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  1. Endometrial cancer (EC) is the most frequent malignancy of the female genital tract worldwide. Our study aimed to construct an effective protein prognostic signature to predict prognosis and immunotherapy resp...

    Authors: Jinzhi Lai, Tianwen Xu and Hainan Yang
    Citation: BMC Cancer 2022 22:325
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2022 22:480

  2. The prognosis of patients with NSCLC harboring oncogenic driver gene alterations, such as EGFR gene mutations or ALK fusion, has improved dramatically with the advent of corresponding molecularly targeted drugs. ...

    Authors: Shoko Sonobe Shimamura, Takehito Shukuya, Tetsuhiko Asao, Daisuke Hayakawa, Kana Kurokawa, Shiting Xu, Keita Miura, Yoichiro Mitsuishi, Ken Tajima, Rina Shibayama, Naoko Shimada, Fumiyuki Takahashi and Kazuhisa Takahashi
    Citation: BMC Cancer 2022 22:323
    Content type: Research Published on:

  3. The BIRC5 gene encodes for the Survivin protein, which is a member of the inhibitor of apoptosis family. Survivin is found in humans during fetal development, but generally not in adult cells thereafter. Previous...

    Authors: Anna Fäldt Beding, Peter Larsson, Khalil Helou, Zakaria Einbeigi and Toshima Z. Parris
    Citation: BMC Cancer 2022 22:322
    Content type: Research Published on:

  4. Pulmonary neuroendocrine neoplasms can be divided into typical carcinoid, atypical carcinoid, large cell neuroendocrine carcinoma, and small cell (lung) carcinoma. According to the World Health Organization, t...

    Authors: Ying Zhang, Weiya Wang, Qianrong Hu, Zuoyu Liang, Ping Zhou, Yuan Tang and Lili Jiang
    Citation: BMC Cancer 2022 22:321
    Content type: Research Published on:

  5. Targeted therapies for Primary liver cancer (HCC) is limited to the multi-kinase inhibitors, and not fully effective due to the resistance to these agents because of the heterogeneous molecular nature of HCC d...

    Authors: Kubra Narci, Deniz Cansen Kahraman, Altay Koyas, Tulin Ersahin, Nurcan Tuncbag and Rengul Cetin Atalay
    Citation: BMC Cancer 2022 22:320
    Content type: Research Published on:

  6. Some patients diagnosed with cancer use medical cannabis to self-manage undesirable symptoms, including nausea and pain. To improve patient safety and oncological care quality, the routes of administration for...

    Authors: Billy Vinette, José Côté, Ali El-Akhras, Hazar Mrad, Gabrielle Chicoine and Karine Bilodeau
    Citation: BMC Cancer 2022 22:319
    Content type: Research Published on:

  7. To date, Siewert type II adenocarcinoma of the esophagogastric junction (ST-II AEG) can be removed radically utilizing either the abdominal-transhiatal (TH) or the right thoracoabdominal (RTA) approaches. Beca...

    Authors: Qiying Song, Xiongguang Li, Di Wu, Shuo Li, Tianyu Xie, Yixun Lu, Liyu Zhang, Ziyao Xu, Lu Liu, Xin Guo and Xinxin Wang
    Citation: BMC Cancer 2022 22:318
    Content type: Study protocol Published on:

  8. Investigating dynamic changes in blood-parameters and weight in patients with locally advanced non-small cell lung cancer (NSCLC) receiving durvalumab maintenance therapy after chemoradiotherapy (cCRT). Labora...

    Authors: J. Guggenberger, S. Kenndoff, J. Taugner, L. Käsmann, B. Flörsch, C. Belka, C. Eze and F. Manapov
    Citation: BMC Cancer 2022 22:317
    Content type: Research article Published on:

  9. N6-methyladenosine (m6A) modification and long non-coding RNAs (lncRNAs) play pivotal roles in gastric cancer (GC) progression. The emergence of immunotherapy in GC has created a paradigm shift in the approach...

