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Correction: Protein-based prognostic signature for predicting the survival and immunotherapeutic efficiency of endometrial carcinoma

The Original Article was published on 25 March 2022

Correction: BMC Cancer 22, 325 (2022)

https://doi.org/10.1186/s12885-022-09402-w

Following publication of the original article [1], an error was identified regarding the order of Figs. 5, 6, 7, 8, 9 and 10.

  • Fig. S3 was incorrectly published as Fig. 5.

  • Fig. 5 was incorrectly published as Fig. 6.

  • Fig. 6 was incorrectly published as Fig. 7.

  • Fig. 7 was incorrectly published as Fig. 8.

  • Fig. 8 was incorrectly published as Fig. 9.

  • Fig. 9 was incorrectly published as Fig. 10.

  • We missed to upload the corrected version of Fig. 10 when we proofed this article. Fig. 10 has been corrected to maintain the integrity of our article.

Fig. 5
figure 1

The relationship between 9 prognostic proteins, the risk score and clinical characteristics. a The scatter plot shows the correlation between the risk score and tumor stages. b The scatter plot shows the correlation between risk score and tumor grade. c The expression of EPPK1, p16INK4a, Annexin 1 and Myosin IIA was related to age in EC patients. d The expression of ER-alpha, Annexin 1, Chk2-pT68 and p16INK4a was significantly associated with cancer stage. e Sankey diagram of all proteins related to 9 proteins in the TCPA database (correlation coefficient > 0.4) (p < 0.001). (F) The corelationship of 9 proteins in the prognostic signature. * p < 0.05, ** p < 0.01, *** p < 0.001

Fig. 6
figure 2

The relationship between 9 prognostic proteins, the risk score and clinical characteristics. a Protein level of prognostic proteins in EC tumor tissues and normal tissues. b Representative protein expression levels of ER-alpha, PR, Annexin 1, Chk2-pT68, EPPK1, p16INK4a and ASNS explored in the HPA database. c IHC staining data of ER-alpha and PR expression levels from 100 clinical samples in our hospital. * p < 0.05, ** p < 0.01, *** p < 0.001

Fig. 7
figure 3

Association of the prognostic signature and tumor infiltrating immune cells. a Violin plot comparing the proportions of immune cells between the high-risk and low-risk groups. b Survival curves obtained by the Kaplan–Meier method indicated that high proportions of CD8 T cells, T follicular helper cells and regulatory T cells were significantly associated with prolonged OS. c Correlation matrix of 22 immune cells and the risk score system

Fig. 8
figure 4

Association of the prognostic signature with TMB and MSI status. a Summary of the overall mutation profile of EC patients. b The scatter plot shows the correlation between the risk score and TMB value of EC patients. c Violin plot of the association of MSI status and risk score. d Kaplan–Meier curves showed that MSI-H patients had a favorable prognosis in EC patients

Fig. 9
figure 5

The low-risk group may be more sensitive to immunotherapies. a The differences in response results to immunotherapy between low-risk and high-risk groups. b The scatter plot shows the correlation between immunotherapy responsiveness and risk score in EC patients. c The relative probabilities of responding to anti-CTLA-4 antibody in the low-risk and high-risk groups. d The relative probabilities of responding to anti-PD-1/PD-L1 antibody in the low-risk and high-risk groups

Fig. 10
figure 6

a Evaluation of the sensitivity of chemotherapy drugs between the high-risk and low-risk groups based on the IC50 values of paclitaxel, cisplatin and doxorubicin for EC patients. b Differences in molecular drug sensitivity between the high-risk and low-risk groups based on IC50 values of AKT inhibitor VIII, VEGFR inhibitor (pazopanib) and mTOR inhibitor (temsirolimus)

The correct versions of Figs. 5, 6, 7, 8, 9 and 10 are given in this correction article. The original article [1] has been corrected.

Reference

  1. Lai J, Xu T, Yang H. Protein-based prognostic signature for predicting the survival and immunotherapeutic efficiency of endometrial carcinoma. BMC Cancer. 2022;22:325. https://doi.org/10.1186/s12885-022-09402-w.

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Correspondence to Tianwen Xu or Hainan Yang.

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Lai, J., Xu, T. & Yang, H. Correction: Protein-based prognostic signature for predicting the survival and immunotherapeutic efficiency of endometrial carcinoma. BMC Cancer 22, 480 (2022). https://doi.org/10.1186/s12885-022-09517-0

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  • DOI: https://doi.org/10.1186/s12885-022-09517-0