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  1. Current evidence indicates sub-optimal incidence of fertility preservation (FP) in eligible patients. We present herein our designated multidisciplinary program for FP in pediatric and adolescent population an...

    Authors: Irit Ben-Aharon, R. Abir, G. Perl, J. Stein, G. Gilad, H. Toledano, S. Elitzur, G. Avrahami, A. Ben-Haroush, G. Oron, E. Freud, D. Kravarusic, M. Ben-Arush, G. Herzel, I. Yaniv, S. M. Stemmer…
    Citation: BMC Cancer 2016 16:620
    Content type: Research article Published on:

  2. Anthracyclines, as the most effective therapy, are the cornerstone of advanced stage sarcoma treatment. However, anthracyclines can also contribute to myocardial dysfunction and congestive heart failure, ultim...

    Authors: Markus K. Schuler, Sebastian Gerdes, Antje West, Stephan Richter, Christoph Busemann, Leopold Hentschel, Felicitas Lenz, Hans-Georg Kopp, Gerhard Ehninger, Peter Reichardt and Daniel Pink
    Citation: BMC Cancer 2016 16:619
    Content type: Research article Published on:

  3. The minor allele of two caspase 8 polymorphisms, namely CASP8 -652 6N InsDel (rs3834129) and CASP8 Asp302His (rs1045485), were repeatedly associated with reduced breast cancer susceptibility. Contrarily, the pres...

    Authors: J. D. Kuhlmann, A. Bankfalvi, K. W. Schmid, R. Callies, R. Kimmig, P. Wimberger, W. Siffert and H. S. Bachmann
    Citation: BMC Cancer 2016 16:618
    Content type: Research article Published on:

  4. Class I histone deacetylases (HDACs) have been reported to be overexpressed in clear cell renal cell carcinoma (ccRCC), whereas the expression of class II HDACs is unknown.

    Authors: Swathi Ramakrishnan, ShengYu Ku, Eric Ciamporcero, Kiersten Marie Miles, Kris Attwood, Sreenivasulu Chintala, Li Shen, Leigh Ellis, Paula Sotomayor, Wendy Swetzig, Ray Huang, Dylan Conroy, Ashley Orillion, Gokul Das and Roberto Pili
    Citation: BMC Cancer 2016 16:617
    Content type: Research article Published on:

  6. Due to lack of a targeted therapy for the triple-negative breast cancer (TNBC) patients, it is important to explore this aggressive breast cancer type in more detail and to establish novel therapeutic approach...

    Authors: Michaela C. Huber, Rebecca Mall, Herbert Braselmann, Annette Feuchtinger, Sara Molatore, Katrin Lindner, Axel Walch, Eva Gross, Manfred Schmitt, Natalie Falkenberg and Michaela Aubele
    Citation: BMC Cancer 2016 16:615
    Content type: Research article Published on:

  7. Circulating tumor cells (CTCs) have shown prognostic relevance in many cancer types. However, the majority of current CTC capture methods rely on positive selection techniques that require a priori knowledge a...

    Authors: Weiqiang Chen, Steven G. Allen, Ajaya Kumar Reka, Weiyi Qian, Shuo Han, Jianing Zhao, Liwei Bao, Venkateshwar G. Keshamouni, Sofia D. Merajver and Jianping Fu
    Citation: BMC Cancer 2016 16:614
    Content type: Research article Published on:

  8. Although the introduction of novel agents improved the survival outcomes in patients with multiple myeloma (MM), some patients died within one year (early mortality, EM) following diagnosis. In this study, we ...

    Authors: Sung-Hoon Jung, Min-Seok Cho, Hee Kyung Kim, Seok Jin Kim, Kihyun Kim, June-Won Cheong, Soo-Jeoong Kim, Jin Seok Kim, Jae-Sook Ahn, Yeo-Kyeoung Kim, Deok-Hwan Yang, Hyeoung-Joon Kim and Je-Jung Lee
    Citation: BMC Cancer 2016 16:613
    Content type: Research article Published on:

  9. Thrombocytosis has been associated with poor ovarian cancer prognosis. However, comparisons of thresholds to define thrombocytosis and evaluation of relevant timing of platelet measurement has not been previou...

