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  1. Phosphatase and tensin homolog (PTEN) loss is associated with tumorigenesis, tumor progression, and therapy resistance in breast cancer. However, the clinical value of PTEN as a biomarker in these patients is ...

    Authors: Elham Sajjadi, Konstantinos Venetis, Roberto Piciotti, Donatella Gambini, Concetta Blundo, Letterio Runza, Stefano Ferrero, Elena Guerini-Rocco and Nicola Fusco

    Citation: BMC Cancer 2021 21:1152

    Content type: Research

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  2. This study aimed to evaluate the potential of metabolic activity of the psoas muscle measured by 18F-fluorodeoxyglucose positron emission tomography-computed tomography to predict treatment outcomes in patients w...

    Authors: Keunyoung Kim, In-Joo Kim, Kyoungjune Pak, Taewoo Kang, Young Mi Seol, Young Jin Choi and Hyojeong Kim

    Citation: BMC Cancer 2021 21:1151

    Content type: Research

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  3. Docetaxel in combination with two HER2-directed therapies, trastuzumab and pertuzumab, is the current standard frontline therapy for patients with metastatic HER2-positive breast cancer. Ado-trastuzumab (T-DM1...

    Authors: Luai S. Al Rabadi, Madeline M. Cook, Andy J. Kaempf, Megan M. Saraceni, Michael A. Savin and Zahi I. Mitri

    Citation: BMC Cancer 2021 21:1150

    Content type: Research

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  4. Aims to compare the prognostic performance of the number of positive lymph nodes (PLNN), lymph node ratio (LNR) and log odds of metastatic lymph nodes (LODDS) and establish a prognostic nomogram to predict ove...

    Authors: Linzhi Gao, Jun Lyu, Xiaoya Luo, Dong Zhang, Guifang Jiang, Xian Zhang, Xuesong Gao, Shaolie Zheng, Xiaoyu Wang and Yuan Shen

    Citation: BMC Cancer 2021 21:1149

    Content type: Research

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  5. Studies have shown that the skeletal muscle index at the third lumbar vertebra (L3 SMI) had reasonable specificity and sensitivity in nutritional assessment and prognostic prediction in digestive system cancer...

    Authors: Xiangliang Liu, Wei Ji, Kaiwen Zheng, Jin Lu, Lingyu Li, Jiuwei Cui and Wei Li

    Citation: BMC Cancer 2021 21:1148

    Content type: Research article

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  6. Germ cell tumors and sex cord stromal tumors are rare cancers of the ovary. They mainly affect young women and are associated with a high survival rate. The standard treatment mainly involves conservative surg...

    Authors: François Gernier, Djihane Ahmed-Lecheheb, Patricia Pautier, Anne Floquet, Cédric Nadeau, Sophie Frank, Jérôme Alexandre, Frédéric Selle, Dominique Berton-Rigaud, Elsa Kalbacher, Hubert Orfeuvre, Alain Lortholary, Paule Augereau, Fabien Labombarda, Lionel Perrier, Jean-Michel Grellard…

    Citation: BMC Cancer 2021 21:1147

    Content type: Study protocol

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  7. Early detection and appropriate treatment of precancerous, mucosal changes could significantly decrease the prevalence of life-threatening gastric cancer. Biopsy of the normal-appearing mucosa to detect Helicobac...

    Authors: Abbas Esmaeilzadeh, Ladan Goshayeshi, Robert Bergquist, Lida Jarahi, Alireza Khooei, Alireza Fazeli, Hooman Mosannen Mozaffari, Ali Bahari, Mohammad Bagher Oghazian and Benyamin Hoseini

    Citation: BMC Cancer 2021 21:1143

    Content type: Research

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  8. Mutations involving BRAF and TERT are important predictors of disease severity in thyroid cancer, but molecular testing is limited by cost and lack of adequate tissue sample. This study aimed to assess the uti...

