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  1. Despite standard treatments including chemoradiotherapy with temozolomide (TMZ) (STUPP protocol), the prognosis of glioblastoma patients remains poor. AGuIX nanoparticles have a high radiosensitizing potential...

    Authors: Emilie Thivat, Mélanie Casile, Juliette Moreau, Ioana Molnar, Sandrine Dufort, Khalide Seddik, Géraldine Le Duc, Olivier De Beaumont, Markus Loeffler, Xavier Durando and Julian Biau
    Citation: BMC Cancer 2023 23:344
    Content type: Study Protocol Published on:

  2. Cells in every epithelium can be roughly divided in three compartments: stem cell (SC) compartment, transient amplifying cell (TA) compartment and terminally differentiated (TD) compartment. Maturation of stem...

    Authors: Benjamin Benzon, Sandra Marijan, Matij Pervan and Vedrana Čikeš Čulić
    Citation: BMC Cancer 2023 23:343
    Content type: Research Published on:

  3. This study aimed to investigate the effect of preoperative albumin-to-globulin ratio (AGR) on overall survival (OS) and health-related quality of life in patients with esophageal cell squamous carcinoma (ESCC).

    Authors: Juwei Zhang, Zheng Lin, Jinsong Zhou, Yue Huang, Siting Chen, Yuan Deng, Minglian Qiu, Yuanmei Chen and Zhijian Hu
    Citation: BMC Cancer 2023 23:342
    Content type: Research Published on:

  5. Preoperative evaluation of axillary lymph node (ALN) status is an essential part of deciding the appropriate treatment. According to ACOSOG Z0011 trials, the new goal of the ALN status evaluation is tumor burd...

    Authors: Yu Chen, Yongwei Xie, Bo Li, Hua Shao, Ziyue Na, Qiucheng Wang and Hui Jing
    Citation: BMC Cancer 2023 23:340
    Content type: Research Published on:

  6. Inherited mutations in the breast cancer susceptibility genes BRCA1 and BRCA2 (BRCA1/2) confer high risks of breast and ovarian cancer. Because the contribution of BRCA1/2 germline mutations to BC in the Northeas...

    Authors: Rahma Melki, Marouane Melloul, Souria Aissaoui, Tijani EL Harroudi and Noureddine Boukhatem
    Citation: BMC Cancer 2023 23:339
    Content type: Research Published on:

  7. Carcinoid heart disease is a rare disease which develops in patients with functional neuroendocrine tumors in an advanced tumor state. Patients diagnosed with carcinoid heart disease have a poor longtime progn...

    Authors: Eva Grundmann, Alessandra Curioni-Fontecedro, Emanuel Christ and Alexander R. Siebenhüner
    Citation: BMC Cancer 2023 23:338
    Content type: Research Published on:

  8. The utilization of stereotactic body radiation therapy (SBRT) is increasing for primary and secondary lung neoplasms. Despite encouraging results, SBRT is associated with an increased risk of osteoradionecrosi...

    Authors: Michael P. Carducci, Baskaran Sundaram, Benjamin A. Greenberger, Maria Werner-Wasik and Gregory C. Kane
    Citation: BMC Cancer 2023 23:337
    Content type: Research Published on:

  9. Colorectal cancer (CRC) is a common disease threatening human lives worldwide, and vitamin D receptor (VDR) contributes protective roles in this disease. However, the molecular mechanisms underlying VDR protec...

    Authors: Jie Yu, Qi Sun, Yi Hui, Jinping Xu, Pancheng Shi, Yu Chen and Yunzhao Chen
    Citation: BMC Cancer 2023 23:336
    Content type: Research Published on:

  10. Peroxisome proliferator activated receptors (PPARs) are a nuclear hormone receptors superfamily that is closely related to fatty acid (FA) metabolism and tumor progression. Solute carrier family 27 member 2 (SLC2...

