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3909 result(s) for 'lung cancer prognosis stage 4' within BMC Cancer

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  1. Wilms tumor is the most prevalent embryonal kidney malignancy in children worldwide. Previous genome-wide association study (GWAS) identified that LIM domain only 1 (LMO1) gene polymorphisms affected the suscepti...

    Authors: Wen Fu, Linqing Deng, Xiaosong Yan, Rui-Xi Hua, Jiao Zhang, Haixia Zhou, Changmi Deng, Suhong Li, Jiwen Cheng, Jichen Ruan, Jing He and Guochang Liu
    Citation: BMC Cancer 2024 24:772
    Content type: Research Published on:

  2. A disintegrin and metalloproteinase (ADAMs) have been associated with multiple malignancies. ADAMs are involved in cell fusion, cell migration, membrane protein shedding and proteolysis. ADAM8 has been found t...

    Authors: Valerie Zielinski, Markus Brunner, Gregor Heiduschka, Sven Schneider, Rudolf Seemann, Boban Erovic and Dietmar Thurnher
    Citation: BMC Cancer 2012 12:76
    Content type: Research article Published on:

  3. SMARCB1-deficient sinonasal carcinoma (SDSC) is an aggressive subtype of head and neck cancers that has a poor prognosis despite multimodal therapy. We present a unique case with next generation sequencing dat...

    Authors: Horacio Gomez-Acevedo, John D. Patterson, Sehrish Sardar, Murat Gokden, Bhaskar C. Das, David W. Ussery and Analiz Rodriguez
    Citation: BMC Cancer 2019 19:827
    Content type: Case report Published on:

  4. Insulin-like growth factor-1 receptor (IGF-1R) promotes cell proliferation and migration and inhibitsapoptosis, all of which can contribute to the development of cancers.

    Authors: Wenpeng Cai, Yongfang Ma, Li Song, Niandie Cao, Jiafeng Gao, Shuping Zhou and Xiaolong Tang
    Citation: BMC Cancer 2023 23:87
    Content type: Research Published on:

  5. A-disintegrin and metalloproteinases (ADAMs) are members of a family of multidomain transmembrane and secreted proteins. Specific ADAMs are upregulated in human cancers and correlated with tumor progression an...

    Authors: Xiaodong Jiao, Wenlong Yu, Jianxin Qian, Ying Chen, Peilian Wei, Wenzheng Fang and Guanzhen Yu
    Citation: BMC Cancer 2018 18:570
    Content type: Research article Published on:

  6. High risk human papillomaviruses (HPV) plays important roles in the development of cervical cancer, a number of other anogenital cancer and they are increasingly found in oropharyngeal squamous cell carcinoma ...

    Authors: Ge Gao, Jintu Wang, Jan L. Kasperbauer, Nicole M. Tombers, Fei Teng, Honglan Gou, Yonggang Zhao, Zhenhong Bao and David I. Smith
    Citation: BMC Cancer 2019 19:352
    Content type: Research article Published on:

  7. Chlorella vulgaris (ChV), a unicellular green algae has been reported to have anticancer and antioxidant effects. The aim of this study was to determine the chemopreventive effect of C...

    Authors: Khaizurin Tajul Arifin, Suhaniza Sulaiman, Suhana Md Saad, Hanafi Ahmad Damanhuri, Wan Zurinah Wan Ngah and Yasmin Anum Mohd Yusof
    Citation: BMC Cancer 2017 17:879
    Content type: Research article Published on:

  8. We report on a female patient who underwent primary radical resection for a stage 2B Her-2-positive Barrett’s-type esophageal adenocarcinoma (EAC). Despite Her-2 targeted therapy, her disease recurred and requ...

    Authors: Federica Isidori, Deborah Malvi, Silvia Fittipaldi, Claudio Forcato, Isotta Bozzarelli, Claudia Sala, Giovanni Raulli, Antonia D’Errico, Michelangelo Fiorentino, Marco Seri, Kausilia K. Krishnadath, Elena Bonora and Sandro Mattioli
    Citation: BMC Cancer 2018 18:889
    Content type: Case report Published on:

  9. Several studies on the use of erythropoietin (Epo) to treat anaemia in patients undergoing cancer treatment have shown adverse effects on tumour control and survival. Experimental studies indicate that this co...

