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  1. Breast and colorectal cancer are the two most common cancers in Malaysia. Low awareness coupled with stigma and erroneous beliefs delay help-seeking behaviours, lead to late presentation and contribute to poor...

    Authors: Désirée Schliemann, Michael Donnelly, Maznah Dahlui, Siew Yim Loh, Nor Saleha Binti Tamin Ibrahim, Saunthari Somasundaram, Conan Donnelly and Tin Tin Su
    Citation: BMC Cancer 2018 18:881
    Content type: Study protocol Published on:

  2. Although radical surgery remains the cornerstone of cure in resectable gastric cancer, survival remains poor. Current evidence-based (neo)adjuvant strategies have shown to improve outcome, including perioperat...

    Authors: Astrid E. Slagter, Edwin P. M. Jansen, Hanneke W. M. van Laarhoven, Johanna W. van Sandick, Nicole C. T. van Grieken, Karolina Sikorska, Annemieke Cats, Pietje Muller-Timmermans, Maarten C. C. M. Hulshof, Henk Boot, Maartje Los, Laurens V. Beerepoot, Frank P. J. Peters, Geke A. P. Hospers, Boudewijn van Etten, Henk H. Hartgrink…
    Citation: BMC Cancer 2018 18:877
    Content type: Study protocol Published on:

  3. In breast cancer (BC), deregulation of DNA methylation leads to aberrant expressions and functions of key regulatory genes. In our study, we investigated the relationship between the methylation profiles of ge...

    Authors: Lenka Kalinkova, Iveta Zmetakova, Bozena Smolkova, Gabriel Minarik, Tatiana Sedlackova, Viera Horvathova Kajabova, Zuzana Cierna, Michal Mego and Ivana Fridrichova
    Citation: BMC Cancer 2018 18:875
    Content type: Research article Published on:

  4. Although there is a recognition of the importance of fertility to young women with cancer, we do not know who is at risk of distress related to fertility issues following diagnosis. We investigated the determi...

    Authors: Aleksandra Sobota and Gozde Ozakinci
    Citation: BMC Cancer 2018 18:874
    Content type: Research article Published on:

  5. To date, the clinical benefit of topical steroid use has only been demonstrated for radiation dermatitis induced by 50–60 Gy irradiation in breast cancer. However, these agents are also often used clinically f...

    Authors: Sadamoto Zenda, Takuhiro Yamaguchi, Tomoya Yokota, Tempei Miyaji, Tomoe Mashiko, Mari Tanaka, Masahito Yonemura, Misaki Takeno, Tomoka Okano, Toshikatsu Kawasaki, Yuko Nakamori, Shinobu Ishii, Sanae Shimada, Miyuki Kanamaru and Yosuke Uchitomi
    Citation: BMC Cancer 2018 18:873
    Content type: Study protocol Published on:

  6. Adipose-tissue stem cells (ASCs) are subject of intensive research since their successful use in regenerative therapy. The drawback of ASCs is that they may serve as stroma for cancer cells and assist tumor pr...

    Authors: Roberta Fajka-Boja, Annamária Marton, Anna Tóth, Péter Blazsó, Vilmos Tubak, Balázs Bálint, István Nagy, Zoltán Hegedűs, Csaba Vizler and Robert L. Katona
    Citation: BMC Cancer 2018 18:872
    Content type: Research article Published on:

  7. Although our previous study revealed lumbar punctured resveratrol could remarkably prolong the survival of rats bearing orthotopic glioblastomas, it also suggested the administration did not completely suppres...

    Authors: Xue Song, Xiao-Hong Shu, Mo-Li Wu, Xu Zheng, Bin Jia, Qing-You Kong, Jia Liu and Hong Li
    Citation: BMC Cancer 2018 18:871
    Content type: Research article Published on:

  8. Tumor necrosis (TN) correlates with adverse outcomes in numerous solid tumors. However, its prognostic value in renal cell carcinoma (RCC) remains unclear. In this study, we performed a meta-analysis to evaluate ...

