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  1. Prostate cancer that has recurred after local therapy or disseminated distantly is usually treated with androgen deprivation therapy; however, most men will eventually experience disease progression within 12 ...

    Authors: Eric Winquist, Tricia Waldron, Scott Berry, D Scott Ernst, Sébastien Hotte and Himu Lukka
    Citation: BMC Cancer 2006 6:112
    Content type: Research article Published on:

  2. The poly Q polymorphism in AIB1 (amplified in breast cancer) gene is usually assessed by fragment length analysis which does not reveal the actual sequence variation. The purpose of this study is to investigate t...

    Authors: Lee-Jun C Wong, Pu Dai, Jyh-Feng Lu, Mary Ann Lou, Robert Clarke and Viktor Nazarov
    Citation: BMC Cancer 2006 6:111
    Content type: Research article Published on:

  4. Our previous cDNA array results indicated KIAA0101 as one of the differentially expressed genes in human hepatocellular carcinoma (HCC) as compared with non-cancerous liver. However, it is necessary to study i...

    Authors: Minglei Guo, Jinjun Li, Dafang Wan and Jianren Gu
    Citation: BMC Cancer 2006 6:109
    Content type: Research article Published on:

  5. ACTH overproduction within the pituitary gland or ectopically leads to hypercortisolism. Here, we report the first case of Cushing' syndrome caused by an ectopic ACTH-secreting neuroendocrine carcinoma of the ...

    Authors: Mathias Fasshauer, Thomas Lincke, Helmut Witzigmann, Regine Kluge, Andrea Tannapfel, Michael Moche, Michael Buchfelder, Stephan Petersenn, Juergen Kratzsch, Ralf Paschke and Christian A Koch
    Citation: BMC Cancer 2006 6:108
    Content type: Case report Published on:

  6. New cancer therapeutic strategies must be investigated that enhance prostate cancer treatment while minimizing associated toxicities. We have previously shown that genistein, the major isoflavone found in soy,...

    Authors: Julian J Raffoul, Yu Wang, Omer Kucuk, Jeffrey D Forman, Fazlul H Sarkar and Gilda G Hillman
    Citation: BMC Cancer 2006 6:107
    Content type: Research article Published on:

  8. SSeCKS is a major protein kinase C substrate with kinase scaffolding and metastasis-suppressor activity whose expression is severely downregulated in Src- and Ras-transformed fibroblast and epithelial cells an...

    Authors: Yongzhong Liu, Lingqiu Gao and Irwin H Gelman
    Citation: BMC Cancer 2006 6:105
    Content type: Research article Published on:

  9. Mathematical models of cancer relevant processes are being developed at an increasing rate. Conceptual frameworks are needed to support new treatment designs based on such models.

    Authors: Tomas Radivoyevitch, Kenneth A Loparo, Robert C Jackson and W David Sedwick
    Citation: BMC Cancer 2006 6:104
    Content type: Research article Published on:

  11. Twenty years after the nuclear accident in Chernobyl (Eastern Europe), there is still a controversial debate concerning a possible effect of the radioactive iodines, especially I-131, on the increase of thyroi...

    Authors: René Scheiden, Marc Keipes, Carlo Bock, Walter Dippel, Nelly Kieffer and Catherine Capesius
    Citation: BMC Cancer 2006 6:102
    Content type: Research article Published on:

  13. While there is enough convincing evidence in childhood acute lymphoblastic leukemia (ALL), the data on the pre-natal origin in childhood acute myeloid leukemia (AML) are less comprehensive. Our study aimed to ...

    Authors: Tatiana Burjanivova, Jozef Madzo, Katerina Muzikova, Claus Meyer, Bjoern Schneider, Felix Votava, Rolf Marschalek, Jan Stary, Jan Trka and Jan Zuna
    Citation: BMC Cancer 2006 6:100
    Content type: Research article Published on:

  14. Searches for differentially expressed genes in tumours have made extensive use of array technology. Most samples have been obtained from tumour biopsies or from established tumour-derived cell lines. Here we c...