    Authors: Gustaf Lindgren, Lars Ekblad, Johan Vallon-Christersson, Elisabeth Kjellén, Maria Gebre-Medhin and Johan Wennerberg
    Citation: BMC Cancer 2014 14:648
    Content type: Research article Published on:

  10. Hepatocellular carcinoma (HCC) is the most common form of liver cancer and the third most lethal cancer worldwide. The epithelial to mesenchymal transition (EMT) describes the transformation of well-differenti...

    Authors: Philipp Wittmann, Markus Grubinger, Christian Gröger, Heidemarie Huber, Wolfgang Sieghart, Markus Peck-Radosavljevic and Wolfgang Mikulits
    Citation: BMC Cancer 2015 15:909
    Content type: Research article Published on:

  12. The CheckMate 025 trial established nivolumab monotherapy as one of the standards of care in previously treated advanced or metastatic renal cell carcinoma (aRCC). However, supporting real-world data is lackin...

    Authors: T. Waddell, K. Fife, R. Griffiths, A. Sharma, P. Dhokia, L. Groves, M. Hurst, C. Tsang, D. Sugrue, S. McKenna, J. Houghton and R. Carroll
    Citation: BMC Cancer 2022 22:617
    Content type: Research Published on:

  13. It is essential to understand the mechanisms responsible for hepatocellular carcinoma (HCC) progression and chemoresistance in order to identify prognostic biomarkers as well as potential therapeutic avenues. ...

    Authors: Lui Ng, Ariel K. M. Chow, Johnny H. W. Man, Thomas C. C. Yau, Timothy M. H. Wan, Deepak N. Iyer, Virginia H. T. Kwan, Ronnie T. P. Poon, Roberta W. C. Pang and Wai-Lun Law
    Citation: BMC Cancer 2018 18:621
    Content type: Research article Published on:

  14. Hepatocellular carcinoma (HCC) is a common cause of cancer mortality worldwide. Recent studies have shown that the polytopic enzyme membrane associated ring-CH-type finger 6 (MARCH6) participates in tumorigene...

    Authors: Jie Sun, Zheng Dong, Zhengyao Chang, Hongfei Liu, Qiyu Jiang, Deyuan Zhang, Shanshan Lu, Xiaodong Jia, Dawei Wu, Aaron Ge, Pan Zhao, Jing Wang and Yinying Lu
    Citation: BMC Cancer 2021 21:827
    Content type: Research article Published on:

  15. Carbonic anhydrase related proteins (CARPs) VIII, X and XI functionally differ from the other carbonic anhydrase (CA) enzymes. Structurally, they lack the zinc binding residues, which are important for enzyme ...

    Authors: Sini L. Karjalainen, Hannu K. Haapasalo, Ashok Aspatwar, Harlan Barker, Seppo Parkkila and Joonas A. Haapasalo
    Citation: BMC Cancer 2018 18:584
    Content type: Research article Published on:

  16. Osteopontin is a secreted phosphoglycoprotein that is expressed by a number of normal cells as well as a variety of tumor cells. With respect to breast cancer, osteopontin has been implicated in regulating tum...

    Authors: S. Saleh, D. E. Thompson, J. McConkey, P. Murray and R. A. Moorehead
    Citation: BMC Cancer 2016 16:359
    Content type: Research article Published on:

  17. Ribonucleases are promising agents for use in anticancer therapy. Among the different ribonucleases described to be cytotoxic, a paradigmatic example is onconase which manifests cytotoxic and cytostatic effect...

    Authors: Jessica Castro, Marc Ribó, Susanna Navarro, Maria Victòria Nogués, Maria Vilanova and Antoni Benito
    Citation: BMC Cancer 2011 11:9
    Content type: Research article Published on:

  18. To examine differences in the plasma levels of miRNA-21, − 214, −34a, and -200a in patients with persistent high-risk human papillomavirus (hr-HPV) infection or with cervical lesions of different grades.

