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  1. Cimetidine, a histamine type-2 receptor antagonist, has been reported to inhibit the growth of glandular tumors such as colorectal cancer, however the mechanism of action underlying this effect is unknown. Ade...

    Authors: Masakatsu Fukuda, Kaoru Kusama and Hideaki Sakashita
    Citation: BMC Cancer 2008 8:376
    Content type: Research article Published on:

  2. Chemoresistance is one of the main obstacles to successful cancer therapy and is frequently associated with Multidrug resistance (MDR). Many different mechanisms have been suggested to explain the development ...

    Authors: Xianling Guo, Nannan Ma, Jin Wang, Jianrui Song, Xinxin Bu, Yue Cheng, Kai Sun, Haiyan Xiong, Guocheng Jiang, Baihe Zhang, Mengchao Wu and Lixin Wei
    Citation: BMC Cancer 2008 8:375
    Content type: Research article Published on:

  3. In a previous report we have demonstrated that the chymotryptic-like serine protease kallikrein 7 (KLK7/hK7) is overexpressed in pancreatic cancer. In normal skin, hK7 is thought to participate in skin desquamati...

    Authors: Vishnu C Ramani, Leah Hennings and Randy S Haun
    Citation: BMC Cancer 2008 8:373
    Content type: Research article Published on:

  4. Chemotherapy resistance remains a major obstacle for the treatment of small cell lung cancer (SCLC). Glucose-regulated protein 78 (GRP78), an endoplasmic reticulum chaperone, plays a critical role in chemother...

    Authors: Yingyan Wang, Wei Wang, Siyan Wang, Jiarui Wang, Shujuan Shao and Qi Wang
    Citation: BMC Cancer 2008 8:372
    Content type: Research article Published on:

  5. Cell lines are often poorly characterized from a genetic point of view, reducing their usefulness as tumor models. Our purpose was to assess the genetic background of eight commonly used human thyroid carcinom...

    Authors: Franclim Ricardo Ribeiro, Ana Margarida Meireles, Ana Sofia Rocha and Manuel Rodrigues Teixeira
    Citation: BMC Cancer 2008 8:371
    Content type: Research article Published on:

  6. Rejection of transplanted tumors by the immune system is a rare event in syngeneic hosts, and is considered to be dependent on the local interaction of defensive immune reactions and tumor tolerance mechanisms...

    Authors: Alexander Y Wagner, Eric Holle, Lori Holle, Xianzhong Yu and Günter Schwamberger
    Citation: BMC Cancer 2008 8:370
    Content type: Research article Published on:

  7. The three far-upstream element (FUSE) binding proteins (FBP1, FBP2, and FBP3) belong to an ancient family of single-stranded DNA binding proteins which are required for proper regulation of the c-myc proto-oncoge...

    Authors: Achim Weber, Ilka Kristiansen, Manfred Johannsen, Beibei Oelrich, Katharina Scholmann, Sven Gunia, Matthias May, Hellmuth-Alexander Meyer, Silvia Behnke, Holger Moch and Glen Kristiansen
    Citation: BMC Cancer 2008 8:369
    Content type: Research article Published on:

  8. From 1968 to 2002, Singapore experienced an almost four-fold increase in prostate cancer incidence. This paper examines the incidence, mortality and survival patterns for prostate cancer among all residents in...

    Authors: Sin Eng Chia, Chuen Seng Tan, Gek Hsiang Lim, Xueling Sim, Yudi Pawitan, Marie Reilly, Safiyya Mohamed Ali, Weber Lau and Kee Seng Chia
    Citation: BMC Cancer 2008 8:368
    Content type: Research article Published on:

  9. Several evidences suggested that ovarian cancer (OC) patients showing isolated lymph node recurrence (ILNR) have an indolent evolution. The aim of the study was to retrospectively review ILNR observed in our I...

    Authors: Francesco Legge, Marco Petrillo, Vincenzo Adamo, Salvatore Pisconti, Giovanni Scambia and Gabriella Ferrandina
    Citation: BMC Cancer 2008 8:367
    Content type: Research article Published on:

  10. The effects of vegetable preference and leisure-time physical activity (LPA) on cancer have been inconsistent. We examined the effects of dietary preference and physical activity, as well as their combined eff...

    Authors: Young Ho Yun, Min Kyung Lim, Young-Joo Won, Sang Min Park, Yoon Jung Chang, Sang Woo Oh and Soon Ae Shin
    Citation: BMC Cancer 2008 8:366
    Content type: Research article Published on:

  12. Carcinoma-associated fibroblasts (CAFs) can promote carcinogenesis and tumor progression. Only limited data on the response of CAFs to chemotherapy and their potential impact on therapy outcome are available. ...