    Authors: Lijin Zhang, Zhenlei Zha, Wei Qu, Hu Zhao, Jun Yuan, Yejun Feng and Bin Wu
    Citation: BMC Cancer 2018 18:870
    Content type: Research article Published on:

  9. The MRE11/RAD50/NBS1 (MRN) complex plays an essential role in detecting and repairing double-stranded breaks, and thus the potential roles of MRE11, RAD50 and NBS1 proteins in the pathogenesis of various cance...

    Authors: Vincent Ho, Liping Chung, Amandeep Singh, Vivienne Lea, Askar Abubakar, Stephanie H. Lim, Weng Ng, Mark Lee, Paul de Souza, Joo-Shik Shin and Cheok Soon Lee
    Citation: BMC Cancer 2018 18:869
    Content type: Research article Published on:

  10. Pulmonary imaging often identifies suspicious abnormalities resulting in supplementary diagnostic procedures. This study aims to investigate whether the metabolic fingerprint of plasma allows to discriminate b...

    Authors: K. Vanhove, P. Giesen, O. E. Owokotomo, L. Mesotten, E. Louis, Z. Shkedy, M. Thomeer and P. Adriaensens
    Citation: BMC Cancer 2018 18:868
    Content type: Research article Published on:

  11. The Ki67 Index has been extensively studied as a prognostic biomarker in breast cancer. However, its clinical adoption is largely hampered by the lack of a standardized method to assess Ki67 that limits inter-...

    Authors: Muhammad Khalid Khan Niazi, Caglar Senaras, Michael Pennell, Vidya Arole, Gary Tozbikian and Metin N. Gurcan
    Citation: BMC Cancer 2018 18:867
    Content type: Research article Published on:

  12. Breast cancer (BC) is the most frequent cancer in women with more than 70% of BC patients being treated with hormonal therapy (HT). Among these patients, some report difficulties in remembering what they are s...

    Authors: Mylène Duivon, Joy Perrier, Florence Joly, Idlir Licaj, Jean-Michel Grellard, Bénédicte Clarisse, Christelle Lévy, Philippe Fleury, Sophie Madeleine, Nicolas Lefèvre, Géraldine Rauchs, Grégory Lecouvey, Florence Fraisse, Fausto Viader, Francis Eustache, Béatrice Desgranges…
    Citation: BMC Cancer 2018 18:866
    Content type: Study protocol Published on:

  13. Up to date, investigation of the prognostic value of differentiation status mainly focused on signet ring cell and mucinous gastric cancer. Thus, the present study aims to investigate the clinicopathological f...

    Authors: Fan Feng, Jinqiang Liu, Fei Wang, Gaozan Zheng, Qiao Wang, Shushang Liu, Guanghui Xu, Man Guo, Xiao Lian and Hongwei Zhang
    Citation: BMC Cancer 2018 18:865
    Content type: Research article Published on:

  14. Anthracycline chemotherapy agents are commonly used to treat breast cancer, but also result in cardiac injury, and potentially detrimental effects to vascular and skeletal muscle. Preclinical evidence demonstr...

    Authors: Amy A. Kirkham, D. Ian Paterson, Carla M. Prado, John M. Mackey, Kerry S. Courneya, Edith Pituskin and Richard B. Thompson
    Citation: BMC Cancer 2018 18:864
    Content type: Study protocol Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:75

  15. Cancer risk is associated with serum iron levels. The aim of this study was to evaluate whether haematological parameters reflect serum iron levels and may also be associated with cancer risk.

    Authors: Niwansa Adris, Anita Chai Geik Chua, Matthew William Knuiman, Mark Laurence Divitini, Debbie Trinder and John Kevin Olynyk
    Citation: BMC Cancer 2018 18:863
    Content type: Research article Published on:

  16. The preoperative growth of human glioblastomas (GBMs) has been shown to vary among patients. In animal studies, angiogenesis has been linked to hypoxia and faster growth of GBM, however, its relation to the gr...