    Authors: Yi Wang, Gui-Qi Zhu, Di Tian, Chang-Wu Zhou, Na Li, Ying Feng and Meng-Su Zeng
    Citation: BMC Cancer 2022 22:316
    Content type: Research Published on:

  11. Colorectal adenoma (CA) is an important precancerous lesion and early screening target of colorectal cancer (CRC). Lipids with numerous physiological functions are proved to be involved in the development of C...

    Authors: Hailin Zhou, Yanying Nong, Yifan Zhu, Yunxiao Liang, Jiahao Zhang, Hongwei Chen, Pingchuan Zhu and Qisong Zhang
    Citation: BMC Cancer 2022 22:314
    Content type: Research Published on:

  12. Bladder cancer (BC) is one of the most common malignant tumors of the urinary system, and cisplatin (CDDP) is a critical chemical drug for the treatment of BC. However, CDDP-resistance seriously limits the the...

    Authors: Ming Sun, Xuefeng Liu, Wenyan Zhao, Bin Zhang and Peng Deng
    Citation: BMC Cancer 2022 22:313
    Content type: Research Published on:

  13. Management of bladder cancer (BLCA) has not changed significantly in the past few decades, with platinum agent chemotherapy being used in most cases. Chemotherapy reduces tumor recurrence after resection, but ...

    Authors: Sayani Bhattacharjee, Matthew J. Sullivan, Rebecca R. Wynn, Alex Demagall, Andrew S. Hendrix, Puneet Sindhwani, Firas G. Petros and Nagalakshmi Nadiminty
    Citation: BMC Cancer 2022 22:312
    Content type: Research Published on:

  14. Immunotherapy has become a new therapy for advanced hepatocellular carcinoma (HCC); however, its treatment results are considerably different. CD4+ T cells (CD4+) are the key to immunotherapy, but patients wit...

    Authors: Yong Zhao, Ling Xiang Kong, Feng Shi Feng, Jiayin Yang and Guo Wei
    Citation: BMC Cancer 2022 22:311
    Content type: Research Published on:

  15. Olanzapine has been reported to be an effective antiemetic in patients receiving carboplatin-based chemotherapy. However, the efficacy of a neurokinin-1 receptor antagonist (NK1RA) added to olanzapine, a 5-hydrox...

    Authors: Senri Yamamoto, Hirotoshi Iihara, Ryuji Uozumi, Hitoshi Kawazoe, Kazuki Tanaka, Yukiyoshi Fujita, Masakazu Abe, Hisao Imai, Masato Karayama, Yoh Hayasaki, Chiemi Hirose, Takafumi Suda, Kazuto Nakamura, Akio Suzuki, Yasushi Ohno, Ken-ichirou Morishige…
    Citation: BMC Cancer 2022 22:310
    Content type: Research Published on:

  16. Women’s perception and knowledge of breast cancer signs, symptoms, and risk factors could be conducive to breast cancer risk management and interventions. The present study aimed to explore Iranian laywomen pe...

    Authors: E. Manouchehri, A. Taghipour, A. Ebadi, F. Homaei Shandiz and R. Latifnejad Roudsari
    Citation: BMC Cancer 2022 22:309
    Content type: Research Published on:

  20. Breast cancer screening and improving imaging techniques have led to an increase in the detection rate of early, nonpalpable breast cancers. For early breast cancer, breast conserving surgery is an effective a...

    Authors: Bianca M. den Dekker, Anke Christenhusz, Thijs van Dalen, Lisa M. Jongen, Margreet C. van der Schaaf, Anneriet E. Dassen and Ruud M. Pijnappel
    Citation: BMC Cancer 2022 22:305
    Content type: Study protocol Published on:

  21. Second-generation androgen receptor inhibitors (ARIs) have been associated with adverse events (AEs) such as fatigue, falls, fractures, and rash in non-metastatic castration-resistant prostate cancer (nmCRPC) ...

