Shaw AT, Kim DW, Nakagawa K, Seto T, Crino L, Ahn MJ, De Pas T, Besse B, Solomon BJ, Blackhall F, Wu YL, Thomas M, O'Byrne KJ, Moro-Sibilot D, Camidge DR, Mok T, Hirsh V, Riely GJ, Iyer S, Tassell V, Polli A, Wilner KD, Janne PA. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med. 2013;368(25):2385–94. doi:10.1056/NEJMoa1214886.
Article
CAS
PubMed
Google Scholar
Weickhardt AJ, Aisner DL, Franklin WA, Varella-Garcia M, Doebele RC, Camidge DR. Diagnostic assays for identification of anaplastic lymphoma kinase-positive non-small cell lung cancer. Cancer. 2013;119(8):1467–77. doi:10.1002/cncr.27913. PubMed PMID: 23280244; PMCID: 3935240.
Article
CAS
PubMed
Google Scholar
Coco S, Truini A, Vanni I, Dal Bello MG, Alama A, Rijavec E, Genova C, Barletta G, Sini C, Burrafato G, Biello F, Boccardo F, Grossi F. Next generation sequencing in non-small cell lung cancer: new avenues toward the personalized medicine. Curr Drug Targets. 2015;16(1):47–59.
Article
CAS
PubMed
Google Scholar
Ali SM, Hensing T, Schrock AB, Allen J, Sanford E, Gowen K, Kulkarni A, He J, Suh JH, Lipson D, Elvin JA, Yelensky R, Chalmers Z, Chmielecki J, Peled N, Klempner SJ, Firozvi K, Frampton GM, Molina JR, Menon S, Brahmer JR, MacMahon H, Nowak J, Ou SH, Zauderer M, Ladanyi M, Zakowski M, Fischbach N, Ross JS, Stephens PJ, Miller VA, Wakelee H, Ganesan S, Salgia R. Comprehensive Genomic Profiling Identifies a Subset of Crizotinib-Responsive ALK-Rearranged Non-Small Cell Lung Cancer Not Detected by Fluorescence In Situ Hybridization. Oncologist. 2016;21(6):762–70. doi:10.1634/theoncologist.2015-0497.
Article
PubMed
Google Scholar
Pfizer L. Xalkori® FDA-approved prescribing information. NY: Pfizer Inc; 2015. LAB-0441-7.0(September).
Google Scholar
Camidge DR, Bang YJ, Kwak EL, Iafrate AJ, Varella-Garcia M, Fox SB, Riely GJ, Solomon B, Ou SH, Kim DW, Salgia R, Fidias P, Engelman JA, Gandhi L, Janne PA, Costa DB, Shapiro GI, Lorusso P, Ruffner K, Stephenson P, Tang Y, Wilner K, Clark JW, Shaw AT. Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study. Lancet Oncol. 2012;13(10):1011–9. doi:10.1016/S1470-2045(12)70344-3. PubMed PMID: 22954507; PMCID: 3936578.
Article
CAS
PubMed
PubMed Central
Google Scholar
Doebele RC, Pilling AB, Aisner DL, Kutateladze TG, Le AT, Weickhardt AJ, Kondo KL, Linderman DJ, Heasley LE, Franklin WA, Varella-Garcia M, Camidge DR. Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer. Clin Cancer Res. 2012;18(5):1472–82. doi:10.1158/1078-0432.CCR-11-2906. PubMed PMID: 22235099; PMCID: 3311875.
Article
CAS
PubMed
PubMed Central
Google Scholar
Katayama R, Shaw AT, Khan TM, Mino-Kenudson M, Solomon BJ, Halmos B, Jessop NA, Wain JC, Yeo AT, Benes C, Drew L, Saeh JC, Crosby K, Sequist LV, Iafrate AJ, Engelman JA. Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers. Sci Transl Med. 2012;4(12):120ra17. doi:10.1126/scitranslmed.3003316. PubMed PMID: 22277784; PMCID: 3385512.
PubMed
PubMed Central
Google Scholar
Romanidou O, Landi L, Cappuzzo F, Califano R. Overcoming resistance to first/second generation epidermal growth factor receptor tyrosine kinase inhibitors and ALK inhibitors in oncogene-addicted advanced non-small cell lung cancer. Ther Adv Med Oncol. 2016;8(3):176–87. doi:10.1177/1758834016631531. PubMed PMID: 27239236; PMCID: 4872250.
Article
PubMed
PubMed Central
Google Scholar
Camidge DR, Pao W, Sequist LV. Acquired resistance to TKIs in solid tumours: learning from lung cancer. Nat Rev Clin Oncol. 2014;11(8):473–81. doi:10.1038/nrclinonc.2014.104.
Article
CAS
PubMed
Google Scholar
Choi YL, Soda M, Yamashita Y, Ueno T, Takashima J, Nakajima T, Yatabe Y, Takeuchi K, Hamada T, Haruta H, Ishikawa Y, Kimura H, Mitsudomi T, Tanio Y, Mano H, Group ALKLCS. EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors. N Engl J Med. 2010;363(18):1734–9. doi:10.1056/NEJMoa1007478.
Article
CAS
PubMed
Google Scholar
Li N, Michellys P-Y, Kim S, Pferdekamper AC, Li J, Kasibhatla S, Tompkins CS, Steffy A, Li A, Sun F, Sun X, Hua S, Tiedt R, Sarkisova Y, Marsilje TH, McNamara P, Harris J. Abstract B232: Activity of a potent and selective phase I ALK inhibitor LDK378 in naive and crizotinib-resistant preclinical tumor models. Am Assoc Cancer Res. 2011;10(11 Supplement):B232–B. doi:10.1158/1535-7163.targ-11-b232.
Google Scholar
Novartis P. ZykadiaTM FDA-approved prescribing information 2015;T2015-114/T2015-115(July).
Kim D, Mehra R, Tan DSW, Felip E, Chow LQM, Camidge DR, Vansteenkiste J, Sharma S, De Pas T, Riely GJ, Solomon BJ, Wolf J, Thomas M, Schuler M, Liu G, Santoro A, Geraldes M, Boral AL, Yovine A, Shaw AT. Efficacy and Safety of Ceritinib in Patients With Advanced Anaplastic Lymphoma Kinase (ALK)-Rearranged (ALK plus) Non-Small Cell Lung Cancer (NSCLC): An Update of ASCEND-1. Int J Radiat Oncol. 2014;90:S33–S4. PubMed PMID: WOS:000346413500071.
Article
Google Scholar
Schaefer ES, Baik C. Proactive management strategies for potential gastrointestinal adverse reactions with ceritinib in patients with advanced ALK-positive non-small-cell lung cancer. Cancer Manag Res. 2016;8:33–8. doi:10.2147/CMAR.S96471. PubMed PMID: 27069372; PMCID: 4818057.
Article
PubMed
PubMed Central
Google Scholar
Nokihara H. Alectinib (ALC) versus crizotinib (CRZ) in ALK-inhibitor naive ALK-positive non-small cell lung cancer (ALK+ NSCLC): Primary results from the J-ALEX study. ASCO 2016. Abstract 9008.