Gill JK, Wilkens LR, Pollak MN, Stanczyk FZ, Kolonel LN: Androgens, growth factors, and risk of prostate cancer: the Multiethnic Cohort. Prostate. 2010, 70 (8): 906-915.
CAS
PubMed
PubMed Central
Google Scholar
Alberti C: Hereditary/familial versus sporadic prostate cancer: few indisputable genetic differences and many similar clinicopathological features. Eur Rev Med Pharmacol Sci. 2010, 14 (1): 31-41.
CAS
PubMed
Google Scholar
Marlow NM, Halpern MT, Pavluck AL, Ward EM, Chen AY: Disparities associated with advanced prostate cancer stage at diagnosis. J Health Care Poor Underserved. 2010, 21 (1): 112-131. 10.1353/hpu.0.0253.
Article
PubMed
Google Scholar
Yang RM, Naitoh J, Murphy M, Wang HJ, Phillipson J, deKernion JB, Loda M, Reiter RE: Low p27 expression predicts poor disease-free survival in patients with prostate cancer. J Urol. 1998, 159 (3): 941-945. 10.1016/S0022-5347(01)63776-5.
Article
CAS
PubMed
Google Scholar
Roy S, Gu M, Ramasamy K, Singh RP, Agarwal C, Siriwardana S, Sclafani RA, Agarwal R: p21/Cip1 and p27/Kip1 Are essential molecular targets of inositol hexaphosphate for its antitumor efficacy against prostate cancer. Cancer Res. 2009, 69 (3): 1166-1173. 10.1158/0008-5472.CAN-08-3115.
Article
CAS
PubMed
PubMed Central
Google Scholar
Macri E, Loda M: Role of p27 in prostate carcinogenesis. Cancer Metastasis Rev. 1998, 17 (4): 337-344. 10.1023/A:1006133620914.
Article
CAS
PubMed
Google Scholar
Cordon-Cardo C, Koff A, Drobnjak M, Capodieci P, Osman I, Millard SS, Gaudin PB, Fazzari M, Zhang ZF, Massague J, et al: Distinct altered patterns of p27KIP1 gene expression in benign prostatic hyperplasia and prostatic carcinoma. J Natl Cancer Inst. 1998, 90 (17): 1284-1291. 10.1093/jnci/90.17.1284.
Article
CAS
PubMed
Google Scholar
Toyoshima H, Hunter T: p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell. 1994, 78 (1): 67-74. 10.1016/0092-8674(94)90573-8.
Article
CAS
PubMed
Google Scholar
Sgambato A, Cittadini A, Faraglia B, Weinstein IB: Multiple functions of p27(Kip1) and its alterations in tumor cells: a review. J Cell Physiol. 2000, 183 (1): 18-27. 10.1002/(SICI)1097-4652(200004)183:1<18::AID-JCP3>3.0.CO;2-S.
Article
CAS
PubMed
Google Scholar
Majumder PK, Grisanzio C, O'Connell F, Barry M, Brito JM, Xu Q, Guney I, Berger R, Herman P, Bikoff R, et al: A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression. Cancer Cell. 2008, 14 (2): 146-155. 10.1016/j.ccr.2008.06.002.
Article
CAS
PubMed
PubMed Central
Google Scholar
Roy S, Kaur M, Agarwal C, Tecklenburg M, Sclafani RA, Agarwal R: p21 and p27 induction by silibinin is essential for its cell cycle arrest effect in prostate carcinoma cells. Mol Cancer Ther. 2007, 6 (10): 2696-2707. 10.1158/1535-7163.MCT-07-0104.
Article
CAS
PubMed
Google Scholar
Cuadrado M, Gutierrez-Martinez P, Swat A, Nebreda AR, Fernandez-Capetillo O: p27Kip1 stabilization is essential for the maintenance of cell cycle arrest in response to DNA damage. Cancer Res. 2009, 69 (22): 8726-8732. 10.1158/0008-5472.CAN-09-0729.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shaffer DR, Viale A, Ishiwata R, Leversha M, Olgac S, Manova K, Satagopan J, Scher H, Koff A: Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate. Proc Natl Acad Sci USA. 2005, 102 (1): 210-215. 10.1073/pnas.0407362102.
