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  1. Tumor-infiltrating lymphocytes (TILs) by routine hematoxylin and eosin staining (H&E-TILs) are a robust prognostic biomarker in various cancers. However, the role of H&E-TILs in esophageal squamous cell carcin...

    Authors: Jifang Zheng, Hejun Zhang, Siya Li, Zhaoxin Kang, Fei Zheng, Qiwei Yao, Xueqing Zhang, Ziyi Wu, Jiezhong Wang, Weimin Fang, Jiancheng Li, Gang Chen, Yuangui Chen and Mingqiu Chen
    Citation: BMC Cancer 2023 23:1193
    Content type: Research Published on:

  2. The current gastric cancer staging system relies on the number of metastatic lymph nodes (MLNs) for nodal stage determination. However, incorporating additional information such as topographic status may help ...

    Authors: Chul-Hyo Jeon, Ki Bum Park, Hayemin Lee, Dong Jin Kim, Ho Seok Seo, Junhyun Lee, Kyung Hwa Jun, Jin Jo Kim and Han Hong Lee
    Citation: BMC Cancer 2023 23:1192
    Content type: Research Published on:

  3. Patients diagnosed with low-risk prostate cancer (PCa) are confronted with a difficult decision regarding whether to undergo definitive treatment or to pursue an active surveillance protocol. This is potential...

    Authors: Alice Guan, Eduardo J. Santiago-Rodríguez, Benjamin I. Chung, Janet K. Shim, Laura Allen, Mei-Chin Kuo, Kathie Lau, Zinnia Loya, James D. Brooks, Iona Cheng, Mindy C. DeRouen, Dominick L. Frosch, Todd Golden, John T. Leppert, Daphne Y. Lichtensztajn, Qian Lu…
    Citation: BMC Cancer 2023 23:1191
    Content type: Research Published on:

  5. Colorectal cancer (CRC) is a leading cause of cancer-related mortality, highlighting an unmet clinical need for more effective therapies. This study aims to evaluate the causal relationship between 4,489 plasm...

    Authors: Yi-Xin Cai, Yi-Qing Wu, Jie Liu, Huanle Pan, Wenhai Deng, Weijian Sun, Congying Xie and Xiu-Feng Huang
    Citation: BMC Cancer 2023 23:1188
    Content type: Research Published on:

  6. Chemoradiation therapy (CRT) followed by surgery is currently the standard of care to treat patients with locally advanced rectal cancer (LARC). CRT reduces local recurrences, but is associated with significan...

    Authors: D. M. Mens, J. M. van Rees, S. M. Wilting and C. Verhoef
    Citation: BMC Cancer 2023 23:1187
    Content type: Study Protocol Published on:

  7. Less than half of unselected metastatic cancer patients benefit from the immune checkpoint inhibitor (ICI) therapy. Systemic cancer-related inflammation may influence the efficacy of ICIs and thus, systemic in...

    Authors: Satu Tiainen, Veera Nurmela, Tuomas Selander, Patrik Turunen, Sanna Pasonen-Seppänen, Tiia Kettunen, Outi Kuittinen, Päivi Auvinen and Aino Rönkä
    Citation: BMC Cancer 2023 23:1186
    Content type: Research Published on:

  8. Hepatocellular carcinoma (HCC) is a major health concern, necessitating a deeper understanding of its prognosis and underlying mechanisms. This study aimed to investigate the mechanism and prognostic value of CD8

    Authors: Kejun Liu, Junhao Liu, Xusheng Zhang, Di Liu, Weijie Yao, Yang Bu and Bendong Chen
    Citation: BMC Cancer 2023 23:1185
    Content type: Research Published on:

  9. Up to the present time, there has remained a lack of strong evidence as to whether sentinel lymph node biopsy can replace lymphadenectomy for early endometrial cancer. The traditional surgery for endometrial c...

    Authors: Yanglong Guo, Lu Sun, Xi Chen, Qiang Wen, Zhuyan Shao, Xuedong Tang, XiaoJun Shi, Jinyu Wang, Yingli Zhang and Tao Zhu
    Citation: BMC Cancer 2023 23:1184
    Content type: Study protocol Published on:

  10. Obesity is a risk factor for breast cancer, and women with obesity that develop breast cancer have a worsened prognosis. Within the mammary gland, obesity causes chronic, macrophage-driven inflammation and adi...