    Authors: Kun Shang, Nina Ma, Juanjuan Che, Huihui Li, Jiexuan Hu, Haolin Sun and Bangwei Cao
    Citation: BMC Cancer 2023 23:335
    Content type: Research Published on:

  11. Periampullary cancer is a term for cancers arising in or in close proximity to the pancreas. Pancreatic cancer is the 3rd leading cause of cancer death for both sexes and while surgery is the only option for cure...

    Authors: Sofie Olsson Hau, Caroline Williamsson, Bodil Andersson, Jakob Eberhard and Karin Jirström
    Citation: BMC Cancer 2023 23:334
    Content type: Research Published on:

  12. Leptomeningeal metastasis (LM) is the most devastating complication of non-small cell lung cancer (NSCLC), and its incidence is increasing. There is currently no standard treatment for LM, and the efficacy of ...

    Authors: Tao Zhou, Shaofeng Zhu, Qiang Xiong, Jiongli Gan, Jianping Wei, Jing Cai and Anwen Liu
    Citation: BMC Cancer 2023 23:333
    Content type: Research Published on:

  13. The Arias-Stella reaction is a hormone-related atypical endometrial change characterized by cytomegaly, nuclear enlargement, and hyperchromasia of endometrial glands; typically associated with intrauterine or ...

    Authors: Fatemeh Nili, Masoumeh Sadri and Fereshteh Ameli
    Citation: BMC Cancer 2023 23:332
    Content type: Research Published on:

  14. As a potential target receptor tyrosine kinase, mesenchymal-epithelial transition factor (MET) exhibits high aberrant expression across various tumors. This study aimed to evaluated the safety, tolerability, effi...

    Authors: Xingsheng Hu, Xinge Cui, Ziping Wang, Yunpeng Liu, Ying Luo, Wei Zhong, Hui Zhao, Mengxing Yao, Da Jiang, Mingxia Wang, Minjiang Chen, Xin Zheng, Lieming Ding, Yang Wang, Xiaobin Yuan, Pengxiang Wu…
    Citation: BMC Cancer 2023 23:331
    Content type: Research Published on:

  15. Progesterone receptor (PR)-negative tumors have been shown to have worse prognosis and were underrepresented in recent trials on patients with estrogen receptor (ER)-positive breast cancer. The role of PR-nega...

    Authors: Sung Jun Ma, Jasmin Gill, Keerti Yendamuri, Udit Chatterjee, Olivia Waldman, Cynthia Dunne-Jaffe, Fatemeh Fekrmandi, Rohil Shekher, Austin Iovoli, Song Yao, Oluwadamilola T. Oladeru and Anurag K. Singh
    Citation: BMC Cancer 2023 23:330
    Content type: Research Published on:

  16. Most cases of lung cancer are diagnosed at advanced stage. Detection of genetic and epigenetic markers in cell-free DNA (cfDNA) is a promising tool for the diagnosis of lung cancer at an early stage. The aim o...

    Authors: Abla Abou-Zeid, Doaa Hashad, Ayman Baess, Mai Mosaad and Eman Tayae
    Citation: BMC Cancer 2023 23:329
    Content type: Research Published on:

  17. DTL has been found to be related with multiple cancers. However, comprehensive analyses, which identify the prediction value of DTL in diagnosis, prognosis, immune infiltration and treatment, have rarely been ...

    Authors: Yumei Tang, Ye Lei, Peng Gao, Junting Jia, Huijun Du, Qitong Wang, Zhixin Yan, Chen Zhang, Guojun Liang, Yanfeng Wang, Weijun Ma, Nianzeng Xing, Le Cheng and Laifeng Ren
    Citation: BMC Cancer 2023 23:328
    Content type: Research Published on:

  18. Neoadjuvant chemoradiotherapy (nCRT) followed by esophagectomy is a standard treatment for potentially curable esophageal cancer. Active surveillance in patients with a clinically complete response (cCR) 12 we...

