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3909 result(s) for 'lung cancer prognosis stage 4' within BMC Cancer

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  1. A malignancy of the liver, hepatocellular carcinoma (HCC) is among the most common and second-leading causes of cancer-related deaths worldwide. A reliable prognosis model for guidance in choosing HCC therapie...

    Authors: Chunting Zeng, Linmeng Zhang, Chanhua Luo, Chen Yang, Xiaowen Huang, Linfeng Fan, Jiarong Li, Fengsheng Chen and Zelong Luo
    Citation: BMC Cancer 2022 22:613
    Content type: Research article Published on:

  2. Uterine sarcoma is an uncommon aggressive malignancy. Optimal management and prognostic factors have yet to be well recognized due to their rarity and various histological subtypes. This study aims to investig...

    Authors: Saqib Raza Khan, Salman Muhammad Soomar, Tamana Asghari, Arsalan Ahmed and Munira Shabbir Moosajee
    Citation: BMC Cancer 2023 23:510
    Content type: Research Published on:

  3. Metastasis is a leading cause of breast cancer mortality. The induction of epithelial-to-mesenchymal transition (EMT) and complex oncogenic signaling is a vital step in the evolution of highly metastatic and t...

    Authors: Jia-Hong Chen, Wen-Chien Huang, Oluwaseun Adebayo Bamodu, Peter Mu-Hsin Chang, Tsu-Yi Chao and Tse-Hung Huang
    Citation: BMC Cancer 2019 19:634
    Content type: Research article Published on:

  4. Prostate cancer screening among the general population is highly debatable. Nevertheless, screening among high-risk groups is appealing. Prior data suggests that men carrying mutations in the BRCA1& 2 genes ma...

    Authors: David Margel, Ofer Benjaminov, Rachel Ozalvo, Liat Shavit Grievink, Inbal Kedar, Rinat Yerushalmi, Irit Ben-Aharon, Victoria Neiman, Ofer Yossepowitch, Daniel Kedar, Zohar Levy, Mordechai Shohat, Baruch Brenner, Jack Baniel and Eli Rosenbaum
    Citation: BMC Cancer 2014 14:528
    Content type: Study protocol Published on:

  5. In this retrospective study we evaluated the respective correlations and clinical relevance of FOLR1 mRNA expression, FOLR1 promoter specific methylation and global DNA hypomethylation in type I and type II ov...

    Authors: Sara Notaro, Daniel Reimer, Heidi Fiegl, Gabriel Schmid, Annamarie Wiedemair, Julia Rössler, Christian Marth and Alain Gustave Zeimet
    Citation: BMC Cancer 2016 16:589
    Content type: Research article Published on:

  6. Indoleamine 2, 3-dioxygenase-1 (IDO1) is a promising target for immunotherapy in bladder cancer (BC). IDO1 breaks-down tryptophan to generate kynurenine derivatives, which may activate the aryl hydrocarbon rec...

    Authors: Luiz Henrique Gomes Matheus, Stephanie Vanin Dalmazzo, Rodrigo Barbosa Oliveira Brito, Lucas Alves Pereira, Robson José de Almeida, Cleber Pinto Camacho and Humberto Dellê
    Citation: BMC Cancer 2020 20:869
    Content type: Research article Published on:

  7. The S6 Kinase (S6K) proteins are some of the main downstream effectors of the mammalian Target Of Rapamycin (mTOR) and act as key regulators of protein synthesis and cell growth. S6K is overexpressed in a vari...

    Authors: Camila L. Amaral, Lidia B. Freitas, Rodrigo E. Tamura, Mariana R. Tavares, Isadora C. B. Pavan, Marcio C. Bajgelman and Fernando M. Simabuco
    Citation: BMC Cancer 2016 16:602
    Content type: Research article Published on:

  8. Nasopharyngeal carcinoma (NPC) is a highly metastatic epithelial malignancy showing high prevalence in Southeast Asia and North Africa. The BCL2-associated X (BAX) gene encodes the most important pro-apoptotic me...

    Authors: Christos K Kontos, Ali Fendri, Abdelmajid Khabir, Raja Mokdad-Gargouri and Andreas Scorilas
    Citation: BMC Cancer 2013 13:293
    Content type: Research article Published on:

  9. TAB182 participates in DNA damage repair and radio-/chemosensitivity regulation in various tumors, but its role in tumorigenesis and therapeutic resistance in breast cancer remains unclear. In the current pape...

