Skip to content



Page 1 of 187

  1. Content type: Research article

    Hepatocellular carcinoma (HCC) is a malignant tumor that threatens global human health. High PKM2 expression is widely reported in multiple cancers, especially in HCC. This study aimed to explore the effects o...

    Authors: Wen-Wen Lv, Dahai Liu, Xing-Cun Liu, Tie-Nan Feng, Lei Li, Bi-Yun Qian and Wen-Xing Li

    Citation: BMC Cancer 2018 18:1150

    Published on:

  2. Content type: Research article

    The effect of sleep duration on cancer risk remains controversial. We aimed to quantify the available evidence on this relationship using categorical and dose–response meta-analyses.

    Authors: Yuheng Chen, Fengwei Tan, Luopei Wei, Xin Li, Zhangyan Lyu, Xiaoshuang Feng, Yan Wen, Lanwei Guo, Jie He, Min Dai and Ni Li

    Citation: BMC Cancer 2018 18:1149

    Published on:

  3. Content type: Research article

    Fertility sparing surgery has been extensively performed among patients with borderline ovarian tumors due to their age and favorable prognosis. Nevertheless, the prognosis and obstetric outcomes in these pati...

    Authors: Chenyan Fang, Lingqin Zhao, Xi Chen, Aijun Yu, Liang Xia and Ping Zhang

    Citation: BMC Cancer 2018 18:1147

    Published on:

  4. Content type: Research article

    Following up on previous work demonstrating the involvement of the transcription factor forkhead box M1 (FOXM1) in the biology and outcome of a high-risk subset of newly diagnosed multiple myeloma (nMM), this ...

    Authors: Chunyan Gu, Xuefang Jing, Carol Holman, Ramakrishna Sompallae, Fenghuang Zhan, Guido Tricot, Ye Yang and Siegfried Janz

    Citation: BMC Cancer 2018 18:1152

    Published on:

  5. Content type: Research article

    Radiomics is an emerging field in oncological research. In this study, we aimed at developing a radiomics score (rad-score) to estimate postoperative recurrence and survival in patients with solitary hepatocel...

    Authors: Bo-Hao Zheng, Long-Zi Liu, Zhi-Zhi Zhang, Jie-Yi Shi, Liang-Qing Dong, Ling-Yu Tian, Zhen-bin Ding, Yuan Ji, Sheng-Xiang Rao, Jian Zhou, Jia Fan, Xiao-Ying Wang and Qiang Gao

    Citation: BMC Cancer 2018 18:1148

    Published on:

  6. Content type: Research article

    Individuals with cancer have reduced quality of life, functionality, range of motion, strength, and an increase in pain and fatigue. Exergaming appears to be an effective rehabilitation tool for Parkinson’s di...

    Authors: Daniel Tough, Jonathan Robinson, Steven Gowling, Peter Raby, John Dixon and Samantha L. Harrison

    Citation: BMC Cancer 2018 18:1151

    Published on:

  7. Content type: Research article

    Three randomized trials have concluded at non inferiority of omission of complementary axillary lymph node dissection (cALND) for patients with involved sentinel node (SN). However, we can outline strong limit...

    Authors: Gilles Houvenaeghel, Monique Cohen, Pédro Raro, Jérémy De Troyer, Christine Tunon de Lara, Pierre Gimbergues, Tristan Gauthier, Christelle Faure-Virelizier, Véronique Vaini-Cowen, Stéphane Lantheaume, Claudia Regis, Emile Darai, Vivien Ceccato, Gauthier D’Halluin, Francesco Del Piano, Richard Villet…

    Citation: BMC Cancer 2018 18:1153

    Published on:

  8. Content type: Research article

    A minority of European countries have participated in international comparisons with high level data on lung cancer. However, the nature and extent of data collection across the continent is simply unknown, an...