    Authors: Arif Hussain, Shan Jiang, Della Varghese, Sreevalsa Appukkuttan, Nehemiah Kebede, Kajan Gnanasakthy, Cynthia Macahilig, Reg Waldeck and Shelby Corman
    Citation: BMC Cancer 2022 22:304
    Content type: Research Published on:

  23. Few studies have addressed colon cancer surgery outcomes in an unselected cohort of octogenarian patients. The present study aimed to evaluate the relative survival of octogenarian patients after a major resec...

    Authors: Øystein Høydahl, Tom-Harald Edna, Athanasios Xanthoulis, Stian Lydersen and Birger Henning Endreseth
    Citation: BMC Cancer 2022 22:302
    Content type: Research Published on:

  24. The optimal radiation dose for treating non-metastatic superficial esophageal squamous cell carcinoma is unknown. In this retrospective observational study, we investigated the influence of radiation dose and ...

    Authors: Toshiki Ikawa, Ryu Ishihara, Katsunori Matsueda, Koji Konishi, Sachiko Yamamoto, Masahiro Morimoto, Naoyuki Kanayama and Teruki Teshima
    Citation: BMC Cancer 2022 22:301
    Content type: Research Published on:

  25. Well-differentiated and dedifferentiated liposarcomas are rare soft tissue tumors originating in adipose tissue that share genetic abnormalities but have significantly different metastatic potential. Dediffere...

    Authors: Thanh N. Dang, Rafael P. Tiongco, Loren M. Brown, Jessica L. Taylor, John M. Lyons, Frank H. Lau and Z. Elizabeth Floyd
    Citation: BMC Cancer 2022 22:300
    Content type: Research Published on:

  26. Lung cancer is the most common malignant tumor, and it has a high mortality rate. However, the study of miRNA-mRNA regulatory networks in the plasma of patients with non-small cell lung cancer (NSCLC) is insuf...

    Authors: Wei Zhang, Qian Zhang, Li Che, Zhefan Xie, Xingdong Cai, Ling Gong, Zhu Li, Daishun Liu and Shengming Liu
    Citation: BMC Cancer 2022 22:299
    Content type: Research Published on:

  28. ITPR1 is a key gene for autophagy, but its biological function is still unclear, and there are few studies on the correlation between ITPR1 gene expression and the occurrence and development of breast cancer.

    Authors: Bing Han, Fang Zhen, Xiu-Shuang Zheng, Jing Hu and Xue-Song Chen
    Citation: BMC Cancer 2022 22:297
    Content type: Research Published on:

  29. The incidence of human papillomavirus (HPV) positive oropharyngeal cancer (OPC) is rising but HPV negative OPC is decreasing in Western countries. In Taiwan, the incidence of HPV negative OPC is common but the...

    Authors: Cheng-Ping Wang, Tseng-Cheng Chen, Wan-Lun Hsu, Jenn-Ren Hsiao, Peir-Rong Chen, Mu-Kuan Chen, Chun-Hung Hua, Ming-Hsui Tsai, Jenq-Yuh Ko, Pei-Jen Lou, Chun-Ju Chiang, Chen-Tu Wu and Yih-Leong Chang
    Citation: BMC Cancer 2022 22:296
    Content type: Research Published on:

  30. Breast cancer (BC) is the most common cancer among women. Studies have shown that cancer patients can develop depression impacting their quality of life, treatment outcomes, and survival rates. This study aime...

    Authors: Dana Sadaqa, Ahlam Farraj, Hani Naseef, Hamza Alsaid, Nimeh Al-Shami and Abdallah Damin AbuKhalil
    Citation: BMC Cancer 2022 22:295
    Content type: Research Published on:

  31. Dacomitinib is a second-generation, irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). ARCHER-1050 showed that this agent can improve progression-free survival and overall surv...

    Authors: Bo Zhang, Chunlei Shi, Zhiqiang Gao, Hua Zhong, Liwen Xiong, Aiqin Gu, Weimin Wang, Tianqing Chu, Wei Zhang, Huimin Wang, Xueyan Zhang, Runbo Zhong and Baohui Han
    Citation: BMC Cancer 2022 22:294
    Content type: Study protocol Published on:

  32. This study aimed to evaluate the efficiency and prognostic factors of lenvatinib plus programmed death 1 (PD-1) blockades in patients with advanced hepatocellular carcinoma (HCC), especially for those with tum...

