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  1. This phase II study investigated efficacy and safety of weekly alternating Bevacizumab (BEV)/Irinotecan (CPT-11) or Oxaliplatin (OHP) associated to weekly 5-Fluorouracil (5-FU) in first line treatment of metas...

    Authors: Gemma Bruera, Alessandra Santomaggio, Katia Cannita, Paola Lanfiuti Baldi, Marianna Tudini, Federica De Galitiis, Maria Mancini, Paolo Marchetti, Adelmo Antonucci, Corrado Ficorella and Enrico Ricevuto
    Citation: BMC Cancer 2010 10:567
    Content type: Research article Published on:

  2. The effects of raloxifene, a novel selective estrogen receptor modulator, were studied in a mouse metastatic mammary cancer model expressing cytoplasmic ERα.

    Authors: Masa-Aki Shibata, Junji Morimoto, Eiko Shibata, Hitomi Kurose, Kanako Akamatsu, Zhong-Lian Li, Moriaki Kusakabe, Masahide Ohmichi and Yoshinori Otsuki
    Citation: BMC Cancer 2010 10:566
    Content type: Research article Published on:

  3. The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI)....

    Authors: Daniele Campa, Anika Hüsing, James D McKay, Olga Sinilnikova, Ulla Vogel, Anne Tjønneland, Kim Overvad, Jakob Stegger, Françoise Clavel-Chapelon, Nathalie Chabbert-Buffet, Guy Fagherazzi, Antonia Trichopoulou, Dimosthenis Zylis, Erifili Oustoglou, Sabine Rohrmann, Birgit Teucher…
    Citation: BMC Cancer 2010 10:563
    Content type: Research article Published on:

  4. The Ras association domain family 1 (RASSF1) gene is a Ras effector encoding two major mRNA forms, RASSF1A and RASSF1C, derived by alternative promoter selection and alternative mRNA splicing. RASSF1A is a tum...

    Authors: Mark E Reeves, Scott W Baldwin, Melissa L Baldwin, Shin-Tai Chen, Jeremy M Moretz, Robert J Aragon, Xinmin Li, Donna D Strong, Subburaman Mohan and Yousef G Amaar
    Citation: BMC Cancer 2010 10:562
    Content type: Research article Published on:

  5. Numerous studies reported genomic alterations in colorectal human tumors but few focused on rectal tumors with the specification of preoperative-treated or untreated tumors. The goals of this study were to lis...

    Authors: Benoît Romain, Agnès Neuville, Nicolas Meyer, Cécile Brigand, Serge Rohr, Anne Schneider, Marie-Pierre Gaub and Dominique Guenot
    Citation: BMC Cancer 2010 10:561
    Content type: Research article Published on:

  6. Targeted therapy approaches have been successfully introduced into the treatment of several cancers. The multikinase inhibitor Sorafenib has antitumor activity in solid tumors and its effects on acute lymphobl...

    Authors: Catrin Schult, Meike Dahlhaus, Sabine Ruck, Mandy Sawitzky, Francesca Amoroso, Sandra Lange, Daniela Etro, Aenne Glass, Georg Fuellen, Sonja Boldt, Olaf Wolkenhauer, Luca Maria Neri, Mathias Freund and Christian Junghanss
    Citation: BMC Cancer 2010 10:560
    Content type: Research article Published on:

  7. Gastrointestinal stromal tumors (GISTs) are common mesenchymal neoplasms in the gastrointestinal tract of humans and dogs. Little is known about the pathogenesis of these tumors. This study evaluated the role of

    Authors: Emmalena Gregory-Bryson, Elizabeth Bartlett, Matti Kiupel, Schantel Hayes and Vilma Yuzbasiyan-Gurkan
    Citation: BMC Cancer 2010 10:559
    Content type: Research article Published on:

  8. The main objective of this meta-analysis was to determine the clinical benefit of concurrent chemoradiotherapy (CCRT) compared with radiation alone (RT) in the treatment of nasopharyngeal carcinoma (NPC) patie...