    Authors: Huan He, Shaozheng Wang, Wen Zhang, Shanshan Gao, Hua Guan and Pingkun Zhou
    Citation: BMC Cancer 2023 23:1101
    Content type: Research Published on:

  11. Due to the lack of effective therapies and poor prognosis in TNBC (triple-negative breast cancer) patients, there is a strong need to develop effective novel targeted therapies for this subtype of breast cance...

    Authors: Nuramalina H. Mumin, Neele Drobnitzky, Agata Patel, Luiza Madia Lourenco, Fiona F. Cahill, Yanyan Jiang, Anthony Kong and Anderson J. Ryan
    Citation: BMC Cancer 2019 19:102
    Content type: Research article Published on:

  12. NR4A orphan nuclear receptors are involved in multiple biological processes which are important in tumorigenesis such as cell proliferation, apoptosis, differentiation, and glucose utilization. The significanc...

    Authors: Shawn Llopis, Brittany Singleton, Tamika Duplessis, Latonya Carrier, Brian Rowan and Christopher Williams
    Citation: BMC Cancer 2013 13:139
    Content type: Research article Published on:

  13. The impact and consequences of cancer on the patients and their family caregivers (FCs) are closely intertwined. Caregivers’ burdens can be increased due to the patients’ unmet needs and unresolved problems. A...

    Authors: Gek Phin Chua, Grace Su Yin Pang, Alethlea Chung Pheng Yee, Patricia Soek Hui Neo, Siqin Zhou, Cindy Lim, Yin Yee Wong, Debra Limin Qu, Fang Ting Pan and Grace Meijuan Yang
    Citation: BMC Cancer 2020 20:768
    Content type: Research article Published on:

  14. Members of the urokinase-type plasminogen activator (uPA) system are up-regulated in various solid malignant tumors. High antigen levels of uPA, its inhibitor PAI-1 and its receptor uPAR have recently been sho...

    Authors: Matthias Kotzsch, Viktor Magdolen, Thomas Greither, Matthias Kappler, Matthias Bache, Christine Lautenschläger, Susanne Füssel, Alexander W Eckert, Thomas Luther, Gustavo Baretton, Peter Würl and Helge Taubert
    Citation: BMC Cancer 2011 11:273
    Content type: Research article Published on:

  16. Transarterial chemoembolization (TACE) therapy is an effective locoregional treatment in hepatocellular cancer (HCC) patients. For early modification of therapy, markers predicting therapy response are urgentl...

    Authors: Nikolaus Kohles, Dorothea Nagel, Dietrich Jüngst, Jürgen Durner, Petra Stieber and Stefan Holdenrieder
    Citation: BMC Cancer 2011 11:202
    Content type: Research article Published on:

  17. Preoperative prediction of microsatellite instability (MSI) status in colorectal cancer (CRC) patients is of great significance for clinicians to perform further treatment strategies and prognostic evaluation....

    Authors: Mingliang Ying, Jiangfeng Pan, Guanghong Lu, Shaobin Zhou, Jianfei Fu, Qinghua Wang, Lixia Wang, Bin Hu, Yuguo Wei and Junkang Shen
    Citation: BMC Cancer 2022 22:524
    Content type: Research Published on:

  18. ERBB3 binding protein 1 (EBP1) gene transfer into human salivary adenoid cystic carcinoma cells has been shown to significantly inhibit cell proliferation and reduce tumor metastasis in mouse models. In the curre...

    Authors: Jian Sun, Yixi Luo, Zhen Tian, Liang Gu, Shu Chi Xia and Youcheng Yu
    Citation: BMC Cancer 2012 12:499
    Content type: Research article Published on:

  19. Retrospective studies show improved outcomes in colorectal cancer patients if taking statins, including overall survival, pathological response of rectal cancer to preoperative chemoradiotherapy (pCRT), and re...

    Authors: Michael B. Jameson, Kirsten Gormly, David Espinoza, Wendy Hague, Gholamreza Asghari, Grahame Mark Jeffery, Timothy Jay Price, Christos Stelios Karapetis, Michael Arendse, James Armstrong, John Childs, Frank A. Frizelle, Sam Ngan, Andrew Stevenson, Martinus Oostendorp and Stephen P. Ackland
    Citation: BMC Cancer 2019 19:1229
    Content type: Study protocol Published on:

  20. Although the effectiveness of radiotherapy with concurrent administration of several anti-tumor drugs for postoperative recurrent esophageal cancer has been demonstrated, the results are not satisfactory. The ...