    Authors: Hongyun Wang, Dandan Zhang, Qing Chen and Ying Hong
    Citation: BMC Cancer 2019 19:986
    Content type: Research article Published on:

  19. Malignant pleural effusions (MPE) are a common and fatal complication in cancers including lung or breast cancers, or malignant pleural mesothelioma (MPM). MPE animal models and immunotherapy trials in MPM pat...

    Authors: Arnaud Scherpereel, Bogdan Dragos Grigoriu, Marc Noppen, Thomas Gey, Bachar Chahine, Simon Baldacci, Jacques Trauet, Marie-Christine Copin, Jean-Paul Dessaint, Henri Porte and Myriam Labalette
    Citation: BMC Cancer 2013 13:324
    Content type: Research article Published on:

  20. Long-term locoregional control in locally advanced squamous cell carcinoma of the head and neck (SCCHN) remains challenging. While recent years have seen various approaches to improve outcome by intensificatio...

    Authors: Alexandra D Jensen, Jürgen Krauss, Karin Potthoff, Almaz Desta, Gregor Habl, Athanasios Mavtratzas, Christine Windemuth-Kiesselbach, Jürgen Debus and Marc W Münter
    Citation: BMC Cancer 2011 11:182
    Content type: Study protocol Published on:

  21. Life-threatening cytomegalovirus infection (CMVI) has been reported even in patients with malignant lymphoma (ML) who have not received hematopoietic stem cell transplantation (w/o HSCT) but had been treated w...

    Authors: Kazuya Sato, Sho Igarashi, Nodoka Tsukada, Junki Inamura, Masayo Yamamoto, Motohiro Shindo, Kentaro Moriichi, Yusuke Mizukami, Mikihiro Fujiya and Yoshihiro Torimoto
    Citation: BMC Cancer 2022 22:944
    Content type: Research article Published on:

  22. Molecular differences in colorectal cancer (CRC) are associated with the metastatic route. Patient survival is mainly driven by metastatic spread thus it is imperative to understand its key drivers to develop ...

    Authors: Sven Jacob, Florian Bösch, Markus B. Schoenberg, Elise Pretzsch, Christopher Lampert, Ren Haoyu, Bernhard W. Renz, Marlies Michl, Jörg Kumbrink, Thomas Kirchner, Jens Werner, Martin K. Angele and Jens Neumann
    Citation: BMC Cancer 2021 21:1243
    Content type: Research Published on:

  23. Many studies have combined sorafenib with transcatheter arterial chemoembolization (TACE) to treat patients with advanced hepatocellular carcinoma (HCC), but the results are disputable. Thus, we conducted this...

    Authors: Rong Cai, Rongfeng Song, Pengfei Pang, Yan Yan, Yifeng Liao, Cuiling Zhou, Shuncong Wang, Xiuling Zhou, Huaping Wang, Hongyu Zhang, Huanhuan Sun and Haiqing Ma
    Citation: BMC Cancer 2017 17:714
    Content type: Research article Published on:

  24. Intestinal-type sinonasal adenocarcinomas (ITACs) are aggressive malignancies related to wood dust and leather exposure. ITACs are generally associated with advanced stage at presentation due to the insidious ...

    Authors: Marco Tomasetti, Massimo Re, Federica Monaco, Simona Gaetani, Corrado Rubini, Andrea Bertini, Ernesto Pasquini, Cristiana Bersaglieri, Massimo Bracci, Sara Staffolani, Mariastella Colomba, Armando Gregorini, Matteo Valentino, Adriano Tagliabracci, Massimo Bovenzi, Jiri Neuzil…
    Citation: BMC Cancer 2018 18:896
    Content type: Research article Published on:

  25. Ovarian germ cell tumours (OGCT) are rare but are usually curable with chemotherapy, even when presenting with advanced disease. The majority of OGCT produce the tumour markers, hCG and/or AFP which can be hel...