    Authors: Gabriella D. Cozzi, Jacob M. Samuel, Jason T. Fromal, Spencer Keene, Marta A. Crispens, Dineo Khabele and Alicia Beeghly-Fadiel
    Citation: BMC Cancer 2016 16:612
    Content type: Research article Published on:

  10. Glioblastoma (GBM) tumors exhibit strong phenotypic differences that can be quantified using magnetic resonance imaging (MRI), but the underlying biological drivers of these imaging phenotypes remain largely u...

    Authors: Patrick Grossmann, David A. Gutman, William D. Dunn Jr, Chad A. Holder and Hugo J. W. L. Aerts
    Citation: BMC Cancer 2016 16:611
    Content type: Research article Published on:

  13. Association between cancer survival and socioeconomic status has been reported in various countries but it has never been studied in Portugal. We aimed here to study the role of education and socioeconomic dep...

    Authors: Luís Antunes, Denisa Mendonça, Maria José Bento and Bernard Rachet
    Citation: BMC Cancer 2016 16:608
    Content type: Research article Published on:

  14. Prostate cancer (PCa) is the most commonly diagnosed malignancy reported to Australian cancer registries with numerous studies from individual registries summarizing diagnostic and treatment characteristics. T...

    Authors: Rasa Ruseckaite, Kerri Beckmann, Michael O’Callaghan, David Roder, Kim Moretti, Jeremy Millar and Sue Evans
    Citation: BMC Cancer 2016 16:607
    Content type: Research article Published on:

  15. The response to neoadjuvant chemotherapy has been proven to predict long-term clinical benefits for patients. Our research is to construct a nomogram to predict pathological complete response of human epiderma...

    Authors: Xi Jin, Yi-Zhou Jiang, Sheng Chen, Ke-Da Yu, Ding Ma, Wei Sun, Zhi-Min Shao and Gen-Hong Di
    Citation: BMC Cancer 2016 16:606
    Content type: Research article Published on:

  16. MicroRNA-21 (miR-21) is up-regulated in many cancers, including colorectal cancer (CRC). Nevertheless, the function of miR-21 in CRC and the mechanism underlying that function is still unclear.

    Authors: Chenli Li, Lingxu Zhao, Yuan Chen, Tiantian He, Xiaowan Chen, Jiating Mao, Chunmei Li, Jianxin Lyu and Qing H. Meng
    Citation: BMC Cancer 2016 16:605
    Content type: Research article Published on:

  17. Radioresistant glioblastoma stem cells (GSCs) contribute to tumor recurrence and identification of the molecular targets involved in radioresistance mechanisms is likely to enhance therapeutic efficacy. This s...

    Authors: Anaïs Balbous, Ulrich Cortes, Karline Guilloteau, Pierre Rivet, Baptiste Pinel, Mathilde Duchesne, Julie Godet, Odile Boissonnade, Michel Wager, René Jean Bensadoun, Jean-Claude Chomel and Lucie Karayan-Tapon
    Citation: BMC Cancer 2016 16:604
    Content type: Research article Published on:

  18. Identification of targetable EML4-ALK fusion proteins has revolutionized the treatment of a minor subgroup of non-small cell lung cancer (NSCLC) patients. Although fluorescence in situ hybridization (FISH) is ...

    Authors: Johanna S. M. Mattsson, Hans Brunnström, Verena Jabs, Karolina Edlund, Karin Jirström, Stephanie Mindus, Linnéa la Fleur, Fredrik Pontén, Mats G. Karlsson, Christina Karlsson, Hirsh Koyi, Eva Brandén, Johan Botling, Gisela Helenius, Patrick Micke and Maria A. Svensson
    Citation: BMC Cancer 2016 16:603
    Content type: Research article Published on:

  19. The S6 Kinase (S6K) proteins are some of the main downstream effectors of the mammalian Target Of Rapamycin (mTOR) and act as key regulators of protein synthesis and cell growth. S6K is overexpressed in a vari...