    Authors: Mariana Fernandez-Cobo, James F Holland and Beatriz GT Pogo
    Citation: BMC Cancer 2006 6:99
    Content type: Research article Published on:

  15. A critical choice facing breast cancer patients is which surgical treatment – mastectomy or breast conserving surgery (BCS) – is most appropriate. Several studies have investigated factors that impact the type...

    Authors: Michael A Martin, Ramona Meyricke, Terry O'Neill and Steven Roberts
    Citation: BMC Cancer 2006 6:98
    Content type: Research article Published on:

  16. We previously identified brain type fatty acid-binding protein (FABP7) as a prognostic marker for patients with glioblastoma (GBM). Increased expression of FABP7 is associated with reduced survival. To investi...

    Authors: Yu Liang, Andrew W Bollen, Ken D Aldape and Nalin Gupta
    Citation: BMC Cancer 2006 6:97
    Content type: Research article Published on:

  17. Genomic DNA copy number aberrations are frequent in solid tumors, although the underlying causes of chromosomal instability in tumors remain obscure. Genes likely to have genomic instability phenotypes when mu...

    Authors: Jane Fridlyand, Antoine M Snijders, Bauke Ylstra, Hua Li, Adam Olshen, Richard Segraves, Shanaz Dairkee, Taku Tokuyasu, Britt Marie Ljung, Ajay N Jain, Jane McLennan, John Ziegler, Koei Chin, Sandy Devries, Heidi Feiler, Joe W Gray…
    Citation: BMC Cancer 2006 6:96
    Content type: Research article Published on:

  19. Human papilloma virus (HPV) in patients with esophageal carcinoma has previously been studied with an average detection rate of 15%, but the role of HPV in relation to survival is less clear. In cervical cance...

    Authors: Martin Dreilich, Michael Bergqvist, Martin Moberg, Daniel Brattström, Inger Gustavsson, Stefan Bergström, Alkwin Wanders, Patrik Hesselius, Gunnar Wagenius and Ulf Gyllensten
    Citation: BMC Cancer 2006 6:94
    Content type: Research article Published on:

  20. The roles of mitochondria in energy metabolism, the generation of ROS, aging, and the initiation of apoptosis have implicated their importance in tumorigenesis. In this study we aim to establish the mutation s...

    Authors: Duan-Jun Tan, Julia Chang, Ling-Ling Liu, Ren-Kui Bai, Yu-Fen Wang, Kun-Tu Yeh and Lee-Jun C Wong
    Citation: BMC Cancer 2006 6:93
    Content type: Research article Published on:

  21. A considerable proportion of estrogen receptor (ER)-positive breast cancer recurs despite tamoxifen treatment, which is a serious problem commonly encountered in clinical practice. We tried to find novel progn...

    Authors: Wonshik Han, Mi-Ryung Han, Jason Jongho Kang, Ji-Yeon Bae, Ji Hyun Lee, Young Ju Bae, Jeong Eon Lee, Hyuk-Jae Shin, Ki-Tae Hwang, Sung-Eun Hwang, Sung-Won Kim and Dong-Young Noh
    Citation: BMC Cancer 2006 6:92
    Content type: Research article Published on:

  22. Ribosomal proteins are the components of ribosome, which also exhibit various secondary functions in DNA repair, apoptosis, drug resistance and proliferation. In our previous study of microarray, ribosomal pro...

    Authors: Hui Wang, Li-Na Zhao, Kai-Zong Li, Rui Ling, Xiao-Jun Li and Ling Wang
    Citation: BMC Cancer 2006 6:91
    Content type: Research article Published on:

  23. WT1 is a tumor suppressor gene responsible for Wilms' tumor. WT1 reactivity is limited to ovarian serous carcinomas. Recent studies have shown that WT1 plays an important role in the progression of disease and...

