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  1. The treatment of high-risk neuroblastoma patients consists of multimodal induction therapy to achieve remission followed by consolidation therapy to prevent relapses. However, the type of consolidation therapy...

    Authors: Thorsten Simon, Barbara Hero, Andreas Faldum, Rupert Handgretinger, Martin Schrappe, Thomas Klingebiel and Frank Berthold
    Citation: BMC Cancer 2011 11:21
    Content type: Research article Published on:

  2. Metformin protection against cancer risk in Orientals is uncertain. We examined the possible metformin effect on total, esophageal, gastric, colorectal (CRC), hepatocellular (HCC) and pancreatic cancers in a T...

    Authors: Meei-Shyuan Lee, Chih-Cheng Hsu, Mark L Wahlqvist, Hsin-Ni Tsai, Yu-Hung Chang and Yi-Chen Huang
    Citation: BMC Cancer 2011 11:20
    Content type: Research article Published on:

  3. Many cancer patients seek homeopathy as a complementary therapy. It has rarely been studied systematically, whether homeopathic care is of benefit for cancer patients.

    Authors: Matthias Rostock, Johannes Naumann, Corina Guethlin, Lars Guenther, Hans H Bartsch and Harald Walach
    Citation: BMC Cancer 2011 11:19
    Content type: Research article Published on:

  4. Sentinel node (SN) biopsy has been practiced in gastric cancer in recent years, and many studies focused on the distribution of solitary lymph node metastasis (SLM) to assess the pattern of SN. In fact, there ...

    Authors: Baojun Huang, Zhenning Wang, Zhe Sun, Bo Zhao and Huimian Xu
    Citation: BMC Cancer 2011 11:18
    Content type: Research article Published on:

  5. "High risk" Human Papillomavirus strains are the causative agents of the vast majority of carcinomas of the uterine cervix. In these tumors, the physical integration of the HPV genome is a frequent, though not...

    Authors: Luisa Accardi, Maria Gabriella Donà, Anna M Mileo, Marco G Paggi, Antonio Federico, Paola Torreri, Tamara C Petrucci, Rosita Accardi, David Pim, Massimo Tommasino, Lawrence Banks, Barbara Chirullo and Colomba Giorgi
    Citation: BMC Cancer 2011 11:17
    Content type: Research article Published on:

  6. Local pelvic recurrence after radical cystectomy for muscle invasive bilharzial related squamous cell carcinoma accounts for 75% of treatment failures even in organ confined tumors. Despite the proven value of...

    Authors: Ahmad M Abdel Raheem, Diaa A Hameed, Ehab O ElGanainy, Eman Mosad, Mostafa E Abdelwanis, Nermen A Kamel, Hisham M Hammouda, Mohammad A Abdelaziz and Khaled Hemeyda
    Citation: BMC Cancer 2011 11:16
    Content type: Research article Published on:

  7. Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to conventional chemotherapy, in part due to the overexpression of inhibitors of apoptosis proteins (IAPs). Smac is an endogenous IAP-antagonist, whi...

    Authors: Niranjan Awasthi, Amanda Kirane, Margaret A Schwarz, Jason E Toombs, Rolf A Brekken and Roderich E Schwarz
    Citation: BMC Cancer 2011 11:15
    Content type: Research article Published on:

  8. Several studies have shown that NDRG2 mRNA is down-regulated or undetectable in various human cancers and cancer cell-lines. Although the function of NDRG2 is currently unknown, high NDRG2 expression correlates w...