    Authors: Vilde Elisabeth Mikkelsen, Anne Line Stensjøen, Unn Sophie Granli, Erik Magnus Berntsen, Øyvind Salvesen, Ole Solheim and Sverre Helge Torp
    Citation: BMC Cancer 2018 18:862
    Content type: Research article Published on:

  17. Despite the fact that the cost-effectiveness of robot-assisted radical cystectomy (RARC) is not yet proven, and open radical (ORC) cystectomy is recommended as the standard of care in patients with high-risk n...

    Authors: C. J. Wijburg, C. T. J. Michels, J. R. Oddens, J. P. C. Grutters, J. A. Witjes and M. M. Rovers
    Citation: BMC Cancer 2018 18:861
    Content type: Study protocol Published on:

  18. Observational studies have reported conflicting results on the impact of mammography service screening programmes on the advanced breast cancer rate (ABCR), a correlation that was firmly established in randomi...

    Authors: M. J. M. Broeders, P. Allgood, S. W. Duffy, S. Hofvind, I. D. Nagtegaal, E. Paci, S. M. Moss and L. Bucchi
    Citation: BMC Cancer 2018 18:860
    Content type: Research article Published on:

  19. This was a prespecified secondary analysis of a randomized trial, which analyzed bone density following stereotactic body radiotherapy (SBRT) versus conventional three-dimensional conformal radiotherapy (3DCRT...

    Authors: Tanja Sprave, Vivek Verma, Robert Förster, Ingmar Schlampp, Katharina Hees, Thomas Bruckner, Tilman Bostel, Rami Ateyah El Shafie, Thomas Welzel, Nils Henrik Nicolay, Jürgen Debus and Harald Rief
    Citation: BMC Cancer 2018 18:859
    Content type: Research article Published on:

  20. The value of hospital registries for describing treatment and survival outcomes for vulval cancer was investigated. Hospital registry data from four major public hospitals in 1984–2016 were used because popula...

    Authors: David Roder, Margaret Davy, Sid Selva-Nayagam, Sellvakumaram Paramasivam, Jacqui Adams, Dorothy Keefe, Ian Olver, Caroline Miller, Elizabeth Buckley, Kate Powell, Kellie Fusco, Dianne Buranyi-Trevarton and Martin K. Oehler
    Citation: BMC Cancer 2018 18:858
    Content type: Research article Published on:

  21. Gastric cancer (GC) is one of the most common malignant diseases with high morbidity and mortality, especially in Asian countries. During the GC developing progress, TIPE2, a member of TNF-alpha induced protei...

    Authors: Wenming Liu, Yanyun Fan, Ying Shi, Zhenhe Lin, Xiaoxiao Huang, Wei Huang, Dongyan Shen and Zhongquan Qi
    Citation: BMC Cancer 2018 18:857
    Content type: Research article Published on:

  22. Melanoma is one of the most invasive and aggressive types of cancer with a very poor prognosis. Surgery remains the most efficient treatment prior melanoma invasion and metastasis formation. However, therapy b...

    Authors: Myra O. Villareal, Yuki Sato, Kyoko Matsuyama and Hiroko Isoda
    Citation: BMC Cancer 2018 18:856
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2018 18:902

  23. Metastatic melanoma is an aggressive form of skin cancer that evades various anti-cancer treatments including surgery, radio-,immuno- and chemo-therapy. TRAIL-induced apoptosis is a desirable method to treat m...

    Authors: Radhika S. Saraf, Aniruddha Datta, Chao Sima, Jianping Hua, Rosana Lopes and Michael Bittner
    Citation: BMC Cancer 2018 18:855
    Content type: Research article Published on:

  24. Bleomycin, etoposide, and cisplatin (BEP) chemotherapy administered every 3 weeks for 4 cycles remains the standard first line treatment for patients with intermediate- and poor-risk metastatic germ cell tumou...

