Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87–108.
Article
PubMed
Google Scholar
DeSantis CE, Lin CC, Mariotto AB, Siegel RL, Stein KD, Kramer JL, et al. Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin. 2014;64(4):252–71.
Article
PubMed
Google Scholar
Tavares MR, Pavan ICB, Amaral CL, Meneguello L, Luchessi AD, Simabuco FM. The S6K protein family in health and disease. Life Sci. 2015;131:1–10.
Article
CAS
PubMed
Google Scholar
Magnuson B, Ekim B, Fingar DC. Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks. Biochem J. 2012;441(1):1–21.
Article
CAS
PubMed
Google Scholar
Karni R, De Stanchina E, Lowe SW, Sinha R, Mu D, Krainer AR. The gene encoding the splicing factor SF2/ASF is a proto-oncogene. Nat Struct Mol Biol. 2007;14(3):185–93.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kremer CL, Klein RR, Mendelson J, Browne W, Samadzedeh LK, Vanpatten K, et al. Expression of mTOR signaling pathway markers in prostate cancer progression. Prostate. 2006;66(11):1203–12.
Article
CAS
PubMed
Google Scholar
Menon S, Manning BD. Common corruption of the mTOR signaling network in human tumors. Oncogene. 2008;27(0 2):S43–51.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yoshida S, Matsumoto K, Arao T, Taniguchi H, Goto I, Hanafusa T, et al. Gene Amplification of Ribosomal Protein S6 Kinase-1 and–2 in Gastric Cancer. Anticancer Res. 2013;33(2):469–75.
CAS
PubMed
Google Scholar
Savinska LO, Lyzogubov VV, Usenko VS, Ovcharenko GV, Gorbenko ON, Rodnin MV, et al. Immunohistochemical analysis of S6K1 and S6K2 expression in human breast tumors. Eksp Onkol. 2004;26(1):24–30.
CAS
PubMed
Google Scholar
Kinkade CW, Castillo-Martin M, Puzio-Kuter A, Yan J, Foster TH, Gao H, et al. Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model. J Clin Invest. 2008;118(9):3051–64.
CAS
PubMed
PubMed Central
Google Scholar
Pardo OE, Seckl MJ. S6K2: The Neglected S6 Kinase Family Member. Frontiers in Oncology. 2013;3:191.
Article
PubMed
PubMed Central
Google Scholar
Karlsson E, Magić I, Bostner J, Dyrager C, Lysholm F, Hallbeck A-L, et al. Revealing Different Roles of the mTOR-Targets S6K1 and S6K2 in Breast Cancer by Expression Profiling and Structural Analysis. PLoS One. 2015;10(12):e0145013.
Article
PubMed
PubMed Central
Google Scholar
Inoue T, Yoshida T, Shimizu Y, Kobayashi T, Yamasaki T, Toda Y, et al. Requirement of Androgen-Dependent Activation of Protein Kinase Cζ for Androgen-Dependent Cell Proliferation in LNCaP Cells and Its Roles in Transition to Androgen-Independent Cells. Mol Endocrinol. 2006;20(12):3053–69.
Article
CAS
PubMed
Google Scholar
Kobayashi T, Shimizu Y, Terada N, Yamasaki T, Nakamura E, Toda Y, et al. Regulation of androgen receptor transactivity and mTOR–S6 kinase pathway by Rheb in prostate cancer cell proliferation. Prostate. 2010;70(8):866–74.
CAS
PubMed
Google Scholar
Park J-Y, Park J-W, Suh S-I, Baek W-K. d-Glucosamine down-regulates HIF-1α through inhibition of protein translation in DU145 prostate cancer cells. Biochem Biophys Res Commun. 2009;382(1):96–101.
Article
CAS
PubMed
Google Scholar
Sahin F, Kannangai R, Adegbola O, Wang J, Su G, Torbenson M. mTOR and P70 S6 Kinase Expression in Primary Liver Neoplasms. Clin Cancer Res. 2004;10(24):8421–5.
Article
CAS
PubMed
Google Scholar
Ip CKM, Wong AST. Exploiting p70 S6 kinase as a target for ovarian cancer. Expert Opin Ther Targets. 2012;16(6):619–30.
