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  1. Stage at diagnosis plays a significant role in colorectal cancer (CRC) survival. Understanding which factors contribute to a more advanced stage at diagnosis is vital to improving overall survival. Comorbidity...

    Authors: S Yousuf Zafar, Amy P Abernethy, David H Abbott, Steven C Grambow, Jennifer E Marcello, James E Herndon II, Krista L Rowe, Jane T Kolimaga, Leah L Zullig, Meenal B Patwardhan and Dawn T Provenzale
    Citation: BMC Cancer 2008 8:345
  2. Diagnosis and prognosis in breast cancer are mainly based on histology and immunohistochemistry of formalin-fixed, paraffin-embedded (FFPE) material. Recently, gene expression analysis was shown to elucidate t...

    Authors: Martina Schobesberger, Anna Baltzer, Andrea Oberli, Andreas Kappeler, Mathias Gugger, Hana Burger and Rolf Jaggi
    Citation: BMC Cancer 2008 8:343
  3. Different methods exist to estimate smoking attributable cancer mortality rates (Peto and Ezzati methods, as examples). However, the smoking attributable estimates using these methods cannot be generalized to ...

    Authors: Bruce N Leistikow, Zubair Kabir, Gregory N Connolly, Luke Clancy and Hillel R Alpert
    Citation: BMC Cancer 2008 8:341
  4. Lymph nodes constitute the first site of metastasis for most malignancies, and the extent of lymph node involvement is a major criterion for evaluating patient prognosis. The CXC chemokine receptor 4 (CXCR4) h...

    Authors: Hironao Yasuoka, Masahiko Tsujimoto, Katsuhide Yoshidome, Masaaki Nakahara, Rieko Kodama, Tokio Sanke and Yasushi Nakamura
    Citation: BMC Cancer 2008 8:340
  5. Given the large number of genes purported to be prognostic for breast cancer, it would be optimal if the genes identified are not confounded by the continuously changing systemic therapies. The aim of this stu...

    Authors: Andrew Tutt, Alice Wang, Charles Rowland, Cheryl Gillett, Kit Lau, Karen Chew, Hongyue Dai, Shirley Kwok, Kenneth Ryder, Henry Shu, Robert Springall, Paul Cane, Blair McCallie, Lauren Kam-Morgan, Steve Anderson, Horst Buerger…
    Citation: BMC Cancer 2008 8:339
  6. Leptin, a 16 kDa polypeptide hormone, implicated in various physiological processes, exerts its action through the leptin receptor, a member of the class I cytokine receptor family. Both leptin and leptin rece...

    Authors: Michael N Okobia, Clareann H Bunker, Seymour J Garte, Joseph M Zmuda, Emmanuel R Ezeome, Stanley N Anyanwu, Emmanuel E Uche, Lewis H Kuller, Robert E Ferrell and Emanuela Taioli
    Citation: BMC Cancer 2008 8:338
  7. The Ras-dependent ERK1/2 MAP kinase signaling pathway plays a central role in cell proliferation control and is frequently activated in human colorectal cancer. Small-molecule inhibitors of MEK1/MEK2 are there...

    Authors: Laure Voisin, Catherine Julien, Stéphanie Duhamel, Kailesh Gopalbhai, Isabelle Claveau, Marc K Saba-El-Leil, Ian Gaël Rodrigue-Gervais, Louis Gaboury, Daniel Lamarre, Mark Basik and Sylvain Meloche
    Citation: BMC Cancer 2008 8:337
  8. In Catalonia (Spain) breast cancer mortality has declined since the beginning of the 1990s. The dissemination of early detection by mammography and the introduction of adjuvant treatments are among the possibl...

    Authors: Montserrat Rue, Misericordia Carles, Ester Vilaprinyo, Montserrat Martinez-Alonso, Josep-Alfons Espinas, Roger Pla and Pilar Brugulat
    Citation: BMC Cancer 2008 8:336
  9. The hypoxia-inducible factor (HIF) has emerged as an attractive target for cancer therapy. The few publications addressing the prognostic significance of Hypoxia-Inducible Factor 1α (HIF-1α) cellular expressio...

    Authors: Alexandros Daponte, Maria Ioannou, Ilias Mylonis, George Simos, Marcos Minas, Ioannis E Messinis and George Koukoulis
    Citation: BMC Cancer 2008 8:335
  10. Endothelin(ET) axis plays a key role in many tumor progression and metastasis via various mechanisms such as angiogenesis, mediating extracellular matrix degradation and inhibition of apoptosis. However, there...

