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3909 result(s) for 'lung cancer prognosis stage 4' within BMC Cancer

Page 53 of 79

  1. Targeting Protein for Xenopus Kinesin Like Protein 2 (TPX2) is a microtubule associated protein that functions in mitotic spindle assembly. TPX2 also localizes to the nucleus where it functions in DNA damage r...

    Authors: Daniel R. Matson, Ryan A. Denu, Lauren M. Zasadil, Mark E. Burkard, Beth A. Weaver, Christopher Flynn and P. Todd Stukenberg
    Citation: BMC Cancer 2021 21:186
    Content type: Research article Published on:

  2. Tumour relapse is recognized to be the prime fatal burden in patients affected by head and neck squamous cell carcinoma (HNSCC), but no discrete molecular trait has yet been identified to make reliable early p...

    Authors: Anna Farnedi, Silvia Rossi, Nicoletta Bertani, Mariolina Gulli, Enrico Maria Silini, Maria Teresa Mucignat, Tito Poli, Enrico Sesenna, Davide Lanfranco, Lucio Montebugnoli, Elisa Leonardi, Claudio Marchetti, Renato Cocchi, Andrea Ambrosini-Spaltro, Maria Pia Foschini and Roberto Perris
    Citation: BMC Cancer 2015 15:352
    Content type: Research article Published on:

  3. The study is to evaluate the patterns of failure, toxicities and long-term outcomes of aggressive treatment using 18F-FDG PET/CT-guided chemoradiation plannings for advanced cervical cancer with extensive nodal e...

    Authors: Yih-Lin Chung, Cheng-Fang Horng, Pei-Ing Lee and Fong-Lin Chen
    Citation: BMC Cancer 2016 16:179
    Content type: Research article Published on:

  4. We compared the clinical characteristics and survival outcomes after radical radiotherapy between nasopharyngeal carcinoma (NPC) with early and late metastases based on a relatively large cohort, which provide...

    Authors: Guo-Dong Jia, Xue-Song Sun, Xiao-Yun Li, Sai-Lan Liu, Jin-Hao Yang, Qiu-Yan Chen, Li Yuan and Hai-Qiang Mai
    Citation: BMC Cancer 2023 23:7
    Content type: Research Published on:

  5. The diagnostic and prognostic significance of increased cathepsin B (CTSB) and cathepsin D (CTSD) concentration in the serum of cancer patients were evaluated for some tumor types. High expression of CTSD and ...

    Authors: Gongjun Tan, Qianxu Liu, Xiaowei Tang, Ting Kang, Yuejin Li, Jinping Lu, Xiaoming Zhao and Faqing Tang
    Citation: BMC Cancer 2016 16:241
    Content type: Research article Published on:

  6. The downregulation of microRNA (miR)-451a has been reported in bladder cancer (BCa) tissues. Herein, we elucidated the role of miR-451a in BCa with the involvement of DNA methyltransferase 3B (DNMT3B).

    Authors: Beibei Liu, Wei Sun, Wuyue Gao, Liqiang Li, Zhenxue Cao, Xiaohuai Yang, Jianmin Liu and Yuanyuan Guo
    Citation: BMC Cancer 2020 20:1019
    Content type: Research article Published on:

  7. Bone morphogenetic protein-6 (BMP-6) is critically involved in many developmental processes. Recent studies indicate that BMP-6 is closely related to tumor differentiation and metastasis.

    Authors: Shuang Yang, Jun Du, Zhaoqi Wang, Wei Yuan, Yuhuan Qiao, Ming Zhang, Jie Zhang, Songyuan Gao, Jian Yin, Baocun Sun and Tianhui Zhu
    Citation: BMC Cancer 2007 7:211
    Content type: Research article Published on:

  8. Matricellular glycoprotein, SPARC is a secreted molecule, that mediates the interaction between cells and extracellular matrix. SPARC functions as a regulator of matrix organization and modulates cell behavior...

