally advanced breast cancer to convert advanced lesions to an operable status. Currently, its application has been expanded to enhance overall oncolo...

    Authors: Jia-Ruei Yang, Wen-Ling Kuo, Chi-Chang Yu, Shin-Cheh Chen and Jung-Ju Huang

    Citation: BMC Cancer 2021 21:522

    Content type: Research article

    Published on:

  31. Complement component(C7) gene has been shown to influence the prognosis in Hepatocellular carcinoma (HCC) patients. The association between C7 and HCC recurrence after orthotopic liver transplantation (OLT), h...

    Authors: Zhongyi Jiang, Qianwei Jiang, Xu Fang, Pusen Wang, Weitao Que, Hao Li, Yang Yu, Xueni Liu, Chunguang Wang and Lin Zhong

    Citation: BMC Cancer 2021 21:521

    Content type: Research

    Published on:

  32. The presence of lateral pelvic lymph node (LLN) metastasis is an essential prognostic factor in rectal cancer patients. Thus, preoperative diagnosis of LLN metastasis is clinically important to determine the t...

    Authors: Ryohei Yukimoto, Mamoru Uemura, Takahiro Tsuboyama, Tsuyoshi Hata, Shiki Fujino, Takayuki Ogino, Norikatsu Miyoshi, Hidekazu Takahashi, Taishi Hata, Hirofumi Yamamoto, Tsunekazu Mizushima, Akira Kida, Mamoru Furuyashiki, Yuichiro Doki and Hidetoshi Eguchi

    Citation: BMC Cancer 2021 21:520

    Content type: Research

    Published on:

  33. To explore the combined predictive value of serum uric acid (SUA) and tumor response to induction chemotherapy (IC) in locally advanced nasopharyngeal carcinoma (LANPC) patients receiving IC followed by concur...

    Authors: Yuanji Xu, Zijie Wu, Wangzhong Ye, Youping Xiao, Wei Zheng, Qinyan Chen, Penggang Bai, Zhizhong Lin and Chuanben Chen

    Citation: BMC Cancer 2021 21:519

    Content type: Research

    Published on:

  34. RAS/BRAFV600E mutations are the most remarkable oncogenic driver mutations in colorectal cancer (CRC) and play an important role in treatment selection. No data are available regarding the clinical and prognostic...

    Authors: Tatsuki Ikoma, Mototsugu Shimokawa, Masahito Kotaka, Toshihiko Matsumoto, Hiroki Nagai, Shogen Boku, Nobuhiro Shibata, Hisateru Yasui and Hironaga Satake

    Citation: BMC Cancer 2021 21:518

    Content type: Research

    Published on:

  35. CA19–9 is one of the most widely used tumor markers in biliary-pancreatic diseases. The measured value may not factually reflect the genuine CA19–9 level secreted by tumor, which affected by biliary obstructio...

    Authors: Bangbo Zhao, Qin Cheng, Hongtao Cao, Xingtong Zhou, Tianhao Li, Liangbo Dong and Weibin Wang

    Citation: BMC Cancer 2021 21:517

    Content type: Research article

    Published on:

  36. In 2020, Morocco recorded more than 59,370 new cases of cancer and more than 35,265 cases of death (International Agency for Research on Cancer, Annual report Morocco, 2020). Cancer is always accompanied by so...

    Authors: Fahd Elkhalloufi, Saber Boutayeb, Fouzia Mamouch, Latifa Rakibi, Sanae Elazzouzi and Hassan Errihani

    Citation: BMC Cancer 2021 21:516

    Content type: Research article

    Published on:

  37. The treatment landscape for advanced non-small cell lung cancer (aNSCLC) has evolved rapidly since immuno-oncology (IO) therapies were introduced. This study used recent data to assess real-world treatment pat...

    Authors: Jason Lester, Carles Escriu, Sarah Khan, Emma Hudson, Talal Mansy, Andrew Conn, Samuel Chan, Ceri Powell, Juliet Brock, John Conibear, Lauren Nelless, Vaneet Nayar, Xiaohui Zhuo, Adeline Durand, Amerah Amin, Peter Martin…

    Citation: BMC Cancer 2021 21:515

    Content type: Research article

    Published on:

  38. While the introduction of checkpoint inhibitors (CPIs) as standard of care treatment for various tumor types has led to considerable improvements in clinical outcome, the majority of patients still fail to res...

    Authors: Mathieu Spaas, Nora Sundahl, Eva Hulstaert, Vibeke Kruse, Sylvie Rottey, Daan De Maeseneer, Veerle Surmont, Annabel Meireson, Lieve Brochez, Dries Reynders, Els Goetghebeur, Robbe Van den Begin, Dirk Van Gestel, Vincent Renard, Piet Dirix, Pieter Mestdagh…

    Citation: BMC Cancer 2021 21:514

    Content type: Study protocol

    Published on:

  39. Definitive radiation therapy (dRT) is an effective initial treatment of intermediate-risk (IR) and high-risk (HR) prostate cancer (PCa). PSMA PET/CT is superior to standard of care imaging (CT, MRI, bone scan)...