    Authors: Wenjie Jiao, Jing Xu, Jinsheng Zheng, Yi Shen, Lesheng Lin and Jian Li
    Citation: BMC Cancer 2008 8:334
  11. Mucin alterations are a common feature of esophageal neoplasia, and alterations in MUC2 mucin have been associated with tumor progression in the esophagus. Bile acids have been linked to esophageal adenocarcin...

    Authors: JianTao Wu, Jun Gong, Juan Geng and YinXue Song
    Citation: BMC Cancer 2008 8:333
  12. Recombinant granulocyte colony-stimulating factors (G-CSFs) such as Filgrastim are used to treat chemotherapy-induced neutropenia. We investigated a new G-CSF, XM02, and compared it to Neupogen™ after myelotox...

    Authors: A del Giglio, A Eniu, D Ganea-Motan, E Topuzov and H Lubenau
    Citation: BMC Cancer 2008 8:332
  13. Breast cancer mortality has experienced important changes over the last century. Breast cancer occurs in the presence of other competing risks which can influence breast cancer incidence and mortality trends. ...

    Authors: Ester Vilaprinyo, Rosa Gispert, Montserrat Martínez-Alonso, Misericòrdia Carles, Roger Pla, Josep-Alfons Espinàs and Montserrat Rué
    Citation: BMC Cancer 2008 8:331
  14. Measuring quality of life in breast cancer patients is of importance in assessing treatment outcomes. This study examined the impact of breast cancer diagnosis and its treatment on quality of life of women wit...

    Authors: Ali Montazeri, Mariam Vahdaninia, Iraj Harirchi, Mandana Ebrahimi, Fatemeh Khaleghi and Soghra Jarvandi
    Citation: BMC Cancer 2008 8:330
  15. Protein tyrosine phosphatases (PTPs) like their antagonizing protein tyrosine kinases are key regulators of signal transduction thereby assuring normal control of cellular growth and differentiation. Increasin...

    Authors: Sebastian Korff, Stefan M Woerner, Yan P Yuan, Peer Bork, Magnus von Knebel Doeberitz and Johannes Gebert
    Citation: BMC Cancer 2008 8:329
  16. A recent study has shown that phosphorylated c-Jun (p-c-Jun) interacts with TCF4 to form a complex that cooperatively enhances their transcriptional activity in the presence of β-Catenin, and that their intera...

    Authors: Kayoko Takeda, Ichiro Kinoshita, Yasushi Shimizu, Yusuke Ohba, Tomoo Itoh, Yoshihiro Matsuno, Toshiaki Shichinohe and Hirotoshi Dosaka-Akita
    Citation: BMC Cancer 2008 8:328
  17. Previous results showed that over-expression of the WTH3 gene in MDR cells reduced MDR1 gene expression and converted their resistance to sensitivity to various anticancer drugs. In addition, the WTH3 gene promot...

    Authors: Kegui Tian, Yuezeng Wang, Yu Huang, Boqiao Sun, Yuxin Li and Haopeng Xu
    Citation: BMC Cancer 2008 8:327
  18. Sporadic colorectal cancers (CRC) are multifactorial diseases resulting from the combined effects of numerous genetic, environmental and behavioral risk factors. Genetic association studies have suggested low-...

    Authors: Sébastien Küry, Bruno Buecher, Sébastien Robiou-du-Pont, Catherine Scoul, Hélène Colman, Tanguy Le Neel, Claire Le Houérou, Roger Faroux, Jean Ollivry, Bernard Lafraise, Louis-Dominique Chupin, Véronique Sébille and Stéphane Bézieau
    Citation: BMC Cancer 2008 8:326
  19. Prognostic factors are defined as biological or clinical measurement associated with overall survival and/or disease-free survival. Previous studies have shown that patients with estrogen receptor (ER) positiv...

    Authors: Takayoshi Kiba, Takashi Inamoto, Tsutomu Nishimura, Masaya Ueno, Kazuhiro Yanagihara, Satoshi Teramukai, Hironori Kato, Masakazu Toi and Masanori Fukushima
    Citation: BMC Cancer 2008 8:323
  20. Estrogen is an established endometrial carcinogen. One of the most important mediators of estrogenic action is the estrogen receptor alpha. We have investigated whether polymorphic variation in the estrogen re...