    Authors: Brandon R. Rosvall, Morris Kostiuk, Jordana Williams, Ashlee Matkin, Jeffrey Harris, Hadi Seikaly, Daniel A. O’Connell and Vincent L. Biron

    Citation: BMC Cancer 2021 21:1142

    Content type: Research

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  9. Studies have shown that human polyomavirus infection may be associated with various human cancers. We investigated the potential relationship between the prevalence of JCPyVor BKPyV and prostate cancer (PC) in...

    Authors: Chenghuang Shen, Chunliang Tung, Chunnun Chao, Yeongchin Jou, Shupei Huang, Menghsiao Meng, Deching Chang and Peilain Chen

    Citation: BMC Cancer 2021 21:1141

    Content type: Research article

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  10. Cancer-related fatigue (CRF) is the most common side effect of cancer and cancer treatment. CRF prevalence is up to 50% in breast cancer patients and can continue several years after cancer remission. This per...

    Authors: M. Chartogne, A. Leclercq, B. Beaune, S. Boyas, C. Forestier, T. Martin, V. Thomas-Ollivier, S. Landry, H. Bourgeois, O. Cojocarasu, V. Pialoux, O. Zanna, L. A. Messonnier, A. Rahmani and B. Morel

    Citation: BMC Cancer 2021 21:1140

    Content type: Study protocol

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  11. Post hepatectomy liver failure (PHLF) remains a significant risk in patients undergoing curative liver resection for cancer, however currently available PHLF risk prediction investigations are not sufficiently...

    Authors: Mohamed Elsharif, Matthew Roche, Daniel Wilson, Susmita Basak, Ian Rowe, Dhakshina Vijayanand, Richard Feltbower, Darren Treanor, Lee Roberts, Ashley Guthrie, Raj Prasad, Mark S. Gilthorpe, Magdy Attia and Steven Sourbron

    Citation: BMC Cancer 2021 21:1139

    Content type: Study protocol

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  12. Compared to conventional adenocarcinoma (CA), mucin-producing adenocarcinoma (MPA) is an uncommon histological subtype and is usually separated from other histological types and has been evaluated separately. ...

    Authors: Qiang Wang, Junbin Zhong, Qing Huang, Zhuanpeng Chen, Jianchang Wei, Fang Wei and Jie Cao

    Citation: BMC Cancer 2021 21:1138

    Content type: Research

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  13. A colorectal resection is standard treatment for patients with colorectal cancer (CRC). However, the procedure results in significant post-operative mortality and reduced quality of life. Maximising pre-operat...

    Authors: Jamie Murdoch, Anna Varley, Jane McCulloch, Megan Jones, Laura B. Thomas, Allan Clark, Susan Stirling, David Turner, Ann Marie Swart, Kerry Dresser, Gregory Howard, John Saxton and James Hernon

    Citation: BMC Cancer 2021 21:1137

    Content type: Research

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  14. C5aR has been extensively studied in recent years as an essential component of the complement system. However, the role of C5aR in tumors has not been sufficiently investigated and summarized. The aim of this ...

    Authors: Ziran Wang, Wenwei Yu, Yawen Qiang, Fan Ma, Pengsheng Ding and Yangyan Wang

    Citation: BMC Cancer 2021 21:1136

    Content type: Research

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  15. Clear cell renal cell carcinoma (ccRCC) is one of the most lethal urological malignancies, but the pathogenesis and prognosis of ccRCC remain obscure, which need to be better understand.

    Authors: Yang Dong, Wei-ming Ma, Wen Yang, Lin Hao, Shao-qi Zhang, Kun Fang, Chun-hui Hu, Qian-jin Zhang, Zhen-duo Shi, Wen-da Zhang, Tao Fan, Tian Xia and Cong-hui Han

    Citation: BMC Cancer 2021 21:1135

    Content type: Research

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  16. Signaling through VEGF/VEGFR induces cancer angiogenesis and affects immune cells. An increasing number of studies have recently focused on combining anti-VEGF/VEGFR agents and immune checkpoint inhibitors (IC...