    Authors: Serena Rakha, Clare Bayliss, Frances Sanderson, Richard Smith, Michael Seckl and Philip Savage
    Citation: BMC Cancer 2010 10:338
    Content type: Case report Published on:

  26. Approximately 40% of colorectal cancer patients will develop colorectal liver metastases (CRLM). The most effective approach to increase long-term survival is CRLM complete resection. Unfortunately, only 10–15...

    Authors: Alice Boilève, Aline Maillard, Mathilde Wagner, Clarisse Dromain, Christophe Laurent, Eric Dupont Bierre, Samuel Le Sourd, Franck Audemar, Ayhan Ulusakarya, Veronique Guerin-Meyer, Denis Smisth, Veronica Pezzella, Thierry De Baere, Diane Goere, Maximiliano Gelli, Julien Taieb…
    Citation: BMC Cancer 2020 20:74
    Content type: Study protocol Published on:

  27. We aimed to evaluate the efficiency and safety of cis/carboplatin plus gemcitabine, which was previously used for mesothelioma but with no recorded proof of its efficiency, compared with cis/carboplatin plus p...

    Authors: Guntulu Ak, Selma Metintas, Muhittin Akarsu and Muzaffer Metintas
    Citation: BMC Cancer 2015 15:510
    Content type: Research article Published on:

  28. Liposarcoma (LPS) is a tumor derived from adipose tissue, and has the highest incidence among soft tissue sarcomas. Dedifferentiated liposarcoma (DDLPS) is a malignant tumor with poor prognosis. Recurrence and...

    Authors: Eun Byeol Jo, Young Sang Lee, Hyunjoo Lee, Jae Berm Park, Hyojun Park, Yoon-La Choi, Doopyo Hong and Sung Joo Kim
    Citation: BMC Cancer 2019 19:496
    Content type: Research article Published on:

  29. Rhabdomyosarcoma (RMS), which can be classified as embryonal RMS (ERMS) and alveolar RMS (ARMS), represents the most frequent soft tissue sarcoma in the pediatric population; the latter shows greater aggressiv...

    Authors: L. Tombolan, E. Poli, P. Martini, A. Zin, C. Millino, B. Pacchioni, B. Celegato, G. Bisogno, C. Romualdi, A. Rosolen and G. Lanfranchi
    Citation: BMC Cancer 2016 16:886
    Content type: Research article Published on:

  30. We assessed the nm23-H1 gene product expression and its relationship with lymphatic and blood vessel invasion in patients with esophageal squamous cell carcinoma.

    Authors: Masaki Tomita, Takanori Ayabe, Yasunori Matsuzaki, Masao Edagawa, Masayuki Maeda, Tetsuya Shimizu, Masaki Hara and Toshio Onitsuka
    Citation: BMC Cancer 2001 1:3
    Content type: Research article Published on:

  31. Eradication of minimal residual disease (MRD), at the end of Fludarabine-Cyclophosphamide-Rituximab (FCR) treatment, is a validated surrogate marker for progression-free and overall survival in chronic lymphoc...

    Authors: Martin Gauthier, Françoise Durrieu, Elodie Martin, Michael Peres, François Vergez, Thomas Filleron, Lucie Obéric, Fontanet Bijou, Anne Quillet Mary and Loic Ysebaert
    Citation: BMC Cancer 2019 19:809
    Content type: Research article Published on:

  32. Extrahepatic Cholangiocarcinoma (EHCC) is one of the uncommon malignancies in the digestive system which is characterized by a poor prognosis. Aberrations of miRNAs have been shown involved in the progression ...

    Authors: Pengfei Qiao, Guodong Li, Wen Bi, Lianmeng Yang, Lei Yao and Dequan Wu
    Citation: BMC Cancer 2015 15:469
    Content type: Research article Published on:

  33. Distant metastases frequently occur in gastroenteropancreatic neuroendocrine tumors. If hepatic surgery is not feasible, patients are treated with somatostatin analogs. However, the underlying mechanisms of ac...