    Authors: Genevra Kuziel, Brittney N. Moore, Grace P. Haugstad, Yue Xiong, Abbey E. Williams and Lisa M. Arendt
    Citation: BMC Cancer 2023 23:1183
    Content type: Research Published on:

  11. Patients diagnosed with small cell lung cancer (SCLC) typically experience a poor prognosis, and it is essential to predict overall survival (OS) and stratify patients based on distinct prognostic risks.

    Authors: Ziqian Song, Hengmin Ma, Hao Sun, Qiuxia Li, Yan Liu, Jing Xie, Yukun Feng, Yuwang Shang, Kena Ma, Nan Zhang and Jialin Wang
    Citation: BMC Cancer 2023 23:1182
    Content type: Research Published on:

  12. The predictive biomarkers of immune checkpoint inhibitors (ICIs) in hepatocellular carcinoma (HCC) still need to be further explored. This study aims to establish a new immune prognosis biomarker to predict th...

    Authors: Rujia Zhang, Haoran Zhao, Peng Wang, Zuoming Guo, Chunxun Liu and Zhaowei Qu
    Citation: BMC Cancer 2023 23:1181
    Content type: Research Published on:

  14. Osteosarcoma (OS) is the most common primary malignancy of bone tumors. More and more ARHGAP family genes have been confirmed are to the occurrence, development, and invasion of tumors. However, its significan...

    Authors: Wenda Liu, Kezhou Xia, Di Zheng, Xinghan Huang, Zhun Wei, Zicheng Wei and Weichun Guo
    Citation: BMC Cancer 2023 23:1179
    Content type: Research Published on:

  15. Many patients treated for breast cancer (BC) complain about cognitive difficulties affecting their daily lives. Recently, sleep disturbances and circadian rhythm disruptions have been brought to the fore as po...

    Authors: Clara Elia, Laura de Girolamo, Bénédicte Clarisse, Melvin Galin, Stéphane Rehel, Patrice Clochon, Franck Doidy, Shailendra Segobin, Fausto Viader, Mikaël Naveau, Nicolas Delcroix, Carine Segura-Djezzar, Jean-Michel Grellard, Justine Lequesne, Olivier Etard, Tristan Martin…
    Citation: BMC Cancer 2023 23:1178
    Content type: Study Protocol Published on:

  16. Breast cancer (BC) is one of the malignant diseases threatening the life and health of women worldwide. The CYP4B1 gene was abnormally expressed in BC and was associated with the prognosis of BC patients. This st...

    Authors: Yanhai Yin, Liangqian Tong, Zhenling Wan, Yanfang Sui, Fen Li, Qian Huang and Xinhan Zhao
    Citation: BMC Cancer 2023 23:1177
    Content type: Research Published on:

  18. Previous studies on cancer of unknown primary (CUP) mainly focus on treatment and prognosis in western populations and lacked clinical evaluation of different IHC markers, so this study aimed to evaluate chara...

    Authors: Min Ren, Xu Cai, Liqing Jia, Qianming Bai, Xiaoli Zhu, Xichun Hu, Qifeng Wang, Zhiguo Luo and Xiaoyan Zhou
    Citation: BMC Cancer 2023 23:1175
    Content type: Research Published on:

  19. In order to deliver appropriate and timely care planning and minimise avoidable late diagnoses, clinicians need to be aware of which patients are at higher risk of receiving a late cancer diagnosis. We aimed t...

    Authors: Sarah Mills, Peter Donnan, Deans Buchanan and Blair H. Smith
    Citation: BMC Cancer 2023 23:1174
    Content type: Research Published on:

  20. Angiogenesis is an important hallmark of Glioblastoma (GBM) marked by elevated vascular endothelial growth factor-A (VEGF-A) and its receptor 2 (VEGFR-2). As previously reported nimbolide (NBL), trans-chalcone...

    Authors: Anna Senrung, Tanya Tripathi, Joni Yadav, Divya Janjua, Apoorva Chaudhary, Arun Chhokar, Nikita Aggarwal, Udit Joshi, Nidhi Goswami and Alok Chandra Bharti
    Citation: BMC Cancer 2023 23:1173
    Content type: Research Published on:

  21. There is a lack of standard salvage treatment options for recurrent or metastatic nasopharyngeal carcinoma (RM-NPC) that has failed platinum-containing regimens. Breakthroughs in immunotherapy have opened up n...

    Authors: Jian Luo, Wanying Xiao, Fengyang Hua, Yanqing Cao, Dongxia Wang and Xicheng Wang
    Citation: BMC Cancer 2023 23:1172
    Content type: Research Published on:

  22. The aim of the study is to explore the role of preoperative folate receptor-positive circulating tumor cell (FR+CTC) levels in predicting disease-free survival (DFS) and overall survival (OS) in patients with eso...