    Authors: Li Zhang, Chong Zhao, Bijesh Ghimire, Ming-Huang Hong, Qing Liu, Yang Zhang, Ying Guo, Yi-Jun Huang and Zhong-Zhen Guan
    Citation: BMC Cancer 2010 10:558
    Content type: Research article Published on:

  9. Whether a systemic adjuvant treatment is needed is an area of controversy in patients with node-negative early breast cancer with tumor size of ≤1 cm, including T1mic.

    Authors: Ji Hyun Kwon, Yu Jung Kim, Keun-Wook Lee, Do-Youn Oh, So Yeon Park, Jee Hyun Kim, Eui Kyu Chie, Sung-Won Kim, Seock-Ah Im, In-Ah Kim, Tae-You Kim, In Ae Park, Dong-Young Noh, Yung-Jue Bang and Sung Whan Ha
    Citation: BMC Cancer 2010 10:557
    Content type: Research article Published on:

  10. Aberrant expression of HGF/SF and its receptor, c-Met, often correlates with advanced prostate cancer. Our previous study showed that expression of c-Met in prostate cancer cells was increased after attenuatio...

    Authors: William H Tu, Chunfang Zhu, Curtis Clark, James G Christensen and Zijie Sun
    Citation: BMC Cancer 2010 10:556
    Content type: Research article Published on:

  11. Polyamine metabolism has a critical role in cell death and proliferation representing a potential target for intervention in breast cancer (BC). This study investigates the expression of spermine oxidase (SMO)...

    Authors: Manuela Cervelli, Gabriella Bellavia, Emiliano Fratini, Roberto Amendola, Fabio Polticelli, Marco Barba, Rodolfo Federico, Fabrizio Signore, Giacomo Gucciardo, Rosalba Grillo, Patrick M Woster, Robert A Casero Jr and Paolo Mariottini
    Citation: BMC Cancer 2010 10:555
    Content type: Research article Published on:

  12. Many chemotherapeutic agents promote tumor cell death by activating the intrinsic pathway of apoptosis. Intrinsic apoptosis involves permeabilization of the mitochondrial outer membrane and the release of cyto...

    Authors: Sheila J Semaan and Robert W Nickells
    Citation: BMC Cancer 2010 10:554
    Content type: Research article Published on:

  13. Matrix metalloproteinases (MMPs) are involved in the degradation of protein components of the extracellular matrix and thus play an important role in tumor invasion and metastasis. Their expression is related ...

    Authors: Andrea Schröpfer, Ulrike Kammerer, Michaela Kapp, Johannes Dietl, Sonja Feix and Jelena Anacker
    Citation: BMC Cancer 2010 10:553
    Content type: Research article Published on:

  14. Fibronectin (FN) is known to be a large multifunction glycoprotein with binding sites for many substances, including N-terminal and C-terminal heparin-binding domains. We investigated the effects of highly pur...

    Authors: Nan-Hong Tang, Yan-Lin Chen, Xiao-Qian Wang, Xiu-Jin Li, Yong Wu, Qi-Lian Zou and Yuan-Zhong Chen
    Citation: BMC Cancer 2010 10:552
    Content type: Research article Published on:

  15. Cancer health disparities affecting low-income and minority patients are well documented. Root-causes are multifactorial, including diagnostic and treatment delays, social and financial barriers, and poor comm...

    Authors: Samantha Hendren, Jennifer J Griggs, Ronald M Epstein, Sharon Humiston, Sally Rousseau, Pascal Jean-Pierre, Jennifer Carroll, Amanat M Yosha, Starlene Loader and Kevin Fiscella
    Citation: BMC Cancer 2010 10:551
    Content type: Study protocol Published on:

  16. In the last years, the transmembrane proteoglycan NG2 has gained interest as a therapeutic target for the treatment of diverse tumor types, including gliomas, because increases of its expression correlate with...

    Authors: Marta Terrile, Irene Appolloni, Filippo Calzolari, Roberto Perris, Evelina Tutucci and Paolo Malatesta
    Citation: BMC Cancer 2010 10:550
    Content type: Research article Published on:

  17. Early metastasis and infiltration are survival limiting characteristics of pancreatic ductal adenocarcinoma (PDAC). Thus, PDAC is likely to harbor alterations in metastasis suppressor genes that may provide no...