    Authors: Anna Rich, David Baldwin, Inmaculada Alfageme, Paul Beckett, Thierry Berghmans, Stephen Brincat, Otto Burghuber, Alexandru Corlateanu, Tanja Cufer, Ronald Damhuis, Edvardas Danila, Joanna Domagala-Kulawik, Stefano Elia, Mina Gaga, Tuncay Goksel, Bogdan Grigoriu…

    Citation: BMC Cancer 2018 18:1144

    Published on:

  9. Content type: Study protocol

    African American adults experience a disproportionate burden and increased mortality for most solid tumor cancers and their adolescent children are negatively impacted by the illness experience. The purpose of...

    Authors: Nicole S. McKinney, Shannon Virtue, Frances Marcus Lewis, Alliric I. Willis, Tanisha Pettyjohn, La-Rhonda Harmon and Adam Davey

    Citation: BMC Cancer 2018 18:1140

    Published on:

  10. Content type: Research article

    The clinical factors that accurately predict the response to preoperative treatment in rectal cancer were yet unknown. The carcinoembryonic antigen (CEA) clearance pattern during neoadjuvant treatment has been...

    Authors: Huabin Hu, Jin Huang, Ping Lan, Lei Wang, Meijin Huang, Jianping Wang and Yanhong Deng

    Citation: BMC Cancer 2018 18:1145

    Published on:

  11. Content type: Study protocol

    Combining cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors with endocrine therapy is an effective strategy to improve progression-free survival in hormone receptor-positive (HR+), human epidermal growth fa...

    Authors: A. van Ommen-Nijhof, I. R. Konings, C. J. J. van Zeijl, C. A. Uyl-de Groot, V. van der Noort, A. Jager and G. S. Sonke

    Citation: BMC Cancer 2018 18:1146

    Published on:

  12. Content type: Research article

    This study aimed to explore hyper-O-linked N-acetylglucosaminylation (O-GlcNAcylation) with an elevation of the expression of O-linked-β-N-acetylglucosamine transferase (OGT) in human bladder cancer.

    Authors: Longsheng Wang, Shaojun Chen, Ziwei Zhang, Junfeng Zhang, Shiyu Mao, Jiayi Zheng, Yang Xuan, Mengnan Liu, Keke Cai, Wentao Zhang, Yadong Guo, Wei Zhai and Xudong Yao

    Citation: BMC Cancer 2018 18:1141

    Published on:

  13. Content type: Case report

    Multiple primary malignant tumors (MPMT) refers to the presence of two or more primary cancers of different organs in the same patient. MPMT is a sparse disease in the past, but there has been a gradual increa...

    Authors: Bo Jin, Simeng Zhang, Xin Chuang, Ping Yu, Ying Chen, Yuee Teng, Xiaofang Che, Yibo Fan, Chunlei Zheng, Xiaohan Li, Xueshan Qiu, Xiujuan Qu and Yunpeng Liu

    Citation: BMC Cancer 2018 18:1138

    Published on:

  14. Content type: Case report

    Adults with relapsed acute lymphoblastic leukemia (ALL) have a poor prognosis, especially in patients who relapsed within 6 months of complete remission 1 (CR1). Allogeneic hematopoietic stem cell transplantat...

    Authors: Shupeng Wen, Zhiyun Niu, Lina Xing, Ying Wang, Hang Li, Na Kuang, Jianmin Luo, Xuejun Zhang and Fuxu Wang

    Citation: BMC Cancer 2018 18:1143

    Published on:

  15. Content type: Case report

    Anal canal cancer occasionally accompanies extramammary Paget disease. Although most of them are squamous cell carcinoma, anal canal adenocarcinoma with neuroendocrine features accompanying secondary extramamm...

    Authors: Masamichi Yamaura, Takeshi Yamada, Rei Watanabe, Hitomi Kawai, Suguru Hirose, Hiroki Tajima, Masashi Sato, Yuichi Uchida, Daisuke Suganuma, Yoshiyuki Yamamoto, Toshikazu Moriwaki and Ichinosuke Hyodo

    Citation: BMC Cancer 2018 18:1142

    Published on:

  16. Content type: Research article

    Circulating tumor cells (CTCs) have been considered great clinical significance in various cancers. However, it remains unknown that how is the role of CTCs in patients with nasopharyngeal carcinoma (NPC). We ...