    Authors: Charlène J. van der Zijden, Sjoerd M. Lagarde, Merel Hermus, Leonieke W. Kranenburg, J. Jan B. van Lanschot, Bianca Mostert, Joost J. M. E. Nuyttens, Lindsey Oudijk, Pieter C. van der Sluis, Manon C. W. Spaander, Maria J. Valkema, Roelf Valkema and Bas P. L. Wijnhoven
    Citation: BMC Cancer 2023 23:327
    Content type: Study protocol Published on:

  19. Despite immunotherapy’s promise in oncology, its use for sarcoma remains challenging. There are no sarcoma-specific biomarkers for immune checkpoint inhibitors (ICI). Previously, we reported our institutional ...

    Authors: Marium Husain, Dionisia Quiroga, Han Gil Kim, Scott Lenobel, Menglin Xu, Hans Iwenofu, James L. Chen, Claire Verschraegen, David Liebner and Gabriel Tinoco
    Citation: BMC Cancer 2023 23:326
    Content type: Research Published on:

  20. The survival benefit of adjuvant transarterial chemoembolization (TACE) in patients with hepatectomy for hepatocellular carcinoma (HCC) after hepatectomy remains controversial. We aimed to investigate the surv...

    Authors: Zhao Wu, Lifeng Cui, Junlin Qian, Laihui Luo, Shuju Tu, Fei Cheng, Lebin Yuan, WenJian Zhang, Wei Lin, Hongtao Tang, Xiaodong Li, Hui Li, Yang Zhang, Jisheng Zhu, Yong Li, Yuanpeng Xiong…
    Citation: BMC Cancer 2023 23:325
    Content type: Research Published on:

  21. To evaluate prognostic significance of human papillomavirus (HPV) in hypopharyngeal squamous cell carcinoma patients, and to investigate the effect of p53 and TP53 mutations on the prognosis of patients.

    Authors: Qiang Huang, Feiran Li, Mengyou Ji, Lan Lin and Chunyan Hu
    Citation: BMC Cancer 2023 23:324
    Content type: Research Published on:

  22. Colorectal cancer (CRC) is one of the most prevalent types of malignant tumours. Metastasis is the leading cause of cancer-related mortality, with lung metastases accounting for 32.9% of all metastatic CRCs. H...

    Authors: Wei Dai, Caiyao Guo, Yu Wang, Yumei Li, Renjian Xie, Junhong Wu, Baole Yao, Dong Xie, Ling He, Yingying Li, Hao Huang, Yun Wang and Shenglan Liu
    Citation: BMC Cancer 2023 23:323
    Content type: Research Published on:

  23. Essential elements have functions in tumor progression by promoting protumoral cellular processes, such as proliferation, and migration, among others. Obtaining an understanding of how these elements relate to...

    Authors: Samella Salles, Rebecca Salles, Mauro S. G. Pavão, Simone C. Cardoso and Mariana P. Stelling
    Citation: BMC Cancer 2023 23:322
    Content type: Research Published on:

  24. Ovarian cancer is one of the most lethal cancers in women because it is often diagnosed at an advanced stage. The molecular markers investigated thus far have been unsatisfactory.

    Authors: Jianxiong Li, Huaguo Liang, Wentao Xiao, Peng Wei, Hongmei Chen, Zexin Chen, Ruihui Yang, Huan Jiang and Yongli Zhang
    Citation: BMC Cancer 2023 23:321
    Content type: Research Published on:

  25. Bladder cancer is the tenth most common cancer worldwide. For patients with T1 high-grade or T2 bladder cancer, radical cystectomy is recommended. However, radical cystectomy is associated with various complic...

    Authors: Xiangwei Yang, Shiqiang Zhang, Yajiao Cui, Yamei Li, Xinyue Song and Jun Pang
    Citation: BMC Cancer 2023 23:320
    Content type: Study Protocol Published on:

  26. Numerous studies have reported the prognostic significance of the red cell distribution width (RDW) in patients with esophageal squamous cell carcinoma (ESCC), but the relationship between the perioperative ch...