Article
CAS
PubMed
Google Scholar
Baba HA, Wohlschlaeger J, Cicinnati VR, Hilgard P, Lang H, Sotiropoulos GC, et al. Phosphorylation of p70S6 kinase predicts overall survival in patients with clear margin-resected hepatocellular carcinoma. Liver Int. 2009;29(3):399–405.
Article
CAS
PubMed
Google Scholar
Nozawa H, Watanabe T, Nagawa H. Phosphorylation of ribosomal p70 S6 kinase and rapamycin sensitivity in human colorectal cancer. Cancer Lett. 2007;251(1):105–13.
Article
CAS
PubMed
Google Scholar
Carnevalli LS, Masuda K, Frigerio F, Le Bacquer O, Um SH, Gandin V, et al. S6K1 Plays a Critical Role in Early Adipocyte Differentiation. Dev Cell. 2010;18(5):763–74.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bajgelman MC, Costanzi-Strauss E, Strauss BE. Exploration of critical parameters for transient retrovirus production. J Biotechnol. 2003;103(2):97–106.
Article
CAS
PubMed
Google Scholar
Strauss BE, Patrício JR, De Carvalho ACV, Bajgelman MC. A lentiviral vector with expression controlled by E2F-1: A potential tool for the study and treatment of proliferative diseases. Biochem Biophys Res Commun. 2006;348(4):1411–8.
Article
CAS
PubMed
Google Scholar
Liang C-C, Park AY, Guan J-L. In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protocols. 2007;2(2):329–33.
Article
CAS
PubMed
Google Scholar
Uzoh CC, Holly JMP, Biernacka KM, Persad RA, Bahl A, Gillatt D, et al. Insulin-like growth factor-binding protein-2 promotes prostate cancer cell growth via IGF-dependent or -independent mechanisms and reduces the efficacy of docetaxel. Br J Cancer. 2011;104(10):1587–93.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pearce Laura R, Alton Gordon R, Richter Daniel T, Kath John C, Lingardo L, Chapman J, et al. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem J. 2010;431(2):245–55.
Article
CAS
PubMed
Google Scholar
Pende M, Um SH, Mieulet V, Sticker M, Goss VL, Mestan J, et al. S6K1 (−/−)/S6K2 (−/−) Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway. Mol Cell Biol. 2004;24(8):3112–24.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shima H, Pende M, Chen Y, Fumagalli S, Thomas G, Kozma SC. Disruption of the p70 (s6k)/p85 (s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J. 1998;17(22):6649–59.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hwang C. Overcoming docetaxel resistance in prostate cancer: a perspective review. Therapeutic Advances in Medical Oncology. 2012;4(6):329–40.
Article
CAS
PubMed
PubMed Central
Google Scholar
Man Ip CK, Yung S, Chan T-M, Tsao S-W, Tsai Wong AS. p70 S6 kinase drives ovarian cancer metastasis through multicellular spheroid-peritoneum interaction and P-cadherin/β1 integrin signaling activation. Oncotarget. 2014;5(19):9133–49.
Article
PubMed Central
Google Scholar
Karlsson E, Pérez-Tenorio G, Amin R, Bostner J, Skoog L, Fornander T, et al. The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer: a retrospective study including patients from the randomised Stockholm tamoxifen trials. Breast Cancer Res. 2013;15(5):R96.
Article
PubMed
PubMed Central
Google Scholar
Du Y-F, Long Q-Z, Shi Y, Liu X-G, Li X-D, Zeng J, et al. Downregulation of mTOR by lentivirus inhibits prostate cancer cell growth. Int J Clin Exp Pathol. 2014;7(3):923–31.
PubMed
PubMed Central
Google Scholar
Berven LA, Crouch MF. Cellular function of p70S6K: A role in regulating cell motility. Immunol Cell Biol. 2000;78(4):447–51.
Article
CAS
PubMed
Google Scholar
Zhou H, Huang S. Role of mTOR Signaling in Tumor Cell Motility, Invasion and Metastasis. Curr Protein Pept Sci. 2011;12(1):30–42.
