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  1. Alternative polyadenylation (APA) is emerging as a crucial regulatory mechanism in bladder cancer (BC), while it remains elusive whether APA influences the tumor immune microenvironment (TIME) in BC. We identi...

    Authors: Ming Xiong, Wencheng Li, Longwang Wang, Liang Chen, Zhaohui Chen, Chengcheng Wei, Futian Zhang, Jiawei Chen, Gallina Kazobinka, Jun Zhao and Teng Hou
    Citation: BMC Cancer 2022 22:1026
    Content type: Research Published on:

  2. Telomere dysfunction results in aneuploidy, and ongoing chromosomal abnormalities. The three-dimensional (3D) nuclear organization of telomeres allows for a distinction between normal and tumor cells. On the o...

    Authors: Fábio Morato de Oliveira, Valderez Ravaglio Jamur, Lismeri Wuicik Merfort, Aline Rangel Pozzo and Sabine Mai
    Citation: BMC Cancer 2022 22:1024
    Content type: Research article Published on:

  3. Cancer patients have an increased risk of developing venous thromboembolism, with up to 30% dying within a month of their development. Some cancer cells are known to induce platelet aggregation, and this inter...

    Authors: Niamh McNamee, Laura Rodriguez de la Fuente, Maria Jose Santos-Martinez and Lorraine O’Driscoll
    Citation: BMC Cancer 2022 22:1023
    Content type: Research Published on:

  4. Salivary gland carcinomas (SGC) are extremely rare malignancies with only limited treatment options for the metastatic phase of the disease. Treatment with anti-CD47 antibodies could represent a potent therapy...

    Authors: Michal Votava, Robin Bartolini, Linda Capkova, Jitka Smetanova, Vachtenheim Jiri Jr, Martin Kuchar, David Kalfert, Jan Plzak, Jirina Bartunkova and Zuzana Strizova
    Citation: BMC Cancer 2022 22:1021
    Content type: Research Published on:

  5. Precision medicine highlights the importance of incorporating molecular genetic testing into standard clinical care. Next-generation sequencing can detect cancer-specific gene mutations, and molecular-targeted...

    Authors: Huita Wu, Haonan Ji, Wenhui Yang, Min Zhang, Yifang Guo, Bangkai Li, Jiayin Wang, Rongrong Chen, Yuan Chen and Xin Wang
    Citation: BMC Cancer 2022 22:1020
    Content type: Research Published on:

  7. Breast cancer (BC) and differentiated thyroid cancer (TC) are two common cancer types with the highest incidence in women. BC and TC can develop synchronous or metachronous and the occurrence of both is higher...

    Authors: Marceline W. Piek, Jan Paul de Boer, Frederieke van Duijnhoven, Jacqueline E. van der Wal, Menno Vriens, Rachel S. van Leeuwaarde and Iris M. C. van der Ploeg
    Citation: BMC Cancer 2022 22:1018
    Content type: Research Published on:

  8. Long noncoding RNAs (lncRNAs) are abnormally expressed in a broad type of cancers and play significant roles that regulate tumor development and metastasis. However, the pathological roles of lncRNAs in esopha...

    Authors: Hu Zhang, Enchun Pan, Ying Zhang, Chao Zhao, Qiwei Liu, Yuepu Pu and Lihong Yin
    Citation: BMC Cancer 2022 22:1017
    Content type: Research Published on:

  9. Bladder cancer (BLCA) is one of the most common genitourinary malignancies in the world, but its pathogenic genes have not been fully identified and the treatment outcomes are still unsatisfactory. Although th...

    Authors: Lijuan Gao, Ruimin Ren, Jing Shen, Jiayi Hou, Junya Ning, Yanlin Feng, Meiyue Wang, Lifei Wu, Yaojun Sun, Huang Wang, Deping Wang and Jimin Cao
    Citation: BMC Cancer 2022 22:1016
    Content type: Research Published on:

  10. Oncogenic Human Papillomaviruses (HPVs) base their transforming potential on the action of both E6 and E7 viral oncoproteins, which perform cooperative or antagonistic actions and thus interfere with a variety...

    Authors: María Paula Dizanzo, Marina Bugnon Valdano, Om Basukala, Lawrence Banks and Daniela Gardiol
    Citation: BMC Cancer 2022 22:1015
    Content type: Research Published on:

  12. Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) comprise several rare hematologic malignancies with shared concomitant dysplastic and proliferative clinicopathologic features of bone marrow failure and ...