    Authors: Peng Zhang, Sheng Wang, Jun-zhou Wu and Qian Song
    Citation: BMC Cancer 2023 23:319
    Content type: Research Published on:

  27. Immunotherapy has made significant advances in the treatment of extensive-stage small-cell lung cancer (ES-SCLC), but data in combination with radiotherapy are scarce. This study aims to assess the safety and ...

    Authors: Lijuan Li, Dan Yang, Yanmei Min, Anyan Liao, Jing Zhao, Leilei Jiang, Xin Dong, Wei Deng, Huiming Yu, Rong Yu, Jun Zhao and Anhui Shi
    Citation: BMC Cancer 2023 23:318
    Content type: Research Published on:

  28. Steady evolution of therapies has improved prognosis of patients with multiple myeloma (MM) over the past two decades. Yet, knowledge about survival trends and causes of death in MM might play a crucial role i...

    Authors: Christine Eisfeld, Hiltraud Kajüter, Lennart Möller, Ina Wellmann, Evgenii Shumilov and Andreas Stang
    Citation: BMC Cancer 2023 23:317
    Content type: Research Published on:

  29. Drug-induced interstitial lung disease (ILD) is not a rare adverse event in the current chemotherapy strategy for pancreatic ductal adenocarcinoma (PDAC). Thus, we aimed to find the optimal management for PDAC...

    Authors: Hiroki Irie, Rei Suzuki, Yoshinori Okubo, Hiroyuki Asama, Naoki Konno, Yuki Noguchi, Ko Watanabe, Goro Shibukawa, Hidemichi Imamura, Tadayuki Takagi, Mitsuru Sugimoto, Yuki Sato, Jun Nakamura, Tsunetaka Kato, Minami Hashimoto, Takumi Yanagita…
    Citation: BMC Cancer 2023 23:316
    Content type: Research Published on:

  30. DNA methylation is one of the most promising biomarkers in predicting the prognosis of colorectal cancer (CRC). We aimed to develop a DNA methylation biomarker that could evaluate the prognosis of CRC.

    Authors: Xuan Li, Du Cai, Yaoyi Huang, Yumo Xie, Dingcheng Shen, Ze Yuan, Xiaoxia Liu, Meijin Huang, Yanxin Luo, Huichuan Yu and Xiaolin Wang
    Citation: BMC Cancer 2023 23:315
    Content type: Research Published on:

  31. Cancer of Unknown Primary (CUP) is metastatic cancer with an unidentifiable primary tumour origin during life. It remains difficult to study the occurrence and aetiology of CUP. Hitherto, it is unclear whether...

    Authors: Karlijn E. P. E. Hermans, Fatemeh Kazemzadeh, Caroline Loef, Rob L. H. Jansen, Iris D. Nagtegaal, Piet A. van den Brandt and Leo J. Schouten
    Citation: BMC Cancer 2023 23:314
    Content type: Research Published on:

  32. Genomic alterations, including loss of function in chromosome band 11q22-23, are frequently observed in neuroblastoma, which is the most common extracranial childhood tumour. In neuroblastoma, ATM, a DNA damage r...

    Authors: Sultana Parvin, Jesmin Akter, Hisanori Takenobu, Yutaka Katai, Shunpei Satoh, Ryu Okada, Masayuki Haruta, Kyosuke Mukae, Tomoko Wada, Miki Ohira, Kiyohiro Ando and Takehiko Kamijo
    Citation: BMC Cancer 2023 23:313
    Content type: Research Published on:

  33. Pulmonary large cell neuroendocrine carcinoma (LCNEC) and small cell lung cancer (SCLC) are two types of high-grade neuroendocrine carcinomas of the lung with poor prognosis. LCNEC has not been thoroughly stud...