    Authors: Wirote Netinatsunthorn, Jitti Hanprasertpong, Chavaboon Dechsukhum, Roengsak Leetanaporn and Alan Geater
    Citation: BMC Cancer 2006 6:90
    Content type: Research article Published on:

  24. Epigenetic changes during ageing and their relationship with cancer are under the focus of intense research. RASSF1A and NORE1A are novel genes acting in concert in the proapoptotic pathway of the RAS signalling....

    Authors: Sonia Di Gioia, Paolo Bianchi, Annarita Destro, Fabio Grizzi, Alberto Malesci, Luigi Laghi, Massimo Levrero, Alberto Morabito and Massimo Roncalli
    Citation: BMC Cancer 2006 6:89
    Content type: Research article Published on:

  25. Mammaglobin A (SCGB2A2) and lipophilin B (SCGB1D2), two members of the secretoglobin superfamily, are known to be co-expressed in breast cancer, where their proteins form a covalent complex. Based on the relative...

    Authors: Menelaos Zafrakas, Beate Petschke, Andreas Donner, Florian Fritzsche, Glen Kristiansen, Ruth Knüchel and Edgar Dahl
    Citation: BMC Cancer 2006 6:88
    Content type: Research article Published on:

  26. Hematopoietic stem cell transplantation is being increasingly used in cancer therapy. Diffuse alveolar hemorrhage, an early complication of stem cell transplant, results from bacterial, viral and fungal infect...

    Authors: Sachin Gupta, Amit Jain, Tina V Fanning, Daniel R Couriel, Carlos A Jimenez and Georgie A Eapen
    Citation: BMC Cancer 2006 6:87
    Content type: Case report Published on:

  27. Sensitivity of breast tumors to anticancer drugs depends upon dynamic interactions between epithelial tumor cells and their microenvironment including stromal cells and extracellular matrix. To study drug-sens...

    Authors: Heiko van der Kuip, Thomas E Mürdter, Maike Sonnenberg, Monika McClellan, Susanne Gutzeit, Andreas Gerteis, Wolfgang Simon, Peter Fritz and Walter E Aulitzky
    Citation: BMC Cancer 2006 6:86
    Content type: Technical advance Published on:

  29. Prospective investigations of complete decongestive lymphatic physiotherapy (CDPT), including manual lymphatic drainage (MLD), have validated the efficacy of these interventions for the initial reduction of ed...

    Authors: Olivia Wilburn, Paul Wilburn and Stanley G Rockson
    Citation: BMC Cancer 2006 6:84
    Content type: Research article Published on:

  30. Colorectal cancer (CRC), which has become especially prevalent in developed countries, is currently the third highest cause of cancer mortality in Taiwan. Mutation of the adenomatous polyposis coli (APC) gene, a ...

    Authors: Shee-Ping Chen, Shih-Tzu Tsai, Shu-Wen Jao, Yen-Lun Huang, Yu-Chen Chao, Yi-Lin Chen, Chang-Chieh Wu, Shinn-Zong Lin and Horng-Jyh Harn
    Citation: BMC Cancer 2006 6:83
    Content type: Research article Published on:

  32. At many centres tumour markers are used to detect disease recurrence and to monitor response to therapy in patients with advanced disease, although the real value of serial observation of marker levels remains...

    Authors: Rupert Bartsch, Catharina Wenzel, Ursula Pluschnig, Dagmar Hussian, Ursula Sevelda, Gabriela Altorjai, Gottfried J Locker, Robert Mader, Christoph C Zielinski and Guenther G Steger
    Citation: BMC Cancer 2006 6:81
    Content type: Research article Published on:

  33. The MDM2 gene encodes a negative regulator of the p53 tumour suppressor protein. A single nucleotide polymorphism (SNP) in the MDM2 promoter (a T to G exchange at nucleotide 309) has been reported to produce a...