    Authors: Jing Zhang, Huashan Shi, Tingting Jiang, Zhe Liu, Peter P. Lin and Nianyong Chen

    Citation: BMC Cancer 2018 18:1133

    Published on:

  17. Content type: Research article

    The lymphocyte-to-monocyte ratio (LMR) has been used as a parameter reflecting systemic inflammation in several tumors, and is reportedly associated with prognosis in cancer patients. In this study, we evaluat...

    Authors: Wataru Goto, Shinichiro Kashiwagi, Yuka Asano, Koji Takada, Katsuyuki Takahashi, Takaharu Hatano, Tsutomu Takashima, Shuhei Tomita, Hisashi Motomura, Kosei Hirakawa and Masaichi Ohira

    Citation: BMC Cancer 2018 18:1137

    Published on:

  18. Content type: Research article

    Oesophageal carcinoma (OC) is one of the leading cancers in Sri Lanka. Its increasing incidence despite the implementation of various preventive activities addressing the conventional risk factors indicates th...

    Authors: Ishanka Ayeshwari Talagala, Metthananda Nawarathne and Carukshi Arambepola

    Citation: BMC Cancer 2018 18:1135

    Published on:

  19. Content type: Research article

    Hepatocellular carcinoma (HCC) is a common cancer worldwide, with a poor prognosis. Most patients are diagnosed at advanced stages and are only eligible for palliative therapy. Therefore, this study aimed to e...

    Authors: Shiguang Chen, Wenchang Yu, Kongzhi Zhang and Weifu Liu

    Citation: BMC Cancer 2018 18:1131

    Published on:

  20. Content type: Study protocol

    Graft-versus-Host Disease (GvHD) causes significant morbidity and mortality in patients after allogeneic stem cell transplantation. Donor T-cells cause inflammation and tissue damage in GvHD target organs such...

    Authors: Nikolas von Bubnoff, Gabriele Ihorst, Olga Grishina, Nadine Röthling, Hartmut Bertz, Justus Duyster, Jürgen Finke and Robert Zeiser

    Citation: BMC Cancer 2018 18:1132

    Published on:

  21. Content type: Case report

    Nuclear protein in testis (NUT) carcinoma (NC) is a rare epithelial malignancy characterized by rearrangement of the NUT gene on chromosome 15. If NC is not suspected, it is often diagnosed as other malignancies....

    Authors: Kohei Arimizu, Gen Hirano, Chinatsu Makiyama, Mioko Matsuo, Takakazu Sasaguri and Akitaka Makiyama

    Citation: BMC Cancer 2018 18:1134

    Published on:

  22. Content type: Research article

    On-target resistance mechanisms found in one-third of patients receiving anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) are secondary ALK mutations in ALK-rearranged non-small cell lung cancer...

    Authors: Ryohei Yoshida, Takaaki Sasaki, Yasuhiro Umekage, Sachie Tanno, Yusuke Ono, Munehiko Ogata, Shinichi Chiba, Yusuke Mizukami and Yoshinobu Ohsaki

    Citation: BMC Cancer 2018 18:1136

    Published on:

  23. Content type: Research article

    The ZOHé study was a prospective, non-interventional, multicentre study in France to assess the use of biosimilar filgrastim Zarzio® (Sandoz filgrastim) in routine clinical practice in patients at risk of neut...

    Authors: Henri Roché, Jean-Christophe Eymard, Abderraouf Radji, Alain Prevost, Rafik Diab, Michele Lamuraglia, Ravaka-Fatoma Soumoudronga, Isabelle Gasnereau and Alain Toledano

    Citation: BMC Cancer 2018 18:1127

    Published on:

  24. Content type: Research article

    Interactions between the protein synthesis inhibitor homoharringtonine (HHT) and the proteasome inhibitor bortezomib were investigated in DLBCL and mantle cell lymphoma cells (MCL).