    Authors: Liling Huang, Yu Feng, Tongji Xie, Haohua Zhu, Le Tang and Yuankai Shi
    Citation: BMC Cancer 2023 23:312
    Content type: Research Published on:

  34. Cancer is becoming an important public health problem in Uganda. Cancer control requires surveillance of lifestyle risk factors to inform targeted interventions. However, only one national Non-Communicable Dis...

    Authors: Annet Nakaganda, Immaculate Mbarusha, Angela Spencer, Lesley Patterson, Isla Gemmell, Andrew Jones and Arpana Verma
    Citation: BMC Cancer 2023 23:311
    Content type: Research Published on:

  35. Pediatric cancer is the leading cause of disease-related death in children and the need for better therapeutic options remains urgent. Due to the limited number of patients, target and drug development for ped...

    Authors: Kaylee M. Keller, Joost Koetsier, Linda Schild, Vicky Amo-Addae, Selma Eising, Kim van den Handel, Kimberley Ober, Bianca Koopmans, Anke Essing, Marlinde L. van den Boogaard, Karin P. S. Langenberg, Natalie Jäger, Marcel Kool, Stefan Pfister, M. Emmy M. Dolman, Jan J. Molenaar…
    Citation: BMC Cancer 2023 23:310
    Content type: Research Published on:

  36. Metastatic castration-resistant prostate cancer (mCRPC) remains a therapeutic challenge and evidence for late-line treatments in real-life is limited. The present study investigates the efficacy and safety of ...

    Authors: Mustafa Asowed, Nils O Elander, Linn Pettersson, Maria Ekholm and Dimitrios Papantoniou
    Citation: BMC Cancer 2023 23:309
    Content type: Research Published on:

  37. The Neo-REGATTA study evaluated the effectiveness and safety of Docetaxel, oxaliplatin, and S-1 (DOS regimen) followed by radical resection vs. chemotherapy in advanced gastric adenocarcinoma patients with sin...

    Authors: Yuehong Cui, Yiyi Yu, Song Zheng, Jie’er Ying, Yi’an Du, Yan Wang, Xuefei Wang, Zhenbin Shen, Fenglin Liu, Minzhi Lv, Yihong Sun and Tianshu Liu
    Citation: BMC Cancer 2023 23:308
    Content type: Research Published on:

  39. Lovastatin, an HMG-CoA inhibitor and an effective cholesterol lowering drug, exhibits anti-neoplastic activity towards several types of cancer, although the underlying mechanism is still not fully understood. ...

    Authors: Jian Gao, Jifen Hu, Fang Yu, Chunlin Wang, Danmei Sheng, Wuling Liu, Anling Hu, Kunling Yu, Xiao Xiao, Yi Kuang, Eldad Zacksenhaus, Babu Gajendran and Yaacov Ben-David
    Citation: BMC Cancer 2023 23:306
    Content type: Research Published on:

  40. Recurrence and metastases are still frequent outcomes after initial tumour control in women diagnosed with breast cancer. Although therapies are selected based on tumour characteristics measured at baseline, p...

    Authors: Alexandre Prieur, Andrew Harper, Momtafin Khan, Bérengère Vire, Dominique Joubert, Léa Payen and Karen Kopciuk
    Citation: BMC Cancer 2023 23:305
    Content type: Research Published on:

  41. Colorectal cancer survivors often experience decline in physical performance and poor quality of life after surgery and during adjuvant therapies. In these patients, preserving skeletal muscle mass and high-qu...

    Authors: Inah Kim, Ji Young Lim, Sun Woo Kim, Dong Wook Shin, Hee Cheol Kim, Yoon Ah Park, Yoon Suk Lee, Jung-Myun Kwak, Seok Ho Kang, Ji Youl Lee and Ji Hye Hwang
    Citation: BMC Cancer 2023 23:304
    Content type: Study protocol Published on:

  42. Nonerythrocytic spectrin beta 1 (SPTBN1) is an important cytoskeletal protein that involves in normal cell growth and development via regulating TGFβ/Smad signaling pathway, and is aberrantly expressed in vari...