    Authors: Tamara K. Moyo, Jason H. Mendler, Raphael Itzykson, Ashwin Kishtagari, Eric Solary, Adam C. Seegmiller, Aaron T. Gerds, Gregory D. Ayers, Amy E. Dezern, Aziz Nazha, Peter Valent, Arjan A. van de Loosdrecht, Francesco Onida, Lisa Pleyer, Blanca Xicoy Cirici, Raoul Tibes…
    Citation: BMC Cancer 2022 22:1013
    Content type: Study protocol Published on:

  13. The aim of this study was to investigate the effects of different thoracic radiotherapy doses on OS and incidence of radiation pneumonia which may provide some basis for optimizing the comprehensive treatment ...

    Authors: Hongyue Qin, Jiaojiao Ke, Shuai Dong, Huani Li, Kunli Zhu, Shuai Fu, Qian Shao and Zhenxiang Li
    Citation: BMC Cancer 2022 22:1012
    Content type: Research article Published on:

  14. Recently, the combination of the programmed death-ligand 1 (PD-L1) inhibitor atezolizumab with first-line chemotherapy has demonstrated to improve outcome for patients with advanced small cell lung cancer (SCL...

    Authors: Farastuk Bozorgmehr, Petros Christopoulos, Inn Chung, Jelena Cvetkovic, Manuel Feißt, Johannes Krisam, Marc A. Schneider, Claus Peter Heußel, Michael Kreuter, Daniel W. Müller, Michael Thomas and Stefan Rieken
    Citation: BMC Cancer 2022 22:1011
    Content type: Study protocol Published on:

  15. Stereotactic radiosurgery (SRS) has become a standard approach for the treatment of patients with few metastatic brain lesions. However, the optimal treatment approach for the use radiotherapy in the treatment...

    Authors: Zhengting Chen, Lingli Zhou, Min Zhao, Ke Cao, Yanqing Li, Xiaoling Liu, Yu Hou, Lan Li, Li Wang, Li Chang, Mei Yang, Wenhui Li and Yaoxiong Xia
    Citation: BMC Cancer 2022 22:1010
    Content type: Research Published on:

  16. Authors: Marina Mohallem Fonseca, Tasneem Alhassan, Yashmin Nisha, Diana Koszycki, Betty Anne Schwarz, Roanne Segal, Angel Arnaout, Tim Ramsay, Jacqueline Lau and Jean M. Seely
    Citation: BMC Cancer 2022 22:1009
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2022 22:774

  17. Adverse events of chemotherapy may be caused by pharmacodynamics or psychological factors such as negative expectations, which constitute nocebo effects. In a randomized controlled trial, we examined whether e...

    Authors: T. Michnevich, Y. Pan, A. Hendi, K. Oechsle, A. Stein and Y. Nestoriuc
    Citation: BMC Cancer 2022 22:1008
    Content type: Research Published on:

  18. No previous prospective research has explored the association of the TyG (fasting triglyceride-glucose) index and TG/HDL-C ratio as insulin resistance markers with the risk of colorectal cancer (CRC) incidence...

    Authors: Tong Liu, Qingsong Zhang, Yiming Wang, Xiangming Ma, Qi Zhang, Mengmeng Song, Liying Cao and Hanping Shi
    Citation: BMC Cancer 2022 22:1007
    Content type: Research Published on:

  19. Longitudinal, real-world data on the management of metastatic breast cancer is increasingly relevant to understand breast cancer care in routine clinical practice. Yet such data are scarce, particularly beyond...

    Authors: Henrik Lindman, Fredrik Wiklund and Klaus Kaae Andersen
    Citation: BMC Cancer 2022 22:1006
    Content type: Research Published on:

  20. Pyroptosis is a newly discovered form of cell programmed necrosis, but its role and mechanism in cancer cells remain unclear. The aim of this study is to systematically analyze the transcriptional sequencing d...

    Authors: Mingkai Gong, Xiangping Liu, Xian Zhao and Haibo Wang
    Citation: BMC Cancer 2022 22:1005
    Content type: Research Published on:

  21. This study aimed to explore whether collagen fiber features and collagen type I alpha 1 (COL1A1) are related to the stiffness of breast lesions and whether COL1A1 can predict axillary lymph node metastasis (LNM).