    Authors: Camila L. Amaral, Lidia B. Freitas, Rodrigo E. Tamura, Mariana R. Tavares, Isadora C. B. Pavan, Marcio C. Bajgelman and Fernando M. Simabuco
    Citation: BMC Cancer 2016 16:602
    Content type: Research article Published on:

  20. Lymphedema is a prevalent long-term effect of breast cancer treatment that is associated with reduced quality of life. More recent observational data suggest that the addition of night-time compression to day-...

    Authors: Margaret L. McNeely, Kristin L. Campbell, Marc Webster, Urve Kuusk, Karen Tracey and John Mackey
    Citation: BMC Cancer 2016 16:601
    Content type: Study protocol Published on:

  22. The screening of ROS proto-oncogene 1, receptor tyrosine kinase(ROS1) fusion rearrangement might be potentially beneficial for an effective therapy against non-small cell lung cancer (NSCLC). However, the thre...

    Authors: Jieyu Wu, Yunen Lin, Xinming He, Haihong Yang, Ping He, Xinge Fu, Guangqiu Li and Xia Gu
    Citation: BMC Cancer 2016 16:599
    Content type: Research article Published on:

  23. Mantle cell lymphoma (MCL) is a rare and aggressive form of non-Hodgkin’s lymphoma. Bortezomib is the first product to be approved for the treatment of patients with previously untreated MCL, for whom haematop...

    Authors: Marjolijn van Keep, Kerry Gairy, Divyagiri Seshagiri, Pushpike Thilakarathne and Dawn Lee
    Citation: BMC Cancer 2016 16:598
    Content type: Research article Published on:

  24. Germ cell neoplasia in situ (GCNIS), is preinvasive stage of testicular germ cell tumours (TGCTs). Fibrillins, which are integral components of microfibrils are suggested to be involved in cancer pathogenesis ...

    Authors: Z. Cierna, M. Mego, I. Jurisica, K. Machalekova, M. Chovanec, V. Miskovska, D. Svetlovska, K. Kalavska, K. Rejlekova, K. Kajo, J. Mardiak and P. Babal
    Citation: BMC Cancer 2016 16:597
    Content type: Research article Published on:

  27. We previously identified CK1α as a novel tumor suppressor in melanoma and reported that the loss of CK1α leads to increased proliferation and invasive growth of melanoma cells by strong activation of the Wnt/β...

    Authors: Tobias Sinnberg, Jun Wang, Birgit Sauer and Birgit Schittek
    Citation: BMC Cancer 2016 16:594
    Content type: Research article Published on:

  28. Breast metastasis from lung cancer has been reported, but not from SCLC that is transformed from lung adenocarcinoma during maintenance treatment with epidermal growth factor receptor tyrosine kinase inhibitor...

    Authors: Quan Lin, Guo-ping Cai, Kai-Yan Yang, Li Yang, Cheng-Shui Chen and Yu-Ping Li
    Citation: BMC Cancer 2016 16:593
    Content type: Case report Published on:

  29. In the lung, melanoma is mostly arranged as patterns of multiple nodules, solitary nodules, or miliary invasions. Very rarely, it also displays a “crazy paving” pattern (also described as a “paving stone,” “fl...

    Authors: Yikuan Feng, Jianping Zhao, Qun Yang, Weining Xiong, Guohua Zhen, Yongjian Xu, Zhenxiang Zhang and Huilan Zhang
    Citation: BMC Cancer 2016 16:592
    Content type: Case report Published on:

  30. Experimental evidence and clinical studies in breast cancer suggest that some anti-tumor therapy regimens generate stimulation of the immune system that accounts for tumor clinical responses, however, demonstr...

    Authors: David Bernal-Estévez, Ramiro Sánchez, Rafael E. Tejada and Carlos Parra-López
    Citation: BMC Cancer 2016 16:591
    Content type: Research article Published on:

  31. Liver biopsies in pediatric hematopoietic stem cell transplantation (HSCT) patients are as and effective when performed at bedside in the Bone Marrow Transplant Unit (BMTU) than in the Day Surgery Unit (DSU), ...