    Authors: Anders Lorentzen, Rikke H Lewinsky, Jette Bornholdt, Lotte K Vogel and Cathy Mitchelmore
    Citation: BMC Cancer 2011 11:14
    Content type: Research article Published on:

  9. Authors: Yoon-La Choi, Ensel Oh, Sarah Park, Yeonju Kim, Yeon-Hee Park, Kyug Song, Eun Yoon Cho, Yun-Chul Hong, Jong Sun Choi, Jeong Eon Lee, Jung Han Kim, Seok Jin Nam, Young-Hyuck Lim, Jung-Hyun Yang and Young Kee Shin
    Citation: BMC Cancer 2011 11:13
    Content type: Erratum Published on:

    The original article was published in BMC Cancer 2010 10:507

  10. Carbonic anhydrase IX (CAIX) is a membranous expressed metalloenzyme involved in pH homeostasis and cell adhesion. The protein is overexpressed in a variety of tumors and potentially associated with negative o...

    Authors: Linn Woelber, Kerstin Kress, Jan F Kersten, Matthias Choschzick, Ergin Kilic, Uwe Herwig, Christoph Lindner, Joerg Schwarz, Fritz Jaenicke, Sven Mahner, Karin Milde-Langosch, Volkmar Mueller and Maike Ihnen
    Citation: BMC Cancer 2011 11:12
    Content type: Research article Published on:

  11. Mounting evidence has indicated that ABI3 (ABI family member 3) function as a tumor suppressor gene, although the molecular mechanism by which ABI3 acts remains largely unknown.

    Authors: Flavia RM Latini, Jefferson P Hemerly, Beatriz CG Freitas, Gisele Oler, Gregory J Riggins and Janete M Cerutti
    Citation: BMC Cancer 2011 11:11
    Content type: Research article Published on:

  12. Lymph node metastasis (LNM) of gastric cancer is an important prognostic factor regarding long-term survival. But several imaging techniques which are commonly used in stomach cannot satisfactorily assess the ...

    Authors: Xiao-Peng Zhang, Zhi-Long Wang, Lei Tang, Ying-Shi Sun, Kun Cao and Yun Gao
    Citation: BMC Cancer 2011 11:10
    Content type: Research article Published on:

  13. Ribonucleases are promising agents for use in anticancer therapy. Among the different ribonucleases described to be cytotoxic, a paradigmatic example is onconase which manifests cytotoxic and cytostatic effect...

    Authors: Jessica Castro, Marc Ribó, Susanna Navarro, Maria Victòria Nogués, Maria Vilanova and Antoni Benito
    Citation: BMC Cancer 2011 11:9
    Content type: Research article Published on:

  15. The extracellular signal-regulated kinase-1 and 2 (ERK1/2) proteins play an important role in cancer cell proliferation and survival. ERK1/2 proteins also are important for normal cell functions. Thus, anti-ca...

    Authors: Sarice R Boston, Rahul Deshmukh, Scott Strome, U Deva Priyakumar, Alexander D MacKerell Jr and Paul Shapiro
    Citation: BMC Cancer 2011 11:7
    Content type: Research article Published on:

  16. It has been estimated that between 5% and 10% of women diagnosed with breast cancer have a hereditary form of the disease, primarily caused by a BRCA1 or BRCA2 gene mutation. Such women have an increased risk of ...

    Authors: Marijke R Wevers, Margreet GEM Ausems, Senno Verhoef, Eveline MA Bleiker, Daniela EE Hahn, Frans BL Hogervorst, Rob B van der Luijt, Heiddis B Valdimarsdottir, Richard van Hillegersberg, Emiel JTh Rutgers and Neil K Aaronson
    Citation: BMC Cancer 2011 11:6
    Content type: Study protocol Published on:

  17. A number of studies have identified advanced age as a barrier to accessing specialised oncological care. Many factors can influence the care provided for elderly patients after a diagnosis of cancer has been e...

    Authors: Fleur Delva, Emilie Marien, Marianne Fonck, Muriel Rainfray, Jean-Louis Demeaux, Philippe Moreaud, Pierre Soubeyran, Annie J Sasco and Simone Mathoulin-Pélissier
    Citation: BMC Cancer 2011 11:5
    Content type: Research article Published on:

  18. As cell-free circulating DNA exists predominantly as mono- and oligonucleosomes, the focus of the current study was to examine the interplay of circulating nucleosomes, DNA, proteases and caspases in blood of ...

