Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ: Cancer statistics, 2009. CA Cancer J Clin. 2009, 59 (4): 225-249. 10.3322/caac.20006.
Article
PubMed
Google Scholar
Armstrong AJ, Garrett-Mayer ES, Yang YC, de Wit R, Tannock IF, Eisenberger M: A contemporary prognostic nomogram for men with hormone-refractory metastatic prostate cancer: a TAX327 study analysis. Clin Cancer Res. 2007, 13 (21): 6396-6403. 10.1158/1078-0432.CCR-07-1036.
Article
CAS
PubMed
Google Scholar
Balk SP: Androgen receptor as a target in androgen-independent prostate cancer. Urology. 2002, 60 (3 Suppl 1): 132-138. 10.1016/S0090-4295(02)01593-5. discussion 138-139
Article
PubMed
Google Scholar
Gelmann EP: Molecular biology of the androgen receptor. J Clin Oncol. 2002, 20 (13): 3001-3015. 10.1200/JCO.2002.10.018.
Article
CAS
PubMed
Google Scholar
So A, Gleave M, Hurtado-Col A, Nelson C: Mechanisms of the development of androgen independence in prostate cancer. World J Urol. 2005, 23 (1): 1-9. 10.1007/s00345-004-0473-1.
Article
CAS
PubMed
Google Scholar
Bottaro DP, Rubin JS, Faletto DL, Chan AM, Kmiecik TE, Vande Woude GF, Aaronson SA: Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science. 1991, 251 (4995): 802-804. 10.1126/science.1846706.
Article
CAS
PubMed
Google Scholar
Knudsen BS, Edlund M: Prostate cancer and the met hepatocyte growth factor receptor. Adv Cancer Res. 2004, 91: 31-67. full_text.
Article
CAS
PubMed
Google Scholar
Humphrey PA, Zhu X, Zarnegar R, Swanson PE, Ratliff TL, Vollmer RT, Day ML: Hepatocyte growth factor and its receptor (c-MET) in prostatic carcinoma. Am J Pathol. 1995, 147 (2): 386-396.
CAS
PubMed
PubMed Central
Google Scholar
Kasai S, Sugimura K, Matsumoto K, Nishi N, Kishimoto T, Nakamura T: Hepatocyte growth factor is a paracrine regulator of rat prostate epithelial growth. Biochem Biophys Res Commun. 1996, 228 (2): 646-652. 10.1006/bbrc.1996.1710.
Article
CAS
PubMed
Google Scholar
Knudsen BS, Gmyrek GA, Inra J, Scherr DS, Vaughan ED, Nanus DM, Kattan MW, Gerald WL, Vande Woude GF: High expression of the Met receptor in prostate cancer metastasis to bone. Urology. 2002, 60 (6): 1113-1117. 10.1016/S0090-4295(02)01954-4.
Article
PubMed
Google Scholar
Verras M, Lee J, Xue H, Li TH, Wang Y, Sun Z: The androgen receptor negatively regulates the expression of c-Met: implications for a novel mechanism of prostate cancer progression. Cancer Res. 2007, 67 (3): 967-975. 10.1158/0008-5472.CAN-06-3552.
Article
CAS
PubMed
Google Scholar
Christensen JG, Schreck R, Burrows J, Kuruganti P, Chan E, Le P, Chen J, Wang X, Ruslim L, Blake R, et al: A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo. Cancer Res. 2003, 63 (21): 7345-7355.
CAS
PubMed
Google Scholar
Smolen GA, Sordella R, Muir B, Mohapatra G, Barmettler A, Archibald H, Kim WJ, Okimoto RA, Bell DW, Sgroi DC, et al: Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752. Proc Natl Acad Sci USA. 2006, 103 (7): 2316-2321. 10.1073/pnas.0508776103.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zou HY, Li Q, Lee JH, Arango ME, McDonnell SR, Yamazaki S, Koudriakova TB, Alton G, Cui JJ, Kung PP, et al: An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res. 2007, 67 (9): 4408-4417. 10.1158/0008-5472.CAN-06-4443.
Article
CAS
PubMed
Google Scholar
Christensen JG, Zou HY, Arango ME, Li Q, Lee JH, McDonnell SR, Yamazaki S, Alton GR, Mroczkowski B, Los G: Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma. Mol Cancer Ther. 2007, 6 (12 Pt 1): 3314-3322. 10.1158/1535-7163.MCT-07-0365.