Article
CAS
PubMed
Google Scholar
Hu L, Ibrahim S, Liu C, Skaar J, Pagano M, Karpatkin S: Thrombin induces tumor cell cycle activation and spontaneous growth by down-regulation of p27Kip1, in association with the up-regulation of Skp2 and MiR-222. Cancer Res. 2009, 69 (8): 3374-3381. 10.1158/0008-5472.CAN-08-4290.
Article
CAS
PubMed
PubMed Central
Google Scholar
Di Cristofano A, De Acetis M, Koff A, Cordon-Cardo C, Pandolfi PP: Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse. Nat Genet. 2001, 27 (2): 222-224. 10.1038/84879.
Article
CAS
PubMed
Google Scholar
Kwabi-Addo B, Giri D, Schmidt K, Podsypanina K, Parsons R, Greenberg N, Ittmann M: Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression. Proc Natl Acad Sci USA. 2001, 98 (20): 11563-11568. 10.1073/pnas.201167798.
Article
CAS
PubMed
PubMed Central
Google Scholar
Trotman LC, Niki M, Dotan ZA, Koutcher JA, Di Cristofano A, Xiao A, Khoo AS, Roy-Burman P, Greenberg NM, Van Dyke T, et al: Pten dose dictates cancer progression in the prostate. PLoS Biol. 2003, 1 (3): E59.-10.1371/journal.pbio.0000059.
Article
PubMed
PubMed Central
Google Scholar
Besson A: [p27Kip1: tumor suppressor and oncogene?]. Med Sci (Paris). 2007, 23 (12): 1089-1091.
Article
Google Scholar
Fero ML, Randel E, Gurley KE, Roberts JM, Kemp CJ: The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature. 1998, 396 (6707): 177-180. 10.1038/24179.
Article
CAS
PubMed
Google Scholar
Philipp-Staheli J, Payne SR, Kemp CJ: p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer. Exp Cell Res. 2001, 264 (1): 148-168. 10.1006/excr.2000.5143.
Article
CAS
PubMed
Google Scholar
Vis AN, Noordzij MA, Fitoz K, Wildhagen MF, Schroder FH, van der Kwast TH: Prognostic value of cell cycle proteins p27(kip1) and MIB-1, and the cell adhesion protein CD44 s in surgically treated patients with prostate cancer. J Urol. 2000, 164 (6): 2156-2161. 10.1016/S0022-5347(05)66989-3.
Article
CAS
PubMed
Google Scholar
Lotan R: Retinoids in cancer chemoprevention. Faseb J. 1996, 10 (9): 1031-1039.
CAS
PubMed
Google Scholar
McCormick DL, Rao KV, Steele VE, Lubet RA, Kelloff GJ, Bosland MC: Chemoprevention of rat prostate carcinogenesis by 9-cis-retinoic acid. Cancer Res. 1999, 59 (3): 521-524.
CAS
PubMed
Google Scholar
Christov KT, Moon RC, Lantvit DD, Boone CW, Steele VE, Lubet RA, Kelloff GJ, Pezzuto JM: 9-cis-retinoic acid but not 4-(hydroxyphenyl)retinamide inhibits prostate intraepithelial neoplasia in Noble rats. Cancer Res. 2002, 62 (18): 5178-5182.
CAS
PubMed
Google Scholar
Touma SE, Perner S, Rubin MA, Nanus DM, Gudas LJ: Retinoid metabolism and ALDH1A2 (RALDH2) expression are altered in the transgenic adenocarcinoma mouse prostate model. Biochem Pharmacol. 2009, 78 (9): 1127-1138. 10.1016/j.bcp.2009.06.022.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gudas LJ, Sporn MB, Roberts AB: Cellular biology and biochemistry of retinoids. The Retinoids: Biology, Chemistry, and Medicine. Edited by: Sporn M, Roberts A, Goodman D. 1994, New York: Raven Press
Google Scholar
Hail N, Chen P, Kepa JJ: Selective apoptosis induction by the cancer chemopreventive agent N-(4-hydroxyphenyl)retinamide is achieved by modulating mitochondrial bioenergetics in premalignant and malignant human prostate epithelial cells. Apoptosis. 2009, 14 (7): 849-863. 10.1007/s10495-009-0356-4.