    Authors: Ellen R Copson, Helen E White, Jeremy P Blaydes, David O Robinson, Peter W Johnson and Diana M Eccles
    Citation: BMC Cancer 2006 6:80
    Content type: Research article Published on:

  34. Several small receptor tyrosine kinase inhibitors (RTKI) have entered clinical cancer trials alone and in combination with radiotherapy or chemotherapy. The inhibitory spectrum of these compounds is often not ...

    Authors: Minglun Li, Gong Ping, Christian Plathow, Thuy Trinh, Kenneth E Lipson, Kai Hauser, Robert Krempien, Juergen Debus, Amir Abdollahi and Peter E Huber
    Citation: BMC Cancer 2006 6:79
    Content type: Research article Published on:

  35. This article aims to explain the reasons for the remarkable change in age of breast cancer occurrence in the Swiss canton of Geneva.

    Authors: Christine Bouchardy, Alfredo Morabia, Helena M Verkooijen, Gérald Fioretta, Yves Wespi and Peter Schäfer
    Citation: BMC Cancer 2006 6:78
    Content type: Research article Published on:

  36. Metastasis is a major cause of morbidity and mortality in breast cancer with tumor cell invasion playing a crucial role in the metastatic process. PDK1 is a key molecule that couples PI3K to cell proliferation...

    Authors: Zhihui Xie, Hongyan Yuan, Yuzhi Yin, Xiao Zeng, Renkui Bai and Robert I Glazer
    Citation: BMC Cancer 2006 6:77
    Content type: Research article Published on:

  37. Patients with metastatic breast cancer are frequently treated with anthracyclines and taxanes, which are among the most active agents in this disease. Gemcitabine is an interesting candidate for a three-drug c...

    Authors: Alessandro Passardi, Ilaria Massa, Wainer Zoli, Lorenzo Gianni, Carlo Milandri, Federica Zumaglini, Oriana Nanni, Roberta Maltoni, Giovanni Luca Frassineti and Dino Amadori
    Citation: BMC Cancer 2006 6:76
    Content type: Research article Published on:

  38. CD40L was found to reduce doxorubicin-induced apoptosis in non Hodgkin's lymphoma cell lines through caspase-3 dependent mechanism. Whether this represents a general mechanism for other tumor types is unknown.

    Authors: Nathalie Voorzanger-Rousselot, Laurent Alberti and Jean-Yves Blay
    Citation: BMC Cancer 2006 6:75
    Content type: Research article Published on:

  39. Basic studies of oncogenesis have demonstrated that either the elevated production of particular oncogene proteins or the occurrence of qualitative abnormalities in oncogenes can contribute to neoplastic cellu...

    Authors: Hong Namkoong, Seung Min Shin, Hyun Kee Kim, Seon-Ah Ha, Goang Won Cho, Soo Young Hur, Tae Eung Kim and Jin Woo Kim
    Citation: BMC Cancer 2006 6:74
    Content type: Research article Published on:

  40. Molecular markers identifying alterations in proliferation and apoptotic pathways could be particularly important in characterizing high-risk normal or pre-neoplastic tissue. We evaluated the following markers...

    Authors: Vijayalakshmi Ananthanarayanan, Ryan J Deaton, Ximing J Yang, Michael R Pins and Peter H Gann
    Citation: BMC Cancer 2006 6:73
    Content type: Research article Published on:

  41. Tumor burden can be pharmacologically controlled by inhibiting cell division and by direct, specific toxicity to the cancerous tissue. Unfortunately, tumors often develop intrinsic pharmacoresistance mediated ...

    Authors: Damir Janigro, Catalin Perju, Vincent Fazio, Kerri Hallene, Gabriele Dini, Mukesh K Agarwal and Luca Cucullo
    Citation: BMC Cancer 2006 6:72
    Content type: Research article Published on:

  42. The association between colorectal cancer (CRC) and smoking has not been consistent. Incomplete smoking history and association to a specific subset of CRC tumors have been proposed as explanations. The adenom...