    Authors: Tri Nguyen, Rebecca Parker, Yu Zhang, Elisa Hawkins, Maciej Kmieciak, William Craun and Steven Grant

    Citation: BMC Cancer 2018 18:1129

    Published on:

  25. Content type: Research article

    The French West-Indies rank first for both prostate cancer incidence and mortality rates. Analyzing diagnostic and therapeutic procedures among patients with prostate cancer, using data from a population-based...

    Authors: Clarisse Joachim, Jacqueline Veronique-Baudin, Stephen Ulric-Gervaise, Jonathan Macni, Thierry Almont, Olivier Pierre-Louis, Lidvine Godaert, Moustapha Drame, Jean-Luc Novella, Karim Farid, Vincent Vinh-Hung and Patrick Escarmant

    Citation: BMC Cancer 2018 18:1130

    Published on:

  26. Content type: Research article

    Trifluridine/tipiracil (TAS-102, Lonsurf®), a novel oral anti-tumor agent combining an anti-neoplastic thymidine-based nucleoside analogue (trifluridine, FTD) with a thymidine phosphorylase inhibitor (tipiraci...

    Authors: Stefan Kasper, Jens Kisro, Martin Fuchs, Christian Müller, Armin Schulz-Abelius, Meinolf Karthaus, Mohammad-Reza Rafiyan and Alexander Stein

    Citation: BMC Cancer 2018 18:1124

    Published on:

  27. Content type: Research article

    Karyopherin β1 (Kpnβ1) is the main nuclear import protein involved in the transport of cargoes from the cytoplasm into the cell nucleus. Previous research has found Kpnβ1 to be significantly overexpressed in c...

    Authors: Sarah Carden, Pauline van der Watt, Alicia Chi, Aderonke Ajayi-Smith, Katie Hadley and Virna D. Leaner

    Citation: BMC Cancer 2018 18:1123

    Published on:

  28. Content type: Research article

    The large-conductance, voltage-gated, calcium (Ca (2+))-activated potassium channel (BKCa) plays an important role in regulating Ca (2+) signaling and cell physiological function, and is aberrantly expressed i...

    Authors: Fenfen Wang, Qin Chen, Genping Huang, Xuedong Guo, Na Li, Yang Li and Baohua Li

    Citation: BMC Cancer 2018 18:1128

    Published on:

  29. Content type: Research article

    To compare dual energy CT iodine imaging and standardized iodine concentration before and after chemoradiotherapy (CRT) for esophageal cancer and evaluate the efficacy of CRT for EC by examining DECT iodine ma...

    Authors: Xiaomin Ge, Jingping Yu, Zhongling Wang, Yiqun Xu, Changjie Pan, Lu Jiang, Yanling Yang, Kai Yuan and Wei Liu

    Citation: BMC Cancer 2018 18:1120

    Published on:

  30. Content type: Research article

    Neuroendocrine tumours are uncommon tumours; there is often a long period between the onset of symptoms and diagnosis. This study aims to address the symptoms prior to diagnosis of people with known neuroendoc...

    Authors: Ron Basuroy, Catherine Bouvier, John Keith Ramage, Maia Sissons and Raj Srirajaskanthan

    Citation: BMC Cancer 2018 18:1122

    Published on:

  31. Content type: Study protocol

    Gastric cancer is one of the most common malignant tumors worldwide. With the rapid aging of global population, the number of elderly patients with local advanced gastric cancer is increasing. Surgery is the e...

    Authors: Ziyu Li, Fei Shan, Xiangji Ying, Kan Xue and Jiafu Ji

    Citation: BMC Cancer 2018 18:1118

    Published on:

  32. Content type: Case report

    Intracranial germinomas are one of the most radiosensitive tumors and are curable by radiotherapy (RT) alone. RT-only therapy without chemotherapy is effective. But, as patients with germinoma can expect long-...