    Authors: Ying Jiang, Bo Wang, Jun Kang Li, Shi Yu Li, Rui Lan Niu, Nai Qin Fu, Jiao Jiao Zheng, Gang Liu and Zhi Li Wang
    Citation: BMC Cancer 2022 22:1004
    Content type: Research Published on:

  23. Approximately 40% of hormone receptor positive/human epidermal receptor 2 negative (HR + /HER2-) metastatic breast cancer (mBC) patients harbor phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit ...

    Authors: Mirko Fillbrunn, James Signorovitch, Fabrice André, Iris Wang, Ines Lorenzo, Antonia Ridolfi, Jinhee Park, Akanksha Dua and Hope S. Rugo
    Citation: BMC Cancer 2022 22:1002
    Content type: Research Published on:

  24. Despite the fact that tumor microenvironment (TME) and gene mutations are the main determinants of progression of the deadliest cancer in the world – lung cancer, their interrelations are not well understood. ...

    Authors: Alicja Rączkowska, Iwona Paśnik, Michał Kukiełka, Marcin Nicoś, Magdalena A. Budzinska, Tomasz Kucharczyk, Justyna Szumiło, Paweł Krawczyk, Nicola Crosetto and Ewa Szczurek
    Citation: BMC Cancer 2022 22:1001
    Content type: Research Published on:

  25. The objective of our study was to investigate changes over the past decade in patient age and the prevalence of HPV in the population of patients with oropharyngeal carcinoma (OPC) treated at our center.

    Authors: Philippe Gorphe, Pierre Blanchard, Gabriel C. T. E. Garcia, Marion Classe, Caroline Even, Stéphane Temam and Ingrid Breuskin
    Citation: BMC Cancer 2022 22:1000
    Content type: Research Published on:

  26. Little is known on the relationship between the expression of pyroptosis related genes (PRGs) and prognosis of hepatocellular carcinoma (HCC). In this study, a specific PRGs prognostic model was developed with...

    Authors: Guoxu Fang, Qinghua Zhang, Jianhui Fan, Haitao Li, Zongren Ding, Jun Fu, Yijun Wu, Yongyi Zeng and Jingfeng Liu
    Citation: BMC Cancer 2022 22:999
    Content type: Research Published on:

  28. Severe graft versus host disease (GVHD) is the main reason for non-relapse mortality following allogeneic hematopoietic cell transplantation (HCT). We investigated the serum protein profiles of patients who ha...

    Authors: Sook-Kyoung Heo, Eui-Kyu Noh, Yoo Jin Lee, Yerang Shin, Youjin Kim, Hyeon-Su Im, Hyeyeong Kim, Su Jin Koh, Young Joo Min, Jae-Cheol Jo and Yunsuk Choi
    Citation: BMC Cancer 2022 22:997
    Content type: Research Published on:

  29. Breast cancer patients undergoing chemotherapy treatment are at particular risk of experiencing acute cognitive impairment leading to daily challenges in decision-making and reduced quality of life and functio...

    Authors: Aline Hajj, Rita Khoury, Roula Hachem, Aya Awad, Souheil Hallit, Hala Sacre, Fady Nasr, Fadi El Karak, Georges Chahine, Joseph Kattan and Lydia Rabbaa Khabbaz
    Citation: BMC Cancer 2022 22:996
    Content type: Research Published on:

  31. Uptake of apoptotic cells induces a tolerogenic phenotype in phagocytes and promotes peripheral tolerance. The highly conserved Annexin core domain, present in all members of the Annexin family, becomes expose...

    Authors: Tobias Hein, Peter H. Krammer and Heiko Weyd
    Citation: BMC Cancer 2022 22:994
    Content type: Research article Published on:

  32. The human proteasome gene family (PSM) consists of 49 genes that play a crucial role in cancer proteostasis. However, little is known about the effect of PSM gene expression and genetic alterations on clinical...

    Authors: Peter Larsson, Daniella Pettersson, Hanna Engqvist, Elisabeth Werner Rönnerman, Eva Forssell-Aronsson, Anikó Kovács, Per Karlsson, Khalil Helou and Toshima Z. Parris
    Citation: BMC Cancer 2022 22:993
    Content type: Research Published on:

  33. The study aimed to compare efficacy and safety of various immune checkpoint inhibitors for patients with advanced or metastatic esophageal squamous cell carcinoma (ESCC).