    Authors: Nicola J. Lawrence, Howard Chan, Guy Toner, Martin R. Stockler, Andrew Martin, Sonia Yip, Nicole Wong, Annie Yeung, Danish Mazhar, Farzana Pashankar, Lindsay Frazier, Ray McDermott, Roderick Walker, Hsiang Tan, Ian D. Davis and Peter Grimison
    Citation: BMC Cancer 2018 18:854
    Content type: Study protocol Published on:

  25. It has been shown that the expression of potassium channel tetramerization domain containing 12 (KCTD12) as a regulator of GABAB receptor signaling is reversely associated with gastrointestinal stromal tumors....

    Authors: Mohammad Reza Abbaszadegan, Negin Taghehchian, Liping Li, Azadeh Aarabi and Meysam Moghbeli
    Citation: BMC Cancer 2018 18:853
    Content type: Research article Published on:

  27. Neoadjuvant chemotherapy (NACT) is a standard approach of the multidisciplinary treatment of breast cancer. Depending on the biological subtype a pathological complete response in the breast (bpCR) can be achi...

    Authors: Joerg Heil, Peter Sinn, Hannah Richter, André Pfob, Benedikt Schaefgen, André Hennigs, Fabian Riedel, Bettina Thomas, Marc Thill, Markus Hahn, Jens-Uwe Blohmer, Sherko Kuemmel, Maria Margarete Karsten, Mattea Reinisch, John Hackmann, Toralf Reimer…
    Citation: BMC Cancer 2018 18:851
    Content type: Study protocol Published on:

  28. Tamoxifen treatment of estrogen receptor (ER)-positive breast cancer reduces mortality by 31%. However, over half of advanced ER-positive breast cancers are intrinsically resistant to tamoxifen and about 40% w...

    Authors: Susanne Hultsch, Matti Kankainen, Lassi Paavolainen, Ruusu-Maaria Kovanen, Elina Ikonen, Sara Kangaspeska, Vilja Pietiäinen and Olli Kallioniemi
    Citation: BMC Cancer 2018 18:850
    Content type: Research article Published on:

  29. Chondrosarcoma is the second most frequent primary malignant bone tumor. Treatment is mainly based on surgery. In general, wide resection is advocated at least in G2 and G3 tumors. But which margins should be ...

    Authors: Julian Fromm, Alexander Klein, Andrea Baur-Melnyk, Thomas Knösel, Lars Lindner, Christof Birkenmaier, Falk Roeder, Volkmar Jansson and Hans Roland Dürr
    Citation: BMC Cancer 2018 18:849
    Content type: Research article Published on:

  30. Efficiency of colorectal carcinoma treatment by chemotherapy is diminished as the resistance develops over time in patients. The same holds true for 5-fluorouracil, the drug used in first line chemotherapy of ...

    Authors: Erika Durinikova, Zuzana Kozovska, Martina Poturnajova, Jana Plava, Zuzana Cierna, Andrea Babelova, Roman Bohovic, Silvia Schmidtova, Miroslav Tomas, Lucia Kucerova and Miroslava Matuskova
    Citation: BMC Cancer 2018 18:848
    Content type: Research article Published on:

  31. Numerous studies have investigated the relationship between COX-2 8473 T > C polymorphism and cancer susceptibility, however, the results remain controversial. Therefore, we carried out the present meta-analysis ...

    Authors: Qiuping Li, Chao Ma, Zhihui Zhang, Suhua Chen, Weiguo Zhi, Lei Zhang, Guoyao Zhang, Lei Shi, Fei Cao and Tianjiang Ma
    Citation: BMC Cancer 2018 18:847
    Content type: Research article Published on:

  32. Chronic inflammation and repeated infection with Opisthorchis viverrini (O. viverrini) induces intrahepatic cholangiocarcinoma (ICC). Inflammatory cytokines such as interleukin (IL) and tumor necrosis factor (TNF...

    Authors: Supannee Promthet, Nopparat Songserm, Somkiattiyos Woradet, Chamsai Pientong, Tipaya Ekalaksananan, Surapon Wiangnon and Akhtar Ali
    Citation: BMC Cancer 2018 18:846
    Content type: Research article Published on:

  33. Routine assessment and clinical utilisation of patient-reported outcome (PRO) measures can lead to improved patient outcomes. The PROMPT-Care eHealth system facilitates PRO data capture from cancer patients, d...