    Authors: Sachiko Yoshida, Kazuo Asanoma, Hiroshi Yagi, Ichiro Onoyama, Emiko Hori, Yumiko Matsumura, Kaoru Okugawa, Hideaki Yahata and Kiyoko Kato
    Citation: BMC Cancer 2021 21:156
    Content type: Research article Published on:

  9. EGFR and ALK alternations often contribute to human malignancies, including lung cancer. EGFR and ALK mutations are usually sensitive to EGFR-tyrosine kinase inhibitors (TKIs) and ALK-TKIs. Although generally ...

    Authors: Xiaodan Yang, Jia Zhong, Zhuo Yu, Minglei Zhuo, Min Zhang, Rongrong Chen, Xuefeng Xia and Jun Zhao
    Citation: BMC Cancer 2021 21:1107
    Content type: Research article Published on:

  10. Cisplatin-based chemotherapy, in combination with fluoropyrimidines or taxanes, have demonstrated efficacy against advanced gastric cancer (AGC). This retrospective study was performed with the data obtained f...

    Authors: Do Hyoung Lim, Se Hoon Park, Keon Woo Park, Jung Hun Kang, Sung Yong Oh, In Gyu Hwang, Jung Mi Kwon, Sang-Cheol Lee, Hui-Young Lee, Hyeong Su Kim, Ho Yeong Lim and Won Ki Kang
    Citation: BMC Cancer 2010 10:583
    Content type: Research article Published on:

  11. Thrombospondin1 (THBS1), cystene-rich protein 61 (Cyr61) and connective tissue growth factor (CTGF) are all involved in the transforming growth factor-beta (TGF-β) signal pathway, which plays an important role...

    Authors: Zhu-Qing Zhou, Wei-Hua Cao, Jian-Jun Xie, Jing Lin, Zhong-Ying Shen, Qing-Ying Zhang, Jin-Hui Shen, Li-Yan Xu and En-Min Li
    Citation: BMC Cancer 2009 9:291
    Content type: Research article Published on:

  12. Bladder cancer is the tenth most common cancer worldwide. For patients with T1 high-grade or T2 bladder cancer, radical cystectomy is recommended. However, radical cystectomy is associated with various complic...

    Authors: Xiangwei Yang, Shiqiang Zhang, Yajiao Cui, Yamei Li, Xinyue Song and Jun Pang
    Citation: BMC Cancer 2023 23:320
    Content type: Study Protocol Published on:

  13. The heat shock protein 90 (Hsp90) is required for the stability of many signalling kinases. As a target for cancer therapy it allows the simultaneous inhibition of several signalling pathways. However, its inh...

    Authors: Armin Haupt, Gerard Joberty, Marcus Bantscheff, Holger Fröhlich, Henning Stehr, Michal R Schweiger, Axel Fischer, Martin Kerick, Stefan T Boerno, Andreas Dahl, Michael Lappe, Hans Lehrach, Cayetano Gonzalez, Gerard Drewes and Bodo MH Lange
    Citation: BMC Cancer 2012 12:38
    Content type: Research article Published on:

  14. HtrA1 is expressed in a variety of normal human tissues and seems to be involved in numerous physiological processes as well as tumorigenesis. This study reports the results of a meta-analysis that was perform...

    Authors: Emma Altobelli, Paolo Matteo Angeletti, Manrico Morroni and Valerio Filippo Profeta
    Citation: BMC Cancer 2018 18:143
    Content type: Research article Published on:

  15. Cervical cancer (CC) is the fourth cause of mortality by neoplasia in women worldwide. The use of immunomarkers is an alternative tool to complement currently used algorithms for detection of cancer, and to im...