    Authors: Keiichi Jingu, Kenji Nemoto, Haruo Matsushita, Chiaki Takahashi, Yoshihiro Ogawa, Toshiyuki Sugawara, Eiko Nakata, Yoshihiro Takai and Shogo Yamada
    Citation: BMC Cancer 2006 6:50
    Content type: Research article Published on:

  21. The proinflammatory cytokine interleukin-1 (IL-1) is known to play an important role in the carcinogenesis of breast cancer. Although IL-1 gene polymorphisms were reported to be associated with increased risk ...

    Authors: Christoph Grimm, Eva Kantelhardt, Georg Heinze, Stephan Polterauer, Robert Zeillinger, Heinz Kölbl, Alexander Reinthaller and Lukas Hefler
    Citation: BMC Cancer 2009 9:78
    Content type: Research article Published on:

  22. The “EMERGE” study, aimed to capture real-life management patterns and outcomes in metastatic breast cancer (MBC) in Greece, also accounting for hormone (HR) and human epidermal growth factor receptor 2 (HER2)...

    Authors: Athanasios Kotsakis, Alexandros Ardavanis, Georgios Koumakis, Epameinondas Samantas, Amanta Psyrri and Christos Papadimitriou
    Citation: BMC Cancer 2019 19:88
    Content type: Research article Published on:

  23. Competing risk method has not been used in a large-scale prospective study to investigate whether increased levels of high-sensitivity C-reactive protein (hs-CRP) elevate the risk of primary liver cancer (PLC)...

    Authors: Sarah Tan Siyin, Tong Liu, Wenqiang Li, Nan Yao, Guoshuai Xu, Jun Qu and Yajun Chen
    Citation: BMC Cancer 2020 20:1168
    Content type: Research article Published on:

  24. Trials investigating neoadjuvant treatment with immune checkpoint inhibitors (ICI) in patients with melanoma have shown high clinical and pathologic response rates. Treatment with talimogene laherparepvec (T-V...

    Authors: Maartje W. Rohaan, Emma H. A. Stahlie, Viola Franke, Lisanne P. Zijlker, Sofie Wilgenhof, Vincent van der Noort, Alexander C. J. van Akkooi and John B. A. G. Haanen
    Citation: BMC Cancer 2022 22:851
    Content type: Study protocol Published on:

  25. It has been suggested that the B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays an oncogenic role in several types of human cancer, but the status of Bmi-1 amplification and expression i...

    Authors: Guo-Fen Yang, Wei-Peng He, Mu-Yan Cai, Li-Ru He, Jun-Hang Luo, Hai-Xia Deng, Xin-Yuan Guan, Mu-Sheng Zeng, Yi-Xin Zeng and Dan Xie
    Citation: BMC Cancer 2010 10:133
    Content type: Research article Published on:

  26. Prostate cancer is characterized by heterogeneity in the clinical course that often does not correlate with morphologic features of the tumor. Metastasis reflects the most adverse outcome of prostate cancer, a...

    Authors: Uma R Chandran, Changqing Ma, Rajiv Dhir, Michelle Bisceglia, Maureen Lyons-Weiler, Wenjing Liang, George Michalopoulos, Michael Becich and Federico A Monzon
    Citation: BMC Cancer 2007 7:64
    Content type: Research article Published on:

  27. Circular RNAs (circRNAs) have emerged as a novel category of non-coding RNA, which exhibit a pivotal effect on regulating gene expression and biological functions, yet how circRNAs function in osteosarcoma (OS...

    Authors: Houkun Li, Limin He, Yuan Tuo, Yansheng Huang and Bing Qian
    Citation: BMC Cancer 2020 20:1026
    Content type: Research article Published on:

  28. FAS/FASL promoter variants are considered in altering transcriptional activity of those genes and consequently alter regulation of cell death. However, no studies have investigated whe...

    Authors: Yan Sun, Wenbin Yu, Erich M. Sturgis, Wei Peng, Dapeng Lei, Qingyi Wei, Xicheng Song and Guojun Li
    Citation: BMC Cancer 2016 16:70
    Content type: Research article Published on:

  29. Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide. The only drug currently approved for clinical use in the treatment of advanced HCC is sorafenib. However, many patients w...