    Authors: Qiang Zhou, Qiao He, Wenwu He, Chenghao Wang, Guangyuan Liu, Kangning Wang, Haojun Li, Jialong Li, Wenguang Xiao, Qiang Fang, Lin Peng, Yongtao Han, Dongsheng Wang and Xuefeng Leng
    Citation: BMC Cancer 2023 23:1171
    Content type: Research Published on:

  23. Immunoglobulin superfamily 6 (IGSF6) is a novel member of the immunoglobulin superfamily and has been implicated in various diseases. However, the specific role of IGSF6 in the anti-tumor immunity within lung ...

    Authors: Qisi Zheng, Ting Wang, Gechen Jiang, Miao Li, Zhi Zhang, Yuxin Chen and Xinyu Tian
    Citation: BMC Cancer 2023 23:1170
    Content type: Research Published on:

  24. Colorectal cancer (CRC) is one of the most common malignant tumors, influenced by several genetic loci in its clinical phenotypes. The aim of this study was to determine the relationship between the MMP8 gene pol...

    Authors: Shuyong Yu, Jiajia Cheng, Ping Li, Le Tian, Zhuang Chen, Zhaowei Chen, Yongyu Li and Jian Song
    Citation: BMC Cancer 2023 23:1169
    Content type: Research Published on:

  25. Prophylactic irradiation of supraclavicular lymph node drainage areas can improve the regional control rate of lymph node-positive or lymph node-negative disease but a locally-advanced stage breast cancer, and...

    Authors: Li Li, Hongyan Zhang, Linwei Wang, Conghua Xie, Haijun Yu and Yahua Zhong
    Citation: BMC Cancer 2023 23:1168
    Content type: Research Published on:

  26. Some biomarkers collected from routine laboratory tests have shown important value in cancer prognosis. The study aimed to evaluate the prognostic significance of routine laboratory biomarkers in patients with...

    Authors: Rong Cong, Mingyang Li, Wan Xu, Xiaoxin Ma and Shuhe Wang
    Citation: BMC Cancer 2023 23:1167
    Content type: Research Published on:

  27. Paclitaxel and carboplatin is the standard chemotherapy for the treatment of advanced or recurrent endometrial cancer. However, the benefit of adding programmed cell death 1 (PD-1)/programmed death ligand 1 (P...

    Authors: Francisco Cezar Aquino de Moraes, Eric Pasqualotto, Lucca Moreira Lopes, Maria Eduarda Cavalcanti Souza, Anna Luíza Soares de Oliveira Rodrigues, Artur Menegaz de Almeida, Carlos Stecca, Marianne Rodrigues Fernandes and Ney Pereira Carneiro dos Santos
    Citation: BMC Cancer 2023 23:1166
    Content type: Research Published on:

  28. 18F-FDG PET/CT provides precise information about dissemination of lymphoma lesions. Dmax, defined as distance between the two lesions that were farthest apart by PET/CT, was found to be a promising predictor of....

    Authors: Fei Wang, Silu Cui, Luo Lu, Xiaoliang Shao, Feng Yan, Yaqi Liu, Bai He, Jianfeng Wang, Yang Cao, Yanhua Yue, Yuetao Wang and Weiying Gu
    Citation: BMC Cancer 2023 23:1165
    Content type: Research Published on:

  29. Vaginal CO2 laser therapy is a new treatment option for genitourinary syndrome of menopause. Its potential is particularly interesting in breast cancer survivors, where existing treatment options often are insuff...

    Authors: Sine Jacobsen, Marianne Glavind-Kristensen, Anders Bonde Jensen, Axel Forman and Pinar Bor
    Citation: BMC Cancer 2023 23:1164
    Content type: Study Protocol Published on:

  30. The NOD-, LRR- and pyrin domain‑containing 3 (NLRP3) inflammasome is a critical component of the innate immune system. It has been known to play an important role in the carcinogenesis and prognosis of breast ...

    Authors: Qian-mei Zhu, Hui-xian Li, Pei-qing Ma, Lin-xin Wu, Tai-hang Wang, Wen-bin Li, Lin Zhang, Xue Yang, Xiangyi Kong, Yu-lin Sun and Tao Yan
    Citation: BMC Cancer 2023 23:1163
    Content type: Research Published on:

  31. CXC chemokine ligand 3 (CXCL3) is a member of CXC-type chemokine family that is identified as a major regulator in immune and inflammation responses. Recently, numerous evidence indicated that CXCL3 is broadly...