    Authors: Ana E. Zacapala-Gómez, Napoleón Navarro-Tito, Luz del C. Alarcón-Romero, Carlos Ortuño-Pineda, Berenice Illades-Aguiar, Eduardo Castañeda-Saucedo, Julio Ortiz-Ortiz, Olga L. Garibay-Cerdenares, Marco A. Jiménez-López and Miguel A. Mendoza-Catalán
    Citation: BMC Cancer 2018 18:349
    Content type: Research article Published on:

  16. Sarcoid-like reaction is often seen in various types of carcinoma, not only in the primary tumor, but also in regional lymph nodes, and can occur at any time, not only at the time of diagnosis, but also after ...

    Authors: Yota Kawasaki, Kosei Maemura, Hiroshi Kurahara, Yuko Mataki, Satoshi Iino, Masahiko Sakoda, Shinichi Ueno, Hiroyuki Shinchi, Sonshin Takao and Shoji Natsugoe
    Citation: BMC Cancer 2014 14:946
    Content type: Case report Published on:

  17. Real-world data of Palbociclib are insufficient in China. This study aimed to investigate the treatment pattern and real-world outcomes in hormone receptor positive and human epidermal growth factor 2 receptor...

    Authors: Jiao Yang, Bing Zhao, Xiaoling Ling, Donghui Li, Jiuda Zhao, Yonggang Lv, Guangxi Wang, Xinlan Liu, Nanlin Li and Jin Yang
    Citation: BMC Cancer 2023 23:103
    Content type: Research Published on:

  18. Previous studies showed sanguinarine induced apoptosis in CRC cells but did not define the underlying mechanisms. The purpose of this work was to determine the in vivo and in vitro effects of sanguinarine on C...

    Authors: Xianling Gong, Zhihong Chen, Qinrui Han, Chunhui Chen, Linlin Jing, Yawei Liu, Liang Zhao, Xueqing Yao and Xuegang Sun
    Citation: BMC Cancer 2018 18:578
    Content type: Research article Published on:

  19. Hepatitis B virus (HBV) infections is an important public health problem worldwide and closely affect extrahepatic cancer. Several recent studies have investigated the relationship between HBV infection and he...

    Authors: Rukeng Tan, Xinyu Zhu, Yutong Sun, Shihao Yang, Chao Peng, Xinkai Feng, Zengyu Chen, Yiliyaer Yimamu, Guiqing Liao and Le Yang
    Citation: BMC Cancer 2024 24:225
    Content type: Research Published on:

  20. We aimed to investigate response and prognostic factors in patients with human epidermal growth factor receptor 2 (HER2) positive metastatic colorectal cancer (mCRC) and compare the curative effect on patients...

    Authors: Liu Yang, Wenfei Li, Zhihao Lu, Ming Lu, Jun Zhou, Zhi Peng, Xiaotian Zhang, Xicheng Wang, Lin Shen and Jian Li
    Citation: BMC Cancer 2022 22:355
    Content type: Research Published on:

  21. In recent years, an increasing number of studies have revealed that patients’ preoperative inflammatory response, coagulation function, and nutritional status are all linked to the occurrence, development, ang...

    Authors: Xiaozong Duan, Bo Yang, Chengbin Zhao, Boran Tie, Lei Cao and Yuyuan Gao
    Citation: BMC Cancer 2023 23:432
    Content type: Research Published on:

  22. The development of new therapeutic strategies for treatment of metastasized colorectal carcinoma requires biologically relevant and adequate animal models that generate both reproducible metastasis and the dis...

    Authors: Andreas Thalheimer, Christoph Otto, Marco Bueter, Bertram Illert, Stefan Gattenlohner, Martin Gasser, Detlef Meyer, Martin Fein, Christoph T Germer and Ana M Waaga-Gasser
    Citation: BMC Cancer 2009 9:29
    Content type: Research article Published on:

  23. To evaluate the effect of regorafenib on soluble MHC class I polypeptide-related sequence A (MICA) (sMICA) level in vitro. In addition, we clinically examined whether its plasma levels were associated with reg...

