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  1. Novel ADC drugs provide a new therapeutic strategy for gastric cancer.The present study aimed to analyze the clinical efficacy and drug toxicities of disitamab vedotin (RC48) plus immune checkpoint inhibitors(...

    Authors: Caiyun Nie, Weifeng Xu, Yanwei Guo, Xiaohui Gao, Huifang Lv, Beibei Chen, Jianzheng Wang, Yingjun Liu, Jing Zhao, Saiqi Wang, Yunduan He and Xiaobing Chen
    Citation: BMC Cancer 2023 23:1239
    Content type: Research Published on:

  2. Previous metabolic studies in upper digestive cancer have mostly been limited to cross-sectional study designs, which hinders the ability to effectively predict outcomes in the early stage of cancer. This stud...

    Authors: Jiajing Che, Yongbin Zhao, Bingbing Gu, Shuting Li, Yunfei Li, Keyu Pan, Tiantian Sun, Xinyue Han, Jiali Lv, Shuai Zhang, Bingbing Fan, Chunxia Li, Cheng Wang, Jialin Wang and Tao Zhang
    Citation: BMC Cancer 2023 23:1238
    Content type: Research Published on:

  3. The promising therapeutic outcomes of neoadjuvant immunotherapy combined with chemotherapy in the treatment of locally advanced esophageal squamous cell carcinoma (ESCC) have been confirmed by several phase II...

    Authors: Chengzhi Ding, Yijun Guo, Yaning zhou, Yi He, Chunji Chen, Ming Zhang and Xufeng Guo
    Citation: BMC Cancer 2023 23:1237
    Content type: Study Protocol Published on:

  4. This study aimed to explore the clinical features and prognosis of cardiac metastatic tumors. In addition, whether continuing antitumor therapy after the development of cardiac metastases can benefit patients ...

    Authors: Zhongqiao Lin, Huazhen Xiao, Jun Liu, Ling Chen, Huishan Zhang, Yufang Huang, Yu Chen and Jing Lin
    Citation: BMC Cancer 2023 23:1235
    Content type: Research Published on:

  5. The Syrian decade-long war has severely affected the healthcare system, including almost vanishing cancer screening practices, war-destroyed medical facilities, and lack of continuous medical education. This s...

    Authors: Fouad Nahhat, Modar Doyya, Kareem Zabad, Tarek Abo Laban, Hasan Najjar, Maher Saifo and Firas Badin
    Citation: BMC Cancer 2023 23:1234
    Content type: Research Published on:

  6. Brain metastases (BM) are a common complication in advanced cancer patients, and extremely challenging to treat. Consequently, whole brain radiotherapy (WBRT) remains the standard palliative intervention for p...

    Authors: Bolanle Adegboyega, Adedayo Joseph, Adewumi Alabi, John Omomila, Lindokuhle M. Ngema, Victoria Ainsworth, Jennifer Chin, Moses O Evbuomwan and Wilfred Ngwa
    Citation: BMC Cancer 2023 23:1233
    Content type: Research Published on:

  7. Prehabilitation and recovery programmes aim to optimise patients’ physical fitness and mental well-being before, during and after cancer treatment. This paper aimed to understand the impact of such a programme...

    Authors: Rachael Powell, Amy Davies, Kirsty Rowlinson-Groves, David P. French, John Moore and Zoe Merchant
    Citation: BMC Cancer 2023 23:1232
    Content type: Research Published on:

  8. We created discriminative models of different regions of interest (ROIs) using radiomic texture features of neurite orientation dispersion and density imaging (NODDI) and evaluated the feasibility of each mode...

    Authors: Jie Bai, Mengyang He, Eryuan Gao, Guang Yang, Hongxi Yang, Jie Dong, Xiaoyue Ma, Yufei Gao, Huiting Zhang, Xu Yan, Yong Zhang, Jingliang Cheng and Guohua Zhao
    Citation: BMC Cancer 2023 23:1231
    Content type: Research Published on:

  9. This study aimed to investigate the differences in the clinicopathological characteristics of younger and older patients with endometrial cancer (EC) and develop a nomogram to assess the prognosis of early ons...