    Authors: Afaf Girgis, Ivana Durcinoska, Martha Gerges, Nasreen Kaadan, Anthony Arnold, Joseph Descallar and Geoff P. Delaney
    Citation: BMC Cancer 2018 18:845
    Content type: Study protocol Published on:

  34. The majority of patients undergoing hepatectomy for hepatocellular carcinoma (HCC) suffer from underlying liver disease and are exposed to the risk of postoperative ascites, which is favored by an imbalance be...

    Authors: Kayvan Mohkam, Michel Rayar, Jean-Philippe Adam, Fabrice Muscari, Agnès Rode, Philippe Merle, Pierre Pradat, Stéphanie Bauler, Isabelle Delfour, Laurence Chiche, Christian Ducerf, Karim Boudjema, Mickaël Lesurtel, Christophe Laurent and Jean-Yves Mabrut
    Citation: BMC Cancer 2018 18:844
    Content type: Study protocol Published on:

  36. High-grade spindle cell sarcomas are a subtype of rare, undifferentiated pleomorphic sarcomas (UPSs) for which diagnosis is difficult and no specific treatment strategies have been established. The limited pub...

    Authors: Ning Zhou, Reinhold Schäfer, Tao Li, Meiyu Fang and Luying Liu
    Citation: BMC Cancer 2018 18:842
    Content type: Case report Published on:

  37. An increase in naturally-occurring porphyrins has been described in the blood of subjects bearing different kinds of tumors, including colorectal, and this is probably related to a systemic alteration of heme ...

    Authors: Manuela Lualdi, Adalberto Cavalleri, Luigi Battaglia, Ambrogio Colombo, Giulia Garrone, Daniele Morelli, Emanuele Pignoli, Elisa Sottotetti and Ermanno Leo
    Citation: BMC Cancer 2018 18:841
    Content type: Research article Published on:

  38. Pleomorphic liposarcoma (PLPS) is a rare, heterogeneous and an aggressive variant of liposarcoma. Therefore, individualized therapy is urgently needed. Our recent reports suggest that trabectedin (TRAB) is eff...

    Authors: Tasuku Kiyuna, Yasunori Tome, Takashi Murakami, Kei Kawaguchi, Kentaro Igarashi, Kentaro Miyake, Masuyo Miyake, Yunfeng Li, Scott D. Nelson, Sarah M. Dry, Arun S. Singh, Tara A. Russell, Irmina Elliott, Shree Ram Singh, Fuminori Kanaya, Fritz C. Eilber…
    Citation: BMC Cancer 2018 18:840
    Content type: Research article Published on:

  39. Metastatic breast cancer (MBC) rest an incurably disease associated with bad prognosis and a median overall survival of 23–31 months. There are several treatment options including chemotherapy and sometimes en...

    Authors: Jean-David Fumet, Mark Wickre, Jean-Philippe Jacquot, Marie-Helene Bizollon, Adrien Melis, André Vanoli and Erika Viel
    Citation: BMC Cancer 2018 18:839
    Content type: Case report Published on:

  40. Nucleophosmin is a non-ribosomal nucleolar phosphoprotein that is found primarily in the nucleolus region of cell nucleus, plays multiple important roles in tumor processes. Accumulated previous studies have r...

    Authors: Siying Chen, Hairong He, Yan Wang, Leichao Liu, Yang Liu, Haisheng You, Yalin Dong and Jun Lyu
    Citation: BMC Cancer 2018 18:838
    Content type: Research article Published on:

  41. To evaluate the role of blood vascular endothelial growth factor (VEGF) kinetics in patients with locally advanced esophageal squamous cell carcinoma (ESCC) receiving curative concurrent chemoradiotherapy (CCRT).