    Authors: Jun Arai, Yumi Otoyama, Ken-ichi Fujita, Kaku Goto, Masayuki Tojo, Atsushi Katagiri, Hisako Nozawa, Yutaro Kubota, Takehiro Takahashi, Hiroo Ishida, Takuya Tsunoda, Natsumi Matsumoto, Keita Ogawa, Ryo Nakagawa, Ryosuke Muroyama, Naoya Kato…
    Citation: BMC Cancer 2022 22:428
    Content type: Research Published on:

  24. Neoadjuvant chemotherapy (NAC) using platinum and irinotecan (CPT-11) followed by radical excision has been shown to be a valid treatment for locally advanced squamous cervical cancer (SCC) patients. However, ...

    Authors: Naoki Horikawa, Tsukasa Baba, Noriomi Matsumura, Ryusuke Murakami, Kaoru Abiko, Junzo Hamanishi, Ken Yamaguchi, Masafumi Koshiyama, Yumiko Yoshioka and Ikuo Konishi
    Citation: BMC Cancer 2015 15:739
    Content type: Research article Published on:

  26. Trabectedin in combination with pegylated liposomal doxorubicin (PLD) is approved for the treatment of patients with platinum-sensitive relapsed ovarian cancer. Nevertheless, there is currently limited informa...

    Authors: María Jesús Rubio, Aránzazu Manzano, Luis Miguel de Sande, Purificación Estévez-García, María del Mar Gordon, Diego Soto de Prado, Blanca Hernando Fernández de Aranguiz, Eva M. Guerra-Alia, Anna Carbó-Bagué, Ignacio Romero, Miguel Corbellas, Alba González-Haba, Carlos E. Robles-Barraza, Jerónimo Martínez-García and Antonio González-Martín
    Citation: BMC Cancer 2024 24:803
    Content type: Research Published on:

  28. Aldehyde dehydrogenases belong to a superfamily of detoxifying enzymes that protect cells from carcinogenic aldehydes. Of the superfamily, ALDH1A1 has gained most attention because current studies have shown t...

    Authors: Yu-Ting Saw, Junzheng Yang, Shu-Kay Ng, Shubai Liu, Surendra Singh, Margit Singh, William R Welch, Hiroshi Tsuda, Wing-Ping Fong, David Thompson, Vasilis Vasiliou, Ross S Berkowitz and Shu-Wing Ng
    Citation: BMC Cancer 2012 12:329
    Content type: Research article Published on:

  29. The heat shock proteins (HSPs) 27-kDa (HSP27) and 72-kDa (HSP72), are ubiquitous chaperone molecules inducible in cells exposed to different stress conditions. Increased level of HSPs are reported in several h...

    Authors: Antonello A Romani, Pellegrino Crafa, Silvia Desenzani, Gallia Graiani, Costanza Lagrasta, Mario Sianesi, Paolo Soliani and Angelo F Borghetti
    Citation: BMC Cancer 2007 7:232
    Content type: Research article Published on:

  31. The Wnt/β-catenin signaling pathway plays an important role in embryogenesis and tumorigenesis. In human cancer, abnormal activity of Wnt/β-catenin signaling pathway induces overexpressed of downstream genes, ...

    Authors: Hung-Wen Tsai, Shu-Wen Cheng, Chou-Cheng Chen, I-Wen Chen and Chung-Liang Ho
    Citation: BMC Cancer 2023 23:1025
    Content type: Research Published on:

  32. Cancer invasion and metastasis develops through a series of steps that involve the loss of cell to cell and cell to matrix adhesion, degradation of extracellular matrix and induction of angiogenesis. Different...

    Authors: Ge Zhang, Makito Miyake, Adrienne Lawton, Steve Goodison and Charles J Rosser
    Citation: BMC Cancer 2014 14:310
    Content type: Research article Published on:

  33. Prostate-specific membrane antigen (PSMA) overexpression has been observed in the endothelial neovasculature of several solid malignancies. This study aimed to identify PSMA expression in the primary tumor of ...