    Authors: Yao Cheng, Xinyan Yang, Lichun Liang, Hua Xin, Xinyu Dong, Weidong Li, Jie Li, Xiaoli Guo, Yue Li, Jian He, Chunbin Zhang and Weiqun Wang
    Citation: BMC Cancer 2023 23:1162
    Content type: Research Published on:

  32. Cantharidin (CTD) is the active ingredient of Chinese medicine, which has been traditionally used in multiple cancers treatment, especially in hepatocellular carcinoma (HCC). However, a comprehensive analysis ...

    Authors: Jia Yan, Yu min Gao, Xiu ling Deng, Hai sheng Wang and Gui tao Shi
    Citation: BMC Cancer 2023 23:1161
    Content type: Research Published on:

  33. Composition of the intestinal microbiota has been correlated to therapeutic efficacy of immune checkpoint inhibitors (ICI) in various cancer entities including melanoma. Prediction of the outcome of such thera...

    Authors: Anastasia Tsakmaklis, Fedja Farowski, Rafael Zenner, Till Robin Lesker, Till Strowig, Hans Schlößer, Jonas Lehmann, Michael von Bergwelt-Baildon, Cornelia Mauch, Max Schlaak, Jana Knuever, Viola Schweinsberg, Lucie M. Heinzerling and Maria J. G. T. Vehreschild
    Citation: BMC Cancer 2023 23:1160
    Content type: Research Published on:

  34. As a histone methyltransferase, suppressor of variegation 3–9 homolog 1 (SUV39H1) plays an important role in the occurrence and development of cancer. To explore the mechanism and biological function of SUV39H...

    Authors: Yanping Zhang, Wanwen Lao, Kaming Yang, Xinyi Kong, Yuetong Li, Xin Yu, Xumeng Wang, Yang Liu, Zhenlin Li, Yilin Deng, Shuping Nie, Changlong Bi, Chao Wu and Aixia Zhai
    Citation: BMC Cancer 2023 23:1159
    Content type: Research Published on:

  35. Thymic epithelial tumors (TETs) are the most common primary neoplasms of the anterior mediastinum. Different risk subgroups of TETs have different prognosis and therapeutic strategies, therefore, preoperative ...

    Authors: Rongji Gao, Jian Zhou, Juan Zhang, Jianzhong Zhu, Tiantian Wang and Chengxin Yan
    Citation: BMC Cancer 2023 23:1158
    Content type: Research Published on:

  36. To compare the computed tomography (CT) images of patients with locally advanced gastric cancer (GC) before and after neoadjuvant chemotherapy (NAC) in order to identify CT features that could predict patholog...

    Authors: Chengzhi Wei, Yun He, Ma Luo, Guoming Chen, Runcong Nie, Xiaojiang Chen, Zhiwei Zhou and Yongming Chen
    Citation: BMC Cancer 2023 23:1157
    Content type: Research Published on:

  37. Urachal cancer is similar to gastrointestinal adenocarcinoma in histology, and gastroscopy/colonoscopy is often administered during perioperative evaluation. However, gastroscopy and colonoscopy have correspon...

    Authors: Ming-rui Luo, Tao-nong Cai, Jiang-li Lu, Zhen-hua Liu, Sheng-jie Guo, Zhuo-wei Liu, Kai Yao, Zi-ke Qin and Yun-lin Ye
    Citation: BMC Cancer 2023 23:1156
    Content type: Research Published on:

  38. The increasing prevalence of cancer detection necessitated practical strategies to deliver highly accurate, beneficial, and dependable processed information together with experimental results. We deleted the c...

    Authors: Marzieh Javadi, Hossein Sazegar and Abbas Doosti
    Citation: BMC Cancer 2023 23:1155
    Content type: Research Published on:

  39. Epithelial, connective tissue and immune cells contribute in various ways to the pathophysiology of HPV positive (HPV+) and HPV negative (HPV-) oropharyngeal squamous cell carcinoma (OPSCC). We aimed to invest...

    Authors: Aris I. Giotakis, Annette Runge, József Dudas, Rudolf Glueckert, Timo Gottfried, Volker H. Schartinger, Johanna Klarer, Avneet Randhawa, Eleonora Caimmi and Herbert Riechelmann
    Citation: BMC Cancer 2023 23:1154
    Content type: Research Published on:

  40. Chronic myeloid leukemia (CML) is effectively treated with tyrosine kinase inhibitors (TKIs), targeting the BCR::ABL1 oncoprotein. Still, resistance to therapy, relapse after treatment discontinuation, and sid...

