Abstract
Background
Therapeutic use and effective function of recombinant urokinase (r-UK) for occluded ports need the presence of plasminogen.
Methods
As a therapeutic proof of principle, we demonstrate that the use of r-UK and autologous plasma effectively reestablishes the function of occluded central venous ports (CVP) resistant to routine management of catheter occlusion. Five patients with occluded ports resistant to the routine management were treated.
Results
All patients were successfully treated with thrombolytic therapy using intraluminal instillation of r-UK and autologous plasma.
Conclusion
Instillation of r-UK and autologous plasma is a safe and effective method for management of CVP occlusion.