    Authors: Carina Roth, Klaus Pantel, Volkmar Müller, Brigitte Rack, Sabine Kasimir-Bauer, Wolfgang Janni and Heidi Schwarzenbach
    Citation: BMC Cancer 2011 11:4
    Content type: Research article Published on:

  19. Runt-related transcription factor 3 (RUNX3) is known as a tumor suppressor gene for gastric cancer and other cancers, this gene may be involved in the development of hepatocellular carcinoma (HCC).

    Authors: Yutaka Nakanishi, Hidenori Shiraha, Shin-ichi Nishina, Shigetomi Tanaka, Minoru Matsubara, Shigeru Horiguchi, Masaya Iwamuro, Nobuyuki Takaoka, Masayuki Uemura, Kenji Kuwaki, Hiroaki Hagihara, Junichi Toshimori, Hideki Ohnishi, Akinobu Takaki, Shinichiro Nakamura, Yoshiyuki Kobayashi…
    Citation: BMC Cancer 2011 11:3
    Content type: Research article Published on:

  20. Adequate nodal harvest (≥ 12 lymph nodes) in colorectal cancer has been shown to optimize staging and proposed as a quality indicator of colorectal cancer care. An audit within a single health district in Nova...

    Authors: Geoffrey A Porter, Robin Urquhart, Jingyu Bu, Paul Johnson and Eva Grunfeld
    Citation: BMC Cancer 2011 11:2
    Content type: Research article Published on:

  21. Gefitinib was the first epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) approved for the treatment of advanced non-small cell lung cancer (NSCLC). Few treatment options are available for ...

    Authors: Satoshi Watanabe, Junta Tanaka, Takeshi Ota, Rie Kondo, Hiroshi Tanaka, Hiroshi Kagamu, Kosuke Ichikawa, Jun Koshio, Junko Baba, Takao Miyabayashi, Ichiei Narita and Hirohisa Yoshizawa
    Citation: BMC Cancer 2011 11:1
    Content type: Research article Published on:

  22. In the setting of recurrent events, research studies commonly count only the first occurrence of an outcome in a subject. However this approach does not correctly reflect the natural history of the disease. Th...

    Authors: Virginie Rondeau, Simone Mathoulin-Pélissier, Lucie Tanneau, Annie J Sasco, Gaétan MacGrogan and Marc Debled
    Citation: BMC Cancer 2010 10:697
    Content type: Research article Published on:

  23. Stereotactic body radiation therapy (SBRT) applied by helical tomotherapy (HT) is feasible for lung cancer in clinical. Using SBRT concurrently with erlotinib for non-small cell lung cancer (NSCLC) is not repo...

    Authors: Chen-Hsi Hsieh, Hou-Tai Chang, Shih-Chiang Lin, Yu-Jen Chen, Li-Ying Wang, Yen-Ping Hsieh, Chien-An Chen, Ngot-Swan Chong, Shoei Long Lin, Chun-Yi Chen and Pei-Wei Shueng
    Citation: BMC Cancer 2010 10:696
    Content type: Case report Published on:

  24. Tyrosine kinase inhibitors (TKI) have enriched the therapeutic options in patients with renal cell carcinoma (RCC), which frequently induce morphological changes in tumors. However, only little is known about ...

    Authors: Viktor Gruenwald, Gernot Beutel, Susanne Schuch-Jantsch, Christoph Reuter, Philipp Ivanyi, Arnold Ganser and Marion Haubitz
    Citation: BMC Cancer 2010 10:695
    Content type: Research article Published on:

  25. iASPP is a key inhibitor of tumour suppressor p53 and is found to be up-regulated in certain malignant conditions. The present study investigated the expression of iASPP in clinical lung cancer, a leading canc...