    Authors: Sara Wedrén, Lovisa Lovmar, Keith Humphreys, Cecilia Magnusson, Håkan Melhus, Ann-Christine Syvänen, Andreas Kindmark, Ulf Landegren, Maria Lagerström Fermér, Fredrik Stiger, Ingemar Persson, John A Baron and Elisabete Weiderpass
    Citation: BMC Cancer 2008 8:322
  21. The relationship between Helicobacter pylori infection and pancreatic cancer has been investigated in three previous studies with contradictory results. The aim of the present study was to investigate the associa...

    Authors: Björn Lindkvist, Dorthe Johansen, Anders Borgström and Jonas Manjer
    Citation: BMC Cancer 2008 8:321
  22. Hypoxia-inducible factor 1 alpha (HIF-1α) is involved in processes promoting carcinogenesis of many tumors. However, its role in the development of colorectal cancer is unknown. To investigate the significance...

    Authors: Nektaria Simiantonaki, Marios Taxeidis, Caren Jayasinghe, Ursula Kurzik-Dumke and Charles James Kirkpatrick
    Citation: BMC Cancer 2008 8:320
  23. Granulosa cell tumours (GCTs) are frequently seen in menopausal women and are relatively indolent. Although the physiological properties of normal granulosa cells have been studied extensively, little is known...

    Authors: Misa Imai, Miho Muraki, Kiyoshi Takamatsu, Hidekazu Saito, Motoharu Seiki and Yuji Takahashi
    Citation: BMC Cancer 2008 8:319
  24. Anthracyclines and taxanes are commonly used in the treatment of breast cancer. However, tumor resistance to these drugs often develops, possibly due to overexpression of drug transporters. It remains unclear ...

    Authors: Stacey L Hembruff, Monique L Laberge, David J Villeneuve, Baoqing Guo, Zachary Veitch, Melanie Cecchetto and Amadeo M Parissenti
    Citation: BMC Cancer 2008 8:318
  25. Epidemiological studies suggested the chemopreventive role of higher calcium intake in colorectal carcinogenesis. We examined genetic polymorphisms that might influence calcium metabolism: lactase (LCT) gene 1...

    Authors: Krisztián Bácsi, Erika Hitre, János P Kósa, Henrik Horváth, Áron Lazáry, Péter L Lakatos, Bernadett Balla, Barna Budai, Péter Lakatos and Gábor Speer
    Citation: BMC Cancer 2008 8:317
  26. Epidemiological studies suggest that physical activity reduces the risk of colon cancer in humans. Results from animal studies, however, are inconclusive. The present study investigated the effects of voluntar...

    Authors: Jihyeung Ju, Bonnie Nolan, Michelle Cheh, Mousumi Bose, Yong Lin, George C Wagner and Chung S Yang
    Citation: BMC Cancer 2008 8:316
  27. Transcriptional profiling of prostate cancer (PC) has unveiled new markers of neoplasia and allowed insights into mechanisms underlying this disease. Genomewide analyses have also identified new chromosomal ab...

    Authors: Raquel Bermudo, David Abia, Berta Ferrer, Iracema Nayach, Alberto Benguria, Ángel Zaballos, Javier del Rey, Rosa Miró, Elías Campo, Carlos Martínez-A, Ángel R Ortiz, Pedro L Fernández and Timothy M Thomson
    Citation: BMC Cancer 2008 8:315
  28. Accurate staging of rectal tumors is essential for making the correct treatment choice. In a previous study, we found that loss of 17p, 18q and gain of 8q, 13q and 20q could distinguish adenoma from carcinoma ...

    Authors: Esther H Lips, Ronald van Eijk, Eelco JR de Graaf, Jan Oosting, Noel FCC de Miranda, Tom Karsten, Cornelis J van de Velde, Paul HC Eilers, Rob AEM Tollenaar, Tom van Wezel and Hans Morreau
    Citation: BMC Cancer 2008 8:314
  29. Doxorubicin is considered one of the most potent established chemotherapeutics in the treatment of liposarcoma; however, the response rates usually below 30%, are still disappointing. This study was performed ...