    Authors: Meng Zhang, Ruiping Li, Jiaxi Zhang, Yunyun Wang, Yunlu Wang and Yuzhen Guo
    Citation: BMC Cancer 2023 23:1230
    Content type: Research Published on:

  10. Pancreatic cancer (PC) is a malignant tumor with extremely poor prognosis, exhibiting resistance to chemotherapy and immunotherapy. Nowadays, it is ranked as the third leading cause of cancer-related mortality...

    Authors: XueAng Liu, Jian Shi, Lei Tian, Bin Xiao, Kai Zhang, Yan Zhu, YuFeng Zhang, KuiRong Jiang, Yi Zhu and Hao Yuan
    Citation: BMC Cancer 2023 23:1229
    Content type: Research Published on:

  11. Behind breast, colorectal, and lung cancers, cervical cancer is the fourth most common cancer affecting females. Despite, it is a preventable form of cancer both the incidence and mortality figures reflect it ...

    Authors: Amare Zewdie, Solomon Shitu, Natnael Kebede, Anteneh Gashaw, Habitu Birhan Eshetu, Tenagnework Eseyneh and Abebaw Wasie Kasahun
    Citation: BMC Cancer 2023 23:1228
    Content type: Research Published on:

  12. The association between chemotherapy-induced leukopenia (CIL) and survival for patients with early breast cancer (EBC) is not known. We investigated the relationship between different grades of CIL and surviva...

    Authors: Li Wang, Chang Jiang, Na Wang, Yan-Ling Wen, Si-Fen Wang, Cong Xue, Xi-Wen Bi and Zhong-Yu Yuan
    Citation: BMC Cancer 2023 23:1227
    Content type: Research Published on:

  13. This study aimed to evaluate the perioperative safety and efficacy of the Mini-open and trans-tubular approach in patients with spinal metastases who underwent decompression surgery.

    Authors: Yunpeng Cui, Chuan Mi, Bing Wang, Yuanxing Pan, Yunfei Lin and Xuedong Shi
    Citation: BMC Cancer 2023 23:1226
    Content type: Research Published on:

  14. The purpose of this study is to investigate the relationship between clinical characteristics and cervical lymph node metastasis (LNM) in patients with thyroid carcinoma, as well as estimate the preoperative d...

    Authors: Bei Wei, Jincao Yao, Chanjuan Peng, Shanshan Zhao, Hui Wang, Liping Wang, Xi Zhu, Yuting Kong, Liyu Chen and Dong Xu
    Citation: BMC Cancer 2023 23:1225
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2024 24:145

  15. The clinical relevance of circulating tumor cell-white blood cell (CTC-WBC) clusters in cancer prognosis is a subject of ongoing debate. This study aims to unravel their contentious predictive value for patien...

    Authors: Mingguang Ju, Ziming Gao, Gaoxiang Gu, Haibo Huang, Anqi Sun, Chen Zheng, He Li, Yixiao Zhang and Kai Li
    Citation: BMC Cancer 2023 23:1224
    Content type: Research Published on:

  17. Capture of cancer stage at diagnosis is important yet poorly reported by health services to population-based cancer registries. In this paper we describe current completeness of stage information for endometri...

    Authors: S. M. Evans, K. Ivanova, R. Rome, D. Cossio, CHC Pilgrim, J. Zalcberg, Y. Antill, L. Blake, A. Du Guesclin, A. Garrett, D. Giffard, N. Golobic, D. Moir, S. Parikh, A. Parisi, K. Sanday…
    Citation: BMC Cancer 2023 23:1222
    Content type: Research Published on:

  18. The combinations of PD-1 inhibitors with paclitaxel/cisplatinum (PD-1 + TP) and fluoropyrimidine/cisplatinum (PD-1 + FP) both have been shown to improve overall survival (OS) and progression-free survival (PFS...