    Authors: Jinfeng Chen, Fei Xie, Lijian Zhang and Wen G Jiang
    Citation: BMC Cancer 2010 10:694
    Content type: Research article Published on:

  27. Dexamethasone has been reported to reduce postoperative symptoms after different surgical procedures. We evaluated the efficacy of preoperative dexamethasone in ameliorating postoperative nausea and vomiting (...

    Authors: Jorge Gómez-Hernández, Alba Lorena Orozco-Alatorre, Marisela Domínguez-Contreras, Antonio Oceguera-Villanueva, Salvador Gómez-Romo, Andrea Socorro Alvarez Villaseñor, Clotilde Fuentes-Orozco and Alejandro González-Ojeda
    Citation: BMC Cancer 2010 10:692
    Content type: Research article Published on:

  28. The Oncotype DX® Colon Cancer Assay is a new diagnostic test for determining the likelihood of recurrence in stage II colon cancer patients after surgical resection using fixed paraffin embedded (FPE) primary col...

    Authors: Kim M Clark-Langone, Chithra Sangli, Jayadevi Krishnakumar and Drew Watson
    Citation: BMC Cancer 2010 10:691
    Content type: Technical advance Published on:

  29. The amino-acid balance in cancer patients often differs from that in healthy individuals, because of metabolic changes. This study investigated the use of plasma amino-acid profiles as a novel marker for scree...

    Authors: Jun Maeda, Masahiko Higashiyama, Akira Imaizumi, Tomio Nakayama, Hiroshi Yamamoto, Takashi Daimon, Minoru Yamakado, Fumio Imamura and Ken Kodama
    Citation: BMC Cancer 2010 10:690
    Content type: Research article Published on:

  30. We evaluate the long-term survival of patients with peritoneal carcinomatosis (PC) treated with systemic chemotherapy regimens, and the impact of the of the retrospective peritoneal disease severity score (PSD...

    Authors: Joerg OW Pelz, Terence C Chua, Jesus Esquivel, Alexander Stojadinovic, Joerg Doerfer, David L Morris, Uwe Maeder, Christoph-Thomas Germer and Alexander G Kerscher
    Citation: BMC Cancer 2010 10:689
    Content type: Research article Published on:

  31. Old age at diagnosis is associated with poor survival in colorectal cancer (CRC) for unknown reasons. Recent data show that colonoscopy is efficient in preventing left-sided cancers only. We examine the associ...

    Authors: Kari Hemminki, Irene Santi, Marianne Weires, Hauke Thomsen, Jan Sundquist and Justo Lorenzo Bermejo
    Citation: BMC Cancer 2010 10:688
    Content type: Research article Published on:

  32. To date, there are no clinically reliable predictive markers of response to the current treatment regimens for advanced colorectal cancer. The aim of the current study was to compare and assess the power of tr...

    Authors: Wendy L Allen, Puthen V Jithesh, Gavin R Oliver, Irina Proutski, Daniel B Longley, Heinz-Josef Lenz, Vitali Proutski, Paul Harkin and Patrick G Johnston
    Citation: BMC Cancer 2010 10:687
    Content type: Research article Published on:

  33. Polycomb Group (PcG) proteins are epigenetic silencers involved in maintaining cellular identity, and their deregulation can result in cancer. Expression of Mel-18 and Bmi-1 has been studied in tumor tissue, b...

    Authors: Margit LH Riis, Torben Lüders, Anne-Jorunn Nesbakken, Hilde S Vollan, Vessela Kristensen and Ida RK Bukholm
    Citation: BMC Cancer 2010 10:686
    Content type: Research article Published on:

  34. Oral leukoplakia (OL) is the best-known potentially malignant disorder. A new binary system to grade dysplasia was proposed by WHO, but the biological significance in predicting malignant transformation risk i...

    Authors: Wei Liu, Yu-Feng Wang, Hai-Wei Zhou, Peng Shi, Zeng-Tong Zhou and Guo-Yao Tang
    Citation: BMC Cancer 2010 10:685
    Content type: Research article Published on:

  35. Differentiation therapy has been shown effective in treatment of several types of cancer cells and may prove to be effective in treatment of glioblastoma multiforme, the most common and most aggressive primary...