    Authors: Adrien Daigeler, Ludger Klein-Hitpass, Ansgar Michael Chromik, Oliver Müller, Jörg Hauser, Heinz-Herbert Homann, Hans-Ulrich Steinau and Marcus Lehnhardt
    Citation: BMC Cancer 2008 8:313
  30. Heat shock protein 90 (Hsp90) overexpression has been implicated in breast carcinogenesis, with putative prognostic and therapeutic implications. The purpose of this study is to evaluate the immunohistochemica...

    Authors: Flora Zagouri, Afrodite Nonni, Theodoros N Sergentanis, Christos A Papadimitriou, Nikolaos V Michalopoulos, Andreas C Lazaris, Efstratios Patsouris and George C Zografos
    Citation: BMC Cancer 2008 8:312
  31. The ageing of the population is expected to bring an enormous growth in demand for oncological health care. In order to anticipate and respond to future trends, cancer care needs to be critically evaluated. Th...

    Authors: Ron Pritzkuleit, Annika Waldmann, Heiner Raspe and Alexander Katalinic
    Citation: BMC Cancer 2008 8:311
  32. Lactic acid bacteria (LAB) are beneficial probiotic organisms that contribute to improved nutrition, microbial balance, and immuno-enhancement of the intestinal tract, as well as anti-tumor activity. The aim o...

    Authors: Do Kyung Lee, Seok Jang, Mi Jin Kim, Jung Hyun Kim, Myung Jun Chung, Kyung Jae Kim and Nam Joo Ha
    Citation: BMC Cancer 2008 8:310
  33. Triple-negative breast cancer (estrogen receptor-, progesterone receptor-, and HER2-negative) (TNBC) is a high risk breast cancer that lacks specific therapy targeting these proteins.

    Authors: Tatsuya Toyama, Hiroko Yamashita, Naoto Kondo, Katsuhiro Okuda, Satoru Takahashi, Hidefumi Sasaki, Hiroshi Sugiura, Hirotaka Iwase and Yoshitaka Fujii
    Citation: BMC Cancer 2008 8:309
  34. 14-3-3 sigma (σ) promotes G2/M cell cycle arrest by sequestering cyclin B1-CDC2 complex in cytoplasm. Down-regulation of 14-3-3σ, which has been demonstrated in various carcinomas, may contribute to malignant ...

    Authors: Zhihui Wang, Claes G Tropè, Zhenhe Suo, Gunhild Trøen, Guanrui Yang, Jahn M Nesland and Ruth Holm
    Citation: BMC Cancer 2008 8:308
  35. Triple-negative (TN) breast cancer, which is defined as being negative for the estrogen receptor (ER), the progesterone receptor (PR), and the human epidermal growth factor receptor 2 (HER-2), represents a sub...

    Authors: Jiyoung Rhee, Sae-Won Han, Do-Youn Oh, Jee Hyun Kim, Seock-Ah Im, Wonshik Han, In Ae Park, Dong-Young Noh, Yung-Jue Bang and Tae-You Kim
    Citation: BMC Cancer 2008 8:307
  36. Bone marrow-derived stromal cells (BMSCs) are important for development, tissue cell replenishment, and wound healing in physiological and pathological conditions. BMSCs were found to preferably reach sites un...

    Authors: M Hu, J-L Yang, H Teng, Y-Q Jia, R Wang, X-W Zhang, Y Wu, Y Luo, X-C Chen, R Zhang, L Tian, X Zhao and Y-Q Wei
    Citation: BMC Cancer 2008 8:306
  37. Obesity in postmenopausal women is associated with increased breast cancer risk, development of more aggressive tumors and resistance to certain anti-breast cancer treatments. Some of these effects might be me...

    Authors: Elena Fiorio, Anna Mercanti, Marianna Terrasi, Rocco Micciolo, Andrea Remo, Alessandra Auriemma, Annamaria Molino, Veronica Parolin, Bruno Di Stefano, Franco Bonetti, Antonio Giordano, Gian Luigi Cetto and Eva Surmacz
    Citation: BMC Cancer 2008 8:305
  38. Despite the advances made during decades of research, the mechanisms by which glioma is initiated and established remain elusive. The discovery of glioma stem cells (GSCs) may help to elucidate the processes o...

    Authors: Qiang Huang, Quan-Bin Zhang, Jun Dong, Yin-Yan Wu, Yun-Tian Shen, Yao-Dong Zhao, Yu-De Zhu, Yi Diao, Ai-Dong Wang and Qing Lan
    Citation: BMC Cancer 2008 8:304
  39. NDRG2 (N-Myc downstream-regulated gene 2) was initially cloned in our laboratory. Previous results have shown that NDRG2 expressed differentially in normal and cancer tissues. Specifically, NDRG2 mRNA was down-r...