    Authors: Jia Zhao, Simeng Zhang, Xiaoyu Guo, Ce li, Bowen Yang, Xiujuan Qu and Shuo Wang
    Citation: BMC Cancer 2023 23:1221
    Content type: Research Published on:

  19. The aim of this study is to evaluate an AAV vector that can selectively target breast cancer cells and to investigate its specificity and anti-tumor effects on breast cancer cells both in vitro and in vivo, of...

    Authors: Ya-feng Lv, Hao Zhang, Zhi Cui, Cui-jiao Ma, Yu-ling Li, Hua Lu, Hong-yan Wu, Jian-lin Yang, Chun-yu Cao, Wen-zheng Sun and Xiao-fei Huang
    Citation: BMC Cancer 2023 23:1220
    Content type: Research Published on:

  20. Breast Cancer (BC) is a formidable global health challenge, and Iran is no exception, with BC accounting for a significant proportion of women’s malignancies. To gain deeper insights into the epidemiological c...

    Authors: Mohsen Soleimani, Seyed Mohammad Ayyoubzadeh, Ahmad Jalilvand and Marjan Ghazisaeedi
    Citation: BMC Cancer 2023 23:1219
    Content type: Research Published on:

  21. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12885-023-11677-6.

    Authors: Shogo Amano, Seiji Kaino, Shuhei Shinoda, Hirofumi Harima, Toshihiko Matsumoto, Koichi Fujisawa, Taro Takami, Naoki Yamamoto, Takahiro Yamasaki and Isao Sakaida
    Citation: BMC Cancer 2023 23:1218
    Content type: Retraction Note Published on:

  22. Since Immune response, nutritional status and Epstein–Barr Virus (EBV) DNA status have been confirmed to be relevant to the prognosis of patients with nasopharyngeal carcinoma (NPC), we believe that the combin...

    Authors: Shuting Wu, Xiaofei Yuan, Haoran Huang, Yanfei Li, Linchong Cui, Danfan Lin, Wenxuan Lu, Huiru Feng, Zilu Chen, Xiong Liu, Jiajie Tan and Fan Wang
    Citation: BMC Cancer 2023 23:1217
    Content type: Research Published on:

  23. Women living with HIV are at increased risk of developing cervical cancer (CC). Screening for cancer is an important preventive strategy for the early detection of precancerous lesions and its management. Ther...

    Authors: Easwaran Vigneshwaran, Narayana Goruntla, Bhavana Reddy Bommireddy, Mohammad Jaffar Sadiq Mantargi, Bhavani Mopuri, Durga Prasad Thammisetty, Kasturi Vishwanathasetty Veerabhadrappa and Sarad Pawar Naik Bukke
    Citation: BMC Cancer 2023 23:1216
    Content type: Research Published on:

  24. The objective of this study was to estimate the accuracy of transcriptome-based classifier in differential diagnosis of uterine leiomyoma and leiomyosarcoma. We manually selected 114 normal uterine tissue and ...

    Authors: Kidong Kim, Sarah Kim, TaeJin Ahn, Hyojin Kim, So-Jin Shin, Chel Hun Choi, Sungmin Park, Yong-Beom Kim, Jae Hong No and Dong Hoon Suh
    Citation: BMC Cancer 2023 23:1215
    Content type: Research Published on:

  25. CD147, a transmembrane glycoprotein, has been implicated in various cancer-related processes but its role in breast cancer remains poorly understood. Herein, we investigated the expression of CD147 in differen...

    Authors: Fang Li, Jing Wang, Yu-qiong Yan, Chong-zhi Bai and Ji-qiang Guo
    Citation: BMC Cancer 2023 23:1214
    Content type: Research Published on:

  26. Breast cancer (BC) patients tend to suffer from distant metastasis, especially bone metastasis.

    Authors: Kang Yao, Zhu Xiaojun, Zhao Tingxiao, Liao Shiyao, Ji Lichen, Zhang Wei, Li Yanlei, Tian Jinlong, Ding Xiaoyan, Zhang Jun, Bi Qing and Lv Jun
    Citation: BMC Cancer 2023 23:1213
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2023 23:1265

  27. Anastomotic leakage (AL) is a severe complication following esophagectomy with high mortality. Perioperative decreased serum albumin level is considered a predictive of AL, however, its impact on AL incidence ...

