p27Kip1deficiency promotes prostate carcinogenesis but does not affect the efficacy of retinoids in suppressing the neoplastic process

Table 2 Alteration in body weight and in DLP weight in the course of prostate carcinogenesis

Genotype	Body wt: (g) Placebo		Body wt. (g) 9cRA		DLP-(mg) Placebo	DLP-(mg) 9cRA
p27+/+	8	30.8 ± 4.3*	10	27.2 ± 5.4*	48.3 ± 13.1**	45.6 ± 7.7**
p27+/-	10	35.8 ± 5.1	12	31.3 ± 5.6	67.2 ± 14.5	60.2 ± 10.5
p27-/-	12	41.4 ± 5.6*	10	35.5 ± 6.4*	97.6 ± 21.0** x	80.5 ± 18.6** x

These are the final measurements of body weight (g) at the end of experiment when the animals were sacrificed. DLP was isolated at autopsy, measured on an analytical balance and then frozen or embedded in 10% neutral formalin. Body and DLP weights were higher in p27-/- as compared to p27+/+ mice; *, p < 0.01; **, 0.001. 9cRA also decreased DLP weight in p27-/- mice (x) as compared to placebo-treated mice (p < 0.02).

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