    Authors: Maike Sonnenberg, Heiko van der Kuip, Silke Haubeiß, Peter Fritz, Werner Schroth, Godehard Friedel, Wolfgang Simon, Thomas E Mürdter and Walter E Aulitzky
    Citation: BMC Cancer 2008 8:364
    Content type: Research article Published on:

  13. The EGFR and HER2 genes are located on chromosomes 7 and 17, respectively. They are therapeutic targets in some tumors. The TOP2A gene, which is located near HER2 on chromosome 17, is the target of many chemot...

    Authors: Zhiyong Liang, Xuan Zeng, Jie Gao, Shafei Wu, Peng Wang, Xiaohua Shi, Jing Zhang and Tonghua Liu
    Citation: BMC Cancer 2008 8:363
    Content type: Research article Published on:

  14. Tumor necrosis and apoptotic activity are considered important in cancer progression, but these features have not been much studied in melanomas. Our hypothesis was that rapid growth in cutaneous melanomas of ...

    Authors: Ingeborg M Bachmann, Rita G Ladstein, Oddbjørn Straume, George N Naumov and Lars A Akslen
    Citation: BMC Cancer 2008 8:362
    Content type: Research article Published on:

  15. Advanced pancreatic cancer, in addition to its high mortality, is characterized by one of the highest rates of venous thromboembolic events (VTE) as compared to other types of cancer. Enoxaparin, a low molecul...

    Authors: Hanno Riess, Uwe Pelzer, Andreas Hilbig, Jens Stieler, Bernhard Opitz, Theo Scholten, Dörte Kauschat-Brüning, Peter Bramlage, Bernd Dörken and Helmut Oettle
    Citation: BMC Cancer 2008 8:361
    Content type: Study protocol Published on:

  16. Human cancer vaccines incorporating autologous tumor cells carry a risk of implantation and subsequent metastasis of viable tumor cells into the patient who is being treated. Despite the fact that the melanoma...

    Authors: Donna H Deacon, Kevin T Hogan, Erin M Swanson, Kimberly A Chianese-Bullock, Chadrick E Denlinger, Andrea R Czarkowski, Randy S Schrecengost, James W Patterson, Mark W Teague and Craig L Slingluff Jr
    Citation: BMC Cancer 2008 8:360
    Content type: Research article Published on:

  17. Human Epidermal Growth Factor Receptor 2 (HER-2; also known as erbB-2 or neu), a proto-oncogene of the receptor tyrosine kinase superfamily, has been associated with carcinogenesis and prognosis of human cance...

    Authors: Uk Hyun Jo, Sle Gi Lo Han, Jae Hong Seo, Kyong Hwa Park, Jae Won Lee, Hyo Jung Lee, Jeong Seon Ryu and Yeul Hong Kim
    Citation: BMC Cancer 2008 8:359
    Content type: Research article Published on:

  18. The main study objectives were: to establish a nationwide voluntary collaborative network of breast centres with independent data analysis; to define suitable quality indicators (QIs) for benchmarking the qual...

    Authors: Sara Y Brucker, Claudia Schumacher, Christoph Sohn, Mahdi Rezai, Michael Bamberg and Diethelm Wallwiener
    Citation: BMC Cancer 2008 8:358
    Content type: Research article Published on:

  19. The germline TP53-R337H mutation is strongly associated with pediatric adrenocortical tumors (ACT) in southern Brazil; it has low penetrance and limited tissue specificity in most families and therefore is not as...

    Authors: Juliana G Assumpção, Ana Luíza Seidinger, Maria José Mastellaro, Raul C Ribeiro, Gerard P Zambetti, Ramapriya Ganti, Kumar Srivastava, Sheila Shurtleff, Deqing Pei, Luiz Carlos Zeferino, Rozany M Dufloth, Silvia Regina Brandalise and José Andres Yunes
    Citation: BMC Cancer 2008 8:357
    Content type: Research article Published on:

  20. Recent reviews claiming smokeless tobacco increases pancreatic cancer risk appear not to have considered all available epidemiological evidence; nor were meta-analyses included. We present a systematic review ...

    Authors: Zheng Sponsiello-Wang, Rolf Weitkunat and Peter N Lee
    Citation: BMC Cancer 2008 8:356
    Content type: Research article Published on:

  21. Little is known about the effect of migrant status on childhood cancer survival. We studied cancer survival among children of Turkish descent in the German Cancer Childhood Registry, one of the largest childho...