    Authors: Ying-Jian Wang, Xian-Feng Xie, Yi-Qiu He, Tao Bao, Xian-Dong He, Kun-Kun Li and Wei Guo
    Citation: BMC Cancer 2023 23:1212
    Content type: Research Published on:

  28. Human papillomavirus (HPV) has been confirmed as a major causative factor for malignant transformation of cervical epithelial cells and for the development of cervical intraepithelial neoplasia (CIN) and invas...

    Authors: Linghua Kong, Xiaoping Xiao, Tao Xu, Ru Wan and Fei Chen
    Citation: BMC Cancer 2023 23:1211
    Content type: Research Published on:

  29. The main aim of this study was to establish the clinicopathological and prognostic correlations between endometriosis-associated and non-endometriosis-associated primary ovarian cancer, with a view to providin...

    Authors: Huimin Wang, Cong Chen, Danbo Wang, Yanmei Zhu and Peng Chen
    Citation: BMC Cancer 2023 23:1210
    Content type: Research Published on:

  30. Immune checkpoint inhibitors of programmed cell death protein 1 (PD-1) represent a significant breakthrough in treating head and neck squamous cell carcinoma (HNSCC), with long-lasting responses and prolonged ...

    Authors: Carinato Hélène, Ombline Conrad, Carole Pflumio, Christian Borel, Manon Voegelin, Alexandre Bernard, Philippe Schultz, Mihaela-Alina Onea, Alain Jung, Sophie Martin and Mickaël Burgy
    Citation: BMC Cancer 2023 23:1209
    Content type: Study Protocol Published on:

  31. Evaluating the effects of cancer diagnosis and treatment on a patient’s overall well-being is crucial and health-related quality of life (HRQoL) is a reliable metric for assessing this impact. Little is known ...

    Authors: Md. Shahjalal, Marufa Sultana, Jeff Gow, Mohammad Enamul Hoque, Sabuj Kanti Mistry, Ahmed Hossain and Rashidul Alam Mahumud
    Citation: BMC Cancer 2023 23:1208
    Content type: Research Published on:

  32. Myeloproliferative neoplasms (MPNs) are a group of haematological malignancies that affect approximately 8 people in every 100,000 individuals in the UK. Little is known about the aetiology of MPNs, as previou...

    Authors: Nouf Abutheraa, Emma-Louise Tarburn, Charlene M. McShane, Andrew Duncombe, Mary Frances McMullin and Lesley Ann Anderson
    Citation: BMC Cancer 2023 23:1207
    Content type: Study Protocol Published on:

  33. Lymphocyte-activation gene 3 (LAG3) is an immune checkpoint receptor; novel LAG3 immune checkpoint inhibitors (ICIs) exhibit therapeutic activity in melanoma. The role of LAG3and ICIs of LAG3 are unknown in ma...

    Authors: Ken Arimura, Kenzo Hiroshima, Yoji Nagashima, Tadao Nakazawa, Akira Ogihara, Mami Orimo, Yasuto Sato, Hideki Katsura, Masato Kanzaki, Mitsuko Kondo and Etsuko Tagaya
    Citation: BMC Cancer 2023 23:1206
    Content type: Research Published on:

  34. Gastrointestinal (GI) cancers (gastric cancer, oesophageal cancer, liver cancer, colorectal cancer, etc.) are the most common cancers with the highest morbidity and mortality in the world. The therapy for most...

    Authors: Jing Gao, Jianqiang Lan, Haiyan Liao, Fang Yang, Pei Qiu, Feng Jin, Shubin Wang, Lin Shen, Tengfei Chao, Cheng Zhang and Yu Zhu
    Citation: BMC Cancer 2023 23:1205
    Content type: Review Published on:

  35. Though our previous study has demonstrated that the single-incision plus one-port laparoscopic surgery (SILS + 1) is safe and feasible for sigmoid colon and upper rectal cancer and has better short-term outcom...