    Authors: Wenting Tang, Qiong Shao, Zhanwen He, Xu Zhang, Xiaojuan Li and Ruohao Wu
    Citation: BMC Cancer 2023 23:303
    Content type: Research Published on:

  43. Talin-1 as a component of multi-protein adhesion complexes plays a role in tumor formation and migration in various malignancies. This study investigated Talin-1 in protein levels as a potential prognosis biom...

    Authors: Yasaman Rezaie, Fahimeh Fattahi, Baharnaz Mashinchi, Kambiz Kamyab Hesari, Sahar Montazeri, Elham Kalantari, Zahra Madjd and Leili Saeednejad Zanjani
    Citation: BMC Cancer 2023 23:302
    Content type: Research Published on:

  44. As a common malignant tumor, esophageal carcinoma (ESCA) has a low early diagnosis rate and poor prognosis. This study aimed to construct the prognostic features composed of ZNF family genes to effectively pre...

    Authors: Kunqiao Hong, Qian Yang, Haisen Yin, Na Wei, Wei Wang and Baoping Yu
    Citation: BMC Cancer 2023 23:301
    Content type: Research Published on:

  45. Physical activity and BMI have been individually associated with cancer survivorship but have not yet been studied in combinations in colorectal cancer patients. Here, we investigate individual and combined as...

    Authors: Caroline Himbert, Jennifer Ose, Biljana Gigic, Richard Viskochil, Kelly Santuci, Tengda Lin, Anjelica Ashworth, Jessica N. Cohan, Courtney L. Scaife, Jolanta Jedrzkiewicz, Victoria Damerell, Katelyn M. Atkins, Jun Gong, Matthew G. Mutch, Corey Bernadt, Seth Felder…
    Citation: BMC Cancer 2023 23:300
    Content type: Research Published on:

  46. Multiparametric magnetic resonance imaging (mMRI) is the modality of choice in the imaging of ovarian cancer (OC). We aimed to investigate the feasibility of different types of regions of interest (ROIs) in th...

    Authors: Milja Reijonen, Erikka Holopainen, Otso Arponen, Mervi Könönen, Ritva Vanninen, Maarit Anttila, Hanna Sallinen, Irina Rinta-Kiikka and Auni Lindgren
    Citation: BMC Cancer 2023 23:299
    Content type: Research Published on:

  47. We have previously reported that Toll-like receptor 3 (TLR3) acts as a suppressor gene for breast cancer initiation and progression. In this study, we evaluated the role of TLR3 in breast cancer using our origina...

    Authors: Lei Fan, Xin-Yi Sui, Xi Jin, Wen-Juan Zhang, Peng Zhou and Zhi-Ming Shao
    Citation: BMC Cancer 2023 23:298
    Content type: Research Published on:

  48. To assess construct validity and responsiveness of the Expanded Prostate Cancer Index Composite Instrument (EPIC-26) relative to the Short-Form Six-Dimension (SF-6D) and Assessment of Quality of Life 6-Dimensi...

    Authors: Norma B. Bulamu, Christine Mpundu-Kaambwa, Michael O’Callaghan and Billingsley Kaambwa
    Citation: BMC Cancer 2023 23:297
    Content type: Research Published on:

  49. The prognostic value of cytokeratin 19 fragment (CYFRA 21 − 1) and Ki67 in advanced non-small cell lung cancer (NSCLC) patients with wild-type epidermal growth factor receptor (EGFR) remains to be explored.

    Authors: Tao Li, Qi Xie, Yang-Yang Fang, Yi Sun, Xiao Ming Wang, Zhu Luo, Gui-Ling Yan, Jian-Bo He and Xiao-Qun Zheng
    Citation: BMC Cancer 2023 23:295
    Content type: Research Published on:

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