    Authors: Kihwan Hwang, Kyu Sang Lee, Gheeyoung Choe, Byung-Gyu Cho and Chae-Yong Kim

    Citation: BMC Cancer 2018 18:1119

    Published on:

  33. Content type: Research article

    Outpatient autologous stem cell transplantations (ASCTs) in multiple myeloma and lymphoma patients have been shown to reduce the overall costs and improve the quality of life relative to inpatient ASCTs. This ...

    Authors: Weerapat Owattanapanich, Kittima Suphadirekkul, Chutima Kunacheewa, Patompong Ungprasert and Kannadit Prayongratana

    Citation: BMC Cancer 2018 18:1126

    Published on:

  34. Content type: Research article

    Liver fibrosis is involved in hepatocellular carcinoma (HCC), but its effect on the survival of patients with HCC remains controversial. This study aims to explore whether the severity of liver fibrosis has an...

    Authors: Hui Liu, Dong Cen, Yunxian Yu, Yanting Wang, Xiao Liang, Hui Lin and Xiujun Cai

    Citation: BMC Cancer 2018 18:1125

    Published on:

  35. Content type: Research article

    With advances in gastric cancer chemotherapy, conversion surgery has drawn attention as a new strategy to improve the outcome of stage IV disease. We investigated the efficacy of conversion surgery following c...

    Authors: Seung-Hoon Beom, Yoon Young Choi, Song-Ee Baek, Shuang-Xi Li, Joon Seok Lim, Taeil Son, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Seung Ho Choi, Minkyu Jung, Hyo Song Kim, Hei-Cheul Jeung, Hyun Cheol Chung, Sun Young Rha and Sung Hoon Noh

    Citation: BMC Cancer 2018 18:1116

    Published on:

  36. Content type: Research article

    To identify potential therapeutic target in clear cell renal cell carcinoma (ccRCC), we performed a transcriptome analysis. Our analysis showed that fatty acid binding protein 7 (FABP7) has the highest mean di...

    Authors: Kazuhiro Nagao, Nachi Shinohara, Frank Smit, Mirjam de Weijert, Sander Jannink, Yuji Owada, Peter Mulders, Egbert Oosterwijk and Hideyasu Matsuyama

    Citation: BMC Cancer 2018 18:1114

    Published on:

  37. Content type: Study protocol

    Cancer has a lot of consequences on patients’ quality of life (such as cancer-related fatigue (CRF), sleep difficulties and emotional distress) and on patients’ partners and their relationship, such as distres...

    Authors: Charlotte Grégoire, Marie-Elisabeth Faymonville, Audrey Vanhaudenhuyse, Vanessa Charland-Verville, Guy Jerusalem and Isabelle Bragard

    Citation: BMC Cancer 2018 18:1113

    Published on:

  38. Content type: Case report

    Intravascular lymphoma is a rare type of non-Hodgkin lymphoma mostly of B-cell lineage. A few cases of intravascular lymphoma have been found to be of NK/T-cell origin, mainly affecting the skin and central ne...

    Authors: Magda Zanelli, Maria Cecilia Mengoli, Rachele Del Sordo, Angelo Cagini, Loredana De Marco, Edoardo Simonetti, Giovanni Martino, Maurizio Zizzo and Stefano Ascani

    Citation: BMC Cancer 2018 18:1115

    Published on:

  39. Content type: Case report

    Extramedullary involvement of B-cell Acute Lymphoblastic Leukemia (EM-ALL) is a rare occurrence, characterized by dismal outcome and the absence of a defined and shared therapeutic approach. In the landscape o...