    Authors: Liting Xue, Xingyuan Gao, Haoyu Zhang, Jianxing Tang, Qian Wang, Feng Li, Xinxin Li, Xiaohong Yu, Zhihong Lu, Yue Huang, Renhong Tang and Wenqing Yang

    Citation: BMC Cancer 2021 21:1134

    Content type: Research

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  17. Virtual reality (VR) enables data visualization in an immersive and engaging manner, and it can be used for creating ways to explore scientific data. Here, we use VR for visualization of 3D histology data, cre...

    Authors: Kaisa Liimatainen, Leena Latonen, Masi Valkonen, Kimmo Kartasalo and Pekka Ruusuvuori

    Citation: BMC Cancer 2021 21:1133

    Content type: Technical advance

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  18. Locally recurrent rectal cancer (LRRC) remains a major problem after curative resection of primary rectal cancer. A noninvasive, prognostic biomarker with which to accurately evaluate disease status and assess...

    Authors: Mamoru Uemura, Masataka Ikeda, Rio Handa, Katsuki Danno, Junichi Nishimura, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Hirofumi Yamamoto, Mitsugu Sekimoto, Yuichiro Doki and Hidetoshi Eguchi

    Citation: BMC Cancer 2021 21:1132

    Content type: Research article

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  19. The V-Akt murine thymoma viral oncogene (AKT) 1 (E17K) is a subfamily of serine/threonine protein kinases that affects the survival, proliferation, and invasion of cancer cells. The clinicopathological features a...

    Authors: Tatsunori Shimoi, Jun Hashimoto, Kazuki Sudo, Akihiko Shimomura, Emi Noguchi, Chikako Shimizu, Mayu Yunokawa, Kan Yonemori, Hiroshi Yoshida, Masayuki Yoshida, Tomoyasu Kato, Takayuki Kinoshita, Takahiro Fukuda, Yasuhiro Fujiwara and Kenji Tamura

    Citation: BMC Cancer 2021 21:1131

    Content type: Research

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  20. To aid clinicians strategizing treatment for upper esophageal squamous cell carcinoma (ESCC), this retrospective study investigated associations between primary gross tumor volume (GTVp) and prognosis in patie...

    Authors: Yuanmei Chen, Qiuyuan Huang, Junqiang Chen, Yu Lin, Xinyi Huang, Qifeng Wang, Yong Yang, Bijuan Chen, Yuling Ye, Binglin Zheng, Rong Qi, Yushan Chen and Yuanji Xu

    Citation: BMC Cancer 2021 21:1130

    Content type: Research

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  21. The body mass index (BMI) is commonly used as a simple indicator of obesity; patients with early-stage breast cancer who are obese (OB) per BMI measurements have been shown to have high postoperative recurrenc...

    Authors: Koji Takada, Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Sae Ishihara, Tamami Morisaki, Masatsune Shibutani, Hiroaki Tanaka, Kosei Hirakawa and Masaichi Ohira

    Citation: BMC Cancer 2021 21:1129

    Content type: Research

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  22. Clinically, the coadministration of opioids to enhance antinociception and decrease tolerance has attracted increasing research attention. We investigated the effects of dezocine, a mu- and kappa-opioid recept...

    Authors: Lin-xin Wu, Yan-peng Dong, Qian-mei Zhu, Bo Zhang, Bo-lun Ai, Tao Yan, Guo-hua Zhang and Li Sun

    Citation: BMC Cancer 2021 21:1128

    Content type: Research

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  23. Caregivers are invaluable sources of support for individuals recovering from head and neck cancer (HNC). Accordingly, minimizing caregiver distress is essential to promote the well-being of both caregivers and...

    Authors: Zachary M. Kassir, Jinhong Li, Christine Harrison, Jonas T. Johnson and Marci L. Nilsen

    Citation: BMC Cancer 2021 21:1127

    Content type: Research

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  24. Not all patients with unresectable hepatocellular carcinoma (uHCC) benefit from treatment with immune checkpoint inhibitors and molecular-targeted agents. The aim of this retrospective study was to assess the ...