    Authors: Xuqi Sun, Qi Zhang, Jie Mei, Ziliang Yang, Minshan Chen and Tingbo Liang
    Citation: BMC Cancer 2022 22:293
    Content type: Research Published on:

  33. Detection of the ROS1 rearrangement is mandatory in patients with advanced or metastatic non-small cell lung cancer (NSCLC) to allow targeted therapy with specific inhibitors. However, in Spanish clinical practic...

    Authors: Federico Rojo, Esther Conde, Héctor Torres, Luis Cabezón-Gutiérrez, Dolores Bautista, Inmaculada Ramos, David Carcedo, Natalia Arrabal, J. Francisco García, Raquel Galán and Ernest Nadal
    Citation: BMC Cancer 2022 22:292
    Content type: Research Published on:

  34. Traumatic brain injury (TBI) has been reported as a risk factor for brain cancer development. However, the magnitude of the impact of TBI on systemic cancer development has not been clarified.

    Authors: Chung-Che Lu, Tee-Tau Eric Nyam, Chung-Han Ho, Jinn-Rung Kuo, Chung-Ching Chio, Jhi-Joung Wang and Che-Chuan Wang
    Citation: BMC Cancer 2022 22:291
    Content type: Research Published on:

  35. Colorectal cancer (CRC) is the third most prevalent cancer in the world, which remains one of the leading causes of cancer-related deaths. Accurate prognosis prediction of CRC is pivotal to reduce the mortalit...

    Authors: Yiding Li, Guiling Wu, Yujie Zhang, Ben Han, Wanli Yang, Xiaoqian Wang, Lili Duan, Liaoran Niu, Junfeng Chen, Wei Zhou, Jinqiang Liu, Daiming Fan and Liu Hong
    Citation: BMC Cancer 2022 22:290
    Content type: Research Published on:

  36. Pheochromocytomas (PCC) and paragangliomas (PGL) are catecholamine-producing neuroendocrine tumors. According to the World Health Organization Classification 2017, all PCC/PGL are considered to have malignant ...

    Authors: Takao Kamai, Satoshi Murakami, Kyoko Arai, Daisaku Nishihara, Toshitaka Uematsu, Kazuyuki Ishida and Toshiki Kijima
    Citation: BMC Cancer 2022 22:289
    Content type: Research Published on:

  37. Osteosarcoma (OS) is one of the most common primary bone malignant tumors. Osteoclasts have been shown to have a valuable role in OS. In the present study, we analyzed the differentiation states of osteoclasts...

    Authors: Haiyu Shao, Meng Ge, Jun Zhang, Tingxiao Zhao and Shuijun Zhang
    Citation: BMC Cancer 2022 22:288
    Content type: Research Published on:

  38. Long-term antiviral treatments are associated with a significantly lower hepatocellular carcinoma (HCC) incidence in chronic hepatitis B (CHB) patients by reducing HBV DNA concentrations. However, it is still ...

    Authors: Ze-Hong Huang, Gui-Yang Lu, Ling-Xian Qiu, Guo-Hua Zhong, Yue Huang, Xing-Mei Yao, Xiao-Hui Liu, Shou-Jie Huang, Ting Wu, Quan Yuan, Ying-Bin Wang, Ying-Ying Su, Jun Zhang and Ning-Shao Xia
    Citation: BMC Cancer 2022 22:287
    Content type: Research Published on:

  39. MDT discussion is the gold standard for cancer care in the UK. With the incidence of cancer on the rise, demand for MDT discussion is increasing. The need for efficiency, whilst maintaining high standards, is ...

    Authors: George T. F. Brown, Hilary L. Bekker and Alastair L. Young
    Citation: BMC Cancer 2022 22:286
    Content type: Research Published on:

  40. Response guided treatment in breast cancer is highly desirable, but the effectiveness is only established based on residual cellularity from histopathological analysis after surgery. Tubule formation, a key co...