Article
CAS
PubMed
Google Scholar
Yang Y, Wislez M, Fujimoto N, Prudkin L, Izzo JG, Uno F, Ji L, Hanna AE, Langley RR, Liu D, et al: A selective small molecule inhibitor of c-Met, PHA-665752, reverses lung premalignancy induced by mutant K-ras. Mol Cancer Ther. 2008, 7 (4): 952-960. 10.1158/1535-7163.MCT-07-2045.
Article
CAS
PubMed
PubMed Central
Google Scholar
Klein KA, Reiter RE, Redula J, Moradi H, Zhu XL, Brothman AR, Lamb DJ, Marcelli M, Belldegrun A, Witte ON, et al: Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice. Nat Med. 1997, 3 (4): 402-408. 10.1038/nm0497-402.
Article
CAS
PubMed
Google Scholar
Thalmann GN, Anezinis PE, Chang SM, Zhau HE, Kim EE, Hopwood VL, Pathak S, von Eschenbach AC, Chung LW: Androgen-independent cancer progression and bone metastasis in the LNCaP model of human prostate cancer. Cancer Res. 1994, 54 (10): 2577-2581.
CAS
PubMed
Google Scholar
Tepper CG, Boucher DL, Ryan PE, Ma AH, Xia L, Lee LF, Pretlow TG, Kung HJ: Characterization of a novel androgen receptor mutation in a relapsed CWR22 prostate cancer xenograft and cell line. Cancer Res. 2002, 62 (22): 6606-6614.
CAS
PubMed
Google Scholar
Adam RM, Orsola A, Freeman MR: A novel method for implantation of LNCaP prostate tumor cells under the renal capsule. In Vitro Cell Dev Biol Anim. 2001, 37 (6): 360-362.
Article
CAS
PubMed
Google Scholar
Wang Y, Xue H, Cutz JC, Bayani J, Mawji NR, Chen WG, Goetz LJ, Hayward SW, Sadar MD, Gilks CB, et al: An orthotopic metastatic prostate cancer model in SCID mice via grafting of a transplantable human prostate tumor line. Lab Invest. 2005, 85 (11): 1392-1404. 10.1038/labinvest.3700335.
Article
PubMed
Google Scholar
Gleave ME, Hsieh JT, Wu HC, von Eschenbach AC, Chung LW: Serum prostate specific antigen levels in mice bearing human prostate LNCaP tumors are determined by tumor volume and endocrine and growth factors. Cancer Res. 1992, 52 (6): 1598-1605.
CAS
PubMed
Google Scholar
Sato N, Gleave ME, Bruchovsky N, Rennie PS, Beraldi E, Sullivan LD: A metastatic and androgen-sensitive human prostate cancer model using intraprostatic inoculation of LNCaP cells in SCID mice. Cancer Res. 1997, 57 (8): 1584-1589.
CAS
PubMed
Google Scholar
Stephenson RA, Dinney CP, Gohji K, Ordonez NG, Killion JJ, Fidler IJ: Metastatic model for human prostate cancer using orthotopic implantation in nude mice. J Natl Cancer Inst. 1992, 84 (12): 951-957. 10.1093/jnci/84.12.951.
Article
CAS
PubMed
Google Scholar
Rembrink K, Romijn JC, van der Kwast TH, Rubben H, Schroder FH: Orthotopic implantation of human prostate cancer cell lines: a clinically relevant animal model for metastatic prostate cancer. Prostate. 1997, 31 (3): 168-174. 10.1002/(SICI)1097-0045(19970515)31:3<168::AID-PROS4>3.0.CO;2-H.
Article
CAS
PubMed
Google Scholar
Kim SJ, Johnson M, Koterba K, Herynk MH, Uehara H, Gallick GE: Reduced c-met expression by an adenovirus expressing a c-met ribozyme inhibits tumorigenic growth and lymph node metastases of PC3-LN4 prostate tumor cells in an orthotopic nude mouse model. Cancer Res. 2003, 9 (14): 5161-5170.
CAS
Google Scholar
Chen CD, Welsbie DS, Tran C, Baek SH, Chen R, Vessella R, Rosenfeld MG, Sawyers CL: Molecular determinants of resistance to antiandrogen therapy. Nat Med. 2004, 10 (1): 33-39. 10.1038/nm972.