    Authors: Claudia Spix, Jacob Spallek, Peter Kaatsch, Oliver Razum and Hajo Zeeb
    Citation: BMC Cancer 2008 8:355
    Content type: Research article Published on:

  23. Recepteur d'origine nantais (RON) is a receptor tyrosine kinase that is activated by a serum-derived, macrophage stimulating protein (MSP) growth factor and is expressed in many malignant tumors. The aim of th...

    Authors: Donghui Zhou, Gang Pan, Chen Zheng, Jingjing Zheng, Liping Yian and Xiaodong Teng
    Citation: BMC Cancer 2008 8:353
    Content type: Research article Published on:

  24. Pancreatic cancer continues to have a 5-year survival of less than 5%. Therefore, more effective therapies are necessary to improve prognosis in this disease. Angiogenesis is required for tumor growth, and sub...

    Authors: Sean P Dineen, Laura A Sullivan, Adam W Beck, Andrew F Miller, Juliet G Carbon, Roni Mamluk, Henry Wong and Rolf A Brekken
    Citation: BMC Cancer 2008 8:352
    Content type: Research article Published on:

  25. The objectives of this retrospective study was to evaluate the efficacy of stereotactic body radiation therapy (SBRT) for small non-resectable hepatocellular carcinoma (HCC) and SBRT combined with transarteria...

    Authors: Byung Ock Choi, Ihl Bohng Choi, Hong Seok Jang, Young Nam Kang, Ji Sun Jang, Si Hyun Bae, Seung Kew Yoon, Gyu Young Chai and Ki Mun Kang
    Citation: BMC Cancer 2008 8:351
    Content type: Research article Published on:

  26. Reference genes, which are often referred to as housekeeping genes are frequently used to normalize mRNA levels between different samples in quantitative reverse transcription polymerase chain reaction (qRT-PC...

    Authors: Vito R Cicinnati, Qingli Shen, Georgios C Sotiropoulos, Arnold Radtke, Guido Gerken and Susanne Beckebaum
    Citation: BMC Cancer 2008 8:350
    Content type: Research article Published on:

  27. Disease progression of hepatocellular cancer (HCC) in patients eligible for liver transplantation (LTx) occurs in up to 50% of patients, resulting in withdrawal from the LTx waiting list. Transarterial chemoem...

    Authors: K Hoffmann, H Glimm, B Radeleff, G Richter, C Heining, I Schenkel, A Zahlten-Hinguranage, P Schirrmacher, J Schmidt, MW Büchler, D Jaeger, C von Kalle and P Schemmer
    Citation: BMC Cancer 2008 8:349
    Content type: Study protocol Published on:

  28. Thymidylate synthase (TS) is an important target for chemotherapeutic treatment of cancer and high expression of TS has been associated with poor prognosis or refractory disease in several cancers including co...

    Authors: Takashi Shirasaki, Shin-ichiro Maruya, Hiroki Mizukami, Seiji Kakehata, Hidekachi Kurotaki, Soroku Yagihashi and Hideichi Shinkawa
    Citation: BMC Cancer 2008 8:348
    Content type: Research article Published on:

  29. Although K14E6 transgenic mice develop spontaneous tumors of the skin epithelium, no spontaneous reproductive tract malignancies arise, unless the transgenic mice were treated chronically with 17β-estradiol. T...

    Authors: D Mendoza-Villanueva, J Diaz-Chavez, L Uribe-Figueroa, C Rangel-Escareão, A Hidalgo-Miranda, S March-Mifsut, G Jimenez-Sanchez, PF Lambert and P Gariglio
    Citation: BMC Cancer 2008 8:347
    Content type: Research article Published on:

  30. Serous epithelial ovarian tumors can be subdivided into benign (BOV), low malignant potential (LMP) or borderline and invasive (TOV) tumors. Although the molecular characteristics of serous BOV, LMP and low gr...

    Authors: Véronique Ouellet, Tak Hay Ling, Karine Normandin, Jason Madore, Christian Lussier, Véronique Barrès, Dimcho Bachvarov, Claudine Rancourt, Patricia N Tonin, Diane M Provencher and Anne-Marie Mes-Masson
    Citation: BMC Cancer 2008 8:346
    Content type: Research article Published on:

  31. Stage at diagnosis plays a significant role in colorectal cancer (CRC) survival. Understanding which factors contribute to a more advanced stage at diagnosis is vital to improving overall survival. Comorbidity...