    Authors: Hanhee Jo, Yusun Park, Taehun Kim, Jisu Kim, Jong Sook Lee, Seon Yoo Kim, Jee-in Chung, Hae yong Ko, Jae-Chul Pyun, Kyung Sik Kim, Misu Lee and Mijin Yun
    Citation: BMC Cancer 2020 20:332
    Content type: Research article Published on:

  30. Cancer survivors are at risk of developing a second primary cancer (SPC) later in life because of persisting effects of genetic and behavioural risk factors, the long-term sequelae of chemotherapy, radiotherap...

    Authors: Oliver Preyer, Nicole Concin, Andreas Obermair, Hans Concin, Hanno Ulmer and Willi Oberaigner
    Citation: BMC Cancer 2017 17:699
    Content type: Research article Published on:

  33. Leptomeningeal metastasis (LM) is a predominantly late stage, devastating complication of a variety of malignant solid tumors. Diagnosis relies predominantly on neurological, radiographic, and cerebrospinal fl...

    Authors: Ann-Kathrin Stoppek, Sied Kebir, Andreas Junker, Kathy Keyvani, Stefan Zülow, Lazaros Lazaridis, Teresa Schmidt, Daniela Pierscianek, Martin Stuschke, Ulrich Sure, Christoph Kleinschnitz, Björn Scheffler, Lisa Zimmer and Martin Glas
    Citation: BMC Cancer 2019 19:995
    Content type: Case report Published on:

  34. The development of breast cancer is multifactorial. Hormonal, environmental factors and genetic predisposition, among others, could interact in the presentation of breast carcinoma. Human leukocyte antigen (HL...

    Authors: David Cantú de León, Delia Pérez-Montiel, Verónica Villavicencio, Alejandro García Carranca, Alejandro Mohar Betancourt, Victor Acuña-Alonzo, Alberto López-Tello, Gilberto Vargas-Alarcón, Rodrigo Barquera, Neng Yu, Edmond J Yunis and Julio Granados
    Citation: BMC Cancer 2009 9:48
    Content type: Research article Published on:

  35. Patients with recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) receiving platinum-based chemotherapy as their first-line treatment have a dismal prognosis, with a median overall ...

    Authors: Jean-Pascal H Machiels, Lisa F Licitra, Robert I Haddad, Makoto Tahara and Ezra EW Cohen
    Citation: BMC Cancer 2014 14:473
    Content type: Study protocol Published on:

  36. The role of circulating tumor cells (CTCs) in prognosis prediction has been actively studied in hepatocellular carcinoma (HCC) patients. However, their efficiency in accurately predicting early progression rec...

    Authors: Zhan Lu, Hanghang Ni, Xihua Yang, Lihao Tan, Haixiao Zhuang, Yunning Mo, Xingyu Wei, Lunan Qi and Bangde Xiang
    Citation: BMC Cancer 2023 23:1150
    Content type: Research Published on:

  37. The gasdermin E gene (GSDME, also known as DFNA5) is mutated in familial aging-related hearing loss. Recent studies have also revealed that the expression of DFNA5 is suppressed in many cancer types; however, lit...

    Authors: Zhiguo Liu, Hongyan Liu, Qian Dong, Hongyu Li, Bin Zhang, Yufeng Liu, Limei Zhong and Haikuo Tang
    Citation: BMC Cancer 2021 21:951
    Content type: Research Published on:

  38. Vitamin and mineral supplement use after a breast cancer diagnosis is common and controversial. Dosages used and the timing of initiation and/or discontinuation of supplements have not been clearly described.

    Authors: Heather Greenlee, Marilyn L Kwan, Isaac J Ergas, Garrett Strizich, Janise M Roh, Allegra T Wilson, Marion Lee, Karen J Sherman, Christine B Ambrosone, Dawn L Hershman, Alfred I Neugut and Lawrence H Kushi
    Citation: BMC Cancer 2014 14:382
    Content type: Research article Published on:

  40. High grade serous ovarian carcinoma (HGSOC) is the most common subtype of epithelial ovarian cancers (EOC) with poor prognosis. In most cases EOC is widely disseminated at the time of diagnosis. Despite the op...

    Authors: H. Sallinen, S. Janhonen, P. Pölönen, H. Niskanen, O. H. Liu, A. Kivelä, J. M. Hartikainen, M. Anttila, M. Heinäniemi, S. Ylä-Herttuala and M. U. Kaikkonen
    Citation: BMC Cancer 2019 19:1121
    Content type: Research article Published on:

  41. Fibronectin (FN) is a high-molecular-weight glycoprotein component of the extracellular matrix involved in cell adhesion, migration, metastasis, proliferation and differentiation, as well as embryogenesis, wou...