    Authors: Wolf A Mardin, Kostadin O Petrov, Andreas Enns, Norbert Senninger, Joerg Haier and Soeren T Mees
    Citation: BMC Cancer 2010 10:549
    Content type: Research article Published on:

  18. Claudin-1 is a membrane protein of tight junctions, and is associated with the development of various cancers. However, the significance of claudin-1 expression in cancer cells is not well understood. Here, we...

    Authors: Harue Akasaka, Fuyuki Sato, Satoko Morohashi, Yunyan Wu, Yang Liu, Jun Kondo, Hiroki Odagiri, Kenichi Hakamada and Hiroshi Kijima
    Citation: BMC Cancer 2010 10:548
    Content type: Research article Published on:

  19. Correlation between circulating sex steroid levels and breast cancer has been controversial, with measurement of free, or bioavailable hormone rarely available. Salivary hormone levels represent the bioavailab...

    Authors: Constantine Dimitrakakis, David Zava, Spyros Marinopoulos, Alexandra Tsigginou, Aris Antsaklis and Rebecca Glaser
    Citation: BMC Cancer 2010 10:547
    Content type: Research article Published on:

  20. Local control in malignant salivary gland tumours is dose dependent. High local control rates in adenoid cystic carcinomas could be achieved by highly conformal radiotherapy techniques and particle (neutron/ca...

    Authors: Alexandra D Jensen, Anna Nikoghosyan, Christine Windemuth-Kieselbach, Jürgen Debus and Marc W Münter
    Citation: BMC Cancer 2010 10:546
    Content type: Study protocol Published on:

  21. About 50% of patients with colorectal cancer are destined to develop hepatic metastases. Radical resection is the most effective treatment for patients with colorectal liver metastases offering five year survi...

    Authors: Nikol Snoeren, Emile E Voest, Andre M Bergman, Otilia Dalesio, Henk M Verheul, Rob AEM Tollenaar, Joost RM van der Sijp, Sander B Schouten, Inne HM Borel Rinkes and R van Hillegersberg
    Citation: BMC Cancer 2010 10:545
    Content type: Study protocol Published on:

  22. Germline mutations in the DNA mismatch repair genes predispose to Lynch syndrome, thus conferring a high relative risk of colorectal and endometrial cancer. The MLH1, MSH2 and MSH6 mutational spectrum reported so...

    Authors: Georgia Thodi, Florentia Fostira, Raphael Sandaltzopoulos, George Nasioulas, Anastasios Grivas, Ioannis Boukovinas, Maria Mylonaki, Christos Panopoulos, Mirjana Brankovic Magic, George Fountzilas and Drakoulis Yannoukakos
    Citation: BMC Cancer 2010 10:544
    Content type: Research article Published on:

  23. New Zealand Māori have a poorer outcome from breast cancer than non-Māori, yet prognostic data are sparse. The objective of this study was to quantify levels of prognostic factors in a cohort of self-declared ...

    Authors: Gabi U Dachs, Maiko Kano, Ekaterina Volkova, Helen R Morrin, Valerie CL Davey, Gavin C Harris, Michelle Cheale, Christopher Frampton, Margaret J Currie, J Elisabeth Wells and Bridget A Robinson
    Citation: BMC Cancer 2010 10:543
    Content type: Research article Published on:

  24. MicroRNAs (miRNAs) play an important role in the regulation of cell growth, differentiation, apoptosis, and carcinogenesis. Detection of their expression may lead to identifying novel markers for breast cancer.

    Authors: Zheng-sheng Wu, Qiang Wu, Chao-qun Wang, Xiao-nan Wang, Yan Wang, Jing-jing Zhao, Shan-shan Mao, Gui-hong Zhang, Nong Zhang and Xiao-chun Xu
    Citation: BMC Cancer 2010 10:542
    Content type: Research article Published on:

  25. p27 is a cell cycle suppressor gene, whose protein is a negative regulator of cyclin/cdk complexes. p27 is also a potential target of retinoids in cancer prevention studies. In benign prostate hyperplasia (BPH...

    Authors: Winna Taylor, Amanda Mathias, Arshia Ali, Hengning Ke, Nikolay Stoynev, Anne Shilkaitis, Albert Green, Hiroaki Kiyokawa and Konstantin Christov
    Citation: BMC Cancer 2010 10:541
    Content type: Research article Published on:

  26. Activation of nuclear factor erythroid 2-related factor (Nrf2), which belongs to the basic leucine zipper transcription factor family, is a strategy for cancer chemopreventive phytochemicals. It is an importan...