    Authors: Jeremie Calais, Shaojun Zhu, Nader Hirmas, Matthias Eiber, Boris Hadaschik, Martin Stuschke, Ken Herrmann, Johannes Czernin, Amar U. Kishan, Nicholas G. Nickols, David Elashoff and Wolfgang P. Fendler

    Citation: BMC Cancer 2021 21:512

    Content type: Study protocol

    Published on:

  40. Concurrent chemo-radiotherapy remains the standard treatment in unresectable stage III non-small-cell lung cancer (NSCLC) patients. Several studies have shown a potential value of concurrent epidermal growth f...

    Authors: Lucheng ZHU, Changlin Zou, Zhanchun Zhang, Jianfang Wang, Li Yang, Chuangzhou Rao, Zhiping Yang, Jiafeng Liang, Bing Xia and M. A. Shenglin

    Citation: BMC Cancer 2021 21:511

    Content type: Study protocol

    Published on:

  41. Disulfiram and metals inactivate key oncoproteins resulting in anti-neoplastic activity. The goal of this study was to determine the maximum tolerated dose of copper when administered with disulfiram in patien...

    Authors: Kristen C. Kelley, Kenneth F. Grossman, Mary Brittain-Blankenship, Kelli M. Thorne, Wallace L. Akerley, Moises C. Terrazas, Ken M. Kosak, Kenneth M. Boucher, Saundra S. Buys, Kimberly A. McGregor, Theresa L. Werner, Neeraj Agarwal, John R. Weis, Sunil Sharma, John H. Ward, Thomas P. Kennedy…

    Citation: BMC Cancer 2021 21:510

    Content type: Research

    Published on:

  42. Patients with myelodysplastic syndrome (MDS) require chronic red blood cell (RBC) transfusion due to anemia. Multiple RBC transfusions cause secondary iron overload and subsequent excessive generation of react...

    Authors: Lap Shu Alan Chan, Lilly ChunHong Gu and Richard A. Wells

    Citation: BMC Cancer 2021 21:509

    Content type: Research article

    Published on:

  43. Prostate cancer (CaP) cases are high in the United States. According to the American Cancer Society, there are an estimated number of 174,650 CaP new cases in 2019. The estimated number of deaths from CaP in 2...

    Authors: Justice Moses K. Aheto, Ovie A. Utuama and Getachew A. Dagne

    Citation: BMC Cancer 2021 21:508

    Content type: Research article

    Published on:

  44. Tumor necrosis factor alpha (TNFα) is a pleiotropic cytokine with both anti-tumorigenic and pro-tumorigenic activity, affecting tumor cell biology, the balance between cell survival and death. The final effect...

    Authors: Silvia Tyciakova, Valeria Valova, Barbora Svitkova and Miroslava Matuskova

    Citation: BMC Cancer 2021 21:507

    Content type: Research article

    Published on:

  45. The aim of this multicenter, randomized phase II study was to analyze the feasibility and safety of alternate-day S-1, an oral fluoropyrimidine, for adjuvant chemotherapy in patients with completely resected p...

    Authors: Norihito Okumura, Junichi Soh, Hiroyuki Suzuki, Masao Nakata, Toshiya Fujiwara, Hiroshige Nakamura, Makoto Sonobe, Takuji Fujinaga, Kazuhiko Kataoka, Kenichi Gemba, Masafumi Kataoka, Katsuyuki Hotta, Hiroshige Yoshioka, Keitaro Matsuo, Junichi Sakamoto, Hiroshi Date…

    Citation: BMC Cancer 2021 21:506

    Content type: Research article

    Published on:

  46. To investigate the feasibility, safety and efficacy of percutaneous radiofrequency ablation (RFA) of pulmonary metastases from hepatocellular carcinoma (HCC) contiguous with the mediastinum using the artificia...

    Authors: Taiyang Zuo, Wenli Lin, Fengyong Liu and Jinshun Xu

    Citation: BMC Cancer 2021 21:505

    Content type: Research article

    Published on:

  47. Lower prevalence HPV infection has been previously reported in Thai population when compared with Western countries. p16 expression indicates HPV-associated oropharyngeal squamous cell carcinoma (OPSCC), but n...

    Authors: Lalida Arsa, Teerada Siripoon, Narumol Trachu, Sasithorn Foyhirun, Duangjai Pangpunyakulchai, Suda Sanpapant, Natini Jinawath, Poompis Pattaranutaporn, Artit Jinawath and Nuttapong Ngamphaiboon

    Citation: BMC Cancer 2021 21:504

    Content type: Research article

    Published on:

  48. Studies on unresectable colorectal cancer liver metastasis(CRLM) rarely analyze the prognosis of the patients from the point of colonic subsites. We aimed to evaluate the effect of primary tumor resection (PTR...

    Authors: Jiefeng Zhao, Jinfeng Zhu, Rui Sun, Chao Huang, Rongfa Yuan and Zhengming Zhu

    Citation: BMC Cancer 2021 21:503

    Content type: Research article

    Published on:

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