    Authors: Xijun Liu, Jin-Ming Yang, Samuel S Zhang, Xin-Yuan Liu and David X Liu
    Citation: BMC Cancer 2010 10:684
    Content type: Research article Published on:

  36. Targeting tumor vasculature is a strategy with great promise in the treatment of many cancers. However, anti-angiogenic reagents that target VEGF/VEGFR2 signaling have met with variable results clinically. Amo...

    Authors: Steven G Patten, Una Adamcic, Kristen Lacombe, Kanwal Minhas, Karolina Skowronski and Brenda L Coomber
    Citation: BMC Cancer 2010 10:683
    Content type: Research article Published on:

  37. Gene expression of peripheral myelin protein 22 (PMP22) and the epithelial membrane proteins (EMPs) was found to be differentially expressed in invasive and non-invasive breast cell lines in a previous study. We ...

    Authors: Dan Tong, Georg Heinze, Dietmar Pils, Andrea Wolf, Christian F Singer, Nicole Concin, Gerda Hofstetter, Ingrid Schiebel, Margaretha Rudas and Robert Zeillinger
    Citation: BMC Cancer 2010 10:682
    Content type: Research article Published on:

  38. Stable disease (SD) has ambiguous clinical significance for patients according to the dominant Response Evaluation Criteria in Solid Tumours (RECIST). The primary aims of the study were: (1) to clarify the cli...

    Authors: Lijie He, Yuee Teng, Bo Jin, Mingfang Zhao, Ping Yu, Xuejun Hu, Jingdong Zhang, Songbai Li, Yaling Gao and Yunpeng Liu
    Citation: BMC Cancer 2010 10:681
    Content type: Research article Published on:

  39. The protein AGR2 is a putative member of the protein disulfide isomerase family and was first identified as a homolog of the Xenopus laevis gene XAG-2. AGR2 has been implicated in a number of human cancers. In pa...

    Authors: Erin L Maresh, Vei Mah, Mohammad Alavi, Steve Horvath, Lora Bagryanova, Emily S Liebeskind, Laura A Knutzen, Yong Zhou, David Chia, Alvin Y Liu and Lee Goodglick
    Citation: BMC Cancer 2010 10:680
    Content type: Research article Published on:

  40. The pharmacotherapeutic treatment of patients with cancer is generally associated with multiple side-effects. Drug interactions and duplicate prescriptions between anti-cancer drugs or interactions with medica...

    Authors: Roelof WF van Leeuwen, Eleonora L Swart, Frits A Boom, Martin S Schuitenmaker and Jacqueline G Hugtenburg
    Citation: BMC Cancer 2010 10:679
    Content type: Study protocol Published on:

  41. Prolactin is a polypeptide hormone responsible for proliferation and differentiation of the mammary gland. More recently, prolactin's role in mammary carcinogenesis has been studied with greater interest. Stud...

    Authors: Erika Ginsburg, Stefanie Alexander, Sarah Lieber, Sarah Tarplin, Luwanda Jenkins, Linda Pang, Christopher D Heger, Paul Goldsmith and Barbara K Vonderhaar
    Citation: BMC Cancer 2010 10:678
    Content type: Research article Published on:

  42. Inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) are promising cancer drugs currently in clinical trials in oncology, including APO866, CHS-828 and the CHS-828 prodrug EB1627/GMX1777, but cancer ce...

    Authors: Uffe H Olesen, Jakob G Petersen, Antje Garten, Wieland Kiess, Jun Yoshino, Shin-Ichiro Imai, Mette K Christensen, Peter Fristrup, Annemette V Thougaard, Fredrik Björkling, Peter B Jensen, Søren J Nielsen and Maxwell Sehested
    Citation: BMC Cancer 2010 10:677
    Content type: Research article Published on:

  43. Hedgehog (HH) signaling is critical for the expansion of granule neuron precursors (GNPs) within the external granular layer (EGL) during cerebellar development. Aberrant HH signaling within GNPs is thought to...