    Authors: Lisa Becks, Misty Prince, Hannah Burson, Christopher Christophe, Mason Broadway, Ken Itoh, Masayuki Yamamoto, Michael Mathis, Elysse Orchard, Runhua Shi, Jerry McLarty, Kevin Pruitt, Songlin Zhang and Heather E Kleiner-Hancock
    Citation: BMC Cancer 2010 10:540
    Content type: Research article Published on:

  27. Around 20% of breast cancers (BC) show ERBB2 gene amplification and overexpression of the ERBB2 tyrosine kinase receptor. They are associated with a poor prognosis but can benefit from targeted therapy. A better ...

    Authors: Fabrice Sircoulomb, Ismahane Bekhouche, Pascal Finetti, José Adélaïde, Azza Ben Hamida, Julien Bonansea, Stéphane Raynaud, Charlène Innocenti, Emmanuelle Charafe-Jauffret, Carole Tarpin, Farhat Ben Ayed, Patrice Viens, Jocelyne Jacquemier, François Bertucci, Daniel Birnbaum and Max Chaffanet
    Citation: BMC Cancer 2010 10:539
    Content type: Research article Published on:

  28. LATS2, which encodes a novel serine/threonine kinase, is known to be important in centrosome duplication and in the maintenance of genomic stability. Recently, a potential role for LATS2 in cancer has been rep...

    Authors: Yan Zhang, Chun-Fang Hu, Jing Chen, Li-Xu Yan, Yi-Xin Zeng and Jian-Yong Shao
    Citation: BMC Cancer 2010 10:538
    Content type: Research article Published on:

  29. The significance of expression of different mucins in succession of malignant transformation of colorectal polyps is not determined yet. The aim of the present study was to determine the pattern of expression ...

    Authors: Mahsa Molaei, Babak Khoshkrood Mansoori, Reza Mashayekhi, Mohsen Vahedi, Mohamad Amin Pourhoseingholi, Seyed Reza Fatemi and Mohammad Reza Zali
    Citation: BMC Cancer 2010 10:537
    Content type: Research article Published on:

  30. The mammalian target of rapamycin (mTOR) plays a key role in cellular growth and homeostasis. The purpose of our present study is to investigate the expression of activated mTOR (p-mTOR) in gastric cancer pati...

    Authors: Da-zhi Xu, Qi-rong Geng, Ying Tian, Mu-yan Cai, Xin-juan Fang, You-qing Zhan, Zhi-wei Zhou, Wei Li, Ying-bo Chen, Xiao-wei Sun, Yuan-xiang Guan, Yuan-fang Li and Tong-yu Lin
    Citation: BMC Cancer 2010 10:536
    Content type: Research article Published on:

  31. Locally advanced (pT3-4N0M0) hepatocellular carcinoma (HCC) is a heterogeneous group of tumors, which consists of four different categories, including HCC with "multiple tumors more than 5 cm", "major vascular...

    Authors: Binkui Li, Yunfei Yuan, Guihua Chen, Liru He, Yaqi Zhang, Jinqing Li, Guohui Li and Wan Yee Lau
    Citation: BMC Cancer 2010 10:535
    Content type: Research article Published on:

  32. Accurate evaluation of human epidermal growth factor receptor type-2 (HER2) status based on core needle biopsy (CNB) specimens is mandatory for identification of patients with primary breast cancer who will be...

    Authors: Hitoshi Tsuda, Masafumi Kurosumi, Shinobu Umemura, Sohei Yamamoto, Takayuki Kobayashi and Robert Yoshiyuki Osamura
    Citation: BMC Cancer 2010 10:534
    Content type: Research article Published on:

  33. Treatment of patients with recurrent glioma includes neurosurgical resection, chemotherapy, or radiation therapy. In most cases, a full course of radiotherapy has been applied after primary diagnosis, therefor...