    Authors: Mona Sæbø, Camilla F Skjelbred, Rebecca Breistein, Inger Marie B Lothe, Per Chr Hagen, Gunter Bock, Inger-Lise Hansteen and Elin H Kure
    Citation: BMC Cancer 2006 6:71
    Content type: Research article Published on:

  43. Cyclooxygenase-2 (COX-2) plays an important role in the development of lung cancer. DNA sequence variations in the COX-2 gene may lead to altered COX-2 production and/or activity, and so they cause inter-individu...

    Authors: Jung Min Park, Jin Eun Choi, Myung Hwa Chae, Won Kee Lee, Sung Ick Cha, Ji-Woong Son, Chang Ho Kim, Sin Kam, Young Mo Kang, Tae Hoon Jung and Jae Yong Park
    Citation: BMC Cancer 2006 6:70
    Content type: Research article Published on:

  44. Poorly differentiated midline carcinoma with a translocation between chromosomes 15 and 19, i.e. t(15;19), has been recognized as a distinct clinical entity for over a decade. This tumor affects young individu...

    Authors: Jens Engleson, Maria Soller, Ioannis Panagopoulos, Anna Dahlén, Michael Dictor and Mats Jerkeman
    Citation: BMC Cancer 2006 6:69
    Content type: Case report Published on:

  45. Isotope-coded affinity tag (ICAT) tandem mass spectrometry (MS) allows for qualitative and quantitative analysis of paired protein samples. We sought to determine whether ICAT technology could quantify and ide...

    Authors: Timothy M Pawlik, David H Hawke, Yanna Liu, Savitri Krishnamurthy, Herbert Fritsche, Kelly K Hunt and Henry M Kuerer
    Citation: BMC Cancer 2006 6:68
    Content type: Research article Published on:

  46. Genetic polymorphisms in DNA repair genes may influence individual variation in DNA repair capacity, which may be associated with risk of developing cancer. For colorectal cancer the importance of mutations in...

    Authors: Camilla Furu Skjelbred, Mona Sæbø, Håkan Wallin, Bjørn Andersen Nexø, Per Christian Hagen, Inger Marie Bowitz Lothe, Steinar Aase, Egil Johnson, Inger-Lise Hansteen, Ulla Vogel and Elin H Kure
    Citation: BMC Cancer 2006 6:67
    Content type: Research article Published on:

  47. HSVtk/ganciclovir (GCV) gene therapy has been extensively studied in tumors and relies largely on the gene expression of HSVtk. Most studies, however, have failed to demonstrate any significant benefit of a contr...

    Authors: LI Zi-Bo, ZENG Zhao-Jun, CHEN Qian, LUO Sai-Qun and HU Wei-Xin
    Citation: BMC Cancer 2006 6:66
    Content type: Research article Published on:

  49. Nitrogen-containing bisphosphonates (N-BPs) have been designed to inhibit osteoclast-mediated bone resorption. However, it is now accepted that part of their anti-tumor activities is related to interference wi...

    Authors: M Goffinet, M Thoulouzan, A Pradines, I Lajoie-Mazenc, Carolyn Weinbaum, JC Faye and S Séronie-Vivien
    Citation: BMC Cancer 2006 6:60
    Content type: Research article Published on:

  50. Previously, a total of five breast cancer subtypes have been identified based on variation in gene expression patterns. These expression profiles were also shown to be associated with different prognostic valu...

    Authors: Aslaug Aamodt Muggerud, Hilde Johnsen, Debra A Barnes, Adam Steel, Per Eystein Lønning, Bjørn Naume, Therese Sørlie and Anne-Lise Børresen-Dale
    Citation: BMC Cancer 2006 6:59
    Content type: Technical advance Published on:

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