    Authors: S Yousuf Zafar, Amy P Abernethy, David H Abbott, Steven C Grambow, Jennifer E Marcello, James E Herndon II, Krista L Rowe, Jane T Kolimaga, Leah L Zullig, Meenal B Patwardhan and Dawn T Provenzale
    Citation: BMC Cancer 2008 8:345
    Content type: Research article Published on:

  32. Spatial clustering of different diseases has received much less attention than single disease mapping. Besides chance or artifact, clustering of different cancers in a given area may depend on exposure to a sh...

    Authors: Tiziana Cassetti, Francesco La Rosa, Luca Rossi, Daniela D'Alò and Fabrizio Stracci
    Citation: BMC Cancer 2008 8:344
    Content type: Research article Published on:

  33. Diagnosis and prognosis in breast cancer are mainly based on histology and immunohistochemistry of formalin-fixed, paraffin-embedded (FFPE) material. Recently, gene expression analysis was shown to elucidate t...

    Authors: Martina Schobesberger, Anna Baltzer, Andrea Oberli, Andreas Kappeler, Mathias Gugger, Hana Burger and Rolf Jaggi
    Citation: BMC Cancer 2008 8:343
    Content type: Technical advance Published on:

  34. Tripeptide tyroserleutide (YSL) is a novel small molecule anti-tumor polypeptide that has been shown to inhibit the growth of human liver cancer cells. In this study, we investigated the effects of YSL plus do...

    Authors: Zhi-feng Zhu, Li-juan Chen, Rong Lu, Jing Jia, Yu Liang, Qiong Xu, Chun-lei Zhou, Li Wang, Song Wang and Zhi Yao
    Citation: BMC Cancer 2008 8:342
    Content type: Research article Published on:

  35. Different methods exist to estimate smoking attributable cancer mortality rates (Peto and Ezzati methods, as examples). However, the smoking attributable estimates using these methods cannot be generalized to ...

    Authors: Bruce N Leistikow, Zubair Kabir, Gregory N Connolly, Luke Clancy and Hillel R Alpert
    Citation: BMC Cancer 2008 8:341
    Content type: Research article Published on:

  36. Lymph nodes constitute the first site of metastasis for most malignancies, and the extent of lymph node involvement is a major criterion for evaluating patient prognosis. The CXC chemokine receptor 4 (CXCR4) h...

    Authors: Hironao Yasuoka, Masahiko Tsujimoto, Katsuhide Yoshidome, Masaaki Nakahara, Rieko Kodama, Tokio Sanke and Yasushi Nakamura
    Citation: BMC Cancer 2008 8:340
    Content type: Research article Published on:

  37. Given the large number of genes purported to be prognostic for breast cancer, it would be optimal if the genes identified are not confounded by the continuously changing systemic therapies. The aim of this stu...

    Authors: Andrew Tutt, Alice Wang, Charles Rowland, Cheryl Gillett, Kit Lau, Karen Chew, Hongyue Dai, Shirley Kwok, Kenneth Ryder, Henry Shu, Robert Springall, Paul Cane, Blair McCallie, Lauren Kam-Morgan, Steve Anderson, Horst Buerger…
    Citation: BMC Cancer 2008 8:339
    Content type: Research article Published on:

  38. Leptin, a 16 kDa polypeptide hormone, implicated in various physiological processes, exerts its action through the leptin receptor, a member of the class I cytokine receptor family. Both leptin and leptin rece...

    Authors: Michael N Okobia, Clareann H Bunker, Seymour J Garte, Joseph M Zmuda, Emmanuel R Ezeome, Stanley N Anyanwu, Emmanuel E Uche, Lewis H Kuller, Robert E Ferrell and Emanuela Taioli
    Citation: BMC Cancer 2008 8:338
    Content type: Research article Published on:

  39. The Ras-dependent ERK1/2 MAP kinase signaling pathway plays a central role in cell proliferation control and is frequently activated in human colorectal cancer. Small-molecule inhibitors of MEK1/MEK2 are there...

    Authors: Laure Voisin, Catherine Julien, Stéphanie Duhamel, Kailesh Gopalbhai, Isabelle Claveau, Marc K Saba-El-Leil, Ian Gaël Rodrigue-Gervais, Louis Gaboury, Daniel Lamarre, Mark Basik and Sylvain Meloche
    Citation: BMC Cancer 2008 8:337
    Content type: Research article Published on:

  40. In Catalonia (Spain) breast cancer mortality has declined since the beginning of the 1990s. The dissemination of early detection by mammography and the introduction of adjuvant treatments are among the possibl...