    Authors: Song Chen, Bo Xu, Zhiqiang Wu, Pengfei Wang, Weiguang Yu, Zhiyong Liu, Xiaoyong Huang, Yanqing Wu, Tengfei Li and Wenbo Guo

    Citation: BMC Cancer 2021 21:1126

    Content type: Research

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  25. Low- and middle-income countries (LMICs) experienced increasing rates of colorectal cancer (CRC) incidence in the last decade and lower 5-year survival rates compared to high-income countries (HICs) where the ...

    Authors: Désirée Schliemann, Kogila Ramanathan, Nicholas Matovu, Ciaran O’Neill, Frank Kee, Tin Tin Su and Michael Donnelly

    Citation: BMC Cancer 2021 21:1125

    Content type: Research article

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  26. Different pathological subtypes of invasive pulmonary adenocarcinoma (IPA) have different surgical methods and heterogeneous prognosis. It is essential to clarify IPA subtypes before operation and high-resolut...

    Authors: Pengju Zhang, Tianran Li, Xuemin Tao, Xin Jin and Shaohong Zhao

    Citation: BMC Cancer 2021 21:1124

    Content type: Research article

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  27. Favorable survival in malignant cutaneous melanoma (melanoma) has increased the likelihood of second primary cancer (SPC). We assess the influence of patient characteristics at diagnosis of first melanoma and ...

    Authors: Guoqiao Zheng, Subhayan Chattopadhyay, Kristina Sundquist, Jan Sundquist, Asta Försti, Akseli Hemminki and Kari Hemminki

    Citation: BMC Cancer 2021 21:1123

    Content type: Research

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  28. Actinomycin-D (Act-D) and Methotrexate (MTX) are both effective first-line agents for low-risk gestational trophoblastic neoplasia (LRGTN) with no consensus regarding which is more effective or less toxic. The...

    Authors: Jiatao Hao, Weihua Zhou, Mengzhao Zhang, Hui Yu, Taohong Zhang, Ruifang An and Yan Xue

    Citation: BMC Cancer 2021 21:1122

    Content type: Research

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  29. Synchronous oligometastatic non-small cell lung cancer (NSCLC) is generally characterised by the limited number of metastases at the time of diagnosis. Several clinical trials have shown that local ablative th...

    Authors: Taichi Miyawaki, Hirotsugu Kenmotsu, Hideyuki Harada, Yasuhisa Ohde, Yasutaka Chiba, Koji Haratani, Tamio Okimoto, Tomohiro Sakamoto, Kazushige Wakuda, Kentaro Ito, Takehiro Uemura, Shinya Sakata, Yoshihito Kogure, Yasumasa Nishimura, Kazuhiko Nakagawa and Nobuyuki Yamamoto

    Citation: BMC Cancer 2021 21:1121

    Content type: Study protocol

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  30. We investigated the performance improvement of physicians with varying levels of chest radiology experience when using a commercially available artificial intelligence (AI)-based computer-assisted detection (C...

    Authors: Daiju Ueda, Akira Yamamoto, Akitoshi Shimazaki, Shannon Leigh Walston, Toshimasa Matsumoto, Nobuhiro Izumi, Takuma Tsukioka, Hiroaki Komatsu, Hidetoshi Inoue, Daijiro Kabata, Noritoshi Nishiyama and Yukio Miki

    Citation: BMC Cancer 2021 21:1120

    Content type: Research article

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  31. Previous studies have observed a close association between hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC) as well as extrahepatic cancers. However, research concerning the effect of HBV i...

    Authors: Tong Liu, Wenqiang Li, Youcheng Zhang, Sarah Tan Siyin, Qi Zhang, Mengmeng Song, Kangping Zhang, Siqing Liu and Hanping Shi

    Citation: BMC Cancer 2021 21:1119

    Content type: Research article

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  32. Breast cancer chemoresistance is attributed to a wide variety of mechanisms, including autophagy. Transcription factor EB (TFEB) has been recently identified and characterized as one major regulator of autopha...