    Authors: Florian Bösch, Alexandr V. Bazhin, Sabine Heublein, Katharina Brüwer, Thomas Knösel, Florian P. Reiter, Christoph J. Auernhammer, Markus O. Guba, Christine Spitzweg, Jens Werner and Martin K. Angele
    Citation: BMC Cancer 2019 19:575
    Content type: Research article Published on:

  34. Targeted drugs are the main methods of RCC treatment. However, drug resistance is common in RCC patients, in-depth study of the drug-resistant mechanism is essential.

    Authors: Fangzhen Cai, Jianwei Li, Yanmei Zhang, Sihuai Huang, Wenbin Liu, Weifeng Zhuo and Chengzhi Qiu
    Citation: BMC Cancer 2024 24:175
    Content type: Research Published on:

  35. Platinum/fluoropyrimidine regimens are the backbone of first-line chemotherapy for advanced gastric cancer (AGC). However response rates to first line chemotherapy range from 30 to 50% and disease progression ...

    Authors: Maria Di Bartolomeo, Monica Niger, Federica Morano, Salvatore Corallo, Maria Antista, Stefano Tamberi, Sara Lonardi, Samantha Di Donato, Rossana Berardi, Mario Scartozzi, Giovanni Gerardo Cardellino, Francesco Di Costanzo, Lorenza Rimassa, Alberto Gianluigi Luporini, Raffaella Longarini, Alberto Zaniboni…
    Citation: BMC Cancer 2019 19:283
    Content type: Study protocol Published on:

  37. Histiocytoses are rare disorders manifested by increased proliferation of pathogenic myeloid cells sharing histological features with macrophages or dendritic cells and accumulating in various organs, i.a., bo...

    Authors: Agnieszka Śmieszek, Klaudia Marcinkowska, Zofia Małas, Mateusz Sikora, Martyna Kępska, Beata A. Nowakowska, Marta Deperas, Marta Smyk, Carlos Rodriguez-Galindo and Anna Raciborska
    Citation: BMC Cancer 2024 24:105
    Content type: Research Published on:

  38. Dysregulated WNT signaling dominates adrenocortical malignancies. This study investigates whether silencing of the WNT negative regulator DKK3 (Dickkopf-related protein 3), an implicated adrenocortical differe...

    Authors: Joyce Y. Cheng, Taylor C. Brown, Timothy D. Murtha, Adam Stenman, C. Christofer Juhlin, Catharina Larsson, James M. Healy, Manju L. Prasad, Wolfram T. Knoefel, Andreas Krieg, Ute I. Scholl, Reju Korah and Tobias Carling
    Citation: BMC Cancer 2017 17:164
    Content type: Research article Published on:

  39. Protein kinase inhibitors (PKIs) are currently tested in clinical studies (phase I-III) as an alternative strategy against (recurrent) ovarian cancer. Besides their anti-tumour efficacy, several PKIs have also...

    Authors: Dennis Lindenblatt, Nastassja Terraneo, Giovanni Pellegrini, Susan Cohrs, Philipp René Spycher, David Vukovic, Martin Béhé, Roger Schibli and Jürgen Grünberg
    Citation: BMC Cancer 2018 18:922
    Content type: Research article Published on:

  40. Since most glioblastomas express both wild-type EGFR and EGFRvIII as well as HER2/neu, they are excellent targets for activated T cells (ATC) armed with bispecific antibodies (BiAbs) that target EGFR and HER2.

    Authors: Ian M Zitron, Archana Thakur, Oxana Norkina, Geoffrey R Barger, Lawrence G Lum and Sandeep Mittal
    Citation: BMC Cancer 2013 13:83
    Content type: Research article Published on:

  41. The architectural transcriptional regulator high-mobility group AT-hook 2 (HMGA2) is an oncofetal protein which has been reported to be ectopically expressed in a variety of cancers. A high expression of HMGA2...

    Authors: Ying Liu, Guangyao Lv, Jianxin Bai, Lingling Song, Elizabeth Ding, Lin Liu, Yuqin Tian, Qian Chen, Kai Li, Xianfeng Liu and Yan Ding
    Citation: BMC Cancer 2022 22:421
    Content type: Research Published on:

  42. Alveolar soft-part sarcoma (ASPS) is an extremely rare, highly vascular soft tissue sarcoma affecting predominantly adolescents and young adults. In an attempt to gain insight into the pathobiology of this eni...