    Authors: Young Jae Ryu, Soo Young Lim, Yong Min Na, Min Ho Park, Seong Young Kwon and Ji Shin Lee
    Citation: BMC Cancer 2022 22:1278
    Content type: Research Published on:

  35. Pancreatic cancer, a highly fatal malignancy, has shown a global rise in the incidence and mortality rates. However, these rates vary significantly across different regions worldwide. This study aims to assess...

    Authors: Nasr Eldin Elwali, Saad Mohammed AlShareef, Ammar H. Khamis and Moawia M. A. Elhassan
    Citation: BMC Cancer 2024 24:653
    Content type: Research Published on:

  36. Drug resistance is a major challenge in cancer therapeutics. Abundant evidence indicates that DNA repair systems are enhanced after repetitive chemotherapeutic treatments, rendering cancers cells drug-resistan...

    Authors: Jianwei Wang, Lina Zhou, Zhi Li, Ting Zhang, Wenpeng Liu, Zheng Liu, Yate-Ching Yuan, Fan Su, Lu Xu, Yan Wang, Xiaotong Zhou, Hong Xu, Yuejin Hua, Ying-Jie Wang, Li Zheng, Yue-E Teng…
    Citation: BMC Cancer 2015 15:50
    Content type: Research article Published on:

  37. The machine learning models with dose factors and the deep learning models with dose distribution matrix have been used to building lung toxics models for radiotherapy and achieve promising results. However, f...

    Authors: Liming Sheng, Lei Zhuang, Jing Yang, Danhong Zhang, Ying Chen, Jie Zhang, Shengye Wang, Guoping Shan, Xianghui Du and Xue Bai
    Citation: BMC Cancer 2023 23:988
    Content type: Research Published on:

  38. In this retrospective study, we evaluated the biochemical recurrence rate, metastatic disease progression, and prostate cancer-specific and overall survival in patients curatively treated with external beam ra...

    Authors: Miikka Lehtonen, Lauri Heiskanen, Petri Reinikainen and Pirkko-Liisa Kellokumpu-Lehtinen
    Citation: BMC Cancer 2020 20:324
    Content type: Research article Published on:

  39. Febrile neutropenia (FN) occurs following myelosuppressive chemotherapy and is associated with morbidity, mortality, costs, and chemotherapy reductions and delays. Granulocyte colony-stimulating factors (G-CSF...

    Authors: Katy L Cooper, Jason Madan, Sophie Whyte, Matt D Stevenson and Ron L Akehurst
    Citation: BMC Cancer 2011 11:404
    Content type: Research article Published on:

  40. Squamous cell carcinoma of the head and neck (SCCHN) remains a prevalent and devastating disease. Recently, there has been an increase in SCCHN cases that are associated with high-risk human papillomavirus (HP...

    Authors: Bhavana V. Chapman, Abigail I. Wald, Parvez Akhtar, Ana C. Munko, Jingjing Xu, Sandra P. Gibson, Jennifer R. Grandis, Robert L. Ferris and Saleem A. Khan
    Citation: BMC Cancer 2015 15:861
    Content type: Research article Published on:

  41. miR-21, miR-26b, miR-221/222 and miR-126 play crucial roles in cervical cancer development. Studies have shown that polymorphisms in miRNA genes can affect miRNA expression, which might be associated with cancer ...

    Authors: Jia Yang, Zhiling Yan, Yingying Wang, Jinmei Xu, Rui Li, Chuanyin Li, Shuyuan Liu, Li Shi and Yufeng Yao
    Citation: BMC Cancer 2021 21:997
    Content type: Research Published on:

  42. Our previous proteomic analysis revealed that mitogen-activated protein kinase activator with WD40 repeats (MAWD) and MAWD-binding protein (MAWBP) were downregulated in gastric cancer (GC) tissues. These prote...