    Authors: Montserrat Rue, Misericordia Carles, Ester Vilaprinyo, Montserrat Martinez-Alonso, Josep-Alfons Espinas, Roger Pla and Pilar Brugulat
    Citation: BMC Cancer 2008 8:336
    Content type: Research article Published on:

  41. The hypoxia-inducible factor (HIF) has emerged as an attractive target for cancer therapy. The few publications addressing the prognostic significance of Hypoxia-Inducible Factor 1α (HIF-1α) cellular expressio...

    Authors: Alexandros Daponte, Maria Ioannou, Ilias Mylonis, George Simos, Marcos Minas, Ioannis E Messinis and George Koukoulis
    Citation: BMC Cancer 2008 8:335
    Content type: Research article Published on:

  42. Endothelin(ET) axis plays a key role in many tumor progression and metastasis via various mechanisms such as angiogenesis, mediating extracellular matrix degradation and inhibition of apoptosis. However, there...

    Authors: Wenjie Jiao, Jing Xu, Jinsheng Zheng, Yi Shen, Lesheng Lin and Jian Li
    Citation: BMC Cancer 2008 8:334
    Content type: Research article Published on:

  43. Mucin alterations are a common feature of esophageal neoplasia, and alterations in MUC2 mucin have been associated with tumor progression in the esophagus. Bile acids have been linked to esophageal adenocarcin...

    Authors: JianTao Wu, Jun Gong, Juan Geng and YinXue Song
    Citation: BMC Cancer 2008 8:333
    Content type: Research article Published on:

  44. Recombinant granulocyte colony-stimulating factors (G-CSFs) such as Filgrastim are used to treat chemotherapy-induced neutropenia. We investigated a new G-CSF, XM02, and compared it to Neupogenâ„¢ after myelotox...

    Authors: A del Giglio, A Eniu, D Ganea-Motan, E Topuzov and H Lubenau
    Citation: BMC Cancer 2008 8:332
    Content type: Research article Published on:

  45. Breast cancer mortality has experienced important changes over the last century. Breast cancer occurs in the presence of other competing risks which can influence breast cancer incidence and mortality trends. ...

    Authors: Ester Vilaprinyo, Rosa Gispert, Montserrat Martínez-Alonso, Misericòrdia Carles, Roger Pla, Josep-Alfons Espinàs and Montserrat Rué
    Citation: BMC Cancer 2008 8:331
    Content type: Research article Published on:

  46. Measuring quality of life in breast cancer patients is of importance in assessing treatment outcomes. This study examined the impact of breast cancer diagnosis and its treatment on quality of life of women wit...

    Authors: Ali Montazeri, Mariam Vahdaninia, Iraj Harirchi, Mandana Ebrahimi, Fatemeh Khaleghi and Soghra Jarvandi
    Citation: BMC Cancer 2008 8:330
    Content type: Research article Published on:

  47. Protein tyrosine phosphatases (PTPs) like their antagonizing protein tyrosine kinases are key regulators of signal transduction thereby assuring normal control of cellular growth and differentiation. Increasin...

    Authors: Sebastian Korff, Stefan M Woerner, Yan P Yuan, Peer Bork, Magnus von Knebel Doeberitz and Johannes Gebert
    Citation: BMC Cancer 2008 8:329
    Content type: Research article Published on:

  48. A recent study has shown that phosphorylated c-Jun (p-c-Jun) interacts with TCF4 to form a complex that cooperatively enhances their transcriptional activity in the presence of β-Catenin, and that their intera...

    Authors: Kayoko Takeda, Ichiro Kinoshita, Yasushi Shimizu, Yusuke Ohba, Tomoo Itoh, Yoshihiro Matsuno, Toshiaki Shichinohe and Hirotoshi Dosaka-Akita
    Citation: BMC Cancer 2008 8:328
    Content type: Research article Published on:

  49. Previous results showed that over-expression of the WTH3 gene in MDR cells reduced MDR1 gene expression and converted their resistance to sensitivity to various anticancer drugs. In addition, the WTH3 gene promot...

    Authors: Kegui Tian, Yuezeng Wang, Yu Huang, Boqiao Sun, Yuxin Li and Haopeng Xu
    Citation: BMC Cancer 2008 8:327
    Content type: Research article Published on:

  50. Prognostic factors are defined as biological or clinical measurement associated with overall survival and/or disease-free survival. Previous studies have shown that patients with estrogen receptor (ER) positiv...

    Authors: Takayoshi Kiba, Takashi Inamoto, Tsutomu Nishimura, Masaya Ueno, Kazuhiro Yanagihara, Satoshi Teramukai, Hironori Kato, Masakazu Toi and Masanori Fukushima
    Citation: BMC Cancer 2008 8:323
    Content type: Research article Published on:

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