    Authors: Tian-Tian Gao, Jia-Hui Shan, Yu-Xian Yang, Ze-Wei Zhang, Shi-Liang Liu, Mian Xi, Meng-Zhong Liu and Lei Zhao
    Citation: BMC Cancer 2022 22:992
    Content type: Research Published on:

  34. Colorectal cancer is the third most common cause of death among cancers in the world. Although improvements in various treatments have greatly improved the survival time of colorectal cancer patients, since co...

    Authors: Jun Xiang, Li Gao, Hao Yu Jing, Yun Xiao Liu, Hu Fei Wang, Ze Wen Chang, Shi Hao Liu, Lei Yu and Gui Yu Wang
    Citation: BMC Cancer 2022 22:991
    Content type: Research Published on:

  35. A group of genetically altered cells that have not transformed into a clinical or histologically identifiable state of malignancy but contains a higher risk of transforming into one is known as the field of ca...

    Authors: Shaheen Ahmed, Saeed Khan, Muhammad Asif Qureshi, Uzma Bukhari, Mehak Anis and Muhammad Nouman Mughal
    Citation: BMC Cancer 2022 22:990
    Content type: Research Published on:

  36. Radiotherapy of head-and-neck cancer (SCCHN) is often associated with acute toxicity. In a previous trial, daily reminders by staff members to perform skin care resulted in less dermatitis. This randomized tri...

    Authors: Dirk Rades, Inga Zwaan, Jon Cacicedo, Karl L. Bruchhage, Samer G. Hakim, Denise Olbrich, Steven E. Schild, Soeren Tvilsted and Stefan Janssen
    Citation: BMC Cancer 2022 22:989
    Content type: Research Published on:

  37. Anthracycline-induced cardiotoxicity is an irreversible cardiac cell injury. Therefore, it’s very important to identify influencing factors of anthracycline-induced subclinical cardiotoxicity (AISC). This stud...

    Authors: Qian Dong, Wenxin Ou, Mei Wang, Tiantian Jiang, Yue Weng, Xi Zhou and Xiaoqiong Tang
    Citation: BMC Cancer 2022 22:988
    Content type: Research Published on:

  38. Previous assessments of peritumoral inflammatory infiltrate in colorectal cancer (CRC) have focused on the role of CD8+ T lymphocytes. We sought to compare the prognostic value of CD8 with downstream indicators o...

    Authors: Luca Noti, José A. Galván, Heather Dawson, Alessandro Lugli, Richard Kirsch, Naziheh Assarzadegan, David Messenger, Philippe Krebs, Martin D. Berger and Inti Zlobec
    Citation: BMC Cancer 2022 22:987
    Content type: Research Published on:

  39. Glioblastoma (GBM) is the most aggressive type of brain tumor with heterogeneity and strong invasive ability. Treatment of GBM has not improved significantly despite the progress of immunotherapy and classical...

    Authors: Jin Myung Choi, Sa-Hoe Lim, Zhi-Peng Liu, Tae Kyu Lee, Joon Haeng Rhee, Mee Sun Yoon, Jung-Joon Min and Shin Jung
    Citation: BMC Cancer 2022 22:986
    Content type: Research Published on:

  40. Pediatric acute lymphoblastic leukemia (ALL) therapy is accompanied by treatment-related toxicities (TRTs) and impaired quality of life. In Australia and New Zealand, children with ALL are treated with either ...

    Authors: Clarissa E. Schilstra, Karen McCleary, Joanna E. Fardell, Mark W. Donoghoe, Emma McCormack, Rishi S. Kotecha, Richard De Abreu Lourenco, Shanti Ramachandran, Ruelleyn Cockcroft, Rachel Conyers, Siobhan Cross, Luciano Dalla-Pozza, Peter Downie, Tamas Revesz, Michael Osborn, Frank Alvaro…
    Citation: BMC Cancer 2022 22:985
    Content type: Research Published on:

  41. Malignant mesothelioma (MM) is an aggressive mesothelial cell cancer type linked mainly to asbestos inhalation. MM characterizes by rapid progression and resistance to standard therapeutic modalities such as s...