    Authors: Joseph R Cohen, Daniel Z Resnick, Pawel Niewiadomski, Hongmei Dong, Linda M Liau and James A Waschek
    Citation: BMC Cancer 2010 10:676
    Content type: Research article Published on:

  44. Hormone therapy plus radiotherapy significantly decreases recurrences and mortality of patients affected by locally advanced prostate cancer. In order to determine if difference exists according to the hormona...

    Authors: Federica Cuppone, Emilio Bria, Diana Giannarelli, Vanja Vaccaro, Michele Milella, Cecilia Nisticò, Enzo Maria Ruggeri, Isabella Sperduti, Sergio Bracarda, Paola Pinnarò, Gaetano Lanzetta, Paola Muti, Francesco Cognetti and Paolo Carlini
    Citation: BMC Cancer 2010 10:675
    Content type: Research article Published on:

  46. Cancer chemotherapy is frequently associated with a decline in general physical condition, exercise tolerance, and muscle strength and with an increase in fatigue. While accumulating evidence suggests that phy...

    Authors: Hanna van Waart, Martijn M Stuiver, Wim H van Harten, Gabe S Sonke and Neil K Aaronson
    Citation: BMC Cancer 2010 10:673
    Content type: Study protocol Published on:

  47. Aldo-keto reductase (AKR) 1C family member 3 (AKR1C3), one of four identified human AKR1C enzymes, catalyzes steroid, prostaglandin, and xenobiotic metabolism. In the prostate, AKR1C3 is up-regulated in locali...

    Authors: Mikhail G Dozmorov, Joseph T Azzarello, Jonathan D Wren, Kar-Ming Fung, Qing Yang, Jeffrey S Davis, Robert E Hurst, Daniel J Culkin, Trevor M Penning and Hsueh-Kung Lin
    Citation: BMC Cancer 2010 10:672
    Content type: Research article Published on:

  48. The use of high-dose chemotherapy combined with autologous stem cell transplantation has improved the outcome of hematologic malignancies. Nevertheless, this treatment can cause persistent fatigue and a reduce...

    Authors: Saskia Persoon, Marie José Kersten, Mai JM ChinAPaw, Laurien M Buffart, Heleen Burghout, Goof Schep, Johannes Brug and Frans Nollet
    Citation: BMC Cancer 2010 10:671
    Content type: Study protocol Published on:

  49. Genome-wide association studies and subsequent replication studies have shown that single nucleotide polymorphisms (SNPs) in the chromosomal region 8q24 are associated with colorectal cancer susceptibility.

    Authors: Carolyn M Hutter, Martha L Slattery, David J Duggan, Jill Muehling, Karen Curtin, Li Hsu, Shirley AA Beresford, Aleksandar Rajkovic, Gloria E Sarto, James R Marshall, Nazik Hammad, Robert Wallace, Karen W Makar, Ross L Prentice, Bette J Caan, John D Potter…
    Citation: BMC Cancer 2010 10:670
    Content type: Research article Published on:

  50. In this era of molecular targeting therapy when various systematic treatments can be selected, prognostic biomarkers are required for the purpose of risk-directed therapy selection. Numerous reports of various...

    Authors: Kazuhiro Namura, Ryogo Minamimoto, Masahiro Yao, Kazuhide Makiyama, Takayuki Murakami, Futoshi Sano, Narihiko Hayashi, Ukihide Tateishi, Hanako Ishigaki, Takeshi Kishida, Takeshi Miura, Kazuki Kobayashi, Sumio Noguchi, Tomio Inoue, Yoshinobu Kubota and Noboru Nakaigawa
    Citation: BMC Cancer 2010 10:667
    Content type: Research article Published on:

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