    Authors: Serena Bertozzi, Ambrogio P. Londero, Luigi Viola, Maria Orsaria, Michela Bulfoni, Stefania Marzinotto, Bruna Corradetti, Umberto Baccarani, Daniela Cesselli, Carla Cedolini and Laura Mariuzzi

    Citation: BMC Cancer 2021 21:1118

    Content type: Research article

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  33. Preoperative serum gamma-glutamyl transferase (γ-GT) levels is significantly related to the prognosis of hepatocellular carcinoma (HCC), but its clinical value in the management of postoperative adjuvant trans...

    Authors: Qiao Ke, Fu Xiang, Chunhong Xiao, Qizhen Huang, Xiaolong Liu, Yongyi Zeng, Lei Wang and Jingfeng Liu

    Citation: BMC Cancer 2021 21:1117

    Content type: Research article

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  34. Abdominal computed tomography (CT) is the standard imaging method for patients with suspected colorectal liver metastases (CRLM) in the diagnostic workup for surgery or thermal ablation. Diffusion-weighted and...

    Authors: B. Görgec, I. Hansen, G. Kemmerich, T. Syversveen, M. Abu Hilal, E. J. T. Belt, R. H. C. Bisschops, T. L. Bollen, K. Bosscha, M. C. Burgmans, V. Cappendijk, M. T. De Boer, M. D’Hondt, B. Edwin, H. Gielkens, D. J. Grünhagen…

    Citation: BMC Cancer 2021 21:1116

    Content type: Study protocol

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  35. Correct preoperative estimation of the malignant extent is crucial for optimal planning of breast cancer surgery. The sensitivity of mammography is lower in dense breasts, and additional imaging techniques are...

    Authors: Kristina Åhsberg, Anna Gardfjell, Emma Nimeus, Lisa Ryden and Sophia Zackrisson

    Citation: BMC Cancer 2021 21:1115

    Content type: Study protocol

    Published on:

  36. Today, cancer ranks as one of the leading causes of death. Despite the large number of novel available therapies, radiotherapy (RT) remains as the most effective non-surgical method to cure cancer patients. In...

    Authors: Tomás Merino, Mauricio P. Pinto, María Paz Orellana, Gonzalo Martinez, Marcelo Andía, Pablo Munoz-Schuffenegger, Francisco Acevedo, Luigi Gabrielli, Cesar Sanchez and Jaime Pereira

    Citation: BMC Cancer 2021 21:1114

    Content type: Study protocol

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  37. The outcome of patients with muscle-invasive bladder cancer (MIBC) remains poor, despite aggressive treatments. Inadequate primary staging, classically performed by computed tomography (CT)-imaging, could lead...

    Authors: Flor Verghote, Lindsay Poppe, Sofie Verbeke, Piet Dirix, Maarten Albersen, Gert De Meerleer, Charlien Berghen, Piet Ost, Geert Villeirs, Pieter De Visschere, Kathia De Man, Daan De Maeseneer, Sylvie Rottey, Charles Van Praet, Karel Decaestecker and Valérie Fonteyne

    Citation: BMC Cancer 2021 21:1113

    Content type: Study protocol

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  38. Tumor cells exhibit enhanced metabolism of nutrients to satisfy the demand of sustained proliferation in vivo. Seminal reports have presented evidence that tryptophan (Trp) metabolic reprogramming induced by a...

    Authors: Fan Li, Zhenyu Zhao, Zongbiao Zhang, Yan Zhang and Wei Guan

    Citation: BMC Cancer 2021 21:1112

    Content type: Research

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  39. Among patients with colorectal cancer (CRC) treated with oxaliplatin (L-OHP)-based chemotherapy, delayed chemotherapy-induced nausea and vomiting (CINV) have not been well controlled.

    Authors: Mototsugu Shimokawa, Toshinobu Hayashi, Junichi Nishimura, Taroh Satoh, Mutsumi Fukunaga, Reiko Matsui, Yasushi Tsuji, Fumitaka Mizuki and Takahiro Kogawa

    Citation: BMC Cancer 2021 21:1111

    Content type: Research

    Published on:

  40. As patients with cervical cancer and precancerous lesions can be diagnosed at early stage and live longer, it is imperative to understand their health-related quality of life so that better cancer-related poli...