    Authors: Stephanie E Combs, Iris Burkholder, Lutz Edler, Stefan Rieken, Daniel Habermehl, Oliver Jäkel, Thomas Haberer, Renate Haselmann, Andreas Unterberg, Wolfgang Wick and Jürgen Debus
    Citation: BMC Cancer 2010 10:533
    Content type: Study protocol Published on:

  34. Genome wide gene expression data is a rich source for the identification of gene signatures suitable for clinical purposes and a number of statistical algorithms have been described for both identification and...

    Authors: Martin Lauss, Attila Frigyesi, Tobias Ryden and Mattias Höglund
    Citation: BMC Cancer 2010 10:532
    Content type: Software Published on:

  35. The Exercise Intensity Trial (EXcITe) is a randomized trial to compare the efficacy of supervised moderate-intensity aerobic training to moderate to high-intensity aerobic training, relative to attention contr...

    Authors: Lee W Jones, Pamela S Douglas, Neil D Eves, P Kelly Marcom, William E Kraus, James E Herndon II, Brant A Inman, Jason D Allen and Jeffrey Peppercorn
    Citation: BMC Cancer 2010 10:531
    Content type: Study protocol Published on:

  37. YN968D1 (Apatinib) selectively inhibits phosphorylation of VEGFR-2 and tumor angiogenesis in mice model. The study was conducted to determine the maximum tolerated dose (MTD), safety profile, pharmacokinetic v...

    Authors: Jin Li, Xinmin Zhao, Lei Chen, Haiyi Guo, Fangfang Lv, Ka Jia, Ke Yv, Fengqing Wang, Chuan Li, Jun Qian, Chunlei Zheng and Yunxia Zuo
    Citation: BMC Cancer 2010 10:529
    Content type: Research article Published on:

  38. Controversy exists with regard to the impact that the different components of diagnosis delay may have on the degree of invasion and prognosis in patients with colorectal cancer. The follow-up strategies after...

    Authors: Salvador Pita Fernández, Sonia Pértega Díaz, Beatriz López Calviño, Paloma González Santamaría, Teresa Seoane Pillado, Francisco Arnal Monreal, Francesc Maciá, María Antonia Sánchez Calavera, Alejandro Espí Macías, Manuel Valladares Ayerbes, Alejandro Pazos, Margarita Reboredo López, Luis González Saez, María Ramos Montserrat, Josep María Segura Noguera, Isabel Monreal Aliaga…
    Citation: BMC Cancer 2010 10:528
    Content type: Study protocol Published on:

  39. We analyzed the responses to first line treatment and clinical outcomes of metastatic breast cancer patients treated with palliative doxorubicin/cyclophosphamide (AC) according to molecular cancer subtype.

    Authors: Seong Yoon Yi, Jin Seok Ahn, Ji Eun Uhm, Do Hyoung Lim, Sang Hoon Ji, Hyun Jung Jun, Kyoung Ha Kim, Myung Hee Chang, Min Jae Park, Eun Yoon Cho, Yoon La Choi, Yeon Hee Park and Young-Hyuck Im
    Citation: BMC Cancer 2010 10:527
    Content type: Research article Published on:

  40. Glycogen Synthase Kinase-3 (GSK-3) α and β are two serine-threonine kinases controlling insulin, Wnt/β-catenin, NF-κB signaling and other cancer-associated transduction pathways. Recent evidence suggests that ...

    Authors: Francesco Piazza, Sabrina Manni, Laura Quotti Tubi, Barbara Montini, Laura Pavan, Anna Colpo, Marianna Gnoato, Anna Cabrelle, Fausto Adami, Renato Zambello, Livio Trentin, Carmela Gurrieri and Gianpietro Semenzato
    Citation: BMC Cancer 2010 10:526
    Content type: Research article Published on:

  41. Association between rectal or colon cancer risk and serine hydroxymethyltransferase 1 (SHMT1) C1420T or methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms was assessed. The serum total homocysteine (...

    Authors: Viktor Komlósi, Erika Hitre, Éva Pap, Vilmos Adleff, Andrea Réti, Éva Székely, Anna Bíró, Péter Rudnai, Bernadette Schoket, Judit Müller, Béla Tóth, Szabolcs Ottó, Miklós Kásler, Judit Kralovánszky and Barna Budai
    Citation: BMC Cancer 2010 10:525
    Content type: Research article Published on:

  42. The enhancer of zeste homolog 2 (EZH2) gene exerts oncogene-like activities and its (over)expression has been linked to several human malignancies. Here, we studied a possible association between EZH2 expression ...