    Authors: Kwok-Shing Chan, Sai Man Cheung, Nicholas Senn, Ehab Husain, Yazan Masannat, Steven Heys and Jiabao He
    Citation: BMC Cancer 2022 22:285
    Content type: Research Published on:

  41. It has been reported that Osaka prognostic score (OPS), based on C-reactive protein (CRP), total lymphocyte counts (TLC) and albumin (ALB), was relevant to prognosis in colorectal cancer. However, the role of ...

    Authors: Jifeng Feng, Lifen Wang, Liang Wang, Xun Yang and Guangyuan Lou
    Citation: BMC Cancer 2022 22:284
    Content type: Research Published on:

  42. Prostate cancer is the most common internal malignancy in Australian men, and although most patients have good survival outcomes, treatment toxicities can impair function, leading to diminished quality of life...

    Authors: Kendrick Koo, Nathan Papa, Melanie Evans, Michael Jefford, Maarten IJzerman, Victoria White, Sue M. Evans, Eli Ristevski, Jon Emery and Jeremy Millar
    Citation: BMC Cancer 2022 22:283
    Content type: Research Published on:

  43. Although targeting of the cholesterol pathway by statins prevents breast cancer development in mouse models, efficacy is not absolute. Therefore, the goal of this study is to investigate if the upregulation in...

    Authors: Anjana Bhardwaj, Matthew D. Embury, Zhenlin Ju, Jing Wang and Isabelle Bedrosian
    Citation: BMC Cancer 2022 22:282
    Content type: Research Published on:

  44. In cancer survival analyses using population-based data, researchers face the challenge of ascertaining the timing of recurrence. We previously developed algorithms to identify recurrence of breast cancer. Thi...

    Authors: Hyunmin Jung, Mingshan Lu, May Lynn Quan, Winson Y. Cheung, Shiying Kong, Sasha Lupichuk, Yuanchao Feng and Yuan Xu
    Citation: BMC Cancer 2022 22:281
    Content type: Research Published on:

  45. Gastric cancer (GC) is one of the most common malignancies, and the liver is the most common site of hematogenous metastasis of GC. AMIGO2 is a type I transmembrane protein that has been implicated in tumour c...

    Authors: Keisuke Goto, Masaki Morimoto, Mitsuhiko Osaki, Akimitsu Tanio, Runa Izutsu, Yoshiyuki Fujiwara and Futoshi Okada
    Citation: BMC Cancer 2022 22:280
    Content type: Research Published on:

  47. Treatment decision for recurrent symptomatic brain metastases (BM) is challenging with scarce data regarding surgical resection. We therefore evaluated the efficacy of surgery for pretreated, recurrent BM in a...

    Authors: Nadine Heßler, Stephanie T. Jünger, Anna-Katharina Meissner, Martin Kocher, Roland Goldbrunner and Stefan Grau
    Citation: BMC Cancer 2022 22:275
    Content type: Research article Published on:

  48. For patients with locally advanced (T3-4/N +) rectal cancer (LARC), the standard treatment is neoadjuvant chemoradiotherapy combined with total mesorectal resection, which greatly decreases local recurrence bu...

    Authors: Yaqi Wang, Lijun Shen, Juefeng Wan, Hui Zhang, Ruiyan Wu, Jingwen Wang, Yan Wang, Ye Xu, Sanjun Cai, Zhen Zhang and Fan Xia
    Citation: BMC Cancer 2022 22:274
    Content type: Study protocol Published on:

  50. Despite significant survival improvement in human epidermal growth factor receptor 2 (HER2) blockade for HER2-positive breast cancer, resistance to anti-HER2 remains inevitable. Subsequent anti-HER2 with conti...

    Authors: Fangfang Duan, Muyi Zhong, Yuyu Ma, Chenge Song, Lehong Zhang, Ying Lin, Zhiyong Wu, Yuanqi Zhang, Jiajia Huang, Fei Xu, Yanxia Shi, Shusen Wang, Zhongyu Yuan, Wen Xia and Xiwen Bi
    Citation: BMC Cancer 2022 22:271
    Content type: Research Published on:

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