    Authors: Min Zhao, Xin Pu, Yi Jun Yan, Shao Zhang, Xue Long, Lei Luo and Zheng Li

    Citation: BMC Cancer 2021 21:1110

    Content type: Research

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  41. The effect of dairy products intake on breast cancer (BC) is highly controversial. This study aims to investigate the relationship between dairy intake and BC incidence.

    Authors: Yujing He, Qinghua Tao, Feifei Zhou, Yuexiu Si, Rongrong Fu, Binbin Xu, Jiaxuan Xu, Xiangyuan Li and Bangsheng Chen

    Citation: BMC Cancer 2021 21:1109

    Content type: Research

    Published on:

  42. Diffuse gliomas are the most common malignant tumors of the central nervous system with poor treatment efficacy. Infiltration of immune cells into tumors during immunosurveillance is observed in multiple tumor...

    Authors: Constanze L. Kemmerer, Jens Schittenhelm, Evelyn Dubois, Laura Neumann, Lisa M. Häsler, Marius Lambert, Mirjam Renovanz, Stephan A. Kaeser, Ghazaleh Tabatabai, Ulf Ziemann, Ulrike Naumann and Markus C. Kowarik

    Citation: BMC Cancer 2021 21:1108

    Content type: Research article

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  43. EGFR and ALK alternations often contribute to human malignancies, including lung cancer. EGFR and ALK mutations are usually sensitive to EGFR-tyrosine kinase inhibitors (TKIs) and ALK-TKIs. Although generally ...

    Authors: Xiaodan Yang, Jia Zhong, Zhuo Yu, Minglei Zhuo, Min Zhang, Rongrong Chen, Xuefeng Xia and Jun Zhao

    Citation: BMC Cancer 2021 21:1107

    Content type: Research article

    Published on:

  44. Body mass index (BMI), waist and hip circumference are strongly correlated and do not reflect body composition. A Body Shape Index (ABSI) and Hip Index (HI) define waist and hip size among individuals with the...

    Authors: Sofia Christakoudi, Konstantinos K. Tsilidis, Evangelos Evangelou and Elio Riboli

    Citation: BMC Cancer 2021 21:1106

    Content type: Research article

    Published on:

  45. The current standard treatment for elderly patients with newly diagnosed glioblastoma is surgery followed by short-course radiotherapy with temozolomide. In recent studies, 40 Gy in 15 fractions vs. 60 Gy in 3...

    Authors: Yoshiki Arakawa, Keita Sasaki, Yohei Mineharu, Megumi Uto, Takashi Mizowaki, Junki Mizusawa, Yuta Sekino, Tomohiro Ono, Hidefumi Aoyama, Kaishi Satomi, Koichi Ichimura, Manabu Kinoshita, Makoto Ohno, Yoshinori Ito, Ryo Nishikawa, Haruhiko Fukuda…

    Citation: BMC Cancer 2021 21:1105

    Content type: Study protocol

    Published on:

  46. While underlying mechanisms and pathways of social inequalities in cancer survival have been extensively examined in adults, this is less so for children with cancer. Hypothesized mechanisms include prediagnos...

    Authors: Line Hjøllund Pedersen, Friederike Erdmann, Gitte Lerche Aalborg, Lisa Lyngsie Hjalgrim, Hanne Bækgaard Larsen, Kjeld Schmiegelow, Jeanette Falck Winther and Susanne Oksbjerg Dalton

    Citation: BMC Cancer 2021 21:1104

    Content type: Research

    Published on:

  47. Low-level viremia generally refers to detectable HBV DNA levels lower than 2000 IU/mL. Studies show that low-level viremia is a risk factor for hepatocellular carcinoma. The aim of this study was to explore th...

    Authors: Furong Sun, Zhifei Liu and Bingyuan Wang

    Citation: BMC Cancer 2021 21:1103

    Content type: Research article

    Published on:

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