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Table 2 Pathways or functional groups of genes differentially expressed in tumours by GenMapp/MappFinder analysis*.

From: Gene expression profile and genomic alterations in colonic tumours induced by 1,2-dimethylhydrazine (DMH) in rats

MAPP Name

Number Changed

Number Measured

Number On MAPP

Z Score

Up-regulated pathways or functional group of genes

    

Rn_DNA_replication_Reactome

17

22

40

3.289

Rn_Matrix_Metalloproteinases

12

13

28

3.621

Rn_TNF-alpha-NF-kB_NetPath_9

69

117

159

3.648

Rn_G1_to_S_cell_cycle_Reactome

29

40

69

3.838

Rn_mRNA_processing_Reactome

44

66

125

3.988

Rn_Translation_Factors

24

29

40

4.383

Rn_Ribosomal_Proteins

65

74

81

7.979

Rn_Cell_cycle_KEGG

32

49

80

3.227

Rn_RNA_transcription_Reactome

15

19

41

3.202

Rn_TGF_Beta_Signaling_Pathway

27

39

45

3.372

Rn_Inflammatory_Response_Pathway

16

22

40

2.855

Rn_Proteasome_Degradation

27

42

53

2.848

Rn_Alpha6-Beta4-Integrin_NetPath_1

29

47

64

2.654

Rn_B_Cell_Receptor_NetPath_12

61

112

146

2.573

Rn_Signaling_of_Hepatocyte_Growth_Factor_Receptor_Biocarta

18

27

33

2.527

Rn_Nucleotide_Metabolism

10

14

17

2.175

Rn_Complement_Activation_Classical

7

9

14

2.127

Down-regulated pathways or functional group of genes

    

Rn_Nuclear_Receptors

16

26

37

3.564

Rn_Unsaturated_Fatty_Acid_Beta_Oxidation_BiGCaT

6

6

6

3.766

Rn_Electron_Transport_Chain

26

44

58

4.298

Rn_Nuclear_receptors_in_lipid_metabolism_and_toxicity

13

19

33

3.700

Rn_Fatty_Acid_Beta_Oxidation_2_BiGCaT

5

6

6

2.873

Rn_Krebs-TCA_Cycle

12

23

26

2.362

Rn_Irinotecan_pathway_PharmGKB

5

6

12

2.873

Rn_Peptide_GPCRs

15

31

62

2.283

Rn_Calcium_regulation_in_cardiac_cells

41

102

150

2.360

Rn_Glucocorticoid_Mineralocorticoid_Metabolism

5

7

9

2.414

  1. * Significantly enriched pathways (z-score >2) are listed. The different columns show the number of genes differentially expressed compared with normal mucosa, the number of genes analyzed and the number of genes listed in each map (http://www.genmapp.org; University of California at San Francisco, San Francisco, CA, USA)