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Table 4 Incidence and frequency of PIN and tumors in mice treated with MNU + testosterone + estradiol

From: p27Kip1deficiency promotes prostate carcinogenesis but does not affect the efficacy of retinoids in suppressing the neoplastic process

Genotype 9cRA Animals-No PIN P Tumors*
No
   at start at end Incidence Frequency   
p27+/+ 0 20 15 13 0.13 ± 0.3   2
p27+/+ + 20 15 13 0.13 ± 0.3 ns 1
p27+/- 0 20 10 40 0.7 ± 0.3   4
p27+/- + 20 10 60 1.3 ± 1.1 ns 3
p27-/- 0 20 10 80 2.3 ± 1.2   5
p27-/- + 20 8 87 1.7 ± 1.0 ns 5
  1. Animals were implanted with a testosterone pellet at the age of 2 months and 6 days later MNU was injected ip to initiate the neoplastic process. Four days after carcinogen administration an estradiol pellet was sc implanted. %, incidence of tumors among control and treated animals; No: multiplicity of PIN per treated animal; ns, not significant (p > 0.05). To determine the incidence (%) and frequency of PIN in DLP, 4 μm thick longitudinally paraffin sections through the urethral part of the prostate were cut stepwise at three separate levels 30 μm apart.