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Table 3 9cRA inhibits MNU-induced prostate carcinogenesis in p27 deficient mice

From: p27Kip1deficiency promotes prostate carcinogenesis but does not affect the efficacy of retinoids in suppressing the neoplastic process

    PIN P Tumors
Genotype Animals No 9cRA Incidence Frequency   P DO
p27+/+ 18 0 11 0.16 ± 0.5   0 0
p27+/+ 17 + 0 0 0 0 0
p27+/- 16 0 60 1.5 ± 0.5*   3 4
p27+/- 15 + 44 1.1 ± 0.6 0.05 2 4
p27-/- 15 0 70 2.0 ± 0.4*   3 6
p27-/- 15 + 53 1.4 ± 0.5 0.005 4 6
  1. Animals were treated with MNU, 30 mg/kg body weight at the age of 2 months and followed until sacrifice between 7-12 months of age. PIN were identified in DLP by cutting longitudinally through the urethral part of the prostate. H&E staining was used for identification of PIN. Stepwise, 4 μm thick paraffin sections at three separate tissue levels 30 μm apart were cut and the number of PIN per prostate determined. Incidence, percentage of animals with PIN per group; frequency, number of PIN per animal. PIN were determined in various groups without knowledge of the treatment protocol. (P), prostate; (DO), distant organs; *, significant difference (p < 0.01) in the multiplicity of PIN between p27+/- and p27-/- mice;