    Authors: Yen-Hao Chen, Hung-I Lu, Chien-Ming Lo, Yu-Ming Wang, Shang-Yu Chou, Chang-Chun Hsiao, Chao-Cheng Huang, Li-Hsueh Shih, Su-Wei Chen and Shau-Hsuan Li
    Citation: BMC Cancer 2018 18:837
    Content type: Research article Published on:

  42. Oxidative stress induces various intracellular damage, which might be correlated with tumorigenesis. Accumulated oxidative stresses might inactivate protein tyrosine phosphatase (PTP) by oxidizing it, and indu...

    Authors: Usama Khamis Hussein, Ho Sung Park, Jun Sang Bae, Kyoung Min Kim, Yun Jo Chong, Chan Young Kim, Keun Sang Kwon, Myoung Ja Chung, Ho Lee, Myoung Jae Kang, Woo Sung Moon and Kyu Yun Jang
    Citation: BMC Cancer 2018 18:836
    Content type: Research article Published on:

  43. This study explored the effect of liver resection on perioperative circulating tumor cells (CTCs) and found that the prognostic significance of surgery was associated with changes in CTC counts in patients wit...

    Authors: Jing-jing Yu, Wei Xiao, Shui-lin Dong, Hui-fang Liang, Zhi-wei Zhang, Bi-xiang Zhang, Zhi-yong Huang, Yi-fa Chen, Wan-guang Zhang, Hong-ping Luo, Qian Chen and Xiao-ping Chen
    Citation: BMC Cancer 2018 18:835
    Content type: Research article Published on:

  44. Circular RNAs are a new class of endogenous non-coding RNA that can function as crucial regulators of diverse cellular processes. The diverse types of circular RNAs with varying cytogenetics in cancer have als...

    Authors: Zikang Zhang, Qing Xie, Dongmei He, Yuan Ling, Yuchao Li, Jiangbin Li and Hua Zhang
    Citation: BMC Cancer 2018 18:834
    Content type: Debate Published on:

  45. The aim of this study was to evaluate the early anti-tumor efficiency of different therapeutic agents with a combination of multi-b-value DWI, DCE-MRI and texture analysis.

    Authors: Ming Meng, Huadan Xue, Jing Lei, Qin Wang, Jingjuan Liu, Yuan Li, Ting Sun, Haiyan Xu and Zhengyu Jin
    Citation: BMC Cancer 2018 18:833
    Content type: Research article Published on:

  46. Breast (mammary) cancers in human (BC) and canine (CMT) patients share clinical, pathological, and molecular similarities that suggest dogs may be a useful translational model. Many cancers, including BC, shed...

    Authors: Eric J. Fish, Kristopher J. Irizarry, Patricia DeInnocentes, Connor J. Ellis, Nripesh Prasad, Anthony G. Moss and R. Curt Bird
    Citation: BMC Cancer 2018 18:832
    Content type: Research article Published on:

  48. Seroma formation is a common complication after mastectomy and is associated with delayed wound healing, infection, skin flap necrosis, patient discomfort and repeated visits to the out patient clinic to deal ...

    Authors: J. van Bastelaar, R. Granzier, L. M. van Roozendaal, G. Beets, C. D. Dirksen and Y. Vissers
    Citation: BMC Cancer 2018 18:830
    Content type: Study protocol Published on:

  49. Core needle biopsy (CNB) is a standard diagnostic procedure in the setting of breast cancer screening. However, CNB may result in the borderline diagnoses of lesion of uncertain malignant potential (B3). The a...

    Authors: Christiane Richter-Ehrenstein, Katharina Maak, Sonja Röger and Tilman Ehrenstein
    Citation: BMC Cancer 2018 18:829
    Content type: Research article Published on:

  50. Pneumatosis intestinalis (PI) is a rare complication of chemotherapy, characterized by multiple gas accumulations within the bowel wall.

    Authors: Hironori Uruga, Shuhei Moriguchi, Yui Takahashi, Kazumasa Ogawa, Kyoko Murase, Sayaka Mochizuki, Shigeo Hanada, Hisashi Takaya, Atsushi Miyamoto, Nasa Morokawa and Kazuma Kishi
    Citation: BMC Cancer 2018 18:825
    Content type: Case report Published on:

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