    Authors: Huadong Zhao, Jian Zhang, Jianguo Lu, Xianli He, Changsheng Chen, Xiaojun Li, Li Gong, Guoqiang Bao, Qiang Fu, Suning Chen, Wei Lin, Hai Shi, Jianjun Ma, Xinping Liu, Qingjiu Ma and Libo Yao
    Citation: BMC Cancer 2008 8:303
  40. Many cancers, including breast cancer, have been identified with increased levels of phosphorylated or the active form of Signal Transducers and Activators of Transcription 3 (STAT3) protein. However, whether ...

    Authors: Jacqueline C Lieblein, Sarah Ball, Brian Hutzen, A Kate Sasser, Huey-Jen Lin, Tim HM Huang, Brett M Hall and Jiayuh Lin
    Citation: BMC Cancer 2008 8:302
  41. Protease activated receptor-2 (PAR-2) has been implicated in cellular proliferation, invasion and metastasis in various tumors. Lymph node metastasis is an important patient prognostic factor for uterine cervi...

    Authors: Israt Jahan, Jiro Fujimoto, Syed Mahfuzul Alam, Eriko Sato and Teruhiko Tamaya
    Citation: BMC Cancer 2008 8:301
  42. Nestin was originally identified as a class VI intermediate filament protein that is expressed in stem cells and progenitor cells in the mammalian CNS during development. This protein is replaced in the adult ...

    Authors: Renata Veselska, Marketa Hermanova, Tomas Loja, Petr Chlapek, Iva Zambo, Karel Vesely, Karel Zitterbart and Jaroslav Sterba
    Citation: BMC Cancer 2008 8:300
  43. Chronic myelomonocytic leukemia (CMML) is a hematological disease close to, but separate from both myeloproliferative disorders (MPD) and myelodysplastic syndromes and may show either myeloproliferative (MP-CM...

    Authors: Véronique Gelsi-Boyer, Virginie Trouplin, José Adélaïde, Nicola Aceto, Virginie Remy, Stephane Pinson, Claude Houdayer, Christine Arnoulet, Danielle Sainty, Mohamed Bentires-Alj, Sylviane Olschwang, Norbert Vey, Marie-Joëlle Mozziconacci, Daniel Birnbaum and Max Chaffanet
    Citation: BMC Cancer 2008 8:299
  44. While increased urokinase-type plasminogen activator (uPA) expression in breast cancer tissue is directly associated with poor prognosis, recent evidence suggests that uPA overexpression may suppress tumor gro...

    Authors: Wenyi Qin, Weizhu Zhu, John E Hewett, George Rottinghaus, Yin-Chieh Chen, John T Flynn, Beth Kliethermes, Ferdinando Mannello and Edward R Sauter
    Citation: BMC Cancer 2008 8:298
  45. Genomic alterations of the proto-oncogene c-erbB-2 (HER-2/neu) are associated with aggressive behavior and poor prognosis in patients with breast cancer. The variable clinical outcomes seen in patients with si...

    Authors: Rachel E Ellsworth, Darrell L Ellsworth, Heather L Patney, Brenda Deyarmin, Brad Love, Jeffrey A Hooke and Craig D Shriver
    Citation: BMC Cancer 2008 8:297
  46. Papillary thyroid microcarcinoma (PTMC) is defined as a papillary thyroid carcinoma less than or equal to 1.0 cm in size. Independent prognostic factors for clinical recurrence of PTMC have not been clearly de...

    Authors: Tae Yong Kim, Suck Joon Hong, Jung Min Kim, Won Gu Kim, Gyungyub Gong, Jin Sook Ryu, Won Bae Kim, Sung-Cheol Yun and Young Kee Shong
    Citation: BMC Cancer 2008 8:296
  47. The prediction of response to treatment would be valuable for managing cervical carcinoma with neoadjuvant chemotherapy.

    Authors: Chel Hun Choi, Sang Yong Song, Jung-Joo Choi, Young Ae Park, Heeseok Kang, Tae-Joong Kim, Jeong-Won Lee, Byoung-Gie Kim, Je-Ho Lee and Duk-Soo Bae
    Citation: BMC Cancer 2008 8:295

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