Article
CAS
PubMed
PubMed Central
Google Scholar
Teixeira LT, Kiyokawa H, Peng XD, Christov KT, Frohman LA, Kineman RD: p27Kip1-deficient mice exhibit accelerated growth hormone-releasing hormone (GHRH)-induced somatotrope proliferation and adenoma formation. Oncogene. 2000, 19 (15): 1875-1884. 10.1038/sj.onc.1203490.
Article
CAS
PubMed
Google Scholar
Christov KT, Moon RC, Lantvit DD, Boone CW, Kelloff GJ, Steele VE, Lubet RA, Pezzuto JM: Prostate intraepithelial neoplasia in Noble rats, a potential intermediate endpoint for chemoprevention studies. Eur J Cancer. 2004, 40 (9): 1404-1411. 10.1016/j.ejca.2003.11.037.
Article
CAS
PubMed
Google Scholar
Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O, et al: A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA. 1995, 92 (20): 9363-9367. 10.1073/pnas.92.20.9363.
Article
CAS
PubMed
PubMed Central
Google Scholar
Shilkaitis A, Green A, Punj V, Steele V, Lubet R, Christov K: Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53-independent mechanism. Breast Cancer Res. 2005, 7 (6): R1132-1140. 10.1186/bcr1350.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fero ML, Rivkin M, Tasch M, Porter P, Carow CE, Firpo E, Polyak K, Tsai LH, Broudy V, Perlmutter RM, et al: A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell. 1996, 85 (5): 733-744. 10.1016/S0092-8674(00)81239-8.
Article
CAS
PubMed
Google Scholar
Kiyokawa H, Kineman RD, Manova-Todorova KO, Soares VC, Hoffman ES, Ono M, Khanam D, Hayday AC, Frohman LA, Koff A: Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1). Cell. 1996, 85 (5): 721-732. 10.1016/S0092-8674(00)81238-6.
Article
CAS
PubMed
Google Scholar
Nakayama K, Ishida N, Shirane M, Inomata A, Inoue T, Shishido N, Horii I, Loh DY: Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell. 1996, 85 (5): 707-720. 10.1016/S0092-8674(00)81237-4.
Article
CAS
PubMed
Google Scholar
Leav I, Merk FB, Kwan PW, Ho SM: Androgen-supported estrogen-enhanced epithelial proliferation in the prostates of intact Noble rats. Prostate. 1989, 15 (1): 23-40. 10.1002/pros.2990150104.
Article
CAS
PubMed
Google Scholar
Neuhouser ML, Barnett MJ, Kristal AR, Ambrosone CB, King IB, Thornquist M, Goodman GG: Dietary supplement use and prostate cancer risk in the Carotene and Retinol Efficacy Trial. Cancer Epidemiol Biomarkers Prev. 2009, 18 (8): 2202-2206. 10.1158/1055-9965.EPI-09-0013.
Article
CAS
PubMed
PubMed Central
Google Scholar
Watters JL, Gail MH, Weinstein SJ, Virtamo J, Albanes D: Associations between alpha-tocopherol, beta-carotene, and retinol and prostate cancer survival. Cancer Res. 2009, 69 (9): 3833-3841. 10.1158/0008-5472.CAN-08-4640.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen W, Yan C, Hou J, Pu J, Ouyang J, Wen D: ATRA enhances bystander effect of suicide gene therapy in the treatment of prostate cancer. Urol Oncol. 2008, 26 (4): 397-405.
Article
CAS
PubMed
Google Scholar
Huynh CK, Brodie AM, Njar VC: Inhibitory effects of retinoic acid metabolism blocking agents (RAMBAs) on the growth of human prostate cancer cells and LNCaP prostate tumour xenografts in SCID mice. Br J Cancer. 2006, 94 (4): 513-523. 10.1038/sj.bjc.6602971.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tokar EJ, Ancrile BB, Ablin RJ, Webber MM: Cholecalciferol (vitamin D3) and the retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) are synergistic for chemoprevention of prostate cancer. J Exp Ther Oncol. 2006, 5 (4): 323-333.
CAS
PubMed
Google Scholar
Alimonti A, Nardella C, Chen Z, Clohessy JG, Carracedo A, Trotman LC, Cheng K, Varmeh S, Kozma SC, Thomas G, et al: A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. J Clin Invest. 2010, 120 (3): 681-693. 10.1172/JCI40535.
Article
CAS
PubMed
PubMed Central
Google Scholar