    Authors: Dongmei Li, Jun Zhang, Yu Xi, Lei Zhang, Wenmei Li, Jiantao Cui, Rui Xing, Yuanmin Pan, Zemin Pan, Feng Li and Youyong Lu
    Citation: BMC Cancer 2015 15:637
    Content type: Research article Published on:

  43. To evaluate the use of intraoperative radiation therapy (IORT) in the multimodality treatment of patients with isolated local recurrences of pancreatic cancer.

    Authors: Falk Roeder, Carmen Timke, Matthias Uhl, Gregor Habl, Frank W Hensley, Markus W Buechler, Robert Krempien, Peter E Huber, Juergen Debus and Jens Werner
    Citation: BMC Cancer 2012 12:295
    Content type: Research article Published on:

  44. Tracheobronchial adenoid cystic carcinoma (TACC) is a rare tumour. About one-third of patients miss their chance of surgery or complete resection as it is mostly detected in the advanced stage; hence, photon r...

    Authors: Jian Chen, Jingfang Mao, Ningyi Ma, Kai-Liang Wu, Jiade Lu and Guo-Liang Jiang
    Citation: BMC Cancer 2021 21:734
    Content type: Research Published on:

  45. Treatment with programmed cell death receptor (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors is a promising strategy to lift tumour-induced immune response suppression. However, the current syste...

    Authors: J. Rotman, C. H. Mom, E. S. Jordanova, T. D. de Gruijl and G. G. Kenter
    Citation: BMC Cancer 2018 18:888
    Content type: Study protocol Published on:

  46. Angiogenesis is important in the growth and metastasis of various kinds of solid tumors, including gastric cancers. The angiogenic process is triggered by several key growth factors, including vascular endothe...

    Authors: Shioto Suzuki, Yoh Dobashi, Yayoi Hatakeyama, Ryosuke Tajiri, Takashi Fujimura, Carl H Heldin and Akishi Ooi
    Citation: BMC Cancer 2010 10:659
    Content type: Research article Published on:

  47. Almost one-third of patients with diffuse large B-cell lymphoma (DLBCL) cannot be cured with initial therapy and will eventually succumb to the disease. Further elaboration of prognostic markers of DLBCL will ...

    Authors: Tianjiao Tang, Jing Wang, Lidan Zhang, Ying Cheng, Laura Saleh, Yanni Gu and Hongbin Zhang
    Citation: BMC Cancer 2021 21:603
    Content type: Research article Published on:

  48. Genetic profiling of cancers for variations in copy number, structure or expression of certain genes has improved diagnosis, risk-stratification and therapeutic decision-making. However the tumor-restricted na...

    Authors: Jordan Mandel, Huabo Wang, Daniel P. Normolle, Wei Chen, Qi Yan, Peter C. Lucas, Panayiotis V. Benos and Edward V. Prochownik
    Citation: BMC Cancer 2019 19:686
    Content type: Research article Published on:

  49. To analyse the prognostic significance of preoperative C-reactive protein (CRP) serum level in patients with upper urinary tract urothelial carcinoma (UUT-UC).

    Authors: Barbara Stein, Andres Jan Schrader, Gerd Wegener, Christoph Seidel, Markus A Kuczyk and Sandra Steffens
    Citation: BMC Cancer 2013 13:101
    Content type: Research article Published on:

  50. Hypopharyngeal cancer is a relatively rare malignancy with poor prognosis. Current chemotherapeutic algorithm is still far from personalized medicine, and the identification of the truly active therapeutic bio...

    Authors: Yumiko Kawata-Shimamura, Hidetaka Eguchi, Reika Kawabata-Iwakawa, Mitsuhiko Nakahira, Yasushi Okazaki, Tetsuya Yoda, Reidar Grénman, Masashi Sugasawa and Masahiko Nishiyama
    Citation: BMC Cancer 2022 22:779
    Content type: Research Published on:

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