    Authors: Luca Bertamini, Jacopo Nanni, Giovanni Marconi, Mariachiara Abbenante, Valentina Robustelli, Francesco Bacci, Antonella Matti, Stefania Paolini, Chiara Sartor, Silvia Lo Monaco, Maria Chiara Fontana, Stefano De Polo, Michele Cavo, Antonio Curti, Giovanni Martinelli and Cristina Papayannidis

    Citation: BMC Cancer 2018 18:1117

    Published on:

  40. Content type: Case report

    Sacral chordoma is a locally aggressive malignant tumour originating from ectopic notochordal cells. The natural history of sacral chordoma is a slow growing tumour arising at the midline of the lower sacrum t...

    Authors: Zi Hao Phang, Xue Yi Saw, Noreen Fadzlina Binti Mat Nor, Zolqarnain Bin Ahmad and Sa’adon Bin Ibrahim

    Citation: BMC Cancer 2018 18:1112

    Published on:

  41. Content type: Research article

    Colorectal cancer has been found to be attenuated either with prophylactic manipulation of gut microbiome with probiotics or celecoxib, a non-steroidal anti-inflammatory drug mainly by suppressing early pro-ca...

    Authors: Leila Kaeid Sharaf, Mridul Sharma, Deepika Chandel and Geeta Shukla

    Citation: BMC Cancer 2018 18:1111

    Published on:

  42. Content type: Research article

    Various efforts to understand the relationship between biological information and disease have been done using many different types of highthroughput data such as genomics and metabolomics. However, informatio...

    Authors: Jaesik Jeong, Kwangok Seo and Eung-Sam Kim

    Citation: BMC Cancer 2018 18:1109

    Published on:

  43. Content type: Research article

    Earlier diagnosis is beneficial for the prognosis of hepatocellular carcinoma (HCC). Alpha fetoprotein (AFP) is the most widely used biomarker for HCC, but its sensitivity and specificity are only 60 and 90%, ...

    Authors: Chenghua Zhang, Ran Xia, Bo Zhang and Haibo Wang

    Citation: BMC Cancer 2018 18:1110

    Published on:

  44. Content type: Research article

    To compare the efficacy of low dose (27 mg) Bacillus Calmette-Guérin (BCG) and a full dose (81 mg) BCG immunotherapy for patients with intermediate and high-risk non-muscle invasive bladder cancer (NMIBC) afte...

    Authors: Zongren Wang, Han Xiao, Guangyan Wei, Ning Zhang, Mengchao Wei, Zebin Chen, Zhenwei Peng, Sui Peng, Shaopeng Qiu, Heping Li and Jianting Long

    Citation: BMC Cancer 2018 18:1108

    Published on:

  45. Content type: Research article

    In a previous study utilizing mass spectrometry-based proteomics, we identified calcium-activated chloride channel regulator 1 (CLCA1) as a potential tumor suppressor in pancreatic cancer and the expression wa...

    Authors: Dingyuan Hu, Daniel Ansari, Qimin Zhou, Agata Sasor, Katarzyna Said Hilmersson, Monika Bauden, Yi Jiang and Roland Andersson

    Citation: BMC Cancer 2018 18:1096

    Published on:

  46. Content type: Research article

    Triptolide induces apoptosis and DNA damage followed by inhibition of DNA repair associated gene expression. However, there is the limited data for biomarker to predict the benefit to triptolide in various can...

    Authors: Seung Tae Kim, Sun Young Kim, Jeeyun Lee, Kyung Kim, Se Hoon Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang and Joon Oh Park

    Citation: BMC Cancer 2018 18:1103

    Published on:

  47. Content type: Research article

    In patients with locally advanced rectal cancer treated by neoadjuvant chemoradiation, pathological complete response in the surgical specimen is associated with favourable long-term oncologic outcome. Based o...

    Authors: Claudio Belluco, Marco Forlin, Paolo Delrio, Daniela Rega, Maurizio Degiuli, Silvia Sofia, Matteo Olivieri, Salvatore Pucciarelli, Matteo Zuin, Giovanni De Manzoni, Alberto Di Leo, Stefano Scabini, Luigi Zorcolo and Angelo Restivo

    Citation: BMC Cancer 2018 18:1094

    Published on:

Featured videos

View featured videos from across the BMC-series journals