Article
PubMed
Google Scholar
Mostaghel EA, Page ST, Lin DW, Fazli L, Coleman IM, True LD, Knudsen B, Hess DL, Nelson CC, Matsumoto AM, et al: Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer. Cancer Res. 2007, 67 (10): 5033-5041. 10.1158/0008-5472.CAN-06-3332.
Article
CAS
PubMed
Google Scholar
Huggins C, Hodges CV: Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. 1941. J Urol. 2002, 168 (1): 9-12. 10.1016/S0022-5347(05)64820-3.
Article
PubMed
Google Scholar
Curtin D, Jenkins S, Farmer N, Anderson AC, Haisenleder DJ, Rissman E, Wilson EM, Shupnik MA: Androgen suppression of GnRH-stimulated rat LHbeta gene transcription occurs through Sp1 sites in the distal GnRH-responsive promoter region. Mol Endocrinol. 2001, 15 (11): 1906-1917. 10.1210/me.15.11.1906.
CAS
PubMed
Google Scholar
Maeda A, Nakashiro K, Hara S, Sasaki T, Miwa Y, Tanji N, Yokoyama M, Hamakawa H, Oyasu R: Inactivation of AR activates HGF/c-Met system in human prostatic carcinoma cells. Biochem Biophy Res Commun. 2006, 347 (4): 1158-1165. 10.1016/j.bbrc.2006.07.040.
Article
CAS
Google Scholar
Nakashiro K, Hara S, Shinohara Y, Oyasu M, Kawamata H, Shintani S, Hamakawa H, Oyasu R: Phenotypic switch from paracrine to autocrine role of hepatocyte growth factor in an androgen-independent human prostatic carcinoma cell line, CWR22R. Am J Pathol. 2004, 165 (2): 533-540.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tate A, Isotani S, Bradley MJ, Sikes RA, Davis R, Chung LW, Edlund M: Met-Independent Hepatocyte Growth Factor-mediated regulation of cell adhesion in human prostate cancer cells. BMC Cancer. 2006, 6: 197-10.1186/1471-2407-6-197.
Article
PubMed
PubMed Central
Google Scholar
Agoulnik IU, Vaid A, Bingman WE, Erdeme H, Frolov A, Smith CL, Ayala G, Ittmann MM, Weigel NL: Role of SRC-1 in the promotion of prostate cancer cell growth and tumor progression. Cancer Res. 2005, 65 (17): 7959-7967.
CAS
PubMed
Google Scholar
Craft N, Shostak Y, Carey M, Sawyers CL: A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase. Nat Med. 1999, 5 (3): 280-285. 10.1038/6495.
Article
CAS
PubMed
Google Scholar
Kosharskyy B, Solban N, Chang SK, Rizvi I, Chang Y, Hasan T: A mechanism-based combination therapy reduces local tumor growth and metastasis in an orthotopic model of prostate cancer. Cancer Res. 2006, 66 (22): 10953-10958. 10.1158/0008-5472.CAN-06-1793.
Article
CAS
PubMed
Google Scholar
Solban N, Selbo PK, Sinha AK, Chang SK, Hasan T: Mechanistic investigation and implications of photodynamic therapy induction of vascular endothelial growth factor in prostate cancer. Cancer Res. 2006, 66 (11): 5633-5640. 10.1158/0008-5472.CAN-06-0604.
Article
CAS
PubMed
Google Scholar
Scatena CD, Hepner MA, Oei YA, Dusich JM, Yu SF, Purchio T, Contag PR, Jenkins DE: Imaging of bioluminescent LNCaP-luc-M6 tumors: a new animal model for the study of metastatic human prostate cancer. Prostate. 2004, 59 (3): 292-303. 10.1002/pros.20003.
Article
CAS
PubMed
Google Scholar
Munshi N, Jeay S, Li Y, Chen CR, France DS, Ashwell MA, Hill J, Moussa MM, Leggett DS, Li CJ: ARQ 197, a novel and selective inhibitor of the human c-met receptor tyrosine kinase with antitumor activity. Mol Cancer Ther. 2010, 9 (6): 1544-1553. 10.1158/1535-7163.MCT-09-1173.
Article
CAS
PubMed
Google Scholar
Dai Y, Siemann DW: BMS-777607, a small-molecule met kinase inhibitor, suppresses hepatocyte growth factor-stimulated prostate cancer metastatic phenotype in vitro. Mol Cancer Ther. 2010, 9 (6): 1554-1561. 10.1158/1535-7163.MCT-10-0359.
Article
CAS
PubMed
Google Scholar