Article
PubMed
PubMed Central
Google Scholar
Ip CKM, Cheung ANY, Ngan HYS, Wong AST. p70 S6 kinase in the control of actin cytoskeleton dynamics and directed migration of ovarian cancer cells. Oncogene. 2011;30(21):2420–32.
Article
CAS
PubMed
Google Scholar
Berven LA, Willard FS, Crouch MF. Role of the p70S6K pathway in regulating the actin cytoskeleton and cell migration. Exp Cell Res. 2004;296(2):183–95.
Article
CAS
PubMed
Google Scholar
Liwak U, Thakor N, Jordan LE, Roy R, Lewis SM, Pardo OE, et al. Tumor Suppressor PDCD4 Represses Internal Ribosome Entry Site-Mediated Translation of Antiapoptotic Proteins and Is Regulated by S6 Kinase 2. Mol Cell Biol. 2012;32(10):1818–29.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pardo OE, Wellbrock C, Khanzada UK, Aubert M, Arozarena I, Davidson S, et al. FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCɛ, B-Raf and S6K2. EMBO J. 2006;25(13):3078–88.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jiang B-H, Liu L-Z. Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment. Drug Resist Updat. 2008;11(3):63–76.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cai Y, Tan X, Liu J, Shen Y, Wu D, Ren M, et al. Inhibition of PI3K/Akt/mTOR signaling pathway enhances the sensitivity of the SKOV3/DDP ovarian cancer cell line to cisplatin in vitro. Chin J Cancer Res. 2014;26(5):564–72.
CAS
PubMed
PubMed Central
Google Scholar
Sui X, Chen R, Wang Z, Huang Z, Kong N, Zhang M, et al. Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment. Cell Death Dis. 2013;4:e838.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang Z, Huang Y, Zhang J. Molecularly targeting the PI3K-Akt-mTOR pathway can sensitize cancer cells to radiotherapy and chemotherapy. Cell Mol Biol Lett. 2014;19(2):233.
Article
CAS
PubMed
Google Scholar
Yardley DA. Combining mTOR Inhibitors with Chemotherapy and Other Targeted Therapies in Advanced Breast Cancer: Rationale, Clinical Experience, and Future Directions. Breast Cancer. 2013;7:7–22.
CAS
PubMed
PubMed Central
Google Scholar
Weiler M, Blaes J, Pusch S, Sahm F, Czabanka M, Luger S, et al. mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy. Proc Natl Acad Sci U S A. 2014;111(1):409–14.
Article
CAS
PubMed
Google Scholar
Niu H, Wang J, Li H, He P. Rapamycin potentiates cytotoxicity by docetaxel possibly through downregulation of Survivin in lung cancer cells. J Exp Clin Cancer Res. 2011;30(1):28.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yasumizu Y, Miyajima A, Kosaka T, Miyazaki Y, Kikuchi E, Oya M. Dual PI3K/mTOR Inhibitor NVP-BEZ235 Sensitizes Docetaxel in Castration Resistant Prostate Cancer. J Urol. 2014;191(1):227–34.
Article
CAS
PubMed
Google Scholar
Carracedo A, Pandolfi PP. The PTEN-PI3K pathway: of feedbacks and cross-talks. Oncogene. 2008;27(41):5527–41.
Article
CAS
PubMed
Google Scholar
Grasso S, Tristante E, Saceda M, Carbonell P, Mayor-López L, Carballo-Santana M, et al. Resistance to Selumetinib (AZD6244) in Colorectal Cancer Cell Lines is Mediated by p70S6K and RPS6 Activation. Neoplasia (New York, NY). 2014;16(10):845–60.
Article
Google Scholar
Khotskaya YB, Goverdhan A, Shen J, Ponz-Sarvise M, Chang S-S, Hsu M-C, et al. S6K1 promotes invasiveness of breast cancer cells in a model of metastasis of triple-negative breast cancer. Am J Transl Res. 2014;6(4):361–76.
PubMed
PubMed Central
Google Scholar
Qiu Z-X, Sun R-F, Mo X-M, Li W-M. The p70S6K Specific Inhibitor PF-4708671 Impedes Non-Small Cell Lung Cancer Growth. PLoS One. 2016;11(1):e0147185.
Article
PubMed
PubMed Central
Google Scholar