    Authors: Xuehua Zhang, Haitao Yuan, Zilin Tan, Gaohua Li, Zhenzhao Xu, Jinfan Zhou, Jie Fu, Mingyi Wu, Jiafei Xi and Yanan Wang
    Citation: BMC Cancer 2023 23:1204
    Content type: Research Published on:

  37. Surgical resection followed by indicated adjuvant therapy offers potential curative treatment in colonic adenocarcinoma. Beyond the well-established seed and soil theory of colon cancer progression, the 'norma...

    Authors: Tharathorn Suwatthanarak, Pariyada Tanjak, Thanawat Suwatthanarak, Onchira Acharayothin, Kullanist Thanormjit, Amphun Chaiboonchoe, Thikhamporn Tawantanakorn, Chainarong Phalanusitthepha, Atthaphorn Trakarnsanga, Asada Methasate, Manop Pithukpakorn, Ryuichi Okamoto and Vitoon Chinswangwatanakul
    Citation: BMC Cancer 2023 23:1202
    Content type: Research Published on:

  38. Recapitulating the tumor microenvironment (TME) in vitro remains a major hurdle in cancer research. In recent years, there have been significant strides in this area, particularly with the emergence of 3D sphe...

    Authors: Khushwant Singh and Pramod K. Gautam
    Citation: BMC Cancer 2023 23:1201
    Content type: Research Published on:

  39. The mammalian target of rapamycin (mTOR) kinase, a central component of the PI3K/AKT/mTOR pathway, plays a critical role in tumor biology as an attractive therapeutic target. We conducted this first-in-human s...

    Authors: Jiani Wang, Lin Gui, Yuxin Mu, Jiayu Wang, Yihebali Chi, Zhenteng Liu, Qing Li and Binghe Xu
    Citation: BMC Cancer 2023 23:1200
    Content type: Research Published on:

  40. Textbook outcome (TO) is a composite measure reflecting various aspects of services provided to patients with solid malignancies. We sought to evaluate the importance of various TO components previously propos...

    Authors: L Bobrzynski, K Sędłak, K Rawicz-Pruszyński, P Kolodziejczyk, A Szczepanik, W Polkowski, P Richter and M Sierzega
    Citation: BMC Cancer 2023 23:1199
    Content type: Research Published on:

  41. Due to the high drug resistance of hepatocellular carcinoma (HCC), sorafenib has limited efficacy in the treatment of advanced HCC. Cancer-associated fibroblasts (CAFs) play an important regulatory role in the...

    Authors: Jiali Zhao, En Lin, Zirui Bai, Yingbin Jia, Bo Wang, Yihua Dai, Wenfeng Zhuo, Guifang Zeng, Xialei Liu, Chaonong Cai, Peiping Li, Baojia Zou and Jian Li
    Citation: BMC Cancer 2023 23:1198
    Content type: Research Published on:

  42. A worldwide increased incidence of HM has been marked in recent decades. Therefore, to update epidemiological characteristics of HM in a French West Indies territory, we have performed analysis through Martini...

    Authors: Rémi Houpert, Thierry Almont, Rostom Belahreche, Mamadi Faro, Jennie Okouango, Mylène Vestris, Jonathan Macni, Olivier Pierre-Louis, Christelle Montabord, Murielle Beaubrun-Renard, Naby Soumah, Martial Boisseau, Jacqueline Véronique-Baudin and Clarisse Joachim
    Citation: BMC Cancer 2023 23:1197
    Content type: Research Published on:

  43. Immunotherapy in combination with platinum-etoposide (EP) chemotherapy has been approved as a first-line treatment for extensive-stage small cell lung cancer (ES-SCLC). However, real-world (RW) data regarding ...

    Authors: Yanrong Wang, Lingling Li, Jia Hu, Yan Zhao, Huan Yan, Ming Gao, Xuejiao Yang, Xia Zhang, Junxun Ma and Guanghai Dai
    Citation: BMC Cancer 2023 23:1196
    Content type: Research Published on:

  44. To detect circulating tumor cells (CTCs) in the peripheral blood of patients with tumor, and to analyze the significance of CTC detection in tumor diagnosis and monitoring. In the present study, peripheral blo...

