The TB interface gene signature does not resemble normal bone. A. Top genes differentially expressed at the TB interface common to all the three cell lines. Data are expressed in fold-change relative to TA area: (up-regulated genes (≥2-fold) are shown in red, and down-regulated genes (≤-2-fold) are shown in green. B. The NTP algorithm was used to predict whether normal calvarial bone, ulnar bone and mandiblular bone resemble the TB interface of our mouse osteoclastic model. Samples predicted with FDR p > 0.2 do not resemble either the TA area or the TB interface. Samples and prediction significance are shown on the top of the hierarchical cluster.