    Authors: Nina Wagener, Stephan Macher-Goeppinger, Maria Pritsch, Johannes Hüsing, Karin Hoppe-Seyler, Peter Schirmacher, Jesco Pfitzenmaier, Axel Haferkamp, Felix Hoppe-Seyler and Markus Hohenfellner
    Citation: BMC Cancer 2010 10:524
    Content type: Research article Published on:

  43. Genetic factors related to the regulation of apoptosis in schizophrenia patients may be involved in a reduced vulnerability to cancer. XRCC4 is one of the potential candidate genes associated with schizophreni...

    Authors: Yang Wang, Lei Wang, Xingwang Li, Baocheng Liu, Qingzhu Zhao, Peng Chen, Ti Wang, Tao Li, Jue Ji, Fengping Yang, Quan Wang, Jinfen Wang, Yanzeng Xiao, Yifeng Xu, Guoyin Feng, Zhihai Peng…
    Citation: BMC Cancer 2010 10:523
    Content type: Research article Published on:

  44. As a key gene in the immunosurveillance of cell malignancy, Cytotoxic T-lymphocyte antigen 4 (CTLA-4 is an important negative regulator of T cell activation and proliferation. The CTLA-4 +49G > A polymorphism ...

    Authors: Jian Zheng, Xiao Yu, Lan Jiang, Mang Xiao, Bing Bai, Jiachun Lu and Yifeng Zhou
    Citation: BMC Cancer 2010 10:522
    Content type: Research article Published on:

  45. cis-urocanic acid (cis-UCA) is an endogenous amino acid metabolite capable of transporting protons from the mildly acidic extracellular medium into the cell cytosol. The resulting intracellular acidification s...

    Authors: Emilia Peuhu, Aura Kaunisto, Jarmo K Laihia, Lasse Leino and John E Eriksson
    Citation: BMC Cancer 2010 10:521
    Content type: Research article Published on:

  46. Radiation induced optic neuropathy (RION) is a rare but severe consequence of radiation therapy that is associated with adjuvant chemotherapy, specifically therapy with vincristine or nitrosoureas. However, th...

    Authors: Stefanie Schreiber, Vanessa Prox-Vagedes, Erck Elolf, Ines Brueggemann, Guenther Gademann, Imke Galazky and Claudius Bartels
    Citation: BMC Cancer 2010 10:520
    Content type: Case report Published on:

  47. The goal of this prospective study was to determine (a) concentrations of the carbohydrate biomarkers Thomsen Friedenreich (TF) antigen and its precursor, Tn antigen, in nipple discharge (ND) collected from wo...

    Authors: Susan L Deutscher, Marie Dickerson, Gerald Gui, Jessica Newton, Jeffrey E Holm, Nancy Vogeltanz-Holm, Beth Kliethermes, John E Hewett, Senthil R Kumar, Thomas P Quinn and Edward R Sauter
    Citation: BMC Cancer 2010 10:519
    Content type: Research article Published on:

  48. Abnormalities of 11q23 involving the MLL gene are found in approximately 10% of human leukemias. To date, nearly 100 different chromosome bands have been described in rearrangements involving 11q23 and 64 fusion ...

    Authors: Nuno Cerveira, Claus Meyer, Joana Santos, Lurdes Torres, Susana Lisboa, Manuela Pinheiro, Susana Bizarro, Cecília Correia, Lucília Norton, Rolf Marschalek and Manuel R Teixeira
    Citation: BMC Cancer 2010 10:518
    Content type: Research article Published on:

  49. Epigenetic inactivation of tumor suppressor genes (TSG) by promoter CpG island hypermethylation is a hallmark of cancer. To assay its extent in human lymphoma, methylation of 24 TSG was analyzed in lymphoma-de...

    Authors: Sonja Eberth, Björn Schneider, Andreas Rosenwald, Elena M Hartmann, Julia Romani, Margarete Zaborski, Reiner Siebert, Hans G Drexler and Hilmar Quentmeier
    Citation: BMC Cancer 2010 10:517
    Content type: Research article Published on:

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