    Authors: Yuanrui Liu, Rong Zhao, Zaichun Xie, Zhiyu Pang, Shengjie Chen, Qian Xu and Zhanfeng Zhang
    Citation: BMC Cancer 2023 23:1195
    Content type: Research Published on:

  45. Myxofibrosarcoma is a rare malignant soft tissue sarcoma characterised by multiple local recurrence and can become of higher grade with each recurrence. Consequently, myxofibrosarcoma represents a burden for p...

    Authors: Ania Naila Guerrieri, Chiara Bellotti, Marianna Penzo, Marta Columbaro, Micaela Pannella, Alessandro De Vita, Marco Gambarotti, Laura Mercatali, Roberta Laranga, Barbara Dozza, Silvia Vanni, Serena Corsini, Tommaso Frisoni, Giacomo Miserocchi, Toni Ibrahim and Enrico Lucarelli
    Citation: BMC Cancer 2023 23:1194
    Content type: Research Published on:

  46. Tumor-infiltrating lymphocytes (TILs) by routine hematoxylin and eosin staining (H&E-TILs) are a robust prognostic biomarker in various cancers. However, the role of H&E-TILs in esophageal squamous cell carcin...

    Authors: Jifang Zheng, Hejun Zhang, Siya Li, Zhaoxin Kang, Fei Zheng, Qiwei Yao, Xueqing Zhang, Ziyi Wu, Jiezhong Wang, Weimin Fang, Jiancheng Li, Gang Chen, Yuangui Chen and Mingqiu Chen
    Citation: BMC Cancer 2023 23:1193
    Content type: Research Published on:

  47. The current gastric cancer staging system relies on the number of metastatic lymph nodes (MLNs) for nodal stage determination. However, incorporating additional information such as topographic status may help ...

    Authors: Chul-Hyo Jeon, Ki Bum Park, Hayemin Lee, Dong Jin Kim, Ho Seok Seo, Junhyun Lee, Kyung Hwa Jun, Jin Jo Kim and Han Hong Lee
    Citation: BMC Cancer 2023 23:1192
    Content type: Research Published on:

  48. Patients diagnosed with low-risk prostate cancer (PCa) are confronted with a difficult decision regarding whether to undergo definitive treatment or to pursue an active surveillance protocol. This is potential...

    Authors: Alice Guan, Eduardo J. Santiago-Rodríguez, Benjamin I. Chung, Janet K. Shim, Laura Allen, Mei-Chin Kuo, Kathie Lau, Zinnia Loya, James D. Brooks, Iona Cheng, Mindy C. DeRouen, Dominick L. Frosch, Todd Golden, John T. Leppert, Daphne Y. Lichtensztajn, Qian Lu…
    Citation: BMC Cancer 2023 23:1191
    Content type: Research Published on:

  49. Routine clinical staging for hepatocellular carcinoma (HCC) incorporates liver function, general health, and tumor morphology. Further refinement of prognostic assessments and treatment decisions may benefit f...

    Authors: Kong-Ying Lin, Qing-Jing Chen, Shi-Chuan Tang, Zhi-Wen Lin, Jian-Xi Zhang, Si-Ming Zheng, Yun-Tong Li, Xian-Ming Wang, Qiang Lu, Jun Fu, Luo-Bin Guo, Li-Fang Zheng, Peng-Hui You, Meng-Meng Wu, Ke-Can Lin, Wei-Ping Zhou…
    Citation: BMC Cancer 2023 23:1190
    Content type: Research Published on:

  50. Chemoradiation therapy (CRT) followed by surgery is currently the standard of care to treat patients with locally advanced rectal cancer (LARC). CRT reduces local recurrences, but is associated with significan...

    Authors: D. M. Mens, J. M. van Rees, S. M. Wilting and C. Verhoef
    Citation: BMC Cancer 2023 23:1187
    Content type: Study Protocol Published on:

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