    Authors: Nguyen Truong Duc Hoang, Ghmkin Hassan, Tomoya Suehiro, Yuichi Mine, Tohru Matsuki and Makiko Fujii
    Citation: BMC Cancer 2022 22:984
    Content type: Research Published on:

  42. Cancer clinical trials (CCTs) are essential for cancer care, yet the evidence is scarce when it comes to racial disparities in CCT participation among cancer survivors in the Midwest. This study aimed to 1) as...

    Authors: Gaurav Kumar, Jungyoon Kim, Paraskevi A. Farazi, Hongmei Wang and Dejun Su
    Citation: BMC Cancer 2022 22:983
    Content type: Research Published on:

  43. EZH2 is mutated in nearly 25% of follicular lymphoma (FL) cases. Little is known about how EZH2 affects patients’ response to therapy. In this context, the aim of this study was to retrospectively analyze the fr...

    Authors: C. Martínez-Laperche, L. Sanz-Villanueva, F. J. Díaz Crespo, P. Muñiz, R. Martín Rojas, D. Carbonell, M. Chicano, J. Suárez-González, J. Menárguez, M. Kwon, J. L. Diez Martín, I. Buño and M. Bastos Oreiro
    Citation: BMC Cancer 2022 22:982
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2022 22:1224

  45. This study aimed to construct a nomogram to effectively predict the overall survival (OS) of patients with early-stage non-small-cell lung cancer (NSCLC).

    Authors: Liang Zhou, Yahui Zhang, Wenyu Chen, Niu Niu, Junjie Zhao, Weibo Qi and Yufen Xu
    Citation: BMC Cancer 2022 22:980
    Content type: Research Published on:

  46. Colorectal cancer is one of the most common cancer and the third leading cause of death worldwide. Increased generation of reactive oxygen species (ROS) is observed in many types of cancer cells. Several studi...

    Authors: Omid Cheraghi, Bahareh Dabirmanesh, Farideh Ghazi, Massoud Amanlou, Mona Atabakhshi-kashi, Yaghoub Fathollahi and Khosro Khajeh
    Citation: BMC Cancer 2022 22:979
    Content type: Research Published on:

  47. Cancer diagnoses and deaths among the elderly (65 +) are expected to increase significantly over the next decade. Immune checkpoint inhibitors specifically target ICI genes and enhance immune system function. ...

    Authors: Mohammed Safi, Chenxing Jin, Abdullah Aldanakh, Ping Feng, Henan Qin, Mohammed Alradhi, Lizhi Zhang, Junying Zhang, Salah Adlat, Yi Zhao and Jiwei Liu
    Citation: BMC Cancer 2022 22:978
    Content type: Research Published on:

  48. Granulocyte colony-stimulating factor (G-CSF)-producing lung cancer induces severe inflammation and a high white blood cell (WBC) count and is associated with poor prognosis. A recent case of G-CSF-producing l...

    Authors: Kazuhito Miyazaki, Aya Shiba, Toshiki Ikeda, Yuko Higashi, Masaharu Aga, Yusuke Hamakawa, Yuri Taniguchi, Yuki Misumi, Yoko Agemi, Yukiko Nakamura, Tsuneo Shimokawa and Hiroaki Okamoto
    Citation: BMC Cancer 2022 22:977
    Content type: Research Published on:

  49. Fatty acid synthase (FASN) expression is associated with a more aggressive breast cancer phenotype and is regulated downstream of receptor tyrosine kinase (RTK) signaling pathways. Recently, post transcription...

    Authors: Bryan McClellan, Paul Gries, Brittany Harlow, Stefano Tiziani, Christopher Jolly and Linda deGraffenried
    Citation: BMC Cancer 2022 22:976
    Content type: Research Published on:

  50. The modified nutritional geriatric risk index (mGNRI) was developed as a novel index and provides a more appropriate prognostic index than the original GNRI, which was reported to be a useful index for predict...

    Authors: Teruhisa Sakamoto, Teppei Sunaguchi, Keisuke Goto, Masaki Morimoto, Yuki Murakami, Kozo Miyatani, Takehiko Hanaki, Yuji Shishido, Kyoichi Kihara, Tomoyuki Matsunaga, Manabu Yamamoto, Naruo Tokuyasu and Yoshiyuki Fujiwara
    Citation: BMC Cancer 2022 22:974
    Content type: Research Published on:

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