    Authors: Lukas Häselbarth, Sara Gamali, Domenica Saul, Manuela Krumbholz, Romy Böttcher-Loschinski, Martin Böttcher, Deyu Zou, Markus Metzler, Axel Karow and Dimitrios Mougiakakos
    Citation: BMC Cancer 2023 23:1153
    Content type: Research Published on:

  42. Triple-negative breast cancer (TNBC) is a lethal mammary carcinoma subtype that affects females and is associated with a worse prognosis. Chemotherapy is the only conventional therapy available for patients wi...

    Authors: Basant Emad, Amr Ahmed WalyEldeen, Hebatallah Hassan, Marwa Sharaky, Ismail A Abdelhamid, Sherif Abdelaziz Ibrahim and Hanan RH Mohamed
    Citation: BMC Cancer 2023 23:1151
    Content type: Research Published on:

  43. The role of circulating tumor cells (CTCs) in prognosis prediction has been actively studied in hepatocellular carcinoma (HCC) patients. However, their efficiency in accurately predicting early progression rec...

    Authors: Zhan Lu, Hanghang Ni, Xihua Yang, Lihao Tan, Haixiao Zhuang, Yunning Mo, Xingyu Wei, Lunan Qi and Bangde Xiang
    Citation: BMC Cancer 2023 23:1150
    Content type: Research Published on:

  44. To investigate the potential correlation between piwi-like RNA-mediated gene silencing 1 (PIWIL1) polymorphisms and susceptibility to epithelial ovarian cancer (EOC).

    Authors: Shanshan Liu, Yaping Yan, Zhizhong Cui, Haipeng Feng, Fengmei Zhong, Ziguang Liu, Yan Li, Xiang Ou and Wenjuan Li
    Citation: BMC Cancer 2023 23:1149
    Content type: Research Published on:

  45. Neuroblastoma (NB), the most common extracranial solid malignancy in children, carries a poor prognosis in high-risk disease, thus requiring novel therapeutic approaches. Survivin is overexpressed in NB, has p...

    Authors: Celimene Galiger, Fatema Tuj Zohora, Carmen Dorneburg, Daniel Tews, Klaus-Michael Debatin and Christian Beltinger
    Citation: BMC Cancer 2023 23:1148
    Content type: Research Published on:

  46. Most existing predictive models of hepatocellular carcinoma (HCC) risk after sustained virologic response (SVR) are built on data collected at baseline and therefore have limited accuracy. The current study ai...

    Authors: Yanzheng Zou, Ming Yue, Linna Jia, Yifan Wang, Hongbo Chen, Amei Zhang, Xueshan Xia, Wei Liu, Rongbin Yu, Sheng Yang and Peng Huang
    Citation: BMC Cancer 2023 23:1147
    Content type: Research Published on:

  47. In nasopharyngeal cancer (NPC), women have a lower incidence and mortality rate than men. Whether sex influences the prognosis of NPC patients remains debatable. We retrospectively examined the influence of se...

    Authors: Linchong Cui, Zilu Chen, Fangfang Zeng, Xiaolan Jiang, Xiaoyan Han, Xiaofei Yuan, Shuting Wu, Huiru Feng, Danfan Lin, Wenxuan Lu, Xiong Liu, Xiaohong Peng and Bolong Yu
    Citation: BMC Cancer 2023 23:1146
    Content type: Research Published on:

  48. Neuroblastoma, a neuroendocrine tumor originating from the sympathetic ganglia, is one of the most common malignancies in childhood. RTEL1 is critical in many fundamental cellular processes, such as DNA replicati...

    Authors: Ting Zhang, Chunlei Zhou, Jiejie Guo, Jiamin Chang, Haiyan Wu and Jing He
    Citation: BMC Cancer 2023 23:1145
    Content type: Research Published on:

  49. Our objective was to assess the efficacy and safety of initial hepatic arterial infusion of chemotherapy combined with transarterial chemoembolisation using camrelizumab-eluting Callisphere beads (camrelizumab...

    Authors: Xiaonan Shi, Yang Wang, Jianzhuang Ren, Xinwei Han and Yonghua Bi
    Citation: BMC Cancer 2023 23:1144
    Content type: Research Published on:

  50. Studies examining the relationships of stressful life events and cancer yielded inconsistent findings, while relevant evidence in mainland China is scarce. The current study sought to determine whether experie...

    Authors: Meng Wang, Weiwei Gong, Dianjianyi Sun, Pei Pei, Jun Lv, Canqing Yu and Min Yu
    Citation: BMC Cancer 2023 23:1142
    Content type: Research Published on:

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