    Authors: Jiefei Xiao, Weilin Yang, Bo Xu, Haoshuai Zhu, Jianyong Zou, Chunhua Su, Jian Rong, Tao Wang and Zhenguang Chen
    Citation: BMC Cancer 2018 18:976
    Content type: Research article Published on:

  42. Small extracellular vesicles (small-EVs) are membranous vesicles that contain unique information regarding the condition of cells and contribute to the recruitment and reprogramming of components associated wi...

    Authors: Chan-Hyeong Lee, Eun-Ju Im, Pyong-Gon Moon and Moon-Chang Baek
    Citation: BMC Cancer 2018 18:1058
    Content type: Research article Published on:

  43. Epithelial to mesenchymal transition (EMT) is the process by which stationary epithelial cells transdifferentiate to mesenchymal cells with increased motility. EMT is integral in early stages of development an...

    Authors: Princy Parsana, Sarah R. Amend, James Hernandez, Kenneth J. Pienta and Alexis Battle
    Citation: BMC Cancer 2017 17:447
    Content type: Research article Published on:

  44. Osteosarcoma often develops micrometastases in the lung prior to diagnosis, causing a fatal outcome. Therefore, the prevention of pulmonary metastases is critical for the improvement of the prognosis of patien...

    Authors: Junichi Aizawa, Kenshi Sakayama, Setsuya Kamei, Teruki Kidani, Haruyasu Yamamoto, Yoshiaki Norimatsu and Hiroshi Masuno
    Citation: BMC Cancer 2010 10:51
    Content type: Research article Published on:

  45. This study aimed to evaluate the behavior of non-muscle-invasive bladder cancer (NMIBC) in patients submitted to transurethral bladder resection (TURB) comparing subjects in chronic therapy with aspirin, stati...

    Authors: Antonio Luigi Pastore, Giovanni Palleschi, Andrea Fuschi, Luigi Silvestri, Yazan Al Salhi, Elisabetta Costantini, Alessandro Zucchi, Vincenzo Petrozza, Cosimo de Nunzio and Antonio Carbone
    Citation: BMC Cancer 2015 15:120
    Content type: Research article Published on:

  47. The pathogenesis of multiple myeloma involves complex genetic and epigenetic events. This study aimed to investigate the role and clinical relevance of the long non-coding RNA (lncRNA), metastasis-associated l...

    Authors: Shih-Feng Cho, Yuli Christine Chang, Chao-Sung Chang, Sheng-Fung Lin, Yi-Chang Liu, Hui-Hua Hsiao, Jan-Gowth Chang and Ta-Chih Liu
    Citation: BMC Cancer 2014 14:809
    Content type: Research article Published on:

  48. Gastric cancer (GC) lacks serum biomarkers with clinical diagnostic value. Multi-omics analysis is an important approach to discovering cancer biomarkers. This study aimed to identify and validate serum biomar...

    Authors: Shao-Song Liu, Qin-Si Wan, Cong Lv, Jin-Ke Wang, Song Jiang, Dan Cai, Mao-Sheng Liu, Ting Wang and Kun-He Zhang
    Citation: BMC Cancer 2024 24:465
    Content type: Research Published on:

  49. High circulating tumor cell (CTC) counts are associated with poor prognosis in advanced prostate cancer, and recently CTC number was suggested to be a surrogate for survival in metastatic castrate-resistant pr...

    Authors: C. R. Lindsay, S. Le Moulec, F. Billiot, Y. Loriot, M. Ngo-Camus, P. Vielh, K. Fizazi, C. Massard and F. Farace
    Citation: BMC Cancer 2016 16:168
    Content type: Research article Published on:

  50. Atypical tumor response patterns during immune checkpoint inhibitor therapy pose a challenge to clinicians and investigators in immuno-oncology practice. This study evaluated tumor burden dynamics to identify ...

    Authors: Peiyi Xie, Hong Zheng, Haiyang Chen, Kaikai Wei, Ximin Pan, Qinmei Xu, Yongchen Wang, Changguan Tang, Olivier Gevaert and Xiaochun Meng
    Citation: BMC Cancer 2021 21:1246
    Content type: Research Published on:

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