    Authors: Natalia Maximova, Massimo Gregori, Francesca Barbieri, Antonio Pizzol and Aurelio Sonzogni
    Citation: BMC Cancer 2016 16:590
    Content type: Research article Published on:

  32. In this retrospective study we evaluated the respective correlations and clinical relevance of FOLR1 mRNA expression, FOLR1 promoter specific methylation and global DNA hypomethylation in type I and type II ov...

    Authors: Sara Notaro, Daniel Reimer, Heidi Fiegl, Gabriel Schmid, Annamarie Wiedemair, Julia Rössler, Christian Marth and Alain Gustave Zeimet
    Citation: BMC Cancer 2016 16:589
    Content type: Research article Published on:

  33. Radiation recall gastritis is rare but can be induced after concurrent chemoradiation for pancreatic cancer. We report a patient with pancreatic cancer who developed radiation-recall gastritis related to a com...

    Authors: Seong Ji Choi, Hyo Jung Kim, Jae Seon Kim, Young-Tae Bak and Jun Suk Kim
    Citation: BMC Cancer 2016 16:588
    Content type: Case report Published on:

  34. The basal-like breast cancer (BLBC) subtype is characterized by positive staining for basal mammary epithelial cytokeratin markers, lack of hormone receptor and HER2 expression, and poor prognosis with current...

    Authors: Qing-Bai She, Sofia K. Gruvberger-Saal, Matthew Maurer, Yilun Chen, Mervi Jumppanen, Tao Su, Meaghan Dendy, Ying-Ka Ingar Lau, Lorenzo Memeo, Hugo M. Horlings, Marc J. van de Vijver, Jorma Isola, Hanina Hibshoosh, Neal Rosen, Ramon Parsons and Lao H. Saal
    Citation: BMC Cancer 2016 16:587
    Content type: Research article Published on:

  35. Prostate cancer is one of the most common male cancers worldwide. Active Surveillance (AS) has been developed to allow men with lower risk disease to postpone or avoid the adverse side effects associated with ...

    Authors: Eimear Ruane-McAteer, Joe O’Sullivan, Sam Porter, Lionne Venderbos and Gillian Prue
    Citation: BMC Cancer 2016 16:586
    Content type: Study protocol Published on:

  36. KRAS mutation testing is mandatory in the management of metastatic colorectal cancer prior to treatment with anti-EGFR antibodies as patients whose tumors express mutant KRAS do not benefit from these agents. Alt...

    Authors: Elisabeth Mack, Kathleen Stabla, Jorge Riera-Knorrenschild, Roland Moll, Andreas Neubauer and Cornelia Brendel
    Citation: BMC Cancer 2016 16:585
    Content type: Research article Published on:

  37. NF-kB can function as an oncogene or tumor suppressor depending on cancer types. The role of NF-kB in low-grade serous ovarian cancer, however, has never been tested. We sought to elucidate the function of NF-...

    Authors: Xue Xiao, Gong Yang, Peng Bai, Shunping Gui, Tri M. Bui Nyuyen, Imelda Mercado-Uribe, Mei Yang, Juan Zou, Qintong Li, Jianguo Xiao, Bin Chang, Guangzhi Liu, He Wang and Jinsong Liu
    Citation: BMC Cancer 2016 16:582
    Content type: Research article Published on:

  38. Total laryngectomy with or without adjuvant (chemo)radiation often induces speech, swallowing and neck and shoulder problems. Speech, swallowing and shoulder exercises may prevent or diminish these problems. T...

    Authors: Femke Jansen, Ingrid C. Cnossen, Simone E. J. Eerenstein, Veerle M. H. Coupé, Birgit I. Witte, Cornelia F. van Uden-Kraan, Patricia Doornaert, Weibel W. Braunius, Remco De Bree, José A. U. Hardillo, Jimmie Honings, György B. Halmos, C. René Leemans and Irma M. Verdonck-de Leeuw
    Citation: BMC Cancer 2016 16:580
    Content type: Study protocol Published on:

  39. Pancreatic cancer has a dire prognosis and is associated with a high mortality. Palliative patients have special needs and often seek help in integrative oncological concepts (IO) that combine conventional and...