    Authors: Luke H Stockwin, David T Vistica, Susan Kenney, David S Schrump, Donna O Butcher, Mark Raffeld and Robert H Shoemaker
    Citation: BMC Cancer 2009 9:22
    Content type: Research article Published on:

  43. This study explored the attitudes of patients with advanced cancer towards MTP and return of results, prior to undergoing genomic testing within a research program.

    Authors: Megan C. Best, Nicole Bartley, Chris Jacobs, Ilona Juraskova, David Goldstein, Ainsley J. Newson, Jacqueline Savard, Bettina Meiser, Mandy Ballinger, Christine Napier, David Thomas, Barbara Biesecker and Phyllis Butow
    Citation: BMC Cancer 2019 19:753
    Content type: Research article Published on:

  44. Since cholangiocarcinoma has a poor prognosis, several epidermal growth factor receptor (EGFR)-targeted therapies with antibody or small molecule inhibitor treatment have been proposed. However, their effect r...

    Authors: Anping Gui, Akira Kobayashi, Hiroaki Motoyama, Masato Kitazawa, Michiko Takeoka and Shinichi Miyagawa
    Citation: BMC Cancer 2012 12:179
    Content type: Research article Published on:

  45. Cholangiocarcinoma (CCA) may arise in the intra- or extrahepatic biliary tract and is associated with a poor prognosis. Despite recent advances, to date there is still no established targeted therapeutic appro...

    Authors: Mark Kriegsmann, Stephanie Roessler, Katharina Kriegsmann, Marcus Renner, Rémi Longuespée, Thomas Albrecht, Moritz Loeffler, Stephan Singer, Arianeb Mehrabi, Monika Nadja Vogel, Anita Pathil, Bruno Köhler, Christoph Springfeld, Christian Rupp, Karl Heinz Weiss and Benjamin Goeppert
    Citation: BMC Cancer 2019 19:72
    Content type: Research article Published on:

  46. The treatment of recurrent or metastatic head and neck squamous-cell carcinoma (R/M HNSCC) remains challenging. Preclinical studies revealed that B cell depletion could modulate the microenvironment and overco...

    Authors: Ching-Yun Hsieh, Ming-Yu Lien, Chen-Yuan Lin, Wen-Jyi Lo, Chung-Hung Hua, Wei-Chao Chang, Chang-Fang Chiu and Ching-Chan Lin
    Citation: BMC Cancer 2022 22:169
    Content type: Research Published on:

  47. High resolution melting curve analysis is a cost-effective rapid screening method for detection of somatic gene mutation. The performance characteristics of this technique has been explored previously, however...

    Authors: Reenu Anne Joy, Sukrishna Kamalasanan Thelakkattusserry, Narendranath Vikkath, Renjitha Bhaskaran, Sajitha Krishnan, Damodaran Vasudevan and Prasanth S. Ariyannur
    Citation: BMC Cancer 2020 20:902
    Content type: Research article Published on:

  49. Radical radiotherapy is the standard treatment for patients with locally advanced cervix uteri carcinoma (FIGO stage IB2–IVA). Worldwide, incidence and mortality rates vary among regions because of differences...

    Authors: Alparslan Serarslan, Bilge Gursel, Deniz Meydan and Nilgun Ozbek Okumus
    Citation: BMC Cancer 2019 19:1208
    Content type: Research article Published on:

  50. Nuclear protein in testis (NUT) carcinoma (NC) is a rare epithelial malignancy characterized by rearrangement of the NUT gene on chromosome 15. If NC is not suspected, it is often diagnosed as other malignancies....

    Authors: Kohei Arimizu, Gen Hirano, Chinatsu Makiyama, Mioko Matsuo, Takakazu Sasaguri and Akitaka Makiyama
    Citation: BMC Cancer 2018 18:1134
    Content type: Case report Published on:

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