    Authors: Jan Axtner, Megan Steele, Matthias Kröz, Günther Spahn, Harald Matthes and Friedemann Schad
    Citation: BMC Cancer 2016 16:579
    Content type: Research article Published on:

  40. Chemoresistance is one of the most leading causes for tumor progression and recurrence of bladder cancer. Reactive oxygen species (ROS) plays a key role in the chemosensitivity of cancer cells. In the present ...

    Authors: Xinxing Li, Haolu Wang, Juan Wang, Yuying Chen, Xiaobin Yin, Guiying Shi, Hui Li, Zhiqian Hu and Xiaowen Liang
    Citation: BMC Cancer 2016 16:578
    Content type: Research article Published on:

  41. Volume-based parameters, such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG), on F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) are useful for predicting treatment response...

    Authors: Tomoka Kitao, Kenji Hirata, Katsumi Shima, Takashi Hayashi, Mitsunori Sekizawa, Toshiki Takei, Wataru Ichimura, Masao Harada, Keishi Kondo and Nagara Tamaki
    Citation: BMC Cancer 2016 16:576
    Content type: Research article Published on:

  42. Active fibroblasts, the predominant and the most active cells of breast cancer stroma, are responsible for tumor growth and spread. However, the molecular mediators and pathways responsible for stromal fibrobl...

    Authors: Maha A. Al-Rakan, Siti-Faujiah Hendrayani and Abdelilah Aboussekhra
    Citation: BMC Cancer 2016 16:575
    Content type: Research article Published on:

  43. Fibronectin is a mechanically sensitive protein which is organized in the extracellular matrix as a network of interacting fibrils. The lung tumor stroma is enriched for fibronectin which is thought to contrib...

    Authors: Christina Cho, Carol Horzempa, David Jones and Paula J. McKeown-Longo
    Citation: BMC Cancer 2016 16:574
    Content type: Research article Published on:

  44. HELLP syndrome is a combination of symptoms described as hemolysis, elevated liver enzymes and low platelets, that complicates 0.01–0.6 % of pregnancies. HELLP syndrome has been scarcely reported associated wi...

    Authors: Guillaume Vogin, François Golfier, Touria Hajri, Agnès Leroux and Béatrice Weber
    Citation: BMC Cancer 2016 16:573
    Content type: Case report Published on:

  45. Imatinib-resistant chronic myeloid leukemia (CML) patients receiving second-line tyrosine kinase inhibitor (TKI) therapy with dasatinib or nilotinib have a higher risk of disease relapse and progression and no...

    Authors: Simona Soverini, Caterina De Benedittis, Fausto Castagnetti, Gabriele Gugliotta, Manuela Mancini, Luana Bavaro, Katerina Machova Polakova, Jana Linhartova, Alessandra Iurlo, Domenico Russo, Fabrizio Pane, Giuseppe Saglio, Gianantonio Rosti, Michele Cavo, Michele Baccarani and Giovanni Martinelli
    Citation: BMC Cancer 2016 16:572
    Content type: Technical advance Published on:

  46. Cell-penetrating peptides (CPPs) are a research hotspot due to their noninvasive delivery ability. Among the identified CPPs, the TAT and R8 peptides have been preferentially applied to transduction into diffe...

    Authors: Lifeng Wang, Haijin Chen, Jinlong Yu, Xiaohua Lin, Jia Qi, Chunhui Cui, Lang Xie and Shuxin Huang
    Citation: BMC Cancer 2016 16:571
    Content type: Research article Published on:

  47. The role of microRNA-200 (miR-200) family members in the migration and invasion of breast cancer is controversial. This study investigated the mechanisms by which the miR-200 family members modulated the migra...

    Authors: Sul Ki Choi, Hoe Suk Kim, Tiefeng Jin, Eun Hye Hwang, Minji Jung and Woo Kyung Moon
    Citation: BMC Cancer 2016 16:570
    Content type: Research article Published on:

  48. Many factors contribute to socioeconomic status (SES), yet in most survival studies only income is used as a measure for determining SES. We used a complex, composite, census-based metric for socioeconomic dep...

    Authors: Ajit Auluck, Blake Byron Walker, Greg Hislop, Scott A. Lear, Nadine Schuurman and Miriam Rosin
    Citation: BMC Cancer 2016 16:569
    Content type: Research article Published on:

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